Radio frequency plasma adaptive resonance virtual electrode device

Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a radio frequency plasma adaptive resonance virtual electrode device. The device comprises a radio frequency power supply, a Tesla coil, a copper cylinder, a virtual electrode and a lower pole plate, the radio frequency power supply is connected to a primary coil of the Tesla coil through a coaxial transmission line and supplies power to the Tesla coil, the primary coil and a secondary coil of the Tesla coil generate magnetic coupling resonance, and the virtual electrode is arranged on the lower pole plate. The copper cylinder extending out of the secondary coil breaks down inert gas in the virtual electrode, and therefore a plasma area is formed. A Tesla coil is used for generating a strong electromagnetic field, inert gas in a virtual electrode is broken down to form a plasma area, and along with load change, the discharge area of radio frequency plasma automatically changes to compensate the capacitance value of the radio frequency plasma to LC resonance; the virtual electrode can adaptively change the discharge area in real time, the effect of adaptive impedance matching is achieved, and a radio frequency impedance matcher does not need to be used.

Description

Technical Field

[0001] The invention belongs to the technical field of medical equipment, and in particular relates to a radio frequency plasma adaptive resonance virtual electrode device. Background Art

[0002] Impedance matching device refers to a circuit that matches the output impedance and input impedance between two circuits. It can accurately adjust and optimize the matching relationship between the output impedance and input impedance of two connected circuits. Ideally, when the load impedance is equal to the characteristic impedance of the transmission line, the best transmission is achieved. This impedance state avoids energy reflection, ensures a smooth transition of the signal wavefront, and generates no reflected waves, so that all energy is fully absorbed and utilized by the load, significantly improving the efficiency of energy transmission.

[0003] The main treatments for cancer include chemotherapy, radiotherapy, and immunotherapy, but the above traditional treatments often cause certain toxic side effects to patients. While killing cancer cells, they will damage normal body cells, which will also cause certain harm to patients. Cancer cells are mutated human cells. Cancer cells are more susceptible to heat than normal cells. At a temperature of 42 degrees, cancer cells will be killed after a period of time, but the tolerance limit of normal tissue cells is around 45 degrees. Raising the temperature to 42 to 44 degrees can destroy tumor cells without damaging normal tissue cells. Non-invasive tumor cell apoptosis technology mainly induces programmed cell death of tumor cells through external means without directly invading the patient's body. This method can evenly heat tumor cells, and is less traumatic and recovers faster than traditional surgery.

[0004] Lu Hui used the changing law of the Smith chart in "Research and Implementation of RF Impedance Automatic Matching Method [D]. Zhengzhou University, 2017" to design an RF impedance automatic matcher, which mainly uses Rogowski coil, capacitor voltage divider, AD8302 amplitude-phase converter, STM32F103ZE processor and stepper motor to achieve the purpose of impedance automatic matching. However, its execution module is a stepper motor, which is bulky to execute and has a slow response speed, which is inconsistent with the high efficiency required by modern industry, and the matching time is as long as 3s, which is a long time.

[0005] Chakarvarti SK et al. introduced local, regional and whole-body hyperthermia methods in "Hyperthermia techniques for cancer treatment: A review [J]. Int. J. PharmTech Res, 2015, 8 (6): 292-299." Various types of external applicators have been designed to directly control the thermal dose instead of using elevated temperatures for treatment. Experimental research results have shown that hyperthermia is an ideal complementary treatment and strong sensitizer for radiotherapy and many cytotoxic drugs, and it has been proven to be one of the best cancer treatment options. However, the control of the thermal dose during hyperthermia therapy requires very precise control and is difficult to control.

[0006] Mi Yan et al. studied the effects of pulse width, electric field strength, repetition frequency within the pulse train, and the number of pulses within the pulse train on cell apoptosis and cell necrosis rates in "Experimental study on the killing effect of high-frequency nanosecond pulse trains on skin cancer cells [J]. High Voltage Technology, 2018, 44(02): 584-590." and analyzed the influence of each parameter on cell apoptosis and cell necrosis rates. However, the cell apoptosis rate is still relatively low, and further research is needed to obtain the relationship between each parameter and cell apoptosis and cell necrosis rates using a multi-parameter fitting method.

[0007] In "Numerical Simulation and Quality Research of Radio Frequency Thawing of Frozen Hairtail [D]. Jiangnan University, 2023. DOI: 10.27169 / d.cnki.gwqgu.2023.001788.", Jiang Hanting constructed an electromagnetic-thermal coupling model of the radio frequency thawing process of hairtail based on the finite element analysis method, and verified the accuracy of the numerical simulation results through experiments. The article further evaluated the effects of natural thawing, low-temperature thawing and radio frequency thawing on the thawing efficiency and quality of frozen hairtail, and analyzed the mechanism of the influence of radio frequency thawing on the quality characteristics of hairtail. However, it did not consider whether the impedance characteristics of the entire system change when different individuals are placed, thereby affecting the changes in the electromagnetic field in the two electrodes.

[0008] A Chinese patent document with publication number CN111840807A discloses a microwave radio frequency coordinated rotational irradiation tumor full-area thermal therapy device, which performs deep and shallow layered complementary thermal penetration on the human body to achieve full-area precise high fever and hot blanching for radical treatment of tumors. However, the device needs to cool down the fat areas at both ends during heating.

[0009] A Chinese patent document with publication number CN118415289A discloses a radio frequency thawing device and electrical equipment, which achieves the effect of quickly thawing frozen objects in the device. However, the impedance matching of the tuned inductor module in the device cannot keep up with the impedance change of the capacitive load, resulting in low radio frequency energy efficiency and failure to achieve the application purpose.

[0010] In summary, in the use of non-invasive tumor cell apoptosis technology and radiofrequency thawing technology, the traditional radiofrequency matching device has hysteresis, and the impedance matching cannot keep up with the impedance change of the load. Therefore, how to develop a device that can achieve real-time adaptive impedance matching is a problem that needs to be solved at present. Summary of the invention

[0011] The purpose of the present invention is to overcome the above-mentioned problems existing in the conventional technology and to provide a radio frequency plasma adaptive resonant virtual electrode device.

[0012] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0013] The invention provides a radio frequency plasma adaptive resonance virtual electrode device, comprising a radio frequency power supply, a primary coil, a secondary coil, a copper cylinder, a virtual electrode and a lower electrode plate; the primary coil and the secondary coil are combined to form a Tesla coil, the radio frequency power supply is connected to the primary coil of the Tesla coil through a coaxial transmission line, the primary coil and the secondary coil are respectively wound up and down on the same plastic tube, the extended end of the secondary coil is connected to the copper cylinder, the virtual electrode is placed 2 mm below the copper cylinder, and the lower electrode plate is grounded and placed below the virtual electrode; the primary coil can generate magnetic coupling resonance with the secondary coil, the copper cylinder connected to the secondary coil can break down the inert gas in the virtual electrode, so as to form a plasma region; the plasma region adaptively changes the compensation capacitance value as different media are placed to achieve a resonance state.

[0014] Furthermore, in the above-mentioned radio frequency plasma adaptive resonant virtual electrode device, the frequency of the radio frequency power supply is set to 13.56 MHz.

[0015] Furthermore, in the above-mentioned radio frequency plasma adaptive resonant virtual electrode device, the primary coil is formed by winding 5 turns of hollow copper wire, and the secondary coil is formed by winding 68 turns of enameled wire.

[0016] Furthermore, in the above-mentioned radio frequency plasma adaptive resonant virtual electrode device, the diameter of the copper cylinder is 25 mm and the thickness is 3 mm.

[0017] Furthermore, in the above-mentioned RF plasma adaptive resonant virtual electrode device, the virtual electrode is a quartz cup body with a diameter of 50 mm and a height of 40 mm, and the interior of the quartz cup body is provided with a cylindrical cavity with a height of 26 mm and an inner diameter of 26 mm, and the interior of the cylindrical cavity is filled with inert gas.

[0018] Furthermore, in the above-mentioned radio frequency plasma adaptive resonant virtual electrode device, the lower electrode plate is a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

[0019] Furthermore, the above-mentioned RF plasma adaptive resonant virtual electrode device also includes a water-cooled circulating radiator, the RF power supply is arranged on the outside of the device casing, the primary coil, the secondary coil, the copper cylinder connected to the secondary coil, the virtual electrode, the lower electrode plate and the water-cooled circulating radiator are arranged on the inside of the device casing, and the water-cooled circulating radiator is used to control the temperature of the internal environment of the device casing; the RF power supply and the device casing are placed in a normal temperature room.

[0020] Furthermore, in the above-mentioned radio frequency plasma adaptive resonance virtual electrode device, its use method includes the following steps:

[0021] S1. Connect the RF power source to the primary coil through a coaxial transmission line to power the Tesla coil.

[0022] S2. The primary coil and the secondary coil of the Tesla coil generate magnetic coupling resonance; the copper cylinder connected to the secondary coil breaks down the inert gas in the virtual electrode to form a plasma region and generate an electromagnetic field;

[0023] S3. Automatically change the discharge area of ​​RF plasma to compensate for the capacitance value to LC resonance, thereby achieving adaptive impedance matching.

[0024] The beneficial effects of the present invention are:

[0025] The RF plasma adaptive resonant virtual electrode device proposed in the present invention is reasonably designed. The frequency of the RF power supply is set to 13.56MHz. The RF wave is radiated to the Tesla coil through the connection circuit. The primary coil and the secondary coil of the Tesla coil generate magnetic coupling resonance. After the Tesla coil boosts the voltage, the copper cylinder connected to the secondary coil breaks down the inert gas in the virtual electrode to form a plasma area. When the capacitance of the capacitive load becomes smaller, the discharge area of ​​the RF plasma automatically increases and increases its equivalent capacitance, compensating its capacitance value to LC resonance; vice versa. The virtual electrode can adaptively change the discharge area in real time, achieving the effect of adaptive impedance matching, and there is no need to use a RF impedance matcher, realizing the construction of a principle prototype of a capacitive load application device with a simple structure, low cost and high efficiency.

[0026] Of course, any product implementing the present invention does not necessarily need to achieve all of the above advantages at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0028] Figure 1 A connection circuit diagram of the device of the present invention;

[0029] Figure 2 It is a structural schematic diagram of the device of the present invention;

[0030] Figure 3 The electric field distribution diagram for changing the distance between the upper and lower plates;

[0031] Figure 4 The electric field distribution diagram for changing the diameter of the upper electrode plate;

[0032] Figure 5 This is the experimental diagram for changing the distance between the plates;

[0033] Figure 6 This is the experimental diagram for changing the medium between two plates;

[0034] In the accompanying drawings, the reference numerals of the various components are as follows:

[0035] 1-RF power supply, 2-primary coil, 3-secondary coil, 4-copper cylinder, 5-dummy electrode, 6-lower electrode plate, 7-water-cooled circulating radiator. DETAILED DESCRIPTION

[0036] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] like Figure 1-Figure 6 As shown, this embodiment provides a radio frequency plasma adaptive resonant virtual electrode device, which includes a radio frequency power supply 1, a primary coil 2 of a Tesla coil, a secondary coil 3 of a Tesla coil, a copper cylinder 4 connected to the secondary coil, a virtual electrode 5, a lower electrode plate 6 and a water-cooled circulating radiator 7; the radio frequency power supply 1 is connected to the primary coil 2 of the Tesla coil through a coaxial transmission line, the primary coil 2 of the Tesla coil and the secondary coil 3 of the Tesla coil undergo magnetic coupling resonance, and the copper cylinder 4 connected to the secondary coil breaks down the inert gas in the virtual electrode 5 to form a plasma region and generate an electromagnetic field.

[0038] The Tesla coil consists of a primary coil 2 and a secondary coil 3, wherein the primary coil is wound with 5 turns of hollow copper wire, and the secondary coil is wound with 68 turns of enameled wire. The copper cylinder is connected to the secondary coil of the Tesla coil, and the diameter of the copper cylinder is 25 mm and the thickness is 3 mm. The virtual electrode is a quartz cup with a diameter of 50 mm and a height of 40 mm, wherein the inner height of the recessed cup is 26 mm and the inner diameter is 26 mm. Through the boost of the Tesla coil, the copper cylinder breaks through the inert gas in the virtual electrode to form a plasma region and generate an electromagnetic field. The object containing tumor cells is placed in the electromagnetic field generated between the upper and lower electrodes for heating, thereby achieving the effect of non-invasive tumor cell apoptosis.

[0039] In this embodiment, both the primary coil and the secondary coil of the Tesla coil have self-inductance, and there is mutual inductance between the coils. When the frequency is set to 13.56MHz, the hollow copper wire and the enameled wire can be equivalent to the coil inductance, thereby forming a resonant circuit. The electric field generated by the device designed in this example at an operating frequency of 13.56MHz has the best effect on non-invasive tumor cell apoptosis and efficient radio frequency thawing.

[0040] like Figure 2 As shown, for the two application directions of non-invasive tumor cell apoptosis and efficient radiofrequency thawing, the structure of the virtual electrode 5 needs to be changed based on different target objects.

[0041] like Figure 3 and Figure 4 As shown in the figure, the electric field distribution between the upper and lower plates is simulated when different objects are placed and the capacitance changes.

[0042] like Figure 5 and Figure 6 As shown, Figure 5 In order to change the experimental phenomenon of the distance between the upper and lower plates, the distance between the upper and lower plates is gradually increased, and the plasma discharge area in the virtual electrode is also gradually increased. Figure 6 This is an experimental phenomenon of putting in different media. When a copper plate is put in, the plasma discharge area in the cup becomes smaller; when an aqueous solution is put in, the discharge area becomes larger than when a copper plate is put in.

[0043] This embodiment also provides a method for using the above-mentioned RF plasma adaptive resonant virtual electrode device, the steps are as follows:

[0044] The radio frequency power source 1 is connected to the primary coil 2 of the Tesla coil through a coaxial transmission line, and the primary coil 2 of the Tesla coil generates magnetic coupling resonance with the secondary coil 3. The copper cylinder 4 connected to the secondary coil breaks through the inert gas in the virtual electrode 5 to form a plasma region and generate an electromagnetic field. The organism containing cancer cells in the body is placed on the lower electrode plate 6, and the water-cooled circulating radiator 7 is started at the same time.

[0045] Among them, the copper material used in the primary coil 3 of the Tesla coil has excellent conductivity, the copper coil has good flexibility, is easy to bend, safe, stable and reliable, and has higher transmission efficiency. The plasma discharge area in the virtual electrode 5 changes automatically, and the capacitance value is compensated to LC resonance. The virtual electrode can adaptively change the discharge area in real time, achieving the beneficial effect of adaptive impedance matching, and achieving the advantages of simple structure, low cost, and high efficiency. The water-cooled circulating radiator 7 can keep the coil temperature at a lower level, greatly alleviating the problem of the coil being unable to work for a long time due to heating.

[0046] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A radio frequency plasma adaptive resonant virtual electrode device, characterized in that: The invention comprises a radio frequency power source (1), a primary coil (2), a secondary coil (3), a copper cylinder (4), a virtual electrode (5) and a lower electrode plate (6); the primary coil (2) and the secondary coil (3) are combined to form a Tesla coil; the radio frequency power source (1) is connected to the primary coil (2) of the Tesla coil via a coaxial transmission line; the primary coil (2) and the secondary coil (3) are respectively wound up and down on the same plastic tube; the extended end of the secondary coil (3) is connected to the copper cylinder (4); the virtual electrode (5) is placed 2 mm below the copper cylinder (4); the lower electrode plate (6) is grounded and placed below the virtual electrode (5); the primary coil (2) can generate magnetic coupling resonance with the secondary coil (3); the copper cylinder (4) connected to the secondary coil (3) can break through the inert gas in the virtual electrode (5), thereby forming a plasma region; the plasma region adaptively changes the compensation capacitance value as different media are placed to achieve a resonance state.

2. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The frequency of the radio frequency power source (1) is set to 13.56 MHz.

3. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The primary coil (2) is wound with 5 turns of hollow copper wire, and the secondary coil (3) is wound with 68 turns of enameled wire.

4. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The copper cylinder (4) has a diameter of 25 mm and a thickness of 3 mm.

5. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The virtual electrode (5) is a quartz cup body with a diameter of 50 mm and a height of 40 mm. A cylindrical cavity with a height of 26 mm and an inner diameter of 26 mm is arranged inside the quartz cup body. The interior of the cylindrical cavity is filled with an inert gas.

6. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The lower electrode plate (6) is a copper plate with a diameter of 150 mm and a thickness of 0.5 mm.

7. The RF plasma adaptive resonant virtual electrode device according to claim 1, characterized in that: The device also includes a water-cooled circulating radiator (7); the radio frequency power source (1) is arranged outside the device housing; the primary coil (2), the secondary coil (3), the copper cylinder (4) connected to the secondary coil, the virtual electrode (5), the lower electrode plate (6) and the water-cooled circulating radiator (7) are arranged inside the device housing; the water-cooled circulating radiator (7) is used to control the temperature of the internal environment of the device housing; and the radio frequency power source (1) and the device housing are placed in a normal temperature room.

8. The radio frequency plasma adaptive resonance virtual electrode device according to any one of claims 1 to 7, characterized in that: The method of use includes the following steps: S1, connecting a radio frequency power source (1) to a primary coil (2) via a coaxial transmission line, thereby powering the Tesla coil; S2, the primary coil (2) of the Tesla coil and the secondary coil (3) generate magnetic coupling resonance; the copper cylinder (4) connected to the secondary coil breaks through the inert gas in the virtual electrode (5), forming a plasma region and generating an electromagnetic field; S3. Automatically change the discharge area of ​​RF plasma to compensate for the capacitance value to LC resonance, thereby achieving adaptive impedance matching.

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