Preparation method and application of novel microbubble type product for relieving asthenopia

Abstract

The invention discloses a preparation method and application of a novel microbubble type product for relieving asthenopia. The product is mainly prepared from the following components: a lycium ruthenicum extract, a bilberry extract, lutein ester, zeaxanthin, blueberry anthocyanin and the like. According to the composition, medicinal and edible raw materials are combined with new food raw materials, lutein ester and zeaxanthin are in a golden proportion, the five raw materials have a synergistic effect, and the effects of relieving asthenopia and improving eyesight of the product can be comprehensively improved. The product is in the form of a microbubble tablet product, can be directly taken orally and can also be drunk after being soaked in water, bubbles are generated in the mouth or an aqueous solution, and the interestingness of product taking is improved. In the preparation process, the acid is granulated and then tableted, so that the technical problems that a microbubble product has strict requirements on environmental temperature and humidity and is easy to stick in the process are solved. According to the invention, part of acid is added and then tableted, so that the product is longer in lasting time of microbubble feeling and better in taste when being chewed and eaten.

Description

Technical Field

[0001] The present invention relates to the technical field of products for alleviating visual fatigue, and in particular to a novel microbubble product for alleviating visual fatigue, a preparation method of the product, and application of the product in the field of alleviating visual fatigue. Background Art

[0003] Black wolfberry: Wild black wolfberry is distributed in high mountain sand forests. It is rare and precious. The aqueous solution is sky blue and natural in color. Black wolfberry is the wild plant with the highest content of proanthocyanidins found so far. The anthocyanins it contains are the most effective natural free radical scavenger. Black wolfberry has the effects of enhancing immunity, delaying aging, and improving eyesight. It has a good health care effect on pseudomyopia in adolescents, dizziness in middle-aged and elderly people, fundus hemorrhage, diabetic retinopathy, cataracts, visual fatigue, and dry eyes.

[0004] Bilberry: It is rich in anthocyanins, which can promote the production of rhodopsin in the eyes, stabilize the microvessels in the eyes, and enhance the circulation of microvessels. It is also a strong oxidant that can reduce the damage of free radicals to the eyes and help prevent or delay the occurrence of cataracts. Anthocyanins do not have electrons that can be paired, and can effectively remove different oxygen free radicals to increase the number of free radicals absorbed, thereby protecting cells from damage by peroxides and exerting their antioxidant activity.

[0005] Lutein esters: Lutein in nature basically exists in the form of esterification. Lutein is a key pigment that constitutes the macular area of ​​the human retina. It can filter harmful light, help the eyes resist oxidation, protect the lens and the retina of the fundus, and reduce the occurrence of cataracts, presbyopia, and visual fatigue. Since the human body cannot synthesize lutein on its own, it must be ingested from the outside. The mechanism of lutein protecting eye health includes: it can absorb blue-violet light, so that the retina of the eye can resist the damage of blue light and ultraviolet rays; it is an important antioxidant that can quench free radicals in multiple structures; it supplements macular pigments to prevent and treat macular degeneration.

[0006] Zeaxanthin: Zeaxanthin and lutein are the only two natural carotenoids in the retina. They are essential carotenoids for the lens and have high aggregation specificity for ocular tissues. They specifically concentrate zeaxanthin in the macular spot through high-affinity binding proteins and specialized transport and metabolism proteins. They carry out light-induced oxidative stress response through light absorption and localized high-efficiency antioxidant properties to protect the macula from damage. Therefore, they play a particularly important role in maintaining eye health and visual protection.

[0007] Blueberry anthocyanins: Blueberry is a fruit rich in anthocyanins. As a natural compound with multiple biological activities, blueberry anthocyanins have multiple health benefits. Its antioxidant, anti-inflammatory, blood sugar-lowering, cardiovascular health-promoting, and anti-cancer effects are of great significance to maintaining human health.

[0008] The main functional ingredients of the products for relieving visual fatigue disclosed in the prior art are lutein esters and zeaxanthin, and the functional ingredients are single and the effect is not obvious. In the present invention, five raw materials that are beneficial to relieving visual fatigue are combined, and a new type of microbubble product for relieving visual fatigue is developed by using raw materials and technologies that combine traditional and modern methods. Compared with traditional products for relieving visual fatigue, the present invention optimizes the functional raw materials and increases the fun of eating. Several functional ingredients work together to enhance the effect, and the effect is significant. Summary of the invention

[0009] In view of the shortcomings of the prior art, the purpose of the present invention is to provide a novel method for preparing a microbubble product for relieving visual fatigue and the application of the product in the field of relieving visual fatigue. The product is convenient and simple to eat, and has the effects of helping to improve vision, relieve visual fatigue, and relieve dry eyes.

[0010] The main formula of the present invention includes: raw materials are black wolfberry extract, bilberry extract, lutein ester, zeaxanthin, blueberry anthocyanin, and auxiliary materials are anhydrous citric acid, sodium bicarbonate, sorbitol, D-mannitol, magnesium stearate, flavor and the like.

[0011] The present invention creatively selects five raw materials, namely, black wolfberry extract, bilberry extract, lutein ester, zeaxanthin and blueberry anthocyanin. The five raw materials are matched and combined, and the ingredients complement each other, which can comprehensively enhance the efficacy of the composition in relieving visual fatigue and improving vision.

[0012] Preferably, the novel microbubble product for relieving visual fatigue comprises, by weight, 1-5 parts of black wolfberry extract, 1-5 parts of bilberry extract, 1-2 parts of lutein ester, 0.2-0.4 parts of zeaxanthin, and 0.5-1 parts of blueberry anthocyanins.

[0013] The mass proportions of the black wolfberry extract can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, etc.

[0014] The weight proportions of the bilberry extract may be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, etc.

[0015] The mass fraction of the lutein ester can be 1 part, 1.5 parts, 2 parts, etc.

[0016] The mass fraction of zeaxanthin can be 0.2 parts, 0.3 parts, 0.4 parts, etc.

[0017] The mass fraction of the blueberry anthocyanins can be 0.5 parts, 0.7 parts, 0.8 parts, 1 part, etc.

[0018] The dosage ratio of the lutein ester to zeaxanthin is a golden ratio of 5:1.

[0019] In addition, the present invention also provides a main technology, a preparation method of a novel microbubble product for relieving visual fatigue, comprising the following steps:

[0020] Preferably, the corn starch paste concentration is 10-15% and the mesh size is 1.0-1.2 mm.

[0021] (3) Tableting: Mix the sieved raw materials, sodium bicarbonate, whole acid granules, part of anhydrous citric acid, sorbitol, flavoring, and magnesium stearate, and put the mixed materials into a tablet press for tableting.

[0022] Preferably, the mixing time is 20-25 min and the tablet weight is 0.75-1.0 g / tablet.

[0023] In the present invention, part of the anhydrous citric acid is granulated and part of the anhydrous citric acid is added. Part of the anhydrous citric acid is made into acid granules with D-mannitol and corn starch paste, so as to solve the technical problems that micro-bubble products are easy to stick in the process due to the large amount of acid and strict requirements on environmental temperature and humidity. The added part of the anhydrous citric acid first reacts with the added sodium bicarbonate to generate bubbles, so that the bubble feeling of the product appears earlier and the taste is better. DETAILED DESCRIPTION

[0025] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0026] The present invention packages each piece of product independently to prevent the product from getting damp after opening and affecting the use effect. The outer packaging uses a portable metal packaging box. The portable metal packaging box can be recycled after use, and the pollution to the environment is relatively small. Its small size and large capacity further highlight the concept of "portability".

[0027] Example 1

[0028] A novel microbubble product for relieving visual fatigue, characterized in that it comprises, by weight, 1 part of black wolfberry extract, 1 part of bilberry extract, 1 part of lutein ester, 0.2 part of zeaxanthin, and 0.5 part of blueberry anthocyanin;

[0029] The preparation process is divided into three steps:

[0030] (1) Pretreatment of raw materials and auxiliary materials: Grind the five functional raw materials and pass them through an 80-mesh sieve for later use; pass sorbitol through a 30-mesh sieve for later use; grind anhydrous citric acid and pass it through an 80-mesh sieve for later use.

[0031] (2) Acid-making granules: Mix anhydrous citric acid and D-mannitol evenly and add 10% corn starch paste to make acid granules; dry the acid granules and sieve them through a 1.0 mm sieve for later use.

[0032] (3) Tableting: Mix the sieved raw materials, sodium bicarbonate, acid granules, part of the anhydrous citric acid, sorbitol and flavor for 20 minutes, add magnesium stearate and mix for 5 minutes, put the mixed materials into the tablet press for tableting, 0.8 g / tablet.

[0033] Example 2

[0034] A novel microbubble product for relieving visual fatigue, characterized in that it comprises, by mass, 5 parts of black wolfberry extract, 5 parts of bilberry extract, 2 parts of lutein ester, 0.4 parts of zeaxanthin, and 1 part of blueberry anthocyanin.

[0035] The preparation process is divided into three steps:

[0036] (1) Pretreatment of raw materials and auxiliary materials: Grind the five functional raw materials and pass them through an 80-mesh sieve for later use; pass sorbitol through a 30-mesh sieve for later use; grind anhydrous citric acid and pass it through an 80-mesh sieve for later use.

[0037] (2) Acid-making granules: Mix anhydrous citric acid and D-mannitol evenly and add 15% corn starch paste to make acid granules; dry the acid granules and sieve them through a 1.2 mm sieve for later use.

[0038] (3) Tablet compression: Mix the sieved raw materials, sodium bicarbonate, acid granules, part of the anhydrous citric acid, sorbitol, and flavor for 25 minutes, add magnesium stearate and mix for 5 minutes, put the mixed materials into the tablet press for tablet compression, 0.8 g / tablet.

[0039] Example 3

[0040] A novel microbubble product for relieving visual fatigue, characterized in that it comprises, by weight, 1 part of black wolfberry extract, 1 part of bilberry extract, 1 part of lutein ester, 0.2 part of zeaxanthin, and 0.5 part of blueberry anthocyanin;

[0041] The preparation process is divided into three steps:

[0042] (1) Pretreatment of raw materials and auxiliary materials: Grind the five functional raw materials and pass them through an 80-mesh sieve for later use; pass sorbitol through a 30-mesh sieve for later use; grind anhydrous citric acid and pass it through an 80-mesh sieve for later use.

[0043] (2) Acid-making granules: Mix anhydrous citric acid and D-mannitol evenly and add 10% corn starch paste to make acid granules; dry the acid granules and sieve them through a 1.0 mm sieve for later use.

[0044] (3) Tablet compression: Mix the sieved raw materials, sodium bicarbonate, acid granules, part of the anhydrous citric acid, sorbitol, and flavor for 20 minutes, add magnesium stearate and mix for 5 minutes, put the mixed materials into the tablet press for tablet compression, 1 g / tablet.

[0045] Example 4

[0046] A novel microbubble product for relieving visual fatigue, characterized in that it comprises, by mass, 5 parts of black wolfberry extract, 5 parts of bilberry extract, 2 parts of lutein ester, 0.4 parts of zeaxanthin, and 1 part of blueberry anthocyanin.

[0047] The preparation process is divided into three steps:

[0049] (1) Pretreatment of raw materials and auxiliary materials: Grind the five functional raw materials and pass them through an 80-mesh sieve for later use; pass sorbitol through a 30-mesh sieve for later use; grind anhydrous citric acid and pass it through an 80-mesh sieve for later use.

[0050] (2) Acid-making granules: Mix anhydrous citric acid and D-mannitol evenly and add 15% corn starch paste to make acid granules; dry the acid granules and sieve them through a 1.2 mm sieve for later use.

[0051] (3) Tablet compression: Mix the sieved raw materials, sodium bicarbonate, acid granules, part of the anhydrous citric acid, sorbitol, and flavor for 25 minutes, add magnesium stearate and mix for 5 minutes, put the mixed materials into the tablet press for tablet compression, 1 g / tablet.

[0052] Comparative Example 1

[0053] The black wolfberry extract and the blueberry extract were removed from the formula, and the auxiliary material sorbitol was used to replace the two removed raw materials. The finished product was prepared according to the preparation process in Example 1.

[0054] Comparative Example 2

[0055] The black wolfberry extract was replaced with the Cassia seed extract, and the finished product was prepared according to the preparation process in Example 1.

[0056] Application Examples

[0057] The products of Examples 1-4 and Comparative Examples 1-2 were subjected to application tests.

[0058] Test Case

[0059] The subjects were selected as subjects between the ages of 18 and 50, who used their eyes for a long time and had fatigued vision. Those with eye diseases were excluded, and the subjects had not taken products related to the tested functions in the past 3 months. The subjects were grouped according to the requirements of randomization and double-blindness. The eye symptoms and visual examination of the subjects were fully considered during the grouping, and the factors such as age and gender were considered to be reasonably grouped. The test was divided into 7 groups, with 10 people in each group. Groups 1-4 took the products of embodiments 1-4, and groups 5 were placebo blank groups taking inert auxiliary materials such as corn starch to be pressed into tablet products. Groups 6-7 were control groups, with 6 groups taking comparative example 1 products and 7 groups taking comparative example 2 products. The usage and dosage were both, taken 2 times a day, 2 tablets each time. The test was carried out for a total of 60 days. After the test, the improvement of eye discomfort and visual fatigue symptoms (symptoms such as eye fatigue and dry eyes) of each group of personnel was evaluated respectively.

[0060] The grading of eye discomfort and visual fatigue symptoms is as follows:

[0061] Occasional refers to 1-2 times / day; sometimes refers to 3-4 times / day; often refers to more than 5 times / day.

[0062] The product efficacy determination criteria are as follows:

[0063] Symptom improvement: If any symptom improves and other symptoms do not worsen, the symptom is considered to have improved;

[0064] Effective: Symptoms are improved and the difference in visual persistence is greater than or equal to 10%;

[0065] Invalid: In other cases, it is invalid.

[0066] The test results are shown in the following table.

[0068] Table 1 Eye Discomfort Situation

[0069] Table 2 Efficacy determination table

[0070] It can be seen from Table 1 and Table 2 that the novel microbubble product for relieving visual fatigue of the present invention has an excellent effect of relieving visual fatigue, and the effect is significantly better than that of the blank group and the control group.

Claims

1. A new type of microbubble product for relieving visual fatigue, characterized in that: It is made from black wolfberry extract, bilberry extract, lutein ester, zeaxanthin and blueberry anthocyanins as main raw materials.

2. A novel microbubble product for relieving visual fatigue according to claim 1, characterized in that: The main raw materials are 1-5 parts of black wolfberry extract, 1-5 parts of bilberry extract, 1-2 parts of lutein ester, 0.2-0.4 parts of zeaxanthin and 0.5-1 parts of blueberry anthocyanin.

3. A novel microbubble product for relieving visual fatigue according to claim 2, characterized in that: The usage ratio of the lutein ester to zeaxanthin is 5:

1.

4. A method for preparing a novel microbubble product for relieving visual fatigue according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: (1) Raw material pretreatment: crush the raw materials, pass them through an 80-mesh sieve, weigh them and set them aside; (2) Acid-making granules: anhydrous citric acid and D-mannitol are mixed evenly and then added to corn starch paste to form acid granules; the acid granules are dried; and granulated using a sieve; (3) Tableting: Mix the sieved raw materials, sodium bicarbonate, whole acid granules, part of anhydrous citric acid, sorbitol, flavoring, and magnesium stearate, and put the mixed materials into a tablet press for tableting.

5. The method for preparing a novel microbubble product for relieving visual fatigue according to claim 4, characterized in that: The mesh size of the sieve described in step (2) is 1.0-1.2 mm.

6. The method for preparing a novel microbubble product for relieving visual fatigue according to claim 4, characterized in that: The concentration of the corn starch paste in step (2) is 10-15%.

7. The method for preparing a novel microbubble product for relieving visual fatigue according to claim 4, characterized in that: The mixing time for uniform mixing in step (3) is 20-25 minutes.

8. The method for preparing a novel microbubble product for relieving visual fatigue according to claim 4, characterized in that: Tablet weight is 0.75-1.0g / tablet.

9. The use of a novel microbubble product for relieving visual fatigue according to claim 4, characterized in that: The microbubble product for relieving visual fatigue is used for relieving visual fatigue and improving vision.

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