Drug target protein MoFrd1 and application thereof in agricultural disease control

By discovering the rice blast bacteria MoFrd1 as a new drug target and developing corresponding inhibitors or interfering substances, the problems of limited number of existing fungicide targets and high risk of drug resistance are solved, and effective prevention and treatment of rice blast and wheat gibberelliae are achieved.

CN119661667AActive Publication Date: 2025-03-21SANYA INSTITUTE OF NANJING AGRICULTURAL UNIVERSITY
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Patent Information

Application Number
CN202510191587.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-21
Publication Date
2025-03-21
Estimated Expiration
2045-02-21

AI Technical Summary

Technical Problem

The number of existing fungicide targets is limited, resulting in serious structural homogeneity and high drug resistance risk, making it difficult to effectively prevent and control crop diseases such as rice blast and wheat gibberellia.

Method used

The blast bacteria MoFrd1 was discovered and used as a new drug target, and the inhibitors that can inhibit their function were screened or designed through high-throughput screening technology, or the genes they encoded were used for gene editing or silencing, and a green bactericide with original structure and mechanism of action was developed.

Benefits of technology

It significantly improves the prevention and treatment effect of rice blast and wheat gibberellia, reduces the risk of pathogenic bacteria resistance, and provides innovative solutions for agricultural disease prevention and control.

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Abstract

The invention provides a drug target protein MoFrd1 and application of the drug target protein MoFrd1 in agricultural disease control. The amino acid sequence of the MoFrd1 is as shown in SEQ ID No. 1, and the nucleotide sequence of the coding gene of the MoFrd1 is as shown in SEQ ID No. 4. Researches show that the pathogenicity of the magnaporthe oryzae can be remarkably reduced by knocking out the MoFrd1 coding gene. Homologous protein of MoFrd1 widely exists in plant pathogenic fungi and shows high conservative property in pathogenic mechanisms, however, homologous protein is not found in plants and mammals, and it is indicated that the homologous protein of MoFrd1 has the potential of serving as a specific drug target of pathogenic bacteria. Based on a key structural domain and a functional site of the MoFrd1 protein, a specific agent for preventing and treating plant fungal pathogens is expected to be developed through design or screening. The invention provides a new drug target and a control strategy for controlling fungal diseases of crops, and has important application value and market potential.
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