An activatable semiconductor polymer, its preparation method and application
By designing activatable semiconductor polymers, the stability and sensitivity issues of existing materials in tracking immune cell migration and ICD immunotherapy have been resolved, enabling precise imaging and treatment of tumor sites and improving treatment outcomes.
CN119661858BActive Publication Date: 2026-05-26TAN KAH KEE INNOVATION LAB +1
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- TAN KAH KEE INNOVATION LAB
- Filing Date
- 2024-12-11
- Publication Date
- 2026-05-26
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Figure CN119661858B_ABST
Abstract
This invention provides an activatable semiconductor polymer, its preparation method, and its applications. The activatable semiconductor polymer of this invention can efficiently accumulate at tumor sites. Due to the presence of electron-withdrawing groups on its side chains, the polymer's fluorescence is quenched. Upon response to tumor markers—biothiols, reactive oxygen species, and cathepsin B—the polymer's fluorescence recovers, enabling precise imaging and sonodynamic therapy at the tumor site. Simultaneously, the activatable semiconductor polymer of this invention can label immune cells (such as dendritic cells and macrophages) and track their metastasis from the tumor to the draining lymph nodes.
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