A dynamic adjustment method and system for a Chinese herbal medicine extraction device

Abstract

The present invention relates to the technical field of Chinese medicine extraction, specifically to a dynamic adjustment method and system for a Chinese medicine extraction device, comprising the following steps: obtaining parameters in the Chinese medicine extraction device during the extraction process of medicinal materials, dividing the parameters according to fixed moments, calculating the entropy value of the corresponding parameters at each moment, evaluating the solvent flow rate adjustment space according to the entropy value change trend, and generating a solvent flow rate dynamic adjustment evaluation result. In the present invention, by dynamically adjusting multiple key operating parameters in the Chinese medicine extraction process, such as solvent flow rate, extraction time, temperature, etc., the accuracy and flexibility of the extraction process are significantly improved. In each step, the system obtains data through a real-time feedback mechanism and predicts future adjustment needs based on the entropy value change trend. This adjustment method based on real-time data avoids extraction under traditional fixed conditions. By real-time monitoring of the concentration of active ingredients, over-extraction or under-extraction is avoided, thereby maximizing the concentration of active ingredients.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine extraction, and in particular to a dynamic adjustment method and system for a traditional Chinese medicine extraction device. Background Art

[0002] The field of Chinese medicine extraction technology includes the research and application of the extraction, separation, and concentration of the effective components of Chinese medicinal materials. The core content of this field mainly involves how to extract the effective components from Chinese medicinal materials through physical, chemical, mechanical and other methods, using solvents, temperature, pressure and other conditions, in order to achieve the purpose of preparing Chinese medicine extracts, extracts and concentrates.

[0003] Among them, the dynamic adjustment method of the Chinese herbal medicine extraction device refers to dynamically adjusting multiple parameters in the extraction process to ensure that each link in the extraction process can reach the optimal state. It involves how to monitor and adjust key factors such as temperature, pressure, flow rate, solvent concentration, etc. in the extraction equipment in real time to optimize the Chinese herbal medicine extraction process. This method specifically uses a real-time feedback mechanism to dynamically adjust key operating parameters in the extraction process to avoid extraction under fixed conditions, thereby ensuring the efficiency and stability of the extraction process.

[0004] The disadvantage of the prior art is that its operating parameters usually rely on fixed preset conditions for extraction, and lack a mechanism for dynamically adjusting parameters based on real-time feedback. This fixed mode of operation may cause fluctuations in the extraction efficiency of the active ingredients, especially in terms of solvent flow rate, extraction time, solvent concentration, etc., and fails to fully consider the real-time needs of each extraction stage. Specifically, in traditional extraction devices, the concentration changes of active ingredients are usually not monitored in real time, and fixed settings of equipment parameters such as flow rate, temperature, extraction time, etc. may lead to excessive or insufficient extraction. For example, if the solvent flow rate is too low, the extraction efficiency of the active ingredients is low, and if the solvent flow rate is too high, it may lead to the loss of active ingredients. Traditional methods cannot dynamically optimize these parameters according to changes in the concentration of active ingredients, which can easily cause waste of medicinal materials or poor extraction effects. Therefore, the fixed operating mode cannot be flexible in dealing with complex and changing extraction requirements, resulting in the inability to maximize the efficiency of the extraction process, especially when dealing with different Chinese medicinal materials, lacking sufficient adaptability, and ultimately affecting the overall extraction effect of the active ingredients. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a dynamic adjustment method and system for a Chinese medicinal material extraction device.

[0006] In order to achieve the above object, the present invention adopts the following technical solution: a dynamic adjustment method of a Chinese medicinal material extraction device, comprising the following steps:

[0007] S1: Obtain the parameters of the Chinese herbal medicine extraction device during the extraction process, divide the parameters according to fixed time, calculate the entropy value of the corresponding parameters at each time, evaluate the solvent flow rate adjustment space according to the entropy value change trend, and generate the solvent flow rate dynamic adjustment evaluation result;

[0008] S2: Analyzing the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, automatically limiting the amplitude and frequency of the flow rate adjustment in the Chinese medicinal material extraction device with reference to the optimal solvent flow rate range, and obtaining the solvent flow rate optimization adjustment result;

[0009] S3: Real-time monitoring of the concentration changes of the Chinese medicinal material components in the solvent flow rate optimization adjustment result, defining the extraction objective function of each Chinese medicinal material, calculating the value of the objective function, and comparing the value of the objective function with the preset concentration of the active ingredient, dynamically adjusting the extraction time of the Chinese medicinal material extraction device according to the comparison result, and generating the Chinese medicinal material extraction time optimization result;

[0010] S4: Analyze the optimization adjustment results of the solvent flow rate and the optimization results of the Chinese medicinal material extraction time, the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredients, predict the future adjustment needs of the active ingredients, adjust the corresponding parameters in the medicinal material extraction process according to the future adjustment needs, and obtain the dynamic adjustment results of the Chinese medicinal material extraction device.

[0011] As a further solution of the present invention, the steps for obtaining the evaluation result of the dynamic adjustment of the solvent flow rate are specifically as follows:

[0012] S111: Obtaining the solvent flow rate, solvent concentration, and solvent temperature parameters during the medicinal material extraction process of the Chinese medicinal material extraction device, dividing the parameters during the medicinal material extraction process according to fixed time points, and obtaining a medicinal material extraction data division result;

[0013] S112: Based on the result of the division of the medicinal material extraction data, the formula is used:

[0014] ;

[0015] Calculate the entropy value of the corresponding parameter at each time t ;

[0016] in, represents the probability distribution of the i-th parameter at time t, represents the change of the i-th parameter between the previous and next moments, Represents the adjustment coefficient, and n represents the number of parameters involved in the calculation.

[0017] S113: By comparing the entropy value change trend of the corresponding parameter at each moment, the solvent flow rate adjustment space is evaluated according to the entropy value change trend, and the solvent flow rate dynamic adjustment evaluation result is generated.

[0018] As a further solution of the present invention, the step of obtaining the solvent flow rate optimization adjustment result is specifically:

[0019] S211: analyzing the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, automatically limiting the amplitude and frequency of the flow rate adjustment in the Chinese medicinal material extraction device with reference to the optimal solvent flow rate range, and obtaining the amplitude and frequency of the flow rate adjustment after limitation;

[0020] S212: Compare the amplitude and frequency of the flow rate adjustment after limitation with the instantaneous flow rate and the preset flow rate threshold range to determine whether the current flow rate is within the flow rate threshold range; if the instantaneous flow rate exceeds the flow rate threshold range, automatically perform iterative adjustment of the amplitude and frequency to obtain the solvent flow rate optimization adjustment result.

[0021] As a further solution of the present invention, the step of calculating the value of the objective function is specifically:

[0022] S311: real-time monitoring of the concentration changes of the Chinese medicinal materials in the solvent flow rate optimization adjustment result, defining the extraction objective function of each Chinese medicinal material according to the concentration changes of the Chinese medicinal materials, quantifying the extraction effect according to the objective function, and obtaining the quantified extraction effect;

[0023] S312: Based on the quantified extraction effect, the formula is used:

[0024] ;

[0025] Calculate the objective function value F;

[0026] in, represents the weight coefficient of the jth component, represents the concentration of the jth component at time t, represents the target concentration of the jth component, and m represents the number of active ingredients involved in the calculation.

[0027] As a further solution of the present invention, the steps for obtaining the optimization result of the extraction time of Chinese medicinal materials are specifically as follows:

[0028] S321: Compare the objective function value with the preset concentration of the active ingredient, and dynamically adjust the extraction time of the Chinese medicinal material extraction device according to the comparison result. If the concentration change of the active ingredient exceeds the preset change threshold, the extraction time is extended; if the concentration change of the active ingredient is lower than the preset change threshold, the extraction time is shortened to obtain the adjusted extraction effect;

[0029] S322: According to the adjusted extraction effect, check the degree of extension or shortening of the extraction time of the Chinese medicinal materials, and adjust it according to the current situation. If the extraction time needs to be extended, it is necessary to extend the extraction time according to the set ratio or time range. If the extraction time needs to be shortened, reduce the extraction time to obtain the optimization result of the extraction time of the Chinese medicinal materials.

[0030] As a further embodiment of the present invention, the step of predicting the future adjustment requirements of the active ingredient is specifically as follows:

[0031] S411: Based on the solvent flow rate optimization adjustment result and the Chinese medicinal material extraction time optimization result, compare the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredient, and determine whether it exceeds the preset active ingredient concentration change threshold, and generate the solvent flow rate and extraction time adjustment effect evaluation result;

[0032] S412: Based on the evaluation results of the solvent flow rate and extraction time adjustment effect, the formula is used:

[0033] ;

[0034] Calculate the concentration of active ingredients at a future time based on the current concentration change and time interval , according to the concentration of the active ingredient at a future time Analyze the change trend and obtain the analysis results of the future change trend of drug efficacy;

[0035] in, represents the concentration of the active ingredient at the current time t, It indicates the rate at which the concentration of the active ingredient changes with time. It represents the prediction time interval, which refers to the time difference from the current time t to the future time.

[0036] As a further solution of the present invention, the steps of dynamically adjusting the result of the Chinese medicinal material extraction device are specifically as follows:

[0037] S421: Based on the analysis result of the future change trend of the efficacy, analyzing the influence of the adjusted solvent flow rate and extraction time on the concentration of the active ingredient, and judging whether it is necessary to continue to adjust the extraction time or flow rate according to the change trend of the concentration, and generating an evaluation result of the change trend of the active ingredient concentration;

[0038] S422: Based on the evaluation result of the concentration change trend of the active ingredient, the corresponding parameters in the medicinal material extraction process are adjusted to obtain the dynamic adjustment result of the Chinese medicinal material extraction device.

[0039] A dynamic adjustment system for a Chinese medicinal material extraction device, the dynamic adjustment system for a Chinese medicinal material extraction device is used to execute the dynamic adjustment method for the Chinese medicinal material extraction device, the system comprising:

[0040] The solvent flow rate adjustment module obtains parameter data during the extraction process of Chinese medicinal materials, divides it into fixed moments, calculates the entropy value of the parameters at each moment, analyzes the entropy value change trend, evaluates the solvent flow rate adjustment space, and generates the solvent flow rate dynamic adjustment evaluation results;

[0041] The optimal flow rate range determination module determines the optimal solvent flow rate range by analyzing the solvent flow rate dynamic adjustment evaluation result, limits the flow rate adjustment amplitude and frequency, and generates the solvent flow rate optimization adjustment result;

[0042] The extraction time adjustment module monitors the concentration changes of the components in the solvent flow rate optimization adjustment result in real time, calculates the objective function and compares it with the preset concentration of the active ingredient, and dynamically adjusts the extraction time according to the comparison result to generate the optimization result of the extraction time of the Chinese herbal medicine;

[0043] The overall optimization and adjustment module analyzes the solvent flow rate optimization adjustment results and the Chinese medicinal material extraction time optimization results, evaluates the impact of the adjustment of the flow rate and extraction time on the concentration of the active ingredients, predicts future adjustment needs, adjusts the parameters during the extraction process, and generates dynamic adjustment results of the Chinese medicinal material extraction device.

[0044] Compared with the prior art, the advantages and positive effects of the present invention are:

[0045] In the present invention, by dynamically adjusting multiple key operating parameters in the extraction process of Chinese herbal medicine, such as solvent flow rate, extraction time, temperature, etc., the accuracy and flexibility of the extraction process are significantly improved. In each step, the system obtains data through a real-time feedback mechanism and predicts future adjustment needs based on the trend of entropy value changes. This adjustment method based on real-time data avoids the extraction under traditional fixed conditions and ensures the efficiency and stability of the extraction process. Through real-time monitoring of the concentration of active ingredients, the system can dynamically optimize the extraction time, avoid over-extraction or under-extraction, thereby maximizing the concentration of active ingredients. Through the maximum entropy principle analysis and comparison of the flow rate adjustment space, the system can automatically adjust the solvent flow rate to keep it within the optimal range, thereby improving the contact efficiency between the solvent and the medicinal material. The dynamic adjustment process is not only responsive, but also can adjust parameters according to the feedback results of each stage to ensure the stability of the entire extraction process under a changing environment. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 It is a schematic diagram of the workflow of the present invention;

[0047] Figure 2 A flow chart for obtaining evaluation results of dynamic adjustment of solvent flow rate according to the present invention;

[0048] Figure 3 A flow chart for obtaining the solvent flow rate optimization adjustment result of the present invention;

[0049] Figure 4 A flow chart for calculating the value of the objective function for the present invention;

[0050] Figure 5 A flow chart of the present invention for obtaining the optimization result of the extraction time of Chinese medicinal materials;

[0051] Figure 6 A flow chart for predicting future adjustment requirements of the active ingredient for the present invention;

[0052] Figure 7 The present invention is a flow chart for obtaining dynamic adjustment results of the Chinese medicinal material extraction device. DETAILED DESCRIPTION

[0053] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0054] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, in the description of the present invention, "multiple" means two or more, unless otherwise clearly and specifically defined.

[0055] See also Figure 1 The present invention provides a technical solution: a dynamic adjustment method of a Chinese medicinal material extraction device, comprising the following steps:

[0056] S1: Obtain the parameters of the Chinese herbal medicine extraction device during the extraction process, divide the parameters according to fixed time, calculate the entropy value of the corresponding parameters at each time, evaluate the solvent flow rate adjustment space according to the entropy value change trend, and generate the solvent flow rate dynamic adjustment evaluation result;

[0057] S2: Analyze the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, and automatically limit the amplitude and frequency of the flow rate adjustment in the Chinese herbal medicine extraction device with reference to the optimal solvent flow rate range, so as to obtain the solvent flow rate optimization adjustment result;

[0058] S3: Real-time monitoring of the concentration changes of Chinese medicinal materials components in the solvent flow rate optimization adjustment results, defining the extraction objective function of each Chinese medicinal material, calculating the value of the objective function, and comparing the value of the objective function with the preset concentration of the active ingredient, dynamically adjusting the extraction time of the Chinese medicinal material extraction device according to the comparison result, and generating the Chinese medicinal material extraction time optimization result;

[0059] S4: Analyze the optimization adjustment results of the solvent flow rate and the Chinese medicinal material extraction time, the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredient, predict the future adjustment needs of the active ingredient, adjust the corresponding parameters in the medicinal material extraction process according to the future adjustment needs, and obtain the dynamic adjustment results of the Chinese medicinal material extraction device;

[0060] The evaluation results of the dynamic adjustment of the solvent flow rate include the entropy value change trend and the solvent flow rate adjustment space;

[0061] The results of solvent flow rate optimization and adjustment include the optimal solvent flow rate range, flow rate adjustment amplitude and frequency, instantly obtained flow rate, flow rate threshold range, and iterative adjustment results; the results of Chinese medicinal material extraction time optimization include changes in active ingredient concentrations, extraction time adjustment, active ingredient concentration comparison, and objective function value; the results of dynamic adjustment of the Chinese medicinal material extraction device include flow rate adjustment, active ingredient change trend, future adjustment needs, and medicinal material extraction parameter adjustment.

[0062] See also Figure 2 , the specific steps for obtaining the evaluation results of the dynamic adjustment of the solvent flow rate are as follows:

[0063] S111: Obtaining the solvent flow rate, solvent concentration, and solvent temperature parameters during the medicinal material extraction process of the Chinese medicinal material extraction device, dividing the parameters during the medicinal material extraction process according to fixed time points, and obtaining a medicinal material extraction data division result;

[0064] First, set the time sampling interval and ensure that the operating status of the equipment can be accurately recorded at each time point. Data such as solvent flow rate, solvent concentration and solvent temperature can be collected in real time through sensors, and the PLC control system can be used to upload the data to the data storage platform at regular intervals, with the storage time point being the key moment. At each sampling moment, the current solvent flow rate, solvent concentration and solvent temperature values ​​are collected and recorded through the data collector. Through time series division, the collected solvent parameters are matched with their corresponding time tags, and the parameters at each fixed moment can be saved in the database.

[0065] S112: Based on the results of the medicinal material extraction data, the formula is:

[0066] ;

[0067] Calculate the entropy value of the corresponding parameter at each time t ;

[0068] in, It represents the probability distribution of the i-th parameter at time t, which is usually calculated by the normalized solvent flow rate, concentration or temperature parameter value. For example, if the solvent flow rate collected at a certain time is S, the concentration is C, and the temperature is T, the probability of each parameter is It can be calculated by the following formula: , is the value of the ith parameter, is the sum of all parameters, j is the index of all parameters, and n represents the number of parameters involved in the calculation, such as solvent flow rate, solvent concentration, solvent temperature, etc., usually 3. In this formula, n can be changed according to actual conditions. It represents the change of the i-th parameter between the previous and next moments, usually by calculating the difference between the current moment t and the previous moment The parameter difference is obtained by Represents the adjustment coefficient, which is used to weight the flexibility of parameter changes. In the formula, Adjust the weight of the parameter change in the entropy value, and determine the reasonable value through experiments or historical data analysis. For example, in some cases, the change of entropy value may be too sensitive. The calculation results can be stabilized by adjustment. If the solvent flow rate, concentration, temperature and other parameters change greatly at a certain moment (i.e. larger), then The value of should be large to increase the effect of the change on the entropy calculation. If the system parameter changes are relatively small (i.e. smaller), then The value of should be small to reduce the impact of the change on the entropy calculation. When it is larger, it means that the parameter change contributes more to the entropy value, thereby increasing the calculation result of the entropy value, making the system more sensitive to parameter fluctuations. This setting is usually suitable for scenarios that need to capture the law of parameter changes more accurately, and can better reflect the uncertainty and dynamic changes of the system. When it is smaller, the contribution of parameter change to entropy value is smaller, and the calculation result of entropy value will be more stable, reducing the calculation error caused by small fluctuations. When the system is stable, it is appropriate to reduce The value can avoid over-reaction to small parameter changes and ensure the smooth operation of the system.

[0069] At each time t, the parameters such as solvent flow rate, concentration and temperature are normalized to obtain the probability distribution of each parameter , and then substitute it into the improved entropy value calculation formula:

[0070] ;

[0071] For example, suppose that at time t, the solvent flow rate parameter , solvent concentration parameters Solvent temperature parameters , and the change before and after is , , , and set the adjustment coefficient , then the entropy value is calculated as:

[0072] ;

[0073] The result shows that at time t, the uncertainty of parameters such as solvent flow rate, concentration, and temperature is 1.1564.

[0074] S113: by comparing the entropy value change trend of the corresponding parameter at each moment, evaluating the solvent flow rate adjustment space according to the entropy value change trend, and generating a solvent flow rate dynamic adjustment evaluation result;

[0075] First, according to the entropy value corresponding to time t , and compare between multiple moments. For example, suppose at two consecutive moments and The corresponding entropy values ​​are and On this basis, the need for solvent flow rate adjustment can be evaluated based on the change trend of the entropy value. Specifically, the change in entropy value is first calculated. If the entropy value changes greatly, it means that the uncertainty of parameters such as solvent flow rate, concentration, and temperature has increased, and adjustments need to be made in the next operation to reduce volatility and system instability. If the entropy value changes slightly, it means that the parameters are relatively stable and the adjustment space is relatively small. In order to evaluate the adjustment space, a preset entropy value change threshold range can be set. For example, when When it is greater than 0.1, it means that a larger flow rate adjustment is required; when When it is less than 0.05, it means that the current solvent flow rate can be maintained; when When it is between 0.05 and 0.1, it means that the flow rate adjustment range is small. , it can be judged that the adjustment space of the solvent flow rate is large, and it is recommended to make a more significant adjustment. By comparing the entropy value change trend between different time nodes multiple times, the adjustment space of the solvent flow rate is gradually evaluated, and the final evaluation result of the dynamic adjustment of the solvent flow rate is generated. This evaluation result will provide a decision-making basis for the adjustment of the solvent flow rate according to the fluctuation range of the entropy value, ensuring that the adjustment of the solvent flow rate during the entire extraction process can effectively control the volatility and ensure the stability of the extraction effect.

[0076] See also Figure 3 , the specific steps for obtaining the solvent flow rate optimization adjustment results are:

[0077] S211: analyzing the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, automatically limiting the amplitude and frequency of the flow rate adjustment in the Chinese medicinal material extraction device with reference to the optimal solvent flow rate range, and obtaining the amplitude and frequency of the flow rate adjustment after limitation;

[0078] First, it is necessary to determine a maximum entropy range based on the entropy analysis results, which represents the optimal flow rate adjustment interval of the system. Entropy is an indicator of system uncertainty. The larger the entropy value, the more uncertain the changes in parameters such as solvent flow rate, concentration, and temperature, and the system needs a larger adjustment to reduce volatility; the smaller the entropy value, the more stable the parameter changes and the smaller the flow rate adjustment needs. Specifically, the range of entropy can be obtained through actual monitoring data. In general, an entropy value less than 0.5 indicates that the system is very stable, the parameters change less, the flow rate adjustment amplitude should be small, and the frequency can be appropriately increased; when the entropy value is between 0.5 and 1.0, it means that the system has a certain degree of uncertainty and needs to adjust the flow rate appropriately, and the frequency and amplitude are subject to certain restrictions; when the entropy value is greater than 1.0, it means that the uncertainty of the system is high, the flow rate adjustment amplitude needs to be large, and the frequency is low to avoid frequent fluctuations and adjustments. By analyzing the change trend of the entropy value, the optimal solvent flow rate adjustment range can be further determined to ensure that the flow rate adjustment can both meet the extraction effect and avoid system instability.

[0079] S212: comparing the amplitude and frequency of the flow rate adjustment after limitation with the flow rate obtained in real time and the preset flow rate threshold range to determine whether the current flow rate is within the flow rate threshold range; if the flow rate obtained in real time exceeds the flow rate threshold range, automatically iteratively adjusting the amplitude and frequency to obtain the solvent flow rate optimization adjustment result;

[0080] First, set a velocity threshold range, and determine a suitable velocity upper and lower limit range based on the technical parameters of the equipment and the system's operating requirements. For example, assuming the velocity threshold range is and , are the minimum and maximum flow rates, respectively. Within this range, the flow rate can be automatically adjusted to meet the requirements of extraction efficiency and stability. The current flow rate can be obtained through real-time monitoring , and compare it with the preset threshold range. exceeds the threshold range, i.e. or , it means that the current flow rate does not meet the system requirements and needs to be adjusted. At this time, adjust the flow rate amplitude and frequency according to the flow rate change law within the maximum entropy range. Specifically, if the flow rate is too high or too low, the system will automatically adjust the flow rate amplitude and set the adjustment frequency. According to the analysis of the maximum entropy principle, the amplitude and frequency will be appropriately reduced to avoid frequent flow rate changes. Through this series of adjustments, the solvent flow rate is eventually within the preset threshold range to ensure the stable and efficient operation of the extraction process. For example, if If the flow rate exceeds the maximum value of 5.0 L / min, the system will automatically reduce the adjustment amplitude and frequency, and perform multiple iterative adjustments until the flow rate stabilizes within the threshold range of 5.0 L / min or lower.

[0081] See also Figure 4 , the steps to calculate the value of the objective function are as follows:

[0082] S311: real-time monitoring of changes in the concentration of Chinese medicinal materials components in the solvent flow rate optimization adjustment result, defining an extraction objective function for each Chinese medicinal material according to the changes in the concentration of the Chinese medicinal materials components, quantifying the extraction effect according to the objective function, and obtaining a quantified extraction effect;

[0083] First, real-time monitoring of changes in the concentration of Chinese medicinal materials is achieved by collecting data on the concentration of the active ingredients in the solvent through sensors. The concentration data at each moment is recorded and matched with the time stamp to ensure accurate tracking of the changing trend of the ingredients. The goal-oriented algorithm sets the respective extraction objective functions according to the different components of the medicinal materials. The design basis of the objective function is the change in the concentration of the active ingredients, which reflects the extraction efficiency of the solvent on the components of the Chinese medicinal materials. The algorithm optimizes the extraction process by evaluating the difference between the concentration change of each component and the expected concentration. Specifically, according to the change in the concentration of the Chinese medicinal materials, an ideal concentration value is set, and the parameters such as the solvent flow rate, concentration and temperature are adjusted through the goal-oriented algorithm to maximize the extraction effect. For example, for a certain Chinese medicinal material, the target concentration is set to 2.5 mg / L. When the actual concentration reaches the target concentration, the extraction process is optimized.

[0084] S312: Based on the quantified extraction effect, the formula is used:

[0085] ;

[0086] Calculate the objective function value F, which is used to quantify the deviation between the actual extraction result and the target concentration. It can measure the efficiency of the current Chinese herbal medicine extraction process. The smaller the objective function value, the closer the extraction effect is to the expected target.

[0087] in, The weight coefficient of the jth component is used to indicate the contribution weight of different components to the objective function. Different components of Chinese herbal medicine may contribute to the final extraction effect to different degrees. The importance of each component is reflected by assigning a weight coefficient. It is set through experiments or historical data analysis. For example, if a certain component contributes more to the efficacy, it is given a larger weight, otherwise, it is given a smaller weight. The weight coefficient The value usually ranges from 0 to 1, and the sum of the weight coefficients of all ingredients is 1. For example, if the ingredient directly affects the efficacy or is the most common key ingredient, its weight coefficient should be larger, usually 0.5 to 0.7. For some auxiliary ingredients, although they have a certain effect on the efficacy, they are not the main contributors, their weight coefficients can be set to 0.2 to 0.4. For ingredients that have a smaller effect on the efficacy, or those that contribute very little to the efficacy, the weight coefficient should be lower, usually 0.1 or below. represents the concentration of the jth component at time t. This concentration is obtained through real-time experimental data collection and can be monitored by the solvent flow rate, solvent concentration, and operating conditions of the extraction device. The data acquisition device will record the concentration of each component at each moment and generate a data sequence. It represents the target concentration of the jth component, that is, the target value that is expected to be achieved during the extraction process. The target concentration is set according to the ideal concentration of the active ingredient, usually based on pharmacological research or historical data. For example, in a certain active ingredient, the target concentration may be set to 2.5 mg / L, indicating that the concentration of the ingredient is expected to reach 2.5 mg / L during the extraction process. m represents the number of active ingredients involved in the calculation. Usually in the process of multi-component extraction, in order to comprehensively consider the extraction effects of all components, the objective function needs to consider the concentration changes of each component. The value of this parameter is set by the experiment and can be 2, 3 or more, depending on the number of active ingredients considered during the extraction process.

[0088] If there are three active ingredients, they are , and , the target concentration of each component was set at 2.5 mg / L, and the actual monitored concentrations were: , , , assuming the weight coefficient is: , , .

[0089] Calculate the objective function according to the formula:

[0090] ;

[0091] This result shows that the objective function value It reflects the deviation between the actual extraction results and the set target.

[0092] See also Figure 5 , the specific steps for obtaining the results of the optimization of the extraction time of Chinese medicinal materials are as follows:

[0093] S321: Compare the objective function value with the preset concentration of the active ingredient, and dynamically adjust the extraction time of the Chinese medicinal material extraction device according to the comparison result. If the change in the concentration of the active ingredient exceeds the preset change threshold, the extraction time is extended; if the change in the concentration of the active ingredient is lower than the preset change threshold, the extraction time is shortened to obtain the adjusted extraction effect;

[0094] According to the calculated objective function value , this value can be compared with the preset change threshold. Assuming the preset change threshold of the active ingredient concentration is 0.05mg / L, the following is an analysis of two cases: If the objective function value is greater than the threshold: Assuming the actual calculated objective function value , which is greater than the preset change threshold of 0.05mg / L. This indicates that the concentration of the active ingredient changes greatly, and the concentration of the ingredient does not reach the ideal range during the extraction process. Therefore, the extraction time needs to be extended to increase the concentration of the active ingredient. In this case, the extraction time of the extraction device will be appropriately extended according to the degree of change of the objective function to ensure that the extraction effect reaches the target concentration. If the objective function value is less than the threshold: If the objective function value , which is less than the preset change threshold of 0.05 mg / L, indicating that the concentration of the active ingredient changes little, and the extraction process is close to the ideal state or has reached the expected concentration. In this case, the extraction time of the extraction device can be shortened to avoid over-extraction and reduce unnecessary waste of resources. Through this mechanism, the extraction time can be controlled more accurately to optimize the extraction effect and efficiency. Through this comparison based on the objective function value and the preset threshold, the system can flexibly adjust the extraction time to ensure that the extraction process at each stage can maximize the concentration of the active ingredient and avoid unnecessary over-extraction.

[0095] S322: According to the adjusted extraction effect, check the extension or shortening degree of the extraction time of the Chinese medicinal materials, and adjust it according to the current situation. If the extraction time needs to be extended, it is necessary to extend the extraction time according to the set ratio or time range. If the extraction time needs to be shortened, the extraction time is reduced to obtain the optimization result of the extraction time of the Chinese medicinal materials;

[0096] First, after comparing the objective function value with the preset threshold, if the objective function value is greater than the threshold, the extraction time will be extended; if the objective function value is less than the threshold, the extraction time will be shortened. Based on this adjustment, the system automatically calculates the new extraction time. For example, if the objective function value exceeds the preset threshold ,like , and the threshold is 0.05mg / L, indicating that the concentration of the active ingredient changes greatly, and the extraction time will be extended according to the set expansion ratio (such as 10%). Assuming that the original extraction time is 60 minutes, after extending by 10%, the new extraction time will be 66 minutes. On the contrary, if the objective function value is less than the threshold, such as , it means that the concentration of the active ingredient changes little, and the extraction time can be shortened to avoid unnecessary waste. Assuming that the extraction time is shortened by 10%, the new extraction time will be 54 minutes. Through this method, the system can flexibly adjust the extraction time to ensure that each Chinese herbal medicine extraction process will not waste too much time and can achieve the optimal concentration of active ingredients, thereby improving the overall extraction efficiency and maintaining the stability of the efficacy.

[0097] See also Figure 6 The steps to predict the future adjustment needs of active ingredients are as follows:

[0098] S411: Based on the solvent flow rate optimization adjustment result and the Chinese medicinal material extraction time optimization result, compare the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredient, and determine whether it exceeds the preset active ingredient concentration change threshold, and generate the solvent flow rate and extraction time adjustment effect evaluation result;

[0099] First, by comparing the changes in solvent flow rate and extraction time before and after adjustment, evaluate the impact on the concentration of active ingredients. In the actual extraction process, changes in solvent flow rate will affect the contact time and efficiency of the solvent and medicinal materials, and then affect the extraction concentration of the active ingredients. If after optimization and adjustment, the solvent flow rate increases from the original 4L / min to 5L / min, and the extraction time is reduced by 10%, it is necessary to analyze its effect through real-time monitoring of concentration data. Assuming that the preset threshold value of the change in the concentration of the active ingredient is 0.1mg / L, if the change in the concentration of the active ingredient after adjustment is greater than the threshold, it means that the optimized flow rate and time settings help to improve the extraction effect. If the change is less than the threshold or the concentration decreases, it means that the extraction effect is not as expected. If the concentration of the active ingredient increases a lot (for example, the increase exceeds 0.2mg / L), it means that this optimization scheme is effective and should continue to be used; if the increase is small or the concentration decreases, the adjusted flow rate and extraction time may not be appropriate and need further adjustment. For example, if the concentration after flow rate adjustment is increased to 0.15 mg / L (between 0.1 and 0.2 mg / L), other factors (such as solvent concentration or medicinal material type) need to be considered and a decision needs to be made as to whether to continue optimization.

[0100] S412: Based on the evaluation results of the solvent flow rate and extraction time adjustment effect, the formula is used:

[0101] ;

[0102] Calculate the concentration of active ingredients at a future time based on the current concentration change and time interval , according to the concentration of the active ingredient at a future time Analyze the change trend and obtain the analysis results of the future change trend of drug efficacy;

[0103] in, It represents the concentration of the active ingredient at the current time t, which is obtained through real-time monitoring. For example, the concentration of the active ingredient in the solvent is monitored using experimental equipment, and the value is recorded at each time point. This data can be obtained through an online concentration sensor or measured by a laboratory analysis method. It indicates the rate at which the concentration of the active ingredient changes over time. This value indicates the change in the concentration of the active ingredient over a period of time. It indicates the change in the concentration of the active ingredient within a certain time interval, and is the length of the time interval. For example, if the concentration at time t is known to be , and observe that at the next moment ( ) becomes , then the change in concentration can be expressed as , which represents the change in the concentration of the active ingredient. Indicates a time interval. Usually, it is assumed that the time interval is very small, so that the approximate differential formula can be used to calculate the instantaneous rate of change of concentration with time, for example, if the recorded data are from consecutive time points, It is the time difference between these consecutive time points, usually in minutes or seconds. It represents the prediction time interval, which refers to the time difference from the current time t to the future time. This parameter is usually determined by the experimental design or the schedule of the extraction process, and is assumed to be 10 minutes.

[0104] If at time t, the concentration of the active ingredient is monitored The concentration change rate is , and the prediction time interval , then calculate according to the formula:

[0105] ;

[0106] The results showed that the concentration of the active ingredient was expected to increase from 2.3 mg / L to 2.8 mg / L in the next 10 minutes.

[0107] See also Figure 7 The specific steps of the dynamic adjustment result of the Chinese herbal medicine extraction device are:

[0108] S421: Based on the analysis results of the future trend of drug efficacy, the influence of the adjusted solvent flow rate and extraction time on the concentration of the drug efficacy component is analyzed, and according to the trend of concentration change, it is determined whether the extraction time or flow rate needs to be further adjusted, and the evaluation results of the trend of drug efficacy component concentration change are generated;

[0109] First, the system will determine whether the extraction parameters need to be adjusted based on the changing trend of the concentration of the active ingredient. For example, suppose the target concentration of the active ingredient is 2.5 mg / L, the current concentration is 2.0 mg / L, and the concentration change rate is 0.1 mg / L per minute. When the concentration growth rate is greater than 0.05 mg / L / min and the concentration is not yet close to the target concentration, the system will increase the solvent flow rate or extend the extraction time to speed up the extraction process. If the concentration growth rate is lower than 0.05 mg / L / min and the concentration is close to the target concentration, the system will reduce the solvent flow rate or shorten the extraction time to avoid over-extraction. If the concentration does not increase significantly within a certain period of time, the system will increase the flow rate (for example, to 4 L / min) or increase the temperature (for example, to 60 ° C) to promote the extraction of the active ingredient and ensure that the concentration reaches the expected target.

[0110] S422: Based on the evaluation result of the concentration change trend of the active ingredient, the corresponding parameters in the medicinal material extraction process are adjusted to obtain the dynamic adjustment result of the Chinese medicinal material extraction device;

[0111] When adjusting parameters such as flow rate, extraction time and temperature, the system will first consider the current trend of changes in the concentration of active ingredients. If the concentration increase is close to the preset target (for example, the concentration change is within 0.1mg / L), the system will choose to moderately reduce the solvent flow rate (for example, from 5L / min to 4.5L / min) or shorten the extraction time (for example, reduce the extraction time by 5%). If the concentration change is greater than 0.2mg / L, it means that the extraction process is very effective, and the system may reduce the extraction time to 90% of the original time to avoid over-extraction. If the concentration change is small (less than 0.05mg / L), the system will increase the flow rate (for example, increase to 6L / min) or extend the extraction time (increase by 10%) to promote the extraction of active ingredients and ensure that the final active ingredient concentration meets the target concentration. These dynamic adjustments will ensure that the extraction process of Chinese herbal medicines remains efficient and accurate, and ultimately generate corresponding adjustment results.

[0112] A dynamic adjustment system for a Chinese medicinal material extraction device, the dynamic adjustment system for a Chinese medicinal material extraction device is used to execute the dynamic adjustment method for the Chinese medicinal material extraction device, the system comprising:

[0113] The solvent flow rate adjustment module obtains parameter data during the extraction process of Chinese medicinal materials, divides it into fixed moments, calculates the entropy value of the parameters at each moment, analyzes the entropy value change trend, evaluates the solvent flow rate adjustment space, and generates the solvent flow rate dynamic adjustment evaluation results;

[0114] The optimal flow rate range determination module determines the optimal solvent flow rate range by analyzing the evaluation results of the dynamic adjustment of the solvent flow rate, limits the flow rate adjustment amplitude and frequency, and generates the solvent flow rate optimization adjustment results;

[0115] The extraction time adjustment module monitors the changes in component concentrations in the solvent flow rate optimization adjustment results in real time, calculates the objective function and compares it with the preset concentration of the active ingredient, and dynamically adjusts the extraction time according to the comparison results to generate the optimization results of the extraction time of Chinese herbal medicines;

[0116] The overall optimization and adjustment module analyzes the solvent flow rate optimization adjustment results and the Chinese medicinal materials extraction time optimization results, evaluates the impact of the flow rate and extraction time adjustments on the concentration of active ingredients, predicts future adjustment needs, adjusts the parameters during the extraction process, and generates dynamic adjustment results for the Chinese medicinal materials extraction device.

[0117] The above are only preferred embodiments of the present invention and are not intended to limit the present invention in other forms. Any technician familiar with the profession may use the technical contents disclosed above to change or modify them into equivalent embodiments with equivalent changes and apply them to other fields. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A dynamic adjustment method for a Chinese medicinal material extraction device, characterized in that: The following steps are involved: S1: Obtain the parameters of the Chinese herbal medicine extraction device during the extraction process, divide the parameters according to fixed time, calculate the entropy value of the corresponding parameters at each time, evaluate the solvent flow rate adjustment space according to the entropy value change trend, and generate the solvent flow rate dynamic adjustment evaluation result; S2: Analyzing the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, automatically limiting the amplitude and frequency of the flow rate adjustment in the Chinese medicinal material extraction device with reference to the optimal solvent flow rate range, and obtaining the solvent flow rate optimization adjustment result; S3: Real-time monitoring of the concentration changes of the Chinese medicinal material components in the solvent flow rate optimization adjustment result, defining the extraction objective function of each Chinese medicinal material, calculating the value of the objective function, and comparing the value of the objective function with the preset concentration of the active ingredient, dynamically adjusting the extraction time of the Chinese medicinal material extraction device according to the comparison result, and generating the Chinese medicinal material extraction time optimization result; S4: Analyze the optimization adjustment results of the solvent flow rate and the optimization results of the Chinese medicinal material extraction time, the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredients, predict the future adjustment needs of the active ingredients, adjust the corresponding parameters in the medicinal material extraction process according to the future adjustment needs, and obtain the dynamic adjustment results of the Chinese medicinal material extraction device.

2. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 1, characterized in that: The steps for obtaining the evaluation result of the dynamic adjustment of the solvent flow rate are specifically as follows: S111: Obtaining the solvent flow rate, solvent concentration, and solvent temperature parameters during the medicinal material extraction process of the Chinese medicinal material extraction device, dividing the parameters during the medicinal material extraction process according to fixed time points, and obtaining a medicinal material extraction data division result; S112: Based on the result of the division of the medicinal material extraction data, the formula is used: ； Calculate the entropy value of the corresponding parameter at each time t ; in, represents the probability distribution of the i-th parameter at time t, represents the change of the i-th parameter between the previous and next moments, represents the adjustment coefficient, and n represents the number of parameters involved in the calculation; S113: By comparing the entropy value change trend of the corresponding parameter at each moment, the solvent flow rate adjustment space is evaluated according to the entropy value change trend, and the solvent flow rate dynamic adjustment evaluation result is generated.

3. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 2, characterized in that: The steps for obtaining the solvent flow rate optimization adjustment result are specifically as follows: S211: analyzing the optimal solvent flow rate range in the evaluation result of the dynamic adjustment of the solvent flow rate by the maximum entropy principle, automatically limiting the amplitude and frequency of the flow rate adjustment in the Chinese medicinal material extraction device with reference to the optimal solvent flow rate range, and obtaining the amplitude and frequency of the flow rate adjustment after limitation; S212: Compare the amplitude and frequency of the flow rate adjustment after limitation with the instantaneous flow rate and the preset flow rate threshold range to determine whether the current flow rate is within the flow rate threshold range; if the instantaneous flow rate exceeds the flow rate threshold range, automatically perform iterative adjustment of the amplitude and frequency to obtain the solvent flow rate optimization adjustment result.

4. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 3, characterized in that: The steps of calculating the value of the objective function are specifically as follows: S311: real-time monitoring of the concentration changes of the Chinese medicinal materials in the solvent flow rate optimization adjustment result, defining the extraction objective function of each Chinese medicinal material according to the concentration changes of the Chinese medicinal materials, quantifying the extraction effect according to the objective function, and obtaining the quantified extraction effect; S312: Based on the quantified extraction effect, the formula is used: ； Calculate the objective function value F; in, represents the weight coefficient of the jth component, represents the concentration of the jth component at time t, represents the target concentration of the jth component, and m represents the number of active ingredients involved in the calculation.

5. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 4, characterized in that: The steps for obtaining the optimization result of the extraction time of Chinese medicinal materials are specifically as follows: S321: Compare the objective function value with the preset concentration of the active ingredient, and dynamically adjust the extraction time of the Chinese medicinal material extraction device according to the comparison result. If the concentration change of the active ingredient exceeds the preset change threshold, the extraction time is extended; if the concentration change of the active ingredient is lower than the preset change threshold, the extraction time is shortened to obtain the adjusted extraction effect; S322: According to the adjusted extraction effect, check the degree of extension or shortening of the extraction time of the Chinese medicinal materials, and adjust it according to the current situation. If the extraction time needs to be extended, it is necessary to extend the extraction time according to the set ratio or time range. If the extraction time needs to be shortened, reduce the extraction time to obtain the optimization result of the extraction time of the Chinese medicinal materials.

6. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 5, characterized in that: The steps of predicting the future adjustment requirements of the active ingredient are specifically as follows: S411: Based on the solvent flow rate optimization adjustment result and the Chinese medicinal material extraction time optimization result, compare the influence of the flow rate and extraction time before and after the adjustment on the concentration of the active ingredient, and determine whether it exceeds the preset active ingredient concentration change threshold, and generate the solvent flow rate and extraction time adjustment effect evaluation result; S412: Based on the evaluation results of the solvent flow rate and extraction time adjustment effect, the formula is used: ； Calculate the concentration of active ingredients at a future time based on the current concentration change and time interval , according to the concentration of the active ingredient at a future time Analyze the change trend and obtain the analysis results of the future change trend of drug efficacy; in, represents the concentration of the active ingredient at the current time t, It indicates the rate at which the concentration of the active ingredient changes with time. It represents the prediction time interval, which refers to the time difference from the current time t to the future time.

7. The dynamic adjustment method of the Chinese medicinal material extraction device according to claim 6, characterized in that: The steps of dynamically adjusting the result of the Chinese medicinal material extraction device are specifically as follows: S421: Based on the analysis result of the future change trend of the efficacy, analyzing the influence of the adjusted solvent flow rate and extraction time on the concentration of the active ingredient, and judging whether it is necessary to continue to adjust the extraction time or flow rate according to the change trend of the concentration, and generating an evaluation result of the change trend of the active ingredient concentration; S422: Based on the evaluation result of the concentration change trend of the active ingredient, the corresponding parameters in the medicinal material extraction process are adjusted to obtain the dynamic adjustment result of the Chinese medicinal material extraction device.

8. A dynamic adjustment system for a Chinese herbal medicine extraction device, characterized in that: According to the dynamic adjustment method of the Chinese medicinal material extraction device according to any one of claims 1 to 7, the system comprises: The solvent flow rate adjustment module obtains parameter data during the extraction process of Chinese medicinal materials, divides it into fixed moments, calculates the entropy value of the parameters at each moment, analyzes the entropy value change trend, evaluates the solvent flow rate adjustment space, and generates the solvent flow rate dynamic adjustment evaluation results; The optimal flow rate range determination module determines the optimal solvent flow rate range by analyzing the solvent flow rate dynamic adjustment evaluation result, limits the flow rate adjustment amplitude and frequency, and generates the solvent flow rate optimization adjustment result; The extraction time adjustment module monitors the concentration changes of the components in the solvent flow rate optimization adjustment result in real time, calculates the objective function and compares it with the preset concentration of the active ingredient, and dynamically adjusts the extraction time according to the comparison result to generate the optimization result of the extraction time of the Chinese herbal medicine; The overall optimization and adjustment module analyzes the solvent flow rate optimization adjustment results and the Chinese medicinal material extraction time optimization results, evaluates the impact of the adjustment of the flow rate and extraction time on the concentration of the active ingredients, predicts future adjustment needs, adjusts the parameters during the extraction process, and generates dynamic adjustment results of the Chinese medicinal material extraction device.

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