Preparation method for improving content of index components of snakegourd seed paste powder and formula granules
Through two cycle extraction method and low-temperature vacuum concentration technology, combined with the use of specific auxiliary materials, the low content and wall sticking problems of Trichosanthes seed paste powder are solved, and high-content and high-quality Trichosanthes seed paste powder is achieved, and the effective ingredients are maintained during storage.
Patent Information
- Application Number
- CN202411947331.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-27
- Publication Date
- 2025-03-25
AI Technical Summary
In the existing preparation methods for Trichosanthes seeds, the paste content is low, the product quality is poor, and the oil-containing components stick to the wall during spray drying are severely sticking to each other and the powder is produced less, so the active ingredient content will also be reduced during storage.
The supernatant was extracted from above the extraction tank by two cycles, and then combined, and concentrated under low temperature under vacuum. A specific ratio of dextrin, maltodextrin and silica were added as auxiliary materials, and spray-dried directly to prepare Trichosanthes seed paste powder.
The content of index ingredients in Trichosanthes seed paste powder is improved, the product quality is improved, the phenomenon of sticking to the wall is reduced, the spray drying is smooth, and the content of active ingredient is maintained during storage.
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Abstract
Description
Technical Field
[0001] The invention relates to the field of traditional Chinese medicine preparation, and in particular to a preparation method for improving the content of index components of trichosanthes fruit paste powder and formula granules. Background Art
[0002] Trichosanthes kirilowii Maxim. or Trichosanthes rosthornii Harms, a plant of the Cucurbitaceae family, are dried and mature seeds, which have the effects of moistening the lungs, resolving phlegm, and lubricating the intestines and relieving constipation.
[0003] Trichosanthes seeds mainly contain terpenes and their glycosides, flavonoids and their glycosides, oils, organic acid compounds and other ingredients. Among them, triterpenes are the main active ingredients of Trichosanthes seeds, and 3,29-dibenzoyltriol is the main substance in triterpenes. It has anti-platelet aggregation effect, can inhibit platelet activation, reduce the risk of blood coagulation, and help prevent thrombotic diseases. It may play a role in preventing myocardial infarction, cerebral infarction and other diseases caused by thrombosis. It also has a certain anti-inflammatory effect, can reduce the inflammatory response, and intervene in the disease process related to inflammation.
[0004] Traditional decoction is a dosage form used in clinical practice under the guidance of TCM theory, with thousands of years of human experience. The industrial production of Chinese medicine extraction developed in modern times is a modern application of traditional decoctions, which ultimately acts on patients in the form of oral and injection dosage forms, and is the development and inheritance of Chinese medicine.
[0005] The most commonly used water extraction equipment in the industrial production of Chinese medicine extraction is the multifunctional extraction tank, which mostly uses gravity to release the medicinal liquid from the bottom of the extraction tank. The medicinal residue cannot pass through the screen at the bottom of the tank and is retained in the extraction tank, thus completing the separation operation of the medicinal liquid and the medicinal residue in the extraction tank; there are also those that use industrial pumps to discharge the liquid from the bottom or centrifuge to complete the separation operation of the medicinal liquid and the medicinal residue.
[0006] The existing method for preparing the seeds of Trichosanthes kirilowii is to extract them in a multifunctional extraction tank, separate the medicinal liquid and the medicinal residue by filtering, and then concentrate and dry them. The obtained paste powder has low content and poor product quality.
[0007] At the same time, since Trichosanthes seeds contain more oil components, the paste powder sticks to the wall seriously during the spray drying process and the powder output is less.
[0008] Prior art has been to prepare Chinese medicine extract paste powder by separating the oil components separately and then encapsulating and drying them with beta-cyclodextrin as an auxiliary material. However, the paste powder prepared by this method has a low content of effective ingredients, and the content of the effective ingredients will be significantly reduced during the later storage period. Summary of the invention
[0009] In view of the above problems, the present invention provides a preparation method for improving the content of index components in Trichosanthes fruit paste powder and formula granules.
[0010] To achieve the above purpose, the technical solution adopted by the present invention is:
[0011] A preparation method for improving the content of index components of trichosanthes seed paste powder, the preparation method for improving the content of index components of trichosanthes seed paste powder is to take trichosanthes seed slices and water and add them to an extraction tank, perform two cycles of extraction, extract supernatant from the top of the extraction tank after each extraction, combine the two extracted supernatants, and then concentrate, add dextrin, maltodextrin and silicon dioxide mixed auxiliary materials to the obtained concentrated solution, stir evenly, and directly spray dry to obtain the trichosanthes seed paste powder;
[0012] Extracting the supernatant from the top of the extraction tank is to extract the supernatant from the top of the extraction tank, and transfer the extracted supernatant (i.e., drug solution) to the drug solution storage tank via a diaphragm pump / vacuum pump, thereby completing the separation operation of the drug solution and drug residue in the extraction tank.
[0013] Furthermore, the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials is 1:1-4:0.28-0.32.
[0014] Furthermore, the weight ratio of the auxiliary material added to the concentrated solution to the Trichosanthes fruit slices is 0.75-1.00:10.
[0015] Furthermore, the preparation method for increasing the content of index components in the Trichosanthes fruit paste powder comprises the following steps:
[0016] S1, add drinking water to the extraction tank, heat it, put in the Fructus Trichosanthis decoction pieces, carry out the first cycle extraction, after the extraction is completed, extract the supernatant from the top of the extraction tank to obtain one medicine solution;
[0017] S2, after the extraction of the medicinal liquid is completed, drinking water is added to the remaining medicinal residue for the second time, and after heating, a second cycle extraction is performed. After the extraction is completed, the supernatant is extracted from the top of the extraction tank again to obtain the second extraction medicinal liquid;
[0018] S3, combining the first extraction liquid and the second extraction liquid, and performing low-temperature vacuum concentration, and after the concentration is completed, a concentrated solution is obtained;
[0019] S4, mixing dextrin, maltodextrin and silicon dioxide to obtain auxiliary materials;
[0020] The concentrated solution is added with auxiliary materials, stirred and mixed evenly, and then directly spray-dried without inclusion to obtain the Trichosanthes fruit paste powder.
[0021] Furthermore, in step S3, the temperature of low-temperature vacuum concentration is 60 to 70°C and the vacuum degree is -0.04 to -0.10 MPa.
[0022] Furthermore, the concentrated solution has a concentrated density of 1.00 to 1.04.
[0023] Furthermore, during the two cycles of extraction, the amount of water used was 10 to 20 times the weight of the Trichosanthes fruit slices.
[0024] Furthermore, the temperature of the two extraction cycles is 95-100° C., the time of the first extraction cycle is 0.7-1 h, and the time of the second extraction cycle is 0.5-1 h.
[0025] A preparation method for improving the content of index components of trichosanthes fruit formula granules, the preparation method for improving the content of index components of trichosanthes fruit formula granules comprises mixing trichosanthes fruit paste powder prepared by the preparation method for improving the content of index components of trichosanthes fruit paste powder with auxiliary materials for granules, and preparing the trichosanthes fruit formula granules through dry granulation.
[0026] Furthermore, the auxiliary material for the granules is prepared by mixing dextrin and lactose in a weight ratio of 1:1.3-2.5;
[0027] The weight ratio of the trichosanthes seed paste powder to the auxiliary materials for the granules is 1:0.06-0.08.
[0028] The beneficial effects of the preparation method of the present invention for improving the content of index components of Trichosanthes fruit paste powder and formula granules are:
[0029] The present invention firstly finds that the traditional decoction of Trichosanthes fruit extracts the liquid from the top and the modern process extracts the liquid from the bottom of the extraction equipment through the drug residue, which affects the content of the active ingredient 3,29-dibenzoyl trichosanthes ...
[0030] Specifically, the present invention extracts the supernatant from the top of the extraction tank and pumps it into the liquid medicine storage tank through a diaphragm pump / vacuum pump, rather than releasing the medicine from the bottom of the tank through the medicine residue. Due to the filtering method without releasing the liquid through the medicine residue, the content of the Trichosanthes fruit paste powder and the finished product is effectively increased;
[0031] Furthermore, the present invention selects dextrin, maltodextrin and silicon dioxide in a specific ratio as auxiliary materials to prepare the Trichosanthes fruit paste powder, and can directly prepare the Trichosanthes fruit paste powder without inclusion under the premise of effectively reducing the amount of auxiliary materials, and the prepared Trichosanthes fruit paste powder has high content and good fluidity, and is suitable for preparing Trichosanthes fruit formula granules;
[0032] At the same time, the Trichosanthes seeds formula granules prepared by the present invention not only have high content, but also have good fluidity and stability;
[0033] The invention improves the fluidity of the trichosanthes seed paste powder by adding specific auxiliary materials, reduces the sticking of the paste powder to the wall due to excessive oil components, ensures smooth spray drying, and the prepared trichosanthes seed paste powder is convenient for granulation and molding in subsequent processes, the obtained product quality is better, the yield is improved, and good economic benefits are achieved;
[0034] In addition, since the content of the index component of Trichosanthes fruit is 3,29-dibenzoyl trichosanthes triol (C 44 H 58 O5), a pentacyclic triterpenoid compound, has an oleanane-type structure, has strong intrinsic activity within the molecule, and will be converted into an unknown component C due to the loss of two hydrogen atoms during long-term heating during the production process. 44 H 56 O5((3α,20α)-3,29-Bis(benzoyloxy)-13-methyl-26-norolean-8-en-7-one), resulting in a decrease in the content of the components; the present invention adopts a low-temperature vacuum concentration method to effectively control the concentration temperature at 60-70°C, thereby reducing the decomposition of the target components and further increasing the content of the target components in the paste powder. DETAILED DESCRIPTION
[0035] The technical solutions in the embodiments of the present invention are described clearly and completely below. In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention can also be implemented in other ways different from those described herein, and those skilled in the art can make similar generalizations without violating the connotation of the present invention, so the present invention is not limited by the specific embodiments disclosed below.
[0036] Example 1 A preparation method for improving the content of index components of Trichosanthes fruit powder and formula granules
[0037] This embodiment is a preparation method for improving the content of index components of Trichosanthes fruit paste powder and formula granules, and the specific preparation process includes the following steps:
[0038] S1, add 150kg of drinking water to the extraction tank, heat it to 100°C, weigh 10kg of Trichosanthes fruit slices and put them in, heat it to 100°C, perform the first cycle extraction at 100°C for 1h, after the extraction is completed, extract the supernatant from the top of the extraction tank, and extract the liquid medicine from the top of the extraction tank into the liquid medicine storage tank through a diaphragm pump / vacuum pump to obtain one lift of liquid medicine;
[0039] S2. After the extraction of the medicinal liquid is completed, 150 kg of drinking water is added to the remaining medicinal residue for the second time, and after heating to 100 ° C, a second cycle extraction is performed for 1 hour. After the extraction is completed, the supernatant is extracted from the top of the extraction tank again, and the medicinal liquid is extracted from the top of the extraction tank to the medicinal liquid storage tank by a diaphragm pump / vacuum pump, completing the separation operation of the medicinal liquid and the medicinal residue in the extraction tank to obtain the second extraction medicinal liquid;
[0040] S3, combining the first extraction liquid and the second extraction liquid, transferring them to a vacuum concentration tank, and performing low-temperature vacuum concentration at 65°C and -0.10MPa. After the concentration is completed, a concentrated solution is obtained, and the density of the concentrated solution is 1.04;
[0041] S4, mixing dextrin, maltodextrin and silicon dioxide in a weight ratio of 1:2:0.3 to obtain an auxiliary material;
[0042] The concentrate was added with 0.88 kg of auxiliary materials, stirred at room temperature and 50 r / min for 60 min until the mixture was uniformly mixed, and then directly spray-dried without inclusion to obtain 1.92 kg of Trichosanthes fruit powder, which was marked as Y1;
[0043] S5. Mix dextrin and lactose in a weight ratio of 1:2 to obtain auxiliary materials for granules;
[0044] Take 1 kg of Trichosanthes fruit powder Y1, add 0.07 kg of granules and auxiliary materials to mix evenly, and granulate by dry method to obtain Trichosanthes fruit granules, marked as G1, with a granulation rate of 99.4%.
[0045] Embodiments 2 to 5 Preparation methods for improving the content of index components of Trichosanthes fruit powder and formula granules
[0046] Examples 2 to 5 are respectively a preparation method for improving the content of index components of Trichosanthes fruit paste powder and formula granules, and their steps are basically the same as those of Example 1, and the only difference is the different raw material dosage and process parameters, as shown in Table 1 for details:
[0047] Table 1 List of process parameters in Examples 2 to 5
[0048]
[0049]
[0050] The other parts of Examples 2 to 5 are the same as those of Example 1 and will not be described again.
[0051] Experimental Example 1 Experimental Measurement
[0052] Comparative Examples 1 to 9 are comparative tests of the preparation method for improving the content of index components of the Trichosanthes fruit paste powder and the formula granules in Example 1, and the Trichosanthes fruit of the same batch as that of Example 1 is used as the raw material, and the steps are basically the same as those of Example 1, except that:
[0053] In Comparative Example 1, only step S2 obtains one extract of medicinal liquid by traditional filtration instead of extraction, and step S3 obtains two extracts of medicinal liquid by traditional filtration instead of extraction, which is different from Example 1. Apart from this, other process steps, parameters and raw material dosages are the same as those in Example 1, and 1.50 kg of Trichosanthes fruit paste powder is obtained, marked as DY1; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY1 are marked as DG1, and the granulation rate is 98.5%.
[0054] In Comparative Example 2, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 1:0.1:0.3, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.66 kg of Trichosanthes fruit paste powder is obtained, marked as DY2; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY2 are marked as DG2, and the granulation rate is 99.3%.
[0055] In Comparative Example 3, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 1:10:0.3, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.42 kg of Trichosanthes fruit paste powder is obtained, marked as DY3; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY3 are marked as DG3, and the granulation rate is 96.1%.
[0056] In Comparative Example 4, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 0.1:2:0.3, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.60 kg of Trichosanthes fruit paste powder is obtained, marked as DY4; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY4 are marked as DG4, and the granulation rate is 99.2%.
[0057] In Comparative Example 5, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 5:2:0.3, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.48 kg of Trichosanthes fruit paste powder is obtained, marked as DY5; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY5 are marked as DG5, and the granulation rate is 96.4%.
[0058] In Comparative Example 6, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 1:2:0.1, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.40 kg of Trichosanthes fruit paste powder is obtained, marked as DY6; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY6 are marked as DG6, and the granulation rate is 96.0%.
[0059] In Comparative Example 7, only the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials of step S5 is 1:2:1, which is different from Example 1. Apart from this, the amount of auxiliary materials and other process steps, parameters and raw material amounts are the same as those in Example 1, and 1.65 kg of Trichosanthes fruit paste powder is obtained, marked as DY7; the Trichosanthes fruit granules prepared using Trichosanthes fruit DY7 are marked as DG7, and the granulation rate is 99.6%.
[0060] The specific steps of Comparative Example 8 are as follows:
[0061] S1. Add 15 kg of drinking water to the extraction tank, heat it to 100°C, and weigh 1 kg of Trichosanthes fruit slices;
[0062] S2, after heating to 100°C, perform the first cycle extraction at 100°C for 1 hour. After the extraction is completed, extract the supernatant from the top of the extraction tank, and extract the drug solution from the top of the extraction tank into the drug solution storage tank via a diaphragm pump / vacuum pump to obtain one-liter drug solution;
[0063] S3. After the extraction of the medicinal liquid is completed, 15 kg of drinking water is added to the remaining medicinal residue for the second time, and after heating to 100 ° C, a second cycle extraction is performed for 1 hour. After the extraction is completed, the supernatant is extracted from the top of the extraction tank again, and the medicinal liquid is extracted from the top of the extraction tank to the medicinal liquid storage tank by a diaphragm pump / vacuum pump, completing the separation operation of the medicinal liquid and the medicinal residue in the extraction tank to obtain the second extraction medicinal liquid;
[0064] S4, combining the first extraction liquid and the second extraction liquid, transferring them to a vacuum concentration tank, and performing low-temperature vacuum concentration at 65°C and -0.10MPa. After the concentration is completed, a concentrated solution is obtained, and the density of the concentrated solution is 1.04;
[0065] S5. Add 0.22 kg of β-cyclodextrin to the concentrated solution, stir and mix at a speed of 40 r / min for 7 minutes at room temperature, and emulsify by centrifugal method through shearing, grinding and high-speed stirring in a colloid mill to obtain an emulsified drug solution; wherein, the speed of the colloid mill is 2530 r / min and the emulsification fineness is 30 μm.
[0066] The emulsified liquid was pumped into the liquid preparation tank of the spray drying tower, 0.66 kg of dextrin was added as a binder, and the mixture was stirred at 50 r / min at room temperature for 1 h until uniformly stirred. The resulting paste powder aqueous solution was spray dried and granulated to obtain 1.33 kg of Trichosanthes fruit paste powder, which was marked as DY8.
[0067] S6. Mix dextrin and lactose in a weight ratio of 1:2 to obtain an auxiliary material for granules;
[0068] Take 1 kg of Trichosanthes fruit powder DY8, add 0.07 kg of granular auxiliary materials, and granulate by dry method to obtain Trichosanthes fruit granules, marked as DG8, with a granulation rate of 94.2%.
[0069] The specific steps of Comparative Example 9 are as follows:
[0070] S1. Add 15 kg of drinking water to the extraction tank, heat it to 100°C, and weigh 1 kg of Trichosanthes fruit slices;
[0071] S2, after heating to 100°C, perform the first cycle extraction at 100°C for 1 hour. After the extraction is completed, extract the supernatant from the top of the extraction tank, and extract the drug solution from the top of the extraction tank into the drug solution storage tank via a diaphragm pump / vacuum pump to obtain one-liter drug solution;
[0072] S3. After the extraction of the medicinal liquid is completed, 15 kg of drinking water is added to the remaining medicinal residue for the second time, and after heating to 100 ° C, a second cycle extraction is performed for 1 hour. After the extraction is completed, the supernatant is extracted from the top of the extraction tank again, and the medicinal liquid is extracted from the top of the extraction tank to the medicinal liquid storage tank by a diaphragm pump / vacuum pump, completing the separation operation of the medicinal liquid and the medicinal residue in the extraction tank to obtain the second extraction medicinal liquid;
[0073] S4, combining the first extraction liquid and the second extraction liquid, transferring them to a vacuum concentration tank, and performing low-temperature vacuum concentration at 65°C and -0.10MPa. After the concentration is completed, a concentrated solution is obtained, and the density of the concentrated solution is 1.04;
[0074] S5. Mix dextrin, maltodextrin and silicon dioxide in a weight ratio of 1:2:0.3 to obtain an auxiliary material;
[0075] Add 0.88 kg of auxiliary materials to the concentrated solution, stir and mix at a speed of 40 r / min for 7 minutes at room temperature, and emulsify by centrifugation through shearing, grinding and high-speed stirring in a colloid mill to obtain an emulsified drug solution; wherein, the speed of the colloid mill is 2530 r / min and the emulsification fineness is 30 μm.
[0076] The emulsified liquid was pumped into the liquid preparation tank of the spray drying tower, and stirred at a speed of 50 r / min at room temperature for 1 hour until uniformly stirred. The resulting paste powder aqueous solution was spray dried and granulated to obtain 1.65 kg of Trichosanthes fruit paste powder, which was marked as DY9.
[0077] S6. Mix dextrin and lactose in a weight ratio of 1:2 to obtain an auxiliary material for granules;
[0078] Take 1 kg of Trichosanthes fruit powder DY9, add 0.07 kg of granular auxiliary materials, and granulate by dry method to obtain Trichosanthes fruit granules, marked as DG9, with a granulation rate of 99.2%.
[0079] Furthermore, the content, content transfer rate, angle of repose and stability of 3,29-dibenzoyl trichosanthes triol were determined as follows:
[0080] The 3,29-dibenzoyltriol content, content transfer rate, repose angle and stability of the Guaruzou Seed Formula Granules G1-G5 and DG1-DG9 prepared in Examples 1-5 and Comparative Examples 1-9 were respectively measured.
[0081] The content determination method of 3,29-dibenzoyl trichosanthes trichosanthes in the formula granules of Trichosanthes fruit was determined according to the method recorded in the Trichosanthes fruit of the Chinese Pharmacopoeia (2020 edition) in the first volume of medicinal materials and decoction pieces; the angle of repose was determined by the fixed funnel method;
[0082] The content transfer rate is calculated by the following method, and the calculation formula is as follows:
[0083] Content transfer rate (%) = content of finished product (g / g) × paste yield / medicinal material content × 100%;
[0084] The ointment yields of the above-mentioned embodiments and comparative examples were calculated after supplementing the equivalent according to the national standard, and the ointment yields were both 14.08%, and the medicinal material content was calculated according to the pharmacopoeia requirement of 0.08%.
[0085] Therefore, the content transfer rate (%) of 3,29-dibenzoyl trichosanthes ...
[0086] The stability determination method is as follows: the Gua Ruo Zi formula granules in Examples 1 to 5 and Comparative Examples 1 to 7 are placed under long-term test conditions (temperature 25° C., relative humidity 60%) for 1, 3, and 5 months, respectively, and the content of the index components is determined according to the content determination method of the Gua Ruo Zi formula granules.
[0087] The specific results are shown in Table 2 and Table 3:
[0088] Table 2 List of test results of Trichosanthes fruit formula granules
[0089]
[0090]
[0091] Table 3 Summary of stability results of Trichosanthes fruit formula granules
[0092] Group Long-term 1-month content (mg / g) Long-term 3-month content (mg / g) Long-term 5-month content (mg / g) Example 1 0.39 0.38 0.37 Example 2 0.38 0.37 0.36 Example 3 0.34 0.33 0.32 Example 4 0.37 0.36 0.35 Example 5 0.36 0.35 0.34 Comparative Example 1 0.20 0.19 0.18 Comparative Example 2 0.31 0.30 0.28 Comparative Example 3 0.30 0.29 0.27 Comparative Example 4 0.33 0.32 0.30 Comparative Example 5 0.29 0.28 0.27 Comparative Example 6 0.28 0.27 0.25 Comparative Example 7 0.28 0.26 0.25 National standard requirements 0.17-0.83 (mg / g) 0.17-0.83 (mg / g) 0.17-0.83 (mg / g)
[0093] It can be seen from Tables 2 and 3 that when the weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials is too large or too small, the content and content transfer rate show a decreasing trend, the proportion of silicon dioxide in the auxiliary materials increases, and the angle of repose of the formula particles basically shows a decreasing trend, indicating that silicon dioxide has a good effect on improving fluidity. From the stability results, the content of the Trichosanthes seeds particles in Examples 1 to 5 decreases slightly in the long term of 1, 3, and 5 months, and the decrease ratio in 5 months is about 8%, which has good stability; the content of Comparative Examples 1 to 7 decreases more significantly than in the examples, and the decrease ratio in 5 months is about 15%.
[0094] From the comparison data of Example 1 and Comparative Example 1, it can be seen that the content of the extract through the slag is about 50% lower than that of the extract from the top. The reason is considered to be the "liquid-slag filter cake effect". When the extract passes through the solid layer formed by the accumulation of slag, the filter cake composed of fine slag is easy to adsorb effective ingredients due to the small slag particles, small pores, and large specific surface area. As the filter cake continues to thicken, the resistance to filtration will become larger and larger, and the speed of the extract passing through the slag will become slower and slower. The oil components in the fruit of Trichosanthes adhere to the surface of the aggregated slag filter cake, and the content index components are adsorbed and intercepted, resulting in less effective active ingredients. The present invention changes the slag liquid separation method, does not pass through the slag, and directly extracts the liquid from the top, so that the effective ingredient content in the slag formula granules prepared later is significantly improved.
[0095] The specific liquid medicine separation method and the raw material ratio in the auxiliary material selected in the present invention can effectively obtain a higher 3,29-dibenzoyl trichosanthes trichosanthes content and content transfer rate, and the obtained Trichosanthes fruit particles have a better repose angle and stability.
[0096] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
Claims
1. A preparation method for improving the content of index components of Trichosanthes fruit paste powder, characterized in that: The preparation method for improving the content of index components of the trichosanthes seed paste powder is to take the trichosanthes seed slices and water and add them to an extraction tank, perform two cycles of extraction, extract the supernatant from the top of the extraction tank after each extraction, combine the supernatants extracted twice, and then concentrate, add the auxiliary material formed by mixing dextrin, maltodextrin and silicon dioxide to the obtained concentrated solution, stir evenly, and directly spray dry to obtain the trichosanthes seed paste powder.
2. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1, wherein: The weight ratio of dextrin, maltodextrin and silicon dioxide in the auxiliary materials is 1:1-4:0.28-0.
32.
3. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1 or 2, characterized in that: The weight ratio of the auxiliary materials added to the concentrated solution to the Trichosanthes fruit slices is 0.75-1.00:
10.
4. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1 or 2, characterized in that: The preparation method for increasing the content of index components of Trichosanthes fruit paste powder comprises the following steps: S1, add water to the extraction tank, heat it, put the Fructus Trichosanthis pieces into it, and perform the first cycle extraction. After the extraction is completed, extract the supernatant from the top of the extraction tank to obtain a medicine solution; S2, after the extraction of the medicinal liquid is completed, water is added to the remaining medicinal residue for the second time, and after heating, a second cycle extraction is performed. After the extraction is completed, the supernatant is extracted from the top of the extraction tank again to obtain the second extraction medicinal liquid; S3, combining the first extraction liquid and the second extraction liquid, and performing low-temperature vacuum concentration, and after the concentration is completed, a concentrated solution is obtained; S4, mixing dextrin, maltodextrin and silicon dioxide to obtain auxiliary materials; The concentrated solution is added with auxiliary materials, stirred and mixed evenly, and then directly spray-dried to obtain the Trichosanthes fruit paste powder.
5. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 4, characterized in that: In step S3, the temperature of low-temperature vacuum concentration is 60 to 70°C and the vacuum degree is -0.04 to -0.10 MPa.
6. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1, 2 or 5, characterized in that: The concentrated liquid has a concentrated density of 1.00 to 1.
04.
7. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1, 2 or 5, characterized in that: During the two extraction cycles, the amount of water used was 10 to 20 times the weight of the Trichosanthes fruit slices.
8. The method for preparing the method for improving the content of index components of the Fructus Trichosanthis paste powder according to claim 1, 2 or 5, characterized in that: The temperature of the two extraction cycles is 95-100° C., the time of the first extraction cycle is 0.7-1 h, and the time of the second extraction cycle is 0.5-1 h.
9. A method for preparing a granule for improving the content of index components of Fructus Trichosanthis, characterized in that: The method for preparing the granules with improved index component content of the seeds of Trichosanthes kirilowii formula comprises preparing the seeds of Trichosanthes kirilowii paste powder by the method for preparing the granules with improved index component content of the seeds of Trichosanthes kirilowii paste powder according to any one of claims 1 to 8, mixing the powder with auxiliary materials for granules, and preparing the seeds of Trichosanthes kirilowii formula granules by dry granulation.
10. The method for preparing the Fructus Trichosanthis Formula Granules for improving the content of index components according to claim 9, characterized in that: The auxiliary material for the granules is prepared by mixing dextrin and lactose in a weight ratio of 1:1.3-2.5; The weight ratio of the trichosanthes seed paste powder to the auxiliary materials for the granules is 1:0.06-0.08.