Traditional Chinese medicine composition for treating thoracic obstruction and preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating thoracic obstruction and a preparation method and application thereof. The traditional Chinese medicine composition for treating thoracic obstruction is prepared from the following raw materials in parts by weight: 8-12 parts of astragalus membranaceus, 3-7 parts of kudzu vine roots, 8-12 parts of peach kernels, 3-7 parts of trichosanthes kirilowii maxim and 3-7 parts of cape jasmine. The traditional Chinese medicine composition has the advantages that the prescription is determined according to reasons, the method follows the syndrome, the prescription is taken out according to the method, the basis is provided, the components are compatible, both symptoms and root causes are considered, and the curative effect is remarkable.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chest pain, and a preparation method and application thereof. Background Art

[0002] The chest pain referred to by traditional Chinese medicine, also known as "sudden heart pain" and "collapse heart pain", is caused by the retention of cold yin and phlegm in the chest, which makes the chest yang weak, or the heart qi insufficient, the agitation is weak, the qi and blood are blocked, and the heart is not nourished. The main manifestation is paroxysmal or persistent chest pain. Because the course of chest pain is long, the vital energy becomes weaker over time. The pathogenesis of chest pain is mainly qi deficiency leading to blood stasis. In other words, the fundamental cause of chest pain is qi deficiency, and blood stasis and phlegm are its pathological products.

[0003] Chest pain is similar to the symptoms of coronary artery atherosclerosis in Western medicine. It refers to a heart disease caused by blockage or narrowing of the blood vessel lumen due to coronary artery atherosclerosis, which in turn leads to myocardial hypoxia or necrosis. It is referred to as coronary heart disease or ischemic heart disease. Clinically, the main manifestations of this disease are paroxysmal chest tightness and chest pain in the left chest. In severe cases, it is accompanied by chest pain that spreads to the back and shortness of breath.

[0004] The existing treatment methods mainly include surgery and western medicine, but long-term use of western medicine has certain side effects, and surgery is not only traumatic but also expensive. Clinical studies have shown that Chinese medicine has significant effects on cardiovascular diseases, has unique advantages and rich experience, is economical and has few side effects. Summary of the invention

[0005] The object of the present invention is to provide a Chinese medicine composition for treating chest pain, a preparation method and an application thereof according to the deficiencies of the prior art. The present invention is a prescription based on the cause and treatment, a method based on the symptoms, a prescription based on the method, and a prescription based on evidence. Through the mutual compatibility of the components, the symptoms and the root cause are taken into consideration, and the curative effect is significant, providing a better product for clinically alleviating and curing patients with chest pain and heart pain.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] The first object of the present invention is to provide a Chinese medicine composition for treating chest pain.

[0008] The second object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition for treating chest pain.

[0009] The third object of the present invention is to provide the use of the above-mentioned Chinese medicine composition for treating chest pain.

[0010] To achieve the first purpose, the technical solution adopted by the present invention is:

[0011] The invention provides a traditional Chinese medicine composition for treating chest obstruction. The traditional Chinese medicine composition is prepared from astragalus, kudzu root, peach kernel, trichosanthes and gardenia.

[0012] Furthermore, the Chinese medicine composition for treating chest pain is prepared from the following raw materials in parts by weight: 8-12 parts of astragalus, 3-7 parts of kudzu root, 8-12 parts of peach kernel, 3-7 parts of trichosanthes and 3-7 parts of gardenia.

[0013] Furthermore, the Chinese medicine composition for treating chest pain is made from the following raw materials in parts by weight: 10 parts of astragalus, 5 parts of kudzu root, 10 parts of peach kernel, 5 parts of trichosanthes and 5 parts of gardenia.

[0014] Furthermore, the Chinese medicine composition for treating chest pain is made from the following raw materials in parts by weight: 8 parts of astragalus, 7 parts of kudzu root, 8 parts of peach kernel, 7 parts of trichosanthes and 3 parts of gardenia.

[0015] The Chinese medicine composition of the present invention also includes pharmaceutically acceptable excipients, which may include but are not limited to solvents, solubilizers, co-solvents, colorants, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, suspending agents, coating materials, anti-adhesive agents, integrities, plasticizers, etc.

[0016] The Chinese medicinal materials in the above-mentioned weight portions are taken to prepare the Chinese medicinal raw materials of the present invention, and conventional adjuvants are added according to conventional pharmacy methods to prepare various clinically acceptable dosage forms, which include but are not limited to tablets, capsules, oral liquids, lozenges, granules, granules, pills, drops, powders, pastes, pills, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, and patches. The tablets can be ordinary tablets, sugar-coated tablets, and film tablets, and the capsules can be hard capsules or soft capsules.

[0017] Furthermore, the dosage form of the Chinese medicine composition for treating chest pain is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or pastes.

[0018] To achieve the second purpose, the technical scheme adopted by the present invention is: the preparation method of the traditional Chinese medicine composition for treating chest pain of the present invention is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3h, the second time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3h, combining the decoctions, and concentrating under reduced pressure to an extract with a relative density of 1.05-1.15.

[0019] Furthermore, the preparation method of the present invention is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6 times the weight of the medicinal materials, boiling for 2 hours, the second time adding water is 8 times the weight of the medicinal materials, boiling for 3 hours, combining the decoctions, and concentrating under reduced pressure to an extract with a relative density of 1.10.

[0020] To achieve the third purpose, the technical solution adopted by the present invention is: the present invention provides the use of the traditional Chinese medicine composition for treating chest pain in preparing a medicine for preventing or treating chest pain.

[0021] The present invention's solution:

[0022] Astragalus: sweet in nature and slightly warm in flavor, it enters the lung and spleen meridians, replenishes qi and raises yang, consolidates the exterior and stops sweating, promotes diuresis and reduces edema, promotes the production of body fluids and nourishes blood, relieves stagnation and arthritis, removes toxins and discharges pus, and heals sores and promotes tissue regeneration. It is used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, long-term diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, qi deficiency and edema, internal heat and thirst, blood deficiency and sallow complexion, hemiplegia, pain and numbness of arthritis, carbuncles that are difficult to heal, and long-term sores that do not heal.

[0023] Pueraria root: sweet, spicy, and cool in taste, it enters the spleen, stomach, and lung meridians, relieves muscles and reduces fever, promotes the production of body fluids and quenches thirst, raises yang and stops diarrhea, promotes blood circulation and activates collaterals, and detoxifies alcohol; it is used for exogenous fever and headache, stiff neck and back pain, thirst, diabetes, measles that does not break out, heat dysentery, diarrhea, dizziness and headache, hemiplegia caused by stroke, chest pain and heart pain, and alcohol toxicity.

[0024] Peach kernel: bitter, sweet, and neutral in nature, it enters the heart, liver, and large intestine meridians, promotes blood circulation and removes blood stasis, moistens the intestines and promotes bowel movements, and is used to treat dysmenorrhea, blood stasis and amenorrhea, abdominal pain due to postpartum blood stasis, masses, bruises, pain due to blood stasis, lung abscess, intestinal abscess, and constipation due to dry intestines.

[0025] Trichosanthes: sweet, slightly bitter in taste, cold in nature, enters the lung, stomach, and large intestine meridians, clears away heat and resolves phlegm, relieves chest congestion, moistens the intestines and promotes bowel movements; treats cough and asthma due to phlegm-heat, chest pain, chest congestion, lung abscess, intestinal abscess, breast abscess, and constipation due to dry intestines.

[0026] Gardenia: bitter in taste, cold in nature, enters the heart, lung, and triple burner meridians, clears away heat and relieves restlessness, clears heat and removes dampness, cools blood and detoxifies; it treats restlessness due to febrile disease, jaundice due to damp heat, painful and astringent blood in the stranguria, vomiting and bleeding due to blood heat, red and swollen painful eyes, and fire poison sores.

[0027] In the prescription of the present invention, Gardenia is the main drug, and it is aimed at the toxic evil in the process of chest obstruction and true heart pain, and it is the main drug for purging fire and clearing heat, cooling blood and detoxifying; Trichosanthes is wide-chested, promoting yang, resolving phlegm and dispersing knots, and peach kernel enters the heart to promote blood circulation and remove blood stasis, and helps the main drug as the minister; Astragalus replenishes qi to treat its root, and qi helps blood circulation and removes blood stasis, and Pueraria root ascends the clearness to help the power of Astragalus, and also leads the product of warming the kidney to the heart, all of which are adjuvants; Gardenia is bitter and cold, and it enters the heart, lung, and triple burner meridians, and peach kernel is bitter, sweet, and flat, and it enters the heart, liver, and large intestine meridians, all of which have the effect of leading the meridians and reporting the messenger. The prescription of the present invention examines the cause and discusses the treatment, the method is established according to the evidence, the prescription is derived from the method, and the prescription is based on evidence. Through the mutual compatibility of each component, both the symptoms and the root are taken into account, and the curative effect is remarkable.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] After treatment with the Chinese medicine composition of the present invention, the left ventricular ejection fraction can be significantly improved, and the myocardial infarction caused by local ischemia of the heart can be effectively reduced, the heart function can be significantly improved, and the development process of chronic heart failure can be successfully intervened.

[0030] The Chinese medicine composition of the present invention can significantly reduce the frequency and degree of angina pectoris attacks in patients with chest obstruction, change the ST-T segment status of the electrocardiogram, improve the cardiac ischemia condition, and has a significant protective effect on the heart. The clinical effect is significant and superior to similar clinical drugs, and provides a better product for clinically alleviating and curing patients with chest obstruction and angina pain. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 Comparison of ejection fraction among groups

[0032] Compared with the normal control group, # P<0.05, ## P<0.01; compared with the model control group, * P<0.05, ** P<0.01; compared with Example 1 group, & P<0.05, && P<0.01.

[0033] Figure 2 Comparison of infarct size among groups

[0034] Compared with the normal control group, # P<0.05, ## P<0.01; compared with the model control group, * P<0.05, ** P<0.01; compared with the Example 1 group, & P<0.05, && P<0.01.

[0035] Figure 3 To compare the clinical efficacy of each group. DETAILED DESCRIPTION

[0036] The embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention.

[0037] Example 1

[0038] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 10g of astragalus, 5g of kudzu root, 10g of peach kernel, 5g of trichosanthes and 5g of gardenia.

[0039] After combining the medicinal materials, add water and boil twice. The first time, add water that is 6 times the weight of the medicinal materials and boil for 2 hours. The second time, add water that is 8 times the weight of the medicinal materials and boil for 3 hours. Combine the decoctions and concentrate under reduced pressure to an extract with a relative density of 1.10.

[0040] Example 2

[0041] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 8g of astragalus, 7g of kudzu root, 8g of peach kernel, 7g of trichosanthes and 3g of gardenia.

[0042] After combining the medicinal materials, add water and boil twice. The first time, add water that is 8 times the weight of the medicinal materials and boil for 3 hours. The second time, add water that is 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions and concentrate under reduced pressure to an extract with a relative density of 1.15.

[0043] Example 3

[0044] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 12g of astragalus, 3g of kudzu root, 12g of peach kernel, 3g of trichosanthes and 7g of gardenia.

[0045] After combining the medicinal materials, add water and boil twice. The first time, add water that is 7 times the weight of the medicinal materials and boil for 2.5 hours. The second time, add water that is 8 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions and concentrate under reduced pressure to an extract with a relative density of 1.05.

[0046] Example 4

[0047] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 10g of astragalus, 7g of kudzu root, 8g of peach kernel, 5g of trichosanthes and 7g of gardenia.

[0048] After combining the medicinal materials, add water and boil twice. The first time, add water that is 8 times the weight of the medicinal materials and boil for 3 hours. The second time, add water that is 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions and concentrate under reduced pressure to an extract with a relative density of 1.10.

[0049] Example 5

[0050] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 12g of astragalus, 5g of kudzu root, 10g of peach kernel, 7g of trichosanthes and 3g of gardenia.

[0051] After combining the medicinal materials, add water and boil twice. The first time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. The second time, add water that is 6 times the weight of the medicinal materials and boil for 2.5 hours. Combine the decoctions and concentrate under reduced pressure to an extract with a relative density of 1.15.

[0052] Comparative Example 1

[0053] CN106668386A A Chinese medicine preparation for treating acute coronary syndrome caused by spleen deficiency with phlegm, blood stasis and toxins, in Example 1, comprises 10g of Astragalus, 6g of Pinellia, 5g of Pueraria, 10g of Semen Persicae, 5g of Trichosanthis, 5g of Gardenia, and 10g of Forsythia. The decoction is prepared according to the preparation method of Example 1 of the patent.

[0054] Comparative Example 2

[0055] A traditional Chinese medicine composition for preventing or treating chest obstruction is prepared from the following raw materials: 10g of astragalus, 5g of kudzu root, 15g of peach kernel and 5g of gardenia.

[0056] The preparation method is the same as that of Example 1.

[0057] Comparative Example 3

[0058] A traditional Chinese medicine composition for preventing or treating chest pain is prepared from the following raw materials: 10g of Codonopsis pilosula, 5g of Pueraria root, 10g of peach kernel, 5g of Trichosanthes kirilowii and 5g of Lophatherum gracile.

[0059] The preparation method is the same as that of Example 1.

[0060] Efficacy Example Therapeutic effect of the Chinese medicine composition of the present invention on rats with chronic heart failure

[0061] 1. Experimental Methods

[0062] 56 clean male SD rats, weighing 220±20g, were given free access to water and food, and the room temperature was maintained at 20-25℃. After 7 days of quarantine, 8 rats were randomly selected as the sham operation group, and the rest were the operation group. Anesthesia was performed by intraperitoneal injection of 8% chloral hydrate at 5ml / kg. The neck and left chest of the rats were shaved and disinfected with iodine tincture. The skin of the neck was opened, blunt separation was performed, the trachea was exposed, the tracheal rings were cut, and the endotracheal tube was placed. The other end was connected to the ventilator, and the respiratory rate was adjusted to 70 times per minute, the tidal volume was 10-12ml, and the respiratory ratio was 1:1. The skin of the chest was opened, blunt separation was performed between the 2nd and 3rd ribs, the ribs were propped open with stainless steel, the chest cavity was exposed, the thymus was separated, the pericardium was cut, and the heart was fished out with a homemade steel ring. A 6-0 suture needle with thread was inserted between the lower edge of the left atrial appendage and the pulmonary artery cone, with a depth of about 0.1cm and a width of 0.1-02cm. After the heart was reset and the rat's heartbeat returned to normal, the knot was tied, the chest cavity was closed, and the chest cavity was gently pressed to exhaust air, and sutured layer by layer. The endotracheal tube was removed and the rat's spontaneous breathing was restored. The heart of the sham operation group did not need to be threaded and ligated, and the rest of the operations were the same.

[0063] After 4 weeks of cage culture, the left ventricular ejection fraction was detected by Doppler ultrasound. The model was successfully established when the reduction was 30% or more compared with that before modeling. The surgical group was randomly divided into a model control group, Example 1 group, and 2 group, and Comparative Example 1 group, 2 group, and 3 group, with 8 mice in each group. Each group was gavaged with the corresponding decoction at a dose of 5.6 g / kg, and the sham operation group and the model control group were gavaged with an equal volume of normal saline. The drug was administered once a day for 4 weeks.

[0064] 2. Sample collection and indicator testing

[0065] Four weeks after administration, the left ventricular ejection fraction was detected using Doppler ultrasound, and the heart was removed by anesthesia and frozen in a freezer for 30 minutes. The heart was sliced ​​transversely perpendicular to the long axis and incubated with 1% 2,3,5-triphenyltetrazolium chloride (TTC) at 37°C for 20 minutes. The infarct area ratio was calculated using Image J after taking pictures.

[0066] Infarct area ratio = infarct area / total left ventricular area × 100%.

[0067] 3. Statistical methods

[0068] Graphpad Prism 9.0 software was used for data processing, and the measured data were expressed as mean ± standard deviation. One-way analysis of variance was used for comparison among multiple groups, and SNK-q was used for pairwise comparison among groups. The difference was considered statistically significant when P < 0.05.

[0069] 4. Experimental Results

[0070] 4.1 Effects on left ventricular ejection fraction in rats

[0071] Compared with the sham operation group, the left ventricular ejection fraction of the rats in the model control group was significantly reduced, indicating that the cardiac function of the rats was significantly damaged after modeling and was in the process of chronic heart failure. Compared with the model control group, the left ventricular ejection fraction of Example 1, Example 2, Comparative Example 1, and Comparative Example 2 were all significantly increased. The effect of improving the left ventricular ejection fraction in Example 1 was the best, and it had a significant protective effect on the cardiac function of rats. Results are shown in Figure 1 .

[0072] 4.2 Effects on myocardial infarction in rats

[0073] Compared with the sham operation group, the myocardial infarction area of ​​the rats in the model control group increased significantly, indicating that the myocardium of the rats after modeling was significantly necrotized and the heart function was seriously damaged. Compared with the model control group, the myocardial infarction area of ​​the Example 1 group, the Example 2 group, the Comparative Example 1 group, and the Comparative Example 2 group were all significantly reduced. The effect of improving myocardial infarction in the Example 1 group was the best, and it played a significant protective role on the rat heart. The results are shown in Figure 2 .

[0074] Compared with the sham operation group, the left ventricular ejection fraction and myocardial infarction area of ​​the model control group rats changed significantly and lasted for 8 weeks, indicating that the rats' cardiac function was significantly damaged and in the process of chronic heart failure. After 4 weeks of treatment with the Chinese medicine composition Example 1, the left ventricular ejection fraction of the rats can be significantly improved, and the myocardial infarction caused by cardiac ischemia is effectively reduced, the cardiac function is significantly improved, and the development process of chronic heart failure can be successfully intervened, providing an effective product for alleviating and curing chronic heart failure.

[0075] Clinical example: Observation on the clinical efficacy of the Chinese medicine composition of the present invention on patients with chest pain and heart pain

[0076] 1. General Information

[0077] 60 patients with chest pain and angina pectoris were selected from our hospital. They met the diagnostic criteria for angina pectoris of coronary heart disease and chest pain and angina pectoris, had a history of angina pectoris, and had elevation of the ST-T segment of the electrocardiogram indicating ischemic changes. Patients with organic diseases of major organs, underlying diseases, and acute myocardial infarction were excluded. Patients who met the above requirements were randomly divided into a control group and a treatment group, with 30 people in each group. Among them, there were 18 males and 12 females in the control group, 8 cases of spontaneous angina pectoris, 19 cases of exertional angina pectoris, and 3 cases of post-myocardial infarction angina pectoris, with an average age of (57.1±11.7) years old; there were 20 males and 10 females in the treatment group, 10 cases of spontaneous angina pectoris, 18 cases of exertional angina pectoris, and 2 cases of post-myocardial infarction angina pectoris, with an average age of (55.6±13.2) years old.

[0078] There was no statistical difference in the general information of patients in each group (P>0.05), and they were comparable.

[0079] 2. Treatment Methods

[0080] Patients in the control group took compound danshen tablets orally 3 times a day.

[0081] The patients in the treatment group took the product of Example 1 orally, once in the morning, noon and evening, for a course of 4 weeks.

[0082] 3. Observation indicators

[0083] Before and after treatment, the scores were compared, and the number of angina attacks and the degree of chest pain were scored as mild, moderate and severe, and the changes in the electrocardiogram before and after treatment were recorded. The number of angina attacks per day was more than 10 times as severe, 5-10 times as moderate, and less than 5 times as mild. Cure criteria: chest pain symptoms basically disappeared, and the ST-T segment of the electrocardiogram returned to normal; markedly effective criteria: the number and degree of chest pain were significantly relieved, the ST-T segment of the electrocardiogram was significantly improved, and the inverted T wave became upright; effective criteria: the number and degree of chest pain were improved, and the inverted T wave became shallower; invalid criteria: chest pain symptoms did not improve, and there was no change in the electrocardiogram.

[0084] Total effective rate = (number of clinically cured + markedly effective + effective) cases / total number of cases × 100%.

[0085] 4. Statistical methods

[0086] SPSS 19.0 software was used for data processing. The data of each group were subjected to normal distribution test and variance homogeneity test, and the inter-group comparison was performed with one-way analysis of variance, with P < 0.05 as statistically significant.

[0087] 5. Comparison of clinical efficacy

[0088] Table 1 Comparison of clinical efficacy

[0089] Group Number of cases / case Total effective rate / % Control group 30 74.1 Treatment Group 30 90.3

[0090] Depend on Figure 3 As shown in Table 1, the total effective rate of the control group was 74.1%, and the total effective rate of the treatment group was 90.3%. The clinical efficacy of the treatment group in improving patients with chest pain and angina was significantly better than that of the control group.

[0091] The Chinese medicine composition of the present invention can significantly reduce the frequency and degree of angina pectoris attacks in patients with chest pain, change the ST-T segment state of the electrocardiogram, improve the condition of cardiac ischemia, and has a significant protective effect on the heart. The clinical effect is significant and better than similar clinical drugs, providing a better product for clinically alleviating and curing patients with chest pain.

[0092] The present invention has been described in detail above by general description and specific embodiments, but it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made on the basis of not departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine composition for treating chest pain, characterized in that: The Chinese medicine composition for treating chest pain is prepared from the following raw materials in parts by weight: 8-12 parts of astragalus, 3-7 parts of kudzu root, 8-12 parts of peach kernel, 3-7 parts of trichosanthes and 3-7 parts of gardenia.

2. The Chinese medicine composition for treating chest pain according to claim 1, characterized in that: The Chinese medicine composition for treating chest pain is prepared from the following raw materials in parts by weight: 10 parts of astragalus, 5 parts of kudzu root, 10 parts of peach kernel, 5 parts of trichosanthes and 5 parts of gardenia.

3. The Chinese medicine composition for treating chest pain according to claim 1, characterized in that: The Chinese medicine composition for treating chest pain is prepared from the following raw materials in parts by weight: 8 parts of astragalus, 7 parts of kudzu root, 8 parts of peach kernel, 7 parts of trichosanthes and 3 parts of gardenia.

4. The Chinese medicine composition for treating chest pain according to any one of claims 1 to 3, characterized in that: The traditional Chinese medicine composition for treating chest pain also includes pharmaceutically acceptable excipients.

5. The Chinese medicine composition for treating chest pain according to claim 4, characterized in that: The traditional Chinese medicine composition for treating chest pain is a clinically acceptable dosage form.

6. The Chinese medicine composition for treating chest pain according to claim 5, characterized in that: The dosage form of the Chinese medicine composition for treating chest pain is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or pastes.

7. The Chinese medicine composition for treating chest pain according to any one of claims 1 to 3, characterized in that: The preparation method of the Chinese medicine composition for treating chest pain is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3 hours, the second time adding water is 6-8 times the weight of the medicinal materials, boiling for 2-3 hours, combining the decoctions, and concentrating under reduced pressure to an extract with a relative density of 1.05-1.

15.

8. The Chinese medicine composition for treating chest pain according to any one of claims 1 to 3, characterized in that: The preparation method of the Chinese medicine composition for treating chest pain is as follows: after combining the medicinal materials, add water and boil twice, the first time adding water is 6 times the weight of the medicinal materials, boiling for 2 hours, the second time adding water is 8 times the weight of the medicinal materials, boiling for 3 hours, combining the decoctions, and concentrating under reduced pressure to an extract with a relative density of 1.

10.

9. Use of the Chinese medicine composition for treating chest pain according to any one of claims 1 to 3 in preparing a medicine for preventing or treating chest pain.

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