Method for manipulating spherical particles in tube by using acoustic radiation force

Abstract

The invention discloses a method for manipulating spherical particles in a tube, which can realize accurate regulation and control of acoustic radiation force based on the acoustic radiation force generated by an acoustic nonlinear effect, so that the spherical particles in the tubes with different sizes and materials in different specific environments are subjected to non-contact acoustic radiation force, thereby realizing manipulation of the spherical particles. According to the method, acoustic radiation force can be applied to the spherical particles in the tube under different conditions, so that the spherical particles are manipulated, and a solution is provided for medical and industrial application.

Description

Technical Field

[0001] The present invention relates to the field of acoustic manipulation technology, and mainly to a method for manipulating spherical particles in a tube by designing a method using nonlinear acoustic principles to achieve precise regulation of acoustic radiation force, so that spherical particles of different sizes and materials in different specific environments are subjected to non-contact acoustic radiation force, thereby achieving manipulation thereof. Background Art

[0002] In the fields of life sciences and industry, pipes are common boundaries. The present invention proposes a method for manipulating spherical particles in a tube based on acoustic radiation force. Acoustic radiation force is an effective way to achieve particle manipulation. This method can achieve non-contact manipulation, has good bioadaptability, lower thermal effects and stronger penetration. The proposal of this scheme has opened up a new non-contact method for the manipulation of spherical particles in tubes. In medicine, this method can achieve non-invasive manipulation, greatly reduce the pain of patients, and has important application prospects in disease treatment. In the industrial field, this method can achieve non-contact manipulation of objects in tubes, and also has important application value. Summary of the invention

[0003] Purpose of the invention: To design a method based on the principle of acoustic radiation force so that spherical particles in a tube are subjected to the acoustic radiation force and thus can be precisely manipulated.

[0004] Technical solution: A method for applying acoustic radiation force to a structure by utilizing acoustic nonlinear effects, the method comprising a signal generator capable of regulating signal parameters, a power amplifier for amplifying the signal, and an ultrasonic transducer for converting electrical signals into ultrasonic signals as basic elements.

[0005] Based on the relevant theories of acoustic radiation force, the signal type and power parameters can be adjusted by design to achieve precise control and specific optimization of the acoustic radiation force exerted on spherical particles in tubes of different sizes and materials in different specific environments.

[0006] According to the principle of nonlinear acoustics, for structures in an acoustic field, when the wavelength of the sound wave is close to the scale of the structure, the structure will be subject to a more obvious acoustic radiation force. The theory of acoustic radiation force can be used to modulate the parameters of the emission signal, thereby achieving precise control and specific optimization of the acoustic radiation force on spherical particles in tubes of different sizes and materials in different specific environments, so that the spherical particles in the tube are non-contact driven by the acoustic radiation force and then manipulated, which is the basic principle of the present invention.

[0007] Beneficial effects:

[0008] Compared with the existing technology, it has the following characteristics: by utilizing the nonlinear effect of acoustics, non-contact manipulation of structures in the sound field can be achieved. Compared with the existing contact manipulation method, non-contact manipulation can be achieved, which is non-invasive and non-destructive, and provides a new means of manipulation for fields such as medicine and industry.

[0009] By designing the emission signal parameters, it is possible to achieve precise control and specific optimization of the acoustic radiation force exerted on spherical particles in tubes of different sizes and materials in different specific environments. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] Figure 1 Method and experimental principle of applying acoustic radiation force to spherical particles in a tube.

[0011] Figure 2 The acoustic radiation force exerted by the spherical particle manipulation method in the tube on spherical particles of different radii in the tube obtained theoretically and experimentally. The experimental values ​​are expressed as mean ± standard deviation.

[0012] Figure 3 The acoustic radiation force exerted by the theoretical and experimental methods for manipulating spherical particles in tubes with different diameters. The experimental values ​​are expressed as mean ± standard deviation.

[0013] Figure 4 The acoustic field distribution in the tube when the spherical particle manipulation method in the tube obtained by finite element simulation applies acoustic radiation force to the spherical particles in the tube. DETAILED DESCRIPTION

[0014] The method and experimental principle diagram of the present invention for applying acoustic radiation force to spherical particles in a tube are shown in FIG. Figure 1 shown. Figure 1 The present invention provides a method and an experimental schematic diagram for applying acoustic radiation force to spherical particles in a tube. The experimental system for manipulating spherical particles in a tube can be composed of a signal generator for regulating signal parameters, a power amplifier for amplifying signals, and an ultrasonic transducer for converting electrical signals into ultrasonic signals as basic elements. The signal generator emits a signal of a specified frequency spectrum based on modulation, which is amplified by the power amplifier and input into the ultrasonic transducer. The ultrasonic transducer converts the electrical signal into an ultrasonic signal and emits sound waves into the pipe, thereby constructing a sound field near the spherical particles in the tube. Based on the acoustic nonlinear effect, the spherical particles in the tube will be driven by the acoustic radiation force, thereby generating movement to promote their discharge.

[0015] The acoustic radiation force on the spherical particles in the tube can be calculated by the following formula:

[0016]

[0017] Here σ is the stress tensor, s 0is the surface of the spherical particle in the tube being manipulated, and < > is the time average. Since the fluid environment in which the spherical particle in the tube is located is generally a viscous fluid, the viscosity of the medium needs to be considered, and the stress tensor can be expressed as:

[0018]

[0019]

[0020]

[0021] Where E is the unit vector, λ′ is the expansion viscosity coefficient, μ′ is the dynamic viscosity coefficient, v is the particle motion velocity of the medium at that location, ρ 0 is the density of the ambient medium, i.e. the viscous fluid in the tube, c 0 is the sound velocity of the ambient medium, i.e. the viscous fluid in the tube.

[0022] In order to verify the effectiveness and feasibility of the invention, we conducted theoretical calculations and experiments. In the experiment, we first used the spherical particle manipulation method in the tube to apply the acoustic radiation force to the spherical particles in the tube with different radii. The incident sound wave frequency used was 1MHz, the angle between the incident sound beam and the pipe was 45 degrees, the outer diameter of the pipe was 4.00mm, the thickness was 0.50mm, the radius of the spherical particles in the tube was distributed from 2.00mm to 3.49mm, and the acoustic radiation force on the spherical particles in the tube was as follows: Figure 2 shown.

[0023] The experiment also used the spherical particle manipulation method to apply acoustic radiation force to spherical particles in tubes with different diameters. The outer diameter of the pipe used was 3.00mm-5.00mm, the radius of the spherical particle in the tube was 2.49mm, and the other parameters were the same as the previous acoustic radiation force applied to spherical particles in tubes with different radii. The acoustic radiation force on the spherical particles in the tube is as follows: Figure 3 shown.

[0024] Figure 2 The acoustic radiation force exerted by the spherical particle manipulation method in the tube on spherical particles of different radii in the tube obtained theoretically and experimentally. The experimental values ​​are expressed as mean ± standard deviation.

[0025] Figure 3 The acoustic radiation force exerted by the theoretical and experimental methods for manipulating spherical particles in tubes with different diameters. The experimental values ​​are expressed as mean ± standard deviation.

[0026] In order to further illustrate the acoustic radiation force, the acoustic field distribution in the tube when the spherical particle manipulation method in the tube applies the acoustic radiation force to the spherical particles in the tube is drawn based on the finite element simulation, as shown in Figure 4 shown.

[0027] Figure 4The acoustic field distribution in the tube when the spherical particle manipulation method in the tube obtained by finite element simulation applies acoustic radiation force to the spherical particles in the tube.

[0028] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A method for manipulating spherical particles in a tube using acoustic radiation force, characterized in that: The working principle of the method is based on acoustic radiation force, which realizes the difference in force on both sides of the spherical particles in the tube, thereby realizing the manipulation of the spherical particles.

2. The method of manipulating spherical particles in a tube using acoustic radiation force according to claim 1, characterized in that: The method is composed of a signal generator capable of adjusting signal parameters, a power amplifier for amplifying the signal, and an ultrasonic transducer for converting the electrical signal into an ultrasonic signal as basic elements.

3. The method of manipulating spherical particles in a tube using acoustic radiation force according to claim 1, characterized in that: Based on the acoustic nonlinear effect, the spherical particles in the tube are subjected to the acoustic radiation force in a non-contact manner.

4. The method of manipulating spherical particles in a tube using acoustic radiation force according to claim 1, characterized in that: By adjusting the signal type and power parameters, the sound field parameters can be changed, thereby changing the sound radiation force obtained by the spherical particles in the tube.

5. The method of manipulating spherical particles in a tube using acoustic radiation force according to claim 1, characterized in that: By adjusting the signal type and power parameters, precise control and specific optimization of the acoustic radiation force exerted on spherical particles in tubes of different sizes and materials in different specific environments can be achieved.

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