Heart valve prosthesis fixed through ventricular septum

Abstract

The invention relates to the field of medical instruments, in particular to a heart valve prosthesis fixed through ventricular septa.The heart valve prosthesis comprises a valve support and a fixing device, the valve support comprises a valve sewing section and an artificial valve, the artificial valve is fixedly connected to the valve sewing section, and the fixing device comprises a fixing supporting section and a fixing piece; one end of the fixed supporting section is connected to the near-end portion of the valve sewing section, and the other end of the fixed supporting section is connected to the ventricular septum of the patient through a fixing piece to support the heart valve prosthesis and limit axial movement of the heart valve prosthesis.

Description

Technical Field

[0001] The invention belongs to the field of medical devices, and in particular relates to a heart valve prosthesis fixed through a ventricular septum. Background Art

[0002] Traditional treatments for mitral and tricuspid valve diseases include medications for mild to severe regurgitation and surgical procedures with corresponding surgical indications. Among them, surgical procedures also include valve replacement and valve repair. Among surgical procedures, typical open-chest and open-heart surgeries are too invasive and require extracorporeal circulation, with a high incidence of complications and infection risks. Many patients cannot tolerate the huge surgical risks and can only wait for death.

[0003] With the report of the first aortic valve interventional replacement, many companies have done a lot of work in interventional aortic valve technology, and the technology is becoming more mature. However, there is still a large gap in the industry in the interventional treatment of the atrioventricular valve. Although a few products for the interventional treatment of the atrioventricular valve have been used in transcatheter interventional valvuloplasty and repair, there are no mature products available internationally in the field of transcatheter interventional valve replacement.

[0004] Current clinical results show that there is no ideal product for interventional atrioventricular valve replacement. The main reason is that both the mitral valve and the tricuspid valve have special physiological structures, and there is a complex physiological environment under the valve ring, which makes it very difficult to accurately position and fix the product. The problems of existing technologies are summarized as follows: (1) Current anchoring technology mostly relies on the support of the stent on the atrioventricular valve ring. Doctors often choose valve specifications that are larger than the patient's atrioventricular valve ring to cater to the contour of the mitral valve tissue. Not only will the huge stent itself affect the outflow tract, but it is also easy to cause compression to the surrounding tissues, further blocking the blood flow in the left ventricular outflow tract; (2) In current technologies, the stent part located in the atrium is mostly in the form of a grid, and its huge supporting force is easy to cause compression to the heart tissue; (3) For mitral valve replacement, the stent specifications are too large, and the anterior leaflet of the mitral valve is easily pushed into the left ventricular outflow tract. In order to fix the mitral valve, the stent specifications are too large. The clamping leaflet design introduced by the cusp valve anterior leaflet makes the release step very complicated and is affected by the degree of leaflet calcification, which affects the success rate of the operation; (4) Under the current non-radial force support fixation method of the ventricular septum, the distal end of the fixed support segment and the contact part of the patient's ventricular septum and the ventricular septum plane are not in contact, resulting in failure of the fixing device to anchor; forced anchoring has excessive stress, which causes damage to the ventricular septum muscle tissue and the fixing device to be pulled out and fall off; (5) Due to the presence of the native leaflet, the adaptive stent graft is not tightly fitted, and the artificial valve replaced by the atrioventricular valve will have paravalvular leakage at the junction of the native leaflet. (6) Due to the differences in the heart size and structure of different individuals, due to the differences in adults, children, and Eastern and Western races, in order to achieve ventricular septum fixation, a very large European-sized fixed support segment is required, which has high manufacturing and management costs.

[0005] In summary, although the above-described technologies have certain effects on atrioventricular valve replacement, they still have shortcomings. In the field of surgery for treating valvular diseases, a new heart valve prosthesis is urgently needed to solve the above problems. Summary of the invention

[0006] This application is proposed in view of the above and other more concepts.

[0007] The purpose of the present invention is to overcome the limitations of the prior art and to propose a heart valve prosthesis fixed through the ventricular septum for patients who need interventional valve replacement due to mitral or tricuspid regurgitation or stenosis. The present invention solves the problem caused by the need to radially expand the patient's own valve ring in the existing anchoring technology. On the basis of ensuring the anchoring effect of the implanted valve, the impact of the stent on the outflow tract after release can be reduced to avoid pulling on the valve ring of the native valve.

[0008] The objective of the present invention is achieved through the following technical solutions: A heart valve prosthesis fixed through a ventricular septum comprises a valve support and a fixing device, wherein the valve support comprises a valve sewing section and an artificial valve, wherein the artificial valve is fixedly connected to the valve sewing section, and the fixing device comprises a fixed support section and a fixing piece, wherein one end of the fixed support section is connected to the proximal end of the valve sewing section, and the other end of the fixed support section is connected to the patient's ventricular septum through the fixing piece to support the heart valve prosthesis and limit the axial movement of the heart valve prosthesis.

[0009] The purpose of the present invention can be further achieved by the following technical solutions: Preferably, a curved section is provided on the fixed support section, so that the proximal end portion of the fixed support section can fit the patient's interventricular septum.

[0010] More preferably, the portion of the fixed support segment in contact with the patient's ventricular septum is a straight segment.

[0011] Preferably, the fixed support segment is made of one or more rods / wires, one end of the one or more rods / wires are respectively connected to the valve sewing segment, and the other end of the one or more rods / wires is provided with a portion cooperating with a fixing device, and is connected to the patient's ventricular septum through the fixing device.

[0012] Preferably, on the circumferential arc where the outer edge of the valve sewing segment is located, the maximum arc length formed by the connection points of the multiple rods or wires and the valve sewing segment is greater than or equal to one quarter of the circumference of the valve sewing segment.

[0013] Preferably, the fixed support section is provided with a structure that facilitates torsional deformation; Preferably, the structure that facilitates torsional deformation is a curved concave structure.

[0014] Preferably, the fixed support section is provided with a telescopic structure for facilitating length adjustment.

[0015] Preferably, the fixed support segment is formed by extending a skeleton at a proximal end of the valve sewing segment.

[0016] Preferably, the heart valve prosthesis further comprises an adaptive stent graft, which is connected to the valve sewing section, and in a free state, the adaptive stent graft is located in the patient's atrium. The distal end of the adaptive stent graft that is in contact with and fixedly connected to the valve stent is circular, the middle part of the adaptive stent graft is D-shaped, and the proximal end of the adaptive stent graft that contacts the atrial tissue is elliptical or quasi-elliptical; the self-expanding stent of the adaptive stent graft is integrally woven from silk material, and the coating on the self-expanding stent is a polymer flexible material, such as a PTFE film, a polyester film, etc.

[0017] Preferably, the heart valve prosthesis further comprises a leaflet lifting and blocking device, one end of which is fixed to the valve stent, and the other end of which is arranged on the outside of the valve stent and / or the adaptive coated stent.

[0018] Preferably, the leaflet lifting and blocking device is disposed at a position corresponding to the junction of the native leaflets.

[0019] Preferably, the fixing member is an anchoring needle, and a limiting member is provided at the tail of the anchoring needle.

[0020] Preferably, in a cross section perpendicular to the central axis of the artificial valve, the cross-sectional area of ​​the valve sewing section is smaller than the cross-sectional area of ​​the patient's native valve annulus, so that the valve sewing section will not radially expand the patient's native valve annulus.

[0021] Preferably, in a free state, the cross-sectional area of ​​the adaptive coated stent is larger than the cross-sectional area of ​​the patient's own valve annulus, and the adaptive coated stent can conform to the uneven contour of the atrial cavity wall or the patient's own valve annulus without restricting the contractile function of the atrium.

[0022] Preferably, in a cross section perpendicular to the central axis of the artificial valve, the center of the valve sewing segment does not coincide with the center of the adaptive stent graft.

[0023] Another object of the present invention is achieved through the following technical solutions: A method for delivering and releasing the heart valve prosthesis fixed through the ventricular septum comprises the following steps: a. Inserting the delivery catheter loaded with the heart valve prosthesis into the atrioventricular valve annulus; b. operating the delivery catheter to release the fixation device; c. operating the delivery catheter to release the valve sewing segment; d. operating the delivery catheter so that the fixing member is inserted into the patient's ventricular septum; e. withdrawing the delivery catheter from the human body.

[0024] Preferably, the following steps are included between step c and step d: c1. operating the delivery catheter to partially release the valve sewing segment so that the valve sewing segment is not completely separated from the delivery catheter; c2. operating the delivery catheter to release the adaptive stent graft and use the adaptive stent graft for positioning; c3. Operate the delivery catheter to completely release the valve sewing segment.

[0025] Compared with the prior art, the advantages of the present invention are: 1. Different from the design of most products in the prior art that use stents to support the valve ring, the fixed support segment in the present invention is fixed to the patient's ventricular septum through the fixing member. Such an anchoring method enables the stent to obtain sufficient anchoring force without radially expanding the patient's own valve ring.

[0026] 2. Since radial support of the valve stent is not adopted, the projected area of ​​the valve sewing section is smaller than the projected area of ​​the patient's own valve ring on the cross section perpendicular to the central axis of the artificial valve, so that the valve sewing section will not radially expand the patient's own valve ring; in order to make the fixed support section connected to the valve sewing section fit with the patient's ventricular septum, a curved section is provided on the fixed support section, so that the proximal part of the fixed support section can fit with the patient's ventricular septum, and the distal end of the fixed support section that contacts the patient's ventricular septum is a straight section. Such a design can maximize the contact area between the fixed support section and the patient's ventricular septum and enhance the anchoring effect.

[0027] 3. In the present invention, on the circumferential arc where the outer edge of the valve sewing segment is located, the maximum arc length formed by the connection points of the multiple rods and the valve sewing segment is greater than or equal to one-fourth of the circumference of the valve sewing segment. The advantage of such a design is to ensure that the fulcrum of the fixed support segment on the valve sewing segment can provide sufficient supporting strength and rigidity to avoid tilting of the valve sewing segment.

[0028] 4. In the actual operation, after the valve stent is released, due to the great difference in human heart structure, the distal end of the fixed support segment and the contact part of the patient's ventricular septum are often not in line with the plane of the ventricular septum. If the fixed support segment is fixed directly with a fixing device, it may be difficult to fix the fixing device to the ventricular septum, resulting in fixation failure; even if the distal end of the fixed support segment and the contact part of the patient's ventricular septum are forcibly attached to the ventricular septum and fixed; what's more, since the fixed support segment adopts: the maximum arc length formed by the connection points of the multiple rods or wires of the fixed support end and the valve sewing segment is greater than or equal to the The setting of one-fourth of the circumference of the valve sewing section causes the rigidity of the fixed support section to be too large. If the distal end of the fixed support section is forcibly fixed to the patient's ventricular septum by a fixing piece, in this case, in order to restore the deformation, the fixed support section applies a certain pulling force to the fixing piece fixed on the ventricular septum, and the pressure on the artificial heart valve during the beating of the heart is added, causing the fixing piece to keep pulling the ventricular septum, causing the muscle group of the patient's ventricular septum to be in a damaged state, causing damage to the tissue, and even causing the fixing piece to be pulled out of the ventricular septum tissue, causing the valve stent to lose fixation and fail. The present invention creatively adopts a structure that facilitates torsional deformation in the fixed support segment. Even if the distal end of the fixed support segment and the contact portion with the patient's ventricular septum do not fit the plane of the ventricular septum, it only needs to apply a small force to deform the fixed support segment, thereby avoiding the risk of failure of fixation of the fixing piece or being pulled off. Moreover, the existence of the structure that facilitates torsional deformation (especially when the structure that facilitates torsional deformation is a curved concave structure) makes the rigid connection between the valve support and the fixed point become a semi-rigid connection with a certain buffering elasticity. When the ventricle contracts and the artificial valve is compressed, the pulling and shearing forces of the valve support on the fixing piece are reduced, thereby significantly improving the durability of the artificial valve.

[0029] 5. Different from the prior art, in the present invention, the fixed support segment is provided with a structure that facilitates torsional deformation. Under the premise of ensuring that the anchor point remains unchanged, the actual length of the material of the fixed support segment will be increased, providing a larger adjustment range for the telescopic structure of the fixed support segment that is convenient for adjusting the length. Assisted by the selection of the cross-sectional diameter of the material of the fixed support segment, one specification of the heart valve prosthesis can adapt to more patients, thereby significantly reducing production and management costs.

[0030] 6. Different from the prior art, in the present invention, a plurality of leaflet lifting and blocking devices are provided: on the one hand, the plurality of leaflet lifting and blocking devices lift the leaflets and, together with the ventricular septum, provide multi-point support for the valve stent, so that the supporting force of the valve stent is uniform; on the other hand, the arrangement position of the leaflet lifting and blocking devices corresponds to the junction of the native leaflets, so that the adaptive coated stent fits more tightly at the junction of the native leaflets, thereby reducing the occurrence of paravalvular leakage at the junction of the native leaflets.

[0031] 7. Different from the concentric structure of most existing products, in the present invention, in the cross section perpendicular to the central axis of the artificial valve, the center of the valve sewing section does not coincide with the center of the adaptive coated stent. When the heart valve prosthesis is used for mitral valve interventional replacement, the central axis of the valve sewing section is biased toward the posterior valve area of ​​the patient's mitral valve, which can further reduce the obstruction to the left ventricular outflow tract; when the heart valve prosthesis is used for tricuspid valve interventional replacement, the central axis of the valve sewing section is biased toward the septal valve area of ​​the patient's tricuspid valve, which is conducive to the fixed support section being able to stick to the target anchoring area, the anchoring effect is more ideal, and the valve movement is more stable.

[0032] 8. Different from the design of most products in the prior art that use stents to support the valve ring, in the present invention, on the cross-section perpendicular to the central axis of the artificial valve, the projected area of ​​the valve sewing section is smaller than the projected area of ​​the patient's native valve ring, so that the valve sewing section will not radially expand the patient's native valve ring, which can not only reduce the impact of the stent on the outflow tract after release and avoid pulling on the native valve ring, but also ensure that the opening area of ​​the valve will not change too much due to the huge differences between the patients' valve rings, thereby optimizing the valve performance. At the same time, manufacturers can reduce product specifications and reduce the stocking pressure of manufacturers.

[0033] 9. Different from the prior art where the stents located in the atrium are mostly in the form of a grid, whose huge supporting force easily causes compression to the heart tissue and whose anti-leakage effect is unsatisfactory, the adaptive coated stent in the present invention is located in the patient's atrium and fits the patient's own valve annulus. The adaptive coated stent can conform to the uneven contour of the atrial cavity wall or the patient's own valve annulus, and the anti-leakage effect is improved.

[0034] The embodiments of the present application can achieve other advantageous technical effects that are not listed one by one. These other technical effects may be partially described below and are predictable and understandable to those skilled in the art after reading the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The above-mentioned features and advantages and other features and advantages of these embodiments and the manner in which they are achieved will become more apparent, and the embodiments of the present application can be better understood by referring to the following description together with the accompanying drawings, in which: Figure 1 A schematic diagram of the overall structure of the heart valve prosthesis of the present invention.

[0036] Figure 2 It is a schematic diagram of the connection between the valve sewing section and the fixed support section of the present invention.

[0037] Figure 3 This is a diagram showing the implanted state of the heart valve prosthesis of the present invention in the heart.

[0038] Figure 4 It is a top view of the heart valve prosthesis of the present invention after implantation, and the leaflet lifting and blocking device is located at the junction of the leaflets.

[0039] Figure 5 This is another embodiment of the heart valve prosthesis of the present invention.

[0040] Figure 6 and Figure 7 It is a schematic diagram of the twisting of the curved concave structure of the present invention, wherein the valve sewing section remains stationary and the curved concave structure rotates.

[0041] Figure 8 and Fig. 9 This is a schematic diagram of a telescopic structure according to another embodiment of the present invention.

[0042] The features indicated by the numbers in the accompanying drawings are as follows: 1-valve stent, 11-valve sewing section, 12-artificial valve, 2-fixing device, 21-fixed supporting section, 211-curved section, 212-straight section, 213-curved concave structure, 214-telescopic structure, 22-fixing piece, 3-adaptive coated stent, 4-leaflet lifting and blocking device. DETAILED DESCRIPTION

[0043] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments.

[0044] The distal end mentioned in the present invention refers to the end away from the apex of the heart, and the proximal end refers to the end close to the apex of the heart. Specific embodiments Embodiment 1

[0045] like Figure 1 and Figure 2 As shown, a heart valve prosthesis fixed through a ventricular septum according to an embodiment of the present application is illustrated, comprising a valve stent 1 and a fixing device 2, wherein the valve stent 1 comprises a valve sewing segment 11 and an artificial valve 12, wherein the artificial valve 12 is fixedly connected to the valve sewing segment 11, and the fixing device 2 comprises a fixed support segment 21 and a fixing member 22, wherein one end of the fixed support segment 21 is connected to the proximal end of the valve sewing segment 11, and the other end of the fixed support segment 21 is connected to the patient's ventricular septum through the fixing member 22 to support the heart valve prosthesis and limit the axial movement of the heart valve prosthesis.

[0046] In the first embodiment, the fixed support section 21 is provided with a curved section 211. Figure 2 As shown, the proximal portion of the fixed support segment 21 can fit the patient's ventricular septum.

[0047] In the first embodiment, the portion of the fixed support segment 21 that contacts the patient's ventricular septum is a straight line segment 212. Figure 3 shown.

[0048] In the first embodiment, the fixed support segment 21 is made of one or more rods / wires, one end of the one or more rods / wires are respectively connected to the valve sewing segment 11, and the other end of the one or more rods / wires is provided with a portion cooperating with the fixing member 22, and is connected to the patient's ventricular septum through the fixing member 22.

[0049] In the first embodiment, on the circumferential arc where the outer edge of the valve sewing segment 11 is located, the maximum arc length formed by the connection points of the multiple rods or wires and the valve sewing segment 11 is greater than or equal to one quarter of the circumference of the valve sewing segment 11.

[0050] In the first embodiment, the fixed support segment 21 is formed by extending the skeleton at the proximal end of the valve sewing segment 11 .

[0051] In the first embodiment, the heart valve prosthesis further comprises an adaptive stent graft 3, which is connected to the valve sewing section 11. In a free state, the adaptive stent graft 3 is located in the patient's atrium. The distal end of the adaptive stent graft 3 is abutted against and fixedly connected to the valve stent 1 and is circular, the middle part of the adaptive stent graft 3 is D-shaped, and the proximal end of the adaptive stent graft 3 is in contact with the atrial tissue and is elliptical or quasi-elliptical; the self-expanding stent of the adaptive stent graft 3 is integrally woven from silk material, and the coating on the self-expanding stent is a polymer flexible material, such as a PTFE film, a polyester film, etc.

[0052] In the first embodiment, the heart valve prosthesis further comprises a leaflet lifting and blocking device 4 , one end of which is fixed on the valve stent 1 , and the other end is arranged on the outside of the valve stent 1 and / or the adaptive coated stent 3 .

[0053] In the first embodiment, the location of the leaflet lifting and blocking device 4 corresponds to the junction of the native leaflets. Figure 4 shown.

[0054] In the first embodiment, the fixing member 22 is an anchoring needle, and a limiting member is provided at the tail of the anchoring needle.

[0055] In the first embodiment, on the cross section perpendicular to the central axis of the artificial valve 12, the cross-sectional area of ​​the valve sewing section 11 is smaller than the cross-sectional area of ​​the patient's native valve annulus, so that the valve sewing section 11 will not radially expand the patient's native valve annulus.

[0056] In the first embodiment, in a free state, the cross-sectional area of ​​the adaptive coated stent 3 is larger than the cross-sectional area of ​​the patient's own valve annulus. The adaptive coated stent 3 can conform to the uneven contour of the atrial cavity wall or the patient's own valve annulus without restricting the contractile function of the atrium.

[0057] In the first embodiment, on a cross section perpendicular to the central axis of the artificial valve 12, the center of the valve sewing section 11 does not coincide with the center of the adaptive stent graft 3. Figure 4 shown. Embodiment 2

[0058] The second embodiment is substantially the same as the first embodiment, except that the fixed support section 21 is provided with a structure that facilitates twisting and deformation, such as Figure 5 shown.

[0059] In this embodiment, a heart valve prosthesis fixed through a ventricular septum is introduced, including a valve stent 1 and a fixing device 2, wherein the valve stent 1 includes a valve sewing segment 11 and an artificial valve 12, wherein the artificial valve 12 is fixedly connected to the valve sewing segment 11, and the fixing device 2 includes a fixed support segment 21 and a fixing member 22, wherein one end of the fixed support segment 21 is connected to the proximal end of the valve sewing segment 11, and the other end of the fixed support segment 21 is connected to the patient's ventricular septum through the fixing member 22 to support the heart valve prosthesis and limit the axial movement of the heart valve prosthesis.

[0060] In the second embodiment, the structure that facilitates twisting deformation is a curved concave structure 213, and the curved concave-convex structure 213 is adapted to the ventricular septum with different deflection angles, such as Figure 6 and Figure 7 shown.

[0061] In this regard, the relevant structure and concept of the second embodiment are similar to those of the first embodiment, and thus will not be described again here. Embodiment 3

[0062] The third embodiment is substantially the same as the first embodiment, except that the fixed support section 21 is provided with a telescopic structure 214 for facilitating length adjustment.

[0063] In this embodiment, a heart valve prosthesis fixed through a ventricular septum is introduced, including a valve stent 1 and a fixing device 2, wherein the valve stent 1 includes a valve sewing segment 11 and an artificial valve 12, wherein the artificial valve 12 is fixedly connected to the valve sewing segment 11, and the fixing device 2 includes a fixed support segment 21 and a fixing member 22, wherein one end of the fixed support segment 21 is connected to the proximal end of the valve sewing segment 11, and the other end of the fixed support segment 21 is connected to the patient's ventricular septum through the fixing member 22 to support the heart valve prosthesis and limit the axial movement of the heart valve prosthesis.

[0064] In the third embodiment, the telescopic structure 214 provides a larger adjustment range for the fixed support segment 21, and adjusts the distance between the anchoring area and the valve sewing segment 11. Figure 8 and Fig. 9 As shown, one size of heart valve prosthesis can be adapted to more patients.

[0065] In this regard, the relevant structure and concept of the third embodiment are similar to those of the second embodiment, and thus will not be described again here.

[0066] The foregoing description of several embodiments of the present application is presented for illustrative purposes. The foregoing description is not intended to be exhaustive, nor to limit the present application to the precise configurations, constructions, and / or steps disclosed; obviously, many modifications and variations may be made in light of the above teachings. The scope of the present invention and all equivalents are intended to be defined by the appended claims.

Claims

1. A heart valve prosthesis fixed through the ventricular septum, characterized in that: The invention comprises a valve support and a fixing device, wherein the valve support comprises a valve sewing section and an artificial valve, wherein the artificial valve is fixedly connected to the valve sewing section, and the fixing device comprises a fixed support section and a fixing piece, wherein one end of the fixed support section is connected to the proximal end of the valve sewing section, and the other end of the fixed support section is connected to the patient's ventricular septum through the fixing piece to support the heart valve prosthesis and limit the axial movement of the heart valve prosthesis.

2. A heart valve prosthesis fixed through the ventricular septum according to claim 1, characterized in that: The fixed support segment is provided with a curved segment, so that the proximal end portion of the fixed support segment can fit the patient's ventricular septum.

3. A heart valve prosthesis fixed through the ventricular septum according to claim 1, characterized in that: The fixed support segment is made of one or more rods / wires, one end of the one or more rods / wires is respectively connected to the valve sewing segment, and the other end of the one or more rods / wires is provided with a portion cooperating with a fixing device, and is connected to the patient's ventricular septum through the fixing device; on the circumferential arc where the outer edge of the valve sewing segment is located, the maximum arc length formed by the connection points of the multiple rods or wires and the valve sewing segment is greater than or equal to one quarter of the circumference of the valve sewing segment.

4. A heart valve prosthesis fixed through the ventricular septum according to claim 1, characterized in that: The fixed support section is provided with a structure that facilitates torsional deformation.

5. A heart valve prosthesis fixed through the ventricular septum according to claim 4, characterized in that: The structure that facilitates twisting and deformation is a curved concave structure.

6. A heart valve prosthesis fixed through the ventricular septum according to claim 1 or 4, characterized in that: The fixed support section is provided with a telescopic structure for facilitating length adjustment.

7. The heart valve prosthesis fixed through the ventricular septum according to claim 1, characterized in that: The heart valve prosthesis also includes an adaptive stent graft.

8. A heart valve prosthesis fixed through the ventricular septum according to claim 7, characterized in that: The heart valve prosthesis also includes a leaflet lifting and blocking device.

9. A heart valve prosthesis fixed through the ventricular septum according to claim 8, characterized in that: One end of the leaflet lifting and blocking device is fixed on the valve stent, and the other end is arranged on the outside of the valve stent and / or the adaptive coated stent; the setting position of the leaflet lifting and blocking device corresponds to the junction of the autologous leaflets.

10. The heart valve prosthesis fixed through the ventricular septum according to claim 1, characterized in that: In a cross section perpendicular to the central axis of the artificial valve, the cross-sectional area of ​​the valve sewing section is smaller than the cross-sectional area of ​​the patient's native valve annulus, so that the valve sewing section will not radially expand the patient's native valve annulus.

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