Film-forming agent composition as well as preparation method and application of film-forming agent composition

Abstract

The invention discloses a film-forming agent composition as well as a preparation method and application of the film-forming agent composition. The film-forming agent composition is prepared from the following components in percentage by weight: 0.2 to 2 percent of hyaluronic acid and / or hyaluronate, 15 to 40 percent of polyhydric alcohol, 0.5 to 2 percent of gluconolactone and / or lactobionic acid lactone, and the balance of deionized water. The film-forming agent composition provided by the invention is obtained by adding a proper amount of polyol, gluconolactone and / or lactobionic acid lactone into an aqueous solution of active substance hyaluronic acid and / or hyaluronate, the polyhydric alcohol, gluconolactone and / or lactobionic acid lactone can form hydrogen bonds with the active substances hyaluronic acid and hyaluronate, and a complex hydrogen bond net can be formed by mixing the polyhydric alcohol, gluconolactone and / or lactobionic acid lactone with the active substances hyaluronic acid and hyaluronate, so that the flexibility of the film-forming agent composition can be greatly improved, the film-forming effect is good, the comprehensive performance of a formed film is excellent, and the film-forming agent composition can be widely applied to the field of film forming. The compound can be used as a film-forming agent to be applied to cosmetics and skin care products in the field of cosmetics and medicines in the field of medicines.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products and pharmaceuticals, and in particular to a film-forming agent composition, a preparation method of the film-forming agent composition and application thereof. Background Art

[0002] Hyaluronic acid is a component of the interstitial matrix of human cells, which has various physiological functions. Most of the hyaluronic acid and hyaluronate salts available on the market are excellent biomaterials with good biocompatibility obtained through microbial fermentation and purification, and have a wide range of uses in the cosmetics and pharmaceutical fields. For example, hyaluronic acid and hyaluronate salts are often used as excellent moisturizers in the cosmetics field due to their strong ability to bind water molecules.

[0003] Film-forming agents are widely used in the cosmetics field, such as maintaining the stability of makeup in setting products, achieving uniform dispersion of sunscreen agents and enhancing the sunscreen effect in sunscreen products, preventing adhesion in the medical field, etc.

[0004] Hyaluronic acid and hyaluronates themselves have excellent film-forming ability, but due to their linear molecular structure and weak toughness, they are difficult to use as film-forming agents in the pharmaceutical and cosmetic fields.

[0005] In view of this, it is indeed necessary to provide a technical solution to the above problems. Summary of the invention

[0006] The purpose of the present invention is to address the deficiencies of the prior art and to provide a film-forming agent composition, a preparation method of a film-forming agent combination and an application thereof, so that hyaluronic acid and / or hyaluronate can be used as an active substance to make a film-forming agent for application in the cosmetics and pharmaceutical fields.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] A film-forming agent composition comprises the following components by weight percentage: 0.2-2% of hyaluronic acid and / or hyaluronate, 15-40% of polyol, 0.5-2% of gluconolactone and / or lactobionolactone, and deionized water making up the balance.

[0009] In some embodiments, the film-forming agent composition comprises the following components in percentage by weight:

[0010] The hyaluronic acid and / or hyaluronate is 0.5-1%, the polyol is 20-30%, the gluconolactone and / or lactobionolactone is 0.5-1%, and the balance is made up with deionized water.

[0011] In some embodiments, the molecular weight of the hyaluronic acid in the film-forming agent composition is 50W to 300W; and / or the molecular weight of the hyaluronate is 50W to 300W.

[0012] In some embodiments, the molecular weight of the hyaluronic acid in the film-forming agent composition is 100W to 220W; and / or the molecular weight of the hyaluronate is 100W to 220W.

[0013] In some embodiments, the hyaluronate in the film-forming agent composition is selected from at least one of sodium hyaluronate, potassium hyaluronate, and calcium hyaluronate.

[0014] In some embodiments, the polyol in the film-forming agent composition is selected from at least one of glycerol, propylene glycol, and butylene glycol.

[0015] The present invention also aims to provide a method for preparing a film-forming agent composition. The content of each component of the raw materials involved below is calculated by weight percentage of the film-forming agent composition. The preparation method comprises the following steps:

[0016] Adding 0.2-2% of hyaluronic acid and / or hyaluronate to 15-40% of polyol and dispersing them to obtain a first mixture;

[0017] Adding the first batch of deionized water to the first mixture and stirring evenly to obtain a first mixed solution;

[0018] adding 0.5-2% of gluconolactone and / or lactobionolactone into the second batch of deionized water for dissolution to obtain a second mixed solution;

[0019] Mixing the first mixed solution and the second mixed solution uniformly to obtain the film-forming agent composition;

[0020] The deionized water content of the first batch accounts for 60-80% of the total weight of the deionized water; the deionized water content of the second batch accounts for 20-40% of the total weight of the deionized water.

[0021] The present invention also aims to provide the use of the film-forming agent composition as a film-forming agent in the preparation of a makeup setting product in the field of cosmetics.

[0022] The present invention also aims to provide the use of the film-forming agent composition as a film-forming agent in the preparation of sunscreen products in the cosmetics field.

[0023] The present invention also aims to provide the use of the film-forming agent composition as a film-forming agent in the preparation of medicines in the medical field.

[0024] The beneficial effects of the present invention are:

[0025] The film-forming agent composition provided by the present invention comprises the following components by weight percentage: 0.2-2% of hyaluronic acid and / or hyaluronate, 15-40% of polyol, 0.5-2% of gluconolactone and / or lactobionic acid lactone, and deionized water to make up the balance. That is, the film-forming agent composition provided by the present invention is obtained by adding an appropriate amount of polyol, gluconolactone and / or lactobionic acid lactone to an aqueous solution of active substance hyaluronic acid and / or hyaluronate; since polyol, gluconolactone and / or lactobionic acid lactone can form hydrogen bonds with active substance hyaluronic acid and hyaluronate, the three can be mixed together to form a complex hydrogen bond network, thereby greatly improving the flexibility of the film-forming agent composition, having a good film-forming effect and excellent comprehensive film-forming performance, and can be used as a film-forming agent in cosmetics and skin care products in the cosmetics field, as well as in medicines in the medical field. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 Schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 1 of the present invention;

[0027] Figure 2 Schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 16 of the present invention;

[0028] Figure 3 Schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 18 of the present invention;

[0029] Figure 4 Schematic diagram of the flat film-forming effect of the composition prepared in Comparative Example 1 of the present invention;

[0030] Figure 5 It is a schematic diagram of the flat film-forming effect of the composition prepared in Comparative Example 2 of the present invention. DETAILED DESCRIPTION

[0031] To make the technical solutions and advantages of the present invention more clear, the present invention and its beneficial effects will be further described in detail below in conjunction with specific implementation methods, but the implementation methods of the present invention are not limited thereto.

[0032] The film-forming agent composition provided by the present invention, in order to achieve the above-mentioned purpose, adopts the following technical scheme:

[0033] A film-forming agent composition comprises the following components by weight percentage: 0.2-2% of hyaluronic acid and / or hyaluronate, 15-40% of polyol, 0.5-2% of gluconolactone and / or lactobionolactone, and deionized water making up the balance.

[0034] In some embodiments, the film-forming agent composition comprises the following components in percentage by weight:

[0035] The hyaluronic acid and / or hyaluronate is 0.5-1%, the polyol is 20-30%, the gluconolactone and / or lactobionolactone is 0.5-1%, and the balance is made up with deionized water.

[0036] In some embodiments, the molecular weight of the hyaluronic acid in the film-forming agent composition is 50W to 300W; and / or the molecular weight of the hyaluronate is 50W to 300W.

[0037] In some embodiments, the molecular weight of the hyaluronic acid in the film-forming agent composition is 100W to 220W; and / or the molecular weight of the hyaluronate is 100W to 220W.

[0038] In the molecular weight described in the present invention, W represents ten thousand, for example, 50W represents a molecular weight of 500,000, and can also represent a molecular weight of 500,000 Da, that is, a molecular weight of 500,000 is equal to a molecular weight of 500,000 Da.

[0039] The molecular weight of the hyaluronic acid and / or hyaluronate used in the film-forming agent composition provided by the present invention should not be too small or too large. If the molecular weight is too small, the molecular chain is too short, the intermolecular force is too weak, and it is difficult to form a continuous film structure. If the molecular weight is too large, the molecular chain is too long, the intermolecular force is too strong, and it will be too viscous to form a continuous film.

[0040] In some embodiments, the hyaluronate in the film-forming agent composition is selected from at least one of sodium hyaluronate, potassium hyaluronate, and calcium hyaluronate.

[0041] In some embodiments, the polyol in the film-forming agent composition is selected from at least one of glycerol, propylene glycol, and butylene glycol.

[0042] The present invention also aims to provide a method for preparing a film-forming agent composition. The content of each component of the raw materials involved below is calculated by weight percentage of the film-forming agent composition. The preparation method comprises the following steps:

[0043] Adding 0.2-2% of hyaluronic acid and / or hyaluronate to 15-40% of polyol and dispersing them to obtain a first mixture;

[0044] Adding the first batch of deionized water to the first mixture and stirring evenly to obtain a first mixed solution;

[0045] adding 0.5-2% of gluconolactone and / or lactobionolactone into the second batch of deionized water for dissolution to obtain a second mixed solution;

[0046] Mixing the first mixed solution and the second mixed solution uniformly to obtain the film-forming agent composition;

[0047] The deionized water content of the first batch accounts for 60-80% of the total weight of the deionized water; the deionized water content of the second batch accounts for 20-40% of the total weight of the deionized water.

[0048] The film-forming agent composition of the present invention is used as a film-forming agent in the preparation of a makeup-fixing product in the field of cosmetics.

[0049] The film-forming agent composition of the present invention is used as a film-forming agent in the preparation of sunscreen products in the cosmetics field.

[0050] The film-forming agent composition of the present invention is used as a film-forming agent in the preparation of medicines in the medical field.

[0051] Embodiment 1:

[0052] The film-forming agent composition is prepared. The content of the following components is calculated as a percentage by weight of the film-forming agent composition. The specific steps for preparing the film-forming agent composition are as follows:

[0053] 0.5% of hyaluronic acid with a molecular weight of 100W is added to 20% of glycerol and stirred to disperse evenly to obtain a first mixture. The first batch of deionized water is added to the first mixture and stirred to obtain a first mixed solution. 0.5% of gluconolactone is added to the second batch of deionized water for dissolution to obtain a second mixed solution. The first mixed solution and the second mixed solution are mixed evenly to obtain the film-forming agent composition of Example 1. The deionized water content of the first batch accounts for 80% of the total weight of the deionized water; the deionized water content of the second batch accounts for 20% of the total weight of the deionized water.

[0054] Examples 2 to 24

[0055] Repeat the steps of Example 1 according to the component types and content parameters specified in Examples 2 to 24 in Table 1. See Table 1 for details.

[0056] Comparative Examples 1 to 4

[0057] The steps of Example 1 were repeated according to the various component types and content parameters specified in Comparative Examples 1 to 4 in Table 1. See Table 1 for details.

[0058] Table 1 shows the types and content parameters of the components of the film-forming agent compositions prepared in Examples 1 to 24 and Comparative Examples 1 to 4.

[0059] Table 1:

[0060]

[0061]

[0062]

[0063] The performance tests of Examples 1-24 and Comparative Examples 1-4 were compared, and the test items and test methods were as follows:

[0064] 1. Flexibility: Take 10 g of each of the film-forming agent compositions prepared in Examples 1-24 and Comparative Examples 1-4 as test products, apply them on a smooth table with an area of ​​5CM*5CM respectively, observe the flexibility of the test products after drying at room temperature for 4 hours, and score the flexibility with 1-10 points within a reasonable skin feel range. The better the flexibility, the higher the score.

[0065] 2. Ductility: Take 0.04 g of each of the film-forming agent compositions prepared in Examples 1-24 and Comparative Examples 1-4 as test products, apply them on plastic sheets respectively, stretch the plastic sheets after drying to observe the ductility of the test products, and score the ductility on a scale of 1 to 10 within a reasonable skin feel range. The better the ductility, the higher the score.

[0066] 3. Spreadability: Take 0.04 g of each of the film-forming agent compositions prepared in Examples 1-24 and Comparative Examples 1-4 as test products, apply them on artificial leather respectively, observe the spreadable range of the test products during the application process, and score the spreadability with 1-10 points within a reasonable skin feel range. The larger the application range, the higher the score.

[0067] 4. Smoothness: Take 0.04 g of each of the film-forming agent compositions prepared in Examples 1-24 and Comparative Examples 1-4 as test products, apply them on surface dishes respectively, observe the smoothness of the test products after drying, and score the smoothness on a scale of 1 to 10 within a reasonable skin feel range. The smoother and smoother the test products, the higher the score.

[0068] 5. Glossiness: Take 0.04 g of each of the film-forming agent compositions of Examples 1-24 and Comparative Examples 1-4 as test products, apply them on surface dishes respectively, observe the color and gloss of the test products after drying, and score the glossiness on a scale of 1 to 10 within a reasonable skin feel range. The brighter the gloss, the higher the score.

[0069] 6. Skin fit: Take 0.04 g of each of the film-forming agent compositions prepared in Examples 1-24 and Comparative Examples 1-4 as test products, and apply them on artificial leather respectively. During the application process, observe whether the test products fit the artificial leather. Score the skin fit within a reasonable skin feel range of 1-10 points. The higher the skin fit, the higher the score.

[0070] 7. Abrasion resistance: Take 0.04 g of each of the film-forming agent compositions of Examples 1-24 and Comparative Examples 1-4 as test products, apply them on sub-surface dishes respectively, and after drying, rub the test products back and forth 5 times with your fingertips to observe the abrasion resistance and powder output of the test products. Score the abrasion resistance on a scale of 1 to 10 within a reasonable skin feel range. The smaller the degree of abrasion, the less likely it is to produce powder and the higher the score.

[0071] 8. Stickiness: Take 0.04 g of each of the film-forming agent compositions of Examples 1-24 and Comparative Examples 1-4 as test products, apply them on artificial leather respectively, observe the residue of the test products on the surface of the artificial leather and the stickiness after drying, and score the stickiness on 1-10 points within a reasonable skin feel range. The stickier, the lower the score.

[0072] As shown in Table 2, Table 2 is the test results of various performance indicators of the film-forming agent compositions of Examples 1-24 and Comparative Examples 1-4.

[0073] Table 2:

[0074]

[0075]

[0076]

[0077] It can be seen from the test result data in Table 2 that the film-forming agent composition provided in the embodiments of the present invention is obtained by adding an appropriate amount of polyol, gluconolactone and / or lactobionic acid lactone to an aqueous solution of active substances hyaluronic acid and / or hyaluronate; since polyol, gluconolactone and / or lactobionic acid lactone can form hydrogen bonds with the active substances hyaluronic acid and hyaluronate, the three mixed together can form a complex hydrogen bond network, which can greatly improve the flexibility of the film-forming agent composition, and the film-forming effect is good. At the same time, the film-forming agent composition provided in the embodiments of the present invention has good ductility, spreadability, wear resistance, smoothness, glossiness, as well as skin-fitting and sticky feeling. The score value of each performance item is basically above 6 points, and the comprehensive score is as high as 60 points or more. The comprehensive score of the performance items of the film-forming agent composition provided in some embodiments exceeds 70 points, and the comprehensive performance of film-forming is excellent. It can be used as a film-forming agent in cosmetics and skin care products in the cosmetics field, and in medicines in the medical field. See Figure 1 and Figure 2 , Figure 1 Schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 1 of the present invention, Figure 2 Schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 16 of the present invention; Figure 3 It is a schematic diagram of the flat film-forming effect of the film-forming agent composition prepared in Example 18 of the present invention.

[0078] The composition prepared in Comparative Example 1 is a simple hyaluronic acid aqueous solution, which has a poor film-forming effect and the obtained transparent film is brittle and thin; Figure 4 , Figure 4 Schematic diagram of the film-forming effect of the composition prepared in comparative example 1 of the present invention; the composition prepared in comparative example 3 is a composition in which gluconolactone is added to a hyaluronic acid aqueous solution, and its film-forming effect is extremely poor; from the score values ​​of each performance item in Table 1, it can be seen that the film-forming performance of the compositions corresponding to comparative examples 1 and 3 is poor. The compositions prepared in comparative examples 2 and 4 are a composition in which polyols are added to a hyaluronic acid aqueous solution; the obtained compositions cannot form a film when spread on a smooth table, see Figure 5 , Figure 5 It is a schematic diagram of the flat film-forming effect of the composition prepared in Comparative Example 2 of the present invention. The difference between the composition prepared in Comparative Example 5 and Example 1 is that low molecular weight hyaluronic acid is used; the difference between the composition prepared in Comparative Example 6 and Example 11 is that low molecular weight hyaluronic acid and low molecular weight sodium hyaluronate are used. From the score values ​​of each performance item in Table 1, it can be seen that the film-forming properties of the compositions corresponding to Comparative Examples 5 and 6 are poor, and the scores of ductility, smoothness, glossiness, skin-fitting feel, wear resistance, and stickiness are relatively low. This is because when the molecular weight of hyaluronic acid and sodium hyaluronate is too small, the molecular chain is too short, and the intermolecular force is relatively weak, making it difficult to form a good film structure.

[0079] In summary, the film-forming agent composition provided by the present invention comprises the following components by weight percentage: 0.2-2% hyaluronic acid and / or hyaluronate, 15-40% polyol, 0.5-2% gluconolactone and / or lactobionic acid lactone, and deionized water to make up the balance. That is, the film-forming agent composition provided by the present invention is obtained by adding an appropriate amount of polyol, gluconolactone and / or lactobionic acid lactone to an aqueous solution of active substance hyaluronic acid and / or hyaluronate; since polyol, gluconolactone and / or lactobionic acid lactone can form hydrogen bonds with active substance hyaluronic acid and hyaluronate, the three can be mixed together to form a complex hydrogen bond network, thereby greatly improving the flexibility of the film-forming agent composition, and the film-forming effect is good, and the comprehensive performance of the film-forming is excellent, and it can be used as a film-forming agent in cosmetics and skin care products in the cosmetics field, as well as in medicines in the medical field.

[0080] Those skilled in the art may combine and associate different embodiments or examples and features of different embodiments or examples described in this specification without mutual contradiction.

[0081] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of various equivalent modifications or replacements within the technical scope disclosed by the present invention, and these modifications or replacements should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be based on the protection scope of the claims.

Claims

1. A film-forming agent composition, characterized in that The invention comprises the following components by weight percentage: 0.2-2% of hyaluronic acid and / or hyaluronic acid salt, 15-40% of polyol, 0.5-2% of gluconolactone and / or lactobionolactone, and deionized water making up the balance.

2. The film-forming agent composition according to claim 1, characterized in that The contents of the components in percentage by weight are as follows: The hyaluronic acid and / or hyaluronate is 0.5-1%, the polyol is 20-30%, the gluconolactone and / or lactobionolactone is 0.5-1%, and the balance is made up with deionized water.

3. The film-forming agent composition according to claim 1 or 2, characterized in that: The molecular weight of the hyaluronic acid is 50W to 300W; and / or the molecular weight of the hyaluronate is 50W to 300W.

4. The film-forming agent composition according to claim 3, characterized in that The molecular weight of the hyaluronic acid is 100W to 220W; and / or the molecular weight of the hyaluronate is 100W to 220W.

5. The film-forming agent composition according to claim 1 or 2, characterized in that: The hyaluronate is selected from at least one of sodium hyaluronate, potassium hyaluronate and calcium hyaluronate.

6. The film-forming agent composition according to claim 1 or 2, characterized in that: The polyol is selected from at least one of glycerol, propylene glycol and butylene glycol.

7. A method for preparing a film-forming agent composition, characterized in that: The content of each component of the raw materials involved below is calculated by weight percentage of the film-forming agent composition. The preparation method comprises the following steps: Adding 0.2-2% of hyaluronic acid and / or hyaluronate to 15-40% of polyol and dispersing them to obtain a first mixture; Adding the first batch of deionized water to the first mixture and stirring evenly to obtain a first mixed solution; adding 0.5-2% of gluconolactone and / or lactobionolactone into the second batch of deionized water for dissolution to obtain a second mixed solution; Mixing the first mixed solution and the second mixed solution uniformly to obtain the film-forming agent composition; The deionized water content of the first batch accounts for 60-80% of the total weight of the deionized water; the deionized water content of the second batch accounts for 20-40% of the total weight of the deionized water.

8. Use of the film-forming agent composition according to any one of claims 1 to 6 as a film-forming agent in the preparation of a makeup-fixing product in the field of cosmetics.

9. Use of the film-forming agent composition according to any one of claims 1 to 6 as a film-forming agent in the preparation of sunscreen products in the cosmetics field.

10. Use of the film-forming agent composition according to any one of claims 1 to 6 as a film-forming agent in the preparation of medicines in the medical field.

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