Hypolipidemic composition containing spina date seed extract and preparation method of hypolipidemic composition

Abstract

The invention provides a blood fat reducing composition containing a spina date seed extract and a preparation method of the blood fat reducing composition, and belongs to the technical field of medicines. The blood fat reducing composition disclosed by the invention is prepared from 160 to 250 parts of semen ziziphi spinosae extract, 50 to 160 parts of fructus hippophae extract, 100 to 150 parts of theanine, 80 to 100 parts of Y-aminobutyric acid, 80 to 100 parts of phosphatidylserine, 32 to 55 parts of microcrystalline cellulose, 18 to 30 parts of sorbitol and 8 to 15 parts of magnesium stearate. The blood fat reducing composition provided by the invention not only can reduce the synthesis of cholesterol in the liver to achieve the effect of treating hyperlipidemia, but also has certain intervention and treatment effects on diseases related to abnormal blood fat rise. Meanwhile, the blood fat reducing composition provided by the invention is relatively simple in components, convenient to use and beneficial to quality control of the blood fat reducing composition.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, and in particular to a lipid-lowering composition containing a spinosa jujube seed extract and a preparation method thereof. Background Art

[0002] Hyperlipidemia, also known as high blood lipids or dyslipidemia, usually refers to a lipid metabolism disorder caused by abnormal lipid metabolism or operation. The occurrence of this disease can be seen in people of different ages and genders, especially in people aged 55-70 years old, and there is a clear genetic tendency. The causes of hyperlipidemia include bad eating habits, lack of physical activity, environmental factors, gene mutations, etc. The disease is characterized by increased levels of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) or decreased levels of high-density lipoprotein cholesterol (HDL-C) in serum. The main types include hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia and high and low-density lipoproteinemia. In addition to causing disorders in human physiological functions and metabolism, hyperlipidemia can also cause some other complications, especially cardiovascular and cerebrovascular diseases, including atherosclerosis, obesity, fatty liver, etc.

[0003] At present, the drugs used clinically to regulate blood lipids mainly include statins, clofibrate and phenoxyacetic acid, bile acid chelators, niacin and other lipid-regulating drugs to treat hyperlipidemia. Although the use of Western medicine to treat hyperlipidemia has certain effects, long-term use of such drugs has many side effects, such as gastrointestinal reactions such as acid reflux, nausea, vomiting, decreased appetite, abdominal distension, etc., damage to liver cells to reduce the liver's metabolism and detoxification ability, may damage muscle fibers to cause muscle soreness, and also affect the function of pancreatic B cells to secrete insulin, thereby causing metabolic disorders in the body, accelerating the increase in blood sugar levels in the body, and increasing the risk of diabetes.

[0004] Compared with Western medicine, Chinese medicine as a natural medicine has the advantages of safety, few side effects, no damage to the gastrointestinal tract, and little stimulation to the liver and kidneys, which has attracted widespread attention. However, Chinese medicine currently has problems such as slow onset, long treatment time, and inconvenient medication. In addition, taking Chinese medicine usually requires boiling the raw materials before consumption, and the taste is bitter, resulting in poor compliance of people to Chinese medicine. Chinese invention patent application number CN201511022667.2 discloses a lipid-lowering Chinese medicine composition, which is made of the following raw materials in parts by mass: 22-28 parts of ginseng, 22-28 parts of astragalus, 18-28 parts of ampelopsis heterophylla, 18-28 parts of garlic, 18-28 parts of bupleurum, 16-24 parts of angelica dahurica, 16-24 parts of radish seeds, 14-20 parts of moutan bark, 14-20 parts of glossy privet fruit, 10-20 parts of intermittent extract, 5-15 parts of polygonatum, 5-15 parts of dandelion, 5-15 parts of allium macrostemon, 5-15 parts of elm seeds, 5-15 parts of eggplant, 5-7 parts of ophiopogon, 5-7 parts of ginkgo leaves, and 3-5 parts of cnidium cyrtonema. The Chinese invention patent with application number CN201510903810.2 discloses a composition for lowering blood lipids, which is composed of the following materials in parts by weight: 6-8 parts of Polygonum cuspidatum, 8-12 parts of Momordica charantia, 12-15 parts of Bupleurum chinense, 15-20 parts of Rhubarb, 15-18 parts of Ophiopogon japonicus, 8-10 parts of Lycium barbarum, 10-15 parts of Herba Discoloris, 20-25 parts of Chinese Yam, and 6-8 parts of Morus alba. Although these compositions have certain blood lipid-lowering effects, they are all made of a simple combination of multiple natural Chinese herbal medicines, which are not only quite complex in composition, but also inconvenient to use and have a poor taste. Summary of the invention

[0005] In view of this, the present invention provides a method for preparing a lipid-lowering composition containing a jujube seed extract, comprising the following steps: uniformly mixing a jujube seed extract, a seabuckthorn extract, theanine, γ-aminobutyric acid, and phosphatidylserine, and then adding microcrystalline cellulose, sorbitol, and magnesium stearate to mix and granulate to obtain the composition.

[0006] Preferably, the extraction method of the Chinese jujube seed extract comprises the following steps: drying the Chinese jujube seed at 60-80°C for 18-24h, crushing and sieving, then placing the sieve under 3-5 times the volume of petroleum ether and heating and refluxing at 60-65°C for 2-3h, taking out the residue, drying, grinding and crushing it, and then refluxing and extracting it with 15-20 times the concentration of 75% ethanol at 60-80°C for 1-2h, and then drying, grinding and crushing the obtained residue, adding 2-3 times the water and refluxing extracting it twice, the first time heating and refluxing at 65°C for 2h, and the second time heating and refluxing at 60°C for 1h, standing and cooling, and then filtering, combining the extracts obtained after each extraction, concentrating, adding 95% ethanol for alcohol precipitation to obtain a flocculent precipitate, and freeze-drying the precipitate into a powder, which is the Chinese jujube seed extract.

[0007] Preferably, the method for extracting the seabuckthorn extract comprises the following steps:

[0008] (1) drying fresh sea buckthorn at 60-80° C. for 18-24 hours, crushing and sieving to obtain sea buckthorn powder, then mixing the sea buckthorn powder with petroleum ether at a solid-liquid ratio of 1:3, heating and refluxing extraction twice, the first heating and refluxing at 65° C. for 2 hours, the second heating and refluxing at 65° C. for 1 hour, standing and cooling, pouring out the oil layer, and recovering the petroleum ether by using a rotary evaporator at 55° C. under reduced pressure, then placing in a fume hood and evaporating to constant weight to obtain defatted sea buckthorn powder;

[0009] (2) adding defatted seabuckthorn powder to 75-95% ethanol solution at a solid-liquid ratio of 1:20-30, then adding cyclodextrin and 1-methyl-3-n-octylimidazole bromide, mixing evenly, and performing ultrasonic extraction for 10-20 minutes at a temperature of 55-65° C. to obtain a seabuckthorn extract.

[0010] Preferably, the lipid-lowering composition comprises the following components in parts by weight: 160-250 parts of jujube seed extract, 50-160 parts of sea buckthorn extract, 100-150 parts of theanine, 80-100 parts of γ-aminobutyric acid, 80-100 parts of phosphatidylserine, 32-55 parts of microcrystalline cellulose, 18-30 parts of sorbitol and 8-15 parts of magnesium stearate.

[0011] Further preferably, the lipid-lowering composition comprises the following components in parts by weight: 180-230 parts of jujube seed extract, 80-100 parts of sea buckthorn extract, 120-130 parts of theanine, 90-95 parts of γ-aminobutyric acid, 90-95 parts of phosphatidylserine, 45-50 parts of microcrystalline cellulose, 23-28 parts of sorbitol and 10-12 parts of magnesium stearate.

[0012] More preferably, the lipid-lowering composition comprises the following components in parts by weight: 200 parts of spinosa jujube seed extract, 90 parts of sea buckthorn extract, 125 parts of theanine, 93 parts of γ-aminobutyric acid, 93 parts of phosphatidylserine, 48 parts of microcrystalline cellulose, 25 parts of sorbitol and 11 parts of magnesium stearate.

[0013] The present invention also provides the blood lipid lowering composition containing the spiny jujube seed extract and the application of the blood lipid lowering composition containing the spiny jujube seed extract in the production and treatment of hyperlipidemia drugs.

[0014] Preferably, the dosage form of the lipid-lowering composition is selected from various pharmaceutically acceptable dosage forms.

[0015] Compared with the prior art, the present invention has the following beneficial effects: the present invention uses a specific proportion of spiny jujube seed extract, seabuckthorn extract, theanine, γ-aminobutyric acid, and phosphatidylserine as main raw materials, and uses microcrystalline cellulose, sorbitol, and magnesium stearate as auxiliary materials, and after reasonable combination, it has been found through research that taking the composition of the present invention can not only reduce the synthesis of cholesterol in the liver, thereby achieving the effect of treating hyperlipidemia, but also has a certain intervention and treatment effect on diseases related to abnormally elevated blood lipids, and these diseases include but are not limited to atherosclerosis, hypertension, and hyperglycemia. DETAILED DESCRIPTION

[0016] In one embodiment of the present invention, the present invention provides a method for preparing a lipid-lowering composition containing a jujube seed extract, comprising the following steps: uniformly mixing the jujube seed extract, seabuckthorn extract, theanine, γ-aminobutyric acid, and phosphatidylserine, and then adding microcrystalline cellulose, sorbitol, and magnesium stearate to mix and granulate to obtain the composition.

[0017] In one embodiment of the present invention, the extraction method of the Chinese jujube seed extract comprises the following steps: drying the Chinese jujube seed at 60-80°C for 18-24h, crushing and sieving, then placing the sieve under 3-5 times the volume of petroleum ether and heating and refluxing at 60-65°C for 2-3h, taking out the residue, drying, grinding and crushing it, and then refluxing and extracting it with 15-20 times the concentration of 75% ethanol at 60-80°C for 1-2h, and then drying and grinding the obtained residue again, adding 2-3 times the water and refluxing and extracting it twice, the first time heating and refluxing at 65°C for 2h, and the second time heating and refluxing at 60°C for 1h, standing and cooling, and then filtering, combining the extracts obtained after each extraction, concentrating, adding 95% ethanol for alcohol precipitation to obtain a flocculent precipitate, and freeze-drying the precipitate into a powder, which is the Chinese jujube seed extract.

[0018] Further preferably, the extraction method of the Chinese jujube seed extract comprises the following steps: placing the Chinese jujube seed in an oven, drying it at 60°C for 24 hours, crushing it and passing it through an 80-mesh stainless steel rotary vibrating sieve, then placing the sieve under 5 times the volume of petroleum ether and heating it at 65°C for reflux extraction for 3 hours, taking out the residue, drying it, grinding it, and then reflux extracting it with 20 times the concentration of 75% ethanol at 80°C for 2 hours, drying the obtained residue again, grinding it, adding 3 times the water for reflux extraction twice, the first time heating and reflux extraction at 65°C for 2 hours, and the second time heating and reflux extraction at 60°C for 1 hour, standing and cooling it, filtering it, combining the extracts obtained after each extraction, concentrating it, adding 95% ethanol for alcohol precipitation to obtain a flocculent precipitate, and freeze-drying the precipitate into a powder, which is the Chinese jujube seed extract.

[0019] In one embodiment of the present invention, the method for extracting seabuckthorn extract comprises the following steps:

[0020] (1) Dry fresh sea buckthorn at 60-80° C. for 18-24 h, crush and sieve to obtain sea buckthorn powder, then mix the sea buckthorn powder with petroleum ether at a solid-liquid ratio of 1:3 (g / mL), heat and reflux extraction twice, the first time at 65° C. for 2 hours, and the second time at 65° C. for 1 hour, stand and cool, pour out the oil layer, use a rotary evaporator at 55° C. to recover the petroleum ether under reduced pressure, then place in a fume hood and evaporate to constant weight to obtain defatted sea buckthorn powder;

[0021] (2) adding defatted seabuckthorn powder to 75-95% ethanol solution at a solid-liquid ratio of 1:20-30, then adding cyclodextrin and 1-methyl-3-n-octylimidazole bromide, mixing evenly, and performing ultrasonic extraction for 10-20 minutes at a temperature of 55-65° C. to obtain a seabuckthorn extract.

[0022] Further preferably, the method for extracting the seabuckthorn extract comprises the following steps:

[0023] (1) Dry fresh sea buckthorn in an oven at 60° C. for 24 h, crush and sieve through a 40-mesh sieve to obtain sea buckthorn powder, and then defatting the sea buckthorn powder, the specific steps of which are: mix the sea buckthorn powder with petroleum ether in a solid-liquid ratio of 1:3 (g / mL), heat and reflux extract twice, the first time at 65° C. for 2 hours, and the second time at 65° C. for 1 hour, stand and cool, pour out the oil layer, use a rotary evaporator at 55° C. to recover the petroleum ether under reduced pressure, then place in a fume hood and evaporate to constant weight to obtain defatted sea buckthorn powder;

[0024] (2) adding defatted seabuckthorn powder to 75% ethanol solution at a solid-liquid ratio of 1:30, then adding cyclodextrin and 1-methyl-3-n-octylimidazole bromide, mixing well, and performing ultrasonic extraction at 65° C. for 10 min to obtain seabuckthorn extract.

[0025] The extraction method of the seabuckthorn extract provided by the invention can improve the bioavailability of the seabuckthorn extract and further improve the lipid-lowering effect of the composition.

[0026] In one embodiment of the present invention, the blood lipid lowering composition comprises the following components in parts by weight: 160-250 parts of jujube seed extract, 50-160 parts of sea buckthorn extract, 100-150 parts of theanine, 80-100 parts of γ-aminobutyric acid, 80-100 parts of phosphatidylserine, 32-55 parts of microcrystalline cellulose, 18-30 parts of sorbitol, and 8-15 parts of magnesium stearate. Further preferably, the blood lipid lowering composition comprises the following components in parts by weight: 180-230 parts of jujube seed extract, 80-100 parts of sea buckthorn extract, 120-130 parts of theanine, 90-95 parts of γ-aminobutyric acid, 90-95 parts of phosphatidylserine, 45-50 parts of microcrystalline cellulose, 23-28 parts of sorbitol, and 10-12 parts of magnesium stearate. More preferably, the lipid-lowering composition comprises the following components in parts by weight: 200 parts of spinosa jujube seed extract, 90 parts of sea buckthorn extract, 125 parts of theanine, 93 parts of γ-aminobutyric acid, 93 parts of phosphatidylserine, 48 parts of microcrystalline cellulose, 25 parts of sorbitol and 11 parts of magnesium stearate.

[0027] The present invention also provides the blood lipid lowering composition containing the spiny jujube seed extract and the application of the blood lipid lowering composition containing the spiny jujube seed extract in the production and treatment of hyperlipidemia drugs.

[0028] In one embodiment of the present invention, the dosage form of the lipid-lowering composition is selected from various pharmaceutically acceptable dosage forms, such as tablets, capsules, oral solutions, lozenges, injections, ointments, granules or various sustained-release preparations.

[0029] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0030] Example 1

[0031] A method for preparing a lipid-lowering composition containing a spiny jujube seed extract, comprising the following steps: uniformly mixing 200 parts of a spiny jujube seed extract, 90 parts of a sea buckthorn extract, 125 parts of theanine, 93 parts of γ-aminobutyric acid, and 93 parts of phosphatidylserine in proportion, and then adding 48 parts of microcrystalline cellulose, 25 parts of sorbitol, and 11 parts of magnesium stearate, and mixing and granulating to obtain a lipid-lowering composition powder containing a spiny jujube seed extract;

[0032] The extraction method of the Chinese jujube seed extract is as follows: placing the Chinese jujube seed in an oven, drying it at 60°C for 24 hours, crushing it and passing it through an 80-mesh stainless steel rotary vibrating sieve, then placing the sieve under 5 times the volume of petroleum ether and heating it at 65°C for reflux extraction for 3 hours, taking out the residue, drying it, grinding it, and then using 20 times the concentration of 75% ethanol to reflux extract it at 80°C for 2 hours, and then drying and grinding the obtained residue again, adding 3 times the concentration of water to reflux extract twice, the first time heating reflux extraction at 65°C for 2 hours, and the second time heating reflux extraction at 60°C for 1 hour, standing and cooling, and then filtering, combining the extracts obtained after each extraction, concentrating it, adding 95% ethanol for alcohol precipitation to obtain a flocculent precipitate, and freeze-drying the precipitate into a powder, which is the Chinese jujube seed extract;

[0033] The extraction method of the seabuckthorn extract is as follows:

[0034] (1) Dry fresh sea buckthorn in an oven at 60° C. for 24 h, crush and sieve through a 40-mesh sieve to obtain sea buckthorn powder, and then defatting the sea buckthorn powder, the specific steps of which are: mix the sea buckthorn powder with petroleum ether in a solid-liquid ratio of 1:3 (g / mL), heat and reflux extract twice, the first time at 65° C. for 2 hours, and the second time at 65° C. for 1 hour, stand and cool, pour out the oil layer, use a rotary evaporator at 55° C. to recover the petroleum ether under reduced pressure, then place in a fume hood and evaporate to constant weight to obtain defatted sea buckthorn powder;

[0035] (2) Adding defatted seabuckthorn powder to a 75% ethanol solution at a solid-liquid ratio of 1:30 (g / mL), then adding cyclodextrin and 1-methyl-3-n-octylimidazole bromide, wherein the amount of cyclodextrin and 1-methyl-3-n-octylimidazole bromide added is 8% of the total amount of defatted seabuckthorn powder, respectively, and mixing them evenly. Ultrasonic extraction is performed at a temperature of 65° C. and a power of 200 W for 10 minutes to obtain a seabuckthorn extract.

[0036] Example 2

[0037] The difference from Example 1 is that the raw material composition of the lipid-lowering composition is as follows: 160 parts of jujube seed extract, 50 parts of sea buckthorn extract, 100 parts of theanine, 80 parts of γ-aminobutyric acid, 80 parts of phosphatidylserine, 32 parts of microcrystalline cellulose, 18 parts of sorbitol and 8 parts of magnesium stearate.

[0038] Example 3

[0039] The difference from Example 1 is that the raw material composition of the lipid-lowering composition is as follows: 250 parts of Ziziphus jujuba seed extract, 160 parts of Hippophae rhamnoides extract, 150 parts of theanine, 100 parts of γ-aminobutyric acid, 100 parts of phosphatidylserine, 55 parts of microcrystalline cellulose, 30 parts of sorbitol and 15 parts of magnesium stearate.

[0040] Comparative Example 1

[0041] Commercially available atorvastatin calcium was used as comparative example 1.

[0042] Comparative Example 2

[0043] The difference from Example 1 is that no Ziziphus jujuba seed extract is added, and the rest of the contents are consistent with Example 1.

[0044] Comparative Example 3

[0045] The difference from Example 1 is that no seabuckthorn extract is added, and the rest of the contents are consistent with Example 1.

[0046] Comparative Example 4

[0047] The difference from Example 1 is that no cyclodextrin is added during the extraction of seabuckthorn extract, and the rest of the contents are consistent with Example 1.

[0048] Lipid-lowering efficacy test:

[0049] 1. Experimental materials:

[0050] The high-fat feed consists of 82.3% ordinary feed, 10% lard, 2.5% cholesterol, 0.2% sodium cholate, and 5% sucrose. The raw materials of the ordinary feed are 30% corn flour, 25% standard flour, 20% bran, 10% soybean meal, 10% fish meal, 2% yeast powder, 1% salt, 1% cod liver oil, 0.5% vitamin additives, and 0.5% trace element additives.

[0051] 2. Construction method: 90 clean-grade inbred SD male rats were selected under the same conditions, with free drinking water, food intake, natural light, and no adverse factors. After one week of adaptive feeding, they were randomly divided into two groups, 80 in the first group and 10 in the second group. The first group was fed with high-fat feed, and the second group was fed with ordinary feed. After 4 consecutive weeks of feeding, the blood lipids of the rats were measured, and the rats with serum total cholesterol content higher than 3mmol / l were considered to have successfully constructed a hyperlipidemia rat model.

[0052] 3. Build results:

[0053] The total serum cholesterol levels of the 80 rats in the first group were all higher than 5mmol / l, while the second group showed no symptoms of hyperlipidemia.

[0054] 4. Experimental method: The 80 rats in the first group with successful hyperlipidemia model were randomly divided into eight groups, namely, group A, group B, group C, group D, group E, group F, group G, and group H. Group A was the hyperlipidemia model control group, and the other groups corresponded to the lipid-lowering products of Examples 1-3 and Comparative Examples 1-4, respectively. The dosage was 10 mg / kg body weight / day, and the drug was dissolved in water and then administered by gavage. The control group was fed with an equal volume of purified water, and the blood lipid status of the rats was measured after continuous administration for 18 days (normal feeding with ordinary feed during the administration period).

[0055] 5. The results of medication are shown in Table 1:

[0056] Table 1 Effects on blood lipids in hyperlipidemic rats

[0057] Group TC(mmol / L) TG (mmol / L) Model control group 4.03±0.35 0.98±0.21 Example 1 3.45±0.26** 0.59±0.18 Example 2 3.65±0.41* 0.62±0.26** Example 3 3.53±0.12** 0.61±0.48* Comparative Example 1 3.68±0.55 0.69±0.37* Comparative Example 2 3.93±0.43* 0.78.±0.35* Comparative Example 3 3.99±0.45** 0.83±0.41 Comparative Example 4 3.85±0.26 0.81±0.33*

[0058] In Table 1, compared with the model group, *P<0.05, **P<0.01.

[0059] As shown in Table 1, the lipid-lowering compositions provided by Examples 1-3 of the present invention have the effect of reducing total cholesterol and triglycerides in mice, and their lipid-lowering effects are comparable to or even better than those of commercially available atorvastatin calcium. The lipid-lowering effects of the lipid-lowering compositions of Comparative Examples 2-4 are significantly inferior to those of Examples 1-3.

[0060] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A method for preparing a lipid-lowering composition containing a spiny jujube seed extract, characterized in that: The following steps are involved: After evenly mixing the jujube seed extract, seabuckthorn extract, theanine, γ-aminobutyric acid and phosphatidylserine, microcrystalline cellulose, sorbitol and magnesium stearate are added, mixed and granulated to obtain the product.

2. The method for preparing the lipid-lowering composition containing the spiny jujube seed extract according to claim 1, characterized in that: The extraction method of the Chinese jujube seed extract comprises the following steps: drying the Chinese jujube seed at 60-80°C for 18-24h, crushing and sieving, then placing the sieved material in 3-5 times the volume of petroleum ether and heating and refluxing extraction at 60-65°C for 2-3h, taking out the residue, drying, grinding and crushing it, and then refluxing extraction with 15-20 times the concentration of 75% ethanol at 60-80°C for 1-2h, drying, grinding and crushing the obtained residue again, adding 2-3 times the concentration of water and refluxing extraction twice, the first time is heated and refluxed at 65°C for 2h, and the second time is heated and refluxed at 60°C for 1h, standing and cooling, and then filtering, combining the extracts obtained after each extraction, concentrating, adding 95% ethanol for alcohol precipitation to obtain flocculent precipitates, and freeze-drying the precipitates into powder, which is the Chinese jujube seed extract.

3. The method for preparing the lipid-lowering composition containing the spiny jujube seed extract according to claim 1, characterized in that: The extraction method of the seabuckthorn extract comprises the following steps: (1) drying fresh sea buckthorn at 60-80° C. for 18-24 hours, crushing and sieving to obtain sea buckthorn powder, then mixing the sea buckthorn powder with petroleum ether at a solid-liquid ratio of 1:3, heating and refluxing extraction twice, the first heating and refluxing at 65° C. for 2 hours, the second heating and refluxing at 65° C. for 1 hour, standing and cooling, pouring out the oil layer, and recovering the petroleum ether by using a rotary evaporator at 55° C. under reduced pressure, then placing in a fume hood and evaporating to constant weight to obtain defatted sea buckthorn powder; (2) adding defatted seabuckthorn powder to 75-95% ethanol solution at a solid-liquid ratio of 1:20-30, then adding cyclodextrin and 1-methyl-3-n-octylimidazole bromide, mixing evenly, and performing ultrasonic extraction for 10-20 minutes at a temperature of 55-65° C. to obtain a seabuckthorn extract.

4. The method for preparing the lipid-lowering composition containing the spiny jujube seed extract according to claim 1, characterized in that: The lipid-lowering composition comprises the following components in parts by weight: 160-250 parts of spinosa jujube seed extract, 50-160 parts of seabuckthorn extract, 100-150 parts of theanine, 80-100 parts of γ-aminobutyric acid, 80-100 parts of phosphatidylserine, 32-55 parts of microcrystalline cellulose, 18-30 parts of sorbitol and 8-15 parts of magnesium stearate.

5. The method for preparing the lipid-lowering composition containing the spiny jujube seed extract according to claim 1, characterized in that: The blood lipid lowering composition comprises the following components in parts by weight: 180-230 parts of spinosa jujube seed extract, 80-100 parts of sea buckthorn extract, 120-130 parts of theanine, 90-95 parts of gamma-aminobutyric acid, 90-95 parts of phosphatidylserine, 45-50 parts of microcrystalline cellulose, 23-28 parts of sorbitol and 10-12 parts of magnesium stearate.

6. The method for preparing the lipid-lowering composition containing the spiny jujube seed extract according to claim 1, characterized in that: The lipid-lowering composition comprises the following components in parts by weight: 200 parts of jujube seed extract, 90 parts of seabuckthorn extract, 125 parts of theanine, 93 parts of γ-aminobutyric acid, 93 parts of phosphatidylserine, 48 parts of microcrystalline cellulose, 25 parts of sorbitol and 11 parts of magnesium stearate.

7. A lipid-lowering composition containing a spiny jujube seed extract, characterized in that: The lipid-lowering composition containing the spiny jujube seed extract is prepared by the method according to any one of claims 1 to 6.

8. The lipid-lowering composition containing the Semen Ziziphi Spinosae extract according to claim 7, characterized in that: The dosage form of the lipid-lowering composition is selected from various pharmaceutically acceptable dosage forms.

9. Use of the lipid-lowering composition containing the extract of Ziziphus jujuba seed prepared by the method of any one of claims 1 to 6 or the lipid-lowering composition containing the extract of Ziziphus jujuba seed according to claim 7 in the production and treatment of hyperlipidemia drugs.