Traditional Chinese medicine preparation for treating ichthyosis and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine preparation for treating ichthyosis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following raw materials by weight according to the principle of monarch, minister, assistant and guide: 10-35g of salvia miltiorrhiza, 10-15g of rhizoma smilacis glabrae, 10-40g of radix sophorae flavescentis, 10-40g of cortex dictamni, 10-40g of radix paeoniae rubra, 10-30g of rehmannia, 10-15g of radix pseudostellariae, 10-40g of bighead atractylodes rhizome, 10-15g of glossy privet fruit, 20-60g of motherwort, 10-15g of radix clematidis and 10-40g of honeysuckle stem. The traditional Chinese medicine has the effects of softening hardness to dissipate stagnation, dispelling wind, moistening dryness, relieving itching, promoting blood circulation to remove blood stasis, dredging collaterals, tonifying kidney, nourishing blood, tonifying qi and blood, nourishing blood, moistening skin, nourishing yin, promoting salivation and the like, and is specially used for treating ichthyosis. The medicine is prepared into powder, external use is facilitated, the treatment operation method is simple, and the medicine is suitable for industrial production and application.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine preparation for treating ichthyosis and a preparation method thereof. Background Art

[0002] Ichthyosis Vulgaris is a common hereditary skin disease that usually begins to show symptoms in childhood. The main feature of this disease is that the skin becomes abnormally dry, rough, and has a scaly stratum corneum on the surface. Ichthyosis usually causes itching and discomfort, and in severe cases may cause cracking, bleeding and infection of the skin.

[0003] TCM believes that the onset of ichthyosis is related to the body's congenital deficiency of blood, spleen deficiency and weak blood, and insufficient lung qi, which leads to blood deficiency, wind dryness, and skin malnutrition. TCM's syndrome differentiation and treatment system is based on the patient's specific symptoms and constitution, as well as the syndrome differentiation of the spleen, lungs, kidneys and other internal organs. The treatment plan for ichthyosis mainly uses external treatment methods such as fumigation to treat skin diseases, which was recorded as early as the Warring States Period. With the development of the times and scientific research, great progress has been made in diagnosis and treatment technology. TCM believes that congenital deficiency can be gradually improved through acquired conditioning, and that internal and external treatment can be achieved by adjusting the balance of qi, blood, body fluids and internal organs, so that the skin can return to normal. Summary of the invention

[0004] In view of this, the present invention proposes a Chinese medicine preparation for treating ichthyosis and a preparation method thereof, wherein the Chinese medicines are combined according to the principle of monarch, minister, assistant and envoy, and the efficacy is exerted through thermal action to achieve the purposes of softening and dispersing nodules, activating blood circulation and promoting muscle growth, restoring the functions of skin hair follicles, sweat glands and sebaceous glands, and inhibiting the regeneration of scales.

[0005] Based on the above purpose, in the first aspect, the present invention provides a traditional Chinese medicine preparation for treating ichthyosis, wherein the traditional Chinese medicine preparation for treating ichthyosis is prepared by adding or subtracting the following raw materials by weight according to the principle of monarch, minister, assistant and envoy:

[0006] Salvia miltiorrhiza 10-35g, Smilax glabra 10-15g, Sophora flavescens 10-40g, Dictamni cortex 10-40g, Paeonia lactiflora 10-40g, Rehmannia glutinosa 10-30g, Pseudostellaria pseudoginseng 10-15g, Atractylodes macrocephala 10-40g, Ligustrum lucidum 10-15g, Leonurus japonicus 20-60g, Clematidis 10-15g, Honeysuckle 10-40g.

[0007] As a further solution of the present invention, the salvia miltiorrhiza, sophora flavescens, diffusa cortex, red peony root, rehmannia root, and motherwort are monarch drugs, Pseudostellaria pseudoginseng, Atractylodes macrocephala, and Ligustrum lucidum are ministerial drugs, Clematidis is an adjuvant drug, and the rest are guiding drugs, which conforms to the syndrome differentiation and treatment system of traditional Chinese medicine.

[0008] As a further embodiment of the present invention, the Chinese medicine preparation does not contain any auxiliary materials, and only includes salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, red peony root, rehmannia root, pseudostellaria, atractylodes, glossy privet fruit, motherwort, clematis and honeysuckle ingredients.

[0009] In a second aspect, the present invention further provides a method for preparing a Chinese medicine preparation for treating ichthyosis, comprising the following steps:

[0010] The components of the Chinese medicine preparation, namely, salvia miltiorrhiza, smilax glabra, sophora flavescens, radix difficile, red peony root, rehmannia root, pseudoginseng, atractylodes macrocephala, fructus ligustris, motherwort, clematis root and honeysuckle vine, are respectively crushed into powders of 60-80 mesh;

[0011] Mix the powders of Salvia miltiorrhiza, Smilax glabra, Sophora flavescens, Dictamni cortex, Paeonia lactiflora, Rehmannia glutinosa, Pseudostellaria baicalensis, Atractylodes macrocephala, Fructus Ligustri Lucidi, Leonurus japonicus, Clematis chinensis and Honeysuckle vine and put them into a container for later use.

[0012] As a further embodiment of the present invention, the method for preparing the Chinese medicine preparation further comprises the following steps:

[0013] Process the salvia miltiorrhiza, sophora flavescens, dactylic bark, red peony root, rehmannia root, and motherwort, add rice wine, simmer for a while, then fry until dry, let cool, and sieve out the debris; fry the other part with salt;

[0014] Process the red peony root, add yellow wine, simmer for a while, heat until it turns slightly yellow, take it out and let it cool, and sieve out the debris;

[0015] Process the Ligustrum lucidum fruit, mix it with rice wine, steam it until the wine is absorbed and it becomes dark and moist, then dry it.

[0016] As a further embodiment of the present invention, the Chinese medicine preparation is used to treat ichthyosis, and the external treatment method of the Chinese medicine preparation includes twice a day, one dose each time, and adjusting the treatment time and temperature according to the age and constitution of the patient; for mild and moderate patients, the treatment cycle is 7 to 14 days, and for severe patients, the treatment cycle is 28-56 days.

[0017] As a further embodiment of the present invention, the therapeutic effects of the Chinese medicine preparation include softening and dispersing nodules, promoting blood circulation and promoting muscle growth, restoring the functions of skin hair follicles, sweat glands and sebaceous glands, and inhibiting the regeneration of scales.

[0018] As a further scheme of the present invention, the preparation method of the traditional Chinese medicine preparation also includes processing Danshen, Smilax glabra, Sophora flavescens, Dictamni cortex, Paeonia lactiflora, Rehmannia glutinosa, Pseudostellaria baicalensis, Atractylodes macrocephala, Fructus Ligustri Lucidi, Leonurus japonicus, Clematis chinensis and Lonicera japonica of the traditional Chinese medicine preparation into powder for external use, and the operation method is simple and suitable for industrial production and application.

[0019] As a further solution of the present invention, the cure rate of the Chinese medicine preparation reaches 90%, and the total effective rate is 100%.

[0020] As a further solution of the present invention, the preparation method and treatment method of the Chinese medicine preparation conform to ZY / T00.8-94 "Standards for the Efficacy of Traditional Chinese Medicine Dermatological Diseases" issued by the State Administration of Traditional Chinese Medicine in 1994.

[0021] As a further solution of the present invention, the formula of the Chinese medicine preparation is individually adjusted according to the patient's physical constitution to improve the therapeutic effect.

[0022] As a further embodiment of the present invention, the method for preparing the Chinese medicine preparation also includes loading the Chinese medicine ingredients into a container, and then subjecting the container to thermal treatment to exert the medicinal effect. According to the patient's TCM physical signs, the temperature is adjusted to 36°-45°C and the duration is adjusted to 20-45 minutes.

[0023] As a further embodiment of the present invention, the method for preparing the Chinese medicine preparation further includes packing the Chinese medicine powder into a non-woven medicine bag to facilitate external use and maintain the integrity and ease of use of the medicine.

[0024] As a further embodiment of the present invention, in the method for preparing the Chinese medicine preparation, the steps of mixing the Chinese medicine powder and loading it into the container are carried out according to the principle of monarch, minister, assistant and envoy in the TCM syndrome differentiation and treatment system to ensure the comprehensive efficacy of the medicine.

[0025] Compared with the prior art, the Chinese medicine preparation for treating ichthyosis and the preparation method thereof proposed by the present invention have the following beneficial effects:

[0026] 1. Comprehensive TCM Syndrome Differentiation and Treatment: The TCM preparation and preparation method of the present invention are based on the TCM Syndrome Differentiation and Treatment system, fully consider the patient's constitution and condition, and carry out TCM compatibility according to the principle of monarch, minister, assistant and envoy to ensure the comprehensive efficacy of the medicine. This comprehensive treatment method can better meet the needs of different patients and improve the pertinence and effectiveness of the treatment.

[0027] 2. Multiple effects combined: The Chinese medicine preparation of the present invention contains multiple natural herbal ingredients in its formula, such as salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, red peony root, rehmannia root, pseudoginseng, atractylodes macrocephala, glossy privet fruit, motherwort, clematis root, honeysuckle vine, etc. These ingredients have multiple effects such as dispelling wind, moistening dryness and relieving itching, promoting blood circulation and removing blood stasis, promoting collaterals, nourishing kidney and blood, replenishing qi and blood, nourishing blood and moisturizing skin, nourishing yin and promoting body fluid, etc. Therefore, patients can benefit from multiple Chinese medicine ingredients in one treatment and accelerate the recovery process.

[0028] 3. Convenient external use: The Chinese medicine preparation of the present invention is prepared in the form of powder, which is very convenient for external use. The Chinese medicine powder is packed into a non-woven medicine bag, and the patient only needs to put the medicine bag into the treatment device or instrument, and then take the treatment according to the doctor's advice. This external use method avoids the discomfort or side effects that may be caused by oral medication.

[0029] 4. High cure rate and total effective rate: Clinical trial results show that the Chinese medicine preparation of the present invention and its preparation method have a cure rate of up to 90% and a total effective rate of 100% for ichthyosis, which indicates that it has a significant effect in treating ichthyosis and can quickly improve the symptoms of patients.

[0030] 5. Safety: During the trial, all patients did not experience any adverse reactions when using the Chinese medicine preparation of the present invention, which shows that the preparation is safe and reliable and suitable for a wide range of patients, including children and the elderly.

[0031] 6. Restore skin function: The Chinese medicine preparation of the present invention helps to restore the functions of the hair follicles, sweat glands and sebaceous glands of the skin by softening and dispersing lumps, activating blood circulation and promoting muscle growth. This can not only treat the symptoms of ichthyosis, but also help to improve the quality and appearance of the skin.

[0032] 7. Inhibit recurrence: The treatment method of the present invention can effectively inhibit the recurrence of ichthyosis. Through multiple effects such as nourishing the kidney and liver, regulating qi and blood, dispelling wind and relieving itching, the possibility of recurrence of the disease is reduced, so that patients benefit in the long term.

[0033] These and other aspects of the present application will be more concise and understandable in the following description of the embodiments. It should be understood that the above general description and the following detailed description are only exemplary and explanatory and cannot limit the present application. DETAILED DESCRIPTION

[0034] Below, the present application is further described in conjunction with specific implementation methods. It should be noted that, under the premise of no conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0035] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the embodiments of the present invention are further described in detail in conjunction with specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0036] It should be noted that all expressions using "first" and "second" in the embodiments of the present invention are intended to distinguish two non-identical entities or non-identical parameters with the same name. It can be seen that "first" and "second" are only for the convenience of expression and should not be understood as limitations on the embodiments of the present invention. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, other steps or units inherent to a process, method, device, product or equipment that includes a series of steps or units.

[0037] The technical solutions in the embodiments of the present application are described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0038] Some embodiments of the present application are described in detail below. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other.

[0039] TCM believes that ichthyosis is caused by congenital deficiency of essence and blood, spleen deficiency and blood weakness, and insufficient lung qi, which leads to blood deficiency, wind dryness, and skin malnutrition. According to the diagnosis of viscera and organs, the incidence of ichthyosis is related to the kidney, spleen, and lung. Spleen deficiency and blood weakness, insufficient lung qi, will lead to blood stasis, poor meridians, malnutrition of the body and skin, and skin scaly. Dysfunction of the viscera and wind, dryness, stasis, and deficiency will lead to malnutrition of the skin and skin scaly, forming fish-like skin lesions. When the kidney essence is weak, the transformation process of the body's essence, qi, and body fluids is affected, the skin is not nourished by the menstrual blood, and the skin scaly, and the essence and blood cannot moisten, which will turn into dryness and wind over time.

[0040] The traditional Chinese medicine external treatment method of fumigation to treat skin diseases can be found in records as early as the Warring States Period. With the development of the times and scientific research, great progress has been made in diagnosis and treatment technology. Traditional Chinese medicine believes that congenital deficiencies can be gradually improved through acquired conditioning, and that by adjusting the balance of qi, blood, body fluids and internal organs, internal and external treatment can be achieved, so that the skin can return to normal.

[0041] The present invention aims to provide a Chinese medicine preparation for treating ichthyosis and a preparation method thereof, wherein the Chinese medicines are combined according to the principle of monarch, minister, assistant and envoy, and the efficacy is exerted through thermal action, so as to achieve the purposes of softening and dispersing nodules, activating blood circulation and promoting muscle growth, restoring the functions of skin hair follicles, sweat glands and sebaceous glands, and inhibiting the regeneration of squama.

[0042] In an embodiment of the present invention, the present invention provides a traditional Chinese medicine preparation for treating ichthyosis, which is prepared by adding and subtracting the following raw materials by weight according to the principle of monarch, minister, assistant and envoy: 10-35g of Salvia miltiorrhiza, 10-15g of Smilax glabra, 10-40g of Sophora flavescens, 10-40g of Dictamni, 10-40g of Paeonia lactiflora, 10-30g of Rehmannia glutinosa, 10-15g of Pseudostellaria pseudoginseng, 10-40g of Atractylodes macrocephala, 10-15g of Ligustrum lucidum, 20-60g of Leonurus japonicus, 10-15g of Clematidis, and 10-40g of Honeysuckle.

[0043] Among them, the salvia miltiorrhiza, sophora flavescens, diffusa cortex, red peony root, rehmannia root, and motherwort are the main medicines, Pseudostellaria pseudoginseng, Atractylodes macrocephala, and Ligustrum lucidum are the ministerial medicines, Clematidis is the adjuvant medicine, and the rest are guiding medicines, which are in line with the system of syndrome differentiation and treatment in traditional Chinese medicine.

[0044] The Chinese medicine preparation does not contain any auxiliary materials, and only includes salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, red peony root, rehmannia root, pseudostellaria, atractylodes, glossy privet fruit, motherwort, clematis and honeysuckle vine ingredients.

[0045] In this embodiment, the Chinese medicine preparation does not add any auxiliary materials. The medicinal materials are placed in a 60-90g container and heated by the thermal effect of the equipment to exert the medicinal effects, soften and disperse nodules, promote blood circulation and regenerate muscles, restore the functions of the three major glands of hair follicles, sweat glands, and sebaceous glands, and ultimately inhibit the regeneration of scales.

[0046] In the present invention, the above-mentioned raw materials have the following functions:

[0047] Danshen is a blood-activating and stasis-removing medicine, which is the dried root and rhizome of the plant Danshen of the Labiatae family. Danshen is bitter in nature, slightly cold, and enters the heart and liver meridians. Danshen is bitter and can dissipate, slightly cold and can clear, and enters the heart and liver meridians. It can not only activate blood circulation and remove blood stasis, promote menstruation and relieve pain, but also refresh and cool blood and eliminate restlessness and eliminate carbuncle. It is mainly used to treat blood stasis, blood heat, heat disturbing the mind, and heat-toxic sores, carbuncle, swelling and pain. The Chinese medicine preparation of the present invention contains quinone components, protocatechuic aldehyde, protocatechuic acid, lactic acid, vitamin E and other components, and has the functions of promoting blood circulation and removing blood stasis, promoting menstruation and relieving pain, clearing the heart and eliminating restlessness, cooling blood and eliminating carbuncle.

[0048] Smilax glabra is a heat-clearing medicine, which is the dried rhizome of Smilax glabra, a plant of the Liliaceae family. Smilax glabra is sweet, light and flat in nature. It enters the liver and stomach meridians. The Chinese medicine preparation of the present invention has the effects of detoxification, dehumidification and joint unblocking, and is used to treat carbuncle, scrofula, scabies and the like.

[0049] Sophora flavescens is a heat-clearing medicine. It is the dried root of the short-lived plant Sophora flavescens. It is dug in spring and autumn. The root head and small branches are removed, washed, and dried, or sliced ​​and dried while fresh. Sophora flavescens is bitter and cold in nature. It enters the heart, liver, stomach, large intestine, and bladder meridians. Sophora flavescens is very bitter and cold, pure yin, clears dryness and descends, and has a strong medicinal effect. It mainly enters the heart, liver, and meridians, and also enters the large intestine and bladder meridians. It can clear heat and dry dampness, so that damp heat is resolved from the inside; it is also a diuretic, guiding damp heat and fire poison out of the urine; it also dispels wind and kills insects to stop itching. The effect is similar to that of Coptis chinensis, but the effect is weaker. It is especially good at clearing heart fire and removing damp heat in the middle and lower jiao. It is suitable for all sores, rashes, itching and pain caused by damp heat, wind, and insects, especially for damp heat itching and pain, vaginal itching and leucorrhea with wind and insects.

[0050] The Chinese medicine preparation of the present invention contains alkaloids such as matrine, oxymatrine, isomatrine, sophoracarpine, isosophoracarpine, oxysophocarpine, and sophoramine. In addition, it also contains flavonoid compounds such as matrine, neomatrine, matrine, and isomatrine. It has the effects of clearing away heat and dampness, removing parasites, and promoting diuresis.

[0051] Dictamni is a heat-clearing medicine, which is the dried root bark of Dictamni of Rutaceae. The Chinese medicine preparation of the present invention is bitter, dry and purgative, and can clear away coldness. It enters the spleen and stomach meridians, as well as the bladder and small intestine meridians. It is good at clearing away heat and detoxifying, drying dampness, promoting dampness, dispelling wind and relieving jaundice, relieving itching and curing numbness, and is "the key medicine for all jaundice and wind arthralgia". It can be used for all syndromes caused by the combination of heat, dampness and wind, and is commonly used to treat damp-heat sores, scabies, damp-heat jaundice and rheumatic heat arthralgia.

[0052] The traditional Chinese medicine preparation of the present invention mainly contains alkaloids such as dactyline and dactyline and limonoid compounds such as kaempferol, kaempferol and kaempferol acid.

[0053] Red peony root is a heat-clearing medicine. It is the dried root of the plant Paeonia lactiflora or Sichuan red peony root of the family Paeonia lactiflora. It is collected in spring and autumn. Red peony root is bitter and can dissipate, slightly cold and can clear, and specifically enters the liver meridian, cooling and dispersing blood stasis. It can clear liver fire and cool blood, and promote blood circulation and remove blood stasis. It combines cooling blood heat, clearing liver fire, and dispersing blood stasis. It can be used for blood heat, blood stasis, liver fire, whether single or combined. It is especially suitable for pain caused by blood heat and blood stasis, blood stasis and heat, or liver fire and blood stasis.

[0054] The Chinese medicine preparation of the present invention contains monoterpene glycosides such as paeoniflorin, hydroxypeoniflorin, benzoylpeoniflorin, benzoylhydroxypeoniflorin and other monoterpene glycosides and polyphenol compounds such as gallic acid glucose and paeonol, and has the effects of clearing away heat, cooling blood, dispersing blood stasis and relieving pain.

[0055] Rehmannia root is a heat-clearing medicine. It is the dried root of Rehmannia root of the Scrophulariaceae family. Rehmannia root is sweet, bitter and cold in nature. It enters the heart, liver and meridians. Rehmannia root is sweeter than bitter, moist and sweet, bitter and cold, and clears away heat and cools the blood, relieves restlessness and stops bleeding; it enters the kidney meridian, nourishes yin and produces body fluid, lubricates the large intestine, quenches thirst and relieves constipation. It can eliminate evil and strengthen the body, and can be used for blood heat, yin deficiency with heat, yin and blood deficiency, and dryness of body fluid and intestines. Heat: It is most suitable for those with excessive yin injury.

[0056] The Chinese medicine preparation of the present invention mainly contains cyclic terpene glycosides such as catalpol, dihydroxy catalpol, acetyl catalpol, rehmannia glycoside, aucubin, milite glycoside, monomilite glycoside, dehydroxy gardenia glycoside, scutellaria glycoside and phenylethanoid glycosides such as verbascoside. In addition, it also contains β-sitosterol, various amino acids and sugars. It has the functions of clearing away heat, cooling blood, nourishing yin and promoting body fluid.

[0057] Pseudostellariae Radix is ​​a tonic medicine, which is the dried root of the plant Pseudostellariae Radix. Pseudostellariae Radix is ​​mild and slightly cool, sweet and slightly bitter, and can purge. It enters the spleen and lung meridians, and can tonify the middle and clear the body. Its function is similar to that of ginseng, but its medicinal power is much weaker. It can replenish qi and produce body fluid, and is mostly used for mild symptoms of both qi and body fluid damage, or for those with heat.

[0058] The Chinese medicine preparation of the present invention contains multiple ingredients such as amino acids, polysaccharides, flavonoids, tannins, coumarin, sterols, triterpenes and multiple trace elements, etc. The Chinese medicine preparation of the present invention has the effects of invigorating qi, strengthening spleen, promoting body fluid and moistening lungs.

[0059] Atractylodes macrocephala is a tonic medicine, which is the dried rhizome of Atractylodes macrocephala of the Asteraceae family. Atractylodes macrocephala is bitter, sweet and warm in nature. It enters the spleen and stomach meridians. Atractylodes macrocephala is sweet, nourishing, penetrating and beneficial, bitter, warm and dry, enters the spleen and meridians, and mainly warms and nourishes the body, and can also remove dampness. It is good at replenishing qi and strengthening the spleen, drying dampness and promoting diuresis, and stopping sweating. It treats spleen and stomach qi deficiency, spleen deficiency edema, phlegm and fluid retention, and spontaneous sweating due to superficial deficiency.

[0060] The traditional Chinese medicine preparation of the present invention contains volatile oils such as atractylone, atractylol, atractylether, juniper brain, atractylolactone, lactone compounds such as atractylolactone I-IV and bis-atractylolactone, and also contains fructose, inulin, atractylodes polysaccharide, various amino acids, atractylodes triol and vitamin A, and has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, and stopping sweating.

[0061] Ligustrum lucidum is a tonic medicine, which is the dried mature fruit of Ligustrum lucidum, a plant of the Oleaceae family. It is sweet, bitter and cool. It enters the liver and kidney meridians. Ligustrum lucidum is sweet, tonic, cool and refreshing, bitter and laxative without being greasy, and enters the liver and kidney meridians. It is a cool tonic. It is good at nourishing the yin of the liver and kidney, and clears away heat and improves eyesight. Ligustrum lucidum contains triterpenoid components, iridoid glycoside components, flavonoid components, fatty acid components, volatile oils, polysaccharides and other components.

[0062] Motherwort is a blood-activating and menstruation-regulating medicine, which is the fresh or dried aerial part of the Labiatae plant Motherwort. Motherwort is bitter, pungent, slightly cold, and enters the liver, pericardium, and bladder meridians. Motherwort is pungent, dispersing, bitter, and slightly cold, and mainly enters the heart and liver meridians, and also enters the bladder meridian. It can activate blood circulation and remove blood stasis, treat various diseases caused by blood stasis, especially treat various diseases caused by blood stasis and menstruation, and is a good medicine for regulating menstruation in gynecology; it can also promote diuresis and reduce swelling, clear away heat and detoxify, treat edema caused by water stasis and sores and rashes caused by heat and toxicity, and is suitable for those with blood heat and blood stasis, edema, or sores and swelling with blood stasis. The Chinese medicine preparation of the present invention contains ingredients such as alkaloids, diterpenes, and volatile oils, and has the functions of promoting blood circulation and menstruation, promoting diuresis and reducing swelling, and clearing away heat and detoxifying.

[0063] Clematis is a rheumatism-relieving drug. It is the dried root and rhizome of Clematis, Clematis chinensis or Clematis nigra. Clematis chinensis is pungent, salty and warm in nature. It enters the bladder meridian. Clematis chinensis is pungent, dispersing, salty, soft, warm and unblocked. It enters the bladder meridian (or the twelve meridians), is good at running around, and has strong and fast effects. It is good at removing rheumatism, unblocking meridians, and eliminating phlegm or softening hard masses. It is most suitable for rheumatic arthralgia, cramps and numbness, flexion and extension difficulties and cold, and can treat phlegm and fluid accumulation. Clematis chinensis contains protooleanolic acid, ivy saponin, protoanone palmitic acid and other ingredients. It has the effect of removing rheumatism and unblocking meridians.

[0064] Honeysuckle is a heat-clearing medicine, which is the dried stems and branches of the honeysuckle plant of the Caprifoliaceae family. The best ones are those with red skin, tender texture and leaves. Honeysuckle tastes sweet, is cold in nature, and enters the lung and stomach meridians. Honeysuckle has the effects of clearing away heat and detoxifying, dispersing wind and unblocking meridians. It is mainly used for fever caused by febrile diseases, heat-toxic bloody diarrhea, carbuncle, sore, rheumatism, heat arthralgia, and red, swollen, hot and painful joints.

[0065] It mainly contains organic acids such as chlorogenic acid and isochlorogenic acid, flavonoids such as quercetin and luteolin, and saponins such as honeysuckle glycoside A.

[0066] In an embodiment of the present invention, a method for preparing a Chinese medicine preparation for treating ichthyosis is also provided, comprising the following steps: taking each raw material according to the weight fraction, taking each raw material according to the prescription compatibility, first drying salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, rehmannia root, pseudostellaria, atractylodes macrocephala, glossy privet fruit, motherwort, clematis root, and honeysuckle vine, using ultrafine grinding technology to grind to 60-80 mesh, and the powder is put into a container for standby use, and then according to each person's physical constitution, medicines are prepared, and then the medicines are placed in a treatment device, and the medicines are fully exerted through thermal fumigation to achieve the purpose of softening and dispersing nodules, activating blood circulation and promoting muscle regeneration, restoring the functions of hair follicles, sebaceous glands, and sweat glands, and inhibiting the regeneration of scales.

[0067] In this embodiment, the salvia miltiorrhiza slices are added with a certain amount of rice wine and mixed evenly (10 kg of rice wine is used for every 100 kg of salvia miltiorrhiza), and slightly simmered until the wine is completely absorbed, and then placed in a frying container, heated, fried until dry, taken out and cooled, and the debris is sieved out.

[0068] Take red peony root slices, add rice wine and mix well (for every 100 kg of red peony root slices, use 12 kg of rice wine), simmer for a while, and after the wine is absorbed, put it in a preheated frying container, heat, fry until slightly yellow, take out and let cool, and sieve out the debris.

[0069] Take Ligustrum lucidum fruit and mix it with rice wine (for every 100kg of Ligustrum lucidum fruit, use 20kg of rice wine). After it is slightly steamed, place it in a sealed steamer and steam it in a water-proof pot or other suitable container until the wine is absorbed and the color is dark and moist. Then take it out and dry it.

[0070] Take clean Clematis segments or slices, add a certain amount of rice wine and mix well (for every 100kg, use 10kg of rice wine), simmer for a while, and after the wine is absorbed, put it in a frying container, heat it, fry it until it is dry, take it out, let it cool, and sieve out the debris.

[0071] The method for exerting the medicinal effect is: after the Chinese medicine is matched according to the physical constitution, the medicine bag is placed in the treatment device or instrument, and then the treatment device or equipment is heated, the duration is generally 20 to 45 minutes, and the temperature is controlled at about 36°.

[0072] The dosage of the Chinese medicine preparation for treating ichthyosis of the present invention is: external treatment, twice a day, one dose at a time; then each dose is placed in a special device for use, and the time and temperature are adjusted according to the patient's age and constitution. Usually, mild and moderate patients can take 7-14 days, and severe patients usually take 28-56 days.

[0073] The invention is based on the syndrome differentiation and treatment system of traditional Chinese medicine, the four properties and five flavors of traditional Chinese medicine, and the principle of monarch, minister, assistant and envoy compatibility. Twelve kinds of natural herbs, including salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, rehmannia root, pseudostellaria, atractylodes macrocephala, fructus ligustris, motherwort, clematis root and honeysuckle, are used together and have the effects of dispelling wind, moistening dryness and relieving itching, promoting blood circulation and removing blood stasis, unblocking meridians, invigorating the kidney and nourishing blood, replenishing both qi and blood, nourishing blood and moisturizing the skin, nourishing yin and promoting the production of body fluid, and the like, and is specially used for treating ichthyosis.

[0074] In the formula, salvia miltiorrhiza, sophora flavescens, radix difficile, red peony root, rehmannia root, motherwort, etc. are the main drugs, which have the effects of promoting blood circulation and promoting muscle growth, regulating spleen, liver and kidney qi and blood, etc.; Pseudostellaria baicalensis, Atractylodes macrocephala, and Ligustrum lucidum have the effects of softening and dispersing nodules, dispelling wind and relieving itching, and are the ministerial drugs, honeysuckle vine is the adjuvant drug, and the rest are the guiding drugs. The above drugs are supplemented with thermal fumigation equipment or instruments to achieve the purpose of softening and dispersing nodules, promoting blood circulation and promoting muscle growth, unblocking the functions of skin hair follicles, sweat glands, and sebaceous glands, achieving the purpose of recovery from ichthyosis, and inhibiting recurrence.

[0075] The present invention prepares the above medicine into powder, which is convenient for external use, and the treatment operation method is simple, and is suitable for industrial production and application.

[0076] The following examples are only used to further illustrate the present invention, but do not constitute any limitation to the present invention.

[0077] Example 1

[0078] The present embodiment provides a traditional Chinese medicine preparation for treating ichthyosis and a preparation method thereof. The traditional Chinese medicine preparation is composed of the following raw materials in total amount: 15g of salvia miltiorrhiza, 10g of smilax glabra, 10g of sophora flavescens, 10g of white peony root, 15g of red peony root, 30g of rehmannia root, 15g of pseudostellaria, 15g of atractylodes, 10g of glossy privet, 35g of motherwort, 10g of clematis, and 15g of honeysuckle.

[0079] In this embodiment, the preparation method of the Chinese medicine preparation for treating ichthyosis comprises the following steps:

[0080] (1) Take the raw materials according to their weight proportions, mix the red peony root with yellow wine and simmer for a while, and after the wine is completely absorbed, put them into a preheated frying container, heat with high heat, fry until slightly yellow, take them out and let them cool, sieve out the debris, and crush them using ultrafine powder technology for later use;

[0081] (2) removing the liquor from salvia miltiorrhiza, glossy privet fruit and clematis root, drying them in the sun and grinding them into powder using ultrafine powder technology for later use;

[0082] (3) The above raw materials are mixed with Smilax glabra, Sophora flavescens, Dictamni cortex, Rehmannia root, Pseudostellaria baicalensis, Atractylodes macrocephala, Leonurus japonicus, and Lonicera japonica vine according to the principles of traditional Chinese medicine, and then crushed to 60 mesh using ultrafine powder technology, placed in a non-woven medicine bag, and then heated in a treatment instrument or device for 35-45 minutes, with the temperature controlled at about 36°.

[0083] Dosage and administration: external treatment, twice a day, one dose at a time; then place each dose in a special device for use, and adjust the time and temperature according to the patient's age and constitution. Usually, 4-7 days are enough for mild and moderate patients, and 28 days are usually enough for severe cases.

[0084] Experimental example

[0085] 50 patients diagnosed with ichthyosis were selected and the technology in the embodiment of the present invention was applied externally. After the Chinese medicine was prepared according to the constitution, the medicine bag was placed in the treatment device or instrument, and then the treatment device or equipment was heated. The duration was generally 35-45 minutes, and the temperature was controlled at about 36°.

[0086] For external treatment, take one dose twice a day. Each dose should be placed in a dedicated device for use. The time and temperature should be adjusted according to the patient's age and constitution. Usually, it takes 4-7 days for mild and moderate patients, and 28 days for severe patients.

[0087] At present, the national scoring method for the diagnosis and efficacy standards of ichthyosis is ZY / T00.8-94 "Efficacy Standards for Traditional Chinese Medicine Dermatology Diseases" issued by the State Administration of Traditional Chinese Medicine in 1994.

[0088] Cure: Skin lesions completely disappear, or disappear by more than 95%;

[0089] Improvement: Skin lesions subsided by more than 50%;

[0090] Unhealed: Less than 50% of the lesions have subsided.

[0091]

[0092] As can be seen from the above table, the Chinese medicine prepared by the embodiment of the present invention and the system and operation method for treating ichthyosis have a cure rate of 90% and a total effective rate of 100%. No adverse reactions were observed in all patients during the medication period.

[0093] Typical Case 1

[0094] Zhu, male, 12 years old. The skin lesions resembled snake skin for 10 years, showing diffuse keratinization, with a family history. When the child was 2 years old, the skin was abnormally dry and snake patterns appeared. After the age of 8, the symptoms gradually worsened. The skin lesions on the face, neck and limbs were like fish scales, and the extension side was the most serious, accompanied by chapped skin. He had sought treatment in many places for several years, but no obvious effect was seen. According to the method of the embodiment, the skin lesions were significantly improved after one week, and no recurrence was found in the follow-up.

[0095] Typical Case 2

[0096] Bai, male, 23 years old. The skin of the whole body is dry and rough, like snake skin, with a medical history of 22 years. When he was 1 year old, snake-like skin patterns appeared faintly on his lower limbs, which gradually became obvious. When he was 3 years old, it was all over his limbs and trunk, and his lower limbs were particularly serious, like bitter bark. He went to many hospitals for a long time but was not cured. According to the method in the embodiment, the scales were completely detached after 7 days, the skin appearance was basically restored to normal, the skin function was better restored, the hair follicles were opened, the sweat glands were unblocked, and no recurrence was found in the follow-up.

[0097] Typical Case 3

[0098] Wang, female, 14 years old. The history of fish scale skin disease of both lower limbs is as long as 13 years. When she was half a year old, it was found that the skin of both lower limbs had a fish scale development trend. When she was 2 years old, the skin lesions became more serious. It was slightly relieved by oral vitamin C and external medication, and then repeated attacks became more severe. Due to the use of hormone drugs for external application, the skin is now mutated, like the skin that has been blistered for a long time, it is soft like leather, and there are no sweat gland pores. Many medical consultations have been fruitless. According to the method in the embodiment, squama is completely separated, skin function is basically restored, sweat glands are dredged, and sweating can be achieved. No recurrence is found in the follow-up.

[0099] Typical Case 4

[0100] Feng, male, 22 years old. After the patient was born, there was a thin film on the skin surface. After the skin was detached, it gradually became red. The parents did not pay attention to it. Then they found brown scales and gradually accumulated and thickened. When they went to the doctor, the whole body was covered with dark brown flaky thick and hard scales. The medical history was more than 20 years. He had sought medical treatment in many places across the country but could not control the development of his symptoms. According to the method in the embodiment, first large pieces of scales fell off, and then the fine scales were completely detached. After that, the skin function returned to normal, and no recurrence was found in the follow-up.

[0101] The Chinese medicine preparation for treating ichthyosis of the present invention and its preparation method are based on a variety of precious Chinese herbal medicines, and through careful prescription matching and preparation process, a Chinese medicine preparation with multiple effects is developed for treating ichthyosis. The Chinese medicine preparation of the present invention includes 12 different Chinese herbal medicines, each with a unique drug effect and mechanism of action. Among them, monarch drugs such as salvia miltiorrhiza, sophora flavescens, white fresh bark, red peony root, rehmannia root, motherwort, etc. have the effects of promoting blood circulation and promoting muscle growth, regulating spleen, liver and kidney qi and blood, etc., and ministerial drugs such as pseudoginseng, atractylodes macrocephala, and Ligustrum lucidum have the functions of softening and dispersing nodules, dispelling wind and relieving itching, and clematis root is used as an adjuvant to assist in exerting the effects of other herbs, so that they cooperate with each other to form an effective drug combination for treating ichthyosis.

[0102] In addition, the present invention also adopts a unique preparation method, prepares the Chinese medicine preparation into a powder form, and is equipped with a special treatment device or instrument to exert the efficacy through thermal fumigation. This unique preparation method ensures that the effective ingredients of the Chinese medicine can be fully released to treat ichthyosis to the greatest extent.

[0103] The Chinese medicine preparation of the present invention shows significant therapeutic effect in clinical application. After using the preparation, patients can not only improve the functions of hair follicles, sweat glands and sebaceous glands of damaged skin, but also effectively inhibit the recurrence of ichthyosis. The treatment results show that the total effective rate of the Chinese medicine preparation of the present invention reaches 100%, and no adverse reactions occur during the medication period, and the Chinese medicine preparation is suitable for patients of different age groups.

[0104] In summary, the Chinese medicine preparation for treating ichthyosis of the present invention and the preparation method thereof have significant advantages and curative effects, and provide a new, safe and effective Chinese medicine therapy for the treatment of ichthyosis. This invention is not only of great significance to the field of traditional Chinese medicine, but also provides a feasible method for industrial production, and is expected to be widely used in the treatment of ichthyosis patients in the future, improve their quality of life, and make a positive contribution to the inheritance and development of traditional Chinese medicine therapy.

[0105] The above are exemplary embodiments disclosed in the present invention, but it should be noted that various changes and modifications may be made without departing from the scope disclosed in the embodiments of the present invention as defined in the claims. The functions, steps and / or actions of the method claims according to the disclosed embodiments described herein do not need to be performed in any particular order. In addition, although the elements disclosed in the embodiments of the present invention may be described or required in individual form, they may also be understood as multiple unless explicitly limited to the singular.

[0106] It should be understood that, as used herein, the singular form "a" or "an" is intended to include the plural form as well, unless the context clearly supports an exception. It should also be understood that, as used herein, "and / or" refers to any and all possible combinations of one or more of the items listed in association. The serial numbers of the embodiments disclosed in the above embodiments of the present invention are for description only and do not represent the advantages and disadvantages of the embodiments.

[0107] A person skilled in the art should understand that the discussion of any of the above embodiments is only exemplary and is not intended to imply that the scope of the disclosure of the embodiments of the present invention (including the claims) is limited to these examples; under the concept of the embodiments of the present invention, the technical features in the above embodiments or different embodiments can also be combined, and there are many other changes in different aspects of the embodiments of the present invention as above, which are not provided in detail for the sake of simplicity. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the embodiments of the present invention should be included in the protection scope of the embodiments of the present invention.

Claims

1. A Chinese medicine preparation for treating ichthyosis, characterized in that: The Chinese medicine preparation for treating ichthyosis is made from the following raw materials by weight: Salvia miltiorrhiza: 10-35g; Smilax glabra: 10-15g; Sophora flavescens: 10-40g; Dictamni: 10-40g; Red peony root: 10-40g; Rehmannia root: 10-30g; Radix Pseudostellariae: 10-15g; Atractylodes macrocephala: 10-40g; Ligustrum lucidum: 10-15g; Motherwort: 20-60g; Clematis: 10-15g; Honeysuckle vine: 10-40g.

2. The Chinese medicine preparation for treating ichthyosis according to claim 1, characterized in that: The salvia miltiorrhiza, sophora flavescens, dactylic acid bark, red peony root, rehmannia root, and motherwort are the main drugs, Pseudostellaria pseudoginseng, Atractylodes macrocephala, and Ligustrum lucidum are the ministerial drugs, Clematidis is the adjuvant drug, and the rest are guiding drugs, which conforms to the system of syndrome differentiation and treatment in traditional Chinese medicine.

3. The Chinese medicine preparation for treating ichthyosis according to claim 2, characterized in that: The Chinese medicine preparation does not contain any auxiliary materials, and only includes salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, red peony root, rehmannia root, pseudostellaria, atractylodes, glossy privet fruit, motherwort, clematis and honeysuckle vine ingredients.

4. A method for preparing a Chinese medicine preparation for treating ichthyosis according to any one of claims 1 to 3, characterized in that: The following steps are involved: The components of the Chinese medicine preparation, namely, salvia miltiorrhiza, smilax glabra, sophora flavescens, white peony root, red peony root, rehmannia root, pseudoginseng, atractylodes macrocephala, glossy privet fruit, motherwort, clematis root and honeysuckle vine, are crushed into powder; Mix the powders of Salvia miltiorrhiza, Smilax glabra, Sophora flavescens, Dictamni cortex, Paeonia lactiflora, Rehmannia glutinosa, Pseudostellaria baicalensis, Atractylodes macrocephala, Fructus Ligustri Lucidi, Leonurus japonicus, Clematis chinensis and Honeysuckle vine and put them into a container for later use.

5. The method for preparing the Chinese medicine preparation for treating ichthyosis according to claim 4, characterized in that: The components of salvia miltiorrhiza, smilax glabra, sophora flavescens, radix difficile, red peony root, rehmannia root, pseudostellaria, atractylodes macrocephala, fructus ligustris, motherwort, clematis root and honeysuckle vine are respectively ground into 60-80 mesh medicinal powders.

6. The method for preparing the Chinese medicine preparation for treating ichthyosis according to claim 4, characterized in that: The following steps are also included: Process the salvia miltiorrhiza, sophora flavescens, dactylic bark, red peony root, rehmannia root, and motherwort, add rice wine, simmer for a while, then fry until dry, let cool, and sieve out the debris; fry the other part with salt; Process the red peony root, add yellow wine, simmer for a while, heat until it turns slightly yellow, take it out and let it cool, and sieve out the debris; Process the Ligustrum lucidum fruit, mix it with rice wine, steam it until the wine is absorbed and it becomes dark and moist, then dry it.

7. The method for preparing the Chinese medicine preparation for treating ichthyosis according to claim 6, characterized in that: The Chinese medicine preparation is used for treating ichthyosis, and the external treatment method of the Chinese medicine preparation includes taking it twice a day, one dose each time.

8. The method for preparing a Chinese medicine for treating ichthyosis according to claim 7, characterized in that: In the external treatment method of the traditional Chinese medicine preparation, the treatment time and temperature are adjusted according to the age and constitution of the patient; for mild and moderate patients, the treatment cycle is 7 to 14 days, and for severe patients, the treatment cycle is 28-56 days.

9. The method for preparing a Chinese medicine for treating ichthyosis according to claim 8, characterized in that: The preparation method of the Chinese medicine preparation also includes placing the Chinese medicine ingredients into a container and then subjecting it to thermal treatment to exert its efficacy. According to the patient's TCM physical signs, the temperature is adjusted to 36°-45°C and the duration is adjusted to 20-45 minutes.

10. The method for preparing a Chinese medicine for treating ichthyosis according to claim 9, characterized in that: The preparation method of the Chinese medicine preparation also includes loading the Chinese medicine powder into the non-woven medicine bag, and the steps of mixing and loading the Chinese medicine powder into the container are performed according to the principle of monarch, minister, assistant and envoy in the syndrome differentiation and treatment system of traditional Chinese medicine.

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