Emulsifier and application thereof

Abstract

The invention relates to the technical field of materials, and discloses an emulsifier and application thereof. The emulsifier comprises an ionic emulsifier and inorganic salt. Mixing the oil phase and the water phase, performing mechanical emulsification to obtain an oil-in-water crude emulsion, and performing micro-emulsification on the oil-in-water crude emulsion under a microwave condition to obtain a micro-nano emulsion or a micro-nano capsule; wherein the water phase comprises an emulsifier and water. When the emulsifier is used for microwave synergistic preparation of micro-nano emulsion or micro-nano capsule, the reaction temperature is low, the reaction time is short, the particle size is uniform, and the emulsifier can be used in the fields of preparation of micro-nano drugs in the pharmaceutical industry, synthesis of micro-nano emulsion in the cosmetic industry and the like.

Description

Technical Field

[0001] The invention relates to the technical field of materials, and in particular to an emulsifier and application thereof. Background Art

[0002] Suspension polymerization refers to the process in which polymer monomers are dissolved in an organic phase under the action of a suspending agent. As the polymerization reaction proceeds, the polymer undergoes free radical polymerization on the surface of the core material and continuously precipitates from the organic phase, and finally deposits on the surface of the organic droplets to form microcapsules. Suspension polymerization uses water as a medium. Compared with other methods, it is safe and does not require recycling. It has low cost, low equipment investment, high utilization rate, high polymerization yield, and low consumption of raw materials such as catalysts and dispersants.

[0003] Suspension polymerization is one of the common methods for synthesizing polymer capsules. The suspension polymerization method mainly consists of two parts: (1) the two oil phase and water phase reactants are respectively formed into W / O or O / W type emulsion droplets in the presence of surfactants; (2) the emulsion droplets react with the surfactant at the oil-water interface to form a polymer shell. However, the emulsion prepared by the soft template method has the disadvantage of uneven particle size, which limits its industrial application. Therefore, how to prepare micro-nano emulsions with uniform and controllable particle size has become a research hotspot for many scholars.

[0004] Microwave-assisted synthesis is a new green synthesis technology with the advantages of fast and uniform heating, high selectivity, and few side reactions. It is now widely used in organic synthesis, biotechnology, inorganic chemistry, analytical chemistry and other fields. Since the heating mechanism of microwave-assisted heating technology is a dipole polarization mechanism, its essence is body heating, which enhances the transfer of energy to the reactants during the heating process. Compared with traditional thermal polymerization heating, microwave-assisted synthesis greatly reduces the reaction time, increases the reaction yield, and reduces the appearance of by-products. At the same time, since its heating method is a dipole polarization mechanism, it can further control the nucleation and growth of nanomaterials and realize the preparation of micro-nano emulsions. Summary of the invention

[0005] The purpose of the present invention is to overcome the problems existing in the prior art and to provide an emulsifier and its application.

[0006] In order to achieve the above object, the present invention provides an emulsifier in a first aspect, wherein the emulsifier comprises an ionic emulsifier and an inorganic salt.

[0007] The second aspect of the present invention provides a use of the emulsifier described in the first aspect in the microwave-assisted preparation of micro-nano emulsions or micro-nano capsules.

[0008] The third aspect of the present invention provides a method for preparing a micro-nano emulsion or a micro-nano capsule using the emulsifier described in the first aspect, wherein the oil phase and the water phase are mixed and then mechanically emulsified to obtain a crude oil-in-water emulsion, and then the crude oil-in-water emulsion is microemulsified under microwave conditions to obtain a micro-nano emulsion or a micro-nano capsule; wherein the water phase comprises an emulsifier and water.

[0009] The fourth aspect of the present invention provides a micro-nano emulsion or micro-nano capsule obtained by the method described in the third aspect.

[0010] The fifth aspect of the present invention provides the use of the method described in the third aspect in the preparation of cosmetics and micro-nano drugs.

[0011] Through the above technical solution, the beneficial technical effects achieved by the present invention are as follows:

[0012] (1) The emulsifier provided by the present invention is used for microemulsification under microwave conditions, so that the mechanically emulsified coarse emulsion can be refined under a microenvironment, and finally a micro-nano emulsion or micro-nano capsule with uniform particle size can be obtained; further, by adjusting the amount and type of the two components, micro-nano emulsions or micro-nano capsules with different particle sizes can be synthesized ultra-fast as needed.

[0013] (2) When the emulsifier of the present invention is used for the microwave-assisted preparation of micro-nano emulsions or micro-nano capsules, the reaction temperature is low, the reaction time is short, and the particle size is uniform. It can be used in the preparation of micro-nano drugs in the pharmaceutical industry and the synthesis of micro-nano emulsions in the cosmetics industry. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is the experimental flow chart of the present invention;

[0015] Figure 2 These are electron microscope images of the micro-nanocapsules prepared in Examples 8-14 of the present invention; wherein ag are scanning electron microscope images of Examples 8-14, and h is a transmission electron microscope image of Example 14. DETAILED DESCRIPTION

[0016] The endpoints and any values ​​of the ranges disclosed in this article are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this article.

[0017] A first aspect of the present invention provides an emulsifier, wherein the emulsifier comprises an ionic emulsifier and an inorganic salt.

[0018] The present invention adopts an ionic emulsifier and an inorganic salt compound as an emulsifier, and when the emulsifier is used for microemulsification in a microenvironment, the microemulsification can be accelerated through the common ion effect.

[0019] The present invention can adjust the dosage and types of the two components to ultra-rapidly synthesize stable micro-nano emulsions or micro-nano capsules with different particle sizes as required.

[0020] In some embodiments of the present invention, the ionic emulsifier is selected from at least one of styrene-maleic anhydride copolymer sodium salt (SMA), dihexyl sulfosuccinate sodium salt and sodium allyloxyhydroxypropyl sulfonate, preferably styrene-maleic anhydride copolymer sodium salt.

[0021] In some embodiments of the present invention, the inorganic salt is selected from at least one of sodium chloride, potassium chloride, potassium sulfate, zinc chloride and magnesium chloride, preferably sodium chloride. The sodium ions in sodium chloride can have a common ion effect with the sodium ions in the ionic emulsifier, and the microemulsification effect is better than that of other inorganic salts.

[0022] In some embodiments of the present invention, the mass ratio of the ionic emulsifier to the inorganic salt is 2.5-4.5:0.3-2.1, preferably 3.5:2.1.

[0023] The second aspect of the present invention provides a use of the emulsifier described in the first aspect in the microwave-assisted preparation of micro-nano emulsions or micro-nano capsules.

[0024] The third aspect of the present invention provides a method for preparing a micro-nano emulsion or a micro-nano capsule using the emulsifier described in the first aspect, wherein the oil phase and the water phase are mixed and then mechanically emulsified to obtain a crude oil-in-water emulsion, and then the crude oil-in-water emulsion is micro-emulsified under microwave conditions to obtain a micro-nano emulsion or a micro-nano capsule;

[0025] Wherein, the aqueous phase comprises an emulsifier and water.

[0026] In the present invention, microemulsification is the process in which the ions of the emulsifier micro-cut and refine the coarse emulsion in an alternating electromagnetic field under the microwave dipole polarization mechanism.

[0027] The micro-nano emulsion refers to a micron or nano emulsion with uniform particle size obtained by refining a coarse emulsion. The micro-nano capsule refers to a microcapsule synthesized by using the micro-nano emulsion after adding an initiator.

[0028] In the present invention, microemulsification can be performed in a multimode microwave reactor.

[0029] In the present invention, when the oil phase does not contain an initiator, a micro-nano emulsion is obtained; when the oil phase contains an initiator, a micro-nano capsule is obtained. When the oil phase contains an initiator, the micro-emulsified product is demulsified, centrifuged, and dried to obtain a micro-nano capsule. The obtained micro-nano capsule has a regular structure, a uniform particle size, an average particle size of 0.05-5 μm, and a distinct core-shell structure.

[0030] The micro-nano emulsion of the invention has uniform particle size and forms a good oil-in-water emulsion structure.

[0031] In some embodiments of the present invention, in the aqueous phase, the mass percentage of the emulsifier relative to the mass of water is 2.8-6.6%, preferably 5.6%.

[0032] In some embodiments of the present invention, the mass percentage of the ionic emulsifier in the aqueous phase relative to the mass of water is 2.5-4.5%, preferably 3.5%. In the present invention, too little use of the ionic emulsifier will result in poor emulsification effect, too much large emulsion, and too large particle size; too much use of the ionic emulsifier will result in too high emulsion viscosity, which is not conducive to the cutting of the microcapsules by inorganic salts in the microenvironment, and easily leads to the fusion of small droplets in the emulsion.

[0033] In some embodiments of the present invention, the mass percentage of the inorganic salt in the aqueous phase relative to the mass of water is 0.3-2.1%, preferably 2.1%. In the present invention, if the amount of the inorganic salt is too small, it will not be able to completely cut and refine the emulsion in the microwave, resulting in the presence of both micron-scale and nano-scale emulsions in the obtained micro-nano emulsion, and the uniformity of the particle size is poor; if the amount of the inorganic salt is too large, the micro-nano emulsion will be refined to the limit particle size in the microwave environment.

[0034] In some embodiments of the present invention, the oil phase comprises a core material, a wall material, an optional cross-linking agent, and an optional initiator.

[0035] In some embodiments of the present invention, the core material is selected from at least one of n-octadecane, n-hexane, n-heptane and n-tetradecane.

[0036] In some embodiments of the present invention, the wall material is selected from at least one of methyl methacrylate (MMA), styrene and N,N-dimethylacrylamide, preferably methyl methacrylate.

[0037] In some embodiments of the present invention, the cross-linking agent is selected from at least one of allyl methacrylate (AMA), sodium salt of dihexyl sulfosuccinate and sodium allyloxyhydroxypropyl sulfonate, preferably allyl methacrylate.

[0038] In some embodiments of the present invention, the initiator is an azo initiator.

[0039] In some embodiments of the present invention, the initiator is selected from at least one of azobisisobutyronitrile, azobisisovaleronitrile, azobisisoheptanenitrile, diethyl azodicarboxylate, dimethyl azobisisobutyrate and azodicarbonamide.

[0040] In some embodiments of the present invention, the mass percentage of the core material is 5-7%, preferably 6%, relative to the mass of water in the aqueous phase.

[0041] In some embodiments of the present invention, the mass percentage of the wall material is 4-6%, preferably 5%, relative to the mass of water in the aqueous phase.

[0042] In some embodiments of the present invention, the mass percentage of the cross-linking agent is 0.5-1%, preferably 0.8%, relative to the mass of water in the aqueous phase.

[0043] In some embodiments of the present invention, the mass percentage of the initiator relative to the mass of water in the aqueous phase is 0.2-0.5%, preferably 0.4%.

[0044] In some embodiments of the present invention, the conditions for mechanical emulsification include: a stirring rate of 6000-9000 rpm, preferably 8000 rpm; and a time of 5-20 min, preferably 10 min.

[0045] In some embodiments of the present invention, the microemulsification conditions include: temperature of 50-70°C, preferably 60°C; time of 0-42 min, preferably 7-35 min; power of 100-700w, preferably 600w. The reaction temperature is low and there is no safety risk. In addition, the microemulsification can be carried out under normal pressure.

[0046] The fourth aspect of the present invention provides a micro-nano emulsion or micro-nano capsule obtained by the method described in the third aspect.

[0047] The fifth aspect of the present invention provides the use of the method described in the third aspect in the preparation of cosmetics and micro-nano drugs. Those skilled in the art can select raw materials (such as core materials, wall materials) according to actual applications.

[0048] The present invention will be described in detail below through examples.

[0049] In the following examples and comparative examples, if no specific conditions are specified, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used, if no manufacturer is specified, are all conventional products that can be obtained through commercial channels.

[0050] Styrene-maleic anhydride copolymer sodium salt: purchased from Shanghai Leather Chemical Factory, with a weight average molecular weight of 4000 g / mol.

[0051] Example 1

[0052] This example is used to illustrate the preparation of micro-nano emulsion.

[0053] (1) 6 g (6%) of n-octadecane, 5 g (5%) of methyl methacrylate (MMA) and 0.8 g (0.8%) of allyl methacrylate (AMA) were mixed to form an oil phase;

[0054] (2) 100 mL of deionized water, 3.5 g (3.5%) of styrene-maleic anhydride copolymer sodium salt (SMA) and 0.3 g (0.3%) of NaCl were mixed to form the aqueous phase;

[0055] (3) mixing the oil phase and the water phase and performing mechanical emulsification at 8000 rpm for 10 min to form an oil-in-water crude emulsion;

[0056] (4) The micro-nano emulsion was formed by reacting in a microwave reactor at 60°C and 600W for 35 min.

[0057] Example 2

[0058] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 0.6 g (0.6%).

[0059] Example 3

[0060] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 0.9 g (0.9%).

[0061] Example 4

[0062] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 1.2 g (1.2%).

[0063] Example 5

[0064] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 1.5 g (1.5%).

[0065] Example 6

[0066] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 1.8 g (1.8%).

[0067] Example 7

[0068] The micro-nano emulsion was prepared according to the method of Example 1, except that the mass of NaCl in step (2) was 2.1 g (2.1%).

[0069] Example 8

[0070] (1) 6 g (6%) of n-octadecane, 5 g (5%) of methyl methacrylate (MMA), and 0.8 g (0.8%) of allyl methacrylate (AMA) were mixed, and then 0.4 g (0.4%) of azobisisobutyronitrile was added as an oil phase;

[0071] (2) 100 mL of deionized water, 3.5 g (3.5%) of styrene-maleic anhydride copolymer sodium salt (SMA) and 0.3 g (0.3%) of NaCl were mixed to form the aqueous phase;

[0072] (3) mixing the oil phase and the water phase and performing mechanical emulsification at 8000 rpm for 10 min to form an oil-in-water crude emulsion;

[0073] (4) The micro-nanocapsules were formed by reacting in a microwave reactor at 60°C and 600W for 35 min.

[0074] Example 9

[0075] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 0.6 g (0.6%).

[0076] Example 10

[0077] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 0.9 g (0.9%).

[0078] Embodiment 11

[0079] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 1.2 g (1.2%).

[0080] Example 12

[0081] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 1.5 g (1.5%).

[0082] Embodiment 13

[0083] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 1.8 g (1.8%).

[0084] Embodiment 14

[0085] Micro-nanocapsules were prepared according to the method of Example 8, except that the mass of NaCl in step (2) was 2.1 g (2.1%).

[0086] Embodiment 15

[0087] Micro-nanocapsules were prepared according to the method of Example 14, except that NaCl in step (2) was replaced by KCl.

[0088] Example 16

[0089] Micro-nanocapsules were prepared according to the method of Example 14, except that NaCl in step (2) was replaced by MgCl2.

[0090] Embodiment 17

[0091] Micro-nanocapsules were prepared according to the method of Example 14, except that NaCl in step (2) was replaced by ZnCl2.

[0092] Embodiment 18

[0093] Micro-nanocapsules were prepared according to the method of Example 14, except that NaCl in step (2) was replaced by K2SO4.

[0094] Embodiment 19

[0095] (1) 6 g (6%) of n-octadecane, 5 g (5%) of methyl methacrylate (MMA) and 0.8 g (0.8%) of allyl methacrylate (AMA) were mixed to form an oil phase;

[0096] (2) 100 mL of deionized water, 2.5 g (2.5%) of styrene-maleic anhydride copolymer sodium salt (SMA) and 2.1 g (2.1%) of NaCl were mixed to form the aqueous phase;

[0097] (3) mixing the oil phase and the water phase and performing mechanical emulsification at 8000 rpm for 10 min to form an oil-in-water crude emulsion;

[0098] (4) The micro-nano emulsion was formed by reacting in a microwave reactor at 60°C and 600W for 35 min.

[0099] Embodiment 20

[0100] The micro-nano emulsion was prepared according to the method of Example 19, except that the mass of SMA in step (2) was 3.0 g (3.0%).

[0101] Embodiment 21

[0102] The micro-nano emulsion was prepared according to the method of Example 19, except that the mass of SMA in step (2) was 4.0 g (4.0%).

[0103] Embodiment 22

[0104] The micro-nano emulsion was prepared according to the method of Example 19, except that the mass of SMA in step (2) was 4.5 g (4.5%).

[0105] Embodiment 23

[0106] The micro-nano emulsion was prepared according to the method of Example 7, except that the reaction time in step (4) was 7 min.

[0107] Embodiment 24

[0108] The micro-nano emulsion was prepared according to the method of Example 7, except that the reaction time in step (4) was 14 min.

[0109] Embodiment 25

[0110] The micro-nano emulsion was prepared according to the method of Example 7, except that the reaction time in step (4) was 21 min.

[0111] Embodiment 26

[0112] The micro-nano emulsion was prepared according to the method of Example 7, except that the reaction time in step (4) was 28 min.

[0113] Embodiment 27

[0114] The micro-nano emulsion was prepared according to the method of Example 7, except that the reaction time in step (4) was 42 min.

[0115] Comparative Example 1

[0116] The micro-nano emulsion was prepared according to the method of Example 7, except that NaCl was not added in step (2).

[0117] Comparative Example 2

[0118] Microcapsules were prepared according to the method of Example 8, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form microcapsules.

[0119] Comparative Example 3

[0120] Microcapsules were prepared according to the method of Example 9, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form the microcapsules.

[0121] Comparative Example 4

[0122] Microcapsules were prepared according to the method of Example 10, except that step (4) was to form the microcapsules by reacting at 60° C. for 10 h under hydrothermal conditions.

[0123] Comparative Example 5

[0124] Microcapsules were prepared according to the method of Example 11, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form the microcapsules.

[0125] Comparative Example 6

[0126] Microcapsules were prepared according to the method of Example 12, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form the microcapsules.

[0127] Comparative Example 7

[0128] Microcapsules were prepared according to the method of Example 13, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form the microcapsules.

[0129] Comparative Example 8

[0130] Microcapsules were prepared according to the method of Example 14, except that step (4) was carried out under hydrothermal conditions at 60° C. for 10 h to form the microcapsules.

[0131] Test Example 1

[0132] The micro-nano emulsions obtained in Examples 1-7, 19-27 and Comparative Example 1 were structurally characterized using a polarizing microscope and a laser particle size and potential analyzer. The prepared emulsions had obvious structures and uniform particle sizes.

[0133] The average particle size results are shown in Table 1.

[0134] Table 1

[0135]

[0136]

[0137] As can be seen from Table 1, the particle size of the obtained micro-nano emulsion can be controlled by adjusting the dosage of the inorganic salt (such as sodium chloride) and the ionic emulsifier (such as SMA) and the reaction time in the microwave reactor.

[0138] From the comparison between Examples 1-7 and Examples 19-27, it can be seen that the particle size of the micro-nano emulsion prepared in Example 7 is the smallest. In Comparative Example 1, when NaCl is not added but the amount of SMA and the reaction time are the same as those in Example 7, only an emulsion with a micron-sized particle size can be obtained, and nano-level regulation cannot be achieved.

[0139] Test Example 2

[0140] The micro-nano capsules obtained in Examples 8-18 were structurally characterized using a scanning electron microscope. The prepared micro-nano capsules had an obvious core-shell structure and full particles.

[0141] The average particle size results are shown in Table 2.

[0142] Table 2

[0143]

[0144]

[0145] It can be seen from Table 2 that the particle size of the obtained micro-nano capsules can be controlled by adjusting the amount and type of inorganic salts.

[0146] It can be seen from Comparative Examples 2-8 that only microcapsules of micrometer size can be synthesized under hydrothermal conditions.

[0147] The preferred embodiments of the present invention are described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, the technical solution of the present invention can be subjected to a variety of simple modifications, including the combination of various technical features in any other suitable manner, and these simple modifications and combinations should also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention.

Claims

1. An emulsifier, characterized in that The emulsifiers include ionic emulsifiers and inorganic salts.

2. The emulsifier according to claim 1, wherein The ionic emulsifier is selected from at least one of styrene-maleic anhydride copolymer sodium salt, dihexyl sulfosuccinate sodium salt and sodium allyloxy hydroxypropyl sulfonate, preferably styrene-maleic anhydride copolymer sodium salt; Preferably, the inorganic salt is selected from at least one of sodium chloride, potassium chloride, potassium sulfate, zinc chloride and magnesium chloride, preferably sodium chloride.

3. The emulsifier according to claim 1 or 2, wherein The mass ratio of the ionic emulsifier to the inorganic salt is 2.5-4.5:0.3-2.1, preferably 3.5:2.

1.

4. Use of the emulsifier according to any one of claims 1 to 3 in the microwave-assisted preparation of micro-nano emulsions or micro-nano capsules.

5. A method for preparing micro-nano emulsion or micro-nano capsule using the emulsifier according to any one of claims 1 to 3, characterized in that: The oil phase and the water phase are mixed and then mechanically emulsified to obtain a crude oil-in-water emulsion, and then the crude oil-in-water emulsion is micro-emulsified under microwave conditions to obtain a micro-nano emulsion or micro-nano capsule; Wherein, the aqueous phase comprises an emulsifier and water.

6. The method according to claim 5, wherein: In the aqueous phase, the mass percentage of the emulsifier relative to the mass of water is 2.8-6.6%, preferably 5.6%; Preferably, in the aqueous phase, the mass percentage of the ionic emulsifier relative to the mass of water is 2.5-4.5%, preferably 3.5%; Preferably, in the aqueous phase, the mass percentage of the inorganic salt relative to the mass of water is 0.3-2.1%, preferably 2.1%.

7. The method according to claim 5 or 6, wherein: The oil phase includes a core material, a wall material, an optional cross-linking agent, and an optional initiator; Preferably, the core material is selected from at least one of n-octadecane, n-hexane, n-heptane and n-tetradecane; Preferably, the wall material is selected from at least one of methyl methacrylate, styrene and N,N-dimethylacrylamide, preferably methyl methacrylate; Preferably, the cross-linking agent is selected from at least one of allyl methacrylate, ethylene glycol dimethacrylate and triallyl cyanurate, preferably allyl methacrylate; Preferably, the initiator is an azo initiator; Preferably, the initiator is selected from at least one of azobisisobutyronitrile, azobisisovaleronitrile, azobisisoheptanenitrile, diethyl azodicarboxylate, dimethyl azobisisobutyrate and azodicarbonamide; Preferably, the mass percentage of the core material relative to the mass of water in the aqueous phase is 5-7%, preferably 6%; Preferably, the mass percentage of the wall material relative to the mass of water in the aqueous phase is 4-6%, preferably 5%; Preferably, the mass percentage of the cross-linking agent relative to the mass of water in the aqueous phase is 0.5-1%, preferably 0.8%; Preferably, the mass percentage of the initiator relative to the mass of water in the aqueous phase is 0.2-0.5%, preferably 0.4%.

8. The method according to any one of claims 5 to 7, wherein: The mechanical emulsification conditions include: a stirring rate of 6000-9000 rpm, preferably 8000 rpm; a time of 5-20 min, preferably 10 min; Preferably, the microemulsification conditions include: temperature of 50-70°C, preferably 60°C; time of 0-42 min, preferably 7-35 min; power of 100-700w, preferably 600w.

9. The micro-nano emulsion or micro-nano capsule obtained according to the method described in any one of claims 5 to 8.

10. Use of the method according to any one of claims 5 to 8 in the preparation of cosmetics and micro-nano drugs.

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