Liquid chromatograph

Abstract

The invention belongs to the technical field of substance analysis instruments, and particularly relates to a liquid chromatograph which comprises a tray, an infusion apparatus, a column oven and a detection box which are sequentially arranged from top to bottom, the detection box comprises a shell, a light source and a detection element, the light source and the detection element are arranged in the shell, a detection space is formed in the first side of the shell and located outside the shell, a partition plate is detachably arranged in the shell, and the light source and the detection element are arranged in the shell. A closed heat dissipation space surrounding the lamp source is formed among the partition plate, the bottom wall of the shell and the side wall of the first side of the shell, and the heat dissipation space extends from the first side to the third side of the shell. Through the structure, the invention comprehensively provides a heat dissipation scheme for limiting heat to a limited area and rapidly leading out the heat through the direct-flow type convection air duct.

Description

Technical Field

[0001] The invention belongs to the technical field of material analysis instruments, and in particular relates to a liquid chromatograph. Background Art

[0002] Liquid chromatograph is an analytical instrument widely used in chemical analysis, biomedicine, environmental monitoring and other fields. It can achieve qualitative and quantitative analysis of each component in a complex mixture by separating and detecting samples in the mobile phase. In liquid chromatograph, UV detector is one of the most commonly used detection methods, and the UV detector light source (i.e. light source) usually uses deuterium lamp and tungsten lamp.

[0003] Among them, deuterium lamps can provide a continuous ultraviolet spectrum of 190-400nm, which is suitable for detecting compounds with strong ultraviolet absorption; tungsten lamps are mainly used for detection in the visible light region (400-700nm). However, these two lamps generate a lot of heat when working, and their operating temperatures are usually high. For example, the operating temperature of deuterium lamps can reach more than 200℃, and the operating temperature of tungsten lamps can also reach hundreds of degrees Celsius.

[0004] In a high temperature environment, the heat dissipation of the lamp source becomes one of the key factors affecting the performance of the liquid chromatograph. If the heat dissipation effect is not good, the following problems may occur: Shortened lamp life: High temperature will accelerate the aging and evaporation of the filament, reducing the service life of the lamp.

[0005] Decreased detection accuracy: Temperature changes will affect the luminous intensity and wavelength stability of the light source, thereby affecting the accuracy and repeatability of the detection results.

[0006] Increased risk of instrument failure: Excessively high temperatures may cause damage to other components inside the detector, affecting the normal operation of the instrument.

[0007] Therefore, how to effectively solve the heat dissipation problem of the lamp source in the liquid chromatograph is of great significance to improving the performance and reliability of the instrument. At present, although there are some heat dissipation technologies applied to liquid chromatographs on the market, these technologies still have problems such as low heat dissipation efficiency, complex structure, and high cost. Therefore, developing an efficient, stable and low-cost heat dissipation device has important research value and application prospects for improving the overall performance of liquid chromatographs. Summary of the invention

[0008] The object of the present invention is to provide a liquid chromatograph to ensure the working independence between various components of the chromatograph and improve the stability of the chromatograph.

[0009] In order to solve the above-mentioned technical problems, the present invention specifically adopts the following technical solutions: A liquid chromatograph, comprising a tray, an infusion set, a column temperature box and a detection box arranged in sequence from top to bottom; the detection box comprises a shell, and a light source and a detection element arranged inside the shell, a detection space is arranged on a first side of the shell, and the detection space is located outside the shell; A partition is detachably provided inside the shell, and a closed heat dissipation space enclosed around the lamp source is formed between the partition, the bottom wall of the shell, and the side wall of the first side of the shell, and the heat dissipation space extends from the first side to the third side of the shell; The heat dissipation space is divided into a cooling zone, a drainage channel and a heat dissipation zone in sequence from the first end to the second end. An air inlet is arranged on at least one side wall of the cooling zone, and an air suction device is arranged at the air inlet. The light source is arranged in the cooling zone corresponding to the air suction device; the heat dissipation zone is provided with an air outlet corresponding to the third side of the shell, and an exhaust device is arranged at the air outlet; accordingly, at least one air inlet corresponding to the air suction device and an exhaust hole corresponding to the exhaust device are respectively arranged on the shell.

[0010] As an improvement, the drainage channel is divided into a gathering section, an acceleration section and a buffer section from its first end to its second end, and the inner diameter of the acceleration section is smaller than the inner diameters of the gathering section and the buffer section.

[0011] As an improvement, two air inlets are provided, and the two air inlets are respectively located on the top of the partition and one of the side walls.

[0012] As an improvement, the detection space is formed by an outer surface of the first side of the housing being recessed inwardly, and a sample detection area corresponding to the opening and an installation area for installing a water pipe are provided in the detection space.

[0013] As an improvement, the chromatograph further comprises a water guide assembly, the water guide assembly comprises a water guide pipe and a water guide column, the water guide column is arranged in the installation area, and the water guide pipe is detachably connected to the water guide column.

[0014] As an improvement, a plurality of first magnetic elements are arranged on the detection space; the detection box further comprises a magnetic suction door, and a plurality of second magnetic elements corresponding to the first magnetic elements are arranged on the magnetic suction door; When the magnetic door is installed on the shell through the second magnetic element and the first magnetic element, the shell and the magnetic door enclose the closed detection space.

[0015] As an improvement, a water guide groove is provided at the bottom of the detection space, and the height of the water guide groove gradually decreases from its first end to the second end, so that the water guide groove forms an inclined drainage slope, and a waste liquid outflow outlet is provided at the second end of the water guide groove.

[0016] As an improvement, the partition is arranged close to the second side of the shell, and the detection element is arranged close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0017] As an improvement, a water guide groove is provided at the bottom of the infusion pump and the column temperature box, and the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and a waste liquid outflow outlet is provided at the second end of the water guide groove.

[0018] As an improvement, the two side edges of the partition that contact the bottom wall of the shell extend to both sides of the heat dissipation space to form curled edges parallel to the bottom wall, and at least two clamping blocks are provided on the bottom wall; when the two curled edges are fixed respectively by the at least two clamping blocks, the curled edges are attached to the bottom wall.

[0019] The principle and beneficial technical effects of the present invention are: In the prior art, the heat dissipation method of the chromatograph is mostly to set an exhaust device on the side wall of the detection box to extract the hot air indiscriminately distributed inside the detection box, so as to achieve the purpose of heat dissipation. For example, the Chinese utility model patent with application number 202120699737.2 discloses an ion chromatograph; wherein, the lamp source (usually a deuterium lamp and a tungsten lamp, that is, a heat source) is exposed to the entire cavity of the detection box, and a large amount of heat generated by the lamp source will be quickly distributed to the entire cavity. For example, in the case of low ambient temperature such as cold storage, even if the heat is dissipated into the cavity, the heat in the cavity will exchange heat with the cold air in the environment, and the exhaust device arranged on the side wall of the detection box can basically achieve cooling in the cavity. However, if the ambient temperature is high (for example, in a general laboratory, especially in the case of power rationing in summer, the air conditioning temperature cannot be adjusted too low, and the indoor temperature is about 20-25°), if a large amount of heat is stored inside the cavity, and the heat in the cavity exchanges heat with the air in the environment at a slow rate, it is difficult for the exhaust device installed on the side wall of the test box to achieve rapid cooling in the cavity.

[0020] In response to the above situation, the present application comprehensively provides a fixed-point heat dissipation solution that limits the large amount of heat generated by the lamp source to a limited area and quickly draws out the heat by setting a guiding path, namely a "DC" convection air duct.

[0021] Specifically, the present solution sets a heat dissipation space extending from the first side to the third side of the shell, cooperates with the suction device and the exhaust device respectively located on both sides of the heat dissipation space, so as to simultaneously introduce cold air into the heat dissipation space and extract hot air from the heat dissipation space, so that the air inside the heat dissipation space is quickly drained from its first end to the second end for discharge, thereby realizing rapid and centralized heat dissipation of the lamp source. On the one hand, a large amount of heat generated by the lamp source can be concentrated in the heat dissipation space, thereby preventing the heat from diffusing outside the heat dissipation space and causing adverse effects on the detection elements in the shell or the area where the water pipes on the shell are located; on the other hand, the drainage channel can buffer the heat, that is, the heat generated by the lamp source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessive temperature of the lamp source; and the "direct current" air duct design can make the airflow path clear, thereby being able to efficiently bring the heat out of the channel, avoiding heat accumulation in the channel.

[0022] Furthermore, based on the fact that the drainage channel is relatively long (i.e., it runs through the entire shell), the present application divides the drainage channel into a plurality of functional zones with different inner diameters. During operation of the chromatograph, after the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the acceleration effect of the acceleration section causes the gathering section to form a negative pressure, thereby quickly leading the hot air to the gathering section for gathering, so as to prevent the hot air after the heat exchange from mixing with the cold air newly entering the cooling zone, thereby reducing the heat dissipation effect, thereby ensuring that the air around the lamp source has a large temperature difference with the lamp source. Then, the hot air gathered in the gathering section immediately enters the acceleration section and is quickly discharged to the buffer section, and then is discharged under the action of the exhaust device. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the cavity (i.e., other areas outside the heat dissipation space in the shell). On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in the inner diameters of the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, the present application also provides a "rapid drainage anti-backflow heat dissipation structure". BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, each element or part is not necessarily drawn according to the actual scale. Obviously, the drawings described below are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without paying creative labor.

[0024] Figure 1 It is a schematic diagram of the overall structure of the chromatograph in an embodiment of the present invention; Figure 2It is a schematic structural diagram of a detection box in an exemplary embodiment of the present invention; Figure 3 is a schematic structural diagram of a detection box in another exemplary embodiment of the present invention; Figure 4 It is a structural schematic diagram of a magnetic suction door in an embodiment of the present invention; Figure 5 A schematic diagram of a detection box at another angle in an embodiment of the present invention; Figure 6 It is a schematic diagram showing four sides of the detection box in an embodiment of the present invention; Figure 7 This is a schematic diagram of the internal structure of the detection box in an embodiment of the present invention; Figure 8 This is a schematic diagram of the internal structure of the detection box after the partition is removed in an embodiment of the present invention; Fig. 9 It is a partial schematic diagram of the interior of the detection box in an embodiment of the present invention; Fig.10 Another partial schematic diagram of the interior of the detection box in an embodiment of the present invention; Fig.11 An exploded view of the internal structure of the detection box in an embodiment of the present invention; Fig.12 Schematic diagram of the installation structure of the water pipe in the embodiment of the present invention; Fig.13 It is a schematic diagram of a partial installation structure of a water pipe in an embodiment of the present invention; Fig.14 Schematic diagram of the installation relationship between the water guide pipe and the water guide column in an embodiment of the present invention; Fig.15 It is a partial structural schematic diagram of a column oven in an embodiment of the present invention; Fig.16 It is a schematic diagram of the partition structure of the heat dissipation space in an embodiment of the present invention; Fig.17 This is a schematic diagram of the internal structure of the drainage channel in an embodiment of the present invention; Fig.18 is a schematic diagram of the internal structure of another exemplary drainage channel in an embodiment of the present invention; Fig.19 An exploded view of a drainage system in an embodiment of the present invention; Fig. 20 It is a partial side view of the column oven in the embodiment of the present invention; Fig.21 It is a partial schematic diagram showing the structure of the fixing clip in the column oven in an embodiment of the present invention; Fig. 22 4 is a cross-sectional view of a column oven in an embodiment of the present invention.

[0025] Markings in the figure: 1. tray; 2. infusion set; 3. column temperature box; 300. shell; 301. heat conduction part; 302. mounting part; 303. chromatographic column; 304. fixing clamp; 341. upper clamp; 342. lower clamp; 343. guide space; 344. clamping space; 345. connection part; 305. heating tube; 306. temperature sensor; 307. cold end; 308. elastic part; 309. pull rod motor; 310. heat sink; 311. cooling fan; 312. refrigeration sheet; 4. detection box; 401. first side; 402. second side; 403. third side; 404. fourth side; 41. shell; 411. air inlet; 412. exhaust hole; 413. first magnetic element; 42. detection element; 43. detection space; 431. sample Product inspection area; 432, installation area; 433, limiting step; 434, limiting protrusion; 435, slot; 436, groove; 44, block; 45, magnetic door; 451, second magnetic element; 46, light source; 5, partition; 51, curling; 52, air inlet; 53, air outlet; 54, installation plate; 6, air suction device; 7, exhaust device; 8, water guide column; 81, buckle; 82, water guide cavity; 83, water guide channel; 84, transition section; 85, connecting section; 9, water guide pipe; 10, water guide groove; 11, waste liquid outflow outlet; 12, thermal insulation cotton; 13, cooling area; 14, drainage channel; 141, gathering section; 142, acceleration section; 1421, reduction section; 1422, recovery section; 143, buffer section; 15, heat dissipation area; 16, inspection window. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0027] Herein, the suffixes such as "module", "component" or "unit" used to represent elements are used only to facilitate the description of the present invention and have no specific meaning in themselves. Therefore, "module", "component" or "unit" can be used in a mixed manner. Herein, the orientation or positional relationship indicated by the terms "upper", "lower", "inner", "outer", "front", "back", "one end", "the other end", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0028] In this document, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In this document, "plurality" means two or more, that is, it includes two, three, four, five, etc.

[0029] Embodiment 1 In the prior art, the heat dissipation method of the chromatograph is mostly to set an exhaust device on the side wall of the detection box to extract the hot air distributed inside the detection box, so as to achieve the purpose of heat dissipation. For example, the Chinese utility model patent with application number 202120699737.2 discloses an ion chromatograph; wherein, the lamp source (usually a deuterium lamp and a tungsten lamp, that is, a heat source) is exposed to the entire cavity of the detection box, and a large amount of heat generated by the lamp source will be quickly distributed to the entire cavity. For example, in the case of low ambient temperature such as cold storage, even if the heat is dissipated into the cavity, the heat in the cavity will exchange heat with the cold air in the environment, and the exhaust device arranged on the side wall of the detection box can basically achieve cooling in the cavity. However, this method has at least the following defects: for example, the heat generated by the lamp source is indiscriminately distributed throughout the entire cavity of the detection box. When the detection elements located in the cavity are heated, it is very likely that their measurement results will be inaccurate; for example, if some components in the detection box (such as the water pipe located in the detection cavity) are exposed to a high temperature environment for a long time, their aging will inevitably be accelerated.

[0030] In addition, if the ambient temperature is high (for example, in a general laboratory, especially in the case of power rationing in summer, the air conditioning temperature cannot be adjusted too low, and the indoor temperature is about 20-25°), if a large amount of heat is stored inside the cavity, and the heat in the cavity exchanges heat with the air in the environment at a slow rate, it is difficult for the exhaust device installed on the side wall of the test box to achieve rapid cooling in the cavity.

[0031] The present application comprehensively provides a fixed-point heat dissipation solution that limits the large amount of heat generated by the lamp source to a limited area and quickly draws the heat out by setting a guiding path, namely a "DC" convection air duct.

[0032] Specifically, this embodiment is basically as shown in the attached Figure 1-17 As shown: See also Figure 1 The present invention provides a liquid chromatograph, comprising a tray 1, an infusion set 2, a column temperature box 3 and a detection box 4 which are arranged in sequence from top to bottom.

[0033] In some embodiments, see Fig.15 , the column oven includes a heat-conducting space for installing a heating device and a refrigerating device, and an installation space for installing a chromatographic column, a heat-conducting part 301 is arranged between the heat-conducting space and the installation space, the heat-conducting space and the installation space are separated by the heat-conducting part 301, the heat-conducting part 301 is provided with a mounting member 302 near the installation space, and the mounting member 302 is provided with a plurality of slots of different lengths, and the chromatographic column 303 can be stuck on the slot. It should be noted that the mounting member is also made of heat-conducting material, that is, the heat or cold source generated by the heating device or the refrigerating device in the heat-conducting space can be directly conducted to the chromatographic column in a surface contact manner through the heat-conducting part and the mounting member in sequence. Compared with the traditional method of heating by introducing hot air, the chromatographic column in this scheme is heated by a surface contact method, and the heating effect is better. Further, the slots in this application are provided with a plurality of different lengths, which can match chromatographs of different lengths and have a wider applicability.

[0034] See also Figure 2 and Figure 3 The detection box includes a shell 41, and a light source and a detection element arranged inside the shell 41. A detection space 43 is arranged on the first side of the shell, and the detection space 43 is located outside the shell 41.

[0035] See also Figure 7-Figure 11A partition 5 is detachably provided inside the shell 41, and a closed heat dissipation space enclosed around the lamp source 46 is formed between the partition 5 and the bottom wall of the shell 41 and the side wall of the first side of the shell. The heat dissipation space extends from the first side to the third side of the shell; that is, the heat dissipation space is a straight channel, and the hot air in the heat dissipation space can be discharged directly from the first end to the second end thereof, and the heat dissipation efficiency is high.

[0036] See also Fig.16 The heat dissipation space is divided into a cooling zone 13, a drainage channel 14 and a heat dissipation zone 15 from the first end to the second end. An air inlet 52 is provided on at least one side wall of the cooling zone 13. An air suction device 6 is provided at the air inlet 52. The light source 46 is provided in the cooling zone 13 and corresponds to the air suction device 6. The heat dissipation zone 15 is provided with an air outlet 53 corresponding to the third side of the housing 41. An exhaust device 7 is provided at the air outlet 53. Accordingly, see Figure 5 , the shell is provided with at least one air inlet 411 corresponding to the air suction device, and an air outlet 412 corresponding to the air exhaust device. That is to say, the air inlet is provided on the side wall of the shell, and the air outlet is provided on the rear side of the shell, which will not affect the user's operation; that is, the air inlet and the air outlet are respectively located at the two ends of the heat dissipation space, and the heat dissipation space runs through the entire shell.

[0037] In some embodiments, see Fig.11 The partition is an N-shaped partition with openings at both ends. A mounting plate 54 is provided at the opening of the second end of the partition. The exhaust device is provided on the mounting plate 54. When the partition 5 and the mounting plate 54 are installed in the shell 41, the partition 5, the mounting plate 54 and the bottom wall of the shell 41 and the side wall of the first side enclose a heat dissipation space.

[0038] In some embodiments, the air suction device and the air exhaust device are both fans (preferably silent fans).

[0039] The present application corresponds the lamp source (also known as the heat source) to the cooling zone, and the cold air sucked in by the suction device is directly blown onto the lamp source, which can directly and quickly cool it down. The hot air generated by the cold air blowing through the lamp source for heat exchange then enters the drainage channel for buffering, and is then extracted through the exhaust device arranged on the rear side of the detection box. On the one hand, the air flow path can be made clear, and the heat can be efficiently brought out of the channel, avoiding heat accumulation in the channel; and due to the design of the acceleration section of the channel and the straight structure of the channel itself with an empty middle, the hot air will not form complex eddies or reflux phenomena in the channel, thereby ensuring the continuity and effectiveness of heat dissipation.

[0040] In some embodiments, see Fig.17 , the inner diameter of the drainage channel from the first end to the second end changes from large to small and then becomes large, so that the drainage channel is divided into a gathering section 141, an acceleration section 142 and a buffer section 143 from its first end to the second end, and the inner diameter of the acceleration section 142 is smaller than the inner diameter of the gathering section 141 and the inner diameter of the buffer section 143. Among them, the first end of the drainage channel is close to the end of the suction device, and the second end of the drainage channel is close to the end of the exhaust device, that is, the inner diameters of the two ends of the drainage channel are larger than the inner diameter of the middle part, so that an acceleration section is formed in the middle part of the drainage channel. Of course, the inner diameter here can also be the width or length. In short, the cross-sectional area of ​​the channel of the acceleration section is smaller than the cross-sectional area of ​​the channel of the gathering section and the buffer section.

[0041] In some embodiments, the ratio of the inner diameter of the acceleration section to the inner diameters of the two ends of the drainage channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the drainage channel gradually shrink inward, so that the cross-sectional area of ​​the middle section (acceleration section) is reduced to 40%-60% (preferably 50%) of the two ends.

[0042] In some embodiments, the inner diameters of the two ends of the drainage channel, i.e., the first end of the gathering section and the first end of the buffer section, are respectively the same as the inner diameters of the second end of the cooling zone and the first end of the heat dissipation zone, so that the drainage channel has a smooth transition with the cooling zone and the heat dissipation zone, respectively.

[0043] In some embodiments, the acceleration section is divided into multiple sections, and the reduction section 1421 and the recovery section 1422 are used alternately. The inner diameter of the reduction section 1421 is smaller than the inner diameter of the recovery section 1422, so that after the hot air enters the acceleration section (a longer channel), it can avoid the high pressure loss caused by the long channel, thereby ensuring that a continuous negative pressure can be formed in the gathering section. In some specific embodiments, After the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the negative pressure formed by the acceleration of the acceleration section in the gathering section quickly draws the hot air to the gathering section for gathering, so as to prevent the hot air after heat exchange from mixing with the cold air newly entering the cooling zone and reducing the heat dissipation effect, thereby ensuring that the air around the lamp source has a large temperature difference with the lamp source. Then the hot air gathered in the gathering section immediately enters the acceleration section for rapid discharge, and enters the buffer section for temporary storage. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the outside, and on the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameters between the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, the present application provides a "rapid drainage anti-backflow heat dissipation structure".

[0044] Herein, the first side 401 (i.e., the front side, the side for user operation), the second side 402, the third side 403 (i.e., the rear side), and the fourth side 404 of the housing can be referred to as Figure 6 Specifically, the side where the detection space is provided is the first side 401, the side where the air inlet is provided is the second side 402, the side where the air outlet is provided is the third side 403, and the side close to the detection element is the fourth side 404; that is, the first side 401 and the third side 403 are arranged opposite to each other, and the second side 402 and the fourth side 404 are arranged opposite to each other.

[0045] In some embodiments, see Fig. 9 The two sides of the partition 5 that contact the bottom wall of the shell extend to both sides of the heat dissipation space to form curling edges 51 parallel to the bottom wall. At least two clamping blocks 44 are provided on the bottom wall. When the two curling edges 51 are fixed by the at least two clamping blocks 44, the curling edges 51 are attached to the bottom wall. By providing the curling edges and the clamping blocks on the bottom wall for clamping and fixing, while achieving quick disassembly and assembly, the curling edges attached to the bottom wall can also further improve the sealing of the heat dissipation space.

[0046] In other embodiments, see Fig.11 The two side edges of the partition 5 that contact the bottom wall of the shell extend to both sides of the heat dissipation space to form curled edges parallel to the bottom wall. At least one through hole is provided on the curled edge. Correspondingly, at least one threaded hole corresponding to the through hole is provided on the bottom wall. When the bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition to the bottom wall, and the curled edge is attached to the bottom wall, that is, at this time, the curled edge is parallel to the bottom wall.

[0047] In some embodiments, see Figure 2 The air inlet is arranged on one of the side walls of the first end of the partition, and correspondingly, the air inlet hole 411 is arranged on the second side of the shell 41.

[0048] In other embodiments, see Figure 5 There are two air inlets, which are respectively located on the top and one of the side walls of the partition; correspondingly, there are also two air inlet holes 411, which are respectively located on the top and the second side of the shell.

[0049] In some embodiments, the detection space is formed by an outer surface of the first side of the housing being recessed inwardly, and a sample detection area corresponding to the opening and an installation area for installing a water conduit are provided in the detection space.

[0050] In some embodiments, the sample detection area is provided with a movable window, and during the detection process, the movable window is in a closed state; the user can inspect or replace the light source located inside the shell by opening the movable window.

[0051] In some embodiments, the partition is disposed close to the second side of the shell, and the detection element is disposed close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0052] In some specific embodiments, the detection box is divided into two parts, the light source and the sample detection area are both located in the left half, and accordingly, the partition is also arranged in the left half; and the detection elements (such as sensors, data acquisition and processing units, signal amplifiers, etc.) and the water pipe are arranged in the right half, preferably at the rightmost end of the detection box, that is, the end away from the light source, so as to separate the light source from other elements, thereby minimizing or avoiding the heat generated by the light source from being conducted to other components such as the detection elements and the water pipe, resulting in inaccurate measurement results or component aging problems.

[0053] In some embodiments, see Fig.10 and Fig.11 , heat insulation cotton 12 is arranged on the partition (preferably the top).

[0054] In some embodiments, see Fig.14 The chromatograph further comprises a water guide assembly, which comprises a water guide pipe 9 and a water guide column. The water guide column is arranged in the installation area, and the water guide pipe 9 is detachably connected to the water guide column.

[0055] In some embodiments, see Fig.12 and Fig.13 The installation area is provided with a limiting step 433, and the water guide column 8 is provided with a buckle 81. When the buckle 81 is buckled on the limiting step 433, the water guide column 8 is fixed on the housing 41. By arranging the external water guide pipe in a detachable manner, the water guide pipe can be quickly disassembled and assembled.

[0056] In some embodiments, see Fig.12 The installation area is provided with a plurality of limiting protrusions 434, which cooperate to form a limiting groove for fixing the water guide column 8. By fixing the pipe body of the water guide column through the limiting groove, the water guide column can be prevented from swinging in the detection space, thereby causing leakage.

[0057] In some embodiments, see Figure 3A water channel 10 is provided at the bottom of the detection space, and the height of the water channel 10 gradually decreases from the first end to the second end thereof, so that the water channel 10 forms an inclined drainage slope, and a waste liquid outflow port 11 is provided at the second end of the water channel 10. By providing an inclined drainage slope, it can be ensured that the waste liquid generated during the detection process can be quickly discharged.

[0058] In some embodiments, the infusion pump and the column temperature box are both provided with water guide columns and water guide tubes, and their specific structure and installation method can refer to the water guide tubes and water guide columns in the detection box, which will not be repeated here; wherein, the infusion pump, the column temperature box and the water guide tubes on the detection box are connected in sequence.

[0059] In some embodiments, a water channel is provided at the bottom of the infusion pump and the column temperature box, and the height of the water channel gradually decreases from the first end to the second end, so that the water channel forms an inclined drainage slope, and a waste liquid outflow outlet is provided at the second end of the water channel.

[0060] In some embodiments, the waste liquid outflow port is connected to the water inlet end of the water pipe, that is, the waste liquid outflow port on each of the infusion pump, the column temperature box and the detection box is connected to the water pipe arranged thereon, and the three water pipes are also connected in sequence.

[0061] In some embodiments, see Figure 2-Figure 4 , the infusion set, the column temperature box and the detection box are all provided with a magnetic suction door 45; Specifically, the first side of the infusion pump and the column thermostat are respectively provided with an installation space, and a plurality of the first magnetic elements 413 are provided on the installation space. The infusion pump and the column thermostat also include a magnetic door 45, and a plurality of second magnetic elements 451 corresponding to the first magnetic elements 413 are provided on the magnetic door 45; when the magnetic door 45 is installed on the infusion pump and / or the column thermostat through the second magnetic elements 451 and the first magnetic elements 413, the magnetic door 45 and the installation space are enclosed to form a closed space, and the water pipes of the infusion pump and the column thermostat are located in the closed space.

[0062] The detection space is provided with a plurality of first magnetic elements 413; the detection box further includes a magnetic door 45, on which a plurality of second magnetic elements 451 corresponding to the first magnetic elements 413 are provided; when the magnetic door 45 is mounted on the housing through the second magnetic elements 451 and the first magnetic elements 413, the housing and the magnetic door 45 enclose the closed detection space. That is, the magnetic door 45 blocks the opening of the detection space, making the detection space a closed space.

[0063] In some embodiments, the first magnetic element 413 and the second magnetic element 451 are both magnets.

[0064] In summary, the present application comprehensively provides a heat dissipation solution that limits heat to a limited area and quickly draws out the heat through a "DC" convection air duct; specifically, the present solution sets up a "DC" partitioned and isolated heat dissipation channel, cooperates with an air suction device and an exhaust device to synchronously introduce cold air into the heat dissipation space, and extracts hot air from the heat dissipation space, so that the air inside the heat dissipation space is quickly drained from its first end to the second end for discharge, thereby achieving rapid and centralized heat dissipation of the lamp source. On the one hand, a large amount of heat generated by the lamp source can be concentrated in the heat dissipation space, thereby preventing the heat from diffusing to the detection element or the area where the water pipe is located and causing adverse effects thereon; on the other hand, the drainage channel can buffer the heat, that is, the heat generated by the lamp source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessive temperature of the lamp source; further, the "DC" air duct design can make the airflow path clear, and thus can efficiently bring heat out of the channel, avoiding heat accumulation in the channel.

[0065] Embodiment 2 This embodiment is basically Fig.15 , Figure 19-22 As shown: See also Fig.15 The present embodiment provides a column oven for a liquid chromatograph, comprising a housing 300, and a heating device and a cooling device arranged inside the housing 300, a heat conducting portion 301 is arranged on a first side of the housing 300, the heating device is in surface contact with the heat conducting portion 301, a trapezoidal mounting piece 302 is arranged on a second surface of the heat conducting portion 301, a plurality of mounting grooves of different lengths are transversely arranged on the mounting piece 302, the cross-sectional shape of the mounting groove is an arc, the mounting groove passes through the mounting piece, and fixing clips are respectively arranged at both ends of the mounting groove; when a chromatographic column 303 is mounted on the fixing clip and fixed, the middle part of the chromatographic column 303 is located in the mounting groove and is wrapped, and the two ends of the chromatographic column 303 are located outside the mounting groove and suspended in the air.

[0066] By providing installation slots with different lengths, chromatographic columns with different lengths can be installed accordingly, and the multiple installation slots are arranged in a trapezoidal shape (hierarchical arrangement). No matter in which installation slot the chromatographic column is installed, it can be ensured that sufficient operating space is reserved on at least one side of the installation slot. For example, the end of the second installation slot from top to bottom, that is, the upper part of the two sides of the two fixing clips of the installation slot is unobstructed, thereby facilitating user operation.

[0067] Furthermore, the fixing clips are arranged at both ends of the mounting groove, which is easy to replace on the one hand, and on the other hand, during the specific operation, the user pinches the bolt (that is, the part with a larger diameter) and pushes the chromatographic column into the fixing clip to fix it, so that the chromatographic column can automatically dock with the mounting groove without repeated adjustment.

[0068] In some embodiments, a heat-conducting space is provided inside the shell, and the column oven also includes a heating device and a refrigeration device arranged in the heat-conducting space. An installation space for installing a chromatographic column is provided on one side of the shell, and the installation space corresponds to the heating part.

[0069] In some embodiments, see Fig. 22 The heating device includes a plurality of heating tubes 305 arranged inside the heat-conducting portion 301 or close to the heat-conducting portion 301, the number of the heating tubes 305 is the same as the number of the mounting slots (preferably 4 tubes / each), and the plurality of heating tubes 305 correspond to the plurality of mounting slots one by one; thereby, the heat conduction between the heat-conducting tube and the chromatographic column 303 is more uniform and direct. In other words, the heat of the heat-conducting tube can be firstly "directedly" conducted to the chromatographic column 303 through the heat-conducting portion 301 to achieve heating, rather than being indiscriminately conducted to various parts of the heat-conducting panel as in the prior art, thereby achieving the purpose of saving heat source.

[0070] In some embodiments, the refrigeration device and the heat conducting part 301 are installed in an intermittent contact manner. When the cold end 307 of the refrigeration device is in contact with the heat conducting part 301, the chromatographic column 303 can be cooled through the heat conducting part 301. When the refrigeration device leaves the first surface of the heat conducting part 301, the refrigeration device no longer cools the chromatographic column 303.

[0071] In some specific embodiments, the refrigeration device includes a cold end 307, a refrigeration plate 312, an elastic member 308 and a pull rod motor 309 connected in sequence, wherein the output end of the pull rod motor 309 is connected to the refrigeration plate 312 through the elastic member 308, the refrigeration plate 312 is arranged face to face with the cold end 307, and the cold end 307 corresponds to the heat conducting part 301 but does not contact it.

[0072] When the output end of the pull rod motor 309 is extended, the output end of the pull rod motor 309 drives the cooling plate 312 and the cold end 307 to move toward the direction close to the heat conducting part 301, so that the cold end 307 is close to the heat conducting part 301 and the elastic member 308 is compressed. The heat generated by the cooling plate 312 is transferred to the heat conducting part 301 through the cold end 307, and then transferred to the mounting part and the chromatographic column 303.

[0073] When the output end of the pull rod motor 309 contracts, the elastic member 308 is reset, driving the cooling plate 312 and the cold end 307 to reset, thereby making the cold end 307 no longer in contact with the heat conducting part 301 .

[0074] In this way, during the heating process, the refrigeration device is kept in a closed state, and the heat generated by the heating tube 305 will not be conducted to the refrigeration device to cause heat loss. Only when refrigeration is needed, the refrigeration end 307 is brought into contact with the heat conduction part 301 to achieve refrigeration. That is to say, the refrigeration device and the heating device in the present application are independently arranged, work independently of each other, and do not interfere with each other.

[0075] In some embodiments, the refrigeration device further includes heat sinks 310 disposed on both sides of the refrigeration fins 312 , and correspondingly, a heat dissipation fan 311 corresponding to the heat sink 310 is disposed on the housing.

[0076] In some embodiments, the heat conducting portion 301 is provided with a temperature sensor 306 .

[0077] In some embodiments, the lengths of the plurality of mounting slots increase sequentially from top to bottom.

[0078] In some embodiments, the mounting member is in the shape of an equilateral trapezoid, and a line connecting center points of the plurality of mounting slots is parallel to a height direction of the chromatograph.

[0079] In some embodiments, see Fig.21 The fixing clamp includes a connecting portion connected to the mounting member, and an upper clamp 341 and a lower clamp 342 symmetrically arranged on both sides of the connecting portion. The connecting portion, the upper clamp 341 and the lower clamp 342 enclose a clamping space 344. The upper clamp 341 and the lower clamp 342 can be deformed under the action of external force, and the connecting portion cannot be deformed.

[0080] In some embodiments, the upper clamping piece 341 and the lower clamping piece 342 extend outward away from one end of the connecting portion to form a guide space 343 with a gradually increasing height; When the chromatographic column enters the clamping space 344 along the guide space 343, the upper clamp 341 and the lower clamp 342 are deformed outward respectively, so that the clamping space 344 becomes larger. When the chromatographic column completely enters the clamping space 344, the upper clamp 341 and the lower clamp 342 are reset to clamp the chromatographic column.

[0081] Among them, the connecting part includes a base arranged in the vertical direction, the base gradually shrinks inward so that the height of the connecting part gradually decreases from the first end to the second end, the upper clamp and the lower clamp are connected to the second end of the connecting part, the clamping space is circular or elliptical with openings on both sides, and the diameter of the clamping space is greater than the height of the second end of the connecting part, and the guiding space is in the shape of a trumpet opening outward (principle of the clamping space).

[0082] The present application provides a guiding space with a positioning function, so that when the user pushes the chromatographic column into the clamping space, he only needs to roughly align the chromatographic column with the clamping space. Under the guidance of the guiding space, the chromatographic column can automatically enter the clamping space and be clamped.

[0083] In some embodiments, see Fig.19 The column temperature box also includes a water guide component arranged along the height direction of the column temperature box, and the water guide component includes a water guide column 8 and a flexible water guide tube 9. The first end of the water guide column 8 is provided with a water guide cavity, and the bottom of the water guide cavity is opened and extends downward to form a water guide channel passing through the water guide column. The first end of the water guide tube is detachably connected to the second end of the water guide column, so that the water guide tube is connected to the water guide channel.

[0084] In some embodiments, the detection box is provided with a water guide groove connected to the water guide cavity; so that the waste liquid generated in the detection box can be drained into the water guide cavity through the water guide groove and flow out through the water guide channel and the water guide pipe.

[0085] By arranging the external water pipe in a detachable manner, the water pipe can be quickly disassembled and assembled.

[0086] In summary, the present application comprehensively provides a surface-contact hierarchical fixed-point heating column oven, which can meet the installation and heating requirements of chromatographic columns of different lengths, is simple and convenient to use, and has high heating efficiency.

[0087] Embodiment 3 This embodiment is basically Figure 12-14 and Fig.19 As shown: This embodiment provides a liquid discharge system for a liquid chromatograph, wherein the chromatograph includes a tray, an infusion set, a column temperature box, and a detection box arranged in sequence from top to bottom. The specific structure of the chromatograph can refer to the structure of the chromatograph in the first embodiment.

[0088] The drainage system comprises three water-guiding components connected in sequence along the height direction of the chromatograph, and the three water-guiding components are respectively arranged on the infusion set, the column temperature box and the detection box; the three water-guiding components adopt the same structure.

[0089] Specifically, the water guide component includes a water guide column 8 and a flexible water guide pipe 9 (for example, a rubber hose), the first end of the water guide column 8 is provided with a water guide cavity 82, the bottom of the water guide cavity 82 is opened and extends downward to form a water guide channel 83 that passes through the water guide column 8, the first end of the water guide pipe 9 is detachably connected to the second end of the water guide column 8, so that the water guide pipe 9 is in communication with the water guide channel 83; wherein, the second end of the water guide column 8 refers to one end of the water guide cavity 82 described in principle.

[0090] The three water guide columns 8 are respectively fixed (including detachable fixing methods) on the infusion set, the column temperature box and the detection box, and the second end of the water guide tube 9 on the infusion set is connected to the water guide cavity 82 on the column temperature box, and the second end of the water guide tube 9 on the column temperature box is connected to the water guide cavity 82 on the detection box. In other words, the water guide tube 9 and the water guide column 8 of the same water guide component are detachably connected, and the internal connection forms a waste liquid channel, and the adjacent water guide components are connected to each other, so that the water guide components on the infusion set, the column temperature box and the detection box are connected in sequence to form a complete drainage system.

[0091] In some embodiments, the infusion pump, the column temperature box and the detection box are respectively provided with water guide grooves connected to the water guide cavity 82; so that the waste liquid generated in the infusion pump, the column temperature box and the detection box can be drained into the water guide cavity 82 through the water guide grooves, and flow out through the water guide channel 83 and the water guide pipe 9.

[0092] In some embodiments, the diameter of the water guiding cavity 82 is larger than the diameter of the pipe. When the second end of the pipe is connected to the water guiding cavity 82, a certain space is still left between the water guiding cavity 82 and the pipe, thereby facilitating the waste liquid in the water guiding groove to pass into the water guiding cavity 82.

[0093] In some embodiments, the height of the water guide groove gradually decreases from the first end to the second end to form an inclined slope, and the second end of the water guide groove is connected to the water guide cavity 82.

[0094] In some embodiments, the infusion pump, the column temperature box and the detection box are respectively provided with grooves 436 for accommodating the water guiding cavity 82, and a limiting step 433 is provided at the bottom of the groove 436; the water guiding cavity 82 is located in the groove 436, and the bottom of the water guiding cavity 82 is against the limiting step 433, and the second end of the water guiding column 8 extends out of the groove 436 and is located below the groove 436.

[0095] In some embodiments, a buckle 81 is provided at the bottom of the water guide column 8, and the buckle 81 and the bottom of the water guide groove are combined to form a slot, and the limiting step 433 is located in the slot. In other words, the water guide column 8 can be fixed in the water guide groove by snapping, and at this time, the slot can limit the water guide column 8 vertically, and the water guide groove can limit the water guide column 8 horizontally.

[0096] In some embodiments, at least two limiting protrusions 434 are respectively provided on the infusion set, the column temperature box and the detection box, and the two limiting protrusions 434 cooperate to form a limiting groove for lateral limiting of the water pipe 9. When the water pipe 9 is installed in the limiting groove, the two limiting protrusions 434 are respectively located on both sides of the water pipe 9 to prevent the water pipe 9 from lateral displacement.

[0097] In some embodiments, the bottom of the water guide cavity 82 extends downward to form a transition section 84 and a connecting section 85 in sequence; the diameter of the transition section 84 is larger than the diameter of the connecting section 85, and the water guide pipe 9 is sleeved on the connecting section 85. By providing the transition section 84, the stability of the water guide column 8 can be increased.

[0098] In some embodiments, the infusion set, the column temperature box and the detection box are respectively provided with limiting holes, the limiting holes are located below the groove 436, and the second end of the water guide column 8 extends out of the limiting hole and is located below the limiting hole. By providing the limiting holes, the water guide column 8 is "double-limited" at different heights, which can further prevent the water guide column 8 from lateral swinging.

[0099] In some embodiments, at least two of the limiting protrusions 434 are staggered along the height direction of the liquid chromatograph and are respectively located on both sides of the water conduit 9, so that grooves 435 are formed on both sides of the water conduit 9. For example, two limiting protrusions 434 are respectively arranged on both sides of the water conduit 9, a first groove 435 is formed between the limiting protrusions 434 on one side, and a second groove 435 is formed between the limiting protrusions 434 on the opposite side, and the first groove 435 and the second groove 435 have different heights, that is, the limiting protrusions 434 on both sides are staggered, and the two grooves 435 are also staggered, so that the user can pinch at least one side of the water conduit 9 from the slot part to take the water conduit 9 out of the limiting slot.

[0100] In some embodiments, the second end of the connecting section 85 extends downward, and the outer diameter gradually decreases to form a guiding slope, so as to facilitate the water guide pipe 9 to be inserted into the second end of the water guide column 8 along the guiding slope.

[0101] In summary, the present application provides an external split drainage pipe design with multiple limiting structures. Specifically, the water pipe is connected to the water guide column in a single-sided fixed manner, and both are restricted by multiple limiting structures. While ensuring the stability of the drainage system, the water pipe can be quickly disassembled and assembled.

[0102] First, the water guide column in the drainage system is fixed on the chromatograph, one end of the water guide tube is sleeved on one end of the water guide column, and the other end is connected to the water guide cavity but not fixed, that is, the water guide tube is installed in a single-sided fixed manner. On the one hand, it is convenient to replace the water guide tube. On the other hand, the water guide column is fixed on the chromatographic column. After the water guide tube is replaced, the water guide tube can be automatically aligned through the water guide column.

[0103] Furthermore, the present application sets up multiple limiting structures on the chromatograph. For example, through the cooperation of limiting steps and limiting holes, the water guide column can be horizontally limited; through limiting grooves, the water guide pipe can be horizontally limited, which can ensure that the water guide column and the water guide pipe always maintain a corresponding state, thereby ensuring the stability of the drainage system.

[0104] Furthermore, by providing an inclined drainage slope, it can be ensured that the waste liquid generated during the detection process can flow into the open water guide cavity to merge and be quickly discharged.

[0105] Embodiment 4 In the prior art, the heat dissipation method of the chromatograph is mostly to set an exhaust device on the side wall of the detection box to extract the hot air distributed inside the detection box, so as to achieve the purpose of heat dissipation. For example, the Chinese utility model patent with application number 202120699737.2 discloses an ion chromatograph; wherein, the lamp source (usually a deuterium lamp and a tungsten lamp, that is, a heat source) is exposed to the entire cavity of the detection box, and a large amount of heat generated by the lamp source will be quickly distributed to the entire cavity. For example, in the case of low ambient temperature such as cold storage, even if the heat is dissipated into the cavity, the heat in the cavity will exchange heat with the cold air in the environment, and the exhaust device arranged on the side wall of the detection box can basically achieve cooling in the cavity. However, this method has at least the following defects: for example, the heat generated by the lamp source is indiscriminately distributed throughout the entire cavity of the detection box. When the detection elements located in the cavity are heated, it is very likely that their measurement results will be inaccurate; for example, if some components in the detection box (such as the water pipe located in the detection cavity) are exposed to a high temperature environment for a long time, their aging will inevitably be accelerated.

[0106] In addition, if the ambient temperature is high (for example, in a general laboratory, especially in the case of power rationing in summer, the air conditioning temperature cannot be adjusted too low, and the indoor temperature is about 20-25°), if a large amount of heat is stored inside the cavity, and the heat in the cavity exchanges heat with the air in the environment at a slow rate, it is difficult for the exhaust device installed on the side wall of the test box to achieve rapid cooling in the cavity.

[0107] Based on the above background, this embodiment provides a detection box of a liquid chromatograph, see Figure 1 and Fig.10 , the detection box includes a shell 41, and a light source 46 and a detection element 42 arranged inside the shell 41; It also includes a partition 12 that is detachably arranged inside the shell 41, and a closed heat dissipation space enclosed around the lamp source 46 is formed between the partition 12 and the bottom wall of the shell 41 and the side wall of the first side of the shell 41, and the heat dissipation space extends from the first side to the third side of the shell; that is, the heat dissipation space is a straight channel, and the hot air in the heat dissipation space can be discharged directly from the first end to the second end thereof, and the heat dissipation efficiency is high.

[0108] See also Fig.16 The heat dissipation space is divided into a cooling zone 13, a drainage channel 14 and a heat dissipation zone 15 from the first end to the second end. An air inlet 52 is provided on at least one side wall of the cooling zone 13. An air suction device 6 is provided at the air inlet 52. The light source 46 is provided in the cooling zone 13 and corresponds to the air suction device 6. The heat dissipation zone 15 is provided with an air outlet 53 corresponding to the third side of the housing 41. An exhaust device 7 is provided at the air outlet 53. Accordingly, see Figure 5 , the shell is provided with at least one air inlet 411 corresponding to the air suction device, and an air outlet 412 corresponding to the air exhaust device. That is to say, the air inlet is provided on the side wall of the shell, and the air outlet is provided on the rear side of the shell, which will not affect the user's operation; that is, the air inlet and the air outlet are respectively located at the two ends of the heat dissipation space, and the heat dissipation space runs through the entire shell.

[0109] In some embodiments, two air inlets are provided, and the two air inlets are respectively located at the top and the second side of the partition.

[0110] In some embodiments, see Fig.11 The partition is an N-shaped partition with openings at both ends. A mounting plate 54 is provided at the opening of the second end of the partition. The exhaust device is provided on the mounting plate 54. When the partition 5 and the mounting plate 54 are installed in the shell 41, the partition 5, the mounting plate 54 and the bottom wall of the shell 41 and the side wall of the first side enclose a heat dissipation space.

[0111] In some embodiments, the air suction device and the air exhaust device are both fans (preferably silent fans).

[0112] The present application corresponds the lamp source (also known as the heat source) to the cooling zone, and the cold air sucked in by the suction device is directly blown onto the lamp source, which can directly and quickly cool it down. The hot air generated by the cold air blowing through the lamp source for heat exchange then enters the drainage channel for buffering, and is then extracted through the exhaust device arranged on the rear side of the detection box. On the one hand, the air flow path can be made clear, and the heat can be efficiently brought out of the channel, avoiding heat accumulation in the channel; and due to the design of the acceleration section of the channel and the straight structure of the channel itself with an empty middle, the hot air will not form complex eddies or reflux phenomena in the channel, thereby ensuring the continuity and effectiveness of heat dissipation.

[0113] In some embodiments, see Fig.17 , the inner diameter of the drainage channel from the first end to the second end changes from large to small and then becomes large, so that the drainage channel is divided into a gathering section 141, an acceleration section 142 and a buffer section 143 from its first end to the second end, and the inner diameter of the acceleration section 142 is smaller than the inner diameter of the gathering section 141 and the inner diameter of the buffer section 143. Among them, the first end of the drainage channel is close to the end of the suction device, and the second end of the drainage channel is close to the end of the exhaust device, that is, the inner diameters of the two ends of the drainage channel are larger than the inner diameter of the middle part, so that an acceleration section is formed in the middle part of the drainage channel. Of course, the inner diameter here can also be the width or length. In short, the cross-sectional area of ​​the channel of the acceleration section is smaller than the cross-sectional area of ​​the channel of the gathering section and the buffer section.

[0114] In other words, in some embodiments, the inner diameter of the gathering section gradually decreases from the first end to the second end, and the inner diameter of the buffer section gradually increases from the first end to the second end, so that the drainage channel is similar to an X-shape. That is, the diameter of the middle part of the drainage channel is small, and the two ends extend to both sides respectively and the inner diameter gradually increases. The drainage channel is similar to an X-shape, but not completely X-shaped. The middle part is not closed, and the gathering section and the buffer section can be a slope or an arc shape. Of course, the inner diameter here can also be the width or length. In short, the cross-sectional area of ​​the channel of the acceleration section is smaller than the cross-sectional area of ​​the channel of the gathering section and the buffer section. Among them, the first end of the drainage channel is close to the end of the suction device, and the second end of the drainage channel is close to the end of the exhaust device.

[0115] In some embodiments, the ratio of the inner diameter of the acceleration section to the inner diameters of the two ends of the drainage channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the drainage channel gradually shrink inward, so that the cross-sectional area of ​​the middle section (acceleration section) is reduced to 40%-60% (preferably 50%) of the two ends.

[0116] In some embodiments, the inner diameters of the two ends of the drainage channel, i.e., the first end of the gathering section and the first end of the buffer section, are respectively the same as the inner diameters of the second end of the cooling zone and the first end of the heat dissipation zone, so that the drainage channel has a smooth transition with the cooling zone and the heat dissipation zone, respectively.

[0117] In some embodiments, the acceleration section is divided into multiple sections, and the reduction section 1421 and the recovery section 1422 are used alternately. The inner diameter of the reduction section 1421 is smaller than the inner diameter of the recovery section 1422, so that after the hot air enters the acceleration section (a longer channel), it can avoid the high pressure loss caused by the excessive length of the channel, thereby ensuring that a continuous negative pressure can be formed in the gathering section.

[0118] In some specific embodiments, after the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the negative pressure formed by the acceleration effect of the acceleration section in the gathering section quickly draws the hot air to the gathering section for gathering, so as to prevent the hot air after heat exchange from mixing with the cold air newly entering the cooling zone and reducing the heat dissipation effect, thereby ensuring that the air around the lamp source has a large temperature difference with the lamp source. Then, the hot air gathered in the gathering section immediately enters the acceleration section and quickly enters the buffer section for discharge. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the outside. On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameters between the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, the present application provides a "rapid drainage anti-backflow heat dissipation structure".

[0119] In some embodiments, the partition is disposed close to the second side of the shell, and the detection element is disposed close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0120] In some specific embodiments, the detection box is divided into two parts, the light source and the sample detection area are both located in the left half, and accordingly, the partition is also arranged in the left half; and the detection elements (such as sensors, data acquisition and processing units, signal amplifiers, etc.) and the water pipe are arranged in the right half, preferably at the rightmost end of the detection box, that is, the end away from the light source, so as to separate the light source from other elements, thereby minimizing or avoiding the heat generated by the light source from being conducted to other components such as the detection elements and the water pipe, resulting in inaccurate measurement results or component aging problems.

[0121] In some embodiments, see Fig. 9 The two sides of the partition 5 that contact the bottom wall of the shell extend to both sides of the heat dissipation space to form curling edges 51 parallel to the bottom wall. At least two clamping blocks 44 are provided on the bottom wall. When the two curling edges 51 are fixed by the at least two clamping blocks 44, the curling edges 51 are attached to the bottom wall. By providing the curling edges and the clamping blocks on the bottom wall for clamping and fixing, while achieving quick disassembly and assembly, the curling edges attached to the bottom wall can also further improve the sealing of the heat dissipation space.

[0122] In other embodiments, see Fig.11 The two side edges of the partition 5 that contact the bottom wall of the shell extend to both sides of the heat dissipation space to form curled edges parallel to the bottom wall. At least one through hole is provided on the curled edge. Correspondingly, at least one threaded hole corresponding to the through hole is provided on the bottom wall. When the bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition to the bottom wall, and the curled edge is attached to the bottom wall, that is, at this time, the curled edge is parallel to the bottom wall.

[0123] In some embodiments, the first end of the partition is provided with an opening corresponding to the first side of the shell; A detection space is provided outside the shell, the detection space is located on the first side of the shell, the detection space includes a sample detection area and an installation area, the sample detection area is provided with an inspection window corresponding to the opening, and the installation area is detachably provided with a water conduit.

[0124] In some embodiments, a plurality of first magnetic elements are disposed on the shell; the detection box further comprises a magnetic suction door, and a plurality of second magnetic elements corresponding to the first magnetic elements are disposed on the magnetic suction door; When the magnetic door is installed on the housing through the second magnetic element and the first magnetic element, the housing and the magnetic door enclose the closed detection space. By setting a magnetic door, the airtightness of the detection space can be greatly improved compared with a traditional hinged door.

[0125] In summary, the present application comprehensively provides a fixed-point heat dissipation solution that limits the large amount of heat generated by the lamp source to a limited area and quickly draws the heat out by setting a guiding path, namely a "DC" convection air duct.

[0126] Specifically, the present solution sets a heat dissipation space extending from the first side to the third side of the shell, cooperates with the suction device and the exhaust device respectively located on both sides of the heat dissipation space, so as to simultaneously introduce cold air into the heat dissipation space and extract hot air from the heat dissipation space, so that the air inside the heat dissipation space is quickly drained from its first end to the second end for discharge, thereby realizing rapid and centralized heat dissipation of the lamp source. On the one hand, a large amount of heat generated by the lamp source can be concentrated in the heat dissipation space, thereby preventing the heat from diffusing outside the heat dissipation space and causing adverse effects on the detection elements in the shell or the area where the water pipes on the shell are located; on the other hand, the drainage channel can buffer the heat, that is, the heat generated by the lamp source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessive temperature of the lamp source; and the "direct current" air duct design can make the airflow path clear, thereby being able to efficiently bring the heat out of the channel, avoiding heat accumulation in the channel.

[0127] Furthermore, based on the fact that the drainage channel is relatively long (i.e., it runs through the entire shell), the present application divides the drainage channel into a plurality of functional zones with different inner diameters. During operation of the chromatograph, after the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the lamp source, the acceleration effect of the acceleration section causes the gathering section to form a negative pressure, thereby quickly leading the hot air to the gathering section for gathering, so as to prevent the hot air after the heat exchange from mixing with the cold air newly entering the cooling zone, thereby reducing the heat dissipation effect, thereby ensuring that the air around the lamp source has a large temperature difference with the lamp source. Then, the hot air gathered in the gathering section immediately enters the acceleration section and is quickly discharged to the buffer section, and then is discharged under the action of the exhaust device. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the cavity (i.e., other areas outside the heat dissipation space in the shell). On the other hand, it can facilitate the exhaust device located at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in the inner diameters of the acceleration section and the buffer section, it can also effectively prevent the hot air at the second end of the heat dissipation space from flowing back to the first end. In other words, the present application also provides a "rapid drainage anti-backflow heat dissipation structure".

[0128] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0129] The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A liquid chromatograph, characterized in that: The invention comprises a tray, an infusion set, a column temperature box and a detection box arranged in sequence from top to bottom; the detection box comprises a shell, and a light source and a detection element arranged inside the shell, a detection space is arranged on a first side of the shell, and the detection space is located outside the shell; A partition is detachably provided inside the shell, and a closed heat dissipation space enclosed around the lamp source is formed between the partition, the bottom wall of the shell, and the side wall of the first side of the shell, and the heat dissipation space extends from the first side to the third side of the shell; The heat dissipation space is divided into a cooling zone, a drainage channel and a heat dissipation zone in sequence from the first end to the second end. An air inlet is arranged on at least one side wall of the cooling zone, and an air suction device is arranged at the air inlet. The light source is arranged in the cooling zone corresponding to the air suction device; the heat dissipation zone is provided with an air outlet corresponding to the third side of the shell, and an exhaust device is arranged at the air outlet; accordingly, at least one air inlet corresponding to the air suction device and an exhaust hole corresponding to the exhaust device are respectively arranged on the shell.

2. A liquid chromatograph according to claim 1, characterized in that: The drainage channel is divided into a gathering section, an acceleration section and a buffer section from the first end to the second end thereof, and the inner diameter of the acceleration section is smaller than the inner diameters of the gathering section and the buffer section.

3. A liquid chromatograph according to claim 1, characterized in that: There are two air inlets, which are respectively located on the top of the partition and one of the side walls.

4. A liquid chromatograph according to claim 1, characterized in that: The detection space is formed by the outer surface of the first side of the shell being recessed inwardly, and a sample detection area corresponding to the opening and an installation area for installing a water pipe are arranged in the detection space.

5. A liquid chromatograph according to claim 4, characterized in that: The chromatograph further comprises a water guide assembly, wherein the water guide assembly comprises a water guide pipe and a water guide column, wherein the water guide column is arranged in the installation area, and the water guide pipe is detachably connected to the water guide column.

6. A liquid chromatograph according to any one of claims 1 to 5, characterized in that: The detection space is provided with a plurality of first magnetic elements; the detection box further comprises a magnetic suction door, and the magnetic suction door is provided with a plurality of second magnetic elements corresponding to the first magnetic elements; When the magnetic door is installed on the shell through the second magnetic element and the first magnetic element, the shell and the magnetic door enclose the closed detection space.

7. A liquid chromatograph according to claim 1, characterized in that: A water guide groove is arranged at the bottom of the detection space, and the height of the water guide groove gradually decreases from the first end to the second end thereof, so that the water guide groove forms an inclined drainage slope, and a waste liquid outflow outlet is arranged at the second end of the water guide groove.

8. A liquid chromatograph according to claim 1, characterized in that: The partition is arranged close to the second side of the shell, and the detection element is arranged close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

9. A liquid chromatograph according to claim 1, characterized in that: The infusion pump and the column temperature box are both provided with a water guide groove at the bottom, and the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and the second end of the water guide groove is provided with a waste liquid outflow outlet.

10. A liquid chromatograph according to claim 1, characterized in that: Two side edges of the partition plate in contact with the bottom wall of the shell extend toward both sides of the heat dissipation space to form curling edges parallel to the bottom wall, and at least two clamping blocks are provided on the bottom wall; When the two curling edges are fixed respectively by the at least two clamping blocks, the curling edges are attached to the bottom wall.

Images