A liquid chromatograph

Abstract

The application belongs to the technical field of substance analysis instruments, and particularly relates to a liquid chromatograph, which comprises, from top to bottom, a tray, a liquid feeder, a column temperature box and a detection box; the detection box comprises a shell, a lamp source and a detection element arranged in the shell, a detection space is arranged on the first side of the shell, the detection space is located outside the shell, a partition plate is detachably arranged in the shell, the partition plate and the bottom wall of the shell and the side wall of the first side of the shell form a closed heat dissipation space around the lamp source, and the heat dissipation space extends along the first side to the third side of the shell. Through the above structure, the application comprehensively provides a heat dissipation scheme for limiting heat to a limited area and quickly leading out heat through a "straight-flow type" convection air duct.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of substance analysis instruments, and particularly relates to a liquid chromatograph. BACKGROUND

[0002] A liquid chromatograph is an analytical instrument widely used in fields such as chemical analysis, biomedical science, and environmental monitoring. It separates and detects samples in a mobile phase to achieve qualitative and quantitative analysis of each component in a complex mixture. In a liquid chromatograph, an ultraviolet detector is one of the most commonly used detection methods, and the light source (i.e., the light source) of the ultraviolet detector usually uses a deuterium lamp and a tungsten lamp.

[0003] Among them, the deuterium lamp can provide a continuous ultraviolet spectrum of 190-400 nm, suitable for detecting compounds with strong ultraviolet absorption; the tungsten lamp is mainly used for detection in the visible light region (400-700 nm). However, these two types of lamps generate a large amount of heat during operation, and their operating temperatures are usually high. For example, the operating temperature of a deuterium lamp can reach more than 200°C, and the operating temperature of a tungsten lamp can also reach several hundred degrees Celsius.

[0004] In a high-temperature environment, the heat dissipation of the light source becomes one of the key factors affecting the performance of the liquid chromatograph. If the heat dissipation effect is poor, the following problems may occur:

[0005] Shortened lamp life: High temperatures can accelerate the aging and evaporation of the filament, reducing the service life of the light source.

[0006] Reduced detection accuracy: Temperature changes can affect the light intensity and wavelength stability of the light source, affecting the accuracy and repeatability of the detection results.

[0007] Increased risk of instrument failure: Excessive temperature can damage other components inside the detector, affecting the normal operation of the instrument.

[0008] Therefore, how to effectively solve the heat dissipation problem of the light source in the liquid chromatograph is of great significance to improve the performance and reliability of the instrument. At present, although some heat dissipation technologies have been applied to liquid chromatographs on the market, these technologies still have problems such as low heat dissipation efficiency, complex structure, and high cost. Therefore, developing a high-efficiency, stable, and low-cost heat dissipation device has important research value and application prospects for improving the overall performance of the liquid chromatograph. SUMMARY

[0009] The purpose of the present application is to provide a liquid chromatograph to ensure the working independence between the various components of the chromatograph and improve the stability of the chromatograph.

[0010] To solve the above-mentioned technical problems, the present application specifically adopts the following technical solutions:

[0011] A liquid chromatograph comprising a tray, an infusion pump, a column oven, and a detection box arranged in order from top to bottom; the detection box comprising a housing, a light source and a detection element disposed within the housing, a detection space disposed on a first side of the housing, and the detection space being located outside the housing;

[0012] A partition is detachably provided inside the housing, and a closed heat dissipation space surrounding the lamp source is formed between the partition, the bottom wall of the housing, and the side wall of the first side of the housing, and the heat dissipation space extends from the first side to the third side of the housing;

[0013] The heat dissipation space is divided into a cooling zone, a drainage channel and a heat dissipation zone from its first end to its second end. An air inlet is provided on at least one side wall of the cooling zone, and a suction device is provided at the air inlet. The light source is provided in the cooling zone corresponding to the suction device; the heat dissipation zone is provided with an air outlet corresponding to the third side of the shell, and an exhaust device is provided at the air outlet; accordingly, at least one air inlet corresponding to the suction device and an exhaust hole corresponding to the exhaust device are respectively provided on the shell.

[0014] As an improvement, the drainage channel is divided into a gathering section, an acceleration section and a buffer section from its first end to its second end, and the inner diameter of the acceleration section is smaller than the inner diameters of the gathering section and the buffer section.

[0015] As an improvement, two air inlets are provided, and the two air inlets are respectively located on the top of the partition and one of the side walls.

[0016] As an improvement, the detection space is formed by an inward depression of the outer surface of the first side of the shell, and a sample detection area corresponding to the opening and an installation area for installing the water pipe are provided in the detection space.

[0017] As an improvement, the chromatograph further includes a water guide assembly, which includes a water guide pipe and a water guide column. The water guide column is arranged in the installation area, and the water guide pipe and the water guide column are detachably connected.

[0018] As an improvement, a plurality of first magnetic elements are provided on the detection space; the detection box further comprises a magnetic door, and a plurality of second magnetic elements corresponding to the first magnetic elements are provided on the magnetic door;

[0019] When the magnetic door is mounted on the housing through the second magnetic element and the first magnetic element, the housing and the magnetic door enclose the closed detection space.

[0020] As an improvement, the detection space bottom is provided with a water guide groove, the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and the second end of the water guide groove is provided with a waste liquid outlet.

[0021] As an improvement, the partition plate is arranged close to the second side of the shell, and the detection element is arranged close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0022] As an improvement, the water guide groove is arranged at the bottom of the column oven and the infusion device, the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and the second end of the water guide groove is provided with a waste liquid outlet.

[0023] As an improvement, the two sides of the partition plate in contact with the bottom wall of the shell extend to both sides of the heat dissipation space to form a hem parallel to the bottom wall, and at least two clamping blocks are arranged on the bottom wall; when the two hems are fixed by the at least two clamping blocks respectively, the hems are attached to the bottom wall.

[0024] The principles and beneficial technical effects of the present application are:

[0025] In the prior art, the heat dissipation mode of the chromatograph is to arrange an air exhaust device on the side wall of the detection box to exhaust the hot air distributed in the detection box without distinction, so as to achieve heat dissipation. For example, the ion chromatograph disclosed in the Chinese utility model patent with application number 202120699737.2; wherein the light source (usually refers to deuterium lamp and tungsten lamp, i.e. heat source) is exposed to the entire cavity of the detection box, and a large amount of heat generated by the light source will be quickly distributed to the entire cavity. In the case of low ambient temperature such as cold storage, even if the heat is distributed to the inside of the cavity, the heat exchange between the heat in the cavity and the cold air in the environment can basically realize the cooling of the cavity with the air exhaust device arranged on the side wall of the detection box. However, if the ambient temperature is high (for example, the indoor temperature is about 20-25° in the general laboratory, especially in the summer power limiting situation, the air conditioner temperature cannot be adjusted too low), at this time, if a large amount of heat is stored in the cavity, and the heat exchange speed between the heat in the cavity and the air in the environment is slow, the air exhaust device arranged on the side wall of the detection box is difficult to realize the rapid cooling of the cavity.

[0026] In view of the above situation, the present application provides a fixed-point heat dissipation scheme which limits a large amount of heat generated by the light source to a limited area and quickly leads the heat out through the set guide path, i.e. "straight flow" convection air duct.

[0027] Specifically, the scheme is provided with a heat dissipation space extending along the first side to the third side of the shell, and air suction and exhaust devices are arranged on both sides of the heat dissipation space, so that cold air is introduced into the heat dissipation space and hot air is exhausted from the heat dissipation space, so that the air in the heat dissipation space is quickly drained from the first end to the second end for discharge, thereby realizing rapid and concentrated heat dissipation of the light source. On the one hand, a large amount of heat generated by the light source can be concentrated in the heat dissipation space, thereby preventing the heat from spreading outside the heat dissipation space and adversely affecting the detection elements in the shell or the area where the water guide pipe is located on the shell. On the other hand, the drainage channel can buffer the heat, that is, the heat generated by the light source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessively high temperature of the light source. Moreover, the "straight-flow" air duct design can make the airflow path clear, thereby efficiently taking out the heat from the channel and avoiding the accumulation of heat in the channel.

[0028] Further, based on the fact that the drainage channel is relatively long (i.e., it penetrates through the entire shell), the present application divides the drainage channel into multiple functional zones with different inner diameters. During the operation of the chromatograph, cold air enters the first end of the heat dissipation space into the cooling zone and exchanges heat with the light source. The acceleration of the acceleration section causes the accumulation section to form a negative pressure, thereby quickly guiding the hot air to the accumulation section for accumulation. This prevents the mixed heat exchange of the hot air and the newly entered cold air in the cooling zone, reduces the heat dissipation effect, and ensures that the air around the light source has a large temperature difference with the light source. Then, the hot air accumulated in the accumulation section is quickly discharged to the buffer section through the acceleration section, and then discharged under the action of the exhaust device. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the cavity (i.e., other areas outside the heat dissipation space in the shell). On the other hand, it can facilitate the exhaust device at the second end of the heat dissipation space to discharge the hot air. Furthermore, due to the difference in inner diameters of the acceleration section and the buffer section, the hot air at the second end of the heat dissipation space can also be effectively prevented from flowing back to the first end. That is, the present application also provides a "quick drainage anti-backflow heat dissipation structure". BRIEF DESCRIPTION OF DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. In all the drawings, similar elements or parts are generally identified by similar reference signs. In the drawings, each element or part is not necessarily drawn according to the actual proportion. Obviously, the drawings described below are some embodiments of the present application, and those skilled in the art can obtain other drawings according to these drawings without creating any inventive effort.

[0030] Figure 1 The overall structure of the chromatograph in the embodiments of the present application is shown in the schematic diagram.

[0031] Figure 2 Structure diagram of the detection box in an exemplary embodiment of the present application;

[0032] Figure 3 Structure diagram of the detection box in another exemplary embodiment of the present application;

[0033] Figure 4 Structure diagram of the magnetic door in an embodiment of the present application;

[0034] Figure 5 Another angle diagram of the detection box in an embodiment of the present application;

[0035] Figure 6 Diagram showing four side surfaces of the detection box in an embodiment of the present application;

[0036] Figure 7 Structure diagram of the detection box in an embodiment of the present application;

[0037] Figure 8 Structure diagram of the detection box in an embodiment of the present application;

[0038] Figure 9 Partial diagram of the detection box in an embodiment of the present application;

[0039] Figure 10 Another partial diagram of the detection box in an embodiment of the present application;

[0040] Figure 11 Exploded diagram of the internal structure of the detection box in an embodiment of the present application;

[0041] Figure 12 Structure diagram of the installation of the water guide pipe in an embodiment of the present application;

[0042] Figure 13 Partial structure diagram of the installation of the water guide pipe in an embodiment of the present application;

[0043] Figure 14 Structure diagram of the installation relationship between the water guide pipe and the water guide column in an embodiment of the present application;

[0044] Figure 15 Partial structure diagram of the column temperature box in an embodiment of the present application;

[0045] Figure 16 Structure diagram of the partition of the heat dissipation space in an embodiment of the present application;

[0046] Figure 17 Structure diagram of the internal structure of the drainage channel in an embodiment of the present application;

[0047] Figure 18The internal structure diagram of another exemplary drainage channel in the embodiment of the present application;

[0048] Figure 19 The exploded view of the liquid drainage system in the embodiment of the present application;

[0049] Figure 20 The partial side view of the column oven in the embodiment of the present application;

[0050] Figure 21 The partial diagram showing the fixing clamp structure in the column oven in the embodiment of the present application;

[0051] Figure 22 The sectional view of the column oven in the embodiment of the present application.

[0052] Marked in the figure: 1, tray; 2, infusion device; 3, column oven; 300, housing; 301, heat-conducting part; 302, mounting piece; 303, chromatographic column; 304, fixing clamp; 341, upper clamp piece; 342, lower clamp piece; 343, guiding space; 344, clamping space; 345, connecting part; 305, heating tube; 306, temperature sensor; 307, cold end; 308, elastic piece; 309, pull rod motor; 310, heat dissipation fin; 311, heat dissipation fan; 312, refrigeration fin; 4, detection box; 401, first side; 402, second side; 403, third side; 404, fourth side; 41, housing; 411, air inlet hole; 412, air outlet hole; 413, first magnetic element; 42, detection element; 43, detection space; 431, sample detection area; 432, mounting area; 433, limiting step; 434, limiting protrusion; 435, slot; 436, groove; 44, clamping block; 45, magnetically attracted door; 451, second magnetic element; 46, light source; 5, baffle; 51, hem; 52, air inlet; 53, air outlet; 54, mounting plate; 6, air suction device; 7, air exhaust device; 8, water guide column; 81, buckle; 82, water guide cavity; 83, water guide channel; 84, transition section; 85, connecting section; 9, water guide pipe; 10, water guide groove; 11, waste liquid outlet; 12, heat insulation cotton; 13, cooling area; 14, drainage channel; 141, gathering section; 142, accelerating section; 1421, narrowing section; 1422, recovery section; 143, buffer section; 15, heat dissipation area; 16, maintenance window. DETAILED DESCRIPTION

[0053] In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are some but not all of the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0054] Herein, the suffix such as "module", "part" or "unit" used for representing an element is only for facilitating the description of the present application, and has no specific meaning by itself. Therefore, "module", "part" or "unit" can be mixedly used. Herein, the terms "upper", "lower", "inner", "outer", "front", "back", "one end", "the other end" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0055] Herein, unless explicitly specified and limited, the terms "mount", "provided with", "connected" and the like should be understood broadly, for example, "connected" can be fixedly connected, or detachably connected, or integrally connected; can be mechanically connected, can be directly connected, or indirectly connected through an intermediate medium, can be the communication inside two elements. For a person of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances. Herein, "a plurality of" means two or more, that is, it includes two, three, four, five and the like.

[0056] Embodiment one

[0057] In the prior art, the heat dissipation mode of the chromatograph is to set an air extraction device on the side wall of the detection box to extract the hot air distributed in the interior of the detection box, so as to achieve the purpose of heat dissipation. For example, the ion chromatograph disclosed in the Chinese utility model patent with the application number 202120699737.2; wherein, the light source (usually refers to deuterium lamp and tungsten lamp, that is, heat source) is exposed to the entire cavity of the detection box, and a large amount of heat generated by the light source will be quickly distributed to the entire cavity. In the case of low ambient temperature such as cold storage, even if the heat is distributed to the interior of the cavity, the heat in the cavity exchanges heat with the cold air in the environment, and the air extraction device arranged on the side wall of the detection box can also basically realize the cooling of the cavity. However, this method at least has the following defects: for example, the heat generated by the light source is distributed to the entire cavity of the detection box without distinction, and after the detection element in the cavity is heated, it is extremely likely to cause inaccurate measurement results; for another example, if some elements (such as water guide pipe located in the detection cavity) in the detection box are exposed to a high-temperature environment for a long time, the aging of the elements will inevitably be accelerated.

[0058] In addition, if the ambient temperature is high (for example, in a general laboratory, especially in the case of summer power rationing, the air conditioner temperature cannot be adjusted too low, at this time the indoor temperature is about 20-25°), at this time if a large amount of heat is stored in the cavity, and the heat exchange speed between the heat in the cavity and the air in the environment is slow, the air extraction device arranged on the side wall of the detection box is difficult to realize the rapid cooling of the cavity.

[0059] The present application comprehensively provides a fixed-point heat dissipation scheme which limits a large amount of heat generated by the light source to a limited area and quickly leads out the heat through the set guide path, that is, the "straight-flow" convection air duct.

[0060] Specifically, the embodiment is basically as shown in the accompanying drawings: Figures 1-17

[0061] Referring to Figure 1 , the present application provides a liquid chromatograph, which comprises a tray 1, a liquid feeder 2, a column oven 3 and a detection box 4 arranged in sequence from top to bottom.

[0062] In some embodiments, referring to Figure 15 ​The column temperature box comprises a heat-conducting space for mounting a heating device and a refrigerating device, and a mounting space for mounting a chromatographic column, a heat-conducting part 301 is arranged between the heat-conducting space and the mounting space, the heat-conducting space and the mounting space are separated by the heat-conducting part 301, the mounting part 302 is arranged on the side close to the mounting space, a plurality of clamping grooves with different lengths are arranged on the mounting part 302, and the chromatographic column 303 can be clamped on the clamping grooves. It should be noted that the mounting part is also made of heat-conducting material, that is, the heat or cold source generated by the heating device or the refrigerating device in the heat-conducting space can be sequentially conducted to the chromatographic column through the heat-conducting part and the mounting part in a surface contact manner. Compared with the conventional heating mode by introducing hot air, the chromatographic column in the present application is heated in a surface contact manner, and the heating effect is better. Furthermore, the clamping grooves in the present application are provided with a plurality of different lengths, which can match chromatographs with different lengths, and the applicability is wider.

[0063] Referring to Figure 2 and Figure 3 , the detection box comprises a shell 41, and a lamp source and a detection element arranged inside the shell 41, a detection space 43 is arranged on the first side of the shell, and the detection space 43 is located outside the shell 41.

[0064] Referring to Figures 7-11 , a partition plate 5 is detachably arranged inside the shell 41, the partition plate 5 and the bottom wall of the shell 41 and the side wall of the first side of the shell form a closed heat dissipation space around the lamp source 46, and the heat dissipation space extends along the first side to the third side of the shell; that is, the heat dissipation space is a straight channel, and hot air in the heat dissipation space can be directly discharged from the first end to the second end, and the heat dissipation efficiency is high.

[0065] Referring to Figure 16 , the heat dissipation space is sequentially divided into a cooling area 13, a flow channel 14 and a heat dissipation area 15 from the first end to the second end, at least one side wall of the cooling area 13 is provided with an air inlet 52, the air inlet 52 is provided with a suction device 6, the lamp source 46 is arranged in the cooling area 13 and corresponds to the suction device 6; the heat dissipation area 15 is provided with an air outlet 53 corresponding to the third side of the shell 41, and the air outlet 53 is provided with an exhaust device 7; accordingly, referring to Figure 5 , the shell is respectively provided with at least one air inlet hole 411 corresponding to the suction device and an air outlet hole 412 corresponding to the exhaust device. That is, the air inlet is arranged on the side wall of the shell, and the air outlet is arranged on the back side of the shell, which does not affect the operation of the user; that is, the air inlet and the air outlet are located at two ends of the heat dissipation space, and the heat dissipation space penetrates through the entire inside of the shell.

[0066] In some embodiments, referring to Figure 11 , the partition plate is an n-shaped partition plate, both ends of the n-shaped partition plate are open, a mounting plate 54 is arranged at the opening of the second end of the partition plate, and the exhaust device is arranged on the mounting plate 54. When the partition plate 5 and the mounting plate 54 are installed in the shell 41, the partition plate 5, the mounting plate 54, and the bottom wall and the first side wall of the shell 41 enclose a heat dissipation space.

[0067] In some embodiments, both the air suction device and the exhaust device are fans (preferably silent fans).

[0068] The present application corresponds the lamp source (i.e. heat source) to the cooling area, the cold air sucked by the air suction device is directly blown to the lamp source, which can directly and quickly cool the lamp source, and the hot air generated by the heat exchange of the cold air blown through the lamp source enters the flow channel for buffering, and then is extracted by the exhaust device arranged at the rear side of the detection box. On the one hand, the airflow path is clear, and the heat can be efficiently taken out of the channel, avoiding the accumulation of heat in the channel. Moreover, due to the design of the acceleration section of the channel and the straight and hollow structure of the channel itself, the hot air will not form complex vortex or backflow phenomenon in the channel, thereby ensuring the continuity and effectiveness of heat dissipation.

[0069] In some embodiments, referring to Figure 17 , the inner diameter of the flow channel gradually decreases from the first end to the second end and then increases, so that the flow channel is divided into an aggregation section 141, an acceleration section 142 and a buffer section 143 from the first end to the second end. The inner diameter of the acceleration section 142 is smaller than the inner diameters of the aggregation section 141 and the buffer section 143. The first end of the flow channel is close to the air suction device, and the second end of the flow channel is close to the exhaust device, that is, the inner diameters of the two ends of the flow channel are greater than the inner diameter of the middle part, so that an acceleration section is formed in the middle part of the flow channel. Of course, the inner diameter here can also be the width or length. In short, the cross-sectional area of the channel of the acceleration section is smaller than the cross-sectional area of the channels of the aggregation section and the buffer section.

[0070] In some embodiments, the ratio of the inner diameter of the acceleration section to the inner diameters of the two ends of the flow channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the flow channel gradually shrink inward, so that the cross-sectional area of the middle section (acceleration section) is reduced to 40%-60% (preferably 50%) of the cross-sectional area of the two ends.

[0071] In some embodiments, the inner diameters of the two ends of the flow channel, i.e. the first end of the converging section and the first end of the buffer section, are the same as the inner diameters of the second end of the cooling zone and the first end of the heat dissipation zone, respectively, so that the flow channel smoothly transitions with the cooling zone and the heat dissipation zone, respectively.

[0072] In some embodiments, the accelerating section is divided into multiple sections, and the accelerating section is alternately divided into a narrowing section 1421 and a restoring section 1422, the inner diameter of the narrowing section 1421 is smaller than the inner diameter of the restoring section 1422, so that after the hot air enters the accelerating section (a longer channel), the hot air can avoid the high pressure loss caused by the long channel, thereby ensuring that a continuous negative pressure is formed in the converging section. In some specific embodiments,

[0073] After the cold air enters the cooling zone at the first end of the heat dissipation space and fully exchanges heat with the light source, the hot air is quickly guided to the converging section by the negative pressure formed in the converging section under the accelerating effect of the accelerating section, so as to prevent the mixed hot air after heat exchange from mixing with the cold air newly entering the cooling zone, thereby reducing the heat dissipation effect and ensuring that the air around the light source has a large temperature difference with the light source. Then, the hot air gathered in the converging section enters the accelerating section and is quickly discharged, and then enters the buffer section for temporary storage. On the one hand, the hot air can be prevented from escaping or conducting to the outside from the accelerating section. On the other hand, the hot air can be conveniently discharged by the exhaust device located at the second end of the heat dissipation space. Further, due to the difference in inner diameters of the accelerating section and the buffer section, the hot air at the second end of the heat dissipation space can also be effectively prevented from flowing back to the first end. That is, the present application provides a "quick flow guiding and backflow preventing heat dissipation structure".

[0074] In this paper, the first side 401 (i.e. the front side, the side for user operation) of the shell, the second side 402, the third side 403 (i.e. the back side) and the fourth side 404 can be seen from Figure 6 , specifically, the side provided with the detection space is the first side 401, the side provided with the air inlet is the second side 402, the side provided with the air outlet is the third side 403, and the side close to the detection element is the fourth side 404; that is, the first side 401 and the third side 403 are oppositely arranged, and the second side 402 and the fourth side 404 are oppositely arranged.

[0075] In some embodiments, referring to Figure 9 , the two side edges of the partition plate 5 in contact with the bottom wall of the shell extend to both sides of the heat dissipation space to form a curled edge 51 parallel to the bottom wall, and at least two clamping blocks 44 are arranged on the bottom wall; when the two curled edges 51 are fixed by the at least two clamping blocks 44 respectively, the curled edges 51 are attached to the bottom wall. By arranging the curled edges and the clamping blocks on the bottom wall for clamping and fixing, quick disassembly and assembly can be achieved, and the curled edges attached to the bottom wall can further improve the sealing performance of the heat dissipation space.

[0076] In some embodiments, referring to Figure 11 , the two side edges of the partition plate 5 in contact with the bottom wall of the shell extend to both sides of the heat dissipation space to form a flange parallel to the bottom wall, and at least one through hole is arranged on the flange. Correspondingly, at least one threaded hole corresponding to the through hole is arranged on the bottom wall. When a bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition plate on the bottom wall, and the flange is attached to the bottom wall, that is, the flange is parallel to the bottom wall at this time.

[0077] In some embodiments, referring to Figure 2 , the air inlet is arranged on one of the side walls of the first end of the partition plate, and correspondingly, the air inlet hole 411 is arranged on the second side of the shell 41.

[0078] In some embodiments, referring to Figure 5 , two air inlets are arranged, and the two air inlets are respectively located on the top and one of the side walls of the partition plate; correspondingly, two air inlet holes 411 are also arranged, and the two air inlet holes 411 are respectively located on the top and the second side of the shell.

[0079] In some embodiments, the detection space is formed by inwardly recessing the outer surface of the first side of the shell, and a sample detection area corresponding to the opening and a mounting area for mounting a water guide pipe are arranged in the detection space.

[0080] In some embodiments, the sample detection area is provided with a movable window, and the movable window is in a closed state during detection. A user can overhaul or replace the lamp source located inside the shell by opening the movable window.

[0081] In some embodiments, the partition plate is arranged close to the second side of the shell, and the detection element is arranged close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0082] In some specific embodiments, the detection box is divided into left and right parts, the lamp source and the sample detection area are located in the left half part, and correspondingly, the partition plate is also arranged in the left half part; and the detection element (such as a sensor, a data acquisition and processing unit, a signal amplifier, etc.) and the water guide pipe are arranged in the right half part, preferably at the rightmost end of the detection box, that is, away from the lamp source, so as to separate the lamp source from other elements, and as far as possible to reduce or avoid the heat generated by the lamp source from being conducted to the detection element and the water guide pipe and other components, thereby causing inaccurate measurement results or component aging.

[0083] In some embodiments, referring toFigure 10 and Figure 11 , heat insulation cotton 12 is provided on the partition (preferably the top).

[0084] In some embodiments, see Figure 14 The chromatograph further includes a water guide assembly, which includes a water guide pipe 9 and a water guide column. The water guide column is arranged in the installation area, and the water guide pipe 9 is detachably connected to the water guide column.

[0085] In some embodiments, see Figure 12 and Figure 13 The installation area is provided with a limiting step 433, and the water guide column 8 is provided with a buckle 81. When the buckle 81 is buckled on the limiting step 433, the water guide column 8 is fixed to the housing 41. By providing a detachable external water guide pipe, the water guide pipe can be quickly disassembled and assembled.

[0086] In some embodiments, see Figure 12 The mounting area is provided with a plurality of limiting protrusions 434, which cooperate to form limiting grooves for fixing the water guide column 8. By fixing the pipe body of the water guide column through the limiting grooves, the water guide column can be prevented from swinging in the detection space and causing leakage.

[0087] In some embodiments, see Figure 3 A water channel 10 is provided at the bottom of the detection space. The height of the water channel 10 gradually decreases from its first end to its second end, forming an inclined drainage slope. A waste liquid outflow port 11 is provided at the second end of the water channel 10. The inclined drainage slope ensures that waste liquid generated during the detection process can be quickly discharged.

[0088] In some embodiments, the infusion pump and the column temperature box are both provided with water guide columns and water guide tubes. Their specific structure and installation method can refer to the water guide tubes and water guide columns in the detection box, and will not be repeated here; wherein, the infusion pump, the column temperature box and the water guide tubes on the detection box are connected in sequence.

[0089] In some embodiments, a water guide groove is provided at the bottom of the infusion pump and the column temperature box, and the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and the second end of the water guide groove is provided with a waste liquid outflow outlet.

[0090] In some embodiments, the waste liquid outlet is connected to the water inlet end of the water pipe, that is, the waste liquid outlets on the infusion pump, the column temperature box and the detection box are connected to the water pipes arranged thereon, and the three water pipes are also connected in sequence.

[0091] In some embodiments, referring to Figures 2-4 , the infusion device, the column temperature box and the detection box are each provided with a magnetic door 45;

[0092] Specifically, the infusion device and the first side of the column temperature box are each provided with a mounting space, and a plurality of first magnetic elements 413 are arranged on the mounting space; the infusion device and the column temperature box further comprise a magnetic door 45, and a plurality of second magnetic elements 451 corresponding to the first magnetic elements 413 are arranged on the magnetic door 45; when the magnetic door 45 is mounted on the infusion device and / or the column temperature box through the second magnetic elements 451 and the first magnetic elements 413, the magnetic door 45 and the mounting space enclose a closed space, and the water guide pipe of the infusion device and the column temperature box is located in the closed space.

[0093] A plurality of first magnetic elements 413 are arranged on the detection space; the detection box further comprises a magnetic door 45, and a plurality of second magnetic elements 451 corresponding to the first magnetic elements 413 are arranged on the magnetic door 45; when the magnetic door 45 is mounted on the shell through the second magnetic elements 451 and the first magnetic elements 413, the shell and the magnetic door 45 enclose the closed detection space. That is, the magnetic door 45 blocks the opening of the detection space, so that the detection space is a closed space.

[0094] In some embodiments, the first magnetic elements 413 and the second magnetic elements 451 are both magnets.

[0095] In summary, the present application provides a heat dissipation scheme that limits heat to a limited area and quickly leads heat out through a "straight-flow" convection air duct; specifically, the present scheme sets up a "straight-flow" partitioned isolation heat dissipation channel, synchronously introduces cold air into the heat dissipation space through the air suction device and the air exhaust device, and exhausts hot air from the heat dissipation space, so that the air inside the heat dissipation space is quickly drained from the first end to the second end for exhaust, realizing the rapid concentrated heat dissipation of the light source. On the one hand, a large amount of heat generated by the light source can be concentrated in the heat dissipation space, thereby preventing the heat from spreading to the area where the detection element or the water guide pipe is located to cause adverse effects; on the other hand, the drainage channel can buffer the heat, that is, the heat generated by the light source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessively high temperature of the light source; further, the "straight-flow" air duct design can make the airflow path clear, thereby efficiently leading the heat out of the channel and avoiding the accumulation of heat in the channel.

[0096] Embodiment Two

[0097] This embodiment is basically as shown in Figure 15 , Figures 19-22 ​

[0098] Referring to Figure 15 The embodiment provides a column oven for a liquid chromatograph, which comprises a shell 300, and a heating device and a refrigerating device arranged in the shell 300, a heat-conducting part 301 is arranged on a first side of the shell 300, the heating device is in surface contact with the heat-conducting part 301, a mounting piece 302 in the shape of a trapezoid is arranged on a second surface of the heat-conducting part 301, a plurality of mounting grooves with different lengths are arranged transversely on the mounting piece 302, the mounting grooves are in the shape of an arc in cross section, the mounting grooves penetrate through the mounting piece, and fixing clamps are arranged at two ends of the mounting grooves respectively; when a chromatographic column 303 is fixed on the fixing clamps, a middle part of the chromatographic column 303 is wrapped in the mounting grooves, and two ends of the chromatographic column 303 are suspended outside the mounting grooves.

[0099] By arranging the mounting grooves with different lengths, chromatographic columns with different lengths can be correspondingly arranged, and the mounting grooves are arranged in the shape of a trapezoid (arranged in hierarchical levels), no matter which mounting groove is used to arrange the chromatographic column, at least one side of the mounting groove can reserve sufficient operation space, for example, the end of the second mounting groove from top to bottom, that is, the upper side of the two fixing clamps of the mounting groove is not blocked, thereby facilitating the user to operate.

[0100] Further, the fixing clamps are arranged at the two ends of the mounting grooves, which is easy to replace, and when the chromatographic column is arranged, the user can hold the fixing clamps by the bolts (that is, the parts with larger diameters), and push the chromatographic column into the fixing clamps to be fixed, so that the chromatographic column can be automatically connected with the mounting grooves, and repeated adjustment is not needed.

[0101] In some embodiments, a heat-conducting space is arranged in the shell, the column oven further comprises a heating device and a refrigerating device arranged in the heat-conducting space, one side of the shell is provided with a mounting space for mounting the chromatographic column, and the mounting space corresponds to the heating part.

[0102] In some embodiments, referring to Figure 22 The heating device comprises a plurality of heating pipes 305 arranged in the heat-conducting part 301 or close to the heat-conducting part 301, the number of the heating pipes 305 is the same as the number of the mounting grooves (preferably 4 / one), and the plurality of heating pipes 305 correspond to the plurality of mounting grooves one by one; so that the heat conduction between the heat-conducting pipes and the chromatographic column 303 is more uniform and direct, in other words, the heat of the heat-conducting pipes can be first "directed" to the chromatographic column 303 through the heat-conducting part 301 to realize heating, instead of being conducted to all parts of the heat-conducting panel indiscriminately as in the prior art, so that the purpose of saving heat sources is achieved.

[0103] In some embodiments, the refrigeration device is installed in intermittent contact with the heat-conducting part 301, when the cold end 307 of the refrigeration device is in contact with the heat-conducting part 301, the heat-conducting part 301 can be used to cool the chromatographic column 303, and when the refrigeration device is away from the first surface of the heat-conducting part 301, the refrigeration device no longer cools the chromatographic column 303.

[0104] In some specific embodiments, the refrigeration device comprises a cold end 307, a refrigeration sheet 312, an elastic member 308 and a pull rod motor 309 connected in sequence, wherein the output end of the pull rod motor 309 is connected with the refrigeration sheet 312 through the elastic member 308, the refrigeration sheet 312 is surface-mounted with the cold end 307, and the cold end 307 corresponds to but does not contact the heat-conducting part 301.

[0105] When the output end of the pull rod motor 309 is elongated, the output end of the pull rod motor 309 drives the refrigeration sheet 312 and the cold end 307 to move towards the heat-conducting part 301, so that the cold end 307 tightly contacts the heat-conducting part 301, and the elastic member 308 is compressed, the heat generated by the refrigeration sheet 312 is conducted to the heat-conducting part 301 through the cold end 307, and then to the mounting member and the chromatographic column 303.

[0106] When the output end of the pull rod motor 309 is retracted, the elastic member 308 resets, driving the refrigeration sheet 312 and the cold end 307 to reset, and then the cold end 307 no longer contacts the heat-conducting part 301.

[0107] In this way, during the heating process, the refrigeration device is kept in the closed state, and the heat generated by the heating tube 305 will not be conducted to the refrigeration device to cause heat loss, and only when refrigeration is needed, the cold end 307 is in contact with the heat-conducting part 301 to achieve refrigeration, that is, the refrigeration device and the heating device in the present application are independently arranged and work independently without interference.

[0108] In some embodiments, the refrigeration device further comprises heat sinks 310 arranged on both sides of the refrigeration sheet 312, and correspondingly, the housing is provided with heat dissipation fans 311 corresponding to the heat sinks 310.

[0109] In some embodiments, the heat-conducting part 301 is provided with a temperature sensor 306.

[0110] In some embodiments, the lengths of the mounting grooves increase successively from top to bottom.

[0111] In some embodiments, the mounting member is in the shape of an isosceles trapezoid, and the connecting line of the center points of the mounting grooves is parallel to the height direction of the chromatograph.

[0112] In some embodiments, referring to Figure 21 , the fixing clamp comprises a connecting portion connected with the mounting member, and an upper clamping piece 341 and a lower clamping piece 342 symmetrically arranged on both sides of the connecting portion, the connecting portion, the upper clamping piece 341 and the lower clamping piece 342 form a clamping space 344, the upper clamping piece 341 and the lower clamping piece 342 can be deformed under external force, and the connecting portion cannot be deformed.

[0113] In some embodiments, the upper clamping piece 341 and the lower clamping piece 342 extend outward at one end away from the connecting portion to form a guide space 343 with gradually increasing height;

[0114] When the chromatographic column enters the clamping space 344 along the guide space 343, the upper clamping piece 341 and the lower clamping piece 342 are deformed outward respectively, so that the clamping space 344 becomes larger, and when the chromatographic column completely enters the clamping space 344, the upper clamping piece 341 and the lower clamping piece 342 reset to clamp the chromatographic column.

[0115] In some embodiments, the connecting portion comprises a base body arranged in the vertical direction, the base body gradually contracts inward so that the height of the connecting portion gradually decreases from the first end to the second end, the upper clamping piece and the lower clamping piece are connected with the second end of the connecting portion, the clamping space is circular or elliptical with both sides open, and the diameter of the clamping space is greater than the height of the second end of the connecting portion, and the guide space is horn-shaped with the opening outward (i.e., the opening of the clamping space).

[0116] The present application provides a guide space with a guiding function, so that the user only needs to roughly align the chromatographic column with the clamping space during the process of pushing the chromatographic column into the clamping space, and the chromatographic column can automatically enter the clamping space and be clamped under the guiding action of the guide space.

[0117] In some embodiments, referring to Figure 19 , the column oven further comprises a water guide assembly arranged in the height direction of the column oven, the water guide assembly comprises a water guide column 8 and a flexible water guide pipe 9, a first end of the water guide column 8 is provided with a water guide cavity, a bottom of the water guide cavity is opened and extends downward to form a water guide channel penetrating through the water guide column, and a first end of the water guide pipe is detachably connected with a second end of the water guide column, so that the water guide pipe communicates with the water guide channel.

[0118] In some embodiments, a water guide groove is arranged on the detection box and communicates with the water guide cavity, so that the waste liquid generated in the detection box can be drained into the water guide cavity through the water guide groove, and then flows out through the water guide channel and the water guide pipe.

[0119] The external water guide pipe is detachably arranged, and the water guide pipe can be quickly disassembled and assembled.

[0120] In summary, the application provides a layered fixed-point heating column oven with face contact, which can meet the installation and heating needs of chromatographic columns of different lengths, is simple and convenient to use, and has high heating efficiency.

[0121] Embodiment three

[0122] This embodiment is basically as shown in Figures 12-14 and Figure 19 :

[0123] The application provides a liquid drainage system for a liquid chromatograph, wherein the chromatograph comprises a tray, a liquid delivery device, a column oven and a detection box arranged in sequence from top to bottom, and the specific structure of the chromatograph can refer to the chromatograph structure in Embodiment One.

[0124] The liquid drainage system comprises three water guide assemblies connected in sequence along the height direction of the chromatograph, and the three water guide assemblies are arranged on the liquid delivery device, the column oven and the detection box, respectively.

[0125] Specifically, the water guide assembly comprises a water guide column 8 and a flexible water guide pipe 9 (for example, a rubber hose), the first end of the water guide column 8 is provided with a water guide cavity 82, the bottom of the water guide cavity 82 is provided with an opening and extends downward to form a water guide channel 83 penetrating through the water guide column 8, and the first end of the water guide pipe 9 is detachably connected with the second end of the water guide column 8, so that the water guide pipe 9 and the water guide channel 83 are in communication.

[0126] The three water guide columns 8 are fixed (including a detachable fixing mode) on the liquid delivery device, the column oven and the detection box, respectively, the second end of the water guide pipe 9 on the liquid delivery device is in butt joint with the water guide cavity 82 on the column oven, and the second end of the water guide pipe 9 on the column oven is in butt joint with the water guide cavity 82 on the detection box. That is to say, the water guide pipe 9 and the water guide column 8 of the same water guide assembly are detachably connected and internally communicated to form a waste liquid channel, and the adjacent water guide assemblies are in communication with each other, so that the water guide assemblies on the liquid delivery device, the column oven and the detection box are in sequence communication to form a complete liquid drainage system.

[0127] In some embodiments, the liquid delivery device, the column oven and the detection box are respectively provided with a water guide groove in communication with the water guide cavity 82, so that the waste liquid generated in the liquid delivery device, the column oven and the detection box can be drained into the water guide cavity 82 through the water guide groove and then flow out through the water guide channel 83 and the water guide pipe 9.

[0128] In some embodiments, the diameter of the water guide cavity 82 is larger than the diameter of the pipe, and when the second end of the pipe is connected to the water guide cavity 82, there is still some space between the water guide cavity 82 and the pipe, which facilitates the waste liquid in the water guide groove to enter the water guide cavity 82.

[0129] In some embodiments, the height of the water guide groove gradually decreases from the first end to the second end to form an inclined slope, and the second end of the water guide groove is in communication with the water guide cavity 82.

[0130] In some embodiments, the infusion device, the column temperature box and the detection box are respectively provided with a recess 436 for accommodating the water guide cavity 82, and the bottom of the recess 436 is provided with a limiting step 433; the water guide cavity 82 is located in the recess 436, the bottom of the water guide cavity 82 abuts against the limiting step 433, and the second end of the water guide column 8 extends out of the recess 436 and is located below the recess 436.

[0131] In some embodiments, the bottom of the water guide column 8 is provided with a buckle 81, and the buckle 81 and the bottom of the water guide groove form a clamping groove, and the limiting step 433 is located in the clamping groove. That is, the water guide column 8 can be fixed in the water guide groove by clamping, and at this time, the clamping groove can limit the water guide column 8 in the vertical direction, and the water guide groove can limit the water guide column 8 in the horizontal direction.

[0132] In some embodiments, the infusion device, the column temperature box and the detection box are respectively provided with at least two limiting protrusions 434, and the two limiting protrusions 434 cooperatively form a limiting groove for limiting the water guide pipe 9 in the horizontal direction. When the water guide pipe 9 is installed in the limiting groove, the two limiting protrusions 434 are respectively located on both sides of the water guide pipe 9 to prevent the water guide pipe 9 from moving horizontally.

[0133] In some embodiments, the bottom of the water guide cavity 82 extends downward to form a transition section 84 and a connecting section 85 in sequence; the diameter of the transition section 84 is larger than the diameter of the connecting section 85, and the water guide pipe 9 is sleeved on the connecting section 85. By providing the transition section 84, the stability of the water guide column 8 can be improved.

[0134] In some embodiments, the infusion device, the column temperature box and the detection box are respectively provided with a limiting hole, and the limiting hole is located below the recess 436, and the second end of the water guide column 8 extends out of the limiting hole and is located below the limiting hole. By providing the limiting hole, the water guide column 8 can be limited in different heights to further prevent the water guide column 8 from swinging horizontally.

[0135] In some embodiments, the at least two limiting protrusions 434 are staggered along the height direction of the liquid chromatograph and are respectively located on both sides of the water guide pipe 9, so that both sides of the water guide pipe 9 form a slot 435. For example, two limiting protrusions 434 are respectively arranged on both sides of the water guide pipe 9, the limiting protrusions 434 located on one side form a first slot 435, the limiting protrusions 434 located on the opposite side form a second slot 435, the heights of the first slot 435 and the second slot 435 are different, that is, the limiting protrusions 434 on both sides are staggered, and the two slots 435 are also staggered, which facilitates the user to hold at least one side of the water guide pipe 9 from the slot part and take out the water guide pipe 9 from the limiting slot.

[0136] In some embodiments, the second end of the connecting section 85 extends downward and the outer diameter gradually decreases to form a guide slope. This facilitates the insertion of the water guide pipe 9 into the second end of the water guide column 8 along the guide slope.

[0137] In summary, the present application provides an external split liquid drainage pipeline design with multiple limiting structures. Specifically, the water guide pipe is connected to the water guide column in a single-sided fixed manner and is limited by multiple limiting structures. This ensures the stability of the liquid drainage system and facilitates the quick disassembly and assembly of the water guide pipe.

[0138] Firstly, the water guide column in the present liquid drainage system is fixed on the chromatograph, one end of the water guide pipe is sleeved on one end of the water guide column, and the other end is connected to the water guide cavity but is not fixed. That is, the water guide pipe is installed in a single-sided fixed manner. On the one hand, it is convenient to replace the water guide pipe, and on the other hand, the water guide column is fixed on the chromatograph, so that the water guide pipe can be automatically aligned through the water guide column after replacing the water guide pipe.

[0139] Further, multiple limiting structures are arranged on the chromatograph, for example, a limiting step and a limiting hole are matched to limit the water guide column in the transverse direction, and a limiting slot is arranged to limit the water guide pipe in the transverse direction. This ensures that the water guide column and the water guide pipe always maintain a corresponding state, thereby ensuring the stability of the liquid drainage system.

[0140] Further, by arranging an inclined drainage slope, the waste liquid generated during the detection process can be ensured to flow into the open water guide cavity and be quickly discharged.

[0141] Embodiment Four

[0142] In the prior art, the heat dissipation mode of the chromatograph is to set an air extraction device on the side wall of the detection box to extract the hot air distributed in the detection box, thereby achieving the purpose of heat dissipation. For example, the Chinese utility model patent with the application number 202120699737.2 discloses an ion chromatograph. In the ion chromatograph, the light source (usually refers to deuterium lamp and tungsten lamp, i.e. heat source) is exposed to the entire cavity of the detection box. A large amount of heat generated by the light source is quickly distributed to the entire cavity. In the case of low ambient temperature such as cold storage, even if the heat is distributed to the cavity, the heat in the cavity exchanges heat with the cold air in the environment, and the air extraction device arranged on the side wall of the detection box can basically achieve the cooling of the cavity. However, this method at least has the following defects: for example, the heat generated by the light source is distributed to the entire cavity of the detection box without distinction. After the detection element in the cavity is heated, it is extremely likely to cause inaccurate measurement results. For another example, if some elements in the detection box (such as the water guide pipe located in the detection cavity) are exposed to a high-temperature environment for a long time, the aging of the elements will be accelerated.

[0143] In addition, if the ambient temperature is high (for example, in a general laboratory, especially in the case of summer power rationing, the air conditioner temperature cannot be adjusted too low, at this time the indoor temperature is about 20-25°), at this time if a large amount of heat is stored in the cavity, the heat exchange speed between the heat in the cavity and the air in the environment is slow, and the air extraction device arranged on the side wall of the detection box is difficult to achieve rapid cooling of the cavity.

[0144] Based on the above background, the present embodiment provides a detection box of a liquid chromatograph, as shown in Figure 1 and Figure 10 The detection box comprises a shell 41, and a light source 46 and a detection element 42 arranged inside the shell 41.

[0145] Further comprising a partition plate 12 detachably arranged inside the shell 41, the partition plate 12 and the bottom wall of the shell 41 and the side wall of the first side of the shell 41 form a closed heat dissipation space around the light source 46, and the heat dissipation space extends along the first side to the third side of the shell. That is, the heat dissipation space is a straight channel, and the hot air in the heat dissipation space can be directly discharged from the first end to the second end, and the heat dissipation efficiency is high.

[0146] Referring to Figure 16, the heat dissipation space is divided into a cooling area 13, a flow channel 14 and a heat dissipation area 15 from the first end to the second end in sequence, at least one side wall of the cooling area 13 is provided with an air inlet 52, the air inlet 52 is provided with a suction device 6, the light source 46 is arranged in the cooling area 13 and corresponds to the suction device 6; the heat dissipation area 15 is provided with an air outlet 53 corresponding to the third side of the shell 41, and the air outlet 53 is provided with an exhaust device 7; accordingly, referring to Figure 5 , the shell is respectively provided with at least one air inlet hole 411 corresponding to the suction device and an air outlet hole 412 corresponding to the exhaust device. That is, the air inlet is arranged on the side wall of the shell, and the air outlet is arranged on the back side of the shell, which does not affect the operation of the user; that is, the air inlet and the air outlet are located at two ends of the heat dissipation space, and the heat dissipation space penetrates through the entire shell inside.

[0147] In some embodiments, the air inlet is provided with two air inlets, and the two air inlets are respectively located at the top and the second side of the partition plate.

[0148] In some embodiments, referring to Figure 11 , the partition plate is an n-shaped partition plate, both ends of the n-shaped partition plate are open, the mounting plate 54 is arranged at the opening of the second end of the partition plate, and the exhaust device is arranged on the mounting plate 54; when the partition plate 5 and the mounting plate 54 are installed in the shell 41, the partition plate 5, the mounting plate 54 and the bottom wall and the first side wall of the shell 41 form a heat dissipation space.

[0149] In some embodiments, the suction device and the exhaust device are both fans (preferably silent fans).

[0150] In the application, the light source (i.e. heat source) corresponds to the cooling area, the cold air sucked by the suction device is directly blown to the light source, which can directly and quickly cool the light source, and the hot air generated by the heat exchange of the cold air blown through the light source enters the flow channel for buffering, and then is extracted by the exhaust device arranged at the back side of the detection box. On the one hand, the airflow path is clear, and the heat can be efficiently taken out of the channel, avoiding the accumulation of heat in the channel; and due to the design of the acceleration section of the channel and the straight and hollow structure of the channel itself, the hot air does not form complex vortex or backflow phenomenon in the channel, thereby ensuring the continuity and effectiveness of heat dissipation.

[0151] In some embodiments, referring to Figure 17, the inner diameter of the first end to the second end of the flow channel gradually decreases and then increases, so that the flow channel is divided into the gathering section 141, the accelerating section 142 and the buffering section 143 from the first end to the second end, and the inner diameter of the accelerating section 142 is smaller than the inner diameters of the gathering section 141 and the buffering section 143. Wherein, the first end of the flow channel is close to the air suction device, and the second end of the flow channel is close to the air exhaust device, that is, the inner diameters of the two ends of the flow channel are larger than the inner diameter of the middle part, so that the accelerating section is formed in the middle part of the flow channel. Of course, the inner diameter here can also be the width or length, in general, the cross-sectional area of the channel of the accelerating section is smaller than the cross-sectional areas of the channels of the gathering section and the buffering section.

[0152] In other words, in some embodiments, the inner diameter of the gathering section gradually decreases from the first end to the second end, and the inner diameter of the buffering section gradually increases from the first end to the second end, so that the flow channel is similar to an X shape. That is, the diameter of the middle part of the flow channel is small, and the two ends respectively extend to the two sides and the inner diameter gradually increases, and the flow channel is similar to an X shape, but not completely in the shape of an X, and the middle part is not closed, and the gathering section and the buffering section can be in the shape of a slope or an arc. Of course, the inner diameter here can also be the width or length, in general, the cross-sectional area of the channel of the accelerating section is smaller than the cross-sectional areas of the channels of the gathering section and the buffering section. Wherein, the first end of the flow channel is close to the air suction device, and the second end of the flow channel is close to the air exhaust device.

[0153] In some embodiments, the ratio of the inner diameter of the accelerating section to the inner diameters of the two ends of the flow channel is 0.4-0.6 (preferably 0.5), that is, the two ends of the flow channel gradually shrink inward, so that the cross-sectional area of the middle section (the accelerating section) is reduced to 40%-60% (preferably 50%) of the cross-sectional areas of the two ends.

[0154] In some embodiments, the inner diameters of the two ends of the flow channel, that is, the first end of the gathering section and the first end of the buffering section, are the same as the inner diameters of the second end of the cooling area and the first end of the heat dissipation area, respectively, so that the flow channel is smoothly connected with the cooling area and the heat dissipation area, respectively.

[0155] In some embodiments, the accelerating section is divided into multiple sections, and the sections are alternately used as the reducing section 1421 and the restoring section 1422, and the inner diameter of the reducing section 1421 is smaller than the inner diameter of the restoring section 1422, so that after the hot air enters the accelerating section (a longer channel), the high pressure loss caused by the long channel can be avoided, thereby ensuring that a continuous negative pressure is formed in the gathering section.

[0156] In some specific embodiments, the cold air enters the cooling area at the first end of the heat dissipation space, and after fully exchanging heat with the light source, the hot air is quickly introduced to the gathering section by the negative pressure formed by the acceleration of the acceleration section, so as to prevent the mixed hot air from mixing with the cold air entering the cooling area, thereby reducing the heat dissipation effect, ensuring that the air around the light source has a large temperature difference with the light source, and then the hot air gathered in the gathering section enters the acceleration section and is quickly discharged from the buffer section. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the outside, and on the other hand, it can facilitate the exhaust device at the second end of the heat dissipation space to discharge the hot air. Further, due to the difference in the inner diameter of the acceleration section and the buffer section, the hot air at the second end of the heat dissipation space can also be effectively prevented from flowing back to the first end. That is, the present application provides a "quick drainage anti-backflow heat dissipation structure".

[0157] In some embodiments, the partition plate is arranged close to the second side of the shell, and the detection element is arranged close to the fourth side of the shell, so that an isolation space is formed between the detection element and the heat dissipation space.

[0158] In some specific embodiments, the detection box is divided into left and right two parts, the light source and the sample detection area are located in the left half part, and the partition plate is also arranged in the left half part. The detection element (such as sensor, data acquisition and processing unit, signal amplifier, etc.) and the water guide pipe are arranged in the right half part, preferably at the rightmost end of the detection box, that is, away from the end of the light source, so as to separate the light source from other elements, and as far as possible to reduce or avoid the heat generated by the light source to conduct to the detection element and the water guide pipe and other components, resulting in inaccurate measurement results or component aging problems.

[0159] In some embodiments, referring to Figure 9 The two side edges of the partition plate 5 in contact with the bottom wall of the shell extend to both sides of the heat dissipation space to form a curled edge 51 parallel to the bottom wall, and at least two clamping blocks 44 are arranged on the bottom wall. When the two curled edges 51 are fixed by the at least two clamping blocks 44 respectively, the curled edges 51 are attached to the bottom wall. By arranging the curled edges and the clamping blocks on the bottom wall for clamping and fixing, the curled edges are attached to the bottom wall, which can further improve the sealing performance of the heat dissipation space while achieving quick disassembly.

[0160] In other embodiments, referring to Figure 11The two side edges of the partition plate 5 in contact with the bottom wall of the shell extend to both sides of the heat dissipation space respectively to form a hem parallel to the bottom wall, and at least one through hole is arranged on the hem. Correspondingly, at least one threaded hole corresponding to the through hole is arranged on the bottom wall. When a bolt is passed through the through hole and screwed into the threaded hole, the bolt fixes the partition plate on the bottom wall, and the hem is attached to the bottom wall, that is, the hem is parallel to the bottom wall at this time.

[0161] In some embodiments, the first end of the partition plate is provided with an opening corresponding to the first side of the shell.

[0162] The shell is externally provided with a detection space located at the first side of the shell, and the detection space comprises a sample detection area and a mounting area. The sample detection area is provided with an inspection window corresponding to the opening, and the mounting area is detachably provided with a water guide pipe.

[0163] In some embodiments, a plurality of first magnetic elements are arranged on the shell, and the detection box further comprises a magnetic attraction door provided with a plurality of second magnetic elements corresponding to the first magnetic elements.

[0164] When the magnetic attraction door is installed on the shell through the second magnetic elements and the first magnetic elements, the shell and the magnetic attraction door enclose the sealed detection space. Compared with the traditional hinged door, the magnetic attraction door can greatly improve the sealing performance of the detection space.

[0165] In summary, the present application provides a fixed-point heat dissipation scheme that limits a large amount of heat generated by a lamp source to a limited area and quickly leads the heat out through a set guide path, that is, a "direct current type" convection air duct.

[0166] Specifically, the present scheme synchronously introduces cold air into the heat dissipation space and exhausts hot air from the heat dissipation space by arranging a heat dissipation space extending along the first side to the third side of the shell, cooperating with an air suction device and an air exhaust device respectively located at both sides of the heat dissipation space, so that the air in the heat dissipation space is quickly drained from the first end to the second end for discharge, thereby realizing the rapid concentrated heat dissipation of the lamp source. On the one hand, a large amount of heat generated by the lamp source can be concentrated in the heat dissipation space, thereby preventing the heat from spreading outside the heat dissipation space and adversely affecting the detection elements in the shell or the area where the water guide pipe is located on the shell. On the other hand, the drainage channel can buffer the heat, that is, the heat generated by the lamp source can be quickly dispersed into the drainage channel, thereby preventing the problem of excessively high temperature of the lamp source. The "direct current type" air duct design can make the air flow path clear, thereby efficiently leading the heat out of the channel and avoiding the accumulation of heat in the channel.

[0167] Further, based on the case that the drainage channel is long (i.e. penetrates through the whole shell), the present application divides the drainage channel into multiple functional zones with different inner diameters. During the working process of the chromatograph, the cold air enters the cooling zone at the first end of the heat dissipation space, and fully exchanges heat with the light source. The acceleration of the acceleration section causes the negative pressure of the gathering section, and then the hot air is quickly guided to the gathering section for gathering, so as to prevent the mixed hot air after heat exchange and the cold air newly entering the cooling zone, reduce the heat dissipation effect, and ensure that the air around the light source has a large temperature difference with the light source. Then the hot air gathered in the gathering section is quickly discharged to the buffer section, and then discharged under the action of the exhaust device. On the one hand, it can reduce the escape or conduction of hot air from the acceleration section to the cavity (i.e. other areas outside the heat dissipation space in the shell), and on the other hand, it can facilitate the exhaust device at the second end of the heat dissipation space to discharge the hot air. Further, due to the effect of the difference in inner diameters of the acceleration section and the buffer section, the hot air at the second end of the heat dissipation space can also be effectively prevented from flowing back to the first end. That is, the present application also provides a "quick drainage anti-backflow heat dissipation structure".

[0168] It should be noted that in this document, the terms "comprise", "comprise", or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or other elements inherent to such a process, method, article or device. Without more limitations, the element defined by the statement "comprises a" does not exclude the presence of another identical element in the process, method, article or device including the element.

[0169] The embodiments of the present application are described above in conjunction with the drawings, but the present application is not limited to the above specific embodiments, and the above specific embodiments are only illustrative, not limiting. Those skilled in the art can make many forms under the inspiration of the present application without departing from the purpose of the present application and the scope protected by the claims, and these are all within the protection of the present application.

Claims

1. A liquid chromatograph, characterized in that The apparatus comprises a tray, an infusion set, a column temperature box, and a detection box arranged in order from top to bottom; the detection box comprises a shell, and a light source and a detection element arranged inside the shell, a detection space is provided on a first side of the shell, and the detection space is located outside the shell; A partition is detachably provided inside the housing, and a closed heat dissipation space surrounding the lamp source is formed between the partition, the bottom wall of the housing, and the side wall of the first side of the housing, and the heat dissipation space extends from the first side to the third side of the housing; The heat dissipation space is divided into a cooling zone, a drainage channel, and a heat dissipation zone in sequence from the first end to the second end thereof; an air inlet is provided on at least one side wall of the cooling zone, an air suction device is provided at the air inlet, and the light source is provided in the cooling zone corresponding to the air suction device; the heat dissipation zone is provided with an air outlet corresponding to the third side of the shell, and an exhaust device is provided at the air outlet; accordingly, the shell is respectively provided with at least one air inlet corresponding to the air suction device, and an exhaust hole corresponding to the exhaust device; The drainage channel is divided into a gathering section, an acceleration section, and a buffer section from the first end to the second end thereof, and the inner diameter of the acceleration section is smaller than the inner diameters of the gathering section and the buffer section; The partition is arranged close to the second side of the housing, and the detection element is arranged close to the fourth side of the housing, so that an isolation space is formed between the detection element and the heat dissipation space; The two side edges of the partition contacting the bottom wall of the shell extend toward both sides of the heat dissipation space to form curling edges parallel to the bottom wall, and at least two clamping blocks are provided on the bottom wall; When the two curling edges are fixed respectively by the at least two clamping blocks, the curling edges are attached to the bottom wall.

2. A liquid chromatograph according to claim 1, characterized in that, There are two air inlets, which are respectively located on the top of the partition and one of the side walls.

3. A liquid chromatograph according to claim 1, characterized in that, The partition is an N-shaped partition with openings at both ends. The detection space is formed by the outer surface of the first side of the shell being recessed inward. The detection space is provided with a sample detection area corresponding to the opening and an installation area for installing a water pipe.

4. A liquid chromatograph according to claim 3, characterized in that, The chromatograph further includes a water guide assembly, which includes a water guide pipe and a water guide column. The water guide column is arranged in the installation area, and the water guide pipe and the water guide column are detachably connected.

5. A liquid chromatograph according to any one of claims 1 to 4, characterized in that: The detection space is provided with a plurality of first magnetic elements; the detection box further comprises a magnetic door, and the magnetic door is provided with a plurality of second magnetic elements corresponding to the first magnetic elements; When the magnetic door is mounted on the housing through the second magnetic element and the first magnetic element, the housing and the magnetic door enclose the closed detection space.

6. A liquid chromatograph according to claim 1, characterized in that, A water guide groove is provided at the bottom of the detection space. The height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope. The second end of the water guide groove is provided with a waste liquid outflow outlet.

7. A liquid chromatograph according to claim 1, characterized in that, The bottom of the infusion pump and the column temperature box are both provided with a water guide groove, and the height of the water guide groove gradually decreases from the first end to the second end, so that the water guide groove forms an inclined drainage slope, and the second end of the water guide groove is provided with a waste liquid outflow outlet.

Images