A fungicidal composition comprising diacetylmethoxyfenozide and cyazofamid and its application.

Abstract

This invention belongs to the field of pesticide formulations, specifically relating to a fungicidal composition comprising diyzoxystrobin and cyazofamid and its application; comprising the following components in weight percentage: diyzoxystrobin 5-15%, cyazofamid 5-15%, Tersperse 2510 1-4%, Morwet D-390 1-4%, Agrlian-755 1-4%, magnesium aluminum silicate 0.5-1.5%, organobentonite 0.2-0.8%, propylene glycol 2-6%, sodium chloride 0.5-1.5%, SAG 1522 0.1-0.3%, and deionized water to make up to 100%. The suspension prepared by this invention has excellent formulation properties and excellent control effect on potato late blight.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of pesticide preparation, and particularly relates to a fungicidal composition containing crymycuv and cyazofamid and application thereof. BACKGROUND

[0002] Crymycuv is an amide fungicide, and has good effects on most leaf and fruit diseases caused by Oomycetes. Crymycuv has high activity on spores in the germination stage, and can inhibit mycelium growth and spore formation. Crymycuv can be rapidly absorbed by leaves, and stays in the leaf wax layer to protect the leaves.

[0003] Cyazofamid is a mitochondrial respiration inhibitor, and its fungicide preparation can inhibit cytochrome in the metabolic process of pathogens to cause the death of the pathogens. Cyazofamid has effects on all growth stages of Oomycetes, and has good protective activity and certain systemic curative activity, and has a long effective period.

[0004] Patent document CN201010535147.2 discloses a fungicide composition with synergistic effect, and the effective active ingredients contain crymycuv and cyazofamid. The weight ratio of crymycuv to cyazofamid is 1-85:85-1. The effective active ingredients are added into adjuvants and excipients to form wettable powder, water dispersible granule and suspension concentrate. The composition has high biological activity on Oomycetes such as Pythium, Peronospora, Pseudoperonospora, Saprolegnia and Plasmodiophora brassicae of the Plasmodiophoromycetes class, but the patent document does not study the dosage form of the composition.

[0005] Suspension concentrate is a flowable suspension formed by mixing pesticide raw materials, carriers and dispersants by wet method and ultrafine grinding. It is a stable liquid-solid system with high suspension and flowability, which is formed by uniformly dispersing solid raw materials that are insoluble or slightly soluble in water in water by ultrafine grinding. The suspension concentrate is generally composed of effective components, dispersants, thickening agents, anti-settling agents, defoaming agents, antifreeze agents and water. The content of the effective components is generally 5%-50%, and the average particle size is generally about 3 microns. The suspension concentrate is one of the most important pesticide dosage forms in modern pesticides, and is one of the four environmentally friendly dosage forms recommended by the Food and Agriculture Organization (FAO) of the United Nations.

[0006] There is no related research report on the preparation of suspension concentrate by compounding crymycuv and cyazofamid or cyazofamid in the existing documents. The present application successfully develops the suspension concentrate by screening various adjuvant components in the suspension concentrate, and tests the prevention and treatment effect of the suspension concentrate on potato late blight. SUMMARY

[0007] The present application provides a fungicidal composition containing crymycuv and application thereof, and the specific technical solutions are as follows.

[0008] A fungicidal composition comprising pydiflumetofen, comprising ingredients in the following weight percentage: pydiflumetofen 5-15%, cyazofamid 5-15%, Tersperse 2510 1-4%, Morwet D-390 1-4%, Agrlian-755 1-4%, magnesium aluminum silicate 0.5-1.5%, organic bentonite 0.2-0.8%, propylene glycol 2-6%, sodium chloride 0.5-1.5%, SAG 1522 0.1-0.3%, and deionized water to make up 100%.

[0009] Preferably, the fungicidal composition comprises ingredients in the following weight percentage: pydiflumetofen 8-12%, cyazofamid 8-12%, Tersperse 2510 1-4%, Morwet D-390 1-4%, Agrlian-755 1-4%, magnesium aluminum silicate 0.5-1.5%, organic bentonite 0.2-0.8%, propylene glycol 2-6%, sodium chloride 0.5-1.5%, SAG 1522 0.1-0.3%, and deionized water to make up 100%.

[0010] Preferably, the fungicidal composition comprises ingredients in the following weight percentage: pydiflumetofen 10%, cyazofamid 10%, Tersperse 2510 2%, Morwet D-390 2%, Agrlian-755 3%, magnesium aluminum silicate 1%, organic bentonite 0.5%, propylene glycol 4%, sodium chloride 1%, SAG 1522 0.2%, and deionized water to make up 100%.

[0011] The use of the fungicidal composition of the present application for preventing and treating crop diseases, preferably potato late blight.

[0012] Compared with the prior art, the present application has the following beneficial effects:

[0013] The suspension rate of the suspension concentrate prepared by selecting the wetting dispersant combination Tersperse 2510+Morwet D-390+Agrlian-755 is the highest, and the hot storage stability is excellent; the pouring property and the hot storage stability of the suspension concentrate prepared by selecting the thickening agent combination magnesium aluminum silicate+organic bentonite are the best; the low-temperature stability and the hot storage stability of the suspension concentrate prepared by using propylene glycol+sodium chloride as the antifreezing agent are both excellent.

[0014] The suspension concentrate prepared by the present application can significantly improve the field control effect of the pesticide while reducing the amount of pesticide used. DETAILED DESCRIPTION

[0015] The present application can be better understood according to the following examples. However, those skilled in the art will readily understand that the content described in the examples is only used to illustrate the present application, and should not and will not limit the present application described in detail in the claims.

[0016] Example 1: Preparation of the suspension concentrate of dual fungicide and cyazofamid

[0017] Materials and methods:

[0018] Drugs: dual fungicide, cyazofamid, Tersperse 2510, Morwet D-390, Agrlian-755, Atlox 4913, Atplus 1209, Dispersol BB4, SP-SC29, Morwet D-425; all of the above materials can be purchased from the market.

[0019] Instruments: dispersion sand mill; high performance liquid chromatography; pH meter; BT-9300ST laser particle size distribution instrument; multifunctional circulating constant temperature water bath; heating type magnetic stirrer; electronic analytical balance;

[0020] Preparation method of the suspension concentrate: add the raw drug, wetting dispersant, defoaming agent into the sand mill, add 70% water, shear and disperse for 15 min, then add grinding medium zirconium beads for grinding. After grinding for about 3 h, add thickening agent, antifreezing agent, preservative and the remaining water for conditioning, to obtain a white suspension liquid. According to the preparation method of the suspension concentrate, the formulation of different components is screened, and the prepared suspension concentrate is analyzed and detected for various indexes to determine the best formulation.

[0021] Selection of wetting dispersant

[0022] Due to its own characteristics, the suspension concentrate is prone to physical instability such as delamination and caking during long-term storage, which affects the quality and use effect of the product. The physical stability of the suspension concentrate is key to the selection of wetting dispersant. According to the physicochemical properties of the raw drug, different combinations of wetting dispersants are selected for compatibility test at room temperature, and the best combination of adjuvants is determined by detecting the suspension rate and thermal storage stability of different formulations.

[0023] As shown in Table 1: the suspension rate of the prepared suspension concentrate is the highest and the thermal storage stability is the best when the wetting dispersant combination Tersperse 2510 + Morwet D-390 + Agrlian-755 is selected, and the amount of each component is 2%.

[0024] Table 1: Selection of wetting dispersant

[0025]

[0026] Selection of thickening agent

[0027] The viscosity of the suspension concentrate is an important factor affecting the stability of the suspension concentrate. The rheological properties and flowability of the suspension concentrate liquid can be adjusted by adding a thickening agent to prevent the separation and precipitation of the dispersed particles due to the action of gravity or the dehydration shrinkage effect. Based on the screening results of the wetting dispersant, the thickening agent is combined and screened. The long-term storage stability, flowability, and viscosity range of 200-400 mPa·s (20°C) of the suspension concentrate are used as indicators for screening.

[0028] As shown in Table 2, the selected thickening agent combination of 1% magnesium aluminum silicate + 0.5% organic bentonite has the best pouring property and thermal storage stability of the suspension concentrate.

[0029] Table 2 Screening of thickening agents

[0030]

[0031] Selection of antifreeze

[0032] The antifreeze can improve the stability of the suspension concentrate in a low-temperature environment, and avoid freezing during low-temperature storage and use, which affects the product quality. Based on the screening results of the wetting dispersant and the thickening agent, the optimal antifreeze is determined by detecting the low-temperature stability and thermal storage stability of the suspension concentrate.

[0033] When glycerol is used as an antifreeze, the product shows a stratification phenomenon during low-temperature storage. When 4% propylene glycol + 1% sodium chloride is used as an antifreeze, the low-temperature stability and thermal storage stability of the suspension concentrate are both optimal.

[0034] Table 3 Screening of antifreezes

[0035]

[0036] Preferred formula: Through the screening of wetting dispersants, thickening agents, and antifreezes, the preferred formula of 20% dual acifluorfen·cyazofamid suspension concentrate is finally determined: containing the following ingredients with a weight percentage content: acifluorfen 10%, cyazofamid 10%, Tersperse 2510 2%, Morwet D-390 2%, Agrlian-755 3%, magnesium aluminum silicate 1%, organic bentonite 0.5%, propylene glycol 4%, sodium chloride 1%, SAG 1522 0.2%, and deionized water to 100%.

[0037] The performance indicators of the preparation are shown in Table 4.

[0038] Table 4 Determination of technical indicators of the preparation

[0039]

[0040] Example 2: Test of the control effect of acifluorfen and cyazofamid or cyazofamid suspension concentrate on potato late blight

[0041] Test object: potato late blight

[0042] Test agent:

[0043] Agent 1: 20% of the Spirodiclofen·Chlorothalonil suspension agent in Example 1;

[0044] Agent 2: 40% of the Spirodiclofen·Chlorothalonil suspension agent: Spirodiclofen 20%, chlorothalonil 20%, fatty alcohol polyoxyethylene ether 5%, sodium polyacrylate 2%, sodium dodecylbenzenesulfonate 4%, silicone oil 0.1%, polyvinyl alcohol 0.3%, phenyl phenol polyoxyethylene ether 2%, and deionized water to 100%, mixed to prepare 40% of the Spirodiclofen·Chlorothalonil suspension agent (Example 7 in CN201010535147.2).

[0045] Test method: Start spraying before the onset of late blight in the field (before the first diseased leaves appear), each treatment is mixed with 450 kg of water per hectare, and sprayed uniformly with a small electric sprayer, spraying once every 7 days, a total of 2 times; 14 days after the second spraying, the disease is evaluated. By random sampling, 5 points are selected in each plot, 3 plants are selected in each point, a total of 15 plants, all leaf disease levels are investigated from top to bottom, and the disease index and control effect are calculated according to the disease grade.

[0046] Classification standard of potato late blight;

[0047] 0 represents no disease spot;

[0048] 1 represents that the proportion of the disease spot area in the whole leaf area should be less than 5%;

[0049] 3 represents that the proportion of the disease spot area should be between 6% and 10%;

[0050] 5 represents that the proportion of the disease spot area in the whole leaf is between 11% and 20%;

[0051] 7 represents that the disease spot area occupies 21% to 50% of the whole leaf;

[0052] 9 represents that the disease spot covers more than 50% of the whole leaf area.

[0053] Disease index = ∑(number of plants at each level x representative value) / total number of plants investigated x representative value of the most severe level x 100

[0054] Control effect = (disease index of the control area - disease index of the treatment area) / disease index of the control area x 100

[0055] Test results: Compared with the existing suspension agent, the 20% Spirodiclofen·Chlorothalonil suspension agent prepared by the present application can significantly improve the field control effect on potato late blight.

[0056] Table 5. Test of the efficacy of dual fungicides dimetachlone and cyazofamid or cyazofamid flowable concentrate against potato late blight

[0057]

[0058] The above only is the preferred embodiment of the present application, for those skilled in the art, without departing from the raw material of the present application, can make appropriate improvements, these improvements are also within the scope of the present application.

Claims

1. A fungicidal composition comprising dualiyne acibenzolar-S-methyl and cyazofamid, characterized in that, Comprising ingredients in the following weight percent amounts: mandipropamid 10%, cyazofamid 10%, Tersperse 2510 2%, Morwet D-39 2%, Agrilan-75 53%, Veegum 1%, organobentonite 0.5%, propylene glycol 4%, sodium chloride 1%, SAG 1522 0.2%, deionized water q.s. 100%.

2. Use of the fungicidal composition according to claim 1 for controlling crop diseases, characterized in that, The disease is potato late blight.

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