A dual drug-loaded negative poisson's ratio fabric dressing and a method of making the same

Abstract

The application relates to a double-drug-loaded negative Poisson ratio fabric dressing and a preparation method thereof, and belongs to the technical field of biomedical and textile materials. The double-drug-loaded negative Poisson ratio fabric dressing comprises double-drug-loaded hydrogel fibers, the double-drug-loaded hydrogel fibers comprise a first drug-loaded layer and a second drug-loaded layer, the first drug-loaded layer is loaded with antibacterial and anti-inflammatory drugs, the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, the second drug-loaded layer is loaded with anti-scarring drugs, and the double-drug-loaded hydrogel fibers are woven into a negative Poisson ratio fabric dressing. The antibacterial and anti-inflammatory drugs of the application can effectively inhibit wound infection, the anti-scarring drugs can avoid the generation of scars in the tissue regeneration process, and the negative Poisson ratio fabric characteristics can closely fit the wounds of complex parts such as human joints, can also be adaptively adjusted according to different wound shapes and sizes, and the shape adaptability of the fabric dressing is realized.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of biomedical and textile materials, and particularly relates to a double-drug-loaded negative Poisson's ratio fabric dressing and a preparation method thereof. BACKGROUND

[0002] As a medical product directly in contact with the wound, the performance of the wound dressing directly affects the healing effect of the wound and the comfort of the patient. With the continuous progress of medical technology, the requirements for wound dressings are also getting higher and higher. Not only is it required to have the basic functions of hemostasis and protection of the wound, but it is also required to intelligently respond to the wound environment, promote wound healing, and reduce scar formation.

[0003] Traditional wound treatment materials such as gauze and bandage can protect the wound and reduce infection to some extent, but they have obvious shortcomings in promoting wound healing, reducing scar formation, and adapting to complex skin curves. In recent years, with the rapid development of textile material science and biomedical technology, new types of wound treatment materials have emerged. Among them, hydrogel, as a material with excellent biocompatibility, high water absorption and water retention capacity, has attracted widespread attention in the fields of wound treatment, drug release and tissue engineering. The softness and moist environment of hydrogel help to maintain the moist environment of the wound, promote cell proliferation and migration, and thus accelerate wound healing. However, there are still some challenges in the preparation and application of existing hydrogel materials. On the one hand, how to precisely load drugs in hydrogel and achieve controlled release is the key to improving treatment effect; on the other hand, how to make hydrogel materials adapt to complex skin curves such as human joints and improve wearing comfort and treatment effect is also a technical problem to be solved. SUMMARY

[0004] The present application proposes a double-drug-loaded negative Poisson's ratio fabric dressing and a preparation method thereof, aiming to partially or completely solve the technical problems of how to achieve drug release and hydrogel materials adapting to complex skin curves such as joints in the prior art. By weaving double-drug-loaded hydrogel fibers into a fabric dressing with negative Poisson's ratio characteristics, it helps to achieve precise drug loading and controlled release, and can well adapt to complex skin curves such as human joints. The technical solution of the present application is as follows:

[0005] In a first aspect, a double-drug-loaded negative Poisson's ratio fabric dressing comprises: double-drug-loaded hydrogel fibers, the double-drug-loaded hydrogel fibers comprising a first drug-loaded layer and a second drug-loaded layer, the first drug-loaded layer loaded with an antibacterial and anti-inflammatory drug, the first drug-loaded layer formed on the outer surface of the second drug-loaded layer, the second drug-loaded layer loaded with an anti-scarring drug, and the double-drug-loaded hydrogel fibers woven into a negative Poisson's ratio fabric dressing.

[0006] Optionally, the loop density of the negative Poisson's ratio fabric dressing is 25-35 loops / inch along the first direction and 20-30 loops / inch along the second direction, the first direction and the second direction intersecting.

[0007] Optionally, the negative Poisson's ratio fabric dressing comprises a "zigzag" arranged space structure, and the loop length of the negative Poisson's ratio fabric dressing is greater than the loop width.

[0008] Optionally, the loop length is 5-10 mm and / or the loop width is 3-8 mm; the first drug-loaded layer comprises sodium alginate and polyvinyl alcohol, and the second drug-loaded layer comprises sodium alginate.

[0009] In a second aspect, a preparation method of a double-drug-loaded negative Poisson's ratio fabric dressing, the double-drug-loaded negative Poisson's ratio fabric dressing of any one of the above first aspect is prepared, comprising the following steps:

[0010] Step S100: preparing a double-drug-loaded hydrogel fiber using wet spinning;

[0011] Step S100 comprises:

[0012] Step S101: preparing a spinning solution containing an antibacterial anti-inflammatory drug;

[0013] Step S102: preparing a spinning solution containing an anti-scarring drug;

[0014] Step S103: the spinning solution containing the antibacterial anti-inflammatory drug is used as the first drug-loaded layer spinning solution, the spinning solution containing the anti-scarring drug is used as the second drug-loaded layer spinning solution, wet spinning is performed through a coaxial spinning nozzle, the solute of the coagulation bath in the wet spinning operation is calcium chloride, the solvent is deionized water, the concentration of the calcium chloride is 2%-10%; the spinning speed of the first drug-loaded layer spinning solution is controlled at 10-30 m / min, the spinning speed of the second drug-loaded layer spinning solution is controlled at 1-15 m / min, and the spinning temperature is controlled at 20-40°C, thereby obtaining the double-drug-loaded hydrogel fiber;

[0015] Steps S101 and S102 can be performed in sequence, in reverse sequence, or simultaneously.

[0016] Step S200: weaving the double-drug-loaded hydrogel fiber into a negative Poisson's ratio fabric dressing.

[0017] Optionally, step S101 comprises:

[0018] Sodium alginate and polyvinyl alcohol are used as the solute, deionized water is used as the solvent, the sodium alginate, the polyvinyl alcohol, and the deionized water are mixed to prepare a mixed solution with a total solute concentration of 2.5%-5%, the antibacterial anti-inflammatory drug is added to the mixed solution, and the spinning solution containing the antibacterial anti-inflammatory drug is prepared.

[0019] Optionally, step S102 comprises:

[0020] The sodium alginate and the deionized water are mixed to prepare a mixed solution with a total concentration of 1.5%-3% of the solute, the anti-scarring drugs are added into the mixed solution to prepare the spinning solution containing the anti-scarring drugs.

[0021] Optionally, step S200 comprises:

[0022] The double-drug-loaded hydrogel fibers are woven on the flat knitting machine, and the fabric dressing including the space structure in the zigzag arrangement is formed by alternately arranging the front and back loops, the loop density is 25-35 loops / inch along the first direction, the loop density is 20-30 loops / inch along the second direction, the yarn feeding speed is 10-30 m / min, the needle pitch is 10-14 needles / 25.2 mm, and the first direction and the second direction intersect.

[0023] Optionally, in step S101, the antibacterial and anti-inflammatory drugs include but are not limited to penicillin antibiotics, cephalosporin antibiotics, tetracycline antibiotics, and quinolone antibiotics; and in step S102, the anti-scarring drugs include but are not limited to silicone and glucocorticoid drugs.

[0024] The application has the following beneficial effects:

[0025] (1) In the application, the double-drug-loaded negative Poisson ratio fabric dressing includes the double-drug-loaded hydrogel fibers, the antibacterial and anti-inflammatory drugs and the anti-scarring drugs are respectively formed in the first drug-loaded layer and the second drug-loaded layer, the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, the double-drug-loaded hydrogel fibers can simultaneously carry the antibacterial and anti-inflammatory drugs and the anti-scarring drugs, can play a targeted role in different stages of wound healing, in the early stage of wound healing, the antibacterial and anti-inflammatory drugs are released from the first drug-loaded layer, the antibacterial and anti-inflammatory drugs can effectively resist bacterial infection at the wound, reduce inflammatory reaction, create a clean and stable microenvironment for wound healing, reduce the risk of infection, and effectively promote the wound healing process; when the wound healing enters the later stage, the anti-scarring drugs are gradually released from the second drug-loaded layer, the presence of the anti-scarring drugs can inhibit the excessive proliferation of scar tissue, help the smooth and beautiful appearance after wound healing, and greatly relieve the double adverse effects of scar on the physiological and psychological aspects of patients;

[0026] (2) In the present application, the negative Poisson's ratio fabric dressing has unique mechanical properties. When stretched, the transverse direction will expand, perfectly fitting the irregular wound contour of each part of the body, especially the complex skin surface such as human joints, ensuring that the fabric dressing and the wound are in close contact at all times, and adapting to different wound shapes and sizes, ensuring perfect fitting of the fabric dressing to the wound, realizing shape adaptability. Moreover, this close fitting can prevent external pollutants from entering, enhancing the protection of the wound, allowing the drug to be released uniformly and continuously at the wound site, improving the sustained-release effect and utilization of the drug at the wound site, and providing a more ideal microenvironment for wound healing, significantly accelerating the wound repair process, and significantly optimizing and improving the comprehensive performance and wound treatment effect of the dressing in wound treatment; BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0028] Figure 1 The structure diagram of the double-drug-loaded hydrogel fiber of the present application.

[0029] Figure 2 The structure diagram of a double-drug-loaded negative Poisson's ratio fabric dressing of the present application.

[0030] Figure 3 The preparation method flowchart of a double-drug-loaded negative Poisson's ratio fabric dressing of the present application.

[0031] The accompanying drawings are used to provide a further understanding of the present application, and constitute a part of the specification, together with the embodiments of the present application, to explain the present application, and do not constitute a limitation of the present application. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0033] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. "Include" can be understood at least as the meaning of only including. In order to make the purpose, technical scheme and advantages of the present application clearer, the embodiments of the present application will be further described in detail below with reference to the drawings.

[0034] In a first aspect, a dual drug-loaded negative Poisson's ratio fabric dressing comprises: a dual drug-loaded hydrogel fiber, the dual drug-loaded hydrogel fiber comprising a first drug-loaded layer 100 and a second drug-loaded layer 200, the first drug-loaded layer loaded with an antibacterial anti-inflammatory drug, the first drug-loaded layer formed on the outer surface of the second drug-loaded layer, the second drug-loaded layer loaded with an anti-scarring drug, the dual drug-loaded hydrogel fiber woven into a negative Poisson's ratio fabric dressing.

[0035] In the present application, first, the double-drug-loaded negative Poisson's ratio fabric dressing includes double-drug-loaded hydrogel fibers, antibacterial anti-inflammatory drugs and anti-scarring drugs respectively formed in the first drug-loaded layer and the second drug-loaded layer, the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, the double-drug-loaded hydrogel fibers can simultaneously load antibacterial anti-inflammatory drugs and anti-scarring drugs, and can sequentially play a targeted role in different stages of wound healing. In the early stage of wound healing, the antibacterial anti-inflammatory drugs are released from the first drug-loaded layer, the antibacterial anti-inflammatory drugs can effectively resist bacterial infection at the wound, reduce inflammatory response, create a clean and stable microenvironment for wound healing, reduce the risk of infection, and effectively promote the acceleration of wound healing process; when the wound healing enters the later stage, the anti-scarring drugs are gradually released from the second drug-loaded layer, the presence of the anti-scarring drugs can inhibit the excessive proliferation of scar tissue, help the smooth and aesthetic appearance after wound healing, and greatly alleviate the double adverse effects of scar on the physiological and psychological aspects of patients; in addition, the negative Poisson's ratio fabric dressing has unique mechanical properties, when stretched under stress, the transverse direction will expand, which can perfectly fit the irregular wound contour of each part of the body, especially can well adapt to complex skin curves such as human joints, and ensure that the fabric dressing and the wound always maintain close contact state, and adapt to different wound shapes and sizes to ensure perfect fit between the fabric dressing and the wound, realizing the shape adaptability of the fabric dressing. Moreover, such close fitting can also prevent external pollutants from entering, enhance the protection of the wound, and facilitate the uniform and continuous release of the drugs at the wound site, improve the sustained-release effect and utilization rate of the drugs at the wound, and also provide a more ideal microenvironment for wound healing, realize the significant acceleration of wound repair process, and significantly optimize and improve the comprehensive performance and wound treatment effect of the dressing in wound treatment.

[0036] Optionally, along the first direction, the stitch density of the negative Poisson's ratio fabric dressing is 25-35 stitches / inch, along the second direction, the stitch density of the negative Poisson's ratio fabric dressing is 20-30 stitches / inch, and the first direction and the second direction intersect.

[0037] In the present application, firstly, the first direction has 25-35 coils / inch, and the second direction has 20-30 coils / inch, the coil density distribution of the first direction and the second direction makes the fabric dressing have suitable elasticity in different directions, maintains the structural stability of the fabric dressing during use, and different combinations of coil density arrangement can make the fabric dressing better fit the curves of different parts of the human body, whether the fabric dressing is bent or stretched, which can make the fabric dressing closely fit the wound and provide good fitting effect. In addition, the coil density distribution of the first direction and the second direction helps to adjust the air permeability of the fabric dressing, so that the wound is in a suitable microenvironment, which is conducive to wound healing. It should be noted that the first direction and the second direction intersect, the first direction can be the transverse direction (i.e. the X direction) of the negative Poisson's ratio fabric dressing, and the second direction can be the longitudinal direction (i.e. the Y direction) of the negative Poisson's ratio fabric dressing, and the first direction and the second direction can be perpendicular. Figure 2 Figure 2

[0038] Optionally, the negative Poisson's ratio fabric dressing comprises a "zigzag" arrangement of space structures, and the coil length of the negative Poisson's ratio fabric dressing is greater than the coil width.

[0039] In the present application, the "zigzag" arrangement of space structures makes the dressing have good elasticity and flexibility, when subjected to external force stretching, the "zigzag" structure can effectively disperse stress and avoid stress concentration, thereby reducing the risk of fabric dressing rupture, and the design of the coil length being greater than the coil width increases the deformability of the fabric in the stretching direction, so that the fabric dressing can better adapt to wounds of different shapes and sizes, closely fit the wound surface, effectively prevent the invasion of external bacteria, and also enhance the air permeability of the fabric dressing, creating a good healing environment for the wound and helping the wound to recover faster.

[0040] Optionally, the coil length is 5-10mm, and / or the coil width is 3-8mm.

[0041] In the present application, the setting of the coil length helps the dressing to have enough margin to adapt to different degrees of deformation when stretched, such as when wrapping joints and other active parts, it can flexibly change with the bending and stretching of the limbs, and will not be too tight or loose. The range of coil width can ensure that the fabric has good supportability, can maintain a stable structure when covering the wound, and at the same time can make the dressing maintain appropriate air permeability, which is conducive to air exchange of the wound and promotes wound healing.

[0042] Optionally, the first drug-loaded layer comprises sodium alginate and polyvinyl alcohol, and the second drug-loaded layer comprises sodium alginate.

[0043] ​​In the present application, firstly, the application of sodium alginate in the first drug-loaded layer and the second drug-loaded layer helps to load and release the drug. Sodium alginate has good biocompatibility and can avoid stimulating the wound. Sodium alginate can form a gel-like structure, effectively adsorb the drug and control the release rate of the drug, so that the drug can continuously and stably act on the wound. In addition, the polyvinyl alcohol in the first drug-loaded layer cooperates with the sodium alginate to improve the mechanical properties of the first drug-loaded layer. The polyvinyl alcohol can make the first drug-loaded layer more firm and not easy to break during the use of the fabric dressing, thereby better playing the effects of drug loading and treatment.

[0044] In a second aspect, a preparation method of a double-drug-loaded negative Poisson's ratio fabric dressing is provided. The method is used to prepare the double-drug-loaded negative Poisson's ratio fabric dressing of any one of the first aspect, and includes the following steps.

[0045] Step S100: preparing a double-drug-loaded hydrogel fiber by using a wet spinning method;

[0046] Specifically, step S100 includes:

[0047] Step S101: preparing a spinning solution containing an antibacterial and anti-inflammatory drug;

[0048] Specifically, step S101 includes:

[0049] Sodium alginate and polyvinyl alcohol are used as solutes, and deionized water is used as a solvent. The sodium alginate, the polyvinyl alcohol, and the deionized water are mixed to prepare a mixed solution with a total solute concentration of 2.5%-5%. The antibacterial and anti-inflammatory drug is added to the mixed solution to prepare a spinning solution containing the antibacterial and anti-inflammatory drug. For example, the total solute concentration is 3.5%, and the antibacterial and anti-inflammatory drug is ofloxacin with a drug concentration of 0.3%.

[0050] In step S101, the mixed solution with a specific concentration is prepared by using sodium alginate and polyvinyl alcohol as solutes and deionized water as a solvent, which can ensure that the spinning solution has appropriate viscosity and spinning performance, and is conducive to the stable performance of the subsequent spinning process. The combination of sodium alginate and polyvinyl alcohol not only gives the spinning solution good biocompatibility, but also enhances the mechanical strength of the spinning solution, so that the formed fiber is tough and not easy to break. The addition of ofloxacin as an antibacterial and anti-inflammatory drug and the control of the concentration to 0.3% can effectively kill bacteria and reduce inflammation while avoiding adverse reactions caused by excessive drugs, precisely acting on the wound, and promoting wound healing and recovery.

[0051] Step S102: preparing a spinning solution containing an anti-scarring drug;

[0052] Specifically, step S102 includes:

[0053] Sodium alginate is used as a solute, and deionized water is used as a solvent. The sodium alginate and the deionized water are mixed to prepare a mixed solution with a total solute concentration of 1.5%-3%. The anti-scarring drug is added to the mixed solution to prepare a spinning solution containing the anti-scarring drug. For example, the total solute concentration is 2%, the anti-scarring drug is triamcinolone acetonide, and the drug concentration is 20 g / L.

[0054] In step S102, first, sodium alginate is used as a solute, and deionized water is used as a solvent to prepare a mixed solution with a specific concentration, which provides a good basis for spinning. The good biocompatibility of sodium alginate can reduce the irritation to the human body, and the appropriate concentration ensures the stability of the spinning solution. Second, triamcinolone acetonide is added as an anti-scarring drug, and when the concentration is 20 g / L, it can effectively inhibit the proliferation of fibroblasts and other processes related to scar formation, precisely acting in the wound healing stage and reducing the probability of scar formation. At the same time, the preparation method of the spinning solution is beneficial to the uniform distribution of the drug in the fiber, allowing the drug to be released continuously and stably, thereby improving the anti-scarring treatment effect.

[0055] It should be noted that steps S101 and S102 can be performed in sequence, in reverse sequence, or simultaneously.

[0056] Step S103: The spinning solution containing the antibacterial and anti-inflammatory drug is used as the first drug-loaded layer spinning solution, and the spinning solution containing the anti-scarring drug is used as the second drug-loaded layer spinning solution. Wet spinning is performed through a coaxial spinning nozzle. The solute of the coagulation bath in the wet spinning operation is calcium chloride, and the solvent is deionized water. The concentration of calcium chloride is 2%-10%. The spinning speed of the first drug-loaded layer spinning solution is controlled at 10-30 m / min, and the spinning speed of the second drug-loaded layer spinning solution is controlled at 1-15 m / min. The spinning temperature is controlled at 20-40℃. A double-drug-loaded hydrogel fiber is prepared.

[0057] In step S103, first, a double-drug-loaded layer structure is realized through a coaxial spinning nozzle, which can precisely position the antibacterial and anti-inflammatory drug and the anti-scarring drug in the first drug-loaded layer and the second drug-loaded layer, respectively, so that the two drugs can play a role in different stages of wound healing. In the coagulation bath section, calcium chloride as a solute can effectively coagulate the spinning solution, and its concentration range ensures good fiber formation. The control of the spinning speed and temperature makes the fiber formation process more stable and uniform, effectively avoiding defects such as uneven thickness of the fiber. The finally prepared double-drug-loaded hydrogel fiber can provide sustained antibacterial and anti-inflammatory function while considering the anti-scarring function, which is beneficial to the better recovery of the wound.

[0058] Step S200: Weave the double-drug-loaded hydrogel fiber into a negative Poisson ratio fabric dressing.

[0059] Specifically, step S200 includes:

[0060] The double-drug-loaded hydrogel fiber is woven on a flat knitting machine, and the fabric dressing is formed by alternately arranging the positive and negative loops to form a space structure in the shape of a "Z". The loop density is 25-35 loops / inch along a first direction and 20-30 loops / inch along a second direction, and the first direction intersects the second direction.

[0061] Exemplarily, the flat knitting machine is a CMS 530HP computer flat knitting machine, the double-drug-loaded hydrogel fiber is woven by the CMS 530HP computer flat knitting machine, the fabric dressing is formed by alternately arranging the positive and negative loops, the yarn feeding speed is 10-30 m / min, the needle pitch is 10-14 needles / 25.2 mm, the loop density is 25-35 loops / inch in the transverse direction along the first direction and 20-30 loops / inch along the second direction, the loop length is 8 mm, the loop width is 6 mm, the yarn diameter is 0.2 mm, the loop density in the first direction is 25 loops / inch, and the loop density in the second direction is 25 loops / inch.

[0062] In the present application, the double-drug-loaded hydrogel fiber is woven on a flat knitting machine to form a fabric dressing, and the space structure in the shape of a "Z" is combined with a specific loop density to make the fabric dressing have good elasticity and fit in different directions, so as to tightly wrap the wound and adapt to complex skin curves such as human joints; the structural parameters of the fabric dressing include loop length, width, yarn diameter, etc., which ensure the stability of the fabric dressing structure, neither too loose to affect the drug effect, nor too tight to hinder the ventilation, so that the antibacterial, anti-inflammatory and anti-scarring drugs can precisely act on the wound, create a favorable healing environment for the wound, promote tissue repair, and reduce complications.

[0063] Optionally, in step S101, the antibacterial and anti-inflammatory drugs include but are not limited to penicillin antibiotics, cephalosporin antibiotics, tetracycline antibiotics, and quinolone antibiotics; in step S102, the anti-scarring drugs include but are not limited to silicone and glucocorticoid drugs.

[0064] In the present application, for the antibacterial and anti-inflammatory drugs, different types such as penicillin and cephalosporin can play a role against a variety of bacteria, effectively killing various bacteria that cause wound infection, reducing inflammation, and preventing infection from spreading; at the same time, the silicone and glucocorticoid drugs in the anti-scarring drugs can inhibit scar formation from different mechanisms, respectively, the silicone can improve the appearance of the scar, and the glucocorticoid can regulate cell activity and reduce the excessive proliferation of collagen fibers. Therefore, the multiple drug combination scheme can be flexibly adjusted according to the specific condition, constitution and allergy history of the patient, etc., to improve the targeting and effectiveness of the treatment.

[0065] Thus, in the present application, the dual-drug hydrogel fibers are prepared by wet spinning technology, realizing the precise loading and release of antibacterial, anti-inflammatory and anti-scarring drugs, improving the sustained-release effect and utilization rate of drugs at the wound site, and also providing a more ideal microenvironment for wound healing, achieving a significant acceleration of the wound repair process; the design of the negative Poisson's ratio knitted structure enables the transverse size of the fabric dressing to increase moderately when stretched, thereby better fitting the skin, especially complex body surface shapes such as human joints, not only improving the fit and comfort of the fabric dressing, but also helping to reduce friction and pressure at the wound site, promoting wound healing, and also being able to adapt to different wound shapes and sizes, ensuring perfect fit of the fabric dressing to the wound, realizing the shape adaptability of the fabric dressing.

[0066] The embodiment shown in the drawings is only one of the embodiments of the present application, and the actual structure is not limited thereto. In general, if a person skilled in the art is inspired by it, without departing from the purpose of the present application, similar structural modes and embodiments can be designed without creativity, which should belong to the protection scope of the present application.

Claims

1. A dual drug-loaded negative poisson's ratio fabric dressing characterized in that, The double-drug-loaded hydrogel fiber prepared by coaxial wet spinning and a negative Poisson's ratio knitted structure knitted by the double-drug-loaded hydrogel fiber; The double-drug-loaded hydrogel fiber is a coaxial core-shell structure, the outer layer is a first drug-loaded layer, and the inner layer is a second drug-loaded layer; The first drug-loaded layer is formed on the outer surface of the second drug-loaded layer and comprises sodium alginate and polyvinyl alcohol and carries an antibacterial and anti-inflammatory drug; The second drug-loaded layer comprises sodium alginate and carries an anti-scarring drug; the negative Poisson's ratio knitted structure is a zigzag folding structure formed by alternately arranging positive and negative loops, and the loop length is greater than the loop width, wherein the loop density along a first direction is 25-35 loops / inch, and the loop density along a second direction is 20-30 loops / inch, and the first direction intersects the second direction; The loop length is 5-10 mm, and the loop width is 3-8 mm; the coaxial wet spinning uses deionized water as a solvent, CaCl2 as a solute of a coagulation bath, and the concentration is 2%-10%.

2. The dressing of claim 1, wherein, The antibacterial and anti-inflammatory drug in the first drug-loaded layer is at least one selected from penicillins, cephalosporins, tetracyclines, or quinolones.

3. The dressing of claim 1, wherein, The anti-scarring drug in the second drug-loaded layer is at least one selected from silicones or glucocorticoids.

4. The dressing of claim 1, wherein, In the coaxial wet spinning process, the spinning speed of the first drug-loaded layer spinning solution is 10-30 m / min, the spinning speed of the second drug-loaded layer spinning solution is 1-15 m / min, and the spinning temperature is 20-40℃.

5. The dressing of claim 1, wherein, The negative Poisson's ratio knitted structure is formed by a flat knitting process, the yarn feeding speed is 10-30 m / min, and the needle pitch is 10-14 needles / 25.2 mm.

6. The dressing of claim 1, wherein, The yarn diameter of the double-drug-loaded hydrogel fiber is 0.2 mm.

7. A method of manufacturing a dressing according to any of the claims 1 - 6, characterized in that, It comprises: (1) preparing a first drug-loaded layer spinning solution: taking sodium alginate and polyvinyl alcohol as a solute, deionized water as a solvent, and adding an antibacterial and anti-inflammatory drug to obtain a first drug-loaded layer spinning solution; (2) preparing a second drug-loaded layer spinning solution: taking sodium alginate as a solute, deionized water as a solvent, and adding an anti-scarring drug to obtain a second drug-loaded layer spinning solution; (3) wet spinning through a coaxial spinning nozzle, so that the first drug-loaded layer is formed on the outer surface of the second drug-loaded layer, and the coaxial core-shell double-drug-loaded hydrogel fiber is formed in a coagulation bath with a CaCl2 concentration of 2%-10%, and the spinning speeds of the first drug-loaded layer and the second drug-loaded layer are controlled to be 10-30 m / min and 1-15 m / min, respectively, and the spinning temperature is 20-40℃; (4) using a flat knitting process to knit the double-drug-loaded hydrogel fiber into a zigzag folding structure with alternately arranged positive and negative loops, and the loop length is 5-10 mm, the loop width is 3-8 mm, and the loop densities along the first direction and the second direction are 25-35 and 20-30 loops / inch, respectively.

8. The method of claim 7, wherein, The antibacterial and anti-inflammatory drug in step (1) is at least one selected from penicillins, cephalosporins, tetracyclines, or quinolones; and the anti-scarring drug in step (2) is at least one selected from silicones or glucocorticoids.

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