Composition with effects of controlling oil and removing acnes and application thereof

By using compositions of salicylic acid, azelaic acid, succinic acid, oil palm extract, purple chrysanthemum extract and Yangweiling cabbage root extract, the existing acne-removing skin care products have been solved, and significant oil control and acne removal effects and safety have been achieved.

CN119732851APending Publication Date: 2025-04-01GUANGDONG BAWEI BIOLOGICAL TECH CO LTD +1

Patent Information

Application Number
CN202510189277.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-20
Publication Date
2025-04-01

AI Technical Summary

Technical Problem

Existing acne-removing skin care products have poor results and may cause allergic reactions, making it difficult to effectively control oil and remove acne.

Method used

Compositions of components such as salicylic acid, azelaic acid, succinic acid, oil palm extract, purple chrysanthemum extract and Yangweiling cabbage root extract are used to reduce the expression of inflammatory factors, reduce sebum secretion and inhibit bacterial effects, and achieve the effect of controlling oil and removing acne.

Benefits of technology

This composition significantly reduces the volume of acne, inhibits the growth of a variety of poxacin-causing strains, significantly reduces oil secretion, has significant oil control and acne removal effects, and is gentle and safe, with a wide range of applications.

✦ Generated by Eureka AI based on patent content.
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Abstract

The invention discloses a composition with oil-controlling and acne-removing effects, which is prepared from the following components in parts by weight: 1 to 2 parts of salicylic acid, 0.01 to 0.2 part of azelaic acid, 0.01 to 0.2 part of succinic acid, 1 to 30 parts of oil palm extract, 1 to 30 parts of chrysanthemum violaceum extract, 1 to 30 parts of potentilla chinensis root extract and 50 to 100 parts of deionized water, and also provides application of the composition. According to the composition provided by the invention, various components have a synergistic effect, the efficacy can be further improved, the composition has an inhibiting effect on various strains such as pseudomonas aeruginosa, escherichia coli, staphylococcus aureus and propionibacterium acnes, meanwhile, the volume of acnes can be remarkably reduced, grease secretion can be remarkably reduced, the oil control and acne removal effects are remarkable, and the composition is free of toxic and side effects. Meanwhile, the traditional Chinese medicine composition is mild and safe, is suitable for a wide range of people, does not need to establish skin tolerance, is more easily accepted by consumers, and has a good application prospect and a wide market.
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Description

Technical Field

[0001] The invention discloses a composition and application thereof, in particular, a composition with oil-controlling and acne-removing effects and application thereof, belonging to the technical field of cosmetics. Background Art

[0002] The formation of acne is often the result of the combined effects of multiple factors, mainly related to genetic factors, endocrine factors, facial hygiene, eating habits, long-term mental stress, mood swings, learning and living environment, etc. These factors can easily lead to sebum metabolism disorders, excessive skin oil secretion, excessive keratinization of hair follicles and sebaceous glands, narrowing and occluding the hair follicle openings, allowing microorganisms to breed and gather in large numbers, thus causing inflammation, and ultimately leading to acne and pimples. Therefore, oil control and acne removal are currently the two important ways to treat such skin problems. The purpose of oil control is to regulate skin oil secretion and restore the physiological balance of the skin, thereby preventing and solving acne problems from the root; the purpose of acne removal is to inhibit the growth of microorganisms and unclog pores, thereby improving acne and pimples that have already caused skin inflammation.

[0003] Currently, anti-acne skin care products are mainly made of Chinese herbal medicine or synthetic raw materials that can kill bacteria, reduce inflammation, remove redness, and soothe the skin. The dosage forms are mainly water-based, essence, and cream. The use process is light and comfortable, but there is a general disadvantage of poor effect, and some consumers may even experience allergic side effects.

[0004] Therefore, it is very necessary to develop an oil-controlling and acne-removing composition with small side effects and quick effects to solve the problems caused by acne for consumers. Summary of the invention

[0005] In view of the above-mentioned deficiencies, the purpose of the present invention is to provide a composition with oil control and acne removal effects, which can effectively reduce the expression of inflammatory factors, eliminate inflammation, reduce sebum secretion and inhibit bacteria, thereby achieving the effect of oil control and acne removal. At the same time, a preparation method of the composition is also provided.

[0006] To this end, the first technical solution provided by the present invention is as follows:

[0007] A composition with oil-controlling and acne-removing effects, characterized in that it is composed of the following ingredients in parts by weight: 1-2 parts of salicylic acid, 0.01-0.2 parts of azelaic acid, 0.01-0.2 parts of succinic acid, 1-30 parts of oil palm extract, 1-30 parts of purple chrysanthemum extract, 1-30 parts of Potentilla officinalis root extract and 50-100 parts of deionized water.

[0008] Furthermore, it is composed of the following ingredients in parts by weight: 1-1.5 parts of salicylic acid, 0.01-0.15 parts of azelaic acid, 0.01-0.15 parts of succinic acid, 1-20 parts of oil palm extract, 1-20 parts of purple chrysanthemum extract, 1-20 parts of Potentilla root extract and 50-80 parts of deionized water.

[0009] Furthermore, it is composed of the following ingredients in parts by weight: 1 part of salicylic acid, 0.1 part of azelaic acid, 0.1 part of succinic acid, 15.5 parts of oil palm extract, 15.5 parts of purple chrysanthemum extract, 15.5 parts of Potentilla officinalis root extract and 75 parts of deionized water.

[0010] The second technical solution provided by the invention is: an application of the above composition, wherein the composition is applied in the preparation of cosmetics.

[0011] Furthermore, the composition is used in oil-controlling and acne-removing cosmetics.

[0012] Furthermore, the oil-controlling and anti-acne cosmetic is a skin external preparation prepared by using the composition with oil-controlling and anti-acne effects as an active component and adding conventional pharmaceutical or cosmetic excipients or auxiliary ingredients.

[0013] Furthermore, the added amount of the composition with oil-controlling and acne-removing effects in the oil-controlling and acne-removing cosmetic is 0.01-10%.

[0014] Furthermore, the oil-controlling and anti-acne cosmetics are one or more of lotions, essences, creams, facial masks, and gels.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] 1. The composition provided by the present invention is composed of salicylic acid, azelaic acid, succinic acid, oil palm extract, purple hairy chrysanthemum extract and Potentilla officinalis root extract. The multiple ingredients work synergistically to achieve the effect of controlling oil and removing acne.

[0017] 2. The multiple ingredients of the composition provided by the present invention work synergistically to further enhance the efficacy, and have inhibitory effects on multiple strains such as Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Propionibacterium acnes. At the same time, it can significantly reduce the volume of acne and the secretion of oil, and has a significant effect of controlling oil and removing acne.

[0018] 3. The composition provided by the present invention is mild and safe, applicable to a wider population, and does not require the establishment of skin tolerance, so it is more easily accepted by consumers and has good application prospects and a broad market. DETAILED DESCRIPTION

[0019] The following is a further detailed description of the claims of the present invention in conjunction with specific implementation methods, but does not constitute any limitation to the present invention. Any limited modifications made by anyone within the scope of protection of the claims of the present invention are still within the scope of protection of the claims of the present invention.

[0020] Example 1

[0021] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1g of salicylic acid, 0.01g of azelaic acid, 0.01g of succinic acid, 1g of oil palm extract, 1g of chrysanthemum purpurogenum extract, 1g of Potentilla officinalis root extract and 50g of deionized water.

[0022] Example 2

[0023] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1 g of salicylic acid, 0.1 g of azelaic acid, 0.1 g of succinic acid, 15.5 g of oil palm extract, 15.5 g of chrysanthemum purpurogenum extract, 15.5 g of Potentilla officinalis root extract and 75 g of deionized water.

[0024] Example 3

[0025] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1.5 g of salicylic acid, 0.15 g of azelaic acid, 0.15 g of succinic acid, 20 g of oil palm extract, 20 g of chrysanthemum purpurogenum extract, 20 g of Potentilla officinalis root extract and 80 g of deionized water.

[0026] Example 4

[0027] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 2 g of salicylic acid, 0.2 g of azelaic acid, 0.2 g of succinic acid, 30 g of oil palm extract, 30 g of chrysanthemum purpurogenum extract, 30 g of Potentilla officinalis root extract and 100 g of deionized water.

[0028] In order to demonstrate the effect of the present invention, the following comparative experimental examples are given:

[0029] Comparative Example 1

[0030] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 0.1 g of azelaic acid, 0.1 g of succinic acid, 15.5 g of oil palm extract, 15.5 g of chrysanthemum purpurogenum extract, 15.5 g of Potentilla officinalis root extract and 75 g of deionized water.

[0031] Comparative Example 2

[0032] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1 g of salicylic acid, 0.1 g of succinic acid, 15.5 g of oil palm extract, 15.5 g of chrysanthemum morifolium extract, 15.5 g of Potentilla officinalis root extract and 75 g of deionized water.

[0033] Comparative Example 3

[0034] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1 g of salicylic acid, 0.1 g of azelaic acid, 15.5 g of oil palm extract, 15.5 g of chrysanthemum morifolium extract, 15.5 g of Potentilla officinalis root extract and 75 g of deionized water.

[0035] Comparative Example 4

[0036] A composition with oil-controlling and acne-removing effects, composed of the following components by weight: 1 g of salicylic acid, 0.1 g of azelaic acid, 0.1 g of succinic acid, 15.5 g of acanthus purpurea extract, 15.5 g of a potentilla root extract and 75 g of deionized water.

[0037] Comparative Example 5

[0038] A composition with oil-controlling and acne-removing effects, comprising the following components by weight: 1 g of salicylic acid, 0.1 g of azelaic acid, 0.1 g of succinic acid, 15.5 g of oil palm extract, 15.5 g of Potentilla officinalis root extract and 75 g of deionized water.

[0039] Comparative Example 6

[0040] A composition with oil-controlling and acne-removing effects consists of the following components by weight: 1 g of salicylic acid, 0.1 g of azelaic acid, 0.1 g of succinic acid, 15.5 g of oil palm extract, 15.5 g of chrysanthemum purpurogenum extract and 75 g of deionized water.

[0041] Table 1. Composition table of examples and comparative examples

[0042] Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Salicylic acid / g 1 1 1.5 2 0 1 1 1 1 1 Azelaic acid / g 0.01 0.1 0.15 0.2 0.1 0 0.1 0.1 0.1 0.1 Succinic acid / g 0.01 0.1 0.15 0.2 0.1 0.1 0 0.1 0.1 0.1 Oil palm extract / g 1 15.5 20 30 15.5 15.5 15.5 0 15.5 15.5 Purple Hairy Chrysanthemum Extract / g 1 15.5 20 30 15.5 15.5 15.5 15.5 0 15.5 Potentilla officinalis root extract / g 1 15.5 20 30 15.5 15.5 15.5 15.5 15.5 0 Deionized water 50 75 80 100 75 75 75 75 75 75

[0043] In order to better illustrate the advantages of the present invention, the verification scheme provided by the present invention is given below:

[0044] 1. Antibacterial experiment

[0045] The test was conducted in accordance with the “Test Method for Antibacterial Performance of Dissolution Antibacterial (Inhibitory) Products” described in “Study on Evaluation Method of Anti-Acne Effectiveness of Anti-Acne Cosmetics” (Daily Chemicals Science, Vol. 27, No. 12, December 2004).

[0046] 1.1、Operation steps:

[0047] (1) 24 h (bacteria) and 5 days (fungi) cultures of the experimental bacteria were washed with 0.03 mol / L PBS to prepare a 10^6 cfu / mL bacterial suspension.

[0048] (2) Take 1g of the test sample and add 0.1mL of the above bacterial suspension to evenly spread and mix. After 20 minutes of timing, add 9mL of 0.03mol / L PBS and mix thoroughly. After appropriate dilution, take 2-3 dilutions and place 1mL in two parallel flat dishes. Then add the corresponding culture medium and mix and culture. Count the colonies. Repeat the above test 3 times and take the average. Set up a blank control at the same time.

[0049] Calculation: X=(AB) / A*100%,

[0050] In the formula: X—inhibition rate, %; A—average colonies recovered from control samples; B—average colonies recovered from test samples.

[0051] 1.2 Results Analysis

[0052] The results show that the antibacterial rate is 50-90%, and the product has an antibacterial effect; the antibacterial rate is greater than 90%, and the product has a strong antibacterial effect.

[0053] The efficacy evaluation of acne removal is divided into three levels: markedly effective, effective and ineffective. When the antibacterial rate of the sample against various bacteria reaches ≥90%, it is judged to be significantly effective in preventing and inhibiting the occurrence of acne; when the antibacterial rate of the sample against various bacteria reaches ≥50% to 90%, it is judged to have a certain effect on preventing and inhibiting the occurrence of acne; when the antibacterial rate of the sample against various bacteria reaches <50%, it is judged to be ineffective.

[0054] Table 2. Antibacterial test results

[0055] Bacteria Pseudomonas aeruginosa Escherichia coli Staphylococcus aureus Propionibacterium acnes Evaluation of antibacterial effect Example 1 85% 93% 96% 94% efficient Example 2 97% 94% 98% 97% Significant Example 3 94% 95% 98% 97% Significant Example 4 98% 96% 99% 97% Significant Comparative Example 1 48% 46% 47% 39% invalid Comparative Example 2 38% 36% 42% 45% invalid Comparative Example 3 43% 41% 38% 47% invalid Comparative Example 4 48% 36% 38% 44% invalid Comparative Example 5 35% 39% 46% 47% invalid Comparative Example 6 42% 45% 47% 38% invalid

[0056] From the data in Table 2, it can be seen that the skin care products of Examples 1, 2, 3, and 4 are effective against the four bacterial species, among which the inhibition rates of Examples 2, 3, and 4 against the four bacterial species are greater than 90%, which are significant effects. This indicates that the skin care products prepared by adding the composition with acne removal effect of the present invention can significantly and effectively prevent and inhibit the occurrence of acne. The antibacterial rates of Comparative Examples 1-6 against the four bacterial species are relatively low, indicating that the various components in the technical solution of the present invention synergistically exert an antibacterial effect, and the lack of any one of them will significantly reduce the antibacterial effect.

[0057] 2. Human acne removal efficacy test

[0058] 2.1 Experimental Design

[0059] Single-blind, self-controlled before and after

[0060] 2.2. Test Purpose and Principle

[0061] The acne removal effect of the test samples was evaluated by comparing the acne volumes of the subjects before and after use of 40 healthy Chinese subjects for 14 consecutive days.

[0062] 2.3. Usage

[0063] After cleansing in the morning and evening, take an appropriate amount of sample and gently pat on the areas that need care (face, acne areas) until absorbed.

[0064] 2.4 Test Location

[0065] Cheeks, acne areas

[0066] 2.5 Test equipment and parameters

[0067] Table 3. Equipment and parameter table

[0068] Serial number Test indicators Test instruments and methods Test site 1 Acne volume Antera3D facial camera analyzer uses before and after images to analyze acne volume Acne area

[0069] 2.6 Statistical methods (data analysis)

[0070] SPSS was used as the statistical analysis software. Shapiro-Wilk Test was used to test the significance of the normal distribution of the data improvement value. If Sig. (bilateral) > 0.01, it was normally distributed and a paired t test was performed. If Sig. (bilateral) < 0.01, it was non-normally distributed and a Wilcoxon test was performed.

[0071] If P>0.05, it means there is no significant difference, which is recorded as "ns";

[0072] If P < 0.05, it means there is a significant difference, and 0.01 ≤ P < 0.05, it is recorded as "*"; 0.001 ≤ P < 0.01, it is recorded as "**"; p < 0.001, it is recorded as: "***".

[0073] Change rate (percentage) = (mean value of data after use - mean value of data before use) * 100% / mean value of data before use.

[0074] 2.7. Results and analysis (the larger the negative value of the change rate, the more obvious the effect)

[0075] Table 4. Change rate of acne volume of subjects

[0076] Acne volume change rate % (mm^3) Before use (D0) After use (D7) After use (D14) P-value Acne Treatment Reviews Example 1 0 -41.36 -65.83 <0.001 efficient Example 2 0 -43.62 -60.34 <0.001 efficient Example 3 0 -44.92 -67.56 <0.001 efficient Example 4 0 -48.74 -68.35 <0.001 efficient Comparative Example 1 0 -3.32 -5.76 >0.05 invalid Comparative Example 2 0 -3.61 -5.87 >0.05 invalid Comparative Example 3 0 -3.25 -5.81 >0.05 invalid Comparative Example 4 0 -3.41 -5.64 >0.05 invalid Comparative Example 5 0 -3.72 -5.13 >0.05 invalid Comparative Example 6 0 -4.37 -3.25 >0.05 invalid

[0077] It can be seen from the test results in Table 4 that Examples 1, 2, 3, and 4 can significantly reduce the volume of acne, indicating that the skin care products prepared by adding the composition with acne removal effect of the present invention can significantly and effectively prevent and inhibit the occurrence of acne. Comparative Examples 1-6 cannot significantly reduce the volume of acne, indicating that the various components in the technical solution of the present invention work together to remove acne, and the lack of any one of them will significantly reduce the acne removal effect.

[0078] 3. Human body oil control efficacy test

[0079] 3.1. Test method and theoretical basis:

[0080] According to the laboratory internal method "YZTQWP250 Oil Control Human Efficacy Test Method"

[0081] 3.2 Experimental Design

[0082] Single-blind, self-controlled, blank-controlled

[0083] 3.3 Experimental Purpose and Principle

[0084] The oil-control effect of the product was verified by having 40 subjects with oily skin use the samples on their entire faces, testing the oil content of the skin before and after application and comparing the results with their own skin before use.

[0085] 3.4. Usage

[0086] After cleansing in the morning and evening, apply an appropriate amount of sample to the entire face and pat gently until absorbed.

[0087] 3.5 Test Location

[0088] Forehead

[0089] 3.6 Test equipment and parameters

[0090] Table 5. Equipment and parameter table

[0091] Serial number Test indicators Test instruments and methods Test site Testing time 1 Skin oils Skin oil tester SM815, measure for 30 seconds and take the average value Forehead 3 times (D0, D14, D28)

[0092] 3.7 Statistical methods (data analysis)

[0093] SPSS was used as the statistical analysis software. Shapiro-Wilk Test was used to test the significance of the normal distribution of the data improvement value. If Sig. (bilateral) > 0.01, it was normally distributed and a paired t test was performed. If Sig. (bilateral) < 0.01, it was non-normally distributed and a Wilcoxon test was performed.

[0094] If P>0.05, it means there is no significant difference, which is recorded as "ns";

[0095] If P < 0.05, it means there is a significant difference, and 0.01 ≤ P < 0.05, it is recorded as "*"; 0.001 ≤ P < 0.01, it is recorded as "**"; p < 0.001, it is recorded as: "***".

[0096] Change rate (percentage) = (mean value of data after use - mean value of data before use) * 100% / mean value of data before use.

[0097] 3.8 Statistical results and analysis

[0098] Table 6. Change rate of fat content in subjects (the larger the negative value of the change rate, the more obvious the effect)

[0099] <![CDATA[Percentage change rate of skin oil content (%) (μg / cm 2 ).]]> Before use (D0) After use (D14) After use (D28) P-value Oil Control Reviews Example 1 0 -31.45 -42.56 0.001~0.01 efficient Example 2 0 -41.32 -57.62 0.001~0.01 efficient Example 3 0 -43.46 -58.77 <0.001 efficient Example 4 0 -44.25 -59.86 <0.001 efficient Comparative Example 1 0 -4.36 -6.22 >0.05 invalid Comparative Example 2 0 -4.31 -6.14 >0.05 invalid Comparative Example 3 0 -2.45 -3.17 >0.05 invalid Comparative Example 4 0 -3.67 -5.23 >0.05 invalid Comparative Example 5 0 -3.34 -5.43 >0.05 invalid Comparative Example 6 0 -2.64 -4.95 >0.05 invalid

[0100] The test results in Table 6 show that after 14 and 28 days of trial use, Examples 1, 2, 3, and 4 can significantly reduce oil secretion and are effective in oil control, indicating that the skin care products prepared by adding the composition with acne removal effect of the present invention can significantly and effectively produce an oil control effect. Comparative Examples 1-6 do not produce an oil control effect, indicating that the various components in the technical solution of the present invention work together to exert an oil control effect, and the oil control effect will be significantly reduced if any one of them is missing.

[0101] 4. Stability test

[0102] 4.1 Test conditions and methods The test results in Table 6 show that after 14 and 28 days of trial use, Examples 1, 2, 3, and 4 can significantly reduce oil secretion and are effective in oil control, indicating that the skin care products prepared by adding the composition with acne removal effect of the present invention can significantly and effectively produce an oil control effect. Comparative Examples 1-6 did not produce an oil control effect, indicating that the various components in the technical solution of the present invention work together to exert an oil control effect, and the lack of any one of them will significantly reduce the oil control effect.

[0103] Table 7. Stability test conditions and methods

[0104] Test conditions Test Method Room temperature (protected from light) Place the test sample at room temperature (avoid light) and observe the changes in the sample Cold resistant (5℃) The test samples were placed in a 5°C incubator for low temperature testing and the changes in the samples were observed. Cold resistance (-15℃) The test samples were placed in a -15℃ incubator for low temperature testing and the changes in the samples were observed. Heat resistant (45°C) The test samples were placed in a 45°C incubator for high temperature testing and the changes in the samples were observed. Light (North Light) Place the test sample under northern light and observe the changes in the sample Cold / heat cycling resistance The test samples were placed in a -15℃ / 45℃ high and low temperature alternating incubator for hot and cold cycle testing, with a cycle of 6 days, and the changes in the samples were observed

[0105] 4.2 Results and observations

[0106] The test results are shown in Table 8 (“√” indicates no abnormality).

[0107] Table 8. Stability test results

[0108] Group Light (North Light) Cold resistance (-15℃) Heat resistant (45°C) Hot and cold cycle Room temperature (protected from light) Cold resistant (5℃) in conclusion Example 1 √ √ √ √ √ √ Stablize Example 2 √ √ √ √ √ √ Stablize Example 3 √ √ √ √ √ √ Stablize Example 4 √ √ √ √ √ √ Stablize

[0109] It can be seen from Table 8 that the composition obtained by the technical solution of the present invention is very stable under various conditions.

[0110] 5. Security Testing

[0111] 5.1、Reference standard: SN / T2329-2009 In vitro eye irritation-chicken embryo chorioallantoic membrane test (HET-CAM method).

[0112] 5.2. In vitro eye irritation - chicken embryo chorioallantoic membrane test:

[0113] 5.2.1 Test materials

[0114] (1) Chicken embryo: SPF grade.

[0115] (2) Other materials: electronic timer.

[0116] (3) Experimental conditions: incubator temperature 37.5℃±0.5℃, relative humidity 50%-60%.

[0117] (4) Control: The negative control was 0.9% NaCl solution, and the positive control was 0.1 mol / L NaOH.

[0118] 5.2.2 Test steps

[0119] (1) CAM preparation: Purchase chicken embryos less than 7 days old and transport them to the laboratory with the air chamber facing upward. When the incubation reaches 9 days, use an egg candling device to check and discard defective chicken embryos. Mark the position of the air chamber on the eggshell surface of normal chicken embryos; use dental serrated curved forceps to remove the marked eggshell part to expose the white egg membrane; carefully use forceps to remove the inner membrane to ensure that the vascular membrane is not damaged.

[0120] (2) Preparation of test substances: The test substances were tested using the undiluted endpoint evaluation method; the positive and negative controls were tested using the same operating procedures.

[0121] (3) Formal test: For each group of 6 chicken embryos, 0.3 ml of the test substance was directly dripped onto the surface of the CAM. After 3 minutes, the reaction of the CAM was observed and the degree of reaction was recorded.

[0122] (4) Calculate the endpoint score (ES): score for each chicken embryo = the sum of the bleeding, coagulation and vascular melting observed in each chicken embryo; ES = the mathematical sum of the scores of 6 chicken embryos. Classify the eye irritation of the test substance according to the ES value.

[0123] 5.2.3 Results evaluation.

[0124] The eye irritation of the test substance is classified according to the calculated ES value:

[0125] Table 9. Classification criteria for eye irritation of test substances according to ES values

[0126] End point scoring Irritation classification ES≤12 No / mild irritation 12<ES<16 Moderate irritation ES≥16 Strong irritant / corrosive

[0127] 5.4 Experimental results:

[0128] The endpoint score ES value of the tested samples is as follows:

[0129] Table 10, Chicken embryo test results

[0130] Group Total score Rating (ES) Negative control 0 0 Positive Control 18 ≥16 Example 1 0.3 ES≤12 Example 2 0.2 ES≤12 Example 3 0.2 ES≤12 Example 4 0.4 ES≤12

[0131] From the test results in Table 10, it can be seen that the chicken embryo scores of Examples 1-4 are 0.3, 0.2, 0.2, and 0.4, respectively. According to the judgment standard of SN / T2329-2009, under the experimental conditions, the tested samples have no eye irritation and the samples have good safety.

[0132] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A composition having oil control and acne removal effects, characterized in that: The invention is composed of the following ingredients in parts by weight: 1-2 parts of salicylic acid, 0.01-0.2 parts of azelaic acid, 0.01-0.2 parts of succinic acid, 1-30 parts of oil palm extract, 1-30 parts of purple chrysanthemum extract, 1-30 parts of Potentilla root extract and 50-100 parts of deionized water.

2. The composition according to claim 1, characterized in that The invention is composed of the following ingredients in parts by weight: 1-1.5 parts of salicylic acid, 0.01-0.15 parts of azelaic acid, 0.01-0.15 parts of succinic acid, 1-20 parts of oil palm extract, 1-20 parts of purple chrysanthemum extract, 1-20 parts of Potentilla root extract and 50-80 parts of deionized water.

3. The composition according to claim 1, characterized in that The invention is composed of the following ingredients in parts by weight: 1 part of salicylic acid, 0.1 part of azelaic acid, 0.1 part of succinic acid, 15.5 parts of oil palm extract, 15.5 parts of chrysanthemum purpurogenum extract, 15.5 parts of Potentilla officinalis root extract and 75 parts of deionized water.

4. Use of a composition having oil control and acne removal effects as claimed in any one of claims 1 to 3 in the preparation of cosmetics, characterized in that: The composition is used in oil-controlling and acne-removing cosmetics.

5. The use according to claim 4, characterized in that: The oil-controlling and anti-acne cosmetic is a skin external preparation prepared by using the composition with oil-controlling and anti-acne effects as an active component and adding conventional pharmaceutical or cosmetic auxiliary materials or auxiliary ingredients.

6. The use according to claim 5, characterized in that: The added amount of the composition with oil-controlling and acne-removing effects in the oil-controlling and acne-removing cosmetic is 0.01-10%.

7. The use according to claim 5, characterized in that: The oil-controlling and anti-acne cosmetics are one or more of lotions, essences, creams, facial masks, and gels.

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