Antibacterial antiperspirant wet wipes and preparation method thereof

Abstract

This invention provides an antibacterial and antiperspirant wipe and its preparation method. The antibacterial and antiperspirant wipe comprises an antiperspirant liquid and a substrate carrying the antiperspirant liquid; the antiperspirant liquid includes the following components: an antiperspirant core-shell polymer, a humectant, a solvent, and a pH adjuster; wherein the shell material of the antiperspirant core-shell polymer is porous nano-silica, and the core material is a combination of green tea extract, mulberry leaf extract, and aluminum-based antiperspirant active ingredients. The antibacterial and antiperspirant wipe provided by this invention can directly wipe away surface sweat, reduce bacterial growth, and achieve a dry and deodorizing effect; the antiperspirant on the wipe remains on the skin surface, and the antiperspirant core-shell polymer can release active ingredients in response to the skin's pH, providing a long-lasting antiperspirant and antibacterial effect.

Description

Technical Field

[0001] The invention relates to the technical field of personal daily necessities, and in particular to an antibacterial and antiperspirant wet wipe and a preparation method thereof. Background Art

[0002] At present, there are various types of wet wipes on the market. Wet wipes have a wide range of uses, such as skin cleaning, kitchen cleaning, etc., which provide great convenience for people's daily life and gradually become an indispensable commodity in people's lives. Especially in recent years, with the improvement of people's quality of life and changes in living habits, the production and market of wet wipes have developed rapidly, and wet wipes products with diversified uses have gradually been developed.

[0003] Sweating is a natural physiological phenomenon. The human body takes away heat through sweating to regulate body temperature. In summer, the weather is hot. Sweat glands and sebaceous glands secrete a large amount of sweat, and the metabolism of lipid cells and blood sticky cells is out of balance. The organic matter contained in the secretion is decomposed by bacteria on the skin surface, mainly staphylococci, to produce excessive unsaturated fatty acids and produce specific odors, leading to blockage of the gland ducts, and the accumulation of sebum and lipids in the apocrine glands, which lose oxygen and mutate, and emit foul and sticky odors from the body through the pores of the cortex. It is easy to create some bad impressions on the human body: wet, sticky, sweat-stained clothes and body odor. What's more, the above problems caused by sweating can have a serious adverse effect on the self-confidence of some people. Therefore, in order to avoid the above problems, using wet wipes to wipe sweat has become a simple and common way in people's lives.

[0004] At present, the main method for wet wipes to remove odor is to wipe the area with contact, so as to reduce the amount of sweat in the armpits and prevent the sweat from being decomposed by bacteria to produce too many unsaturated fatty acids and produce specific odors, so as to achieve the purpose of antiperspirant and refreshing. At the same time, adding some fragrances or antibacterial agents to the wet wipes can also achieve the effect of antibacterial and body fragrance. This method is commonly used because of its simple operation, convenience and relatively low price. However, this method of directly wiping with wet wipes also has certain defects: for example, wet wipes can only be used after sweat is produced, and wiping the sweat on the body surface cannot prevent sweat production after using wet wipes.

[0005] Therefore, it is very important to develop a safe and non-toxic antiperspirant wipe that can be directly applied to the skin and can clean, stop sweating, and inhibit bacteria and body fragrance. Summary of the invention

[0006] Purpose of the invention: The purpose of the present invention is to provide an antibacterial antiperspirant wet wipe and a preparation method thereof, which can be used to clean the skin and wipe sweat, and at the same time play the role of antiperspirant, deodorant and antibacterial, is non-toxic, non-irritating and easy to use.

[0007] The technical solution of the present invention:

[0008] In one aspect, the present invention provides an antibacterial antiperspirant wet wipe, which is composed of an antiperspirant liquid and a substrate carrying the antiperspirant liquid; the antiperspirant liquid includes the following components: an antiperspirant core-shell polymer, a moisturizer, a solvent and a pH regulator; wherein the shell material of the antiperspirant core-shell polymer is porous nano-silica, and the core material is a combination of green tea extract, mulberry leaf extract and aluminum-based antiperspirant actives.

[0009] In some embodiments, based on the total mass of 100%, the mass percentages of the antiperspirant core-shell polymer, moisturizer, and pH adjuster are 10-30%, 1%-10%, and 0.5%-1%, respectively, and the remainder is solvent.

[0010] In some embodiments, the method for preparing the porous nano-silica includes: dispersing hexadecyltrimethylammonium bromide (CTAB) in an emulsion system solvent, stirring evenly, adding tetraethyl orthosilicate and aminopropyltrimethoxysilane dropwise into the above reaction system and stirring for reaction, then adding hydrochloric acid to terminate the reaction, collecting the product and placing it in a muffle furnace, and obtaining porous nano-silica after calcination.

[0011] In some embodiments, the emulsion system is a mixed system of water, anhydrous ethanol, cyclohexane and ammonia water, and the volume ratio of water, anhydrous ethanol, cyclohexane and ammonia water is 50-80:5-10:10-30:0.1-1.

[0012] In some embodiments, the added mass ratio of hexadecyltrimethylammonium bromide, ethyl orthosilicate and aminopropyltrimethoxysilane is 1:1-5:0.1-1.

[0013] In some embodiments, the green tea extract includes one or more combinations of green tea polyphenols, green tea caffeine, green tea essential oil, and green tea amino acids; preferably, the green tea extract refers to tea polyphenols, which have strong antioxidant and antibacterial properties and are convenient for use as an active ingredient in antiperspirants.

[0014] In some embodiments, the mulberry leaf extract includes one or more combinations of mulberry leaf quercetin, mulberry leaf chlorogenic acid, mulberry leaf alkaloids (1-deoxynojirimycin), and mulberry leaf amino acids (γ-aminobutyric acid); preferably, the mulberry leaf extract refers to mulberry leaf quercetin.

[0015] In some embodiments, the preparation method of the extract comprises: pretreating the raw material, using ethanol aqueous solution as an extraction solvent, mixing it with the raw material, and placing it in an extraction device for stirring and extraction. The extraction temperature is usually controlled at 40-50°C, and the extraction time is 1-2 hours. After the extraction is completed, the solid residue is filtered out, extracted with ethyl acetate, and then rotary evaporated to obtain an extract, which is then purified by column chromatography and dried to obtain an extract. When the raw material is mulberry leaf, a mulberry leaf extract is obtained; when the raw material is green tea, a green tea extract is obtained.

[0016] In some embodiments, the aluminum-based antiperspirant active is of the general formula Al2(OH) x Q y . Hydroxyl halides defined by wH2O, wherein Q represents chlorine, bromine or iodine, x is a variable from 2 to 5, and x+y=6, and wH2O represents a hydrate variable, such as aluminum chlorohydrate.

[0017] In some embodiments, the method for preparing the antiperspirant core-shell polymer comprises:

[0018] Step 1: adding a solution containing an aluminum-based antiperspirant active substance to a polybutylene succinate (PBS) solution containing a mulberry leaf extract and a green tea extract, and mixing them evenly to obtain an active substance solution;

[0019] Step 2: dissolving chitosan in a solvent, adding porous nano-silica into the solvent, uniformly dispersing by ultrasonication, and stirring for 24 hours to obtain modified porous nano-silica;

[0020] Step 3: Ultrasonic dispersion of the modified porous nano-silica in the active substance solution, and shaker treatment to obtain an antiperspirant core-shell polymer.

[0021] In some embodiments, the solvent of the solution containing the aluminum-based antiperspirant active is methanol or ethanol, and the concentration of the solution is 0.1-0.5 mol / L.

[0022] In some embodiments, in step 1, the weight ratio of the mulberry leaf extract, the green tea extract and the aluminum-based antiperspirant active is 2-5:1-2:1-3; preferably, the weight ratio of the mulberry leaf extract, the green tea extract and the aluminum-based antiperspirant active is 3-4:1:2-3.

[0023] In some embodiments, in step 2, the added mass ratio of chitosan to porous nano-silica is 1-1.5:1.

[0024] In some embodiments, the moisturizer is selected from one or more combinations of betaine, polyols, and natural moisturizing factors; wherein the polyol is selected from one or more combinations of 1,2-hexanediol, butanediol, glycerol, pentanediol, and caprylyl glycol. Preferably, the polyol is butanediol.

[0025] In some embodiments, the solvent is selected from, for example, C2-C4 straight or branched alkanols, such as ethanol and isopropanol, propanol, butanol; in particular, polyols having 2 to 20 carbon atoms, preferably 2 to 6 carbon atoms, such as glycerol, diglycerol, 1,3-propylene glycol, etc.; polyethylene glycols having 2 to 100 ethylene oxide units; and mixtures thereof.

[0026] In some embodiments, the pH adjuster is selected from one or more combinations of potassium citrate, disodium hydrogen phosphate, or sodium bicarbonate.

[0027] In another aspect, the present invention provides a method for preparing the above-mentioned antibacterial antiperspirant wet wipes, comprising:

[0028] Step 1: Prepare various components by mass percentage, mix and stir the various components to obtain an antiperspirant liquid;

[0029] Step 2: Soak the substrate in the antiperspirant liquid, seal it and let it stand for 3-6 hours, then take it out and aseptically package it to obtain the antibacterial antiperspirant wipes.

[0030] In some embodiments, the substrate is selected from one of nonwoven fabrics, fabrics, and natural fiber materials.

[0031] Beneficial effects:

[0032] The antibacterial antiperspirant wet wipes provided by the present invention can directly wipe off surface sweat, reduce bacterial reproduction, and achieve a drying and deodorizing effect; the antiperspirant on the wet wipes will remain on the skin surface, and the antiperspirant core-shell polymer can release active ingredients in response to pH, providing long-lasting antiperspirant and antibacterial effects.

[0033] The present invention extracts green tea extract and mulberry leaf extract from plants, both of which are natural essential oils, come from nature, are environmentally friendly, pollution-free, reliable, safe, and non-irritating. The natural plant extract and the aluminum-based antiperspirant active substance are used as composite effective ingredients, and the mulberry leaf extract and the green tea extract are matched with the aluminum-based antiperspirant active substance to synergistically improve the antiperspirant and antibacterial effects.

[0034] Human sweat is weakly acidic. Changes in pH can cause changes in the chitosan molecular chain structure on the polymer surface, exposing the carrier pores and releasing the antiperspirant active ingredients. The antiperspirant active ingredients are released when sweat appears on the body surface and are not released when there is no sweat on the body surface, thereby achieving a long-lasting antiperspirant effect. DETAILED DESCRIPTION

[0035] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0036] Unless otherwise specified, the chemical reagents used in the present invention are all commercially available analytically pure.

[0037] Preparation of mulberry leaf extract

[0038] Wash the fresh mulberry leaves and dry them at room temperature. Use a grinder to grind the dried mulberry leaves into fine powder. Use 70-80% (v / v) ethanol aqueous solution as the extraction solvent and mix it with mulberry leaf powder. The mixing volume ratio is mulberry leaf: extractant = 1:10. After mixing the mulberry leaf powder with the solvent, put it into the extraction device, control the extraction temperature at 40°C, extract for 2 hours, and stir to extract. After the extraction is completed, filter the solid residue, extract with ethyl acetate, and then rotary evaporate to obtain the extract, which is then purified by column chromatography and dried to obtain mulberry leaf extract.

[0039] Preparation of green tea extract

[0040] Wash the fresh green tea and dry it at room temperature. Use a grinder to grind the dried green tea into fine powder. Use 70-80% (v / v) ethanol aqueous solution as the extraction solvent and mix it with the green tea powder. The mixing volume ratio is green tea: extractant = 1:10. After mixing the green tea powder with the solvent, put it into the extraction device, control the extraction temperature to 40°C, extract for 2 hours, and stir to extract. After the extraction is completed, filter the solid residue, extract with ethyl acetate, and then rotary evaporate to obtain the extract, which is then purified by column chromatography and dried to obtain the green tea extract.

[0041] Preparation of porous nano-silica

[0042] Disperse 5 g of hexadecyltrimethylammonium bromide in 200 ml of an emulsion system solvent (the volume ratio of water: anhydrous ethanol: cyclohexane: ammonia water is 50:5:30:1), stir evenly, add 5 g of ethyl orthosilicate and 0.5 g of aminopropyltrimethoxysilane dropwise into the above reaction system and stir to react, then add 1 ml of hydrochloric acid (15%) to terminate the reaction, collect the product, wash it, place it in a muffle furnace, and calcine it at 550°C to obtain porous nano-silica.

[0043] Preparation of antiperspirant core-shell polymers

[0044] Step 1: adding an ethanol solution containing aluminum chlorohydrate to a polybutylene succinate solution containing a mulberry leaf extract and a green tea extract, and mixing them evenly to obtain an active substance solution;

[0045] Step 2: dissolving 15 g of chitosan in a solvent, adding 10 g of porous nano-silica into the solvent, uniformly dispersing by ultrasonication, and stirring for 24 hours to obtain modified porous nano-silica;

[0046] Step 3: Ultrasonic dispersion of the modified porous nano-silica in the active substance solution, and shaker treatment to obtain an antiperspirant core-shell polymer.

[0047] The addition amounts of the raw materials are shown in Table 1.

[0048] Table 1 Raw materials of different antiperspirant core-shell polymers

[0049] Weight(g) Mulberry Leaf Extract Green Tea Extract Aluminum Chlorohydrate Antiperspirant core-shell polymer 1 2 1 3 Antiperspirant core-shell polymer 2 5 2 3 Antiperspirant core-shell polymer 3 3 1 2 Antiperspirant core-shell polymer 4 6 0 0 Antiperspirant core-shell polymer 5 2 3 0

[0050] The supernatant of step 3 was collected and the aluminum chlorohydrate content was detected to be lower than the initial content, confirming that the active substance solution was successfully loaded on the porous nano-silica.

[0051] Example

[0052] Step 1: Prepare the components according to the mass percentages shown in Table 2, mix and stir the components to obtain an antiperspirant liquid;

[0053] Step 2: Soak the substrate non-woven fabric in the antiperspirant liquid, seal it and let it stand for 3 hours, then take it out and aseptically package it to obtain antibacterial antiperspirant wipes.

[0054] Table 2 Formula of each component of the embodiment

[0055] Embodiment (%, total mass fraction 100%) 1 2 3 4 5 Antiperspirant core-shell polymer 1 10 0 0 30 20 Antiperspirant core-shell polymer 2 0 10 0 0 0 Antiperspirant core-shell polymer 3 0 0 10 0 0 Humectant (Butylene Glycol) 1 1 1 10 6 pH adjuster (sodium bicarbonate) 0.5 0.5 0.5 1 0.5 Solvent (glycerol) margin margin margin margin margin

[0056] Comparative Example

[0057] Step 1: Prepare the components according to the mass percentages shown in Table 3, mix and stir the components to obtain an antiperspirant liquid;

[0058] Step 2: Soak the substrate non-woven fabric in the antiperspirant liquid, seal it and let it stand for 3 hours, then take it out and aseptically package it to obtain antibacterial antiperspirant wipes.

[0059] Table 3 Comparative Example Components

[0060] Comparative Example (%, total mass fraction 100%) 1 2 3 4 5 Porous Nano-Silica 0 10 0 0 0 Active substance solution 0 0 10 0 0 Antiperspirant core-shell polymer 4 0 0 0 10 0 Antiperspirant core-shell polymer 5 0 0 0 0 10 Humectant (Butylene Glycol) 1 1 1 1 1 pH adjuster (sodium bicarbonate) 0.5 0.5 0.5 0.5 0.5 Solvent (glycerol) margin margin margin margin margin

[0061] The antibacterial antiperspirant wipes obtained above were tested as follows:

[0062] 1. Antibacterial test: Use a pipette to take 5 mL of a 10 5CFU / mL of Staphylococcus aureus suspension and Candida albicans were respectively dripped into 2mL of the antiperspirant obtained in the embodiment and the comparative example as the experimental group; 2mL was then dripped into 2mL of normal saline as the control blank group, introduced into the nutrient agar medium, the pH was adjusted to the optimal pH for strain growth, and evenly coated with a sterile triangular rod. The medium was ventilated and dried for 15 minutes, and a sterile filter paper with a diameter of about 5 mm was placed in the center of the plate medium. The plate was cultured at 37°C for 24 hours, and the number of colonies was determined according to the plate count method. Three parallel tests were performed for each sample, and the counting results were averaged to calculate the inhibition rate.

[0063] 2. Antiperspirant test: 30 volunteers were selected as subjects, half of them were male and half were female, and the antibacterial antiperspirant wipes of each embodiment and comparative example were used to wipe the armpits back and forth once each. Afterwards, a fiber pad was placed in the armpit area of ​​the subject as an absorbent pad to absorb sweat. After 90 minutes, the amount of sweat absorbed by the absorbent pad was obtained. At the same time, a group of unwiped tests were conducted as a blank control. Then, the reduction rate of sweat discharge before and after the subjects used the antibacterial antiperspirant wipes was calculated to analyze the effect of the antibacterial antiperspirant wipes in reducing sweat secretion. The antiperspirant test was conducted in an environment with a temperature of (37.8±1.1)℃ and a relative humidity of 35%-40%.

[0064] 3. Long-term test: The 30 volunteers who participated in the antiperspirant test continued to participate in the long-term test experiment. After wiping the armpits with the antibacterial antiperspirant wipes of each embodiment and comparative example once, the test subjects evaluated the armpit body feeling (refreshing, slightly sticky, sticky) by themselves 4 hours later, and the one with the most evaluation was taken as the evaluation result of the current target product to detect the long-term effect of the wipes.

[0065] The test results are shown in Table 4.

[0066] Table 4 Test results of test 1 and test 2

[0067]

[0068] It can be seen from the test data provided by the embodiment and the comparative example that the antibacterial rate, antiperspirant rate and antiperspirant time of the antibacterial antiperspirant wipes prepared in the embodiment are better than those in the comparative example. This is because the antiperspirant core-shell polymer is used in the embodiment, and the shell material of the polymer is porous nano-silica. After the porous nano-silica is modified with chitosan, it can release the core material according to the pH value of the body surface, and play a long-term antiperspirant and antibacterial effect; and the core material is composed of green tea extract, mulberry leaf extract and aluminum-based antiperspirant actives. After being used in combination, it can synergistically enhance the antiperspirant effect of the aluminum-based antiperspirant active and the antibacterial effect of natural fragrances, which has technological progress.

[0069] From the comparison of the embodiments, it can be seen that the ratio of green tea extract, mulberry leaf extract and aluminum-based antiperspirant active in Example 3 is 3:1:2. Compared with Examples 1 and 2, it can be obtained that the antiperspirant core-shell polymer at this ratio has a more excellent antiperspirant effect and antibacterial effect, and has a synergistic effect.

[0070] The present invention can also have many other embodiments. Without departing from the spirit and essence of the present invention, those skilled in the art can make various corresponding changes and modifications based on the present invention, but these corresponding changes and modifications should all fall within the scope of protection of the claims attached to the present invention.

Claims

1. An antibacterial antiperspirant wet wipe, comprising an antiperspirant liquid and a substrate carrying the antiperspirant liquid; characterized in that: The antiperspirant liquid comprises the following components: an antiperspirant core-shell polymer, a moisturizer, a solvent and a pH regulator; wherein the shell material of the antiperspirant core-shell polymer is porous nano-silicon dioxide, and the core material is a combination of green tea extract, mulberry leaf extract and aluminum-based antiperspirant active substances.

2. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: Based on the total mass of 100%, the mass percentages of the antiperspirant core-shell polymer, moisturizer and pH regulator are 10-30%, 1%-10% and 0.5%-1% respectively, and the remainder is solvent.

3. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: The preparation method of the porous nano-silica comprises: dispersing hexadecyltrimethylammonium bromide in an emulsion system solvent, uniformly stirring, adding ethyl orthosilicate and aminopropyltrimethoxysilane dropwise into the reaction system, stirring for reaction, adding hydrochloric acid to terminate the reaction, collecting the product and placing it in a muffle furnace, and burning to obtain the porous nano-silica.

4. The antibacterial antiperspirant wet wipes according to claim 3, characterized in that: The added mass ratio of hexadecyltrimethylammonium bromide, ethyl orthosilicate and aminopropyltrimethoxysilane is 1:1-5:0.1-1.

5. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: The preparation method of the extract comprises: pre-treating raw materials, using ethanol water solution as an extraction solvent, mixing the ethanol water solution with the raw materials, and putting the ethanol water solution into an extraction device for stirring and extraction.

6. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: Aluminum-based antiperspirant active ingredients are composed of the general formula Al2(OH) x Q y . Hydroxyl halides defined by wH2O; wherein Q represents chlorine, bromine or iodine, x is a variable from 2 to 5, and x+y=6, and wH2O represents a hydrated variable.

7. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: The preparation method of the antiperspirant core-shell polymer comprises: Step 1: adding a solution containing an aluminum-based antiperspirant active substance to a polybutylene succinate solution containing a mulberry leaf extract and a green tea extract, and mixing them evenly to obtain an active substance solution; Step 2: dissolving chitosan in a solvent, adding porous nano-silica into the solvent, uniformly dispersing by ultrasonication, and stirring for 24 hours to obtain modified porous nano-silica; Step 3: Ultrasonic dispersion of the modified porous nano-silica in the active substance solution, and shaker treatment to obtain an antiperspirant core-shell polymer.

8. The antibacterial antiperspirant wet wipes according to claim 7, characterized in that: In step 1, the weight ratio of the mulberry leaf extract, the green tea extract and the aluminum-based antiperspirant active is 2-5:1-2:1-3; in step 2, the added mass ratio of the chitosan and the porous nano-silicon dioxide is 1-1.5:

1.

9. The antibacterial antiperspirant wet wipes according to claim 1, characterized in that: The moisturizer is selected from one or more combinations of betaine, polyol, and natural moisturizing factor; the solvent is selected from one or more combinations of C2-C4 straight-chain or branched alkanols; and the pH adjuster is selected from one or more combinations of potassium citrate, disodium hydrogen phosphate, or sodium bicarbonate.

10. The method for preparing the antibacterial antiperspirant wet wipes according to any one of claims 1 to 9, characterized in that: include: Step 1: Prepare various components by mass percentage, mix and stir the various components to obtain an antiperspirant liquid; Step 2: Soak the substrate in the antiperspirant liquid, seal it and let it stand for 3-6 hours, then take it out and aseptically package it to obtain the antibacterial antiperspirant wipes.

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