Acne-removing composition particles based on natural plant extracts and preparation method thereof

Abstract

The invention discloses an anti-acne composition particle based on natural plant extracts and a preparation method thereof, and relates to the technical field of daily chemical products. The anti-inflammatory, anti-acne and oil-control composition prepared from extracts of natural plants such as liquorice, salvia miltiorrhiza and scutellaria baicalensis has the effects of antibacterial, regulating oil secretion and anti-inflammatory and soothing, can effectively prevent and treat acne, and has remarkable effects of removing acne and regulating oil secretion. At the same time, the composition does not contain hormones and antibiotics, has no toxic side effects, has mild effects and is non-irritating to the skin. The composition improves the solubility of the natural plant extract through granulation technology, ensures the stability of the composition ratio, and enhances the synergistic effect of the natural plant extract, so that the ability of the natural plant extract to inhibit Propionibacterium acnes, cure acne and regulate skin oil secretion is sustained and effective. The composition can be used to treat acne caused by various reasons, and is applied to cosmetics and skin care products, which is milder to the human body, safe and non-irritating, suitable for sensitive skin, and suitable for use by people of all ages.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, and in particular to acne-removing composition particles based on natural plant extracts and a preparation method thereof. Background Art

[0002] With the accelerated pace of life and the increasing pressure of work and life, coupled with frequent environmental pollution and food safety problems, the incidence of acne has been increasing year by year.

[0003] Acne is the common name for acne, a common chronic inflammatory disease of the hair follicles and sebaceous glands. It is prone to occur in areas with strong sebum secretion such as the face, chest and upper back. It has a long course and is prone to recurrence. It often manifests as whiteheads, blackheads or inflammatory papules. In severe cases, there will be pustules, nodules, cysts or scars. If the inflammation is obvious, it will cause pain or tenderness, accompanied by sebum overflow, and even orange peel face.

[0004] Studies have shown that the pathogenesis of acne is mainly related to androgens, increased sebum secretion, hyperkeratinization of hair follicles, proliferation of Propionibacterium acnes, and genetic factors. Propionibacterium acnes plays an important role in the pathogenesis of acne. It is one of the important pathogens of acne and an important target for topical drugs to treat acne. The lipase it produces breaks down sebum to produce free fatty acids, while chemotacticizing inflammatory cells and mediators, ultimately inducing and aggravating inflammatory responses.

[0005] At present, most products on the market shrink pores to reduce excessive oil on the skin surface, thereby improving the effect of a shiny face. However, for skin with excessive sebum secretion, it is more likely to cause pore blockage, inflammation and acne. The most common cosmetics for treating acne are to add chemical fungicides, hormones, astringents and anti-inflammatory agents. Although they can kill bacteria or reduce inflammation in a short period of time, they are very irritating to the skin. Long-term use will increase the burden on the skin and cause allergic symptoms such as skin redness, suppuration or pain. In addition, because pathogens are very easy to develop drug resistance, acne will soon recur and form scars or pigmentation.

[0006] Therefore, plant antibacterial agents are used to control the growth and reproduction of inflammatory microorganisms in hair follicles. At the same time, natural plant ingredients are used to regulate the metabolic balance of the skin and solve the problem of excessive oil secretion of the skin from the root. This is both safe and can thoroughly improve the health of the skin, thereby achieving a rapid cure for acne. Summary of the invention

[0007] In order to overcome the deficiencies in the background technology, the present invention provides an acne-removing composition particle based on natural plant extracts and a preparation method thereof. The present invention can make up for the deficiencies of existing acne treatment products in terms of efficacy and / or overall quality. The natural plant active ingredient composition particles are stable in nature. When added to cosmetics, in addition to having significant effects on treating acne and acne scars, they also have the effects of regulating oil secretion and anti-inflammatory and soothing, and can effectively prevent and treat acne, etc.

[0008] In order to achieve the above-mentioned purpose of the invention, the present invention adopts the following technical solution: An anti-acne composition particle based on natural plant extracts, the anti-acne composition particle comprises the following components in percentage by weight: Licorice extract 60-65%; Salvia miltiorrhiza extract 15-20%; Scutellaria baicalensis extract 5-10%; Cymene 10-15%.

[0009] In the acne-removing composition particles based on natural plant extracts, the licorice extract is a flavonoid or triterpenoid compound.

[0010] In the acne-removing composition particles based on natural plant extracts, the salvia miltiorrhiza extract is tanshinone or salvianolic acid.

[0011] In the acne-removing composition particles based on natural plant extracts, the scutellaria baicalensis extract is baicalin or baicalein.

[0012] A method for preparing acne-removing composition particles based on natural plant extracts, the preparation method specifically comprising the following steps: The first step is to put the liquorice extract, the salvia miltiorrhiza extract and the scutellaria baicalensis extract into an oven and place them at 40 to 60° C. for 20 to 36 hours until the extracts are completely dried; Step 2: Weigh liquorice extract, salvia miltiorrhiza extract, scutellaria baicalensis water extract and cymene according to a preset ratio, put them into a grinder, grind them for 8 to 15 minutes, and pass them through a 60 to 100 mesh sieve to obtain a composite powder after they are completely ground; Step 3: Put the sieved composition powder into a mixer and mix for 0.5 to 1.5 hours to obtain a dry powder containing a natural plant extract composition; Step 4: put the dry powder into a granulator to obtain natural plant anti-acne composition particles.

[0013] By adopting the above technical solution, the present invention has the following advantages: The anti-inflammatory, acne-removing and oil-controlling composition of the present invention is made from extracts of natural plants such as liquorice, salvia miltiorrhiza and scutellaria baicalensis, and has antibacterial, oil secretion regulating and anti-inflammatory and soothing effects, can effectively prevent and treat acne, and has significant effects of acne removal and oil secretion regulating. At the same time, it does not contain hormones and antibiotics, has no toxic side effects, has a mild effect, and is non-irritating to the skin. The present invention improves the solubility of natural plant extracts through granulation technology, ensures the stability of the composition ratio, and enhances the synergistic effect of natural plant extracts, so that the ability to inhibit acne bacteria, cure acne and regulate skin oil secretion is sustained and effective; The present invention can be used to treat acne caused by various reasons, and can be applied to cosmetics and skin care products, such as gels, creams, facial masks, facial cleansers, etc. It is gentler to the human body, safer and non-irritating, suitable for sensitive skin, and suitable for use by people of all ages. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 is the inhibition rate of the acne-removing composition particles on Propionibacterium acnes in a specific embodiment of the present invention; Figure 2 This is the effect of the anti-acne composition particles on the amount of skin oil secretion in a specific embodiment of the present invention. DETAILED DESCRIPTION

[0015] The present invention can be explained in more detail by the following examples, but the present invention is not limited to the following examples; Combined with Figures 1-2 The acne-removing composition particles based on natural plant extracts of the present invention include the following components in terms of weight percentage: Licorice extract 60-65%; Salvia miltiorrhiza extract 15-20%; Scutellaria baicalensis extract 5-10%; Cymene 10-15%; During implementation, the licorice extract, salvia miltiorrhiza extract, scutellaria baicalensis extract and cymene are active ingredients of the composition.

[0016] Cymene has significant inhibitory and killing effects on bacteria, fungi, yeasts, and molds. It can inhibit the proliferation of Propionibacterium acnes, resist irritation, and resist sebum leakage. At the same time, it can increase skin moisturizing, improve skin texture, and reduce fine lines and other problems. It combines with water molecules on the skin surface to form a protective film, locks in moisture in the skin, and prevents moisture loss. When used in cosmetics, it has good stability and can maintain long-term effects.

[0017] In specific practice, the licorice extract is a flavonoid or triterpenoid compound.

[0018] During implementation, licorice extract is derived from licorice, contains flavonoids and triterpenoids, has good stability, is safe and non-toxic. Among them, triterpenoids have anti-inflammatory, anti-ulcer, antioxidant, antibacterial, and effective cleaning effects of superoxide ions and hydroxyl radicals. Flavonoids have a cooling and refreshing effect, can relieve the inflammatory response of the skin, reduce skin allergy symptoms, and can also shrink pores to make the skin more delicate. Therefore, licorice extract is widely used in skin creams, shower gels, freckle creams, facial masks, etc. in the cosmetics industry.

[0019] Furthermore, the Salvia miltiorrhiza extract is tanshinone or salvianolic acid.

[0020] During implementation, Danshen extract mainly contains tanshinone and salvianolic acid, which are the main active substances of the natural plant Danshen and are also the most suitable ingredients for use in the cosmetics field. Tanshinone and salvianolic acid have the effects of promoting blood circulation and removing blood stasis, resisting lipid peroxidation and scavenging free radicals, improving microcirculation, and anti-aging. Tanshinone has significant effects in antibacterial and anti-inflammatory, treating acne and enhancing metabolism. In addition, Danshen extract has good safety and tolerability in the actual application of cosmetic formulas, and is a natural acne-removing and anti-inflammatory active ingredient.

[0021] Furthermore, the scutellaria baicalensis extract is baicalin or baicalein.

[0022] In practice, the scutellaria extract is an effective ingredient extracted from scutellaria, retaining the active ingredients in scutellaria, such as baicalin and baicalein, and is commonly used in traditional Chinese medicine, health products, cosmetics and other fields. Baicalin and baicalein are both flavonoids, with multiple biological activities such as antioxidant, anti-inflammatory, antibacterial, antiviral, and anti-tumor. In addition, baicalin can also be used for skin care, whitening, weight loss and other aspects. Studies have shown that baicalein can promote the regeneration and repair of skin cells and improve skin pigmentation, spots and other problems.

[0023] A method for preparing acne-removing composition particles based on natural plant extracts, the preparation method specifically comprising the following steps: The first step is to put the liquorice extract, the salvia miltiorrhiza extract and the scutellaria baicalensis extract into an oven and place them at 40 to 60° C. for 20 to 36 hours until the extracts are completely dried; Step 2: Weigh liquorice extract, salvia miltiorrhiza extract, scutellaria baicalensis water extract and cymene according to a preset ratio, put them into a grinder, grind them for 8 to 15 minutes, and pass them through a 60 to 100 mesh sieve to obtain a composite powder after they are completely ground; Step 3: Put the sieved composition powder into a mixer and mix for 0.5 to 1.5 hours to obtain a dry powder containing a natural plant extract composition; Step 4: put the dry powder into a granulator to obtain natural plant anti-acne composition particles.

[0024] In specific practice, the anti-acne composition particles prepared by the present invention are added to polyols for dissolution, and cosmetic excipients are added at the same time, and can be applied to anti-inflammatory and anti-acne cosmetics and skin care products.

[0025] The commonly used cosmetic auxiliary materials are one or more of surfactants, emulsifiers, thickeners, humectants, preservatives, emollients, pH regulators and fragrances.

[0026] During implementation, the surfactant is selected from at least two of coconut acid monoethanolamide, coconut acid diethanolamide, monolauryl phosphate, and disodium lauryl iminodiacetate.

[0027] The emulsifier is selected from one or two of cetearyl glucoside, PEG-100 stearate, and cetearyl alcohol.

[0028] The thickener is selected from one or two of carbomer, hydroxyethyl cellulose, xanthan gum, sodium alginate, and ammonium acryloyldimethyltaurate.

[0029] The moisturizing agent is selected from at least one of propylene glycol, butylene glycol, allantoin, polyglutamic acid and glycerin.

[0030] The preservative is selected from at least two of benzyl alcohol, methylchloroisothiazolinone, methylisothiazolinone and p-hydroxyacetophenone.

[0031] The emollient is selected from at least one of jojoba oil, cyclopolydimethylsiloxane, polydimethylsiloxane, and glyceryl stearate.

[0032] The pH regulator is selected from aminomethyl propanol and triethanolamine.

[0033] The fragrance is selected from any one of essence and essential oil.

[0034] In the specific implementation of the present invention, the salvia miltiorrhiza extract, the liquorice extract and the scutellaria baicalensis extract are prepared by using existing technical equipment, and other cosmetic auxiliary materials are all commercially available products.

[0035] The specific application examples of the present invention are as follows: Example 1: Dry powder particles containing the natural plant extract composition of the present invention Example 1 The dry powder particles containing the natural plant extract composition of the present invention include the following preparation raw materials by mass percentage:

[0036] Preparation method: S1: Place the plant extract in an oven at 40°C for 20 hours until the extract is completely dried; S2: Put the Danshen extract, Licorice extract, Scutellaria baicalensis extract and cymene into a grinder in a ratio of 18:60:8:14, grind for 8 minutes, and pass through a 60-mesh sieve after being completely ground; S3: putting the sieved powder into a mixer and mixing for 0.5 h to obtain a dry powder containing a natural plant extract composition; S4: putting the dry powder into a granulator to obtain natural plant anti-acne composition particles; Example 2: Gel containing the natural plant extract composition of the present invention Example 2 The gel containing the natural plant extract composition of the present invention comprises the following preparation raw materials by mass percentage:

[0037] Preparation method: S1: Place the plant extract in an oven at 50°C for 24 hours until the extract is completely dried; S2: Put the Danshen extract, Licorice extract, Scutellaria baicalensis extract and cymene into a grinder in a ratio of 16:65:7:12, grind for 10 minutes, and pass through an 80-mesh sieve after being completely ground; S3: putting the sieved powder into a mixer and mixing for 1 hour to obtain a dry powder containing a natural plant extract composition; S4: putting the dry powder into a granulator to obtain natural plant anti-acne composition particles C; Add water to phase A to disperse and swell. After swelling is complete, add it together with phase B into the emulsifying pot, heat and stir at 85℃ to completely dissolve, keep warm for 20 minutes, then defoam and cool down; Add water to phase D to dissolve, and when the temperature drops to 45°C, add the mixture of phases A and B into phase D and stir evenly to obtain a mixed solution; When the temperature drops to about 37°C, add phase C to the mixed solution in S6 and stir evenly. Add phase E and mix evenly. After the mixture is aligned and qualified, discharge the mixture to obtain a gel containing the natural plant extract composition of the present invention.

[0038] Example 3: Facial mask containing the natural plant extract composition of the present invention Example 3 The facial mask containing the natural plant extract composition of the present invention comprises the following raw materials by mass percentage:

[0039] Preparation method: S1: Place the plant extract in an oven at 60°C for 36 hours until the extract is completely dried; S2: Put the Danshen extract, Licorice extract, Scutellaria baicalensis extract and cymene into a grinder in a ratio of 18:62:8:12, grind for 15 minutes, and pass through a 100-mesh sieve after being completely ground; S3: putting the sieved powder into a mixer and mixing for 1.5 hours to obtain a dry powder containing a natural plant extract composition; S4: putting the dry powder into a granulator to obtain natural plant anti-acne composition particles C; Put phase A into a homogenizer, heat to 85℃ and homogenize for 5 minutes to make it completely dissolved; add phase B into phase A, stir and dissolve, keep warm for 30 minutes and then start to cool down; When the temperature drops to about 40°C, add phase C and stir evenly; When the temperature drops to about 35°C, add phase D, stir evenly, and discharge the material after it passes the plate alignment to obtain a facial mask liquid containing the natural plant extract composition of the present invention; The facial mask paper is soaked in the facial mask liquid described in S7 to prepare a facial mask containing the natural plant extract composition of the present invention.

[0040] Example 4: Anti-acne cream containing the natural plant extract composition of the present invention Example 4 The anti-acne cream containing the natural plant extract composition of the present invention comprises the following preparation raw materials by mass percentage:

[0041] Preparation method: S1: Place the plant extract in an oven at 50°C for 24 hours until the extract is completely dried; S2: Put the Danshen extract, Licorice extract, Scutellaria baicalensis extract and cymene into a grinder in a ratio of 15:64:10:11, grind for 10 minutes, and pass through an 80-mesh sieve after being completely ground; S3: putting the sieved powder into a mixer and mixing for 1 hour to obtain a dry powder containing a natural plant extract composition; S4: putting the dry powder into a granulator to obtain natural plant anti-acne composition particles; Dissolving the anti-acne composition particles in butylene glycol to obtain C; Heat phase A and phase B to 85°C respectively to completely dissolve them and keep warm for 30 minutes; Add phase B to phase A and stir thoroughly to make it uniform; When the temperature drops to about 65°C, add B2 and keep warm for 30 minutes; When the temperature drops to about 45° C., add item C and phase D and stir evenly to obtain the anti-acne cream containing the natural plant extract composition of the present invention.

[0042] Comparative Examples 1 to 4 are as follows: The anti-acne creams of Comparative Examples 1 to 4 include the following raw materials by mass percentage:

[0043] The preparation method is similar to that of Example 4.

[0044] The gels of Comparative Examples 5 to 8 include the following raw materials, calculated by mass percentage:

[0045] The preparation method is similar to that of Example 2.

[0046] Test Example 1: The antibacterial performance of cosmetics containing the natural plant extract of the present invention against Propionibacterium acnes is tested as follows: 1. Main equipment and reagents: (1) Biological safety cabinet and biochemical incubator; (2) Clostridium enrichment medium, phosphate buffered saline (PBS); (3) Standard strain: Propionibacterium acnes ATCC6919; 2. Test methods: (1) Inspection process: ① Dilute the test bacterial solution appropriately with PBS solution. The required concentration is: take 0.1mL and drop it into 5.0mL of control sample solution (PBS). The number of recovered bacteria is 1×104~9×104 CFU / mL; ② Dilute the test sample with sterile standard hard water to the specified concentration; ③Pipette 5mL of the original sample solution or its dilution into a sterile test tube, pipette 0.1mL of the above test bacterial solution into the test tube containing 5mL of the sample, mix quickly, and start timing immediately; ④ After 20 minutes of action, take 0.5 mL of the above mixture and add it into a test tube containing 4.5 mL of sterilized PBS and mix thoroughly; ⑤ After 10 minutes, take 1 mL of the sample solution and place it in a sterile plate. Inoculate two sterile plates for each sample solution or dilution. ⑥ Pour 15 mL of Clostridium enrichment medium cooled to 40℃~45℃ into the plate, rotate the plate to mix it thoroughly, turn the plate over after the medium solidifies, and incubate it anaerobically in a 37℃ constant temperature incubator for 72 hours, then count the viable colonies; ⑦Substitute PBS for the test sample and follow the above steps as a blank control group. Repeat the experiment 3 times and calculate the average value; ⑧The test needs to configure a negative control group (bacterial suspension, culture medium, sterile standard hard water).

[0047] 3. Calculation of results: Antibacterial rate (%) = (AB) / A×100%; Where: A represents the average colony count of the blank control sample; B represents the average colony count of the test group.

[0048] 4. Test results: from Figure 1 The results show that the composition of the present invention has a significant antibacterial effect on Propionibacterium acnes, among which Example 4 and Example 2 have the highest inhibition rates on Propionibacterium acnes, reaching 99.75% and 99.91% respectively. It can also be seen that the composition has a significant effect of inhibiting Propionibacterium acnes.

[0049] Test Example 2: Test on the effect of cosmetics containing natural plant extracts of the present invention on reducing oil secretion 1. Main equipment and reagents: (1) Grease measuring instrument; (2) Cosmetic products of Example 2, Example 4, and Comparative Examples 1-8; 2. Test methods: 50 volunteers with no history of cosmetic allergies and oily or mixed skin, aged between 20 and 50 years old, were selected to use the product for 1 week. The oil content on the skin surface was measured with an oil meter. The product was discontinued and the oil content on the skin surface was measured again after 21 days. The reduction in the skin's lasting oil secretion was calculated and the average value was taken. The test evaluation results are shown in Figure 2 .

[0050] 3. Test results: The test shows that after using the product for one week, Examples 2 and 4 and Comparative Examples 2 to 8 all have the effect of continuously regulating the reduction of oil secretion, especially Example 2 and Example 4 have the most ideal effect. Therefore, the present invention can regulate the ability of skin oil secretion from the root.

[0051] Test Example 3: Test on the anti-acne effect of cosmetics containing the natural plant extract of the present invention 1. Main equipment and reagents: Example 2, Example 4, Comparative Examples 1 to 8 cosmetic products; 2. Test methods: 132 volunteers with no cosmetic allergy and diagnosed with mild and mild to moderate acne were selected and divided into 11 groups, with 12 people in each group, aged between 20 and 50 years old, and used the product for 4 consecutive weeks. The detailed results are shown in Table 1.

[0052] The treatment standards are as follows: Recovery: The skin lesions disappear, or only a small amount of pigmentation remains, and the symptoms disappear.

[0053] Markedly effective: Most of the skin lesions disappeared and the symptoms were significantly alleviated.

[0054] Effective: Skin lesions partially subsided and symptoms improved.

[0055] Ineffective: The skin lesions did not disappear significantly and the symptoms did not improve.

[0056] 3. Test results: Table 1 Anti-acne effect of natural plant extract composition

[0057] Comparative Example 1, Comparative Example 5 and the negative control group are cosmetic bases without natural plant extracts. The test results show that after continuous use of the products for 4 weeks, Examples 2 and 4 and Comparative Examples 2, 3, 4, 6, 7, 8 all have the effect of continuously regulating the reduction of oil secretion, especially Example 2 and Example 4 have the most ideal effect, the acne removal effect reaches 91.7%, and the cure rate reaches 58.3% and 50.0%, respectively. Therefore, the present invention has a significant acne removal effect, and after long-term use, it can achieve the effect of fading acne marks and inhibiting acne growth.

[0058] The beneficial effects of the present invention are as follows: (1) The product of the present invention is an anti-inflammatory, acne-removing and oil-controlling composition made from extracts of natural plants such as licorice, salvia miltiorrhiza and scutellaria baicalensis. It has antibacterial, oil secretion regulating and anti-inflammatory and soothing effects, can effectively prevent and treat acne, and has significant effects in removing acne and regulating oil secretion. At the same time, it does not contain hormones and antibiotics, has no toxic side effects, has a mild effect, and is non-irritating to the skin.

[0059] (2) The present invention improves the solubility of natural plant extracts through granulation technology, ensures the stability of the composition ratio, and enhances the synergistic effect of natural plant extracts, so that their ability to inhibit Propionibacterium acnes, cure acne and regulate skin oil secretion is sustained and effective.

[0060] (3) The product of the present invention can be used to treat acne caused by various reasons. It can be applied to cosmetics and skin care products, such as gels, creams, facial masks, facial cleansers, etc. It is gentler on the human body, safer and non-irritating, suitable for sensitive skin, and suitable for people of all ages.

[0061] Parts of the present invention not described in detail are prior art.

[0062] The embodiments selected herein for the purpose of disclosing the invention are currently considered to be suitable, but it should be understood that the invention is intended to include all changes and modifications of the embodiments that fall within the scope of the concept and invention.

Claims

1. An anti-acne composition particle based on natural plant extracts, characterized by: The acne-removing composition particles include the following components by weight percentage: Licorice extract 60-65%; Salvia miltiorrhiza extract 15-20%; Scutellaria baicalensis extract 5-10%; Cymene 10-15%.

2. The acne-removing composition particles based on natural plant extracts according to claim 1, characterized in that: The licorice extract is a flavonoid or triterpenoid compound.

3. The acne-removing composition particles based on natural plant extracts according to claim 1, characterized in that: The salvia miltiorrhiza extract is tanshinone or salvianolic acid.

4. The acne-removing composition particles based on natural plant extracts according to claim 1, characterized in that: The scutellaria baicalensis extract is baicalin or baicalein.

5. The method for preparing the anti-acne composition particles based on natural plant extracts according to any one of claims 1 to 4, characterized in that: The preparation method specifically comprises the following steps: The first step is to put the liquorice extract, the salvia miltiorrhiza extract and the scutellaria baicalensis extract into an oven and place them at 40 to 60° C. for 20 to 36 hours until the extracts are completely dried; Step 2: Weigh liquorice extract, salvia miltiorrhiza extract, scutellaria baicalensis water extract and cymene according to a preset ratio, put them into a grinder, grind them for 8 to 15 minutes, and pass them through a 60 to 100 mesh sieve to obtain a composite powder after they are completely ground; Step 3: Put the sieved composition powder into a mixer and mix for 0.5 to 1.5 hours to obtain a dry powder containing a natural plant extract composition; Step 4: put the dry powder into a granulator to obtain natural plant anti-acne composition particles.

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