Composition for comprehensive maintenance of joints and preparation method thereof

Abstract

The invention provides a composition for comprehensive maintenance of joints and a preparation method thereof.The composition is prepared from, by weight, 20-50 parts of an eggshell membrane extract, 5-15 parts of a joint supplement and 5-15 parts of a cartilage anti-inflammatory component, the eggshell membrane extract, the frankincense extract, the cartilage repair component, the joint supplement and the cartilage anti-inflammatory component are mixed, and the cartilage anti-inflammatory component is prepared from, by weight, 20-50 parts of the cartilage repair component, 5-15 parts of the joint supplement and 5-15 parts of the eggshell membrane extract. The cartilage anti-inflammatory component accounts for 1-10 parts, the eggshell membrane extract accounts for 10-30 parts, and the frankincense extract accounts for 1-10 parts. Functional components such as a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component and natural components such as a frankincense extract and an eggshell membrane extract are combined, the limitation of a single-component supplement is overcome, comprehensive treatment of anti-inflammatory, repair and lubrication is provided, and the joint repairing and lubricating composition has relatively high biocompatibility, can be more easily acted on a joint part, and can be applied to the joint part. Through the synergistic effect of multiple mechanisms, the joint function is improved, inflammation is relieved, and cartilage repair and protection are promoted.

Description

Technical Field

[0001] The present invention belongs to the technical field of joint care, and in particular relates to a composition for comprehensive joint care and a preparation method thereof. Background Art

[0002] Osteoarthritis (OA) is one of the most common forms of joint disease, which causes the breakdown of joint cushioning substances and cartilage, causing bones to rub against each other, resulting in stiffness, pain, and loss of joint movement. In the related art, synthetic nutritional supplements are used to improve osteoarthritis, but many synthetic supplements have a low absorption rate after oral administration, and the proportion that enters the joints to take effect is limited. Most nutritional supplements need to be taken for a long time to be effective, and are not suitable for patients who need quick relief of pain and inflammation. A single ingredient cannot fully solve the multiple pathological problems of joint degeneration, and some synthetic supplements cause gastrointestinal discomfort, allergic reactions, or interact with other drugs.

[0003] In summary, the above ingredients all have poor biocompatibility, are difficult to fully enter the joints to exert their effects, and have side effects such as allergic reactions. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a composition for comprehensive joint care and a preparation method thereof, aiming to solve the problems of large side effects and poor biocompatibility of the joint care composition.

[0005] To solve the above problems, the present invention provides a composition for comprehensive joint care, the composition comprising an eggshell membrane extract, an frankincense extract, a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component. In terms of weight, in the powder of the composition, the cartilage repair component accounts for 20 to 50 parts, the joint supplement accounts for 5 to 15 parts, the cartilage anti-inflammatory component accounts for 1 to 10 parts, the eggshell membrane extract accounts for 10 to 30 parts, and the frankincense extract accounts for 1 to 10 parts.

[0006] In some embodiments of the present invention, the eggshell membrane extract includes at least one of collagen I, III, V, type X, elastin, keratin, glucosamine, glycosaminoglycan, lysozyme, ovotransferrin, eggshell protein, demethylated shell protein, and isodemethylated shell protein; the frankincense extract includes at least one of frankincense acids, essential oil components, glycosaminoglycans, monoterpenoids, terpenoids, and polyphenols; the cartilage repair component includes at least one of glucosamine sulfate and sodium hyaluronate; the joint supplement includes at least one of hydroxytyrosol, polyglucosamine oligosaccharides, and chondroitin sulfate; and the cartilage anti-inflammatory component includes at least one of curcumin, green tea polyphenols, and methylsulfonylmethane.

[0007] In some embodiments of the present invention, the composition further comprises a dispersant, and the dispersant comprises at least one of hydroxypropyl methylcellulose, polyvinyl alcohol, and sodium lauryl sulfate.

[0008] The present invention also provides a preparation method for preparing the above-mentioned composition for comprehensive joint care, the preparation method comprising the steps of: S1, dispersing the eggshell membrane extract and the frankincense extract in a polar solution to obtain an eggshell membrane dispersion and a frankincense dispersion; S2, adding the functional components into a vacuum mixing device, adding the dispersant in batches under a low pressure environment and stirring to obtain a base material, wherein the functional components include a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component; S3, adding the eggshell membrane dispersion and the frankincense dispersion into the base material in the vacuum mixing device respectively, performing liquid phase coating treatment, and drying after the treatment to obtain a composite powder.

[0009] In some embodiments of the present invention, step S1 comprises: S1.1, transfer the polar solution to a temperature stirring device and heat it to 30-50°C, wherein the polar solution includes at least one of deionized water, ethanol solution and acetone, and the temperature stirring device has the function of adjusting the temperature and the rotation speed; S1.2, respectively, slowly adding the eggshell membrane extract and the frankincense extract to the corresponding polar solution, stirring at a stirring speed of 200-400 rpm, and heating and stirring for 10-15 min; S1.3, maintaining the stirring speed, reducing the temperature to the cooling temperature, and obtaining the eggshell membrane dispersion and the frankincense dispersion after the stirring is completed, wherein the cooling temperature is 10-25° C., and the cooling stirring time is 3-5 min.

[0010] In some embodiments of the present invention, step S2 includes: S2.1. Preliminarily mix the cartilage repair component, the joint supplement and the cartilage anti-inflammatory component in a predetermined ratio, and stir at a low speed using a stirrer to obtain a functional component, wherein the stirring speed is 100-200 rpm and the stirring time is 10-15 min; S2.2, transferring the functional components into a vacuum mixing device, and adjusting the internal air pressure of the vacuum mixing device to a preset low pressure; S2.3, firstly divide the dispersant into n parts and add 1 / n of the dispersant into the functional component, and stir for the first time. The stirring speed of the first stirring is , The stirring speed is 100~200 rpm, and the stirring time of the first stirring is , 5~10min, then stir for the nth time until all the dispersants are added. The stirring speed for the nth time is , , the stirring time of the nth stirring is , , 50~100, k=8~10, n≤5; S2.4, degassing the functional components after adding the dispersant to obtain a base material.

[0011] In some embodiments of the present invention, step S2.4 includes: First, start stirring and increase the pressure in the mixing chamber to normal pressure, then stop stirring and reduce it to the preset low pressure until the degassing operation is completed to obtain the base material, wherein the switching cycle of starting and stopping stirring is 1 to 2 minutes, the degassing time of the degassing operation is 8 to 10 minutes, and the stirring speed of the degassing operation is the stirring speed of the nth addition of the dispersant.

[0012] In some embodiments of the present invention, the weight of the dispersant is 1-10% of the total weight of the base material.

[0013] In some embodiments of the present invention, step S3 includes: S3.1. Adjust the internal air pressure of the vacuum mixing device to a preset low pressure, slowly add the eggshell membrane dispersion into the base material in the vacuum mixing device, and stir, wherein the amount of the eggshell membrane dispersion added is 20-30% of the weight of the base material, the stirring speed is 100-200 rpm, and the stirring time is 5-10 min; S3.2, maintaining the stirring speed and then adding the frankincense dispersion, the amount of the frankincense dispersion added is the same as the amount of the eggshell membrane dispersion added, and the stirring time is 5 to 10 minutes; S3.3, adding the remaining eggshell membrane dispersion and the frankincense dispersion, increasing the stirring speed to 400-500 rpm, stirring time is 20-30 min, and completing the liquid phase coating; S3.4, stopping stirring and drying the mixture after the liquid phase coating is completed, and obtaining a composite powder after drying, wherein the drying temperature is 45-50° C. and the drying time is 200-300 min.

[0014] Compared with the prior art, the preparation method of the composition for comprehensive joint care in the present invention has the following beneficial effects: The combination of functional components such as cartilage repair components, joint supplements and cartilage anti-inflammatory components and natural ingredients such as frankincense extract and eggshell membrane extract overcomes the limitations of single-ingredient supplements, provides comprehensive anti-inflammatory, repair and lubrication treatments, has high biocompatibility, is more likely to act on the joints, and works synergistically through multiple mechanisms to improve joint function, relieve inflammation, and promote cartilage repair and protection. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic flow chart of a method for preparing a composition for comprehensive joint care in one embodiment of the present invention. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0017] Please refer to Figure 1 The present invention provides a method for preparing a composition for comprehensive joint care, the steps comprising: S1. Dispersing the eggshell membrane extract and the frankincense extract in polar solutions respectively to obtain an eggshell membrane dispersion and a frankincense dispersion.

[0018] The eggshell membrane extract includes at least one of collagen I, III, V, X type, elastin, keratin, glucosamine, glycosaminoglycan, lysozyme, ovotransferrin, eggshell protein, demethylated eggshell protein, and isodemethylated eggshell protein; the frankincense extract includes at least one of frankincense acids, essential oil components, glycosaminoglycan, monoterpenoids, terpenoids, and polyphenols.

[0019] Boswellic acids (such as 3-O-acetyl-11-keto-β-boswellic acid, abbreviated as AKBK) in frankincense extract can maintain high anti-inflammatory activity through the dispersion of polar solutions. Essential oil components (such as α-pinene) and monoterpenoids are evenly distributed during the dispersion process, which improves the stability and anti-inflammatory effect of the components. The antioxidant properties of polyphenols are maintained, which helps to reduce free radical damage to joints.

[0020] Polar solutions can dissolve the water-soluble or partially fat-soluble components in eggshell membranes and frankincense extracts, improving their absorption and utilization in the body. Collagen and glycosaminoglycans can be absorbed in smaller particles through dispersion technology, improving joint repair and lubrication effects. After dispersion, frankincense acid components are more uniform, and their anti-inflammatory activity can be quickly manifested in the body.

[0021] The cartilage repair and lubrication enhancement functions of eggshell membrane extract, combined with the anti-inflammatory and antioxidant functions of frankincense extract, can achieve a synergistic effect of joint protection and repair. This dispersed multifunctional ingredient synergistically provides a comprehensive therapeutic effect and shows significant advantages in arthritis or bone and joint repair.

[0022] The dispersed eggshell membrane dispersion and frankincense dispersion have better fluidity, which is convenient for uniform processing in subsequent coating, mixing or drying processes. The dispersed solution state allows the active ingredients to be evenly coated on the surface of the carrier particles, improving the effect and consistency of the final preparation.

[0023] Specifically, step S1 includes: S1.1. Transfer the polar solution to a temperature stirring device and heat it to 30-50°C, for example, 30°C, 40°C, or 50°C. The polar solution includes at least one of deionized water, ethanol solution, and acetone. The temperature stirring device has the function of adjusting the temperature and the rotation speed.

[0024] Heating the solution can significantly increase the dissolution rate and solubility of solutes in polar solutions. Collagen and glycosaminoglycans in eggshell membrane extracts are more easily dissolved in a warm environment, reducing the formation of insoluble particles. Ingredients such as boswellic acid and monoterpenoid compounds in frankincense extracts are better dispersed in warm solutions, forming a more uniform solution. The uniformity of the solution is improved, laying a good foundation for subsequent processing. This temperature range has been optimized to avoid the degradation of heat-sensitive components (such as collagen, boswellic acid, lysozyme, etc.) that may be caused by excessively high temperatures, while being sufficient to improve the solubility and dispersion efficiency of the components. For volatile solvents (such as ethanol and acetone) in polar solutions, the temperature is also kept within a controllable range to reduce unnecessary evaporation losses.

[0025] Stirring can introduce shear force into the liquid, further disperse the extract particles, and prevent particle precipitation and aggregation. By adjusting the stirring speed, solutions of different viscosities can be evenly mixed to ensure that the eggshell membrane and frankincense extract components are evenly dispersed in the polar solution. When the temperature is raised, the molecular activity in the extract increases, and under the action of stirring, the dispersion efficiency is higher, forming a more stable dispersion system.

[0026] S1.2. Slowly add the eggshell membrane extract and frankincense extract to the corresponding polar solution respectively, and stir at a stirring speed of 200-400 rpm, for example, 200 rpm, 300 rpm, or 400 rpm. The heating and stirring time is 10-15 min, for example, 10 min, 13 min, or 15 min.

[0027] Slowly adding the extract can avoid excessive local concentration caused by adding too much extract at one time, thereby avoiding particle precipitation or agglomeration. It improves the initial dispersion effect of the extract in the polar solution, making it easier for the active ingredients to be wrapped and dispersed by the solution. Low speed (about 200rpm) is suitable for extracts with lower density (such as frankincense extract) to avoid the introduction of bubbles or uneven dispersion due to too fast stirring. High speed (about 400rpm) is suitable for more viscous or larger particle extracts (such as eggshell membrane extract) to ensure the full dispersion and stability of the particles in the solution. The adjustability of the stirring speed can be flexibly selected according to the characteristics of the raw materials, which improves the dispersion effect of the solution.

[0028] S1.3, maintaining the stirring speed, reducing the temperature to the cooling temperature, and obtaining the eggshell membrane dispersion and the frankincense dispersion after the stirring is completed, wherein the cooling temperature is 10-25°C, for example, 10°C, 20°C, 25°C, and the cooling stirring time is 3-5 min, for example, 3 min, 4 min, 5 min.

[0029] The cooling process can reduce the molecular movement rate of the system and reduce the risk of degradation of active ingredients (such as heat-sensitive ingredients collagen, boswellic acid, etc.). The reduction in temperature makes the solutes in the solution (such as glycosaminoglycans in eggshell membrane extracts and polyphenols in frankincense extracts) more stable, preventing structural changes or inactivation that may be caused by high temperatures. The stirring process prevents particle sedimentation, ensures the uniformity of the dispersion, and improves the physical stability of the system.

[0030] S2. Add the functional components into a vacuum mixing device, add the dispersant in batches under a low pressure environment and stir to obtain a base material, wherein the functional components include a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component.

[0031] Specifically, in terms of weight, in the powdered composition, the cartilage repair component accounts for 20 to 50 parts, for example, 20 parts, 30 parts, or 50 parts; the joint supplement accounts for 5 to 15 parts, for example, 5 parts, 10 parts, or 15 parts; the cartilage anti-inflammatory component accounts for 1 to 10 parts, for example, 1 part, 5 parts, or 10 parts; the eggshell membrane dispersion accounts for 10 to 30 parts, for example, 10 parts, 20 parts, or 30 parts; the frankincense dispersion accounts for 1 to 10 parts, for example, 1 part, 5 parts, or 10 parts; the cartilage repair component includes at least one of glucosamine sulfate and sodium hyaluronate; the joint supplement includes at least one of hydroxytyrosol, polyglucosamine oligosaccharide, and chondroitin sulfate; and the cartilage anti-inflammatory component includes at least one of curcumin, green tea polyphenols, and methylsulfonylmethane.

[0032] Low-pressure stirring in a vacuum mixer can not only remove bubbles from the base material and dispersion, reduce the interference of bubbles on particle distribution, but also make the particles evenly dispersed by reducing the generation of bubbles. The low-pressure environment also promotes better contact between the dispersant and the base material, further improving the dispersion effect, helping to maintain the refinement and uniformity of the particles, avoiding particle agglomeration, and ensuring that the particle size is within the required range.

[0033] Step S2 includes: S2.1. Preliminarily mix the cartilage repair component, the joint supplement and the cartilage anti-inflammatory component in a predetermined proportion, and use a stirrer to stir at a low speed to obtain a functional component, wherein the stirring speed is 100-200 rpm, for example, 100 rpm, 150 rpm, 200 rpm, and the stirring time is 10-15 min, for example, 10 min, 13 min, 15 min.

[0034] The stirring speed is controlled at 100~200rpm to provide sufficient mixing without introducing too much air to avoid the formation of bubbles or floating particles. Ensure that the components are evenly distributed during the mixing stage, providing a good foundation for subsequent processing. After mixing according to the predetermined ratio, the distribution of the components is more uniform, avoiding excessive or low concentrations of certain components in the final product, thereby ensuring the consistency of the performance of the functional components.

[0035] S2.2. Transfer the functional components to the vacuum mixing device, and adjust the internal air pressure of the vacuum mixing device to a preset low pressure, the preset low pressure is -0.08~-0.1MPa, for example, it can be -0.08MPa, -0.09MPa, -0.1MPa, the low pressure parameter is the reading on the vacuum pressure gauge, the specific structure and use of the vacuum pressure gauge are known to those skilled in the art, and will not be repeated here.

[0036] Under low pressure, bubbles in the mixed material will expand and burst rapidly due to the pressure drop, and then be removed by the vacuum system. Effectively remove the air that may be introduced during the initial stirring to prevent bubbles from having adverse effects on subsequent coating or compression molding processes. After the bubbles are removed, the internal density of the functional components is more uniform, reducing material defects caused by bubbles.

[0037] Under low pressure, the interaction force between particles is weakened, which increases the free movement of particles and promotes the redispersion of components in the functional components. Especially for materials with high viscosity, low pressure can significantly improve the mixing uniformity and avoid stratification between components.

[0038] S2.3, first divide the dispersant into n parts and add 1 / n of the dispersant to the functional component, and stir for the first time. The stirring speed of the first stirring is , The stirring speed is 100~200 rpm, and the stirring time of the first stirring is , 5~10min, then stir for the nth time until all the dispersants are added. The stirring speed for the nth time is , , the stirring time of the nth stirring is , , =50~100, k=8~10, n≤5.

[0039] Add dispersant in batches under low pressure and stir gradually to ensure full contact and uniform dispersion of functional components and dispersant. Each time the stirring speed is gradually increased to ensure a deeper dispersion process and reduce agglomeration.

[0040] Through multiple dispersions and staged stirring, the cartilage repair components, joint supplements and cartilage anti-inflammatory components can be more evenly distributed in the base material under a low-pressure environment, thereby improving the uniformity and stability of the composition, and ultimately preparing a high-quality joint care composition.

[0041] Adding dispersant in batches can avoid the problem of a sudden increase in viscosity caused by adding it all at once and reduce stirring resistance. Gradually increasing the stirring speed helps to improve mixing efficiency and save preparation time. Stirring in a low-pressure environment can effectively avoid the introduction of air and reduce the problem of performance degradation of the composition caused by bubble formation.

[0042] By gradually increasing the speed and time of the mixing, the method can be flexibly adjusted to adapt to the gradually increasing material mass, with strong mixing force and good uniform dispersion. The optimized mixing process can make the cartilage repair components, joint supplements and anti-inflammatory components more evenly distributed in the base material, thereby enhancing the synergistic effect of these ingredients in joint care.

[0043] S2.4. Degassing the functional components after adding the dispersant to obtain the base material.

[0044] Step S2.4 includes: First, start stirring and increase the pressure in the mixing chamber to normal pressure, then stop stirring and reduce it to a preset low pressure until the degassing operation is completed to obtain the base material, wherein the switching cycle of starting and stopping stirring is 1 to 2 minutes, for example, it can be 1 minute, 1.5 minutes, 2 minutes, the degassing time of the degassing operation is 8 to 10 minutes, for example, it can be 8 minutes, 9 minutes, 10 minutes, and the stirring speed of the degassing operation is the stirring speed of the nth addition of the dispersant.

[0045] Increasing the mixing chamber pressure to normal pressure at the beginning of stirring helps to reduce the volume of bubbles in the mixing system, thereby reducing the residual bubbles during the stirring process. Subsequently, by reducing the mixing chamber pressure to a preset low pressure, combined with the stirring operation, the bubbles are promoted to escape quickly from the mixing system, significantly improving the degassing efficiency.

[0046] The alternating switching of starting and stopping stirring can effectively reduce the problem of reintroduction of bubbles caused by stirring, thereby further improving the degassing effect. After the bubbles are completely removed, the density and uniformity of the base material are enhanced, providing a better raw material basis for the subsequent liquid coating and drying steps, and ultimately improving the functionality and reliability of the prepared composite powder in application.

[0047] S3, adding the eggshell membrane dispersion and the frankincense dispersion into the base material in the vacuum mixing device respectively, performing liquid phase coating treatment, and drying after the treatment to obtain the composite powder.

[0048] The eggshell membrane dispersion and frankincense dispersion are added to the base material respectively, and the active ingredients (such as collagen, frankincense acid, etc.) in the eggshell membrane and frankincense extract are evenly coated on the surface of the particles through liquid phase coating. Liquid phase coating can not only improve the bioavailability of active ingredients, but also increase their effect in joint treatment and prolong the action time of the ingredients. The base material after coating can remain stable and is not easy to precipitate or stratify, which enhances the stability of the formula.

[0049] Cartilage repair components (such as glucosamine, chondroitin sulfate), anti-inflammatory components (such as AKBA in Boswellia extract) and cartilage anti-inflammatory components (such as MSM) work synergistically in the same formula to provide comprehensive joint protection. This combination not only promotes cartilage repair, but also relieves joint pain through anti-inflammatory effects and improves joint lubricity and elasticity.

[0050] The drying process can effectively remove solvents and moisture, making the active ingredients in the formula stable in a solid state and able to be stored for a long time. This treatment method prevents the degradation of active ingredients in liquid form and improves the stability and storage period of the product.

[0051] By using natural ingredients (such as frankincense extract and eggshell membrane extract) and gentle physical processing methods (such as low pressure and liquid phase coating), this process can provide a joint treatment formula that is safer, environmentally friendly and has fewer side effects. Through natural ingredients and optimized dispersion technology, the use of chemical ingredients is reduced, reducing potential risks to patients.

[0052] The coated base material has a high absorption efficiency in the joints, which can effectively improve the efficacy of the drug. Due to the application of dispersion and coating technology, the active ingredients can be quickly absorbed by the joints and directly reach the target area, thereby improving the treatment effect.

[0053] Specifically, step S3 includes: S3.1. Adjust the internal air pressure of the vacuum mixing device to a preset low pressure, slowly add the eggshell membrane dispersion into the base material in the vacuum mixing device, and stir, wherein the amount of the eggshell membrane dispersion added is 20-30% by weight of the base material, for example, 20%, 25%, 30%, the stirring speed is 100-200 rpm, for example, 100 rpm, 150 rpm, 200 rpm, the stirring time is 5-10 min, for example, 5 min, 8 min, 10 min, and the preset low pressure is -0.08-0.1 MPa, for example, -0.08 MPa, -0.09 MPa, -0.1 MPa.

[0054] Operating under a low-pressure environment can reduce the gas content in the base material, effectively reduce the interference of bubbles on the dispersion process, and enhance the uniform mixing effect of the eggshell membrane dispersion and the base material.

[0055] Eggshell membrane dispersion contains high molecular weight components (such as collagen, glycosaminoglycans, etc.), which will significantly increase the viscosity of the mixed system when added to the base. If too much dispersion is added at one time, it may increase the load on the stirring paddle, reduce the stirring efficiency, and even cause uneven mixing. Adding in batches can steadily increase the viscosity of the system, ensure a smooth stirring process, and avoid clogging or overloading the stirring paddle. Adding in batches allows each portion of the eggshell membrane dispersion to be fully mixed with the base after addition, reducing the formation of local high concentration areas and avoiding uneven distribution of components. By adding in batches and stirring gradually, the eggshell membrane components can be evenly distributed throughout the base, thereby improving the consistency of the composition.

[0056] In one embodiment, during the addition of the eggshell membrane dispersion and the frankincense dispersion, a small amount of natural oil (such as avocado oil or evening primrose oil, the addition amount is 1-2% of the total base material weight) is mixed and added, and stirred at a low speed (100-150 rpm) for 5 minutes, and then gradually increased to 200-250 rpm for 2-3 minutes, so that the oil forms a primary film on the surface of the base material.

[0057] The lubricity and molecular adsorption capacity of natural oils are used to enhance the surface adhesion of functional ingredients, and a thin protective film is formed by stirring at an increased speed to prevent the ingredients from being directly exposed to the air. This improves the stability of active ingredients and reduces the risk of oxidation and degradation. It also improves the fluidity of powder particles and increases the uniformity of the preparation process.

[0058] S3.2. Maintain the stirring speed and add frankincense dispersion. The amount of frankincense dispersion added is the same as the amount of eggshell membrane dispersion added. The stirring time is 5 to 10 minutes, for example, 5 minutes, 8 minutes, or 10 minutes.

[0059] In the base material where the eggshell membrane dispersion is evenly distributed, maintaining the same stirring speed and gradually adding the frankincense dispersion can ensure that the frankincense dispersion and the base material are fully mixed, avoiding the problem of uneven distribution caused by mismatching stirring parameters. The functional components in the frankincense dispersion (such as frankincense acids, polyphenol compounds, etc.) can be evenly distributed in the base material, avoiding local concentrations that are too high or too low, and improving the overall uniformity of the final composition.

[0060] Frankincense dispersions may contain thermosensitive or mechanically sensitive components (such as monoterpenoids and essential oil components). Operating within a moderate stirring speed and time range can maximize the protection of these active ingredients and avoid degradation or reduced activity due to excessive stirring or prolonged exposure. The stability of the active ingredients in the frankincense dispersion is ensured so that their biological functions in the composition can be fully exerted.

[0061] The addition amount of mastic dispersion is the same as that of eggshell membrane dispersion, which can ensure that the viscosity and fluidity of the entire system are within a reasonable range, avoiding a sudden increase in system viscosity or uneven dispersion caused by adding too much mastic dispersion at one time. Maintaining the stable rheological properties of the system is conducive to the smooth progress of subsequent operations such as liquid coating and drying steps.

[0062] S3.3, add the remaining eggshell membrane dispersion and frankincense dispersion, increase the stirring speed to 400-500 rpm, for example, 400 rpm, 450 rpm, 500 rpm, the stirring time is 20-30 min, for example, 20 min, 25 min, 30 min, to complete the liquid phase coating.

[0063] Liquid phase coating uses the surface active components (such as collagen, boswellic acid, etc.) in eggshell membrane dispersion and frankincense dispersion to form a physical or chemical adsorption layer on the surface of the base material particles. These components are evenly distributed on the surface of the base material particles through intermolecular forces (such as van der Waals forces, hydrogen bonds or electrostatic interactions) to form a stable coating layer.

[0064] When the stirring speed is increased to 400-500 rpm, the functional components in the liquid medium can be further evenly dispersed under the action of high-speed shear force and fully contact with the base material to achieve efficient coating. The eddy current and turbulence generated by stirring enhance the interface contact between the base material and the liquid dispersion and promote the formation of the coating layer.

[0065] The viscous properties of collagen and glycosaminoglycans in the eggshell membrane dispersion, as well as the cross-linking ability of polyphenols and terpenoids in the frankincense dispersion, make the coating more dense and stable. As the stirring time increases, the coating gradually forms a film, and the functional components are evenly coated on the surface of the base material. The low-pressure environment further reduces the bubbles in the liquid phase, making the coating denser and avoiding the influence of bubble inclusions on the coating uniformity.

[0066] During the coating process, the functional ingredients are evenly coated on the base material, which reduces the exposure area of ​​the active ingredients and reduces the risk of degradation in subsequent processing. The stability and activity retention rate of the functional ingredients (such as collagen, boswellic acid, etc.) in the composition are improved. The active ingredients (such as collagen, boswellic acid, polyphenols) in the coating layer can be evenly released and work together with the base material to enhance the overall biological properties of the joint care composition. Provide more efficient anti-inflammatory, cartilage repair and joint nutrition functions.

[0067] S3.4, stopping stirring and drying the mixture after liquid phase coating, and obtaining a composite powder after drying, wherein the drying temperature is 45-50°C, for example, 45°C, 48°C, 50°C, and the drying time is 200-300 min, for example, 200 min, 250 min, 300 min.

[0068] During the liquid phase coating process, a certain amount of polar solvents (such as deionized water, ethanol, etc.) may remain on the surface and inside of the base material. By setting the temperature and continuously drying, these solvents can be effectively evaporated to ensure that the composite powder has no solvent residue, thereby improving the purity and quality of the product.

[0069] The functional components in eggshell membrane dispersion and frankincense dispersion (such as collagen, frankincense acid, lysozyme, etc.) are sensitive to high temperature. Setting the drying temperature in the moderate temperature range of 45-50°C can not only meet the requirements of solvent evaporation, but also avoid the denaturation or degradation of active ingredients caused by high temperature. The biological activity and anti-inflammatory and repair properties of the functional components are retained to ensure the overall effect of the composition.

[0070] Under appropriate drying temperature and time, the eggshell membrane and frankincense components in the coating layer can gradually solidify to form a dense and stable coating layer, avoiding cracking or peeling that may be caused by rapid drying. The coating layer is complete and uniform, ensuring the structural stability and uniformity of the composite powder in subsequent use.

[0071] After the solvent is completely removed during the drying process, the adhesion between the powder particles is reduced, the fluidity and dispersibility of the powder are improved, and the problem of the powder absorbing moisture and agglomerating due to the residual solvent is avoided. The composite powder has better fluidity, is suitable for subsequent processing or direct packaging, and has longer storage stability.

[0072] The equipment, devices and other mechanical structures used in all the embodiments of the present invention are known to those skilled in the art, and the specific use methods and working principles will not be described in detail.

[0073] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition for comprehensive joint care, characterized in that: The composition comprises an eggshell membrane extract, an frankincense extract, a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component. In terms of weight, in the powder of the composition, the cartilage repair component accounts for 20 to 50 parts, the joint supplement accounts for 5 to 15 parts, the cartilage anti-inflammatory component accounts for 1 to 10 parts, the eggshell membrane extract accounts for 10 to 30 parts, and the frankincense extract accounts for 1 to 10 parts.

2. The composition for comprehensive joint care according to claim 1, characterized in that: The eggshell membrane extract comprises at least one of collagen I, III, V, and X, elastin, keratin, glucosamine, glycosaminoglycan, lysozyme, ovotransferrin, eggshell protein, demethylated shell protein, and isodemethylated shell protein; the frankincense extract comprises at least one of frankincense acids, essential oil components, glycosaminoglycans, monoterpenoid compounds, terpenoid compounds, and polyphenol compounds; the cartilage repair component comprises at least one of glucosamine sulfate and sodium hyaluronate; the joint supplement comprises at least one of hydroxytyrosol, polyglucosamine oligosaccharides, and chondroitin sulfate; and the cartilage anti-inflammatory component comprises at least one of curcumin, green tea polyphenols, and methylsulfonylmethane.

3. The composition for comprehensive joint care according to claim 1, characterized in that: The composition further comprises a dispersant, and the dispersant comprises at least one of hydroxypropyl methylcellulose, polyvinyl alcohol, and sodium lauryl sulfate.

4. A preparation method, characterized in that: Used to prepare the composition for comprehensive joint care according to any one of claims 1 to 3, the preparation method comprising the steps of: S1, dispersing the eggshell membrane extract and the frankincense extract in polar solutions to obtain an eggshell membrane dispersion and a frankincense dispersion; S2, adding the functional components into a vacuum mixing device, adding the dispersant in batches under a low pressure environment and stirring to obtain a base material, wherein the functional components include a cartilage repair component, a joint supplement and a cartilage anti-inflammatory component; S3, adding the eggshell membrane dispersion and the frankincense dispersion into the base material in the vacuum mixing device respectively, performing liquid phase coating treatment, and drying after the treatment to obtain a composite powder.

5. The preparation method according to claim 4, characterized in that: The step S1 comprises: S1.1, transfer the polar solution to a temperature stirring device and heat it to 30-50°C, wherein the polar solution includes at least one of deionized water, ethanol solution and acetone, and the temperature stirring device has the function of adjusting the temperature and the rotation speed; S1.2, respectively, slowly adding the eggshell membrane extract and the frankincense extract to the corresponding polar solution, stirring at a stirring speed of 200-400 rpm, and heating and stirring for 10-15 min; S1.3, maintaining the stirring speed, reducing the temperature to the cooling temperature, and obtaining the eggshell membrane dispersion and the frankincense dispersion after the stirring is completed, wherein the cooling temperature is 10-25° C., and the cooling stirring time is 3-5 min.

6. The preparation method according to claim 4, characterized in that: The step S2 comprises: S2.

1. Preliminarily mix the cartilage repair component, the joint supplement and the cartilage anti-inflammatory component in a predetermined ratio, and stir at a low speed using a stirrer to obtain a functional component, wherein the stirring speed is 100-200 rpm and the stirring time is 10-15 min; S2.2, transferring the functional components into a vacuum mixing device, and adjusting the internal air pressure of the vacuum mixing device to a preset low pressure; S2.3, firstly divide the dispersant into n parts and add 1 / n of the dispersant into the functional component, and stir for the first time. The stirring speed of the first stirring is , The stirring speed is 100~200 rpm, and the stirring time of the first stirring is , 5~10min, then stir for the nth time until all the dispersants are added. The stirring speed for the nth time is , , the stirring time of the nth stirring is , , =50~100, k=8~10, n≤5; S2.4, degassing the functional components after adding the dispersant to obtain a base material.

7. The preparation method according to claim 6, characterized in that: The step S2.4 comprises: First, start stirring and increase the pressure in the mixing chamber to normal pressure, then stop stirring and reduce it to the preset low pressure until the degassing operation is completed to obtain the base material, wherein the switching cycle of starting and stopping stirring is 1 to 2 minutes, the degassing time of the degassing operation is 8 to 10 minutes, and the stirring speed of the degassing operation is the stirring speed of the nth addition of the dispersant.

8. The preparation method according to claim 4 or 6, characterized in that: The weight of the dispersant is 1-10% of the total weight of the base material.

9. The preparation method according to claim 4, characterized in that: The step S3 comprises: S3.

1. Adjust the internal air pressure of the vacuum mixing device to a preset low pressure, slowly add the eggshell membrane dispersion into the base material in the vacuum mixing device, and stir, wherein the amount of the eggshell membrane dispersion added is 20-30% of the weight of the base material, the stirring speed is 100-200 rpm, and the stirring time is 5-10 min; S3.2, maintaining the stirring speed and then adding the frankincense dispersion, the amount of the frankincense dispersion added is the same as the amount of the eggshell membrane dispersion added, and the stirring time is 5 to 10 minutes; S3.3, adding the remaining eggshell membrane dispersion and the frankincense dispersion, increasing the stirring speed to 400-500 rpm, stirring time is 20-30 min, and completing the liquid phase coating; S3.4, stopping stirring and drying the mixture after the liquid phase coating is completed, and obtaining a composite powder after drying, wherein the drying temperature is 45-50° C. and the drying time is 200-300 min.

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