Plant itching-relieving shampoo

Abstract

The invention relates to plant itching-relieving shampoo. The preparation method comprises the following steps: reacting 30 to 40 parts of glycerol, 0.5 to 2.2 parts of papain, 0.03 to 0.3 part of p-vinyl guaiacol, 0.08 to 0.8 part of citronellol and 0.5 to 2 parts of baking soda at 50 to 60 DEG C for 1 to 3 hours; adding 0.1-0.3 part of guar gum hydroxypropyl trimethyl ammonium chloride, dispersing and mixing by using a homogenizer, and uniformly stirring; cooling, adding 1.5-2.5 parts of a radix gentianae extract, 1.5-2.5 parts of a cacumen biotae extract, 0.3-0.8 part of a radix sophorae flavescentis extract, 0.03-0.08 part of a cnidium monnieri fruit extract, 1.5-2.5 parts of a swertia japonica extract, 0.5-1.5 parts of a ginger root extract and 1.5-2.5 parts of a peony root extract, stirring until the components are completely dissolved, and filtering to obtain the plant itching-relieving shampoo. The plant antipruritic shampoo prepared by the invention has excellent antibacterial activity and antipruritic effect.

Description

Technical Field

[0001] The invention relates to the technical field of shampoo, in particular to a plant antipruritic shampoo. Background Art

[0002] Seborrheic dermatitis is a chronic, recurrent inflammatory scalp disease characterized by the formation of erythema or mild to moderate scales, causing greasy scalp and flaky dandruff accompanied by itching. Among adults, its prevalence is as high as 5%, and choosing anti-dandruff shampoo products is the first choice for people to solve this problem.

[0003] Chinese patent CN113730278B: provides an anti-dandruff and antipruritic shampoo. By using a combination of anionic, cationic, amphoteric and non-ionic surfactants, a shampoo with high foaming properties, stability, suitable viscosity and low irritation to the scalp is obtained. The conversion rate of oxidized chloropyridine is improved by catalytic oxidation of chloropyridine through diffusion of oxygen. The process is extremely short in time. While maintaining a high conversion rate and selectivity, the production efficiency is significantly improved. Furthermore, when preparing the shampoo anti-dandruff and antipruritic agent ZPT, the purity and conversion rate of the product are further improved, wherein the heavy metal content of ZPT is less than 3.5ppm.

[0004] Chinese patent CN113876666B: relates to the technical field of shampoo products, specifically to an anti-dandruff and anti-itching shampoo and its preparation method. The anti-dandruff and anti-itching shampoo is made of the following raw material components in weight percentage: 0.2-0.8% of nasturtium extract, 0.1-0.5% of sophora flavescens root extract, 0.1-0.5% of albizzia julibrissin bark extract, 0.8-1.2% of anti-dandruff agent, 3-5% of hair conditioner, 3-5% of surfactant, 0.02-0.05% of antistatic agent, 8-12% of foaming agent, 2-4% of moisturizing agent, 0.1-0.4% of viscosity regulator, 0.2-0.4% of phenoxyethanol, 0.2-0.3% of ethylhexylglycerin, 0.1-0.2% of sodium benzoate, 0.2-0.4% of essence, and the balance of deionized water.

[0005] Chinese patent CN112754983B: discloses a shampoo, specifically relates to an anti-dandruff and anti-itching shampoo and a preparation method thereof. The anti-dandruff and anti-itching shampoo of the present invention is composed of guar hydroxypropyltrimethylammonium chloride, citric acid, sodium methyl cocoyl taurate, sodium cocoyl glutamate, methyl glucose dioleate, hydrolyzed corn starch, zinc pyrithione emulsion and deionized water.

[0006] The shampoo prepared by the above patents and prior art has poor antibacterial performance against Malassezia furfur and Candida albicans, and cannot relieve various fungal infections of the scalp, resulting in poor antipruritic performance. Summary of the invention

[0007] In order to solve the above problems, the present invention provides a plant antipruritic shampoo, the operation steps of which are as follows:

[0008] S1: by weight, 30-40 parts of glycerol, 0.5-2.2 parts of papain, 0.03-0.3 parts of p-vinyl guaiacol, 0.08-0.8 parts of citronellol, and 0.5-2 parts of baking soda are stirred and heated for reaction;

[0009] S2: Add 0.1-0.3 parts of guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly;

[0010] S3: Cool down, add 1.5-2.5 parts of gentian root extract, 1.5-2.5 parts of Platycladus orientalis leaf extract, 0.3-0.8 parts of Sophora flavescens root extract, 0.03-0.08 parts of Cnidium monnieri fruit extract, 1.5-2.5 parts of Swertia japonica extract, 0.5-1.5 parts of ginger root extract, 1.5-2.5 parts of Paeonia suffruticosa root extract, stir until completely dissolved, filter, and obtain the plant antipruritic shampoo.

[0011] The stirring rate is 100-300 rpm.

[0012] The reaction temperature of S1 is 50-60°C and the reaction time is 1-3h.

[0013] The temperature of S3 is lowered to 30-35°C.

[0014] Reaction mechanism

[0015] Papain is a thiol protease with key cysteine ​​residues (Cys) in its active center. The thiol groups (-SH) on these residues play a vital role in the catalytic process. When papain comes into contact with vinyl guaiacol, the thiol groups of papain can attack the double bonds in vinyl guaiacol to form new chemical bonds. The reaction between papain and citronellol also involves the interaction between the active center of the enzyme and the citronellol molecule.

[0016] Technical Effects

[0017] The plant antipruritic shampoo of the present invention has the following significant effects compared with the prior art:

[0018] 1. Enhance the anti-dandruff and anti-itching effects:

[0019] Guaiacol and citronellol are natural ingredients with antibacterial, anti-inflammatory and scalp-soothing properties; papain may enhance the efficacy of these ingredients by binding with them, thereby more effectively relieving scalp itching and reducing dandruff.

[0020] 2. Improve cleaning power:

[0021] Papain itself has a good ability to hydrolyze protein, which helps remove oil, dirt, and dead skin cells from the scalp and hair; when papain is combined with guaiacol and citronellol, it may further enhance the shampoo's cleansing ability and make the scalp more refreshed.

[0022] 3. Improve scalp environment:

[0023] The synergistic effect of papain with guaiacol and citronellol may help regulate the pH of the scalp, reduce scalp irritation, and promote a healthier scalp. This improved scalp environment helps reduce the occurrence of scalp problems such as itchy scalp, dandruff, etc.

[0024] 4. Gentle and non-irritating:

[0025] Since papain, guaiacol, and citronellol are all naturally derived ingredients, shampoos made from them are generally gentler and less irritating than products containing synthetic chemicals; this is a significant advantage for those with sensitive scalps or those seeking natural treatments.

[0026] In summary, the addition reaction of papain with vinyl guaiacol and citronellol improves the shampooing effect of plant antipruritic shampoo by enhancing the anti-dandruff and antipruritic effects, improving the cleaning power, improving the scalp environment and maintaining mildness and non-irritation. DETAILED DESCRIPTION

[0027] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following is a detailed description in combination with embodiments and comparative examples:

[0028] 1. Antibacterial test: The anti-dandruff effect of the shampoo sample is evaluated according to the size of the antibacterial circle formed, referring to the result judgment standard of the antibacterial ring experiment in WS / T650-2019 "Antibacterial and Antibacterial Effect Evaluation Method". Those with a diameter greater than 7mm have antibacterial effect.

[0029] 2. Antipruritic performance test: 140 patients with obvious scalp skin diseases such as dandruff and seborrheic dermatitis were selected as subjects (half male and half female, aged 20-50 years old). They were randomly divided into 7 groups, with 20 people in each group. Each volunteer used the shampoo twice a week for two consecutive months, and the scalp itching was observed.

[0030] The test results are shown in Table 1.

[0031] Example 1

[0032] A plant antipruritic shampoo, the operation steps of which are:

[0033] S1: 30g glycerol, 0.5g papain, 0.03g p-vinyl guaiacol, 0.08g citronellol, and 0.5g baking soda were stirred and heated to react;

[0034] S2: Add 0.1g guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly;

[0035] S3: Cool down, add 1.5g of gentian root extract, 1.5g of Platycladus orientalis leaf extract, 0.3g of Sophora flavescens root extract, 0.03g of Cnidium monnieri fruit extract, 1.5g of Swertia japonica extract, 0.5g of Zingiber officinale root extract, and 1.5g of Paeonia suffruticosa root extract, stir until completely dissolved, filter, and obtain a plant antipruritic shampoo.

[0036] The stirring rate is 100 rpm.

[0037] The reaction temperature of S1 is 50°C and the reaction time is 1h.

[0038] The temperature of S3 is lowered to 30°C.

[0039] Example 2

[0040] A plant antipruritic shampoo, the operation steps of which are:

[0041] S1: 33g glycerol, 1g papain, 0.1g p-vinyl guaiacol, 0.3g citronellol and 1g baking soda were stirred and heated to react;

[0042] S2: Add 0.2g of guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly;

[0043] S3: Cool down, add 1.8g gentian root extract, 1.8g oriental arborvitae leaf extract, 0.5g sophora flavescens root extract, 0.05g cnidium monnieri extract, 1.8g scutellaria japonica extract, 0.8g ginger root extract, 1.8g peony root extract, stir until completely dissolved, filter, and obtain the plant antipruritic shampoo.

[0044] The stirring rate is 150 rpm.

[0045] The reaction temperature of S1 is 55°C and the reaction time is 2h.

[0046] The temperature of S3 is lowered to 32°C.

[0047] Example 3

[0048] A plant antipruritic shampoo, the operation steps of which are:

[0049] S1: 38g glycerol, 2g papain, 0.2g p-vinyl guaiacol, 0.6g citronellol, and 1.5g baking soda were stirred and heated to react;

[0050] S2: Add 0.2g of guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly;

[0051] S3: Cool down, add 2.3g of gentian root extract, 2.3g of Platycladus orientalis leaf extract, 0.7g of Sophora flavescens root extract, 0.07g of Cnidium monnieri fruit extract, 2.3g of Swertia japonica extract, 1.3g of Zingiber officinale root extract, and 2.3g of Paeonia suffruticosa root extract, stir until completely dissolved, filter, and obtain a plant antipruritic shampoo.

[0052] The stirring rate is 250 rpm.

[0053] The reaction temperature of S1 is 55°C and the reaction time is 2h.

[0054] The temperature of S3 is lowered to 34°C.

[0055] Example 4

[0056] A plant antipruritic shampoo, the operation steps of which are:

[0057] S1: 40g glycerol, 2.2g papain, 0.3g p-vinyl guaiacol, 0.8g citronellol and 2g baking soda were stirred and heated to react;

[0058] S2: Add 0.3g of guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly;

[0059] S3: Cool down, add 2.5g of gentian root extract, 2.5g of Platycladus orientalis leaf extract, 0.8g of Sophora flavescens root extract, 0.08g of Cnidium monnieri fruit extract, 2.5g of Swertia japonica extract, 1.5g of ginger root extract, and 2.5g of peony root extract, stir until completely dissolved, filter, and obtain a plant antipruritic shampoo.

[0060] The stirring rate is 300 rpm.

[0061] The reaction temperature of S1 is 60°C and the reaction time is 3h.

[0062] The temperature of S3 is lowered to 35°C.

[0063] Comparative Example 1

[0064] The other steps were the same as in Example 1 except that papain, p-vinylguaiacol and citronellol were not added.

[0065] Comparative Example 2

[0066] Without adding p-vinyl guaiacol, the other steps were the same as those in Example 1.

[0067] Comparative Example 3

[0068] Without adding citronellol, the other steps were the same as in Example 1.

[0069] Table 1

[0070]

[0071]

[0072] Through the data analysis of the above embodiments and comparative examples, the plant antipruritic shampoo prepared by the present invention has excellent antibacterial and antipruritic effects.

[0073] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A plant antipruritic shampoo, the operation steps of which are: S1: by weight, 30-40 parts of glycerol, 0.5-2.2 parts of papain, 0.03-0.3 parts of p-vinyl guaiacol, 0.08-0.8 parts of citronellol, and 0.5-2 parts of baking soda are stirred and heated for reaction; S2: Add 0.1-0.3 parts of guar gum hydroxypropyltrimethylammonium chloride, disperse and mix with a homogenizer, and stir evenly; S3: Cool down, add 1.5-2.5 parts of gentian root extract, 1.5-2.5 parts of Platycladus orientalis leaf extract, 0.3-0.8 parts of Sophora flavescens root extract, 0.03-0.08 parts of Cnidium monnieri fruit extract, 1.5-2.5 parts of Swertia japonica extract, 0.5-1.5 parts of ginger root extract, 1.5-2.5 parts of Paeonia suffruticosa root extract, stir until completely dissolved, filter, and obtain the plant antipruritic shampoo.

2. A plant antipruritic shampoo according to claim 1, characterized in that: The stirring rate is 100-300 rpm.

3. A plant antipruritic shampoo according to claim 1, characterized in that: The reaction temperature of S1 is 50-60°C and the reaction time is 1-3h.

4. A plant antipruritic shampoo according to claim 1, characterized in that: The temperature of S3 is lowered to 30-35°C.

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