Whitening skin care essence lotion and preparation method thereof

Abstract

The invention discloses a whitening skin care essence milk and a preparation method thereof, belonging to the technical field of whitening skin care products. The essence milk comprises an A component and a B component. The A component comprises the following components in parts by weight: 4-8 parts of dimethicone, 1-3 parts of capric triglyceride, 3-8 parts of ethyl ferulate-loaded nanoliposomes, 0.5-1 parts of polydimethylsiloxane, 0.5-1 parts of decamethylcyclopentasiloxane, 0.05-0.1 parts of butylated hydroxyanisole, 0.5-1 parts of sodium hyaluronate, 2-4 parts of nicotinamide, 3-5 parts of arbutin, 1-5 parts of vitamin E acetate and 25-40 parts of water; and the B component comprises the following components in parts by weight: 2-5 parts of betaine, 3-5 parts of glyceryl stearate, 0.1-0.5 parts of carbomer and 0.01-0.1 parts of triethanolamine. The present invention significantly improves skin permeability by compounding DSPE-PEG and squalane, so that ethyl ferulate can be more efficiently absorbed and utilized by the skin, ensuring its stability during storage and use, keeping the skin moisturized, and not causing adverse stimulation. The invention has the characteristics of small average particle size, uniform distribution, and good stability.

Description

Technical Field

[0001] The invention belongs to the technical field of whitening skin care products, and in particular relates to a whitening skin care essence lotion and a preparation method thereof. Background Art

[0002] In today's beauty and skin care field, whitening has always been one of the important goals pursued by many consumers. With the changes in living environment and the continuous improvement of people's requirements for their own image, the whitening skin care product market is showing a booming trend. Consumers expect to improve uneven skin tone, reduce pigmentation and enhance the overall whiteness of the skin by using whitening products. However, existing whitening skin care products face many challenges in terms of efficacy realization and ingredient application. Traditional whitening ingredients such as hydroquinone, although they have certain whitening effects, are strictly restricted in use due to their potential toxicity and irritation. In recent years, some relatively mild ingredients with whitening potential have received more attention, such as niacinamide, arbutin, etc., but a single ingredient is often difficult to meet consumers' demand for efficient and safe whitening products. Therefore, the development of skin care products containing multiple effective whitening ingredients with good synergy has become a key research direction.

[0003] As a natural plant product, ethyl ferulate has many potential health benefits. Its antioxidant properties can remove free radicals, which are the cause of skin aging, dullness and pigmentation. Antioxidants can prevent and improve these skin problems. Its anti-inflammatory properties can inhibit inflammatory signaling pathways and relieve skin redness, swelling and pigmentation caused by inflammation. Although neuroprotective function has been less studied in skin care, it may help maintain the normal function of skin nerve endings and affect skin perception, metabolism and self-repair. Antiproliferative activity has potential significance for preventing abnormal skin proliferation, such as inhibiting some pre-lesions of skin tumors. However, ethyl ferulate has poor solubility and stability. Insolubility in water limits its application in water-based skin care products, making it difficult to evenly disperse in the formula system, resulting in unstable product quality and difficulty in fully exerting the active ingredients. Poor stability makes it susceptible to oxidation and photolysis during storage and use due to light, temperature, oxygen, etc., and loses its activity. Low bioavailability also makes skin absorption and utilization efficiency low, and the skin care effect cannot be fully demonstrated. Nanoliposome technology can solve the above problems. Loading active ingredients can improve water solubility and allow water-insoluble ingredients to be evenly dispersed in the water-based system. Its lipid bilayer can serve as a physical barrier to enhance the protection of active ingredients and improve stability. The nanoscale size is conducive to contact and penetration with the skin, increasing the transdermal rate and allowing more active ingredients to penetrate the skin to take effect. Therefore, using nanoliposomes to load ethyl ferulate is extremely critical to the development of efficient, stable and safe whitening skin care products. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention rationally compounds ethyl ferulate-loaded nanoliposomes with a variety of skin care ingredients, achieves multi-ingredient synergistic enhancement, enhances the whitening and skin care effects, and has good stability and safety.

[0005] In order to achieve the above-mentioned purpose, the following technical scheme is adopted: on the one hand, the present invention provides a whitening skin care essence lotion, comprising component A and component B; the component A comprises the following components in parts by weight: 4-8 parts of dimethicone, 1-3 parts of capric triglyceride, 3-8 parts of ethyl ferulate nanoliposomes, 0.5-1 parts of polydimethylsiloxane, 0.5-1 parts of decamethylcyclopentasiloxane, 0.05-0.1 parts of butylated hydroxyanisole, 0.5-1 parts of sodium hyaluronate, 2-4 parts of niacinamide, 3-5 parts of arbutin, 1-5 parts of vitamin E acetate and 25-40 parts of water; the component B comprises the following components in parts by weight: 2-5 parts of betaine, 3-5 parts of glyceryl stearate, 0.1-0.5 parts of carbomer and 0.01-0.1 parts of triethanolamine.

[0006] Furthermore, the ethyl ferulate-loaded nanoliposomes are prepared by the following steps:

[0007] S1, adding squalane and DSPE-PEG to a mixed solution of N,N-dimethylformamide and triethylamine, adding sodium hydroxide to adjust the pH to 8.5, then stirring at room temperature for 24 hours, dialyzing the resulting solution with a 3.5 kD dialysis membrane for 36-72 hours, and then freeze-drying to obtain a squalane-DSPE-PEG complex;

[0008] S2. The squalane-DSPE-PEG complex and ethyl ferulate are heated to 80-100° C. to obtain an oil phase, and deionized water and Tween-60 are mixed and stirred at 400-600 rpm for 15-30 min to obtain an aqueous phase, and the aqueous phase is quickly added to the oil phase, and stirred at 400-600 rpm for 20-40 min to obtain the ethyl ferulate-loaded nanoliposomes.

[0009] Furthermore, the mass ratio of component A to component B is 3-5:1.

[0010] Furthermore, in step S1, the mass ratio of squalane, DSPE-PEG, N,N-dimethylformamide and triethylamine is 1:2-4:20-40:0.5-1.5.

[0011] Furthermore, in step S2, the mass ratio of squalane-DSPE-PEG complex to ethyl ferulate is 1:3-6.

[0012] Furthermore, in step S2, the mass ratio of deionized water to Tween-60 is 10-20:1.

[0013] Furthermore, in step S2, the mass ratio of the water phase to the oil phase is 3-5:1.

[0014] Furthermore, the DSPE-PEG is one of DSPE-PEG1000, DSPE-PEG2000 and DSPE-PEG3400.

[0015] On the other hand, the present invention also provides a method for preparing a whitening skin care essence lotion, comprising the following steps:

[0016] (1) Weigh all the raw materials of component B according to the weight ratio, add the carbomer in component B into water, and then add the remaining raw materials of component B after uniform dispersion, and then stir at 75-80° C. and 500-800 rpm for 30-60 minutes;

[0017] (2) Weigh all the raw materials of component A according to the weight ratio, and stir at 500-800 rpm for 30-60 min at 75-80°C;

[0018] (3) Add component B obtained in step (1) to component A obtained in step (2), stir at 75-80° C. and 1000-1500 rpm for 25-30 min, cool to 40-45° C. and reduce the speed to 500-800 rpm and continue stirring for 25-30 min, stop stirring, and return to room temperature to obtain the whitening skin care essence lotion.

[0019] The beneficial effects of the present invention are as follows: the present invention is compounded by DSPE-PEG and squalane. DSPE-PEG is a material with good biocompatibility and modification function. After being compounded with squalane, the resistance of active ingredients entering the skin is reduced, thereby significantly improving the skin permeability, so that ethyl ferulate can be more efficiently absorbed and utilized by the skin, and then better exert its skin care effect. The encapsulation structure formed by DSPE-PEG can form a physical encapsulation barrier, which can prevent ethyl ferulate from losing its activity due to oxidation and photolysis, thereby ensuring its stability during storage and use, and effectively reducing the loss of skin moisture through the epidermis, maintaining the moisture content of the skin at a high level, so that the skin remains hydrated, and creating favorable conditions for the penetration of ethyl ferulate active molecules. The skin care essence milk prepared by the present invention will not produce adverse stimulation to the skin while exerting the effects of whitening, anti-inflammatory, antioxidant and the like, and has the characteristics of small average particle size, uniform distribution and good stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The average particle size test results of each embodiment and comparative example of the present invention are shown in FIG.

[0021] Figure 2 The following are the results of skin permeation analysis of various embodiments and comparative examples of the present invention;

[0022] Figure 3 The antioxidant analysis results of various embodiments and comparative examples of the present invention are shown in FIG.

[0023] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0026] The experimental methods in the following examples are conventional methods unless otherwise specified, and the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0027] Example 1

[0028] A whitening skin care essence milk comprises a component A and a component B; the component A comprises the following components in parts by weight: 8 parts of dimethicone, 3 parts of capric triglyceride, 8 parts of ethyl ferulate-loaded nanoliposomes, 1 part of polydimethylsiloxane, 1 part of decamethylcyclopentasiloxane, 0.1 part of butylated hydroxyanisole, 1 part of sodium hyaluronate, 4 parts of niacinamide, 5 parts of arbutin, 5 parts of vitamin E acetate and 40 parts of water; the component B comprises the following components in parts by weight: 5 parts of betaine, 5 parts of glyceryl stearate, 0.5 part of carbomer and 0.1 part of triethanolamine.

[0029] The ethyl ferulate-loaded nanoliposomes are prepared by the following steps:

[0030] S1. Add squalane and DSPE-PEG to a mixed solution of N,N-dimethylformamide and triethylamine, wherein the mass ratio of squalane, DSPE-PEG, N,N-dimethylformamide and triethylamine is 1:4:40:1.5, add sodium hydroxide to adjust the pH to 8.5, and then stir at room temperature for 24 hours. The resulting solution is dialyzed with a 3.5 kD dialysis membrane for 72 hours, and then freeze-dried to obtain a squalane-DSPE-PEG complex;

[0031] S2. The squalane-DSPE-PEG complex and ethyl ferulate are heated to 100° C., the mass ratio of the squalane-DSPE-PEG complex and ethyl ferulate is 1:6, to obtain an oil phase, and deionized water and Tween-60 are mixed at a mass ratio of 20:1, and the mixture is stirred at 600 rpm for 30 min to obtain an aqueous phase, and the aqueous phase is quickly added to the oil phase, the mass ratio of the aqueous phase to the oil phase is 5:1, and the mixture is stirred at 600 rpm for 40 min to obtain the ethyl ferulate-loaded nanoliposomes.

[0032] The mass ratio of the component A to the component B is 5:1.

[0033] The DSPE-PEG is DSPE-PEG3400.

[0034] Example 2

[0035] A whitening skin care essence milk comprises a component A and a component B; the component A comprises the following components in parts by weight: 4 parts of dimethicone, 1 part of capric triglyceride, 3 parts of ethyl ferulate-loaded nanoliposomes, 0.5 parts of polydimethylsiloxane, 0.5 parts of decamethylcyclopentasiloxane, 0.05 parts of butylated hydroxyanisole, 0.5 parts of sodium hyaluronate, 2 parts of niacinamide, 3 parts of arbutin, 1 part of vitamin E acetate and 25 parts of water; the component B comprises the following components in parts by weight: 2 parts of betaine, 3 parts of glyceryl stearate, 0.1 parts of carbomer and 0.01 parts of triethanolamine.

[0036] The ethyl ferulate-loaded nanoliposomes are prepared by the following steps:

[0037] S1. Add squalane and DSPE-PEG to a mixed solution of N,N-dimethylformamide and triethylamine, wherein the mass ratio of squalane, DSPE-PEG, N,N-dimethylformamide and triethylamine is 1:2:20:0.5, add sodium hydroxide to adjust the pH to 8.5, and then stir at room temperature for 24 hours. The resulting solution is dialyzed with a 3.5 kD dialysis membrane for 36 hours, and then freeze-dried to obtain a squalane-DSPE-PEG complex;

[0038] S2. The squalane-DSPE-PEG complex and ethyl ferulate are heated to 80° C., the mass ratio of the squalane-DSPE-PEG complex and ethyl ferulate is 1:3, to obtain an oil phase, and then deionized water and Tween-60 are mixed in a mass ratio of 10:1, and the mixture is stirred at 400 rpm for 15 min to obtain an aqueous phase, and the aqueous phase is quickly added to the oil phase, the mass ratio of the aqueous phase to the oil phase is 3:1, and the mixture is stirred at 400 rpm for 20 min to obtain the ethyl ferulate-loaded nanoliposomes.

[0039] The mass ratio of the component A to the component B is 3:1.

[0040] The DSPE-PEG is DSPE-PEG1000.

[0041] Example 3

[0042] A whitening skin care essence milk comprises a component A and a component B; the component A comprises the following components in parts by weight: 6 parts of dimethicone, 2 parts of capric triglyceride, 5.5 parts of ethyl ferulate-loaded nanoliposomes, 0.75 parts of polydimethylsiloxane, 0.75 parts of decamethylcyclopentasiloxane, 0.075 parts of butylated hydroxyanisole, 0.75 parts of sodium hyaluronate, 3 parts of niacinamide, 4 parts of arbutin, 3 parts of vitamin E acetate and 32.5 parts of water; the component B comprises the following components in parts by weight: 3.5 parts of betaine, 4 parts of glyceryl stearate, 0.3 parts of carbomer and 0.055 parts of triethanolamine.

[0043] The ethyl ferulate-loaded nanoliposomes are prepared by the following steps:

[0044] S1. Add squalane and DSPE-PEG to a mixed solution of N,N-dimethylformamide and triethylamine, wherein the mass ratio of squalane, DSPE-PEG, N,N-dimethylformamide and triethylamine is 1:3:30:1, add sodium hydroxide to adjust the pH to 8.5, and then stir at room temperature for 24 hours. The resulting solution is dialyzed with a 3.5 kD dialysis membrane for 54 hours, and then freeze-dried to obtain a squalane-DSPE-PEG complex;

[0045] S2. The squalane-DSPE-PEG complex and ethyl ferulate are heated to 90° C., the mass ratio of the squalane-DSPE-PEG complex and ethyl ferulate is 1:4.5, to obtain an oil phase, and deionized water and Tween-60 are mixed at a mass ratio of 15:1, and the mixture is stirred at 500 rpm for 22.5 min to obtain an aqueous phase, and the aqueous phase is quickly added to the oil phase, the mass ratio of the aqueous phase to the oil phase is 4:1, and the mixture is stirred at 500 rpm for 30 min to obtain the ethyl ferulate-loaded nanoliposomes.

[0046] The mass ratio of the component A to the component B is 4:1.

[0047] The DSPE-PEG is DSPE-PEG2000.

[0048] Example 4

[0049] A method for preparing a whitening skin care essence lotion comprises the following steps:

[0050] (1) Weigh all the raw materials of component B according to the weight ratio, add the carbomer in component B into water, and then add the remaining raw materials of component B after uniform dispersion, and then stir at 75-80° C. and 500-800 rpm for 30-60 minutes;

[0051] (2) Weigh all the raw materials of component A according to the weight ratio, and stir at 500-800 rpm for 30-60 min at 75-80°C;

[0052] (3) Add component B obtained in step (1) to component A obtained in step (2), stir at 75-80° C. and 1000-1500 rpm for 25-30 min, cool to 40-45° C. and reduce the speed to 500-800 rpm and continue stirring for 25-30 min, stop stirring, and return to room temperature to obtain the whitening skin care essence lotion.

[0053] Comparative Example 1

[0054] In this comparative example, an equal amount of ethyl ferulate was used to replace the ethyl ferulate-loaded nanoliposomes, and the rest was the same as in Example 3.

[0055] Comparative Example 2

[0056] In this comparative example, an equal amount of DSPE-PEG was used to replace the squalane-DSPE-PEG complex, and the rest was the same as in Example 3.

[0057] Results Analysis

[0058] Test Example 1

[0059] Average particle size detection

[0060] The average particle size polarity of the nanoliposomes prepared in each embodiment and comparative example was detected by Zetasizer ULTRA nanoparticle size analyzer. The results are shown in Figure 1 .

[0061] Depend on Figure 1 It can be seen that the average particle size of the ethyl ferulate nanoliposomes in Examples 1-3 is relatively small and the distribution is relatively uniform. This is because when preparing the ethyl ferulate nanoliposomes, the squalane-DSPE-PEG complex forms a stable structure, and DSPE-PEG has good biocompatibility and modification functions. After it is compounded with squalane, the assembly and particle size of the liposomes can be better controlled in the process of forming nanoliposomes, so that the active ingredient ethyl ferulate can be evenly dispersed in the liposomes, thereby showing a smaller average particle size and uniform distribution.

[0062] Test Example 2

[0063] Transdermal performance analysis

[0064] The skin penetration rate was tested by soaking the cellulose acetate filter membranes of the essence milks of the embodiments of the present invention and the comparative examples. Figure 2 , the specific method is as follows:

[0065] (1) Fix the treated cellulose filter membrane between the supply tank and the receiving tank of the transdermal diffusion tester to ensure good sealing to prevent solution leakage;

[0066] (2) Add receiving medium to the receiving cell and place the receiving cell in a transdermal diffusion tester, set at 32° C. and stirring speed at 300 rpm;

[0067] (3) At intervals of 3, 6, 9, 12, 24, and 48 h, samples of the receiving medium were taken out of the receiving tank and an equal amount of fresh receiving medium was added to maintain a constant volume of the solution in the receiving tank.

[0068] (4) The essence milk content in the receiving medium sample was measured and the transdermal amount at different time points was calculated.

[0069] Depend on Figure 2 It can be seen that the transdermal rates of Examples 1-3 are significantly higher than those of Comparative Examples 1 and 2. This is because after the present invention combines DSPE-PEG with squalane, it exhibits many advantages in the transdermal process. First, the encapsulation structure formed by DSPE-PEG has unique physical and chemical properties, and the PEG chain segments on its surface have certain flexibility and hydrophilicity, which can interact with the lipid and protein components of the stratum corneum of the skin, and can change the structural arrangement of the stratum corneum of the skin, reduce its hindering effect on the active ingredients, and make it easier for the ethyl ferulate-loaded nanoliposomes to penetrate the stratum corneum of the skin and enter the deep layers of the skin. Squalane helps to enhance the affinity of the entire nanoliposome with the skin, promote its attachment and penetration on the skin surface, and create favorable conditions for the penetration of the active molecules of ethyl ferulate.

[0070] Test Example 3

[0071] Antioxidant performance analysis

[0072] According to TSHRH006-2018 "Cosmetics - Free Radical (DPPH) Scavenging Experimental Method", the antioxidant properties of the essence milk prepared in each embodiment and comparative example of the present invention were tested, and the results are shown in Figure 3 .

[0073] Depend on Figure 3It can be seen that the antioxidant performance of the essence milk prepared in each embodiment of the present invention is better than that of Comparative Example 1 and Comparative Example 2. In the ethyl ferulate nanoliposome, the encapsulation structure formed by DSPE-PEG plays a key protective role. The active groups such as phenolic hydroxyl groups in the molecular structure of ethyl ferulate are easily affected by oxidation and photolysis and lose activity. The encapsulation structure of DSPE-PEG can effectively isolate the oxidizing factors such as oxygen and light in the external environment. The physical encapsulation barrier formed by it seals the ethyl ferulate molecules inside the liposome, reduces the contact opportunity of ethyl ferulate with external oxidants and light, ensures the stability of ethyl ferulate during storage and use, enables it to continuously maintain antioxidant activity, and better play an antioxidant role.

[0074] Test Example 4

[0075] User experience evaluation

[0076] A questionnaire survey was conducted on 30 volunteers aged 20-40 years old after use, and the user experience was scored (out of 10 points). The results are shown in Table 1.

[0077] Table 1 Experience evaluation results

[0078] project Is there stimulation Description of the effect Scoring Example 1 No stimulation Lightens spots, whitens skin, moisturizes 10 Example 2 No stimulation Lightens spots, whitens skin, moisturizes 9.8 Example 3 No stimulation Lightens spots, whitens skin, moisturizes 10 Comparative Example 1 No stimulation Poor spot-lightening effect, average whitening effect, poor moisturizing effect 7.5 Comparative Example 2 No stimulation Average spot-lightening effect, average whitening effect, average moisturizing effect 8.5

[0079] As can be seen from Table 1, embodiment 1-3 is obviously better than comparative example 1 and comparative example 2 in use experience. Embodiment 1-3 has no stimulation and can make spots fade, skin whitening, moisturizing and skin-moistening effect is good, this is because the package structure formed by DSPE-PEG in the ethyl ferulate nanoliposome not only protects the activity of ethyl ferulate, but also has a positive contribution in skin moisturizing. The liposome structure formed by DSPE-PEG can form a layer of structure similar to a protective film on the skin surface, effectively reducing the loss of skin moisture through the epidermis, and its hydrophilic PEG segment can absorb and keep a certain amount of moisture, maintaining the moisture content of the skin at a higher level, making the skin keep a moist state, and at the same time, ethyl ferulate can play the skin care effects such as whitening, anti-inflammatory after being effectively absorbed by the skin. Ethyl ferulate can reduce the generation of melanin by suppressing the activity of tyrosinase, thereby reaching the effect of whitening and lightening spots.

[0080] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0081] The present invention and its implementation methods are described above, which is not restrictive. The drawings are only one of the implementation methods of the present invention, and the actual application is not limited thereto. In short, if ordinary technicians in the field are inspired by it and design methods and embodiments similar to the technical solution without creativity without departing from the purpose of the invention, they should all fall within the protection scope of the present invention.

Claims

1. A whitening skin care essence milk, comprising component A and component B, characterized in that: The component A comprises the following components in parts by weight: 4-8 parts of dimethicone, 1-3 parts of capric triglyceride, 3-8 parts of ethyl ferulate nanoliposomes, 0.5-1 parts of polydimethylsiloxane, 0.5-1 parts of decamethylcyclopentasiloxane, 0.05-0.1 parts of butylated hydroxyanisole, 0.5-1 parts of sodium hyaluronate, 2-4 parts of niacinamide, 3-5 parts of arbutin, 1-5 parts of vitamin E acetate and 25-40 parts of water; the component B comprises the following components in parts by weight: 2-5 parts of betaine, 3-5 parts of glyceryl stearate, 0.1-0.5 parts of carbomer and 0.01-0.1 parts of triethanolamine; The ethyl ferulate-loaded nanoliposomes are prepared by the following steps: S1, adding squalane and DSPE-PEG to a mixed solution of N,N-dimethylformamide and triethylamine, adding sodium hydroxide to adjust the pH to 8.5, then stirring at room temperature for 24 hours, dialyzing the resulting solution with a 3.5 kD dialysis membrane for 36-72 hours, and then freeze-drying to obtain a squalane-DSPE-PEG complex; S2. The squalane-DSPE-PEG complex and ethyl ferulate are heated to 80-100° C. to obtain an oil phase, and deionized water and Tween-60 are mixed and stirred at 400-600 rpm for 15-30 min to obtain an aqueous phase, and the aqueous phase is quickly added to the oil phase, and stirred at 400-600 rpm for 20-40 min to obtain the ethyl ferulate-loaded nanoliposomes.

2. The whitening skin care essence lotion according to claim 1, characterized in that: The mass ratio of component A to component B is 3-5:

1.

3. The whitening skin care essence lotion according to claim 2, characterized in that: In the step S1, the mass ratio of squalane, DSPE-PEG, N,N-dimethylformamide and triethylamine is 1:2-4:20-40:0.5-1.

5.

4. The whitening skin care essence lotion according to claim 3, characterized in that: In the step S2, the mass ratio of squalane-DSPE-PEG complex to ethyl ferulate is 1:3-6.

5. The whitening skin care essence lotion according to claim 4, characterized in that: The mass ratio of deionized water to Tween-60 in step S2 is 10-20:

1.

6. The whitening skin care essence lotion according to claim 5, characterized in that: The mass ratio of the water phase to the oil phase in step S2 is 3-5:

1.

7. The whitening skin care essence lotion according to claim 6, characterized in that: The DSPE-PEG is one of DSPE-PEG1000, DSPE-PEG2000 and DSPE-PEG3400.

8. A method for preparing the whitening skin care essence lotion according to any one of claims 1 to 7, characterized in that: The steps include: (1) Weigh all the raw materials of component B according to the weight ratio, add the carbomer in component B into water, and then add the remaining raw materials of component B after uniform dispersion, and then stir at 75-80° C. and 500-800 rpm for 30-60 minutes; (2) Weigh all the raw materials of component A according to the weight ratio, and stir at 500-800 rpm for 30-60 min at 75-80°C; (3) Add component B obtained in step (1) to component A obtained in step (2), stir at 75-80° C. and 1000-1500 rpm for 25-30 min, cool to 40-45° C. and reduce the speed to 500-800 rpm and continue stirring for 25-30 min, stop stirring, and return to room temperature to obtain the whitening skin care essence lotion.

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