A composition with moisturizing and repairing effects, preparation method and application thereof

Abstract

The present invention belongs to the technical field of cosmetics, and discloses a composition with moisturizing and repairing effects, a preparation method thereof and an application thereof. The composition of the present invention comprises a xylitol moisturizer, 4D hyaluronic acid, a peach resin extract and hydroxyphenyl propionamide benzoic acid, the xylitol moisturizer comprises at least one of xylitol, dehydrated xylitol and xylitol glucoside, and the 4D hyaluronic acid comprises at least one of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer. The present invention rationally compounds the xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenyl propionamide benzoic acid, can locate the skin at different layers, effectively increase the moisture content of the epidermis and dermis, and maintain the hydration state of the skin, while repairing damaged keratinocytes, enhancing the barrier function of the skin, and reducing the loss of water, thereby having good moisturizing and repairing effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a composition with moisturizing and repairing effects, a preparation method and application thereof. Background Art

[0002] Among cosmetics with various functions, moisturizing function is the most basic and the most important, because skin with full moisture is the premise for other active ingredients to penetrate deep into the skin, so moisturizing is necessary at all times. In addition, the integrity of the skin barrier can maximize the moisturizing effect. Repairing the skin's barrier function can complement the skin's moisturizing to a certain extent, and obtain a more ideal product use effect. Therefore, it is particularly important to develop a product that has both moisturizing and repairing effects. Summary of the invention

[0003] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a composition with moisturizing and repairing effects, and a preparation method and application thereof. The composition provided by the present invention can effectively increase the moisture content of the epidermis and dermis, and maintain the hydration of the skin, while repairing damaged keratinocytes, enhancing the barrier function of the skin, and reducing the loss of water, thereby having a good moisturizing and repairing effect.

[0004] The first aspect of the present invention provides a composition, which includes a xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenyl propionamide benzoic acid, wherein the xylitol moisturizer includes at least one of xylitol, dehydrated xylitol and xylitol glucoside, and the 4D hyaluronic acid includes at least one of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.

[0005] In some embodiments of the present invention, the composition comprises, by weight, 1-35 parts of xylitol moisturizer, 1-30 parts of 4D hyaluronic acid, 1-35 parts of peach resin extract and 0.1-5 parts of hydroxyphenylpropionamide benzoic acid.

[0006] In some embodiments of the present invention, the composition comprises, by weight, 1-30 parts of xylitol moisturizer, 1-25 parts of 4D hyaluronic acid, 1-30 parts of peach resin extract, and 0.5-5 parts of hydroxyphenylpropionamide benzoic acid.

[0007] In some embodiments of the present invention, the composition comprises, by weight, 5-28 parts of xylitol moisturizer, 3-20 parts of 4D hyaluronic acid, 5-28 parts of peach resin extract and 1-5 parts of hydroxyphenylpropionamide benzoic acid.

[0008] In some embodiments of the present invention, the xylitol humectant includes xylitol, anhydroxylitol and xylitol glucoside.

[0009] In some embodiments of the present invention, the 4D hyaluronic acid includes sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.

[0010] In some embodiments of the present invention, the composition further comprises a polyol.

[0011] In some embodiments of the present invention, the polyol comprises butanediol and / or 1,2-hexanediol.

[0012] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0013] The xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenylpropionamide benzoic acid are mixed to obtain the composition.

[0014] The third aspect of the present invention provides a cosmetic comprising the composition according to the first aspect of the present invention.

[0015] In some embodiments of the present invention, the content of the composition in the cosmetic is 1wt-20wt%.

[0016] In some embodiments of the present invention, the content of the composition in the cosmetic is 5wt-15wt%.

[0017] In some embodiments of the present invention, the dosage form of the cosmetic includes any one of an aqueous solution, an emulsion, a spray, a cream, an essence or a mask.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0019] (1) The present invention rationally compounds xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenylpropionamide benzoic acid, which can locate the skin at different layers, effectively increase the moisture content of the epidermis and dermis, and maintain the hydration of the skin, while repairing damaged keratinocytes, enhancing the barrier function of the skin, and reducing the loss of water, thereby having a good moisturizing and repairing effect.

[0020] (2) The present invention combines multiple active ingredients to solve the problem of incomplete target sites of a single ingredient. The components in the composition of the present invention can play a synergistic role to achieve good moisturizing and repairing effects. At the same time, it is mild and non-irritating, which makes it have broad application prospects in the development of cosmetics. DETAILED DESCRIPTION

[0021] The present invention is further described in detail below by specific examples. The raw materials, reagents or devices used in the examples can be obtained from conventional commercial sources or by prior art methods unless otherwise specified. Unless otherwise specified, the experiments or test methods are conventional methods in the art.

[0022] The sources of raw materials used in the present invention are as follows:

[0023] Xylitol moisturizer, trade name: AQUAXYL TM Xylitol moisturizer, manufacturer: SEPPIC SA.

[0024] Specifically, AQUAXYL TM Xylitol moisturizer is derived from natural plants. It can moisturize and rebuild the skin structure system, promote the increase of hyaluronic acid and chondroitin sulfate content, increase the moisture content of the epidermis and dermis, promote the synthesis of ceramide, enhance the skin's barrier function, improve skin structure, and reduce water loss.

[0025] 4D hyaluronic acid, product name: Hymagic TM -4D 4D hyaluronic acid, manufacturer: Bloomage Biotech Co., Ltd.

[0026] Specifically, Hymagic TM -4D 4D hyaluronic acid builds a three-dimensional water storage sponge layer, accurately positioning the skin at different layers, achieving the effect of outer layer hydration, inner layer water locking, and moisturizing layer by layer, making the skin moisturized and shiny from the inside out. In addition, the acetylated sodium hyaluronate enhances its affinity and adsorption to the stratum corneum, which can reduce water evaporation on the skin surface and increase internal water accumulation, and can penetrate the epidermis to hydrate and soften the stratum corneum, repair damaged keratin cells, and play a dual moisturizing and efficient repair effect.

[0027] Peach resin extract, trade name: Amber NP, manufacturer: Miaosen Co., Ltd.

[0028] Specifically, peach resin extract can effectively increase and maintain the moisture content of the skin, smooth skin scales caused by dryness, and reduce the roughness of dry skin, with excellent moisturizing effects.

[0029] Hydroxyphenylpropionamide benzoic acid, trade name: Manufacturer: Dezhixin Flavors and Fragrances (Nantong) Co., Ltd.

[0030] Specifically, hydroxyphenylpropionamide benzoic acid can effectively reduce skin redness, swelling and itching, reduce skin damage induced by free radicals, minimize the cascade reaction of skin inflammation, and soothe sensory nerves.

[0031] Example 1

[0032] A composition, consisting of the following components in percentage by weight:

[0033] Butylene glycol 40.0%, xylitol humectant 20.0%, 4D hyaluronic acid 15.0%, peach resin extract 20.0%, hydroxyphenyl propionamide benzoic acid 3.0% and 1,2-hexanediol 2.0%.

[0034] The composition is prepared by uniformly mixing butylene glycol, xylitol moisturizer, 4D hyaluronic acid, peach resin extract, hydroxyphenylpropionamide benzoic acid and 1,2-hexanediol.

[0035] Example 2

[0036] A composition, consisting of the following components in percentage by weight:

[0037] Butylene glycol 36.0%, xylitol humectant 25.0%, 4D hyaluronic acid 20.0%, peach resin extract 15.0%, hydroxyphenyl propionamide benzoic acid 2.0% and 1,2-hexanediol 2.0%.

[0038] The composition is prepared by uniformly mixing butylene glycol, xylitol moisturizer, 4D hyaluronic acid, peach resin extract, hydroxyphenylpropionamide benzoic acid and 1,2-hexanediol.

[0039] Example 3

[0040] A composition, consisting of the following components in percentage by weight:

[0041] Butylene glycol 37.0%, xylitol humectant 15.0%, 4D hyaluronic acid 20.0%, peach resin extract 25.0%, hydroxyphenyl propionamide benzoic acid 1.0% and 1,2-hexanediol 2.0%.

[0042] The composition is prepared by uniformly mixing butylene glycol, xylitol moisturizer, 4D hyaluronic acid, peach resin extract, hydroxyphenylpropionamide benzoic acid and 1,2-hexanediol.

[0043] Comparative Example 1

[0044] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not contain xylitol moisturizer, 4D hyaluronic acid, peach resin extract, and hydroxyphenylpropionamide benzoic acid, and the composition consists of the following components in weight percentage: 98.0% butanediol and 2.0% 1,2-hexanediol.

[0045] Comparative Example 2

[0046] The difference between Comparative Example 2 and Example 1 is that the composition of Comparative Example 2 does not contain xylitol moisturizer, and the composition consists of the following components in weight percentage: 60.0% butylene glycol, 15.0% 4D hyaluronic acid, 20.0% peach resin extract, 3.0% hydroxyphenylpropionamide benzoic acid, and 2.0% 1,2-hexanediol.

[0047] Comparative Example 3

[0048] The difference between Comparative Example 3 and Example 1 is that the composition of Comparative Example 3 does not contain 4D hyaluronic acid, and the composition is composed of the following components in weight percentage: 55.0% butylene glycol, 20.0% xylitol moisturizer, 20.0% peach resin extract, 3.0% hydroxyphenylpropionamide benzoic acid, and 2.0% 1,2-hexanediol.

[0049] Comparative Example 4

[0050] The difference between Comparative Example 4 and Example 1 is that the composition of Comparative Example 4 does not contain peach resin extract, and the composition is composed of the following components in weight percentage: 60.0% of butylene glycol, 20.0% of xylitol moisturizer, 15.0% of 4D hyaluronic acid, 3.0% of hydroxyphenylpropionamide benzoic acid, and 2.0% of 1,2-hexanediol.

[0051] Comparative Example 5

[0052] The difference between Comparative Example 5 and Example 1 is that the composition of Comparative Example 5 does not contain hydroxyphenylpropionamide benzoic acid, and the composition consists of the following components in weight percentage: 43.0% butylene glycol, 20.0% xylitol moisturizer, 15.0% 4D hyaluronic acid, 20.0% peach resin extract, and 2.0% 1,2-hexanediol.

[0053] Comparative Example 6

[0054] The difference between Comparative Example 6 and Example 1 is that the active ingredient of the composition of Comparative Example 6 contains only xylitol moisturizer, and the composition is composed of the following components in weight percentage: 78.0% butanediol, 20.0% xylitol moisturizer, and 2.0% 1,2-hexanediol.

[0055] Comparative Example 7

[0056] The difference between Comparative Example 7 and Example 1 is that the active ingredient of the composition of Comparative Example 7 contains only 4D hyaluronic acid, and the composition is composed of the following components in weight percentage: 83.0% butanediol, 15.0% 4D hyaluronic acid, and 2.0% 1,2-hexanediol.

[0057] Comparative Example 8

[0058] The difference between Comparative Example 8 and Example 1 is that the active ingredient of the composition of Comparative Example 8 contains only peach resin extract, and the composition is composed of the following components in weight percentage: 78.0% butanediol, 20.0% peach resin extract, and 2.0% 1,2-hexanediol.

[0059] Comparative Example 9

[0060] The difference between Comparative Example 9 and Example 1 is that the active ingredient of the composition of Comparative Example 9 contains only hydroxyphenylpropionamide benzoic acid, and the composition is composed of the following components in weight percentage: 95.0% butanediol, 3.0% hydroxyphenylpropionamide benzoic acid, and 2.0% 1,2-hexanediol.

[0061] Comparative Example 10

[0062] The difference between Comparative Example 10 and Example 1 is that tetrahydromethylpyrimidine carboxylic acid is used to replace hydroxyphenylpropionamide benzoic acid in the composition of Comparative Example 10, and the composition consists of the following components in weight percentage: 40.0% of butylene glycol, 20.0% of xylitol moisturizer, 15.0% of 4D hyaluronic acid, 20.0% of peach resin extract, 3.0% of tetrahydromethylpyrimidine carboxylic acid, and 2.0% of 1,2-hexanediol.

[0063] Comparative Example 11

[0064] The difference between Comparative Example 11 and Example 1 is that in the composition of Comparative Example 10, dipotassium glycyrrhizinate is used to replace hydroxyphenylpropionamide benzoic acid, and the composition consists of the following components in weight percentage: 40.0% butylene glycol, 20.0% xylitol moisturizer, 15.0% 4D hyaluronic acid, 20.0% peach resin extract, 3.0% dipotassium glycyrrhizinate, and 2.0% 1,2-hexanediol.

[0065] Application Examples 1-3

[0066] Application Examples 1-3 respectively provide an essence water containing the composition of the present invention, and the specific formula is shown in Table 1, and the unit is weight percentage.

[0067] Table 1

[0068]

[0069]

[0070] The method for preparing the essence water of application examples 1-3 comprises the following steps:

[0071] (1) Heat the raw materials of phase A to 80-85°C, stir and disperse evenly, and set aside;

[0072] (2) Heat the phase B raw material to 65-70°C and stir to dissolve evenly;

[0073] (3) Pour the raw materials of phase B into phase A for homogenization and stirring, and then cool down after stirring evenly;

[0074] (4) After cooling to 45°C, add the raw materials of phase C and stir to disperse evenly to obtain essence water.

[0075] Application Comparative Examples 1-11

[0076] The difference between applying comparative examples 1-11 and applying example 1 is that, in applying comparative examples 1-11, the composition of example 1 is replaced by the composition of comparative examples 1-11 in equal amounts, for example, in applying comparative example 1, the composition of example 1 is replaced by the composition of comparative example 1 in equal amounts, and in applying comparative example 2, the composition of example 1 is replaced by the composition of comparative example 2 in equal amounts, and so on.

[0077] Test Example 1 Stability Evaluation

[0078] Experimental methods:

[0079] High and low temperature stability: 100g of essence water sample was placed in a transparent PET bottle and placed at 5℃, 25℃ and 40℃ respectively. After 30 days, it was taken out and restored to room temperature to observe its status and record the situation.

[0080] In addition, the present invention also conducts a temperature cycle test of -15°C to 5°C to 48°C, wherein the sample in the transparent PET bottle is first placed in a -15°C refrigerator for 48 hours, taken out and placed in a 5°C refrigerator for 48 hours, taken out again and placed in a 48°C oven for 48 hours, completing one cycle. The above operation is repeated 5 times, that is, after 30 days, the sample is taken out and restored to room temperature to observe the state of the sample and record the situation.

[0081] Result analysis: If the state of the sample taken out after 30 days and restored to room temperature is not significantly different from that before the test, it means that it has passed the high and low temperature stability test, otherwise it cannot pass the high and low temperature stability test.

[0082] The test results are shown in Table 2 below.

[0083] Table 2

[0084]

[0085]

[0086]

[0087] It can be seen from the test results in Table 2 that the samples of the application examples and the comparative examples all passed the stability test, indicating that the composition of the present invention has good stability when used in cosmetics, which is also the basis for the composition of the present invention to be widely used in cosmetics development.

[0088] Test Example 2 Safety Evaluation

[0089] Tested substances: the essence water of application examples 1-3 and application comparative examples 1-11.

[0090] Volunteer selection: Healthy female volunteers aged 20-35 years old, voluntarily participated in and completed the experiment as required, and signed the informed consent. All experimental conditions that were not suitable for this test were excluded. A total of 420 people were included, 30 in each group.

[0091] Experimental method: After cleansing every night, volunteers apply an appropriate amount of the product to the test side (randomly divide the facial skin on both sides into the test side and the blank control side, the test side uses the product, and the blank control side does not use any product). Gently massage with fingertips, and then press gently to promote product absorption. Use once every night, the test cycle is 12 weeks, and there are 5 follow-up visits before the study (Day 0), 1 week, 4 weeks, 8 weeks and 12 weeks after using the product. The researchers carefully observe the skin condition of the test side of the subjects and record it. All adverse skin reactions such as skin redness, stinging, itching, burning, etc. that occur during the period should be recorded, and if there are serious adverse reactions, the subjects should report them in time.

[0092] Result analysis: The classification of skin adverse reactions is determined according to the classification of skin adverse reactions in human trial tests specified in the 2015 edition of the "Technical Specifications for Safety of Cosmetics" issued by the State Food and Drug Administration:

[0093] Grade 0 (no skin reaction); Grade 1 (light erythema on the skin); Grade 2 (erythema, infiltration and papules on the skin); Grade 3 (erythema, edema, papules and blisters on the skin); Grade 4 (erythema, edema and bullae on the skin).

[0094] The test results are shown in Table 3 below.

[0095] Table 3

[0096]

[0097]

[0098] From the results in Table 3, within the 12-week test period, no adverse reactions were recorded when using the essence water of Application Examples 1-3, indicating that the essence water of Application Examples 1-3 is safe, while the compositions of Application Comparative Example 1 and Application Comparative Examples 5-8 do not contain hydroxyphenylpropionamide benzoic acid, and all have adverse reactions, indicating that the addition of hydroxyphenylpropionamide benzoic acid enhances the mildness of the composition of the present invention to a certain extent, and can effectively relieve the discomfort that occurs during the use of consumers. In addition, the hydroxyphenylpropionamide benzoic acid in the composition of the present invention is replaced with tetrahydromethylpyrimidine carboxylic acid and dipotassium glycyrrhizinate. From the test results, Application Comparative Example 10 and Application Comparative Example 11 both have Grade 1 adverse reactions after replacement, indicating that the synergistic effect of hydroxyphenylpropionamide benzoic acid on the mildness of the composition of the present invention is better than that of tetrahydromethylpyrimidine carboxylic acid and dipotassium glycyrrhizinate.

[0099] Test Example 3 Patch test

[0100] Tested substances: the essence water of application examples 1-3 and application comparative examples 1-11.

[0101] Subjects: Healthy female volunteers aged 20-35 years old, who voluntarily participated in and completed the test as required and signed the informed consent. All experimental conditions that were not suitable for this test were excluded. A total of 30 people were included, and each of them tested the above 14 groups of samples.

[0102] Test method: Use a syringe to take 0.03 mL of sample and place it in the chamber of the spot test tape. Immediately apply the spot test tape with the sample to the normal skin of the left forearm from the bottom, and press the chambers lightly to expel air and evenly distribute the test substance. Mark the test site for easy observation. The blank control group is for the subjects who do not use the sample.

[0103] Result analysis: After 24 hours, the patch test tape was removed, and the skin reaction was observed after half an hour, 24 hours, and 48 hours. The results of the skin reaction were recorded and analyzed according to the CTFA guidelines.

[0104] The identification criteria for skin irritation test are shown in Table 4.

[0105] Table 4

[0106] grade symbol Identification criteria 0 - Negative reaction: no irritation, no erythema 1 ± Suspected reaction: Mild erythema 2 + Weak positive reaction: erythema 3 ++ Strong positive reaction: erythema, papules, blisters 4 +++ Very strong positive reaction: severe edema, large blisters

[0107] The test results are shown in Table 5.

[0108] Table 5

[0109]

[0110]

[0111]

[0112] From the results in Table 5, it can be seen that among the volunteers tested, there were no adverse reactions when using the essence water of application examples 1-3, indicating that the application of the composition of the present invention in the essence water is mild and safe, while the application of the essence water of comparative examples 1-11 all showed irritation reactions to varying degrees, indicating that the xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenylpropionamide benzoic acid in the composition of the present invention are reasonably compounded to improve the mildness of the composition.

[0113] Test Example 4 Moisturizing Efficacy Test

[0114] Tested substances: the essence water of application examples 1-3 and application comparative examples 1-11.

[0115] Subjects: Healthy people aged 18-35 years old, who voluntarily participated and were able to complete the test as required, maintained a regular lifestyle, avoided ultraviolet radiation, and did not use anti-allergic drugs during the entire trial observation period, and signed an informed consent form. Excluding all experimental conditions that were not suitable for this test, a total of 420 people were included, with 30 people in each group.

[0116] Test method: After cleansing the skin every morning and evening, volunteers apply an appropriate amount of the sample to the facial skin, gently massage with the fingertips, and then press lightly to promote product absorption. The test period is 7 days. Before use (D0) and on the seventh day after use (D7), at a temperature of 21±1℃ and a humidity of 50±10%, the volunteers clean their faces and wait for 20 minutes before testing the moisture content of the facial skin to comprehensively evaluate the moisturizing effect of the essence water in the present invention on human skin.

[0117] Result analysis: The change rate of skin moisture content after using the test product compared with that before use was recorded. A positive value indicates an increase in moisture content and an increase in skin moisture, while a negative value indicates a decrease in moisture content and a decrease in skin moisture. The Shapiro-Wilk Test was used to test the significance of the normal distribution of the improvement values ​​before use (D0) and on the seventh day (D7). If the data showed a normal distribution, a paired t test was performed, and the significant difference level α was 0.05; if the data showed a non-normal distribution, a Wilcoxon test was performed, and the significant difference level α was 0.05. If the change results of the moisture content of any skin stratum corneum before and after the use of the product were significantly improved (P < 0.05), the product was deemed to have a moisturizing effect, otherwise the product was deemed to have no moisturizing effect.

[0118] The test results are shown in Table 6.

[0119] Table 6

[0120]

[0121]

[0122] From the results in Table 6, after using the essence water of application examples 1-3 for 7 days, the moisture content of the skin is significantly improved, which is better than the results of the essence water of application examples 1-11, indicating that the xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenyl propionamide benzoic acid in the composition of the present invention can more effectively replenish skin moisture after reasonable compounding, and the moisturizing effect without any one of the ingredients cannot achieve the effect of the present invention. Even if the results of application examples 5, 10, and 11 show significant differences, the improvement of skin moisture content is not as good as the essence water of application examples 1-3. In general, the composition composed of the four active ingredients of xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenyl propionamide benzoic acid selected by the present invention has a synergistic effect and can significantly improve the moisturizing effect.

[0123] Test Example 5 Repair Efficacy Test

[0124] Tested substances: the essence water of application examples 1-3 and application comparative examples 1-11.

[0125] Subjects: Healthy people aged 18-35 years old, who voluntarily participated and were able to complete the test as required, maintained a regular lifestyle, avoided ultraviolet radiation, and did not use anti-allergic drugs during the entire trial observation period, and signed an informed consent form. Excluding all experimental conditions that were not suitable for this test, a total of 420 people were included, with 30 people in each group.

[0126] Test method: After cleansing the skin every morning and evening, volunteers apply an appropriate amount of sample to the facial skin, gently massage with fingertips, and then press lightly to promote product absorption. The test period is 7 days. Before use (D0) and on the seventh day after use (D7), at a temperature of 21±1℃ and a humidity of 50±10%, volunteers clean their faces and wait for 20 minutes before testing the transepidermal water loss (TEWL value) of the facial skin to comprehensively evaluate the repair effect of the essence water in the present invention on human skin.

[0127] Result analysis: The change rate of skin water loss rate after using the test product was recorded compared with that before use. A positive value indicates that the skin water loss rate increases and the skin barrier function weakens, while a negative value indicates that the skin water loss rate decreases and the skin barrier function strengthens. The Shapiro-Wilk Test was used to test the significance of the normal distribution of the improvement values ​​before use (D0) and on the seventh day (D7). If the data showed a normal distribution, a paired t test was performed, and the significant difference level α was 0.05; if the data showed a non-normal distribution, a Wilcoxon test was performed, and the significant difference level α was 0.05. If the change results of any transepidermal water loss rate before and after the use of the product were significantly improved (P < 0.05), the product was deemed to have a repair effect, otherwise the product was deemed to have no repair effect.

[0128] The test results are shown in Table 7.

[0129] Table 7

[0130]

[0131]

[0132] From the results of Table 7, after using the samples of Application Examples 1-3 for 7 days, the transepidermal water loss (TEWL) was significantly reduced, while there was no significant difference in the TEWL changes of Application Comparative Examples 1-11, indicating that the composition composed of the four active ingredients of xylitol moisturizer, 4D hyaluronic acid, peach resin extract, and hydroxyphenyl propionamide benzoic acid selected in the present invention has a repair effect and can effectively reduce the transepidermal water loss. The repair effect of the lack of any one of the ingredients is affected; at the same time, from the data results of Application Example 1 and Application Comparative Examples 10 and 11, replacing the hydroxyphenyl propionamide benzoic acid in the composition also has a more obvious effect on the repair effect of the composition; in addition, from the results of Application Examples 1-3, it can be seen that adjusting the proportion of the active ingredients in the composition has an effect on the repair effect of the composition, among which Application Example 1 has the most obvious effect on reducing the transepidermal water loss. In general, the composition composed of the four active ingredients of xylitol moisturizer, 4D hyaluronic acid, peach resin extract, and hydroxyphenyl propionamide benzoic acid selected in the present invention has a synergistic effect and can significantly improve the repair effect.

[0133] Test Example 6 Sensory Evaluation Test

[0134] Tested substances: the essence water of application examples 1-3 and application comparative examples 1-11.

[0135] Subjects: Healthy female volunteers aged 20-35 years old, who voluntarily participated in and completed the experiment as required and signed the informed consent. All experimental conditions that were not suitable for this test were excluded. A total of 420 people were included, 30 people in each group.

[0136] Test method: After cleansing every morning and evening, volunteers apply an appropriate amount of the product to the facial skin, gently massage with the fingertips, and then gently press to promote product absorption. Use once a day in the morning and evening, and the test cycle is 7 days. A single-blind method is used. After the test cycle, volunteers evaluate the skin condition after using the product through a questionnaire and analyze the product's use effect.

[0137] Result analysis: If the efficiency of the evaluation dimension is greater than or equal to 50%, the product is considered effective. Efficiency = (obvious + very obvious) / total number of people × 100%.

[0138] Among them, obvious and very obvious are the evaluations made by volunteers after trying the product. The evaluation questionnaire has four dimensions: very unobvious, unobvious, obvious, and very obvious. Volunteers evaluated their actual feelings after using the product. The result analysis directly selected and summarized the data that believed the product was effective.

[0139] The summary results of the effective rate are shown in Table 8.

[0140] Table 8

[0141]

[0142] From the results of Table 8, the consumer evaluation of the essence water using the application examples 1-3 is better than that using the essence water using the application comparative examples 1-11, indicating that the composition composed of the four active ingredients of xylitol moisturizing agent, 4D hyaluronic acid, peach resin extract, and hydroxyphenyl propionamide benzoic acid selected by the present invention can give consumers a better product experience during use, which is an important indicator of the composition in cosmetic applications. A good product experience can make the product more widely accepted by consumers, which also promotes the promotion of the composition of the present invention to a certain extent, so that it can be more widely used. In general, the present invention compounds xylitol moisturizing agent, 4D hyaluronic acid, peach resin extract, and hydroxyphenyl propionamide benzoic acid, which can give consumers a better use experience while ensuring the product efficacy.

[0143] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, characterized in that The composition comprises a xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenyl propionamide benzoic acid, wherein the xylitol moisturizer comprises at least one of xylitol, dehydrated xylitol and xylitol glucoside, and the 4D hyaluronic acid comprises at least one of sodium hyaluronate, hydrolyzed sodium hyaluronate, acetylated sodium hyaluronate and sodium hyaluronate cross-linked polymer.

2. The composition according to claim 1, characterized in that Calculated by weight, the composition comprises 1-35 parts of xylitol moisturizer, 1-30 parts of 4D hyaluronic acid, 1-35 parts of peach resin extract and 0.1-5 parts of hydroxyphenylpropionamide benzoic acid.

3. The composition according to claim 2, characterized in that Calculated by weight, the composition comprises 1-30 parts of xylitol moisturizer, 1-25 parts of 4D hyaluronic acid, 1-30 parts of peach resin extract and 0.5-5 parts of hydroxyphenylpropionamide benzoic acid.

4. The composition according to claim 3, characterized in that Calculated by weight, the composition comprises 5-28 parts of xylitol moisturizer, 3-20 parts of 4D hyaluronic acid, 5-28 parts of peach resin extract and 1-5 parts of hydroxyphenylpropionamide benzoic acid.

5. The composition according to claim 1, characterized in that The composition also includes a polyol.

6. A method for preparing the composition according to any one of claims 1 to 5, characterized in that: The following steps are involved: The xylitol moisturizer, 4D hyaluronic acid, peach resin extract and hydroxyphenylpropionamide benzoic acid are mixed to obtain the composition.

7. A cosmetic, characterized in that: The cosmetic comprises the composition according to any one of claims 1 to 5.

8. The cosmetic according to claim 7, characterized in that: The content of the composition is 1wt-20wt%.

9. The cosmetic according to claim 8, characterized in that: The content of the composition is 5wt-15wt%.

10. The cosmetic according to claim 7, characterized in that: The dosage form of the cosmetic includes any one of an aqueous solution, an emulsion, a spray, a cream, an essence or a facial mask.

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