Composition for relieving sensitive skin itch and improving barrier and application

Abstract

The invention discloses a composition for relieving sensitive skin itch and improving a barrier and application, and relates to the technical field of cosmetics. The composition comprises a component A and a component B, the component A comprises a flaxseed extract and a roxburgh rose fruit extract; and the component B comprises an annona squamosa extract and a thlaspi arvense extract. The flaxseed extract, the rosa roxburghii tratt fruit extract, the annona squamosa extract and the thlaspi arvense extract are combined to find that the composition has a synergistic interaction effect, and the composition formed by specific compatibility has the effects of improving facial itching of sensitive skin, reducing excessive activation of neurons and inhibiting inflammation; the effects of repairing an objective barrier and replenishing water and preserving moisture are achieved.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a composition for relieving itching of sensitive skin and improving barrier function and application thereof. Background Art

[0002] Sensitive skin refers to a type of skin that shows an abnormally strong reaction to external stimuli (such as temperature changes, chemicals, friction, pressure, etc.). It usually manifests as irritating erythema, itching, burning or tingling. Among them, erythema, burning and tingling are the most easily discovered and most concerned symptoms, while people pay less attention to facial itching. Because compared with other symptoms, the irritation source of itching is often smaller and more difficult to determine, which makes it more difficult to predict and solve. In many cases, the reaction to itching may be more complicated, including physiological triggers, and is closely related to psychological and emotional factors. The feeling of itching usually lasts for a long time, while redness, swelling, tingling and burning often disappear as the injury disappears. Long-term itching can cause people's anxiety and uneasiness, affecting their mood and sleep quality. At the same time, the stimulation of itching can trigger the body's defense response, such as releasing chemicals such as histamine, which can further increase the degree of itching and cause skin inflammation. People usually respond to itching by scratching, but repeated scratching may cause skin desquamation and damage, aggravate secondary stimulation, and form a vicious circle. So, this is what people usually say, "Pain can be tolerated, but itching cannot."

[0003] The pruritus problem of sensitive skin is the result of the combined effects of multiple factors, including (1) impaired skin barrier function. Sensitive skin is usually accompanied by a weak epidermal stratum corneum, which makes the skin more susceptible to moisture loss, leading to dryness and itching; (2) increased neurosensitivity, including overactivation of neurons and release of neurotransmitters, such as the release of calcitonin gene-related peptide (CGRP), which enhances pain and itch perception, and can also trigger local inflammation and promote the release of pro-inflammatory factors; (3) inflammatory response, the activation of inflammatory cells and the release of cytokines can cause pruritus, such as mast cell degranulation and the release of pro-inflammatory amines; (4) external chemicals and certain skin care products can cause irritation and itch; (5) stress and anxiety may further aggravate the pruritus by activating the skin's neural mechanisms. Therefore, improving the pruritus problem of sensitive skin requires barrier repair, replenishing skin moisture and lipids, reducing overactivation of neurons and inflammatory response, and relieving stress and anxiety.

[0004] Currently, most products on the market prioritize analgesia and redness relief. There are few products specifically targeting itching of sensitive skin, and no product can comprehensively improve itching from the above five aspects. Summary of the invention

[0005] Based on this, the purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide a composition and application for relieving itching of sensitive skin and improving the barrier.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides a composition for relieving itching of sensitive skin and improving the barrier, the composition comprising component A and component B; component A comprises flaxseed extract and roxburghii fruit extract; component B comprises cherimoya extract and pennywort extract.

[0008] Flaxseed extract is rich in omega-3 fatty acids, antioxidants and phytoestrogens, which can effectively moisturize and repair the skin. It has anti-inflammatory properties, can reduce skin irritation and improve inflammatory symptoms, and can also enhance the skin's moisturizing ability by enhancing the function of lamellar bodies, promoting tight junctions and barrier repair of keratinocytes. In addition, flaxseed extract can also resist oxidation, resist environmental stress, help slow down skin aging, and make the skin smoother and younger. At the same time, it helps to improve skin tone and make the skin brighter and more even.

[0009] Rosa roxburghii fruit extract is rich in vitamin C and polyphenols, and has significant skin care effects. Its powerful antioxidant properties can effectively neutralize free radicals, slow down skin aging, and promote collagen synthesis to improve skin elasticity. In addition, Rosa roxburghii fruit extract has a good moisturizing effect, which can improve the moisture content of the skin and make the skin more moisturized and smooth. At the same time, its anti-inflammatory properties help relieve skin irritation, restore the skin to a healthy state, and show a natural glow.

[0010] The extract of cherimoya has a significant effect on improving skin itching, mainly by inhibiting calcitonin gene-related peptide (CGRP) and promoting the synthesis of β-endorphin. CGRP plays an important role in causing itching and inflammatory reactions. The inhibitory effect of the extract can effectively reduce itching and discomfort, while alleviating the inflammatory response of the skin. On the other hand, β-endorphin is known as a "natural analgesic". Its promotion helps to improve the comfort of the skin, relieve the discomfort caused by itching, enable the skin to be better repaired and balanced, and improve overall health.

[0011] Selenops extract is rich in selenopolysaccharide, a polysaccharide complex with selenium. This ingredient has powerful anti-inflammatory and antioxidant properties, which can relieve itching caused by allergies or inflammation. Selenopsaccharide can reduce itching symptoms by regulating the skin's immune response and inhibiting the release of inflammatory mediators. At the same time, it can moisturize and repair damaged skin barriers, enhance the skin's moisturizing ability, further reduce the discomfort of dryness and itching, and promote skin health and comfort.

[0012] The present invention has found that when the above-mentioned plant extracts are used in combination, they can synergistically improve facial itching in people with sensitive skin, reduce excessive neuronal activation and inhibit inflammation, as well as repair the objective barrier and replenish moisture, and have the effects of relieving itching, calming, soothing and smoothing the skin.

[0013] As a preferred embodiment of the first aspect, the mass ratio of component A to component B in the composition is component A:component B=(0.6-3):(0.02-1.5).

[0014] Exemplarily, the mass ratio of component A and component B can be any point value between (0.6-3):(0.02-1.5) or a range value between any two points, such as 0.6:0.02, 0.6:0.05, 0.6:0.1, 0.6:0.5, 0.6:1, 0.6:1.5, 1:0.02, 1:1, 1:1.5, 2:0.02, 2:0.1, 2:0.5, 2:1, 2:1.5, 3:0.02, 3:0.1, 3:0.5, 3:1, 3:1.5.

[0015] As a preferred embodiment of the first aspect, the mass ratio of component A to component B in the composition is component A:component B=(1.2-2.3):(0.2-0.7).

[0016] As a preferred embodiment of the first aspect, the mass ratio of component A to component B in the composition is component A:component B=1.6:0.4.

[0017] The present invention has found that the mass ratio of component A and component B in the composition for relieving sensitive skin itching and improving the barrier will affect the effect of inhibiting excessive neuronal activation and inflammation to a certain extent, thereby affecting the efficacy of the composition in improving itching. At the same time, it will also affect the objective barrier repair and moisturizing efficacy of the composition. When the mass ratio of component A and component B is further selected as (0.6-3): (0.02-1.5), especially (1.2-2.3): (0.2-0.7), the obtained composition for relieving sensitive skin itching and improving the barrier has better antipruritic and anti-inflammatory effects; and can enhance the inhibitory effect of the composition on calcitonin gene-related peptide and IL-33 to a greater extent; and can also improve the objective barrier repair and moisturizing ability of the composition for relieving sensitive skin itching and improving the barrier to a certain extent. It has been found that when the mass ratio of component A and component B is 1.6: 0.4, the overall comprehensive effect of the composition of the present invention is the best.

[0018] As a preferred embodiment of the first aspect, in the component A, the mass ratio of flaxseed extract to roxburghii fruit extract is flaxseed extract:roxburghii fruit extract=(0.1-1):(0.5-2).

[0019] Illustratively, in component A, the mass ratio of hemp seed extract and sea buckthorn fruit extract can be any point value between 1:(0.1-1):(0.5-2) or a range value between any two points, such as 0.1:0.5, 0.1:1.5, 0.1:2, 0.5:1.5, 0.5:2, 1:0.5, 1:1, 1:2.

[0020] As a preferred embodiment of the first aspect, in the component A, the mass ratio of flaxseed extract to roxburghii fruit extract is flaxseed extract: roxburghii fruit extract = (0.4-0.8): (0.8-1.5).

[0021] As a preferred embodiment of the first aspect, in the component A, the mass ratio of flaxseed extract to roxburghii fruit extract is flaxseed extract:roxburghii fruit extract=0.5:1.1.

[0022] The present invention has found that the mass ratio of flaxseed extract and roxburghii fruit extract in component A of the composition for alleviating sensitive skin itching and improving barrier will affect the inhibitory effect of the composition on inflammatory factors and the barrier repair efficacy to a certain extent, thereby affecting the anti-inflammatory and barrier repair capabilities of the composition. When the mass ratio of flaxseed extract and roxburghii fruit extract is further selected to be (0.1-1): (0.5-2), especially (0.4-0.8): (0.8-1.5), the anti-inflammatory and barrier repair capabilities of the composition can be improved. It has been found that when the mass ratio of flaxseed extract and roxburghii fruit extract is 0.5:1.1, the anti-inflammatory and barrier repair capabilities of the composition of the present invention are the best.

[0023] As a preferred embodiment of the first aspect, in the component B, the mass ratio of the Annona custardii extract to the Cyperus rotundus extract is: Annona custardii extract: Cyperus rotundus extract = (0.01-1): (0.01-0.5).

[0024] Illustratively, in component B, the mass ratio of the cherimoya extract to the cyperus rotundus extract can be any point value between (0.01-1):(0.01-0.5) or a range value between any two points, for example, 0.01:0.01, 0.01:0.1, 0.01:0.5, 0.05:0.01, 0.05:0.2, 0.05:0.5, 1:0.01, 1:0.1, 1:0.2, or 1:0.5.

[0025] As a preferred embodiment of the first aspect, in the component B, the mass ratio of the Annona custardii extract to the Cyperus rotundus extract is: Annona custardii extract: Cyperus rotundus extract = (0.1-0.5): (0.1-0.2).

[0026] As a preferred embodiment of the first aspect, in the component B, the mass ratio of the Annona chebula extract to the Cyperus rotundus extract is: Annona chebula extract: Cyperus rotundus extract = 0.28:0.12.

[0027] The present invention has found that the mass ratio of the custard apple extract and the cyperus rotundus extract in component B of the composition for relieving itching of sensitive skin and improving the barrier will affect the inhibitory effect of the composition on calcitonin gene-related peptide and the moisturizing effect to a certain extent, thereby affecting the composition's ability to improve itching and moisturize and replenish water. When the mass ratio of hemp seed extract and roxburghii fruit extract is further selected to be (0.01-1): (0.01-0.5), especially (0.1-0.5): (0.1-0.2), the composition's ability to improve itching and moisturize and replenish water can be improved. It has been found that when the mass ratio of the custard apple extract to the cyperus rotundus extract is 0.28: 0.12, the composition of the present invention has the best ability to improve itching and moisturize and replenish water.

[0028] As a preferred embodiment of the first aspect, the Cyperus rotundus extract is prepared by the following method:

[0029] The aerial part of the pennywort is dried and then crushed, the powder is added into water, extracted by subcritical water extraction method, the extracted product is collected and centrifuged, the supernatant is taken to obtain the pennywort extract; wherein the content of selenium polysaccharide in the pennywort extract is 20-50%.

[0030] As a preferred embodiment of the first aspect, the preparation method of the Cyperus rotundus extract satisfies at least one of the following conditions:

[0031] (a) the solid-to-liquid ratio of the indigo plant powder to water is 1:(10-40);

[0032] (b) A high-pressure reactor is used as a reaction vessel in the subcritical water extraction method; wherein the pressure of the high-pressure reactor is 5-9 MPa, the extraction temperature is 100-150° C., and the extraction time is 15-30 minutes.

[0033] The selenium polysaccharide contents in the Cyperus rotundus extract and the Cyperus rotundus extract obtained by different preparation methods of the present invention are different. When the solid-liquid ratio in the preparation method is 1:10; the extraction time is 15 minutes; the extraction temperature is 100°C and the pressure is 8MPa, the selenium polysaccharide content in the Cyperus rotundus extract and the Cyperus rotundus extract obtained is the highest, and the effect of the composition prepared thereby is better.

[0034] In a second aspect, the present invention provides use of the composition for alleviating itching of sensitive skin and improving barrier function as described in the first aspect in the preparation of cosmetics.

[0035] As a preferred embodiment of the second aspect, the cosmetics include one or more of lotion, emulsion, cream, mask, essence, and spray.

[0036] In a third aspect, the present invention provides a cosmetic comprising the composition for relieving itching of sensitive skin and improving the barrier.

[0037] As a preferred embodiment of the third aspect, the cosmetic comprises the following components in percentage by mass: 0.5-5% of the composition for alleviating itching of sensitive skin and improving barrier function, 4-40% of the cosmetic base, and the balance of water.

[0038] As a preferred embodiment of the third aspect, the cosmetic base includes at least one of a thickener, a moisturizer, an emulsifier, a preservative, and a pH adjuster.

[0039] As a preferred embodiment of the third aspect, the moisturizer includes at least one of allantoin, sodium polyacrylate, hydrogenated lecithin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, sodium hyaluronate, hydrolyzed sodium hyaluronate, 1,2-butylene glycol, glycerol, budding septin polysaccharide, D-panthenol, and ceramide.

[0040] As a preferred embodiment of the third aspect, the preservative includes at least one of 1,2-propylene glycol, 1,2-hexanediol, 1,2-pentanediol, and p-hydroxyacetophenone.

[0041] Compared with the prior art, the beneficial effects of the present invention are:

[0042] The present invention finds that flaxseed extract, roxburghii fruit extract, cherimoya extract and pennywort extract have a synergistic effect from numerous plant extracts, and they are formed into a composition through specific compatibility, which has the effects of improving facial itching of sensitive skin, reducing excessive neuronal activation and inhibiting inflammation, as well as repairing objective barriers and replenishing water and moisturizing. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 This is a comparison chart of facial desquamation of volunteers before and after use in Application Example 1 and Comparative Application Example 9 of the present invention (wherein more red indicates more desquamation). DETAILED DESCRIPTION

[0044] In order to better illustrate the purpose, technical scheme and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments. Its purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Unless otherwise specified, the experimental reagents and instruments designed for the implementation and comparative examples of the present invention are all commonly used ordinary reagents and instruments, which can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are conventional methods unless otherwise specified; and unless otherwise specified, the raw materials used in parallel experiments are from the same batch of raw materials. Further description of the raw materials used in the present invention:

[0045] Flaxseed extract was purchased from Ashland under the trade name Lipigenine TM ; Rosa roxburghii fruit extract was purchased from Biocosmethic Company under the trade name (Roxbirica roxburghii fruit extract (and) maltodextrin); AnnonaSense CLR extract was purchased from the cosmetic raw material company CLR Berlin under the trade name AnnonaSense CLR TM ; Sweet almond seed extract was purchased from Xi'an Qiancao Biotechnology Co., Ltd.; wood apple extract was purchased from Guangzhou Luojie Biotechnology Co., Ltd., with the trade name of tanaka extract C-Ⅰ; kava extract was purchased from Guangzhou Ganeng Biotechnology Co., Ltd.; watercress extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd.

[0046] Preparation method of Cyperus rotundus extract 1:

[0047] The subcritical water extraction (SWE) method was used for extraction, and the specific steps were as follows:

[0048] (1) Collect the aerial part of the radix serrata, wash it, dry it at 45°C until it reaches a constant weight, grind it, pass the powder through a 60-mesh sieve, collect it, and store it at room temperature after drying;

[0049] (2) extracting the powder in a high-pressure reactor at a pressure of 8 MPa at a solid-liquid ratio of 1:10 for 15 minutes at an extraction temperature of 100° C. to obtain a liquid extract;

[0050] (3) The liquid extract was centrifuged at 3000 rpm for 10 minutes, and the insoluble matter in the lower layer was removed to obtain the Cyperus rotundus extract. The content of selenium polysaccharide in the Cyperus rotundus extract was 50%.

[0051] Preparation method of Cyperus rotundus extract 2:

[0052] (1) Collect the aerial part of the radix spatholobi, wash it, dry it at 45°C until it reaches a constant weight, grind it, pass the powder through a 60-mesh sieve, collect it, and store it at room temperature after drying;

[0053] (2) extracting the powder in a high-pressure reactor at a pressure of 5 MPa at a solid-liquid ratio of 1:30 for 15 minutes at an extraction temperature of 150° C. to obtain a liquid extract;

[0054] (3) The liquid extract was centrifuged at 3000 rpm for 10 minutes, and the insoluble matter in the lower layer was removed to obtain the Cyperus rotundus extract. The content of selenium polysaccharide in the Cyperus rotundus extract was 40%.

[0055] Preparation method of Cyperus rotundus extract 3:

[0056] (1) Collect the aerial part of the radix spatholobi, wash it, dry it at 45°C until it reaches a constant weight, grind it, pass the powder through a 60-mesh sieve, collect it, and store it at room temperature after drying;

[0057] (2) extracting the powder in a high-pressure reactor at a pressure of 9 MPa at a solid-liquid ratio of 1:40 for 30 minutes and an extraction temperature of 120° C. to obtain a liquid extract;

[0058] (3) The liquid extract was centrifuged at 3000 rpm for 10 minutes, and the insoluble matter in the lower layer was removed to obtain the Cyperus rotundus extract. The content of selenium polysaccharide in the Cyperus rotundus extract was 20%.

[0059] The invention discloses a method for preparing a composition for relieving itching of sensitive skin and improving barrier, comprising the following steps: uniformly mixing the components according to corresponding proportions to obtain the composition.

[0060] Examples and Comparative Examples

[0061] The present application provides a composition for relieving itching of sensitive skin and improving barrier function. The components and weight proportions of the composition are shown in Table 1, wherein the comparative example uses Example 5 as a reference. For the missing components in Comparative Examples 3-6, the total amount thereof is the same as that in Example 5.

[0062] Table 1: Components and weight parts of Examples and Comparative Examples

[0063]

[0064]

[0065] Effect example:

[0066] Testing the effects of the composition of the present invention on reducing excessive neuronal activation and inhibiting inflammation: Experimental method: This effect example explores the effects of the composition prepared in the examples and comparative examples on inhibiting excessive neuronal activation and inhibiting inflammation.

[0067] Calcitonin gene-related peptide (CGRP) is a neurotransmitter. When irritants contact the skin, the substance will be transmitted in large quantities, and the inflammatory factor IL-33 will also be produced in large quantities. This is a substance that mediates itching and scratching, causing a series of problems such as skin itching, redness and swelling. During the cell culture process, the lower the CGRP content, the lower the neuronal activation, and the stronger the effect of the composition on improving itching. The lower the content of the inflammatory factor IL-33, the stronger the anti-inflammatory effect of the composition.

[0068] The cell line used in the present invention is human keratinocyte HaCaT (provided by Guangzhou Customs Testing Center), and the test conditions are: incubator temperature 37±1°C, saturated humidity, carbon dioxide 5±1%; cell culture and treatment are performed according to grouping, and then the calcitonin gene-related peptide (CGRP) content and inflammatory factor IL-33 content are tested, and the test method is as follows:

[0069] (1) Inoculate the cell suspension into a culture flask at a culture density of 1×10 6 / mL, using DMEM high-glucose culture medium (Gibco) containing 10% fetal bovine serum, and cultured for 24 hours;

[0070] (2) The control group and the sample group were treated with PBS buffer containing 100 μM histamine for 30 min, then the histamine-containing PBS solution was discarded and the cells were washed with PBS three times;

[0071] (3) The control group was added with DMEM high-glucose culture medium containing 10% fetal bovine serum, and the sample groups were added with DMEM high-glucose culture medium containing 0.1% of the pruritus improving composition prepared in the embodiment or comparative example (diluted with PBS) and 10% fetal bovine serum, and the cells were collected after culturing for 24 hours;

[0072] (4) Determination of CGRP and IL-33 content: The calcitonin gene-related peptide (CGRP) ELISA kit was used to detect the neuronal activation level of the cells, and the inflammatory factor IL-33 ELISA kit was used to detect the inflammatory factor content of the cells.

[0073] Histamine induces an increase in keratinocyte neuroreceptor transmission, which is marked by an increase in calcitonin gene-related peptide (CGRP). Therefore, after sample treatment, the lower the calcitonin gene-related peptide (CGRP) content, the lower the inflammatory factor IL-33 content, which means the lower the activity of the cell neurons, and the stronger the antipruritic and anti-inflammatory ability of the composition. The antipruritic ability of the composition is represented by the reduction of the calcitonin gene-related peptide (CGRP) content, and the anti-inflammatory ability of the composition is represented by the reduction of the inflammatory factor IL-33 content. The calculation formula is as follows:

[0074] CGRP inhibition rate (%) = (1-CGRP 样品组 / CGRP对照组 )×100%;

[0075] Inflammation inhibition rate (%) = (1-IL-33 样品组 / IL-33 对照组 )×100%.

[0076] The results are shown in Table 2:

[0077] Table 2: Test results of the antipruritic and anti-inflammatory abilities of the compositions

[0078] Group Itch nerve activation inhibition rate (%) Inflammation inhibition rate (%) Example 1 63.42 74.36 Example 2 67.21 72.95 Example 3 64.95 75.96 Example 4 65.38 76.88 Example 5 72.46 78.04 Example 6 73.22 75.28 Example 7 73.57 82.56 Example 8 73.14 73.29 Example 9 70.25 75.27 Example 10 78.36 75.68 Embodiment 11 73.28 74.89 Example 12 81.78 87.38 Embodiment 13 75.25 83.21 Embodiment 14 77.15 80.34 Comparative Example 1 47.05 61.47 Comparative Example 2 51.42 62.64 Comparative Example 3 25.47 32.94 Comparative Example 4 23.04 37.25 Comparative Example 5 13.94 27.94 Comparative Example 6 25.47 32.94 Comparative Example 7 37.90 54.21 Comparative Example 8 40.83 57.34 Comparative Example 9 31.94 49.85 Comparative Example 10 35.38 38.91

[0079] It can be seen from Table 2 that the composition for alleviating sensitive skin itching and improving barrier function provided by the present invention can inhibit itch nerve activation and inflammatory response, which indicates that the composition of the present invention has the efficacy of alleviating sensitive skin itching and anti-inflammatory.

[0080] Compared with the comparative example group, the itch nerve activation inhibition rate and the inflammation inhibition rate of the embodiment group are higher than those of the comparative example group. It can be seen that the composition of the present invention can improve the itch nerve activation inhibition rate and the inflammation inhibition rate of the composition within a certain weight ratio range through specific components, and the itch nerve activation inhibition rate is above 60%, and the inflammation inhibition rate is above 70%.

[0081] In Examples 1-5, it can be seen that the mass ratio of the components in the composition for relieving itching of sensitive skin and improving the barrier will affect the ability of the composition to inhibit itch nerve activation and inflammatory response. When the mass parts of the components are limited to the mass ratio of component A to component B (0.6-3): (0.02-1.5), the obtained composition has a good effect of improving itching and inhibiting inflammation. When the mass ratio of component A to component B is further selected to be in the range of (1.2-2.3): (0.2-0.7), the obtained composition has a better effect of inhibiting itch nerve activation and inflammatory response. When the mass ratio of component A to component B is 1.6: 0.4 (Example 5), the effect is best.

[0082] The present invention studies the influence of the mass ratio of linseed extract and roxburghii fruit extract in component A on the ability of the composition to inhibit inflammation through Examples 6-8. It can be seen from Examples 6-8 that the mass ratio of linseed extract and roxburghii fruit extract affects the effect of the composition on inhibiting inflammation, thereby affecting the anti-inflammatory efficacy of the composition. When the mass ratio of linseed extract and roxburghii fruit extract is limited to the range of (0.1-1): (0.5-2), the anti-inflammatory efficacy of the composition can be improved. When the mass ratio of linseed extract and roxburghii fruit extract is further limited to the range of (0.4-0.8): (0.8-1.5), the effect of the obtained combination is better. When the mass ratio of linseed extract and roxburghii fruit extract is 0.5: 1.1 (Example 7), the effect is best.

[0083] The present invention studies the influence of the mass ratio of the custard apple extract and the cyperus rotundus extract in component B on the itch nerve activation inhibition ability of the composition through Examples 9-11. It can be seen from Examples 9-11 that the mass ratio of the custard apple extract and the cyperus rotundus extract affects the effect of the composition on the inhibition of itch nerve activation, thereby affecting the anti-itching effect of the composition. When the mass ratio of the custard apple extract and the cyperus rotundus extract is limited to the range of (0.01-1): (0.01-0.5), the anti-itching effect of the composition can be improved. When the mass ratio of the custard apple extract and the cyperus rotundus extract is further limited to the range of (0.1-0.5): (0.1-0.2), the effect of the obtained combination is better. When the mass ratio of the custard apple extract and the cyperus rotundus extract is 0.28: 0.12 (Example 10), the effect is best.

[0084] The results obtained in Examples 6-11 were combined to obtain the composition with the best effect in Example 12.

[0085] The present invention studies the effects of the Cyperus rotundus extracts extracted by different methods on the efficacy of the composition. It can be seen from Examples 12-14 that the Cyperus rotundus extracts prepared by the methods of Examples 13-14 are not as effective as that of Example 12.

[0086] The itch nerve activation inhibition rate of comparative example 1-2 is 40-50%, and the inflammation inhibition rate is about 60%. This is because the mass ratios of the components in the composition of comparative example 1-2 are not within the scope of the present invention, which affects the synergistic effect between the components and reduces the efficacy of the composition.

[0087] The itch nerve activation inhibition rate of comparative example 3-6 is less than 30%, and the inflammation inhibition rate is about 30%. This is because the comparative example 3-6 composition lacks one of the components of the present invention, which affects the synergistic effect between the components and reduces the efficacy of the composition.

[0088] The itch nerve activation inhibition rate of comparative examples 7-10 is 30-40%, and the inflammation inhibition rate is 30-50%. This is because the comparative examples 7-10 compositions replace one of the components in the combination group of the present invention with other plant extracts, which do not produce a synergistic effect with the specific components selected by the present invention, and also affect the synergistic effect between other components of the present invention, thereby reducing the efficacy of the composition.

[0089] Application Examples

[0090] The application examples of the present invention and the comparative application examples provide a spray, and the components (mass percentage) of the spray are shown in Table 3; wherein the compositions for relieving itching of sensitive skin and improving the barrier used in application examples 1-14 are respectively the compositions for relieving itching of sensitive skin and improving the barrier prepared in Examples 1-14, and the compositions for relieving itching of sensitive skin and improving the barrier used in application examples 15 and 16 are the compositions for relieving itching of sensitive skin and improving the barrier prepared in Example 1; the compositions for relieving itching of sensitive skin and improving the barrier used in comparative application examples 1-10 are respectively the compositions for relieving itching of sensitive skin and improving the barrier prepared in comparative examples 1-10; in addition, a blank application example is set, and the only difference between the blank application example and application example 1 is that the composition for relieving itching of sensitive skin and improving the barrier is not added;

[0091] Table 3:

[0092]

[0093] Application Example 1 provides the above-mentioned spray preparation method: after all the ingredients are mixed, they are put into an aluminum aerosol can to form a spray. The spray preparation methods provided in Application Examples 2-16, Comparative Application Examples 1-10 and Blank Application Examples are consistent with those in Application Example 1.

[0094] Test application example: The spray has antipruritic, repairing, hydrating and moisturizing effects on sensitive skin. The specific method is as follows:

[0095] 1. Objective evaluation of barrier repair and hydration and moisturizing effects:

[0096] Patients with skin barrier damage (TEWL ≥ 20 g / hm 2 125 volunteers with sensitive skin (lactic acid positive) were recruited. At the same time, a self-assessment questionnaire was used to determine whether the volunteers often had itching problems (at least 5 times a month). They were aged 20-50 years old. On the day of the volunteer visit, no products were applied to the test area (face). After washing the face, the volunteers sat in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 20 minutes. Then they were randomly divided into 25 groups, with 5 people in each group. TM Hex (Courage+Khazaka) and skin moisture probe CM 825 measures the initial TEWL value and initial moisture content of the left and right faces of each volunteer, and VC20 is used to detect the skin smoothness index (SEsm value), and the average value is taken. Each group of volunteers uses the spray in the morning and evening, and also uses the spray when the face feels itchy or uncomfortable. There is no limit to the number of times a day, and at least 2 times of use are guaranteed. When using, press the spray around the face three times to ensure that the face is fully moisturized. The first group of subjects used the blank application example (blank spray without the composition), and the second group of subjects used application example 1, and then on the 14th day and the 28th day, the TEWL value and moisture content of the facial skin after use were measured again, and the average value was taken, and then the corresponding average value was used to calculate the respective improvement rate (%) according to the following formula:

[0097] TEWL value improvement rate (%) = (initial TEWL value - TEWL value after use) / initial TEWL value × 100%;

[0098] Moisture content improvement rate (%) = (moisture content after use - initial moisture content) / initial moisture content × 100%;

[0099] SEsm value improvement rate (%) = (initial SEsm value - SEsm value after use) / initial SEsm value × 100%;

[0100] Among them, the greater the improvement rate of TEWL value, the stronger the skin barrier damage repair ability of the spray; the greater the improvement rate of skin moisture content, the stronger the moisturizing and hydrating ability of the spray; the greater the improvement rate of SEsm value, the lower the skin roughness and the smoother the skin; the results are shown in Table 4:

[0101] Table 4: Objective barrier repair and hydration evaluation results of each spray product

[0102]

[0103]

[0104] Note: The blank application example does not contain the composition of the present invention, and the rest is the same as the application example.

[0105] As can be seen from Table 4, compared with the comparative example group, the TEWL value improvement rate of the application example group after 28 days is more than 15%, the water content improvement rate is more than 20%, and the smoothness improvement rate is more than 30%. It can be seen that the composition of the present invention can improve the TEWL value improvement rate, water content improvement rate and smoothness improvement rate of the composition within a certain weight ratio range through specific components, thereby improving the composition's ability to repair skin barrier damage, moisturize and smooth the skin, and improve roughness.

[0106] It can be seen from Application Examples 1-5 that the mass ratio of the components in the spray product will affect the TEWL value, water content, and smoothness of the composition. When the mass ratio of the components is limited to the range of (0.6-3) to (0.02-1.5) of the mass ratio of component A to component B, the obtained product has a good effect of improving the TEWL value, water content, and smoothness, thereby enhancing the product's skin barrier damage repair ability and roughness improvement, moisturizing and hydrating ability. When the mass ratio of component A to component B is further selected to be within the range of (1.2-2.3) to (0.2-0.7), the obtained composition has better skin barrier damage repair ability, roughness improvement ability, and moisturizing and hydrating effects. When the mass ratio of component A to component B is 1.6:0.4 (Application Example 5), the effect is best.

[0107] The present invention studies the influence of the mass ratio of flaxseed extract and roxburghii fruit extract in component A on the ability of the product to repair skin barrier damage through application examples 6-8. It can be seen from application examples 6-8 that the mass ratio of flaxseed extract and roxburghii fruit extract affects the effect of the composition on improving the TEWL value, thereby affecting the efficacy of the composition on repairing skin barrier damage. When the mass ratio of flaxseed extract and roxburghii fruit extract is limited to the range of (0.1-1): (0.5-2), the efficacy of the composition on repairing skin barrier damage can be improved. When the mass ratio of flaxseed extract and roxburghii fruit extract is further limited to the range of (0.4-0.8): (0.8-1.5), the effect of the obtained combination is better. When the mass ratio of flaxseed extract and roxburghii fruit extract is 0.5:1.1 (application example 7), the effect is best.

[0108] The present invention studies the influence of the mass ratio of the custard apple extract and the cyperus rotundus extract in component B on the moisturizing and improving roughness of the product through application examples 9-11. It can be seen from application examples 9-11 that the mass ratio of the custard apple extract and the cyperus rotundus extract affects the effect of the composition on improving the water content of the skin, thereby affecting the moisturizing and improving roughness of the composition. When the mass ratio of the custard apple extract and the cyperus rotundus extract is limited to the range of (0.01-1): (0.01-0.5), the moisturizing and improving roughness of the composition can be improved. When the mass ratio of the custard apple extract and the cyperus rotundus extract is further limited to the range of (0.1-0.5): (0.1-0.2), the effect of the obtained composition is better. When the mass ratio of the custard apple extract and the cyperus rotundus extract is 0.28: 0.12 (application example 10), the effect is best.

[0109] The present invention studies the effects of the Cyperus rotundus extracts extracted by different methods on the efficacy of the composition. It can be seen from Application Examples 12-14 that the effects of the Cyperus rotundus extracts prepared by the methods of Application Examples 13-14 are not as good as those of Application Example 12.

[0110] The TEWL value improvement rate of comparative application examples 1-2 is 10-11%, the water content improvement rate is 17-18%, and the smoothness improvement rate is less than 30%. This is because the mass ratios of the components in the compositions of comparative examples 1-2 are not within the scope of the present invention, which affects the synergistic effect between the components and reduces the efficacy of the composition.

[0111] The TEWL value improvement rate of comparative application examples 3-6 is 6-7%, the water content improvement rate is 14-15%, and the smoothness improvement rate is less than 20%. This is because the comparative examples 3-6 compositions lack one of the components of the present invention, which affects the synergistic effect between the components and reduces the efficacy of the composition.

[0112] The TEWL value improvement rate of comparative application examples 7-10 is about 6%, the water content improvement rate is 12-14%, and the smoothness improvement rate is lower than 16%. This is because the comparative application examples 7-10 compositions replace one of the components in the combination group of the present invention with other plant extracts, which do not produce a synergistic effect with the specific components selected by the present invention, and also affect the synergistic effect between other components of the present invention, thereby reducing the efficacy of the composition.

[0113] 2 Subjective itch improvement assessment:

[0114] Because itching is a subjective feeling that cannot be quantified at present, the antipruritic effect of the spray on the face of people with sensitive skin is calculated using the nimodipine method, and the initial skin symptoms of the subjects are observed, including skin redness, rash, dryness, tingling, burning pain, itching and other discomforts, and the situation is recorded. Among them, slight scaling of the skin, slight dryness, and slight itching discomfort are scored as 1 point, the above feelings are obviously scored as 2 points, and severe scores are scored as 3 points. Improvement index = (pre-treatment score-post-treatment score) / pre-treatment score × 100%, divided into 4 levels according to the efficacy index: complete improvement, significant improvement, improvement, and ineffectiveness. Complete improvement (improvement index>90%), significant improvement (improvement index 60%-89%), improvement (improvement index 20%-59%), ineffective (improvement index<20%).

[0115] Total effective rate % = (number of completely improved cases + number of significantly improved cases + number of improved cases) / total number of treated cases × 100%.

[0116] Table 5: Subjective itch improvement assessment results

[0117]

[0118]

[0119] Note: The blank application example does not contain the composition of the present invention, and the rest is the same as the application example.

[0120] It can be seen from Table 5 that, compared with the control group, the total effective rate of pruritus improvement in the application example group is higher than 75%. It can be seen that the composition of the present invention can improve the pruritus improvement ability of the product through specific components within a certain weight ratio range.

[0121] It can be seen from Application Examples 1-5 that the mass ratio of the components in the spray product affects the ability of the composition to improve itching. When the mass ratio of the components is limited to the range of (0.6-3) to (0.02-1.5) of the mass ratio of component A to component B, the ability of the product to improve itching is improved. When the mass ratio of component A to component B is further selected to be within the range of (1.2-2.3) to (0.2-0.7), the effect of improving itching of the obtained composition is better. When the mass ratio of component A to component B is 1.6:0.4, the effect is the best.

[0122] The present invention studies the mass ratio of flaxseed extract and roxburghii fruit extract in component A through application examples 6-8 to determine the ability of the product to improve itching. It can be seen from application examples 6-8 that the mass ratio of flaxseed extract and roxburghii fruit extract affects the effect of the composition on improving itching, because the mass ratio of flaxseed extract and roxburghii fruit extract affects the anti-inflammatory effect of the combination, thereby affecting the overall effect of the composition on improving itching. When the mass ratio of flaxseed extract and roxburghii fruit extract is limited to the range of (0.1-1): (0.5-2), the effect of improving itching of the composition can be improved. When the mass ratio of flaxseed extract and roxburghii fruit extract is further limited to the range of (0.4-0.8): (0.8-1.5), the effect of the obtained composition is better. When the mass ratio of flaxseed extract and roxburghii fruit extract is 0.5: 1.1, the effect is best.

[0123] The present invention studies the influence of the mass ratio of the custard apple extract and the cyperus rotundus extract in component B on the ability of the product to improve itching through application examples 9-11. It can be seen from application examples 9-11 that the mass ratio of the custard apple extract and the cyperus rotundus extract affects the effect of the composition on improving itching. When the mass ratio of the custard apple extract and the cyperus rotundus extract is limited to the range of (0.01-1): (0.01-0.5), the pruritus improving effect of the composition can be improved. When the mass ratio of the custard apple extract and the cyperus rotundus extract is further limited to the range of (0.1-0.5): (0.1-0.2), the effect of the obtained composition is better. When the mass ratio of the custard apple extract and the cyperus rotundus extract is 0.28: 0.12, the effect is best.

[0124] The present invention studies the effects of the Cyperus rotundus extracts extracted by different methods on the efficacy of the composition. It can be seen from Application Examples 12-14 that the effects of the Cyperus rotundus extracts prepared by the methods of Application Examples 13-14 are not as good as those of Application Example 12.

[0125] The total effective rate of itching improvement in Comparative Application Examples 1-2 is 60%. This is because the mass ratios of the components in the compositions of Comparative Application Examples 1-2 are not within the scope of the present invention, which affects the synergistic effect between the components and reduces the efficacy of the composition.

[0126] The total effective rate of itching improvement in comparative application examples 3-6 is 20-60%. This is because the lack of one of the components of the present invention in the composition of comparative application examples 3-6 affects the synergistic effect between the components and reduces the efficacy of the composition.

[0127] The total effective rate of itching improvement in Comparative Application Examples 7-10 is 20%. This is because the composition of Comparative Application Examples 7-10 replaces one of the components in the combination group of the present invention with other plant extracts, which does not produce a synergistic effect with the specific components selected by the present invention, and also affects the synergistic effect between other components of the present invention, thereby reducing the efficacy of the composition.

[0128] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for relieving itching of sensitive skin and improving the barrier, characterized in that: The composition comprises component A and component B; The component A comprises flaxseed extract and roxburghii fruit extract; The component B comprises Annona chebula extract and Cyperus rotundus extract.

2. The composition according to claim 1, characterized in that The mass ratio of component A to component B in the composition is component A:component B=(0.6-3):(0.02-1.5).

3. The composition according to claim 2, characterized in that The mass ratio of component A to component B in the composition is component A:component B=(1.2-2.3):(0.2-0.7).

4. The composition according to claim 1, characterized in that In the component A, the mass ratio of flaxseed extract to roxburghii fruit extract is flaxseed extract:roxburghii fruit extract=(0.1-1):(0.5-2).

5. The composition according to claim 4, characterized in that In the component A, the mass ratio of flaxseed extract to roxburghii fruit extract is flaxseed extract:roxburghii fruit extract=(0.4-0.8):(0.8-1.5).

6. The composition according to claim 1, characterized in that In the component B, the mass ratio of the Annona custardii extract to the Cyperus rotundus extract is: Annona custardii extract: Cyperus rotundus extract = (0.01-1): (0.01-0.5).

7. The composition according to claim 6, characterized in that In the component B, the mass ratio of the Annona custardii extract to the Cyperus rotundus extract is: Annona custardii extract: Cyperus rotundus extract = (0.1-0.5): (0.1-0.2).

8. The composition according to any one of claims 1 to 7, characterized in that The extract of Cyperus rotundus is prepared by the following method: The aerial part of the pennywort is dried and then crushed, the powder is added into water, extracted by subcritical water extraction method, the extracted product is collected and centrifuged, the supernatant is taken to obtain the pennywort extract; wherein the content of selenium polysaccharide in the pennywort extract is 20-50%.

9. The composition according to claim 8, characterized in that Satisfy at least one of the following: (a) the solid-to-liquid ratio of the indigo plant powder to water is 1:(10-40); (b) A high-pressure reactor is used as a reaction vessel in the subcritical water extraction method; wherein the pressure of the high-pressure reactor is 5-9 MPa, the extraction temperature is 100-150° C., and the extraction time is 15-30 minutes.

10. Use of the composition according to any one of claims 1 to 9 in the preparation of cosmetics.

11. The use according to claim 10, characterized in that The cosmetics include one or more of lotion, emulsion, cream, mask, essence, and spray.

12. A cosmetic, characterized in that: The cosmetic comprises the composition according to any one of claims 1 to 9.

13. The cosmetic according to claim 12, characterized in that The cosmetic comprises the following components in percentage by mass: 0.5-5% of the composition according to any one of claims 1 to 9, 4-40% of a cosmetic base, and the balance being water.

14. The cosmetic according to claim 13, characterized in that The cosmetic matrix includes at least one of a thickener, a moisturizer, an emulsifier, a preservative, and a pH adjuster.

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