An ultra-low molecular weight anti-shedding liquid

Abstract

The invention relates to an ultra-low molecular weight anti-hair loss liquid. According to the invention, butanediol, L-1,4-dithiothreitol, castor oil triglycidyl ether and baking soda are stirred for reaction; isoeugenol acetate is then added and the mixture is kept warm for reaction; water and pyridoxine hydrochloride are then added and the reaction is continued; ginger root extract, Ligustrum lucidum fruit extract, Chuanxiong extract, Forsythia suspensa extract, Sanguisorba officinalis root extract, Polygonum multiflorum extract, Platycladus orientalis leaf extract, Sophora flavescens root extract and Truncatum pratense extract are then added and the mixture is stirred for reaction, then cooled to room temperature, citric acid is added to adjust pH value, and the ultra-low molecular weight anti-hair loss liquid is obtained. The ultra-low molecular weight anti-hair loss liquid prepared by the invention can effectively improve scalp itching, oiliness and dandruff, and has a certain anti-hair loss and hair growth effect.

Description

Technical Field

[0001] The invention relates to the technical field of anti-shedding liquid, in particular to an ultra-low molecular anti-shedding liquid. Background Art

[0002] As a part of the body structure, hair plays an important role in our daily life. Healthy and beautiful hair makes people more confident in interpersonal communication. Similarly, various hair diseases, such as hair loss, thin hair, dandruff, etc., can make people feel inferior, anxious and other negative psychological problems. In severe cases, it can even affect social activities. Therefore, we have to pay attention to hair care in our daily life.

[0003] Chinese patent CN106852784A: It relates to the field of hair care, specifically, a hair loss prevention and hair growth shampoo. It is composed of the following materials in parts by weight: 25-30 parts of almond oil, 15-20 parts of coconut oil monoethanolamide, 35-40 parts of beer, 15-20 parts of white vinegar, 35-45 parts of saponin solution, 10-15 parts of guar gum, 15-25 parts of cocamidopropyl lactone, 15-20 parts of alkyl polyglucose, 35-45 parts of traditional Chinese medicine extract, 25-35 parts of plant extract, 15-20 parts of essence, and 45-60 parts of purified water.

[0004] Chinese patent CN108143669B: discloses an anti-hair loss and hair growth shampoo and its preparation method. The anti-hair loss and hair growth shampoo, by weight, comprises: 80-85 parts of shampoo base and 15-20 parts of anti-hair loss and hair growth liquid, wherein the anti-hair loss and hair growth liquid, by weight, comprises: 70-80 parts of ginger-peony bark extract liposome suspension and 20-30 parts of astragalus extract liposome suspension. The anti-hair loss and hair growth liquid, by weight, may also comprise: 0.01-0.1 parts of ethyl α-cyano-4-p-hydroxycinnamate.

[0005] Chinese patent CN110731922B: Provides an enhanced anti-hair loss and hair growth composition, comprising (A) concentrated birch sap and (B) a combination of any one or more of ginger extract, Polygonum multiflorum root extract, ginseng extract, green tea extract, Platycladus orientalis extract, Angelica sinensis extract, Astragalus, Eclipta prostrata, birch bud extract, birch leaf extract, adenosine, niacinamide, and tripeptide-1 copper, wherein the concentration multiple of the concentrated birch sap is about 1.2-8 times, preferably about 1.5-6 times, and more preferably about 1.5-5 times.

[0006] After consumers use the shampoo prepared by the above patents and prior art, they still have obvious dandruff, itchy scalp, and greasy scalp, and the anti-hair loss and hair growth effects need to be further improved. Summary of the invention

[0007] In order to solve the above problems, the present invention provides an ultra-low molecular weight anti-shedding liquid, and the operation steps are as follows:

[0008] S1: by weight, 40-50 parts of butanediol, 0.5-2.7 parts of L-1,4-dithiothreitol, 0.03-0.3 parts of castor oil triglycidyl ether, and 0.3-3 parts of baking soda are stirred for reaction;

[0009] S2: Add 0.5-2 parts of isoeugenol acetate and keep warm for reaction;

[0010] S3: Add 10-20 parts of water and 0.1-0.5 parts of pyridoxine hydrochloride, and stir to react for 30-60 minutes;

[0011] S4: Add 1-5 parts of ginger root extract, 0.2-1.8 parts of Ligustrum lucidum fruit extract, 2-6 parts of Chuanxiong extract, 0.1-1 parts of Forsythia suspensa extract, 0.2-1.2 parts of Sanguisorba officinalis root extract, 0.5-1.5 parts of Polygonum multiflorum extract, 1-5 parts of Platycladus orientalis leaf extract, 1-5 parts of Sophora flavescens root extract, and 0.5-2.5 parts of Truncatum pratense extract, and stir to react;

[0012] S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

[0013] The reaction temperature of S1 is 50-60°C and the reaction time is 120-180 minutes.

[0014] The reaction time of S2 is 50-100 min.

[0015] The reaction temperature of S3 is 40-50°C and the reaction time is 100-150 minutes.

[0016] The stirring rate is 300-500r / min.

[0017] The S5 adjusts the pH value to 5.5-6.5.

[0018] Reaction mechanism

[0019] 1. Mercapto-epoxy ring-opening reaction:

[0020] L-1,4-dithiothreitol (DTE) is a compound containing two thiol groups (SH); castor oil triglycidyl ether (Epox idi zedcastoro il) contains an epox ide group; at 50-60°C, the thiol group of DTE nucleophilically attacks the epoxies of castor oil triglycidyl ether, causing the epoxies to open, forming new hydroxyl groups (OH) and thioether bonds (CS), thereby generating a surface-active substance.

[0021] 2. Double bond addition reaction of thiol and isoeugenol acetate:

[0022] Eugenol acetate is an ester compound containing an aromatic ring and a double bond; the thiol-containing product formed in S1 continues to undergo addition reaction with the double bond in isoeugenol acetate to form a new chemical bond; this reaction can increase the molecular weight and complexity of the product, thereby improving its surface activity and cleaning ability.

[0023] Technical Effects

[0024] The ultra-low molecular weight anti-shedding liquid of the present invention has the following significant effects compared with the prior art:

[0025] 1. Improve cleaning ability:

[0026] The synergistic effect of butanediol and L-1,4-dithiothreitol enhances the detergency of shampoo. As a moisturizer, butanediol softens dirt on the hair and scalp, making it easier to wash off. L-1,4-dithiothreitol has reducing properties and can effectively remove oils and oxidative substances, thereby improving the overall cleaning effect. Castor oil triglycidyl ether undergoes a ring-opening reaction with thiol groups, and the resulting surfactant helps to emulsify and disperse dirt, further enhancing the cleaning performance of the shampoo.

[0027] 2. Enhance hair care effect:

[0028] Isoeugenol acetate undergoes an addition reaction with thiol groups to form stable compounds. These compounds not only have good surface activity, but can also form a protective film on the surface of hair to reduce water loss and maintain the moisture and softness of the hair. Castor oil itself is rich in nutrients such as fatty acids and vitamin E. After epoxidation treatment, its moisturizing and lubricity are further enhanced, which helps to repair damaged hair and make hair smoother and more shiny.

[0029] 3. Improve user experience:

[0030] Isoeugenol acetate has a natural aromatic smell, which gives the shampoo a pleasant fragrance and enhances the user experience; at the same time, its antibacterial and anti-inflammatory properties can help relieve scalp inflammation and itching, and is suitable for people with sensitive scalp or scalp problems; as a reducing agent, it can adjust the pH value of the shampoo, making it milder, reducing irritation to the scalp and improving comfort of use. DETAILED DESCRIPTION

[0031] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following is a detailed description in combination with embodiments and comparative examples:

[0032] 30 volunteers were selected from each group to participate in the experiment. The volunteers were between 18 and 60 years old, regardless of gender. They suffered from seborrheic alopecia and physiological alopecia, and had no other diseases that might affect the results of the observation. They had not used similar anti-hair loss and hair growth products in the three months before the start of the experiment and could voluntarily cooperate in completing the observation as required.

[0033] 210 volunteers were divided into seven groups for testing, with 30 people in each group. The test period was 4 weeks, with shampooing every 2 days, 5g each time; the volunteers were observed for dandruff, scalp itching, oiliness, hair loss, and hair growth effect after 8 weeks of continuous use.

[0034] The test results are shown in Table 1.

[0035] Example 1

[0036] An ultra-low molecular weight anti-shedding liquid, the operation steps of which are:

[0037] S1: 40g of butanediol, 0.5g of L-1,4-dithiothreitol, 0.03g of castor oil triglycidyl ether, and 0.3g of baking soda were stirred for reaction;

[0038] S2: Add 0.5 g of isoeugenol acetate and keep warm for reaction;

[0039] S3: Add 10 g of water and 0.1 g of pyridoxine hydrochloride, and stir to react for 30 minutes;

[0040] S4: Add 1g ginger root extract, 0.2g Ligustrum lucidum fruit extract, 2g Chuanxiong extract, 0.1g Forsythia suspensa extract, 0.2g Sanguisorba officinalis root extract, 0.5g Polygonum multiflorum extract, 1g Platycladus orientalis leaf extract, 1g Sophora flavescens root extract, and 0.5g Thunbergia praeparata extract, and stir to react;

[0041] S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

[0042] The reaction temperature of S1 is 50°C and the reaction time is 120 minutes.

[0043] The reaction time of S2 is 50 min.

[0044] The reaction temperature of S3 is 40°C and the reaction time is 100 min.

[0045] The stirring rate is 300 r / min.

[0046] The S5 adjusts the pH value to 5.5.

[0047] Example 2

[0048] An ultra-low molecular weight anti-shedding liquid, the operation steps of which are:

[0049] S1: 43g of butanediol, 1g of L-1,4-dithiothreitol, 0.1g of castor oil triglycidyl ether, and 1g of baking soda were stirred for reaction;

[0050] S2: Add 1 g of isoeugenol acetate and keep warm for reaction;

[0051] S3: Add 13 g of water and 0.2 g of pyridoxine hydrochloride, and stir to react for 40 minutes;

[0052] S4: Add 2g ginger root extract, 0.8g Ligustrum lucidum fruit extract, 3g Chuanxiong extract, 0.5g Forsythia suspensa extract, 0.7g Sanguisorba officinalis root extract, 0.8g Polygonum multiflorum extract, 2g Platycladus orientalis leaf extract, 2g Sophora flavescens root extract, and 1g Truncatum pratense extract, and stir to react;

[0053] S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

[0054] The reaction temperature of S1 is 55°C and the reaction time is 140 minutes.

[0055] The reaction time of S2 is 60 min.

[0056] The reaction temperature of S3 is 45°C and the reaction time is 110 minutes.

[0057] The stirring rate is 350 r / min.

[0058] The S5 adjusts the pH value to 6.

[0059] Example 3

[0060] An ultra-low molecular weight anti-shedding liquid, the operation steps of which are:

[0061] S1: 48g of butanediol, 2g of L-1,4-dithiothreitol, 0.2g of castor oil triglycidyl ether, and 2g of baking soda were stirred for reaction;

[0062] S2: Add 1.5 g of isoeugenol acetate and keep warm for reaction;

[0063] S3: Add 18 g of water and 0.4 g of pyridoxine hydrochloride, and stir to react for 50 minutes;

[0064] S4: Add 4g ginger root extract, 1.4g Ligustrum lucidum fruit extract, 5g Chuanxiong extract, 0.8g Forsythia suspensa extract, 1g Sanguisorba officinalis root extract, 1.3g Polygonum multiflorum extract, 4g Platycladus orientalis leaf extract, 4g Sophora flavescens root extract, and 2g Truncatum pratense extract, and stir to react;

[0065] S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

[0066] The reaction temperature of S1 is 55°C and the reaction time is 160 min.

[0067] The reaction time of S2 is 90 min.

[0068] The reaction temperature of S3 is 45°C and the reaction time is 140 minutes.

[0069] The stirring rate is 450 r / min.

[0070] The S5 adjusts the pH value to 6.

[0071] Example 4

[0072] An ultra-low molecular weight anti-shedding liquid, the operation steps of which are:

[0073] S1: 50g of butanediol, 2.7g of L-1,4-dithiothreitol, 0.3g of castor oil triglycidyl ether, and 3g of baking soda were stirred for reaction;

[0074] S2: Add 2 g of isoeugenol acetate and keep warm for reaction;

[0075] S3: Add 20 g of water and 0.5 g of pyridoxine hydrochloride, and stir to react for 60 minutes;

[0076] S4: Add 5g ginger root extract, 1.8g Ligustrum lucidum fruit extract, 6g Chuanxiong extract, 1g Forsythia suspensa extract, 1.2g Sanguisorba officinalis root extract, 1.5g Polygonum multiflorum extract, 5g Platycladus orientalis leaf extract, 5g Sophora flavescens root extract, and 2.5g Truncatum chinense extract, and stir to react;

[0077] S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

[0078] The reaction temperature of S1 is 60°C and the reaction time is 180 min.

[0079] The reaction time of S2 is 100 min.

[0080] The reaction temperature of S3 is 50°C and the reaction time is 150 minutes.

[0081] The stirring rate is 500 r / min.

[0082] The S5 adjusts the pH value to 6.5.

[0083] Comparative Example 1

[0084] L-1,4-dithiothreitol, castor oil triglycidyl ether and isoeugenol acetate were not added, and the rest was the same as in Example 1.

[0085] Comparative Example 2

[0086] The other steps were the same as in Example 1 except that castor oil triglycidyl ether was not added.

[0087] Comparative Example 3

[0088] No isoeugenol acetate was added, and the rest was the same as in Example 1.

[0089] Table 1

[0090]

[0091]

[0092] Through the data analysis of the above embodiments and comparative examples, the ultra-low molecular weight anti-hair loss liquid prepared by the present invention can effectively improve the itchy, oily and dandruff conditions of the scalp, and has a certain anti-hair loss and hair growth effect.

[0093] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. An ultra-low molecular weight anti-shedding liquid, the operation steps of which are: S1: by weight, 40-50 parts of butanediol, 0.5-2.7 parts of L-1,4-dithiothreitol, 0.03-0.3 parts of castor oil triglycidyl ether, and 0.3-3 parts of baking soda are stirred for reaction; S2: Add 0.5-2 parts of isoeugenol acetate and keep warm for reaction; S3: Add 10-20 parts of water and 0.1-0.5 parts of pyridoxine hydrochloride, and stir to react for 30-60 minutes; S4: Add 1-5 parts of ginger root extract, 0.2-1.8 parts of Ligustrum lucidum fruit extract, 2-6 parts of Chuanxiong extract, 0.1-1 parts of Forsythia suspensa extract, 0.2-1.2 parts of Sanguisorba officinalis root extract, 0.5-1.5 parts of Polygonum multiflorum extract, 1-5 parts of Platycladus orientalis leaf extract, 1-5 parts of Sophora flavescens root extract, and 0.5-2.5 parts of Truncatum pratense extract, and stir to react; S5: After cooling to room temperature, citric acid is added to adjust the pH value to obtain an ultra-low molecular weight anti-shedding liquid.

2. The ultra-low molecular weight anti-shedding liquid according to claim 1, characterized in that: The reaction temperature of S1 is 50-60°C and the reaction time is 120-180 minutes.

3. The ultra-low molecular weight anti-shedding liquid according to claim 1, characterized in that: The reaction time of S2 is 50-100 min.

4. The ultra-low molecular weight anti-shedding liquid according to claim 1, characterized in that: The reaction temperature of S3 is 40-50°C and the reaction time is 100-150 minutes.

5. The ultra-low molecular weight anti-shedding liquid according to claim 1, characterized in that: The stirring rate is 300-500r / min.

6. The ultra-low molecular weight anti-shedding liquid according to claim 1, characterized in that: The S5 adjusts the pH value to 5.5-6.5.

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