A kind of Huoluo enema soup for clearing away heat, detoxifying, removing blood stasis, dispersing knots and relieving pain

Abstract

The invention relates to a pharmaceutical preparation, in particular to a collateral-activating enema soup capable of clearing away heat and toxic substances, removing blood stasis, dispersing stagnation and relieving pain, comprising: oldenlandia diffusa and Scutellaria barbata as main drugs, Gleditsia sinensis, Curcuma zedoaria, Paeonia suffruticosa, cinnamon twig, rhubarb, Trillium gracile, Caulis serrata and Patrinia scabra as assistant drugs, and Corydalis yanhusuo and Luffa fructus as adjuvant drugs. The prescription is suitable for patients with pelvic mass, pelvic inflammatory disease, pelvic adhesion infertility, endometriosis, adenomyosis and the like accompanied with or without abdominal pain, and the syndrome belongs to damp-heat stasis syndrome, and is not accompanied by deficiency-cold syndrome. The whole prescription has the functions of clearing away heat and toxic substances, removing blood stasis, dispersing stagnation and relieving pain.

Description

Technical Field

[0001] The invention relates to a pharmaceutical preparation, in particular to a Huoluo enema soup capable of clearing away heat, detoxifying, removing blood stasis, dispersing stagnation and relieving pain. Background Art

[0002] Enema is a technique in which a certain amount of liquid is poured from the anus through the rectum into the colon to help patients clean the intestines, defecate, pass gas, or supply medicine from the intestines to achieve the purpose of diagnosis and treatment. The characteristics of Chinese medicine enema are high local drug concentration. After the effective ingredients are fully absorbed, they can directly act on the inflammatory target organs, avoiding the first-pass elimination effect of the liver, so that the bioavailability of the drug can be fully utilized. At the same time, it can overcome the shortcomings of fibrous connective tissue hyperplasia caused by chronic inflammation, poor pelvic blood circulation, and difficulty for systemic medication to reach the lesions through the blood circulation. Summary of the invention

[0003] The purpose of the present invention is to provide a kind of active enema soup which can clear away heat, detoxify, dissipate blood stasis, disperse knots and relieve pain according to the existing ones.

[0004] A collateral-activating enema soup for clearing away heat and detoxifying, removing blood stasis, dispersing nodules and relieving pain, characterized in that the prescription of the enema medicine comprises: 20 to 35 grams of Scutellaria barbata, 20 to 35 grams of Hedyotis diffusa, 10 to 20 grams of Gleditsia sinensis, 10 to 25 grams of Curcuma zedoaria, 10 to 25 grams of Paeonia suffruticosa, 10 to 25 grams of Cinnamon twig, 15 to 25 grams of Rhubarb, 20 to 35 grams of Sargassum sutchuenensis, 20 to 35 grams of Sauce Grass, 10 to 25 grams of Corydalis yanhusuo, 10 to 20 grams of Rhizoma Cibotii, and 20 to 35 grams of Luffa. The Hedyotis diffusa and Scutellaria barbata are monarch drugs, and the Spinosa nasutchuenensis, Curcuma zedoaria, Paeonia suffruticosa, Cinnamon twig, Rhubarb, Sparganium lanceolata, Cinnamon twig, and Patrinia patriniae are ministerial drugs, and Corydalis yanhusuo and Luffa sinensis are adjuvant drugs. The preparation and use methods thereof are as follows:

[0005] 2) The enema medicine is prepared by: decocting 300 ml of the enema medicine;

[0006] 2) The method of using the enema medicine is as follows: heat the enema medicine to 37 to 38°C and add it to the enema bag; retain the enema twice, one dose every two days; apply a small amount of paraffin oil to the enema tube, slowly insert the enema tube into the anus along the physiological curvature of the rectum, the insertion depth is about 10-15cm, and the medicine solution is poured in; retain the medicine solution for more than 1 hour to allow the rectal mucosa to fully absorb it

[0007] Beneficial effects: This prescription is suitable for patients with pelvic masses, pelvic inflammatory diseases, pelvic adhesive infertility, endometriosis, adenomyosis, etc. with or without abdominal pain, and the symptoms are damp-heat and blood stasis, without symptoms of deficiency and cold. The whole prescription has the effects of clearing away heat and detoxifying, resolving blood stasis, dispersing nodules and relieving pain. DETAILED DESCRIPTION

[0008] This section will describe specific embodiments of the present invention in detail.

[0009] The medicinal properties and pharmacological effects of the ingredients in this prescription are as follows:

[0010] 1. Scutellaria barbata: pungent, bitter, cold in nature; enters the lung, liver, and kidney meridians. Functions: clearing away heat and detoxifying, removing blood stasis and promoting diuresis. Suitable for treating carbuncle, sore throat, pain from falls, edema, jaundice, snake and insect bites;

[0011] 2. Hedyotis diffusa: slightly bitter, sweet, cold. Enters the stomach, large intestine, and small intestine meridians. Efficacy: clears away heat and detoxifies, promotes dampness and relieves stranguria. Mainly used for carbuncle, sore throat, snake bites, hot stranguria, etc.

[0012] 1) Chemical composition: mainly contains hexadecane, stigmasterol, ursolic acid, oleanolic acid, β-sitosterol, β-sitosterol-D-glucoside, p-coumaric acid, etc.;

[0013] 2) Pharmacological effects: This product has anti-tumor effects. The antibacterial effect in vitro is not significant, and the high-concentration decoction has a weak inhibitory effect on Staphylococcus aureus and Shigella dysenteriae; it can enhance the phagocytic ability of white blood cells in vivo and has anti-inflammatory effects. It also has the effects of inhibiting spermatogenesis and protecting the liver and promoting bile secretion.

[0014] 3. Gleditsia sinensis: pungent and warm in nature; enters the liver and stomach meridians. Functions: reduce swelling, expel toxins, discharge pus, and kill insects. Suitable for carbuncle at the beginning or pus formation without ulceration, and external treatment of scabies, leprosy.

[0015] 4. Curcuma: pungent, bitter, warm. Enters the liver and spleen meridians. Efficacy: breaks blood and promotes qi, eliminates accumulation and relieves pain. Indications: lumps, blood stasis, amenorrhea, chest pain, heart pain, food accumulation, qi stagnation, abdominal distension and pain, etc.

[0016] 1) Chemical composition: mainly contains volatile oils: germacron, curcuma dione, curcumol, curcuma spironolactone, zedoaryl alcohol, gingerol, borneol, curcuma furanone, terpinene, eugenol, etc.; phenolic components: curcumin, etc. The Chinese Pharmacopoeia stipulates that the volatile oil content of this product shall not be less than 1.5% (mL / g), and the decoction piece shall not be less than 1.0% (mL / g);

[0017] 2) Pharmacological effects Curcuma volatile oil preparations have anti-cancer effects. Curcuma volatile oil can inhibit the growth of a variety of pathogenic bacteria; Curcuma oil has anti-inflammatory, anti-gastric ulcer, liver protection and anti-early pregnancy effects. Curcuma water extract can inhibit platelet aggregation, promote micro-arterial blood flow recovery, and promote local microcirculation recovery; Curcuma water extract alcohol precipitation has an inhibitory effect on thrombosis in the body. In addition, Curcuma has a direct inactivation effect on respiratory syncytial virus.

[0018] 5. Peony bark: bitter, pungent, slightly cold. Enters the heart, liver, and kidney meridians. Efficacy: clears heat and cools blood, promotes blood circulation and removes blood stasis. Indications: heat entering the blood, fever caused by warm toxins, vomiting and bleeding due to blood heat; warm evil injuring yin, fever due to yin deficiency, night heat and morning coolness, no sweat and bone steaming; blood stasis, amenorrhea, dysmenorrhea, pain caused by falls and injuries; carbuncle, swelling, and sores.

[0019] 1) Chemical composition: mainly contains paeonol (paeonol), paeonol glycosides, paeonol protoglycosides, paeonol neoglycosides, peony glycosides, oxidized peony glycosides, benzoyl peony glycosides, benzoyl oxidized peony glycosides, etc. It also contains gallic acid, volatile oil, etc. The Chinese Pharmacopoeia stipulates that this product must contain no less than 1.2% paeonol (C 9H 10O 3);

[0020] 2) Pharmacological effects: Paeonol has a significant inhibitory effect on inflammation in various experimental animals, and has an antipyretic effect on fever caused by cholera, typhoid and paratyphoid bacteria, and has a sedative effect; Paeonol total glycosides also have a significant anticonvulsant effect. Paeonia suffruticosa decoction has an inhibitory effect on pathogenic bacteria such as Shigella dysenteriae, Salmonella typhi, Bacillus microsus and various skin fungi. Paeonia suffruticosa extract, paeonol, paeoniflorin, benzoylpeoniflorin, and benzoyloxypeoniflorin can inhibit platelet aggregation and have an antithrombotic effect. In addition, it also has analgesic, anti-allergic, anti-cardiocerebral ischemia, anti-atherosclerosis, anti-arrhythmia, anti-hypertensive, immune regulation, liver protection, kidney protection, and anti-tumor effects.

[0021] 6. Cinnamon twig: pungent, sweet, warm. Enters the heart, lung, and bladder meridians. Efficacy: sweating and relieving muscles, warming and unblocking the meridians, assisting yang and transforming qi, calming the negative energies and relieving adverse reactions. Indications: cold and cold; cold pain in the abdomen, amenorrhea, dysmenorrhea, joint pain, and other pain symptoms caused by cold and blood stasis; phlegm and fluid retention, edema; palpitations, and running pig.

[0022] 1) Chemical composition: mainly contains volatile oils: cinnamaldehyde, camphene, benzaldehyde, β-elemene, β-cuberene, etc. It also contains phenols, organic acids, polysaccharides, glycosides, coumarins and tannins. The Chinese Pharmacopoeia stipulates that the content of cinnamaldehyde (C 9H 8O) in this product shall not be less than 1.0%;

[0023] 2) Pharmacological action The cinnamon oil contained in this product can dilate blood vessels, improve blood circulation, and promote blood flow to the body surface, which is conducive to sweating and heat dissipation. Cinnamon twig decoction and cinnamaldehyde have antipyretic and cooling effects. Cinnamon twig alcohol extract has inhibitory effects on Staphylococcus aureus, Escherichia coli, Pneumococcus, anthrax bacillus, Vibrio cholerae, influenza virus, etc. Cinnamon oil and cinnamaldehyde have inhibitory effects on Mycobacterium tuberculosis and Proteus. Cinnamaldehyde can promote gastrointestinal smooth muscle peristalsis, enhance digestive function, and have a choleretic effect. In addition, cinnamon twig has analgesic, anti-inflammatory, anti-allergic, increased coronary blood flow, improved cardiac function, sedative, anticonvulsant, anti-tumor and other effects.

[0024] 7. Raw rhubarb: bitter, cold. Enters the spleen, stomach, large intestine, liver, and pericardium meridians. Efficacy: purgative, clearing away heat and purging fire, cooling blood and detoxifying, stopping bleeding, removing blood stasis and promoting menstruation, removing dampness and relieving jaundice. Indications: constipation due to excess heat accumulation; vomiting and bleeding due to blood heat, red eyes and swollen throat, swollen and painful gums; carbuncle, furuncle, abdominal pain due to intestinal carbuncle; amenorrhea due to blood stasis, postpartum blood stasis, traumatic injury; damp-heat dysentery, jaundice and red urine, stranguria, edema; burns and scalds.

[0025] 1) Chemical composition: mainly anthraquinone derivatives, including anthraquinone glycosides and dianthraquinone glycosides. Among the dianthraquinone glycosides are sennosides A, B, C, D, E, and F; free aglycones include rhein, chrysophanol, rhein, aloe-emodin, and physophanol methyl ether. It also contains tannins, organic acids, and estrogen-like substances. The Chinese Pharmacopoeia stipulates that the total amount of aloe-emodin (C 15H 10O5), rhein (C 15H 8O 6), rhein (C15H 10O 5), chrysophanol (C 15H 10O 4), and physophanol methyl ether (C16H 12O 5) contained in this product shall not be less than 1.5%;

[0026] 2) Pharmacological action: Rhubarb can increase intestinal motility, inhibit intestinal water absorption, and promote defecation; Rhubarb has anti-infective effects and has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria, among which the most sensitive are Staphylococcus and Streptococcus, followed by diphtheria Corynebacterium, Salmonella typhi and paratyphoid, Pneumococcus, Shigella dysenteriae, etc.; it also has an inhibitory effect on influenza virus; due to tannins, there is constipation after diarrhea; it has choleretic and stomachic effects; in addition, it also has hemostatic, liver-protecting, blood pressure-lowering, and serum cholesterol-lowering effects.

[0027] 8. Red vine: bitter, flat. Enter the large intestine and liver meridians. Efficacy: clearing away heat and detoxifying, promoting blood circulation, dispelling wind and relieving pain. Indications: abdominal pain caused by intestinal carbuncle, ulcer caused by heat toxins; blood stasis, amenorrhea, dysmenorrhea, swelling and pain caused by falls; rheumatic arthralgia.

[0028] 1) Chemical composition: mainly contains anthraquinone components such as rhubarb, rhubarb methyl ether, rhubarb phenol, triterpenes, lignans, sterols and various phenols and phenolic glycosides;

[0029] 2) Pharmacological action: The decoction of this product has a strong inhibitory effect on Staphylococcus aureus and Group B Streptococcus, and also has a certain inhibitory effect on Escherichia coli, Staphylococcus albus, Catarrhalis, Group A Streptococcus and Pseudomonas aeruginosa. The water extract of this product can inhibit platelet aggregation, increase coronary flow, inhibit thrombosis, increase plasma cAMP levels, improve the hypoxia tolerance of experimental animals, dilate coronary arteries, and reduce the scope of myocardial infarction.

[0030] 9. Patrinia scabra: pungent, bitter, slightly cold. Enters the stomach, large intestine, and liver meridians. Efficacy: clears away heat and detoxifies, eliminates carbuncle and discharges pus, removes blood stasis and relieves pain. Mainly used for intestinal carbuncle, lung carbuncle, carbuncle, swelling, and sore; abdominal pain caused by blood stasis after childbirth.

[0031] 1) Chemical composition: Patrinia lutea mainly contains coumarins, iridoids, saponins, sterols, etc. Patrinia leucoderma mainly contains volatile oil, mollorhexidine, strychnoside, and leucoside;

[0032] 2) Pharmacological effects: Patrinia scabra has inhibitory effects on Staphylococcus aureus, Shigella dysenteriae, Salmonella typhi, Pseudomonas aeruginosa, and Escherichia coli. It also has anti-hepatitis virus, liver protection, anti-tumor, and sedative effects.

[0033] 10. Corydalis: pungent, bitter, warm. Enters the liver, spleen, and heart meridians. Efficacy: promotes blood circulation, promotes qi circulation, and relieves pain. It is mainly used to treat qi and blood stasis, chest and flank pain, abdominal pain, chest obstruction and heart pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain due to falls.

[0034] 1) Chemical composition: It mainly contains more than 20 alkaloids such as corydalis acetylcholine, ...

[0035] 2) Pharmacological action: Corydalis A, B and Urocarb have analgesic, hypnotic, sedative and tranquilizing effects. Corydalis ethanol extract can dilate coronary arteries, reduce coronary resistance, increase coronary blood flow, and improve hypoxia tolerance. Corydalis total alkaloids can fight arrhythmias. Dehydrocorydalis A can protect myocardial cells and resist myocardial ischemia. Corydalis B can dilate peripheral blood vessels, lower blood pressure, and has a protective effect on cerebral ischemia-reperfusion injury. Corydalis total alkaloids and ethanol extracts have anti-ulcer effects, and B can inhibit gastric juice secretion. In addition, Corydalis has certain antibacterial, anti-inflammatory, anti-tumor effects and improves anti-stress ability.

[0036] 11. Tripterygium wilfordii: pungent, bitter, neutral. Enters the liver and spleen meridians. Efficacy: breaks blood and promotes qi circulation, eliminates stagnation and relieves pain. Indications: lumps and masses, blood stasis and amenorrhea, chest pain and heartache; food stagnation and qi stagnation, abdominal distension and pain.

[0037] 1) Chemical composition: mainly contains volatile oils: germacron, curcuma dione, curcumol, curcuma spironolactone, zedoaryl alcohol, gingerol, borneol, curcuma furanone, terpinene, eugenol, etc.; phenolic components: curcumin, etc. The Chinese Pharmacopoeia stipulates that the volatile oil content of this product shall not be less than 1.5% (mL / g), and the decoction piece shall not be less than 1.0% (mL / g);

[0038] 2) Pharmacological effects: Curcuma volatile oil preparations have anti-cancer effects. Curcuma volatile oil can inhibit the growth of a variety of pathogenic bacteria; Curcuma oil has anti-inflammatory, anti-gastric ulcer, liver protection and anti-early pregnancy effects. Curcuma water extract can inhibit platelet aggregation, promote micro-arterial blood flow recovery, and promote local microcirculation recovery; Curcuma water extract alcohol precipitation has an inhibitory effect on thrombosis in the body. In addition, Curcuma has a direct inactivation effect on respiratory syncytial virus.

[0039] 12. Luffa: sweet, neutral. Enters the lung, stomach, and liver meridians. Efficacy: dispel wind, dredge meridians, activate blood circulation, and promote lactation. Indications: rheumatic arthralgia, muscle spasm, chest and flank pain, milk blockage, and mastitis.

[0040] 1) Chemical composition: mainly contains xylan, mannan, galactan, etc.;

[0041] 2) Pharmacological effects: Luffa decoction has obvious analgesic, sedative and anti-inflammatory effects.

[0042] The local drug concentration of Chinese medicine enema is high, and the effective ingredients can directly act on the inflammatory target organs after being fully absorbed, avoiding the first-pass elimination effect of the liver, so that the bioavailability of the drug can be fully exerted. At the same time, it can overcome the shortcomings of fibrous connective tissue hyperplasia due to chronic inflammation, poor pelvic blood circulation, and difficulty in systemic medication to reach the lesions through the blood circulation. The main ingredients are Houttuynia cordata and Scutellaria barbata for clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. Gleditsia sinensis and Curcuma zedoaria for removing blood stasis and dispersing nodules. On the basis of the original formula, Paeonia suffruticosa, cinnamon twig, rhubarb, Trillium, Scutellaria baicalensis, and Patrinia chinensis are added to enhance the effects of clearing heat, promoting blood circulation, removing blood stasis and relieving pain. They are all ministerial drugs. Corydalis yanhusuo and luffa fructus for promoting qi, relieving pain and dredging collaterals are all adjuvant drugs.

[0043] The above is a detailed description of the embodiments of the present invention, but the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. A Huoluo enema soup for clearing away heat and detoxifying, removing blood stasis, dispersing stagnation and relieving pain, characterized by: The prescription of the enema medicine includes: 20 to 35 grams of Scutellaria barbata, 20 to 35 grams of Hedyotis diffusa, 10 to 20 grams of Gleditsia sinensis, 10 to 25 grams of Curcuma zedoaria, 10 to 25 grams of Paeonia suffruticosa, 10 to 25 grams of Cassia twig, 15 to 25 grams of Raw Rhubarb, 20 to 35 grams of Red Caulis, 20 to 35 grams of Sauce Herb, 10 to 25 grams of Corydalis yanhusuo, 10 to 20 grams of Rhizoma Cibotii, and 20 to 35 grams of Luffa.

2. The Huoluo Enema Decoction for clearing away heat and detoxifying, removing blood stasis, dispersing nodules and relieving pain according to claim 1, characterized in that: The herb is mainly composed of the following: Herba Hedyotis diffusae and Scutellaria barbata are the main drugs, Gleditsia sinensis, Rhizoma Curcumae, Cortex Moutan, Cinnamomum cassiae, Rhubarb, Rhizoma Trigonosciae, Caulis Sargentodoxae and Herba Patriniae are the assistant drugs, and Corydalis yanhusuo and Luffa fructus are the adjuvant drugs.

3. The Huoluo enema soup for clearing away heat, detoxifying, removing blood stasis, dispersing nodules and relieving pain according to claim 1, characterized in that The preparation and use methods are: 1) The preparation method of the enema medicine is as follows: decocting 300 ml of the enema medicine water; 2) The method of using the enema medicine is as follows: heat the enema medicine to 37 to 38° C. and add it to an enema bag; retain the enema twice, one dose every two days; apply a small amount of paraffin oil to the enema tube, slowly insert the enema tube into the anus along the physiological curvature of the rectum, the insertion depth is about 10-15 cm, and the medicine solution is poured in; retain the medicine solution for more than 1 hour to allow the rectal mucosa to fully absorb it.