A non-woven dressing and a preparation method thereof

Abstract

The present invention discloses a non-woven dressing and a preparation method thereof, and relates to the technical field of non-woven dressings, including a non-woven dressing, including a non-woven layer, wherein the non-woven layer is made by mixing calcium alginate fiber and silk fiber by a hydroentanglement method, and the surface of the non-woven layer is immersed in a liquid medicine, and then dried and cut. A preparation method of a non-woven dressing comprises the following steps: S1: firstly, sodium alginate is dissolved in water to prepare a sodium alginate solution, and then calcium chloride is dissolved in water to prepare a coagulation bath, and after the coagulation bath is prepared, the sodium alginate solution is extruded through a spinneret hole into a coagulation bath containing calcium chloride, which can achieve antibacterial effects while affecting angiogenesis of wounds, epithelialization of wound surfaces, etc., and can also significantly and effectively promote wound healing, and has high moisturizing properties and high air permeability.

Description

Technical Field

[0001] The invention relates to the technical field of non-woven dressings, in particular to a non-woven dressing and a preparation method thereof. Background Art

[0002] Skin is the largest organ of the human body. People will inevitably encounter various wounds in their daily life. Using dressings to cover exposed wounds is a common method of wound care in clinical practice. The most widely used dressing is the traditional cotton gauze. However, with the development of science and technology and the improvement of living standards, people have put forward higher requirements for medical dressings. Traditional cotton gauze can no longer meet the actual needs. It is increasingly replaced by new medical dressings, such as new medical dressings that contain silver ions to obtain antibacterial effects.

[0003] Current medical dressings have a single function and it is difficult to effectively achieve antibacterial effects while also having effects on wound angiogenesis and wound epithelialization. They are also unable to significantly and effectively promote wound healing and have poor moisturizing properties. To this end, we propose a non-woven dressing and a preparation method thereof. Summary of the invention

[0004] The technical problem to be solved by the present invention is to overcome the existing defects and provide a non-woven dressing and a preparation method thereof, which can have an effect on angiogenesis, wound epithelialization and other aspects of the wound while achieving antibacterial properties, and can also significantly and effectively promote wound healing, and has high moisturizing properties and high air permeability, which can effectively solve the problems in the background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a non-woven dressing, comprising a non-woven fabric layer, wherein the non-woven fabric layer is made by mixing calcium alginate fiber and silk fiber by hydroentanglement, and the surface of the non-woven fabric layer is immersed in a medicinal solution and then dried and cut.

[0006] A method for preparing the non-woven dressing as claimed in claim 1, comprising the following steps:

[0007] S1: firstly, sodium alginate is dissolved in water to prepare a sodium alginate solution, and then calcium chloride is dissolved in water to prepare a coagulation bath. After the coagulation bath is prepared, the sodium alginate solution is extruded through a spinneret into a coagulation bath containing calcium chloride to form solid insoluble calcium alginate filaments. The spun fibers are then subjected to processes such as washing, drawing, and shaping to prepare calcium alginate fibers. By using calcium alginate fibers, the overall biodegradability of the non-woven dressing can be improved, and at the same time, the non-woven dressing has high oxygen permeability, which is helpful for wound healing, and has bactericidal and antibacterial properties, thereby reducing the risk of infection.

[0008] S2: Select the cocoon shell with neat cocoon shape, uniform cocoon layer thickness, basically consistent cocoon color and no defects on the surface, then place the cocoon shell inside the alkaline degumming agent for stirring and heating. Under alkaline conditions, sericin will absorb water and swell, and then dissolve or soften, thereby separating from the silk. The silk is washed with hot water to remove the residual degumming agent, and then dried to obtain pure silk fibroin. The pure silk fibroin is then dissolved in an appropriate solvent to prepare a spinning solution, and then the spinning solution is spun in a coagulation bath to form primary silk fibroin fibers. The primary silk fibroin fibers are then treated with a drawing solution, and the drawn fibers are heat-set after treatment to obtain silk fibers. By using silk limiters, the non-woven dressing has higher strength and good flexibility, and the antibacterial and anti-inflammatory functions of the non-woven dressing can be further improved, which is helpful for wound healing.

[0009] S3: mixing the calcium alginate fiber prepared in step S1 and the silk fiber prepared in step S2, and performing a cotton cleaning process to remove impurities and short fibers, and then combing the fibers into a single fiber state through a carding machine to form a uniform fiber web;

[0010] S4: sending the carded fiber web into a spunlace machine, and using high-pressure water flow to spray and impact the fiber web, so that the fibers are entangled with each other, and then the fiber web reinforced by spunlace enters a drying stage to remove excess water, and then performs a softening treatment and an antibacterial treatment to obtain a non-woven fabric base fabric;

[0011] S5: chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe extract, tea tree oil, coptis extract, gelatin, glycerin and lavender flavor are mixed and stirred to make a liquid medicine. By using chitosan, the antibacterial, hemostatic and wound healing effects of the non-woven dressing can be improved. By using epidermal growth factor, the strong promotion of cell proliferation and tissue repair of the non-woven dressing can be improved. By using hyaluronic acid, the non-woven dressing can maintain the moisture of the user's skin and increase the lubricity and elasticity of the non-woven dressing. By using vitamin C, it is helpful for collagen synthesis and wound healing. By using aloe extract, the non-woven dressing has a calming and soothing performance, and can further improve the antibacterial effect and moisturizing function. By using tea tree oil, it is helpful to prevent infection and reduce inflammation. By using coptis extract, the non-woven dressing has the effects of clearing away heat and dampness, purging fire and detoxifying. By using, the stability and adhesion of the non-woven dressing can be improved. By using glycerin, the skin can be further helped to maintain moisture. By using lavender flavor, the user's comfort can be improved.

[0012] S6: soaking the non-woven fabric base fabric obtained in step S4 in the drug solution prepared in step S5, and then drying the soaked non-woven fabric, and cutting the non-woven fabric base fabric after drying to obtain a non-woven dressing.

[0013] Furthermore, the mass percentage of sodium alginate in the sodium alginate solution in step S1 is 3%-8%.

[0014] Furthermore, in step S1, the mass percentage of calcium chloride concentration is 2%-5%, the spinning temperature is controlled between 15° C.-30° C., and the drawing rate is 30%-50%.

[0015] Furthermore, in step S2, the alkaline degumming agent may be selected from one of sodium carbonate, sodium bicarbonate and strong alkaline electrolyzed water, and the temperature during the degumming process is controlled at 95° C.-98° C.

[0016] Furthermore, in step S2, the solvent for dissolving the pure silk fibroin is a CaCl2 solution, and stirring is required during the dissolution, and the stirring speed is controlled at 200 r / min.

[0017] Furthermore, in step S2, the stretching bath is selected to be an ethanol solution with a mass fraction of 50%.

[0018] Furthermore, in step S2, the coagulation bath is selected from one of sulfuric acid, sodium sulfate and sulfuric acid.

[0019] Furthermore, the content ratio of chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe extract, tea tree oil, coptis extract, gelatin, glycerin and lavender flavor in the medicinal solution prepared in step S5 is 10:1:5:2:10:3:5:5:8:10:1.

[0020] Furthermore, the soaking time in BU step S6 is overnight, and the drying method can be natural drying, hot air drying or vacuum drying.

[0021] Compared with the prior art, the present invention has the following beneficial effects: the non-woven dressing and the preparation method thereof have the following advantages:

[0022] 1. The non-woven fabric layer made of calcium alginate fiber and silk fiber makes the non-woven dressing have high biodegradability and high oxygen permeability, which is helpful for wound healing. It also has bactericidal and antibacterial properties, reducing the risk of infection. It also has anti-stretching properties to prevent the non-woven dressing from tearing.

[0023] 2. The use of epidermal growth factor can enhance the ability of non-woven dressings to promote cell proliferation and tissue repair. The use of hyaluronic acid can enable non-woven dressings to retain moisture in the user's skin while increasing the lubricity and elasticity of non-woven dressings. The use of vitamin C can help collagen synthesis and wound healing. The use of aloe vera extract can give non-woven dressings a calming and soothing effect while further improving the antibacterial effect and moisturizing function.

[0024] 3. The use of tea tree oil helps prevent infection and relieve inflammation. The use of Coptis chinensis extract makes the non-woven dressing have the effects of clearing away heat and dampness, purging fire and detoxifying. The use of can improve the stability and adhesion of non-woven dressings. The use of glycerin can further help the skin retain moisture. The use of lavender fragrance can improve the user's comfort. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] This embodiment provides a technical solution: a non-woven dressing, including a non-woven fabric layer, wherein the non-woven fabric layer is made by mixing calcium alginate fibers and silk fibers by hydroentanglement, and the surface of the non-woven fabric layer is immersed in a medicinal solution and then dried and cut.

[0027] A method for preparing the non-woven dressing as claimed in claim 1, comprising the following steps:

[0028] S1: firstly, dissolve sodium alginate in water to prepare sodium alginate solution, then dissolve calcium chloride in water to prepare a coagulation bath, after the coagulation bath is prepared, extrude the sodium alginate solution through a spinneret hole into a coagulation bath containing calcium chloride to form solid insoluble calcium alginate filaments, and then the spun fibers are subjected to processes such as washing, drawing, and shaping to prepare calcium alginate fibers. By using calcium alginate fibers, the overall biodegradability of the non-woven dressing can be improved, and the non-woven dressing can have high oxygen permeability, which is helpful for wound healing, and has bactericidal and antibacterial properties, reducing the risk of infection. The mass percentage of sodium alginate in the sodium alginate solution is 3%-8%, the mass percentage of calcium chloride concentration is 2%-5%, the spinning temperature is controlled between 15°C-30°C, and the drawing rate is 30%-50%;

[0029] S2: Select the cocoon shell with neat shape, uniform thickness of cocoon layer, basically uniform cocoon color and no defects on the surface, then place the cocoon shell inside the alkaline degumming agent for stirring and heating. Under alkaline conditions, sericin will absorb water and swell, and then dissolve or soften, thereby separating from the silk. The silk is washed with hot water to remove the residual degumming agent, and then dried to obtain pure silk fibroin. The pure silk fibroin is then dissolved in an appropriate solvent to prepare a spinning solution, and then the spinning solution is spun in a coagulation bath to form primary silk fibroin fibers, and then through Treating the nascent silk fibroin with a drawing liquid, and then performing a heat setting treatment on the drawn fiber to obtain the silk fiber, the alkaline degumming agent can be selected from one of sodium carbonate, sodium bicarbonate and strong alkaline electrolyzed water, the temperature during the degumming process is controlled at 95° C.-98° C., the solvent for dissolving the pure silk fibroin is selected from a CaCl2 solution, stirring is required during the dissolution, and the stirring speed is controlled at 200 r / min, the drawing bath is selected from an ethanol solution with a mass fraction of 50%, and the coagulation bath is selected from one of sulfuric acid, sodium sulfate and sulfuric acid;

[0030] By using silk limiters, non-woven dressings have higher strength and good flexibility, and can further improve the antibacterial and anti-inflammatory functions of non-woven dressings, which helps wound healing;

[0031] S3: mixing the calcium alginate fiber prepared in step S1 and the silk fiber prepared in step S2, and performing a cotton cleaning process to remove impurities and short fibers, and then combing the fibers into a single fiber state through a carding machine to form a uniform fiber web;

[0032] S4: sending the carded fiber web into a spunlace machine, and using high-pressure water flow to spray and impact the fiber web, so that the fibers are entangled with each other, and then the fiber web reinforced by spunlace enters a drying stage to remove excess water, and then performs a softening treatment and an antibacterial treatment to obtain a non-woven fabric base fabric;

[0033] S5: mixing chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe vera extract, tea tree oil, coptis chinensis extract, gelatin, glycerin and lavender flavoring agent to prepare a liquid medicine, wherein the content ratio of chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe vera extract, tea tree oil, coptis chinensis extract, gelatin, glycerin and lavender flavoring agent in the liquid medicine is 10:1:5:2:10:3:5:5:8:10:1;

[0034] The use of chitosan can improve the antibacterial, hemostatic and wound healing effects of non-woven dressings. The use of epidermal growth factor can improve the strong promotion of cell proliferation and tissue repair of non-woven dressings. The use of hyaluronic acid can make non-woven dressings able to maintain user skin moisture and increase the lubricity and elasticity of non-woven dressings. The use of vitamin C helps collagen synthesis and wound healing. The use of aloe vera extract can make non-woven dressings have sedative and soothing properties, and can further improve the antibacterial effect and moisturizing function. The use of tea tree oil can help prevent infection and reduce inflammation. The use of Coptis chinensis extract can make non-woven dressings have the effects of clearing away heat and dampness, purging fire and detoxifying. The use of can improve the stability and adhesion of non-woven dressings. The use of glycerin can further help the skin retain moisture. The use of lavender fragrance can improve the user's comfort.

[0035] S6: soaking the non-woven fabric base fabric obtained in step S4 in the drug solution prepared in step S5, and then drying the soaked non-woven fabric, and cutting the non-woven fabric base fabric after drying to obtain a non-woven dressing.

[0036] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention specification, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A non-woven dressing, characterized in that: The non-woven fabric layer comprises a non-woven fabric layer, wherein the non-woven fabric layer is made by mixing calcium alginate fiber and silk fiber through a water spunlace method, and the surface of the non-woven fabric layer is immersed in a medicine solution and then dried and cut.

2. A method for preparing the non-woven dressing according to claim 1, characterized in that: The following steps are involved: S1: firstly dissolving sodium alginate in water to prepare a sodium alginate solution, then dissolving calcium chloride in water to prepare a coagulation bath, after the coagulation bath is prepared, extruding the sodium alginate solution through a spinneret into a coagulation bath containing calcium chloride to form a solid insoluble calcium alginate filament, and then the spun fiber is subjected to processes such as washing, drawing, and shaping to obtain calcium alginate fiber; S2: Selecting an upper cocoon shell with a neat cocoon shape, uniform cocoon layer thickness, basically uniform cocoon color, and no surface defects, and then placing the cocoon shell inside an alkaline degumming agent for stirring and heating. Under alkaline conditions, sericin will absorb water and swell, and then dissolve or soften, thereby separating from the silk. The silk is washed with hot water to remove the residual degumming agent, and then dried to obtain pure silk fibroin. The pure silk fibroin is then dissolved in an appropriate solvent to prepare a spinning solution, and then the spinning solution is spun in a coagulation bath to form primary silk fibroin fibers. The primary silk fibroin fibers are then treated with a drawing solution, and after treatment, the drawn fibers are subjected to a heat setting treatment to obtain silk fibers. S3: mixing the calcium alginate fiber prepared in step S1 and the silk fiber prepared in step S2, and performing a cotton cleaning process to remove impurities and short fibers, and then combing the fibers into a single fiber state through a carding machine to form a uniform fiber web; S4: sending the carded fiber web into a spunlace machine, and using high-pressure water flow to spray and impact the fiber web, so that the fibers are entangled with each other, and then the fiber web reinforced by spunlace enters a drying stage to remove excess water, and then performs a softening treatment and an antibacterial treatment to obtain a non-woven fabric base fabric; S5: mixing chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe vera extract, tea tree oil, coptis root extract, gelatin, glycerin and lavender flavoring agent to prepare a liquid medicine; S6: soaking the non-woven fabric base fabric obtained in step S4 in the drug solution prepared in step S5, and then drying the soaked non-woven fabric, and cutting the non-woven fabric base fabric after drying to obtain a non-woven dressing.

3. A non-woven dressing and a preparation method thereof according to claim 2, characterized in that: The mass percentage of sodium alginate in the sodium alginate solution in step S1 is 3%-8%.

4. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S1, the mass percentage of calcium chloride concentration is 2%-5%, the spinning temperature is controlled between 15° C.-30° C., and the drawing rate is 30%-50%.

5. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S2, the alkaline degumming agent can be selected from sodium carbonate, sodium bicarbonate and strong alkaline electrolyzed water, and the temperature during the degumming process is controlled at 95° C.-98° C.

6. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S2, the solvent for dissolving pure silk fibroin is a CaCl2 solution, which needs to be stirred during the dissolution, and the stirring speed is controlled at 200 r / min.

7. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S2, the stretching bath is selected to be an ethanol solution with a mass fraction of 50%.

8. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S2, the coagulation bath is selected from one of sulfuric acid, sodium sulfate and sulfuric acid.

9. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: The content ratio of chitosan, epidermal growth factor, hyaluronic acid, vitamin C, aloe extract, tea tree oil, coptis extract, gelatin, glycerin and lavender flavor in the medicinal solution prepared in step S5 is 10:1:5:2:10:3:5:5:8:10:

1.

10. A non-woven dressing and a preparation method thereof according to claim 1, characterized in that: In step S6, the soaking time is overnight, and the drying method can be natural drying, hot air drying or vacuum drying.