A heparin sodium extraction device

Abstract

The present invention relates to the technical field of sodium heparin extraction equipment, and specifically to a sodium heparin extraction device, comprising an extraction barrel, a stirring and mixing component, a connecting frame, an extraction component and a driving component, wherein the extraction barrel has a mixing chamber arranged vertically; the stirring and mixing component has a stirring main shaft, and a stirring portion is arranged on the outer wall of the stirring main shaft; the connecting frame is fixed in the mixing chamber and has a feeding channel; the extraction component includes at least two groups of extraction units, and the extraction units are fixedly mounted on the connecting frame by rotation; the driving component is fixedly connected to the extraction barrel and has at least two groups of driving ends. The present invention realizes part of the sodium heparin extraction process through the cooperation of the extraction component and the stirring and mixing component, and ensures the extraction quality of sodium heparin; at the same time, by adding a plurality of groups of extraction units arranged vertically in the mixing chamber, the reaction resin can be evenly arranged in the mixing chamber, ensuring the full exchange of the reaction resin and improving the adsorption efficiency of the resin.

Description

Technical Field

[0001] The invention relates to the technical field of heparin sodium extraction equipment, in particular to a heparin sodium extraction device. Background Art

[0002] Heparin sodium is an anticoagulant agent, which is mainly extracted from the small intestinal mucosa of pigs and sheep.

[0003] In the production process of sodium heparin, after the primary treatment of the small intestinal mucosa of pigs and sheep, the small intestinal mucosa of pigs and sheep is usually stirred into a shredded state by a stirring device, and then trypsin, weak alkaline solution and other preparations are added to form a primary stock solution, and then resin is added for adsorption reaction, and finally the resin is eluted to obtain sodium heparin eluate. In the prior art, the resin is directly poured into the stirring tank for adsorption treatment, but due to the high viscosity of the shredded sodium heparin raw material, the resin is easily precipitated at the bottom of the tank, and the adsorption reaction between the exchange resin and sodium heparin is affected, reducing the adsorption efficiency of the exchange resin. Summary of the invention

[0004] In view of this, the purpose of the present invention is to provide a sodium heparin extraction device to solve the problem that the resin is easily precipitated at the bottom of the tank, the adsorption reaction between the exchange resin and sodium heparin is affected, and the adsorption efficiency of the exchange resin is reduced.

[0005] Based on the above purpose, the present invention provides a heparin sodium extraction device, comprising an extraction barrel having a mixing chamber arranged vertically, wherein the outer wall of the extraction barrel is provided with a liquid inlet pipe and a liquid outlet pipe connected to the mixing chamber; a stirring and mixing component having a stirring main shaft installed in the mixing chamber by a rotational connection, and a stirring portion is provided on the outer wall of the stirring main shaft; a connecting frame fixed in the mixing chamber, and having a feeding channel connected to the outside; an extraction component, comprising at least two groups of extraction units arranged vertically in sequence, wherein the extraction units are all fixedly installed on the connecting frame by a rotational manner, and the extraction unit is annular in structure, and an extraction channel is provided in the extraction unit to vertically penetrate the extraction unit, and the moving path of the extraction channel passes through the feeding channel, and the connection between the two groups of extraction channels and the feeding channel is controlled by the rotation of the extraction unit, and the extraction unit has an exchange flow channel penetrating the inner and outer walls of the extraction unit, and the exchange flow channel is connected to the extraction channel; a driving component fixedly connected to the extraction barrel, and having at least two groups of driving ends, wherein the driving ends are drivingly connected to the corresponding extraction units and are used to drive the extraction units to rotate.

[0006] In an optional example, the extraction unit includes a unit shell, which is provided with several groups of extraction chambers in an arc shape with the center line of the unit shell as the center, and the extraction chambers are combined to form an extraction channel. The extraction chamber is provided with several inner circle through grooves at one end facing the inner circle of the unit shell, and inner circle partition nets are fixed in the inner circle through grooves. The extraction chamber is provided with several outer circle through grooves at one end facing the outer circle of the unit shell, and outer circle partition nets are fixed in the outer circle through grooves. One inner circle through groove and one outer circle through groove are both connected to the corresponding extraction chamber, and the inner circle partition net and the outer circle partition net are combined to form an exchange flow channel.

[0007] In an optional example, the outer ring diameter of the unit shell is smaller than the inner wall diameter of the mixing chamber, the unit shell divides the mixing chamber into an external chamber and an internal chamber, and the stirring part is arranged in the internal chamber.

[0008] In an optional example, the connecting frame includes at least two groups of support frames fixedly connected vertically in sequence and a plurality of support rods for connecting the support frames, a middle partition is fixed to the bottom of the support frame, a middle through groove penetrating the middle partition is provided on the middle partition, an upper partition is fixed to the upper end of the top support frame, an upper through groove penetrating the upper partition is provided on the top of the upper partition.

[0009] In an optional example, a discharge piece is also fixed in the mixing chamber, a discharge pipe extending out of the mixing chamber is arranged at the bottom of the discharge piece, the top of the discharge piece is connected to the middle partition of the bottom support frame, a discharge trough is opened on the top of the discharge piece, and the middle through groove is connected to the discharge trough and the discharge pipe.

[0010] In an optional example, a guide member is provided at the top of the mixing chamber, a guide groove is provided in the guide member, a feeding pipe connected to the mixing chamber is provided at the top of the extraction barrel, one end of the guide groove is connected to the feeding pipe, and the other end of the guide groove is connected to the upper through groove, and the upper through groove, the middle through groove, the discharge trough and the discharge pipe are combined to form a feeding channel.

[0011] In an optional example, an extraction through groove penetrating through the unit shell is provided at the bottom of the extraction chamber, and the extraction through groove can be connected to the middle through groove.

[0012] In an optional example, the drive assembly includes at least two groups of drive motors, the drive end includes a drive shaft and a drive gear, the drive motor is fixedly connected to the extraction barrel, the drive shaft is connected to the connecting frame by rotation, the upper end of the drive shaft extends out of the mixing chamber and is fixedly connected to a group of output shafts of the drive motor, the drive gear is fixedly connected to the drive shaft and is arranged in the mixing chamber, and a plurality of driven teeth are arranged in a circle on the outer wall of the unit shell with the rotation center line of the unit shell as the center, and the drive gear is meshed with the driven teeth.

[0013] In an optional example, the extraction barrel includes a lower barrel body and an upper barrel body connected to each other, a thermal insulation interlayer is fixed on the outer wall of the lower barrel body, a temperature control component is arranged in the thermal insulation interlayer, and the temperature control component is in conflict with the upper barrel body.

[0014] In an optional example, the stirring and mixing assembly further includes a stirring motor fixed outside the extraction barrel, and the upper end of the stirring main shaft extends out of the mixing chamber and is drivingly connected to the output shaft of the stirring motor.

[0015] The beneficial effects of the present invention are that part of the process of sodium heparin extraction is realized by the cooperation of the extraction component and the stirring and mixing component, and the extraction quality of sodium heparin is guaranteed. Meanwhile, by adding a plurality of groups of extraction units arranged vertically in the mixing chamber, the reaction resin can be evenly arranged in the mixing chamber, and it is guaranteed that the reaction resin can be fully exchanged with the sodium heparin raw material, and the adsorption efficiency of the resin is improved. Moreover, by adding a plurality of groups of extraction chambers, the reaction resin can have enough expansion space after adsorption, and the reaction resin is avoided from being squeezed and broken after excessive expansion, so that the reaction resin can be reused, the extraction cost of sodium heparin is reduced, and the service life of the reaction resin is further improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 It is a front view of an embodiment of the present invention;

[0018] Figure 2 It is a schematic diagram of the three-dimensional structure of an embodiment of the present invention;

[0019] Figure 3 is a cross-sectional view of an embodiment of the present invention;

[0020] Figure 4 It is a schematic diagram of the explosion structure of an embodiment of the present invention;

[0021] Figure 5 It is a schematic diagram of the explosion structure of the extraction unit in an embodiment of the present invention;

[0022] Figure 6 is a schematic diagram of the three-dimensional structure of a unit housing in an embodiment of the present invention;

[0023] Figure 7 Schematic diagram of the three-dimensional structure of the mixing chamber in an embodiment of the present invention;

[0024] Figure 8 It is a schematic diagram of the exploded structure of the connection frame in an embodiment of the present invention;

[0025] Fig. 9 It is a schematic diagram of the three-dimensional structure of the unloading member in the embodiment of the present invention.

[0026] The markings in the figure are: 1. extraction barrel; 101. mixing chamber; 1011. external chamber; 1012. internal chamber; 102. liquid inlet pipe; 103. liquid outlet pipe; 104. feeding pipe; 11. lower barrel body; 12. upper barrel body; 13. thermal insulation interlayer; 14. temperature control component; 2. stirring and mixing component; 21. stirring main shaft; 22. stirring part; 23. stirring motor; 3. connecting frame; 301. feeding channel; 302. rotating groove; 31. supporting frame; 32. supporting rod; 33. middle partition; 331. middle through groove; 34. upper partition; 341. Upper through groove; 4. Extraction component; 41. Extraction unit; 411. Extraction channel; 4111. Extraction chamber; 4112. Inner ring through groove; 4113. Outer ring through groove; 4114. Extraction through groove; 4115. Driven gear; 412. Exchange flow channel; 413. Inner ring spacer; 414. Outer ring spacer; 5. Drive component; 51. Drive end; 511. Drive shaft; 512. Drive gear; 52. Drive motor; 6. Discharge part; 62. Discharge chute; 61. Discharge pipe; 621. Inclined part; 622. Discharge part; 7. Guide part; 71. Guide groove. DETAILED DESCRIPTION

[0027] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with specific embodiments.

[0028] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in the present invention should be understood by people with ordinary skills in the field to which the present invention belongs. The "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0029] In one embodiment, see Figures 1 to 4 As shown, a heparin sodium extraction device provided by the present invention comprises: an extraction barrel 1, a stirring and mixing component 2, a connecting frame 3, an extraction component 4 and a driving component 5.

[0030] The extraction barrel 1 has a mixing chamber 101 arranged vertically, and an inlet pipe 102 and an outlet pipe 103 connected to the mixing chamber 101 are arranged on the outer wall of the extraction barrel 1. The raw material mixed liquid for extracting heparin sodium flows into the mixing chamber 101 through the inlet pipe 102, and the outlet pipe 103 is used to discharge the waste liquid after extraction. External control valves are fixed on the inlet pipe 102 and the outlet pipe 103.

[0031] The stirring and mixing assembly 2 has a stirring main shaft 21 installed in the mixing chamber 101 by means of a bearing connection, and a stirring portion 22 is provided on the outer wall of the stirring main shaft 21. The stirring main shaft 21 rotates to drive the stirring portion 22 to rotate, and the raw material mixed liquid for extracting heparin sodium can be fully stirred to meet the reaction requirements.

[0032] The connecting frame 3 is fixed in the mixing chamber 101 and has a feeding channel 301 communicating with the outside. The reaction resin for extracting sodium heparin enters the mixing chamber 101 through the feeding channel 301, and both ends of the feeding channel 301 are fixed to control the control valves communicating with the outside.

[0033] The extraction component 4 includes at least two groups of extraction units 41 arranged vertically in sequence. The connecting frame 3 has a rotating groove 302 matching the extraction unit 41. The extraction unit 41 is rotatably inserted in the rotating groove 302. The extraction unit 41 has an annular structure. An extraction channel 411 is provided in the extraction unit 41 and vertically penetrates the extraction unit 41. The moving path of the extraction channel 411 passes through the feeding channel 301, and the connection between the two groups of extraction channels 411 and the feeding channel 301 is controlled by the rotation of the extraction unit 41. The extraction unit 41 has an exchange flow channel 412 penetrating the inner and outer walls of the extraction unit 41, and the exchange flow channel 412 is connected to the extraction channel 411. Among them, the extraction channel 411 is used to accommodate the reaction resin, the reaction resin is fed into the extraction channel 411 through the feeding channel 301, and the heparin sodium raw material is exchanged with the reaction resin anion through the exchange channel 412; both ends of the feeding channel 301 are fixed with external control valves; the extraction unit 41 can adopt two groups, three groups, etc., and it is preferred to adopt two groups of extraction units 41, which has the advantages of relatively simple structure and low manufacturing cost.

[0034] The driving assembly 5 is fixedly connected to the extraction barrel 1 and has at least two sets of driving ends 51, which are drivingly connected to the corresponding extraction units 41 and are used to drive the extraction units 41 to rotate. The driving ends 51 can be two or three sets, and preferably two sets of driving ends 51 are used, which has the advantages of relatively simple structure and low manufacturing cost.

[0035] Specifically, in this example, the heparin sodium raw material flows into the mixing chamber 101 through the liquid inlet pipe 102, and the stirring main shaft 21 rotates to drive the stirring part 22 to move. The stirring part 22 stirs the heparin sodium raw material into a paste, and then adds trypsin, weak alkali solution and other preparations. The extraction barrel 1 is heated to make the heparin sodium raw material reach a set temperature and maintain it for a certain time, and then the reaction resin is added from the feeding channel 301 to the extraction channel 411 until the feeding is completed. At this time, the stirring main shaft 21 continues to rotate, and similarly drives the heparin sodium raw material Flow, accelerate the flow of heparin sodium raw material along the exchange flow channel 412, wait for a period of time to complete the anion exchange of the reaction resin, open the external control valve on the liquid outlet pipe 103, the waste liquid is discharged from the liquid outlet pipe 103, the reaction resin is discharged through the feeding channel 301, and sodium chloride solution is added from the liquid inlet pipe 102, the temperature is maintained at 50-55°C, the reaction resin is slowly washed, the eluent is discharged from the liquid outlet pipe 103, and collected for subsequent process operations, and finally the reaction resin is discharged from the lower end of the feeding channel 301.

[0036] In summary, this example realizes part of the process of sodium heparin extraction by cooperating with the extraction component 4 and the stirring and mixing component 2, thereby ensuring the extraction quality of sodium heparin. At the same time, by adding a plurality of groups of extraction units 41 arranged vertically in the mixing chamber 101, the reaction resin can be evenly arranged in the mixing chamber 101, thereby ensuring that the reaction resin can be fully exchanged with the sodium heparin raw material, thereby improving the adsorption efficiency of the resin, avoiding the reaction resin from being precipitated in the mixing chamber 101 and reducing the exchange efficiency of the reaction resin, and the extraction unit 41 can isolate the stirring part 22 from direct contact with the resin, thereby avoiding the reaction resin from being broken by the impact of the stirring part 22, thereby improving the service life of the reaction resin and reducing the extraction cost of sodium heparin.

[0037] As an alternative example, see Figures 1 to 6 As shown, in order to further improve the service life of the reaction resin, the extraction unit 41 includes a unit shell, and the unit shell is provided with a plurality of groups of extraction chambers 4111 in an arc shape with the center line of the unit shell as the center. The extraction chambers 4111 are combined to form an extraction channel 411, and the extraction chamber 4111 is provided with a plurality of inner circle through grooves 4112 at one end toward the inner circle of the unit shell, and an inner circle partition net 413 is fixed in the inner circle through groove 4112 by welding, and the extraction chamber 4111 is provided with a plurality of outer circle through grooves 4113 at one end toward the outer circle of the unit shell, and an outer circle partition net 414 is fixed in the outer circle through groove 4113 by welding, an inner circle through groove 4112 and an outer circle through groove 4113 are both connected to the corresponding extraction chamber 4111, and the inner circle partition net 413 and the outer circle partition net 414 are combined to form an exchange flow channel 412.

[0038] Specifically, this example adds several groups of extraction chambers 4111 to allow the reaction resin to have sufficient expansion space after adsorption, thereby avoiding squeezing and crushing of the reaction resin after excessive expansion, allowing the reaction resin to be reused, reducing the extraction cost of sodium heparin, and further increasing the service life of the reaction resin.

[0039] As an alternative example, see Figures 1 to 7 As shown, in order to further improve the exchange efficiency of the reaction resin, the outer ring diameter of the unit shell is smaller than the inner wall diameter of the mixing chamber 101 , and the unit shell separates the mixing chamber 101 into an outer chamber 1011 and an inner chamber 1012 , and the stirring part 22 is disposed in the inner chamber 1012 .

[0040] Specifically, in this example, when the sodium heparin raw material flows, a flowable channel is formed through the internal cavity 1012, the exchange channel 412 and the external cavity 1011, which can accelerate the flow of the sodium heparin raw material. At the same time, the stirring part 22 can rotate in the internal cavity 1012, so that the sodium heparin raw material can fully contact with the reaction resin, further improving the exchange efficiency of the reaction resin.

[0041] As an alternative example, see Figures 1 to 8 As shown, in order to further improve the service life of the reaction resin, the connecting frame 3 includes at least two groups of support frames 31 fixedly connected vertically in sequence and a plurality of support rods 32 for connecting the support frames 31, a middle partition 33 is fixed to the bottom of the support frame 31, a middle through groove 331 penetrating the middle partition 33 is provided on the middle partition 33, an upper partition 34 is fixed to the upper end of the top support frame 31 by bolt connection, and an upper through groove 341 penetrating the upper partition 34 is provided on the top of the upper partition 34. Among them, the support rod 32 is connected to the support frame 31 by bolts; the support frame 31 and the middle partition 33 adopt an integral structure; the middle partition 33 is in conflict with the unit shell and is used to limit the passage of the reaction resin; the upper partition 34 is in conflict with the upper end of the top unit shell, limiting the reaction resin from flowing out of the extraction chamber 4111 along with the sodium heparin raw material during stirring, and the reaction resin can flow into the extraction chamber 4111 of the top unit shell through the upper through groove 341; the reaction resin can only enter the extraction chamber 4111 of the next layer through the middle through groove 331.

[0042] Specifically, in this example, the flow of the reaction resin between the two extraction units 41 is limited by the middle partition 33, so that the reaction resin can be evenly spread in each extraction chamber 4111, so that the reaction resin has enough expansion space after adsorption, and at the same time, the upper partition 34 is used to interfere with the top unit shell to limit the reaction resin from flowing out of the extraction chamber 4111 along with the sodium heparin raw material during stirring, so that the extraction chamber 4111 can remain relatively sealed, thereby further protecting the reaction resin.

[0043] As an alternative example, see Figures 1 to 9 As shown, in order to facilitate the discharge of the reaction resin, a discharge piece 6 is fixed in the mixing chamber 101 by welding, and a discharge pipe 61 extending out of the mixing chamber 101 is provided at the bottom of the discharge piece 6, and the top of the discharge piece 6 is connected to the middle partition 33 of the bottom support frame 31, and a discharge trough 62 is provided at the top of the discharge piece 6, and the middle through groove 331 is connected to the discharge trough 62 and the discharge pipe 61. Among them, the bottom of the discharge trough 62 is provided with an inclined portion 621 and a discharge portion 622 connected to each other, and the discharge portion 622 is connected to the discharge pipe 61, and the inclined portion 621 can facilitate the discharge of the reaction resin.

[0044] Specifically, in this example, by adding a discharge member 6, the reaction resin can be discharged along the guidance of the discharge trough 62, which facilitates the discharge of the reaction resin, ensures the discharge efficiency of the reaction resin, and avoids the accumulation of the reaction resin in the extraction unit 41.

[0045] As an alternative example, see Figures 1 to 9As shown, in order to facilitate the reaction resin to enter the guide groove 71, a guide member 7 is provided on the top of the mixing chamber 101, and a guide groove 71 is provided in the guide member 7. A feeding pipe 104 connected to the mixing chamber 101 is fixed to the top of the extraction barrel 1 by welding. One end of the guide groove 71 is connected to the feeding pipe 104, and the other end of the guide groove 71 is connected to the upper through groove 341. The upper through groove 341, the middle through groove 331, the discharge groove 62 and the discharge pipe 61 are combined to form a feeding channel 301.

[0046] Specifically, in this example, the reaction resin enters the guide groove 71 through the feeding tube 104, so that the reaction resin can accurately flow into the extraction chamber 4111 of the top unit shell through the upper through groove 341, which facilitates the reaction resin to enter the guide groove 71 and ensures the stability of the reaction resin during feeding.

[0047] As an alternative example, see Figures 1 to 9 As shown, in order to facilitate the discharge of the reaction resin in the extraction chamber 4111 , an extraction through groove 4114 penetrating the unit shell is opened at the bottom of the extraction chamber 4111 , and the extraction through groove 4114 can be connected to the middle through groove 331 .

[0048] Specifically, in this example, when the reaction resin needs to flow, the unit shell is rotated by force until the extraction groove 4114 is connected to the middle groove 331, and the reaction resin flows into the extraction chamber 4111 of the next layer or flows into the discharge trough 62 for discharge through the extraction groove 4114 and the middle groove 331, thereby realizing automatic discharge of the reaction resin, ensuring the relative sealing of the extraction chamber 4111, and facilitating the discharge of the reaction resin in the extraction chamber 4111.

[0049] As an alternative example, see Figures 1 to 9 As shown, the drive assembly 5 includes at least two groups of drive motors 52, and the drive end 51 includes a drive shaft 511 and a drive gear 512. The drive motor 52 is fixedly connected to the unit shell by bolt connection, and the drive shaft 511 is connected to the connecting frame 3 by bearing. The upper end of the drive shaft 511 extends out of the mixing chamber 101 and is fixedly connected to the output shaft of a group of drive motors 52 by a coupling. The drive gear 512 is fixedly connected to the drive shaft 511 by key connection and is arranged in the mixing chamber 101. A plurality of driven teeth 4115 are arranged in a circle on the outer wall of the unit shell with the rotation center line of the unit shell as the center, and the drive gear 512 is meshed with the driven teeth 4115.

[0050] Specifically, in this example, through the operation of the driving motor 52, the output shaft of the driving motor 52 drives the driving shaft 511 to rotate, the driving shaft 511 drives the driving gear 512 to rotate, and the driving gear 512 drives the unit housing to rotate through the driven gear 4115, thereby realizing the connection and closing of the extraction slot 4114 and the middle slot 331 of each extraction unit 41.

[0051] As an alternative example, see Figures 1 to 9 As shown, in order to reduce the use cost of the heparin sodium extraction device, the extraction barrel 1 includes a lower barrel body 11 and an upper barrel body 12 connected to each other, a heat-insulating interlayer 13 is fixed on the outer wall of the lower barrel body 11, a temperature-controlling component 14 is arranged in the heat-insulating interlayer 13, and the temperature-controlling component 14 is in conflict with the upper barrel body 12. The temperature-controlling component 14 can be a heating element, such as a heating wire, a heating ring, etc., for controlling the temperature of the heparin sodium raw material in the extraction barrel 1.

[0052] Specifically, in this example, the temperature of the mixing chamber 101 is controlled by the temperature control component 14, so that the sodium heparin raw material can reach the set temperature, providing equipment support for the sodium heparin extraction process. At the same time, the thermal insulation interlayer 13 can effectively keep warm, reducing the use cost of the sodium heparin extraction device.

[0053] As an alternative example, see Figures 1 to 9 As shown, the stirring and mixing assembly 2 also includes a stirring motor 23 fixed to the outside of the extraction barrel 1 by bolt connection. The upper end of the stirring main shaft 21 extends out of the mixing chamber 101 and is driven and connected to the output shaft of the stirring motor 23 through a coupling.

[0054] Specifically, in this example, the stirring motor 23 drives the stirring shaft 21 to rotate, and the stirring shaft 21 drives the stirring part 22 to rotate, thereby achieving sufficient mixing of the sodium heparin raw material and ensuring the extraction quality of the sodium heparin.

[0055] In general, the present invention realizes part of the process of sodium heparin extraction through the cooperation of the extraction component 4 and the stirring and mixing component 2, thereby ensuring the extraction quality of sodium heparin. At the same time, by adding a plurality of groups of extraction units 41 arranged vertically in the mixing chamber 101, the reaction resin can be evenly arranged in the mixing chamber 101, ensuring that the reaction resin can be fully exchanged with the sodium heparin raw material. In addition, by adding a plurality of groups of extraction chambers 4111, the reaction resin can have enough expansion space after adsorption, thereby avoiding the reaction resin from being squeezed and broken after excessive expansion, so that the reaction resin can be reused, reducing the extraction cost of sodium heparin and further improving the service life of the reaction resin.

[0056] Those skilled in the art should understand that the discussion of any of the above embodiments is merely illustrative and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples. Under the concept of the present invention, the technical features in the above embodiments or different embodiments may be combined, the steps may be implemented in any order, and there are many other variations of the different aspects of the present invention as described above, which are not provided in detail for the sake of simplicity.

[0057] The present invention is intended to cover all such substitutions, modifications and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A heparin sodium extraction device, characterized in that: include: An extraction barrel (1) has a mixing chamber (101) arranged vertically, and an outer wall of the extraction barrel (1) is provided with a liquid inlet pipe (102) and a liquid outlet pipe (103) which are connected to the mixing chamber (101); A stirring and mixing assembly (2) comprises a stirring main shaft (21) which is installed in the mixing chamber (101) in a rotationally connected manner, and a stirring portion (22) is provided on the outer wall of the stirring main shaft (21); A connecting frame (3) is fixed in the mixing chamber (101) and has a feeding channel (301) communicating with the outside; An extraction component (4) comprises at least two groups of extraction units (41) arranged in sequence along a vertical direction, wherein the extraction units (41) are fixedly mounted on a connection frame (3) by means of rotation, the extraction units (41) are in an annular structure, an extraction channel (411) is provided in the extraction unit (41) and vertically penetrates the extraction unit (41), the movement path of the extraction channel (411) passes through a feeding channel (301), and the connection between the two groups of extraction channels (411) and the feeding channel (301) is controlled by the rotation of the extraction unit (41), and the extraction unit (41) has an exchange flow channel (412) penetrating the inner and outer walls of the extraction unit (41), and the exchange flow channel (412) is connected to the extraction channel (411); A driving assembly (5) is fixedly connected to the extraction barrel (1) and has at least two sets of driving ends (51). The driving ends (51) are drivingly connected to corresponding extraction units (41) and are used to drive the extraction units (41) to rotate.

2. The heparin sodium extraction device according to claim 1, characterized in that: The extraction unit (41) comprises a unit shell, wherein the unit shell is provided with a plurality of groups of extraction chambers (4111) in an arc shape with the center line of the unit shell as the center, wherein the extraction chambers (4111) are combined to form an extraction channel (411), wherein the extraction chamber (4111) is provided with a plurality of inner circle through grooves (4112) at one end of the unit shell inner circle, wherein an inner circle partition net (413) is fixed in the inner circle through grooves (4112), wherein the extraction chamber (4111) is provided with a plurality of outer circle through grooves (4113) at one end of the unit shell outer circle, wherein an outer circle partition net (414) is fixed in the outer circle through grooves (4113), wherein one inner circle through groove (4112) and one outer circle through groove (4113) are both connected to the corresponding extraction chamber (4111), and the inner circle partition net (413) and the outer circle partition net (414) are combined to form an exchange flow channel (412).

3. The heparin sodium extraction device according to claim 2, characterized in that: The outer diameter of the unit shell is smaller than the inner wall diameter of the mixing chamber (101); the unit shell separates the mixing chamber (101) into an outer chamber (1011) and an inner chamber (1012); and the stirring portion (22) is disposed in the inner chamber (1012).

4. The heparin sodium extraction device according to claim 3, characterized in that: The connecting frame (3) comprises at least two groups of support frames (31) which are fixedly connected in sequence along the vertical direction and a plurality of support rods (32) used to connect the support frames (31); a middle partition (33) is fixed at the bottom of the support frame (31); a middle through groove (331) penetrating the middle partition (33) is provided on the middle partition (33); an upper partition (34) is fixed at the upper end of the support frame (31); an upper through groove (341) penetrating the upper partition (34) is provided on the top of the upper partition (34).

5. The heparin sodium extraction device according to claim 4, characterized in that: A discharge piece (6) is also fixed in the mixing chamber (101); a discharge pipe (61) extending out of the mixing chamber (101) is arranged at the bottom of the discharge piece (6); the top of the discharge piece (6) is connected to the middle partition (33) of the bottom support frame (31); a discharge trough (62) is provided at the top of the discharge piece (6); and the middle through groove (331) is connected to the discharge trough (62) and the discharge pipe (61).

6. The heparin sodium extraction device according to claim 5, characterized in that: A guide member (7) is provided at the top of the mixing chamber (101), a guide groove (71) is provided in the guide member (7), a feeding pipe (104) connected to the mixing chamber (101) is provided at the top of the extraction barrel (1), one end of the guide groove (71) is connected to the feeding pipe (104), and the other end of the guide groove (71) is connected to the upper through groove (341), and the upper through groove (341), the middle through groove (331), the discharge groove (62) and the discharge pipe (61) are combined to form a feeding channel (301).

7. The heparin sodium extraction device according to claim 6, characterized in that: An extraction through groove (4114) penetrating the unit shell is provided at the bottom of the extraction chamber (4111), and the extraction through groove (4114) can be connected to the middle through groove (331).

8. The heparin sodium extraction device according to claim 7, characterized in that: The driving assembly (5) comprises at least two groups of driving motors (52), the driving end (51) comprises a driving shaft (511) and a driving gear (512), the driving motor (52) is fixedly connected to the extraction barrel (1), the driving shaft (511) is connected to the connecting frame (3) by means of rotation, the upper end of the driving shaft (511) extends out of the mixing chamber (101) and is fixedly connected to an output shaft of a group of the driving motors (52), the driving gear (512) is fixedly connected to the driving shaft (511) and is arranged in the mixing chamber (101), and a plurality of driven teeth (4115) are arranged in a circle on the outer wall of the unit shell with the rotation center line of the unit shell as the center, and the driving gear (512) is meshed with the driven teeth (4115).

9. The heparin sodium extraction device according to claim 1, characterized in that: The extraction barrel (1) comprises a lower barrel body (11) and an upper barrel body (12) which are connected to each other, a heat-insulating interlayer (13) is fixed on the outer wall of the lower barrel body (11), a temperature-controlling component (14) is arranged in the heat-insulating interlayer (13), and the temperature-controlling component (14) is in conflict with the upper barrel body (12).

10. The heparin sodium extraction device according to claim 1, characterized in that: The stirring and mixing assembly (2) further comprises a stirring motor (23) fixed outside the extraction barrel (1); the upper end of the stirring main shaft (21) extends out of the mixing chamber (101) and is drivingly connected to the output shaft of the stirring motor (23).

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