Freeze-drying preparation device and process for transfer factor capsules

Abstract

The invention relates to the technical field of medicine, and discloses a freeze-drying preparation device and process for transfer factor capsules, the freeze-drying preparation device for the transfer factor capsules comprises a crushing kettle, a mounting plate is fixedly connected to the side wall of the crushing kettle, and a lifting assembly is arranged on the top end face of the mounting plate. The freeze-drying preparation device for the transfer factor capsules comprises a lifting motor, the lifting motor is fixedly connected to the bottom end face of a mounting plate, the output end of the lifting motor is fixedly connected with a threaded rod, the side wall of the threaded rod is in threaded connection with a cover body, the bottom end face of the cover body is provided with a downward pressing assembly, and the downward pressing plate intermittently presses downwards. When the blade rotates, the thrown tissue is flapped downwards again, so that the tissue falls onto the blade again under the action of inertia and then is crushed by the blade, and the mounting sleeve and the blade are driven to move longitudinally along the rotating shaft through the longitudinal movement of the lower pressing plate and the transmission of the connecting sleeve, so that the crushing coverage range of the blade is enlarged.

Description

Technical Field

[0001] The invention relates to the technical field of medicine, in particular to a freeze-drying preparation device and process for transfer factor capsules. Background Art

[0002] Transfer factor is a mixture of biologically active polypeptides and nucleotides with a molecular weight of less than 10,000 that can transmit delayed hypersensitivity reactions. Its activity is not destroyed by trypsin or ribonuclease, and it is heat-resistant and has no species boundaries. It is currently mainly used to treat viral infections and autoimmune diseases. It can bidirectionally regulate the body's immune function, and has a bidirectional immunomodulatory effect on the increase and decrease of cellular and humoral immune functions. It also promotes the proliferation of T lymphocytes and has a regulatory effect on bone marrow hematopoietic immune function. Up to now, the official products of transfer factor on the market include injections, oral solutions and transfer factor capsules.

[0003] The process of transfer factor capsules usually includes pretreatment of fresh tissue, that is, crushing and then homogenizing, repeated freezing and thawing several times, and then centrifuging using a high-speed refrigerated centrifuge, taking the centrifuge, dialyzing the centrifuge, taking the dialysate, ultrafiltering the dialysate, and taking the ultrafiltrate with a molecular weight of 6000-10000. Ultrafiltrate with different molecular weights is used to prepare transfer factors of different dosage forms.

[0004] However, in the actual crushing process of the above-mentioned fresh tissue, due to the certain toughness and structural complexity of the tissue itself, the blade is often unable to completely penetrate or penetrate the tissue during rotation, resulting in the tissue being thrown to the inner wall of the crushing container by the blade. In this way, the crushing effect of the tissue is greatly reduced, and uniform and detailed cutting cannot be achieved, so that the tissue cannot be completely lysed, affecting the subsequent extraction and separation effects; in view of this, we proposed a freeze-drying preparation device and process for transfer factor capsules. Summary of the invention

[0005] The purpose of the present invention is to provide a freeze-drying preparation device and process for transfer factor capsules to solve the problems raised in the above background technology.

[0006] To achieve the above object, the present invention provides the following technical solution: a freeze-drying preparation device for transfer factor capsules, comprising a crushing kettle, a side wall of which is fixedly connected to a mounting plate, a top end surface of which is provided with a lifting assembly, and the lifting assembly comprises:

[0007] A lifting motor, wherein the lifting motor is fixedly connected to the bottom end surface of the mounting plate, a threaded rod is fixedly connected to the output end of the lifting motor, a cover body is threadedly connected to the side wall of the threaded rod, and a pressing assembly is provided on the bottom end surface of the cover body;

[0008] The pressing assembly comprises:

[0009] A rotating motor, wherein the rotating motor is fixedly connected to the top end surface of the cover body, an output end of the rotating motor is fixedly connected to a rotating shaft, and a side wall of the rotating shaft is provided with a crushing assembly;

[0010] A shell, the shell is fixedly connected to the bottom end surface of the cover body, the inner top of the shell is rotatably connected to a reciprocating screw rod, and the side wall of the reciprocating screw rod is threadedly connected to a connecting piece;

[0011] A lower pressing plate, the lower pressing plate being fixedly connected to the bottom end surface of the connecting piece;

[0012] The crushing assembly comprises:

[0013] A mounting sleeve, the top of which is sleeved with a connecting sleeve, the connecting sleeve is fixedly connected to the bottom end surface of the lower pressing plate, the mounting sleeve is sleeved with the rotating shaft, and a blade is fixedly connected to the side wall of the mounting sleeve;

[0014] A fan-shaped plate, wherein the side wall of the fan-shaped plate is fixedly connected with a rotating shaft.

[0015] Preferably, the connecting piece is sleeved with the inner bottom surface of the shell, and the diameter of the shell is equal to the inner diameter of the crushing kettle.

[0016] Preferably, the side wall of the reciprocating screw is fixedly connected with a pulley, the side wall of the rotating shaft is fixedly connected with a pulley, and the side wall of the pulley is transmission-connected with a belt, which drives the rotating shaft to rotate.

[0017] Preferably, the top end face of the mounting plate is fixedly connected with a vertical rod, the vertical rod is socketed with the side wall of the cover body, the length of the threaded rod is equal to the length of the crushing assembly, and the vertical rod limits the mounting plate so that when the lifting motor drives the threaded rod to rotate, the cover body can move longitudinally, and the cover body moves upward to open the crushing kettle, so that the tissue can be placed or removed, and the device can be flushed at the same time.

[0018] Preferably, a connecting rod is fixedly connected to the side wall of the rotating shaft, an end of the connecting rod away from the rotating shaft is fixedly connected to a mounting ring, a top end surface of the mounting ring is fixedly connected to an arc plate, and the arc plate is movably connected to the inner wall of the crushing kettle.

[0019] Preferably, the number of the arc plates is arranged in several groups, and the arc plates in several groups are arranged at equal intervals on the side wall of the mounting ring. The tops of the arc plates in several groups are fixedly connected by fixedly connected connecting rings. The arc plates drive the tissue below to flip upward, and at the same time, the arc plates scrape the inner wall of the crushing kettle to prevent the tissue from adhering to the inner wall of the crushing kettle for a long time, thereby improving the crushing effect of the tissue.

[0020] Preferably, a guide ring is fixedly connected to the bottom end surface of the lower pressure plate, and the outer wall of the guide ring is movably connected to the inner wall of the crushing kettle.

[0021] Preferably, the inner wall of the guide ring is arranged in an arc shape, and the inner wall of the guide ring is provided with a large diameter end and a small diameter end, the small diameter end is arranged on a side close to the lower pressure plate, and the large diameter end is arranged on a side away from the lower pressure plate.

[0022] Preferably, the rotating shaft includes a cylinder one, a hexagonal prism and a cylinder two, the cylinder one is fixedly connected to the output end of the rotating motor, the hexagonal prism is fixedly connected to the bottom end of the cylinder one, the cylinder two is fixedly connected to the bottom end of the hexagonal prism, the cylinder one is socketed with the shell, the cylinder one is socketed with the lower pressure plate, the hexagonal prism is socketed with the mounting sleeve, the side wall of the cylinder two is fixedly connected with a fan-shaped plate, the fan-shaped plate is movably connected to the inner bottom of the crushing kettle, the side wall of the cylinder two is fixedly connected with a connecting rod, the rotation of the rotating shaft can drive the mounting sleeve and the blade to rotate, the blade can further crush the tissue, the rotation of the rotating shaft drives the fan-shaped plate to rotate, stirs the tissue sunk to the bottom, makes the tissue contact with the blade again, and is crushed by the blade.

[0023] A freeze-drying preparation process of transfer factor capsules, the preparation process comprising the following steps:

[0024] S1. Disintegrate fresh tissue at 10-12℃;

[0025] S2, freeze-thaw the tissue three times to further disrupt the cells;

[0026] S3, centrifuging the tissue using a high-speed refrigerated centrifuge to obtain a centrifuge;

[0027] S4, filtering the centrifuge liquid by a filter press;

[0028] S5, performing dialysis ultrafiltration on the centrifuge liquid to obtain a substance with a molecular weight in the range of 6000-10000;

[0029] S6. Using nanofiltration technology to concentrate the transfer factor ultrafiltrate to obtain a high-concentration raw material solution;

[0030] S7, using freeze drying to concentrate the transfer factor stock solution into a powder;

[0031] S8, adding excipients and auxiliary materials into the powder to prepare microparticles;

[0032] S9. Put into capsules to make transfer factor capsules.

[0033] Compared with the prior art, the present invention provides a freeze-drying preparation device and process for transfer factor capsules, which has the following beneficial effects:

[0034] 1. The freeze-drying preparation device and process of the transfer factor capsules are provided with a lifting component, a pressing component and a crushing component. The lower pressing plate intermittently presses down to push the tissue that has been thrown up downward again, so that this part of the tissue falls back onto the blade due to inertia and is then crushed by the blade. The longitudinal movement of the lower pressing plate drives the installation sleeve and the blade to move longitudinally along the rotating shaft through the transmission of the connecting sleeve, thereby increasing the coverage of the blade crushing. The fan-shaped plate is movably connected to the inner bottom of the crushing kettle to stir up the tissue that has sunk to the bottom, so that the tissue contacts the blade again and is then crushed by the blade, thereby improving the crushing effect of the tissue and thereby improving the extraction effect of the tissue fluid.

[0035] 2. The freeze-drying preparation device and process of the transfer factor capsule drives the tissue below to flip upward through the arc plate, and at the same time the arc plate scrapes the inner wall of the crushing kettle to prevent the tissue from adhering to the inner wall of the crushing kettle for a long time, thereby improving the crushing effect of the tissue.

[0036] 3. The freeze-drying preparation device and process of the transfer factor capsules are characterized by the provision of a guide ring. During the downward pressing process of the lower pressure plate, the guide ring scrapes the inner wall of the crushing kettle, gathers the tissue attached to the inner wall of the crushing kettle to the middle, and then can be thrown back onto the blade as the lower pressure plate presses downward, thereby improving the crushing effect of the tissue. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 It is a schematic diagram of the main structure of the present invention;

[0038] Figure 2 It is a schematic diagram of the cross-sectional structure of the main body of the present invention;

[0039] Figure 3 It is a schematic diagram of the cross-sectional structure of the shell of the present invention;

[0040] Figure 4 For the present invention Figure 3 Schematic diagram of the structure of the middle A area;

[0041] Figure 5 This is a schematic diagram of the structure of the lower pressing plate of the present invention;

[0042] Figure 6 This is a schematic diagram of the structure of the crushing assembly of the present invention;

[0043] Figure 7 This is a schematic diagram of the cross-sectional structure of the lower pressing plate of the present invention;

[0044] Figure 8 It is a schematic diagram of the arc plate structure of the present invention.

[0045] In the figure: 1. Crushing kettle; 2. Mounting plate; 3. Lifting assembly; 301. Lifting motor; 302. Threaded rod; 304. Vertical rod; 305. Cover; 4. Pressing assembly; 401. Rotating motor; 402. Rotating shaft; 403. Shell; 404. Reciprocating screw rod; 405. Belt; 406. Connecting piece; 407. Pressing plate; 5. Crushing assembly; 501. Connecting sleeve; 502. Mounting sleeve; 503. Blade; 504. Fan plate; 6. Connecting rod; 7. Mounting ring; 8. Arc plate; 9. Guide ring. DETAILED DESCRIPTION

[0046] like Figure 1-Figure 8 As shown, the present invention provides a technical solution: a freeze-drying preparation device for transfer factor capsules, comprising a crushing kettle 1, a side wall of the crushing kettle 1 is fixedly connected with a mounting plate 2, a top end surface of the mounting plate 2 is provided with a lifting assembly 3, and the lifting assembly 3 includes a lifting motor 301, a threaded rod 302, a vertical rod 304, and a cover body 305.

[0047] In one embodiment of the present invention, a lifting motor 301 is fixedly connected to the bottom end surface of the mounting plate 2, a threaded rod 302 is fixedly connected to the output end of the lifting motor 301, a cover body 305 is threadedly connected to the side wall of the threaded rod 302, a vertical rod 304 is fixedly connected to the top end surface of the mounting plate 2, the vertical rod 304 is socketed with the side wall of the cover body 305, the length of the threaded rod 302 is equal to the length of the crushing assembly 5, the vertical rod 304 limits the mounting plate 2, so that when the lifting motor 301 drives the threaded rod 302 to rotate, the cover body 305 can move longitudinally, and the cover body 305 moves upward to open the crushing kettle 1, so that the tissue can be placed or removed, and the device can be flushed at the same time, and a downward pressing assembly 4 is provided on the bottom end surface of the cover body 305.

[0048] The pressing assembly 4 includes a rotating motor 401 , a rotating shaft 402 , a housing 403 , a reciprocating screw rod 404 , a belt 405 , a connecting piece 406 , and a pressing plate 407 .

[0049] The rotating motor 401 is fixedly connected to the top end surface of the cover body 305 , and the output end of the rotating motor 401 is fixedly connected to the rotating shaft 402 , and the side wall of the rotating shaft 402 is provided with a crushing assembly 5 .

[0050] The shell 403 is fixedly connected to the bottom end surface of the cover body 305, the inner top of the shell 403 is rotatably connected to a reciprocating screw rod 404, the side wall of the reciprocating screw rod 404 is fixedly connected to a pulley, the side wall of the rotating shaft 402 is fixedly connected to a pulley, the side wall of the pulley is transmission-connected with a belt 405, the rotating shaft 402 is driven, the side wall of the reciprocating screw rod 404 is threadedly connected to a connecting piece 406, the connecting piece 406 is socketed with the inner bottom surface of the shell 403, the diameter of the shell 403 is equal to the inner diameter of the crushing kettle 1, and the lower pressure plate 407 is fixedly connected to the bottom end surface of the connecting piece 406.

[0051] The crushing assembly 5 includes a connecting sleeve 501 , a mounting sleeve 502 , a blade 503 , and a sector plate 504 .

[0052] The top of the installation sleeve 502 is sleeved with a connecting sleeve 501 , and the connecting sleeve 501 is fixedly connected to the bottom end surface of the lower pressing plate 407 . The installation sleeve 502 is sleeved with the rotating shaft 402 , and the side wall of the installation sleeve 502 is fixedly connected with a blade 503 .

[0053] Specifically, the freeze-drying preparation process of transfer factor capsules includes the following steps:

[0054] S1. Disintegrate fresh tissue at 10-12℃;

[0055] S2, freeze-thaw the tissue three times to further disrupt the cells;

[0056] S3, centrifuging the tissue using a high-speed refrigerated centrifuge to obtain a centrifuge;

[0057] S4, filtering the centrifuge liquid by a filter press;

[0058] S5, performing dialysis ultrafiltration on the centrifuge liquid to obtain a substance with a molecular weight in the range of 6000-10000;

[0059] S6. Using nanofiltration technology to concentrate the transfer factor ultrafiltrate to obtain a high-concentration raw material solution;

[0060] S7, using freeze drying to concentrate the transfer factor stock solution into a powder;

[0061] S8, adding excipients and auxiliary materials into the powder to prepare microparticles;

[0062] S9. Put into capsules to make transfer factor capsules.

[0063] The side wall of the fan-shaped plate 504 is fixedly connected with the rotating shaft 402, and the rotating shaft 402 includes a cylinder 1, a hexagonal prism and a cylinder 2. The cylinder 1 is fixedly connected to the output end of the rotating motor 401, the hexagonal prism is fixedly connected to the bottom end of the cylinder 1, and the cylinder 2 is fixedly connected to the bottom end of the hexagonal prism. The cylinder 1 is socketed with the shell 403, the cylinder 1 is socketed with the lower pressure plate 407, and the hexagonal prism is socketed with the mounting sleeve 502. The side wall of the cylinder 2 is fixedly connected with the fan-shaped plate 504, and the fan-shaped plate 504 is movably connected to the inner bottom of the crushing kettle 1. The side wall of the cylinder 2 is fixedly connected with the connecting rod 6. The rotation of the rotating shaft 402 can drive the mounting sleeve 502 and the blade 503 to rotate, and the blade 503 can further crush the tissue. The rotation of the rotating shaft 402 drives the fan-shaped plate 504 to rotate, stirs the tissue sunk to the bottom, makes the tissue contact with the blade 503 again, and is then crushed by the blade 503.

[0064] A connecting rod 6 is fixedly connected to the side wall of the rotating shaft 402, and a mounting ring 7 is fixedly connected to one end of the connecting rod 6 away from the rotating shaft 402. An arc plate 8 is fixedly connected to the top end face of the mounting ring 7. The arc plate 8 is movably connected to the inner wall of the crushing kettle 1. There are several groups of arc plates 8. Several groups of arc plates 8 are equidistantly arranged on the side wall of the mounting ring 7. The tops of several groups of arc plates 8 are fixedly connected by fixedly connected connecting rings. The arc plate 8 drives the tissue below to flip upward. At the same time, the arc plate 8 scrapes the inner wall of the crushing kettle 1 to prevent the tissue from adhering to the inner wall of the crushing kettle 1 for a long time, thereby improving the crushing effect of the tissue.

[0065] The bottom end face of the lower pressure plate 407 is fixedly connected with a guide ring 9, the outer wall of the guide ring 9 is movably connected with the inner wall of the crushing kettle 1, the inner wall of the guide ring 9 is arranged in an arc shape, and the inner wall of the guide ring 9 is provided with a large diameter end and a small diameter end, the small diameter end is arranged on the side close to the lower pressure plate 407, and the large diameter end is arranged on the side away from the lower pressure plate 407.

[0066] When the lifting motor 301 drives the threaded rod 302 to rotate, the cover body 305 is able to move longitudinally, and the cover body 305 moves upward to open the crushing kettle 1, so that the tissue can be placed or taken out, and the device can be rinsed by lifting the cover body 305.

[0067] The rotating motor 401 is started to drive the rotating shaft 402 to rotate, and the rotating shaft 402 drives the mounting sleeve 502 and the blade 503 to rotate. The blade 503 breaks the tissue. During the cutting process, cells and tissues will be compressed, stretched or torn by mechanical force, causing cell fluid to flow out.

[0068] The rotation of the rotating shaft 402 drives the reciprocating screw rod 404 to rotate through the transmission of the belt 405, and the rotation of the reciprocating screw rod 404 drives the connecting piece 406 and the lower pressure plate 407 to reciprocate longitudinally. The lower pressure plate 407 intermittently presses down to push the tissue that has been thrown up downward again, so that this part of the tissue falls back onto the blade 503 due to inertia and is then crushed by the blade 503. The longitudinal movement of the lower pressure plate 407 drives the installation sleeve 502 and the blade 503 to move longitudinally along the rotating shaft 402 through the transmission of the connecting sleeve 501, thereby increasing the crushing coverage of the blade 503.

[0069] The rotation of the rotating shaft 402 drives the fan-shaped plate 504 to rotate. The fan-shaped plate 504 is movably connected to the inner bottom of the crushing kettle 1, stirring the tissue sunk to the bottom, so that the tissue contacts the blade 503 again and is crushed by the blade 503, thereby improving the crushing effect of the tissue and further improving the extraction effect of the tissue fluid.

[0070] In order to promote the full crushing of the tissue, the side wall of the rotating shaft 402 is fixedly connected with a connecting rod 6, and the end of the connecting rod 6 away from the rotating shaft 402 is fixedly connected with a mounting ring 7, and the top end face of the mounting ring 7 is fixedly connected with an arc plate 8, and the arc plate 8 is movably connected to the inner wall of the crushing kettle 1. The number of arc plates 8 is arranged in several groups, and several groups of arc plates 8 are arranged on the side wall of the mounting ring 7 at equal intervals. The tops of several groups of arc plates 8 are fixedly connected by fixedly connected connecting rings. The arc plate 8 drives the tissue below to flip upward, and at the same time, the arc plate 8 scrapes the inner wall of the crushing kettle 1 to prevent the tissue from adhering to the inner wall of the crushing kettle 1 for a long time, thereby improving the crushing effect of the tissue.

[0071] In addition, in order to further improve the crushing effect on the tissue, a guide ring 9 is fixedly connected to the bottom end face of the lower pressure plate 407, and the outer wall of the guide ring 9 is movably connected to the inner wall of the crushing kettle 1. The inner wall of the guide ring 9 is arranged in an arc shape, and the inner wall of the guide ring 9 is provided with a large diameter end and a small diameter end. The small diameter end is arranged on the side close to the lower pressure plate 407, and the large diameter end is arranged on the side away from the lower pressure plate 407. In the process of pressing down the lower pressure plate 407, the guide ring 9 scrapes the inner wall of the crushing kettle 1 and gathers the tissue attached to the inner wall of the crushing kettle 1 to the middle, and then it can be thrown onto the blade 503 again as the lower pressure plate 407 presses down, thereby improving the crushing effect on the tissue.

[0072] In the present invention, when in use, the lifting motor 301 drives the cover body 305 to move longitudinally to open the crushing kettle 1, place or take out the tissue, the rotating motor 401 drives the blade 503 to rotate, and the blade 503 moves longitudinally along the rotating shaft 402 to crush the tissue, the lower pressure plate 407 intermittently presses down to push the thrown tissue downward again, and then it is crushed by the blade 503, the arc plate 8 drives the tissue below to flip upward, and at the same time the arc plate 8 scrapes the inner wall of the crushing kettle 1 to prevent the tissue from adhering to the inner wall of the crushing kettle 1 for a long time.

[0073] The above generally describes the present invention in detail, but it is obvious to a person skilled in the art that some modifications or improvements can be made to the present invention. Therefore, modifications or improvements that do not depart from the spirit of the present invention are within the scope of protection of the present invention.

Claims

1. A freeze-drying preparation device for transfer factor capsules, comprising a crushing kettle (1), the side wall of which is fixedly connected with a mounting plate (2), characterized in that: The top end surface of the mounting plate (2) is provided with a lifting assembly (3), and the lifting assembly (3) comprises: A lifting motor (301), the lifting motor (301) is fixedly connected to the bottom end surface of the mounting plate (2), the output end of the lifting motor (301) is fixedly connected to a threaded rod (302), the side wall of the threaded rod (302) is threadedly connected to a cover body (305), and the bottom end surface of the cover body (305) is provided with a pressing assembly (4); The pressing component (4) comprises: A rotating motor (401), wherein the rotating motor (401) is fixedly connected to the top end surface of the cover body (305), an output end of the rotating motor (401) is fixedly connected to a rotating shaft (402), and a crushing assembly (5) is provided on a side wall of the rotating shaft (402); A shell (403), the shell (403) is fixedly connected to the bottom end surface of the cover body (305), the inner top of the shell (403) is rotatably connected to a reciprocating screw rod (404), and the side wall of the reciprocating screw rod (404) is threadedly connected to a connecting piece (406); A lower pressing plate (407), wherein the lower pressing plate (407) is fixedly connected to the bottom end surface of the connecting member (406); The crushing assembly (5) comprises: A mounting sleeve (502), the top of which is sleeved with a connecting sleeve (501), the connecting sleeve (501) being fixedly connected to the bottom end surface of the lower pressing plate (407), the mounting sleeve (502) being sleeved with the rotating shaft (402), and the side wall of the mounting sleeve (502) being fixedly connected with a blade (503); A fan-shaped plate (504), wherein a side wall of the fan-shaped plate (504) is fixedly connected to a rotating shaft (402).

2. The freeze-drying preparation device for transfer factor capsules according to claim 1, characterized in that: The connecting piece (406) is sleeved with the inner bottom surface of the shell (403), and the diameter of the shell (403) is equal to the inner diameter of the crushing kettle (1).

3. The freeze-drying preparation device for transfer factor capsules according to claim 1, characterized in that: The side wall of the reciprocating screw rod (404) is fixedly connected to a pulley, the side wall of the rotating shaft (402) is fixedly connected to a pulley, and the side wall of the pulley is transmission-connected to a belt (405).

4. The freeze-drying preparation device for transfer factor capsules according to claim 1, characterized in that: A vertical rod (304) is fixedly connected to the top end surface of the mounting plate (2), and the vertical rod (304) is sleeved with the side wall of the cover body (305). The length of the threaded rod (302) is equal to the length of the crushing assembly (5).

5. The freeze-drying preparation device for transfer factor capsules according to claim 1, characterized in that: The side wall of the rotating shaft (402) is fixedly connected to a connecting rod (6), one end of the connecting rod (6) away from the rotating shaft (402) is fixedly connected to a mounting ring (7), the top end surface of the mounting ring (7) is fixedly connected to an arc plate (8), and the arc plate (8) is movably connected to the inner wall of the crushing kettle (1).

6. The freeze-drying preparation device for transfer factor capsules according to claim 5, characterized in that: The number of the arc plates (8) is arranged in a plurality of groups, and the arc plates (8) in the plurality of groups are arranged at equal intervals on the side wall of the mounting ring (7), and the tops of the arc plates (8) in the plurality of groups are fixedly connected via a fixedly connected connecting ring.

7. The freeze-drying preparation device for transfer factor capsules according to claim 1, characterized in that: The bottom end surface of the lower pressure plate (407) is fixedly connected to a guide ring (9), and the outer wall of the guide ring (9) is movably connected to the inner wall of the crushing kettle (1).

8. The freeze-drying preparation device for transfer factor capsules according to claim 7, characterized in that: The inner wall of the guide ring (9) is arranged in an arc shape, and the inner wall of the guide ring (9) is provided with a large diameter end and a small diameter end, the small diameter end is arranged on a side close to the lower pressure plate (407), and the large diameter end is arranged on a side away from the lower pressure plate (407).

9. The freeze-drying preparation device for transfer factor capsules according to claim 5, characterized in that: The rotating shaft (402) includes a cylinder 1, a hexagonal prism and a cylinder 2, wherein the cylinder 1 is fixedly connected to the output end of the rotating motor (401), the hexagonal prism is fixedly connected to the bottom end of the cylinder 1, and the cylinder 2 is fixedly connected to the bottom end of the hexagonal prism. The cylinder 1 is sleeved with the shell (403), the cylinder 1 is sleeved with the lower pressure plate (407), the hexagonal prism is sleeved with the mounting sleeve (502), the side wall of the cylinder 2 is fixedly connected with a fan-shaped plate (504), the fan-shaped plate (504) is movably connected to the inner bottom of the crushing kettle (1), and the side wall of the cylinder 2 is fixedly connected with a connecting rod (6).

10. A freeze-drying preparation process of transfer factor capsules, based on the freeze-drying preparation device of transfer factor capsules according to claims 1-9, characterized in that: The preparation process comprises the following steps: S1. Disintegrate fresh tissue at 10-12℃; S2, freeze-thaw the tissue three times to further disrupt the cells; S3, centrifuging the tissue using a high-speed refrigerated centrifuge to obtain a centrifuge; S4, filtering the centrifuge liquid by a filter press; S5, performing dialysis ultrafiltration on the centrifuge liquid to obtain a substance with a molecular weight in the range of 6000-10000; S6. Using nanofiltration technology to concentrate the transfer factor ultrafiltrate to obtain a high-concentration raw material solution; S7, using freeze drying to concentrate the transfer factor stock solution into a powder; S8, adding excipients and auxiliary materials into the powder to prepare microparticles; S9. Put into capsules to make transfer factor capsules.

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