A radionuclide experimental device and method for laboratory use

Abstract

The present invention relates to the field of laboratory technology and is a radionuclide experimental device and method for laboratory use. The device comprises an experimental hot chamber, which is equipped with a central integrated electronic controller for managing the operation of the subpackaging experimental hot chamber. In addition, the experimental hot chamber is also equipped with a vertical laminar flow ventilation system with a HEPA full high efficiency filter to ensure air purification. In the experimental hot chamber, a fully automatic subpackaging system is installed to meet all the needs of radioactive drug subpackaging. In response to the actual subpackaging needs of radioactive drugs, an automated system that meets the CGMP standards for the subpackaging of radioactive isotope drugs has been developed. Through the operation of an external central workstation, the system can automatically subpack high-activity nuclide drugs into syringes and vials, and automatically dilute physiological saline to meet the specific activity required by different patients.

Description

Technical Field

[0001] The invention belongs to the technical field of laboratories, and in particular relates to a radionuclide experimental device and a method for laboratories. Background Art

[0002] Laboratory (Lab) is a place where experiments are conducted. The laboratory is the cradle of science, the base of scientific research, and the place that scientific and technological workers yearn for and follow. Excellent laboratories often represent the highest level of cutting-edge basic research in the world, are very likely to produce Nobel Prize winners and epoch-making scientific and technological innovations, and are important places for high-level academic exchanges.

[0003] Radioactive nuclides, also called unstable nuclides, are relative to stable nuclides. They refer to unstable atomic nuclei that can spontaneously emit radiation (such as alpha rays, beta rays, etc.) and form stable nuclides through decay. Interventional therapy with radionuclides is an important part of nuclear medicine. It uses puncture, intubation, implantation and other means to introduce high-activity radioactive nuclide preparations into the lesion site through blood vessels, body cavities, cysts, tissue interstitium or lymph collecting areas with appropriate carriers, thereby directly irradiating the diseased tissues and cells. Radioactive nuclides need to be diluted with physiological saline before use so that they can meet the injection standards before they can be used. After the radioactive nuclides are diluted with saline, they need to be filled and the diluted radioactive nuclides are packaged into preparations with different doses according to different usage requirements.

[0004] In the process of packaging radionuclides, the existing device cannot continuously fill several containers. From time to time, the device needs to be shut down to wait for the next input data from the staff so that the appropriate dose can be packaged, which reduces the packaging efficiency of the device. At the same time, since the device is constantly turned on and off, the energy consumption of the device is further increased during use, which makes the device have strong limitations during use. Summary of the invention

[0005] In view of the above situation, in order to overcome the defects of the prior art, the present invention provides a laboratory radionuclide experimental device and method thereof, which effectively solves the problems in the above background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a radioactive nuclide experimental device for laboratory use, comprising an experimental hot chamber; a refilling anti-stop mechanism is arranged on the experimental hot chamber, and the refilling anti-stop mechanism is used to continuously dispense the diluted radioactive nuclides to make medicines; the refilling anti-stop mechanism comprises a rotating motor arranged on the bottom surface of the experimental hot chamber by bolts, a rotating disc is connected to the output end of the rotating motor, a plurality of rotating base plates are installed on the outer wall of the rotating disc, a container is penetrated on the top of the rotating base plate, and the container and the rotating base plate are slidably matched; an L-shaped base plate corresponding to the number and position of the rotating base plates is arranged at the bottom of the rotating disc, and a distance control and splash-stop unit is arranged on the L-shaped base plate, and the distance control and splash-stop unit is used to adjust the height of the container when being dispensed; a multi-axis displacer is connected to the inner wall of the experimental hot chamber by bolts, a liquid storage tank is installed on the top of the multi-axis displacer, and a syringe is installed on the slidable part of the bottom of the multi-axis displacer, and the output end of the syringe faces the inner bottom surface of the experimental hot chamber; a delivery pipe is installed on the liquid storage tank, and the delivery pipe is connected to the syringe.

[0007] Preferably, the distance control and splash-stop unit includes a positioning slide column which is arranged through the top of the L-shaped substrate, and the positioning slide column is slidably matched with the L-shaped substrate; a U-shaped square seat is installed at one end of the positioning slide column close to the inner bottom surface of the experimental hot chamber, and a resistance circular wheel is rotatably connected to the U-shaped square seat, and several resistance circular wheels are in contact with the inner bottom surface of the experimental hot chamber; a retaining bevel block is also installed on the inner bottom surface of the experimental hot chamber, and the retaining bevel block is designed as a circular ring and is located directly below the output end of the syringe, and the retaining bevel block is coaxial with the center of the rotating disc; both sides of the retaining bevel block are designed as inclined surfaces, and the inclined surfaces are located on the rotation path of the resistance circular wheel.

[0008] Preferably, a protective circular box is installed at one end of the positioning slide column away from the bottom surface of the experimental hot chamber, and the top of the protective circular box is designed to be open and the opening faces the top surface of the experimental hot chamber; a partial area of ​​the container is located in the protective circular box; a positioning spring is sleeved on the positioning slide column, one end of the positioning spring is fixedly connected to the bottom of the protective circular box, and the other end is fixedly connected to the L-shaped base plate, and the L-shaped base plate is located between the protective circular box and the U-shaped square seat.

[0009] Preferably, a rotating convex ring is installed at the bottom of the rotating disc, and a plurality of rotating blocks are slidably connected to the rotating convex ring, and the plurality of rotating blocks are fixedly arranged on the inner bottom surface of the experimental hot chamber; the rotating convex ring is nested in the rotating block, and the two are slidably matched; a partial area of ​​the container is located in the rotating base plate; the top of the container is an opening, facing the inner top surface of the experimental hot chamber and located below the syringe.

[0010] Preferably, a weight-measured force-reducing component is also provided on the protective circular box; the weight-measured force-reducing component includes a circular buffer ring arranged in the protective circular box, and a circular plate is installed at the bottom of the circular buffer ring; the container is located in the circular buffer ring, and the inner diameter of the circular buffer ring is the same as the outer diameter of the container; the side of the circular plate away from the positioning slide column is in contact with the bottom of the container; and a guide cylinder is also installed on the side of the circular plate close to the positioning slide column.

[0011] Preferably, a guide circular groove with the same diameter as the guide cylinder is provided in the positioning slide column, and one side of the guide circular groove extends to the top of the positioning slide column; a partial area of ​​the guide cylinder is located in the guide circular groove; a pressure sensor is provided on the inner bottom surface of the protective circular box; a guide spring is sleeved on the guide cylinder, one end of the guide spring is connected to the bottom of the circular plate, and the other end is connected to the pressure sensor; the circular buffer ring is slidably matched with the protective circular box.

[0012] Preferably, the U-shaped square seat is also provided with a dynamic straightening assembly; the dynamic straightening assembly includes an L-shaped rack arranged on the side of the U-shaped square seat, the L-shaped rack is meshedly connected with a rotating gear, a rotating shaft is installed on the rotating gear, two rotating base plates are symmetrically installed on the rotating shaft, and the rotating base plate is arranged on the rotating base plate; rotating bevel gears are installed at both ends of the rotating shaft, the rotating bevel gear is meshedly connected with a driven bevel gear, a driven bevel gear is installed on the driven shaft, a driven base plate is installed on the end of the driven shaft away from the driven bevel gear, and the driven base plate is arranged on the rotating base plate; a displacement gear is also installed on the driven shaft, the displacement gear is meshedly connected with a displacement rack, two displacement square plates are symmetrically installed on the displacement rack, and the opposite surfaces of the two displacement square plates are commonly connected with a displacement cylinder.

[0013] Preferably, a displacement base plate is slidably connected to the displacement cylinder, and the displacement base plate is arranged on the driven base plate; a displacement spring is sleeved on the displacement cylinder, one end of the displacement spring is connected to the displacement square plate, and the other end is connected to the displacement base plate; a bent square rod is installed on each of the two displacement racks, and the end points of the two bent square rods are facing the container and a displacement cross plate is also installed, and two limit sliding columns are symmetrically slidably arranged on the displacement cross plate, and the ends of the two limit sliding columns close to the container are jointly connected to a limit arc block, and an energy absorption pad is provided on the inner side wall of the limit arc block, and the outer side wall of the container is located on the moving path of the energy absorption pad; a limit spring is sleeved on the limit sliding column, one end of the limit spring is fixedly connected to the limit arc block, and the other end is fixedly connected to the displacement cross plate.

[0014] Preferably, the refilling anti-stop mechanism also includes a U-shaped pipe, one end of the U-shaped pipe is connected to the side of the top of the syringe, and the other end is connected to the side of the bottom of the syringe; a first valve is installed on the input end and output end of the U-shaped pipe; a second valve is also provided in the syringe, and the second valve is located between the two first valves; a third valve is installed on the output end of the syringe.

[0015] The present invention also provides an experimental method of a radionuclide experimental device for laboratory use, comprising the following steps: S1. After the radioactive nuclide is diluted in the storage tank, it enters the syringe through the delivery tube and is filled into the container; S2, start the rotating motor so that its output end drives the rotating disc to rotate; S3, drives the rotating disc and a plurality of containers to rotate, so as to continuously pack the plurality of containers.

[0016] Compared with the prior art, the present invention has the following beneficial effects: (1) Starting the rotating motor, so that its output end drives the rotating disk to rotate, and then drives the several containers on the rotating disk to rotate, so that the filled container rotates to another place and no longer aligns with the syringe, so that the next container to be filled is rotated to the bottom of the syringe for further filling, and the container can be filled repeatedly in this way, so that the diluted radioactive nuclides can be continuously dispensed into several containers at the same time, and the dose of the dispensed is also selected by the control unit, thereby improving the dispensing efficiency and effect of the device, avoiding the need for staff to frequently adjust the placement position and filling position of the container, making the dispensing process automatic, and reducing the limitations of the device during use; and the data dose required for dispensing is input into the device at one time by the staff at the beginning, so that the device does not need to stop during the dispensing process to wait for the staff to input the dispensing data next time, and can fill the appropriate dose, further improving the dispensing efficiency of the device, and avoiding the continuous opening and closing of the device due to the above phenomenon, so that the device can continue to dispense several containers, improving the dispensing effect of the device, reducing the energy consumption of the device during use, and further reducing the limitations of the device during use; (2) When the syringe fills the solution into the container, the liquid will hit the bottom of the container and cause impact force, which may easily cause the container to shake in the circular buffer ring and the L-shaped base plate. At this time, the weight of the container will increase, causing it to move to the upper limit of the guide groove through the guide cylinder, so that the guide spring is in a buffering state. The buffering force brought by the guide spring and the circular buffer ring can reduce the impact force of the solution on the container, avoiding the container from shaking significantly during the filling process, improving the stability of the device during filling, and avoiding the shaking of the container during filling so that it cannot be aligned with the output end of the syringe, thereby improving the accuracy of the device during the filling process and the filling effect of the device; (3) Several resistance wheels rotate on the inner bottom surface of the experimental hot chamber, which can further limit the rotation of the rotating disc, avoid the rotating disc from shaking during rotation, improve the stability of the rotating disc and the container during rotation, and improve the smoothness of the rotating disc during rotation; it is worth mentioning that when adjusting the position of the container, that is, rotating the container closest to the syringe to the bottom of the syringe output end, the resistance wheel at this time will rotate synchronously with the container at this location and contact the inclined surface of the retaining inclined block, thereby exerting a top-down force on the resistance wheel, so that the U-shaped square seat on the resistance wheel moves on the L-shaped base plate through the positioning slide column, so that the positioning spring is in a buffering state, thereby driving the container to move up, so that the distance between the opening of the container and the output end of the syringe is reduced, avoiding the large impact force caused by the liquid hitting the container during filling, resulting in splashing of the solution, thereby avoiding the splashing of the filled liquid, resulting in a reduction in volume and waste of solution, and further improving the filling effect and efficiency of the device; (4) The two displacement racks move relative to each other and are limitedly moved on the displacement base plate through the displacement cylinder, so that the displacement spring is in a buffering state and cannot be reset, thereby increasing the contact force between the resistance wheel and the top of the retaining inclined block to avoid deviation in the position of the container; at the same time, the two displacement cross plates move relative to each other under the action of the two bent square rods, thereby driving the limit arc block to move under the action of the limit slide column and the limit spring, so that the two limit arc blocks move relative to each other and contact the outer wall of the container, thereby clamping the container to avoid shaking of the container during the filling process, which may cause it to be unable to align with the output end of the syringe and cause leakage, thereby improving the filling effect of the device. At the same time, the buffering property brought by the displacement spring and the energy-absorbing pad can reduce the impact force caused by the shaking of the container during filling, thereby improving the stability of the device during filling and further reducing the limitations of the device during use. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention.

[0018] In the attached picture: Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the structure of the multi-axis displacement device of the present invention; Figure 3 This is an exploded view of the rotating convex ring of the present invention; Figure 4 This is a schematic diagram of the internal structure of the experimental hot chamber of the present invention; Figure 5 This is a schematic diagram of the resistance wheel structure of the present invention; Figure 6 It is a cross-sectional view of the liquid storage tank of the present invention; Figure 7 It is a cross-sectional view of the guide circular groove of the present invention; Figure 8 This is a schematic diagram of the structure of the rotating disk of the present invention; Fig. 9 This is a schematic diagram of the bent square rod structure of the present invention; Fig.10 This is a cross-sectional exploded view of the positioning slide column of the present invention; Fig.11 This is a schematic diagram of the structure of the limiting arc block of the present invention; In the figure: 1. Experimental hot chamber; 2. Rotating motor; 3. Rotating disk; 4. Rotating substrate; 5. Container; 6. L-shaped substrate; 7. Multi-axis displacement device; 8. Liquid storage tank; 9. Syringe; 10. Delivery pipe; 11. Positioning slide column; 12. U-shaped square seat; 13. Resistance round wheel; 14. Retention inclined block; 15. Protective round box; 16. Positioning spring; 17. Rotating convex ring; 18. Rotating block; 19. Circular buffer ring; 20. Circular plate; 21. Guide cylinder; 22. Guide circular groove; 23. Pressure sensor device; 24, guide spring; 25, L-shaped rack; 26, rotating gear; 27, rotating shaft; 28, rotating base plate; 29, rotating bevel gear; 30, driven bevel gear; 31, driven shaft; 32, driven base plate; 33, displacement gear; 34, displacement rack; 35, displacement square plate; 36, displacement cylinder; 37, displacement spring; 38, bent square rod; 39, displacement cross plate; 40, limit sliding column; 41, limit arc block; 42, energy absorbing pad; 43, limit spring; 44, U-shaped pipe. DETAILED DESCRIPTION

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0020] Example, by Figures 1 to 11 The present invention comprises an experimental hot chamber 1; a refilling anti-stop mechanism is arranged on the experimental hot chamber 1, and the refilling anti-stop mechanism is used for continuously dispensing diluted radioactive nuclides for making medicines; the refilling anti-stop mechanism comprises a rotating motor 2 which is arranged on the inner bottom surface of the experimental hot chamber 1 by bolts, and a rotating disc 3 is connected to the output end of the rotating motor 2, and a plurality of rotating substrates 4 are installed on the outer wall of the rotating disc 3, and a container 5 is arranged through the top of the rotating substrate 4, and the container 5 is slidably matched with the rotating substrate 4; an L-shaped substrate 6 corresponding to the number and position of the rotating substrate 4 is arranged at the bottom of the rotating disc 3, and a distance control and splash-stop unit is arranged on the L-shaped substrate 6, and the distance control and splash-stop unit is used for adjusting the height of the container 5 when being dispensed; a multi-axis displacer 7 is connected to the inner wall of the experimental hot chamber 1 by bolts, and a liquid storage tank 8 is installed on the top of the multi-axis displacer 7, and a syringe 9 is installed on the slidable part of the bottom of the multi-axis displacer 7, and the output end of the syringe 9 faces The inner bottom surface of the experimental hot chamber 1; the liquid storage tank 8 is equipped with a delivery pipe 10, which is connected to the syringe 9; the bottom of the rotating disc 3 is equipped with a rotating convex ring 17, and a number of rotating blocks 18 are slidably connected to the rotating convex ring 17, and the several rotating blocks 18 are fixedly arranged on the inner bottom surface of the experimental hot chamber 1; the rotating convex ring 17 is nested in the rotating block 18, and the two are slidably matched; a part of the area of ​​the container 5 is located in the rotating base plate 4; the top of the container 5 is an opening, facing the inner top surface of the experimental hot chamber 1 and located below the syringe 9; the refilling anti-stop mechanism also includes a U-shaped pipe 44, one end of the U-shaped pipe 44 is connected to the side of the top of the syringe 9, and the other end is connected to the side of the bottom of the syringe 9; the first valve is installed on the input end and the output end of the U-shaped pipe 44; the syringe 9 is also provided with a second valve, and the second valve is located between the two first valves; the output end of the syringe 9 is installed with a third valve; After the radioactive nuclide is diluted in the liquid storage tank 8, it enters the syringe 9 through the delivery tube 10 to be filled into the container 5, so that the radioactive nuclide can be packaged and used as a medicine; at the same time, after the current container is packaged, the rotating motor 2 is immediately started, so that its output end drives the rotating disk 3 to rotate, and then drives the several containers 5 on the rotating disk 3 to rotate, so that the filled container 5 rotates to another place and no longer aligns with the syringe 9, so that the next container 5 to be filled is rotated to the right below the syringe 9 for further filling, and the reciprocating operation of the container 5 is continuously performed, so that the diluted radioactive nuclide can be continuously packaged into several containers 5 at the same time, and the packaged dose is also controlled by the control unit. The invention can select the position of the container 5 to be filled, thereby improving the efficiency and effect of the filling of the device, avoiding the need for the staff to frequently adjust the placement position and filling position of the container 5, automating the filling process, and reducing the limitations of the device when in use; it is worth mentioning that when the syringe 9 is in the filling process, the container 5 below the syringe 9 has been filled. At this time, by closing the third valve and the second valve in the syringe 9, the syringe 9 no longer fills the container 5 below. At this time, the rotation of the rotating disk 3 is used to drive the next container 5 to be filled to rotate to the bottom of the syringe 9. In this gap, the liquid storage tank 8 still does not stop delivering the diluted radioactive nuclides to the syringe 9 through the delivery pipe 10, but due to the third valve and the second valve in the syringe 9, the liquid storage tank 8 still does not stop delivering the diluted radioactive nuclides to the syringe 9 through the delivery pipe 10. The second valve is in a closed state, so that the syringe 9 stops the filling operation, but the first valve is in an open state at this time, so that the solution at the top of the syringe 9 enters the U-shaped pipe 44, so as to prolong the time for the solution to flow to the output end of the syringe 9, so as to wait until the container 5 moves to the bottom of the syringe 9. When the container 5 rotates to the bottom of the syringe 9, by opening the third valve, the solution stored in the U-shaped pipe 44 can be dispensed into the container 5 through the output end of the syringe 9, and the data dosage required for dispensing is input into the device at the beginning by the staff at one time, so that the device does not need to stop during the dispensing process to wait for the staff to input the dispensing data next time, and the appropriate dosage can be filled. The packaging efficiency of the device is further improved, and at the same time, the continuous opening and shutting down of the device due to the above phenomenon is avoided, so that the device can continuously perform packaging operations on a plurality of containers 5, thereby improving the packaging effect of the device and reducing the energy consumption of the device when in use, thereby further reducing the limitations of the device when in use; it is worth mentioning that when the rotating disk 3 is rotating, it is made to rotate on a plurality of rotating blocks 18 through the rotating convex ring 17, so that the rotation of the rotating disk 3 can be limited, and the shaking of the rotating disk 3 during rotation can be avoided, which causes the container 5 to be unable to align with the syringe 9, resulting in leakage during packaging, etc., which not only improves the stability of the rotating disk 3 and the container 5 during rotation, but also improves the accuracy of the device during packaging.

[0021] The distance control and splash-stopping unit of this embodiment includes a positioning slide post 11 which is arranged on the top of the L-shaped base plate 6, and the positioning slide post 11 is slidably matched with the L-shaped base plate 6; a U-shaped square seat 12 is installed at one end of the positioning slide post 11 close to the inner bottom surface of the experimental hot chamber 1, and a resistance round wheel 13 is rotatably connected to the U-shaped square seat 12, and a plurality of resistance round wheels 13 are in contact with the inner bottom surface of the experimental hot chamber 1; a retaining inclined block 14 is also installed on the inner bottom surface of the experimental hot chamber 1, and the retaining inclined block 14 is of a circular ring design and is located directly below the output end of the syringe 9, and the retaining inclined block 14 is coaxial with the center of the rotating disk 3; the The two sides of the retaining inclined block 14 are designed with inclined surfaces, and the inclined surfaces are located on the rotation path of the resistance circular wheel 13; the end of the positioning slide 11 away from the bottom surface of the experimental hot chamber 1 is installed with a protective circular box 15, and the top of the protective circular box 15 is designed to be open and the opening faces the top surface of the experimental hot chamber 1; a part of the area of ​​the container 5 is located in the protective circular box 15; a positioning spring 16 is sleeved on the positioning slide 11, one end of the positioning spring 16 is fixedly connected to the bottom of the protective circular box 15, and the other end is fixedly connected to the L-shaped base plate 6, and the L-shaped base plate 6 is located between the protective circular box 15 and the U-shaped square seat 12; When the rotating disc 3 drives the container 5 to rotate, the L-shaped base plate 6, the positioning slide column 11 and the U-shaped square seat 12 make the plurality of resistance wheels 13 rotate on the inner bottom surface of the experimental hot chamber 1, so as to further limit the rotation of the rotating disc 3, avoid the rotating disc 3 from shaking during rotation, improve the stability of the rotating disc 3 and the container 5 during rotation, and improve the smoothness of the rotating disc 3 during rotation; it is worth mentioning that when adjusting the position of the container 5, that is, rotating the container 5 closest to the syringe 9 to the bottom of the output end of the syringe 9, the resistance wheel 13 at that location will be synchronously moved with the container 5 at that location It rotates and contacts the inclined surface of the retaining inclined block 14, thereby exerting a force from top to bottom on the resistance circular wheel 13, so that the U-shaped square seat 12 on the resistance circular wheel 13 moves to the upper limit position on the L-shaped base plate 6 through the positioning slide column 11, so that the positioning spring 16 is in a buffering state, thereby driving the container 5 to move upward, so that the distance between the opening of the container 5 and the output end of the syringe 9 is reduced, avoiding the excessive impact force caused by the liquid hitting the container 5 during packaging due to the large distance between the two, resulting in splashing of the solution, etc., thereby avoiding the splashing of the filled liquid, resulting in a reduction in volume and a waste of solution, and further improving the packaging effect and efficiency of the device.

[0022] The protective circular box 15 of this embodiment is also provided with a weight-reducing force component; the weight-reducing force component includes a circular buffer ring 19 provided in the protective circular box 15, and a circular plate 20 is installed at the bottom of the circular buffer ring 19; the container 5 is located in the circular buffer ring 19, and the inner diameter of the circular buffer ring 19 is the same as the outer diameter of the container 5; the side of the circular plate 20 away from the positioning slide 11 is in contact with the bottom of the container 5; the side of the circular plate 20 close to the positioning slide 11 is also provided with a guide cylinder 21; the positioning A guide circular groove 22 having the same diameter as the guide cylinder 21 is provided in the slide column 11, and one side of the guide circular groove 22 extends to the top of the positioning slide column 11; a part of the guide cylinder 21 is located in the guide circular groove 22; a pressure sensor 23 is provided on the inner bottom surface of the protective circular box 15; a guide spring 24 is sleeved on the guide cylinder 21, one end of the guide spring 24 is connected to the bottom of the circular plate 20, and the other end is connected to the pressure sensor 23; the circular buffer ring 19 is slidably matched with the protective circular box 15; The container 5 to be packaged is placed on the L-shaped substrate 6, so that the bottom of the container 5 passes through the L-shaped substrate 6 and enters the circular buffer ring 19. When the syringe 9 fills the solution into the container 5, the liquid will hit the bottom of the container 5 and cause impact force thereon, which may easily cause the container 5 to shake in the circular buffer ring 19 and the L-shaped substrate 6. At this time, the weight of the container 5 will increase, causing it to move to the upper limit position in the guide groove 22 through the guide cylinder 21, so that the guide spring 24 is in a buffering state. The buffering force brought by the guide spring 24 and the circular buffer ring 19 can reduce the impact force of the solution on the container 5, avoid the container 5 from shaking significantly during the packaging process, improve the stability of the device during filling, avoid the container 5 shaking during filling so that it cannot be aligned with the output end of the syringe 9, improve the accuracy of the device during the packaging process, and the packaging effect of the device.

[0023] The U-shaped square seat 12 of the present embodiment is also provided with a positioning and straightening assembly; the positioning and straightening assembly includes an L-shaped rack 25 arranged on the side of the U-shaped square seat 12, the L-shaped rack 25 is meshedly connected with a rotating gear 26, a rotating shaft 27 is installed on the rotating gear 26, two rotating base plates 28 are symmetrically installed on the rotating shaft 27, and the rotating base plate 28 is arranged on the rotating base plate 4; rotating bevel gears 29 are installed at both ends of the rotating shaft 27, the rotating bevel gear 29 is meshedly connected with a driven bevel gear 30, a driven shaft 31 is installed on the driven bevel gear 30, a driven base plate 32 is installed at one end of the driven shaft 31 away from the driven bevel gear 30, and the driven base plate 32 is arranged on the rotating base plate 28; a displacement gear 33 is also installed on the driven shaft 31, the displacement gear 33 is meshedly connected with a displacement rack 34, two displacement square plates 35 are symmetrically installed on the displacement rack 34, and the two displacement square plates 35 The opposite surfaces are commonly connected with a displacement cylinder 36; a displacement base plate is slidably connected to the displacement cylinder 36, and the displacement base plate is arranged on the driven base plate 32; a displacement spring 37 is sleeved on the displacement cylinder 36, one end of the displacement spring 37 is connected to the displacement square plate 35, and the other end is connected to the displacement base plate; a bending square rod 38 is installed on each of the two displacement racks 34, and the end points of the two bending square rods 38 are both facing the container 5 and a displacement cross plate 39 is also installed, and two limiting slide posts 40 are symmetrically slidably arranged on the displacement cross plate 39, and the ends of the two limiting slide posts 40 close to the container 5 are commonly connected to a limiting arc block 41, and an energy absorbing pad 42 is arranged on the inner side wall of the limiting arc block 41, and the outer side wall of the container 5 is located on the moving path of the energy absorbing pad 42; a limiting spring 43 is sleeved on the limiting slide post 40, and one end of the limiting spring 43 is fixedly connected to the limiting arc block 41, and the other end is fixedly connected to the displacement cross plate 39; When the U-shaped square seat 12 moves upward, it indicates that the container 5 is moving to the bottom of the syringe 9 to wait for the dispensing operation of the device. At this time, the moving U-shaped square seat 12 drives the L-shaped rack 25 to move, so that it meshes with the rotating gear 26 to rotate, and drives the displacement gear 33 to rotate under the action of the rotating shaft 27, the rotating bevel gear 29, the driven bevel gear 30 and the driven shaft 31, so that it meshes with the displacement rack 34 to move, so that the two displacement racks 34 move relative to each other, and are moved on the displacement base plate through the displacement cylinder 36, so that the displacement spring 37 is in a buffer state, so that it cannot be reset, and the contact force between the resistance round wheel 13 and the top of the retaining inclined block 14 is strengthened to prevent the position of the container 5 from being deviated. difference; at the same time, under the action of the two bent square rods 38, the two displacement cross plates 39 move relative to each other, thereby driving the limiting arc block 41 to move under the action of the limiting slide column 40 and the limiting spring 43, so that the two limiting arc blocks 41 move relative to each other and contact the outer wall of the container 5, thereby clamping the container 5 to avoid shaking of the container 5 during the filling process, which may cause it to be unable to align with the output end of the syringe 9 and cause leakage, thereby improving the filling effect of the device. At the same time, the cushioning provided by the displacement spring 37 and the energy absorbing pad 42 can reduce the impact force caused by the shaking of the container 5 during filling, thereby improving the stability of the device during filling, and further reducing the limitations of the device during use.

[0024] The present invention also provides an experimental method of a radionuclide experimental device for laboratory use, comprising the following steps: S1. After being diluted in the liquid storage tank 8, the radioactive nuclide enters the syringe 9 through the delivery tube 10 to be filled into the container 5; S2, start the rotating motor 2 so that its output end drives the rotating disk 3 to rotate; S3, driving the rotating disc 3 and the plurality of containers 5 to rotate, so as to continuously fill the plurality of containers 5.

[0025] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0026] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A radionuclide experimental device for laboratory use, comprising an experimental hot chamber (1); characterized in that: The experimental hot chamber (1) is provided with a refilling anti-stop mechanism, which is used for continuously dispensing diluted radioactive nuclides to prepare medicines; the refilling anti-stop mechanism comprises a rotating motor (2) which is bolted to the inner bottom surface of the experimental hot chamber (1); a rotating disc (3) is connected to the output end of the rotating motor (2); a plurality of rotating base plates (4) are mounted on the outer side wall of the rotating disc (3); a container (5) is provided through the top of the rotating base plate (4); the container (5) and the rotating base plate (4) are slidably matched; the bottom of the rotating disc (3) is provided with a rotating base plate (4) which is connected to the rotating base plate (4); The number and position of L-shaped substrates (6) are corresponding, and a distance control and splash-stop unit is arranged on the L-shaped substrate (6), and the distance control and splash-stop unit is used to adjust the height of the container (5) when being packaged; a multi-axis displacement device (7) is connected to the inner wall of the experimental hot chamber (1) by bolts, a liquid storage tank (8) is installed on the top of the multi-axis displacement device (7), and a syringe (9) is installed on the slidable part of the bottom of the multi-axis displacement device (7), and the output end of the syringe (9) faces the inner bottom surface of the experimental hot chamber (1); a delivery pipe (10) is installed on the liquid storage tank (8), and the delivery pipe (10) is connected to the syringe (9).

2. A laboratory radionuclide experimental device according to claim 1, characterized in that: The distance control and splash-stopping unit comprises a positioning slide column (11) which is arranged on the top of the L-shaped base plate (6), and the positioning slide column (11) is slidably matched with the L-shaped base plate (6); a U-shaped square seat (12) is installed at one end of the positioning slide column (11) close to the inner bottom surface of the experimental hot chamber (1), and a resistance round wheel (13) is rotatably connected to the U-shaped square seat (12), and a plurality of resistance round wheels (13) are in contact with the inner bottom surface of the experimental hot chamber (1); a retaining inclined block (14) is also installed on the inner bottom surface of the experimental hot chamber (1), and the retaining inclined block (14) is designed as a circular ring and is located directly below the output end of the syringe (9), and the retaining inclined block (14) is coaxial with the center of the rotating disk (3); both sides of the retaining inclined block (14) are designed as inclined surfaces, and the inclined surfaces are located on the rotation path of the resistance round wheel (13).

3. A laboratory radionuclide experimental device according to claim 2, characterized in that: A protective round box (15) is installed at one end of the positioning slide column (11) away from the inner bottom surface of the experimental hot chamber (1), and the top of the protective round box (15) is designed to be open and the opening faces the inner top surface of the experimental hot chamber (1); a partial area of ​​the container (5) is located in the protective round box (15); a positioning spring (16) is sleeved on the positioning slide column (11), one end of the positioning spring (16) is fixedly connected to the bottom of the protective round box (15), and the other end is fixedly connected to the L-shaped base plate (6), and the L-shaped base plate (6) is located between the protective round box (15) and the U-shaped square seat (12).

4. The radionuclide experimental device for laboratory use according to claim 1, characterized in that: A rotating convex ring (17) is installed at the bottom of the rotating disc (3), and a plurality of rotating blocks (18) are slidably connected to the rotating convex ring (17), and the plurality of rotating blocks (18) are fixedly arranged on the inner bottom surface of the experimental hot chamber (1); the rotating convex ring (17) is nested in the rotating block (18), and the two are slidably matched; a partial area of ​​the container (5) is located in the rotating base plate (4); the top of the container (5) is an opening, facing the inner top surface of the experimental hot chamber (1) and located below the syringe (9).

5. The radionuclide experimental device for laboratory use according to claim 3, characterized in that: The protective circular box (15) is also provided with a weight-measured force-reducing component; the weight-measured force-reducing component comprises a circular buffer ring (19) arranged in the protective circular box (15), and a circular plate (20) is installed at the bottom of the circular buffer ring (19); the container (5) is located in the circular buffer ring (19), and the inner diameter of the circular buffer ring (19) is the same as the outer diameter of the container (5); the side of the circular plate (20) away from the positioning slide column (11) is in contact with the bottom of the container (5); and the side of the circular plate (20) close to the positioning slide column (11) is also provided with a guide cylinder (21).

6. A laboratory radionuclide experimental device according to claim 5, characterized in that: The positioning slide column (11) is provided with a guide circular groove (22) having the same diameter as the guide cylinder (21), and one side of the guide circular groove (22) extends to the top of the positioning slide column (11); a partial area of ​​the guide cylinder (21) is located in the guide circular groove (22); a pressure sensor (23) is provided on the inner bottom surface of the protective circular box (15); a guide spring (24) is sleeved on the guide cylinder (21), one end of the guide spring (24) is connected to the bottom of the circular plate (20), and the other end is connected to the pressure sensor (23); the circular buffer ring (19) is slidably matched with the protective circular box (15).

7. A laboratory radionuclide experimental device according to claim 2, characterized in that: The U-shaped square seat (12) is also provided with a positioning and straightening assembly; the positioning and straightening assembly comprises an L-shaped rack (25) provided on the side of the U-shaped square seat (12); the L-shaped rack (25) is meshingly connected with a rotating gear (26); a rotating shaft (27) is mounted on the rotating gear (26); two rotating base plates (28) are symmetrically mounted on the rotating shaft (27); the rotating base plates (28) are arranged on the rotating base plate (4); rotating bevel gears (29) are mounted at both ends of the rotating shaft (27); the rotating bevel gears (29) are meshingly connected with a rotating gear (26) from the rotating shaft (27); A driven bevel gear (30) is provided, and a driven rotating shaft (31) is provided on the driven bevel gear (30); a driven base plate (32) is provided on one end of the driven rotating shaft (31) away from the driven bevel gear (30); the driven base plate (32) is arranged on the rotating base plate (28); a displacement gear (33) is also provided on the driven rotating shaft (31); the displacement gear (33) is meshingly connected with a displacement rack (34); two displacement square plates (35) are symmetrically provided on the displacement rack (34); and opposite surfaces of the two displacement square plates (35) are commonly connected with a displacement cylinder (36).

8. A laboratory radionuclide experimental device according to claim 7, characterized in that: The displacement cylinder (36) is slidably connected to a displacement base plate, which is arranged on the driven base plate (32); a displacement spring (37) is sleeved on the displacement cylinder (36), one end of the displacement spring (37) is connected to the displacement square plate (35), and the other end is connected to the displacement base plate; a bent square rod (38) is installed on each of the two displacement racks (34), the end points of the two bent square rods (38) are both facing the container (5) and a displacement cross plate (39) is also installed on the displacement cross plate (39). Two limit slide posts (40) are symmetrically slidably arranged on the upper side, and one end of the two limit slide posts (40) close to the container (5) is commonly connected to a limit arc block (41), an energy absorbing pad (42) is arranged on the inner side wall of the limit arc block (41), and the outer side wall of the container (5) is located on the moving path of the energy absorbing pad (42); a limit spring (43) is sleeved on the limit slide post (40), one end of the limit spring (43) is fixedly connected to the limit arc block (41), and the other end is fixedly connected to the displacement horizontal plate (39).

9. The radionuclide experimental device for laboratory use according to claim 1, characterized in that: The refilling anti-stop mechanism further comprises a U-shaped pipe (44), one end of the U-shaped pipe (44) being connected to the side surface of the top of the syringe (9), and the other end of the U-shaped pipe (44) being connected to the side surface of the bottom of the syringe (9); a first valve is installed on both the input end and the output end of the U-shaped pipe (44); a second valve is also provided in the syringe (9), the second valve being located between the two first valves; and a third valve is installed on the output end of the syringe (9).

10. An experimental method of a laboratory radionuclide experimental device, using the laboratory radionuclide experimental device as claimed in claim 1, characterized in that: Includes steps: S1. After being diluted in the liquid storage tank (8), the radioactive nuclide enters the syringe (9) through the delivery tube (10) and is filled into the container (5); S2, starting the rotating motor (2) so that its output end drives the rotating disk (3) to rotate; S3, driving the rotating disc (3) and the plurality of containers (5) to rotate, so as to continuously fill the plurality of containers (5).

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