Storage device for accompanying detection sample after CART cell therapy

Abstract

The invention discloses a CART cell therapy accompanying detection sample preservation device, which comprises a box body and a statistical assembly, the statistical assembly comprises a plurality of pairs of rectangular grooves formed in the top end of the box body, a plurality of gauge blocks are slidably clamped in each rectangular groove, a plurality of groups of scribed lines are formed in one side of each gauge block, the bottom ends of the gauge blocks are connected with the inner bottom walls of the rectangular grooves through elastic plates, and the bottom ends of the gauge blocks are connected with the inner bottom walls of the rectangular grooves through the elastic plates. The bottom end of the gauge block is provided with a plurality of wedge-shaped blocks which are uniformly arranged and connected in the vertical direction, one side of each wedge-shaped block is provided with a tooth-shaped plate in a clamping manner, the tooth-shaped plates are slidably clamped in the rectangular grooves through sliding blocks arranged on the two sides, and a control assembly is arranged in the box body; the statistical assembly arranged in the device can be matched with the control assembly to record historical detection data of different detection indexes, so that the sample storage amount required by the device is reduced, meanwhile, the change condition of each current detection index of a patient is more intuitively reflected, and the practicability of the device is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of sample preservation, and more specifically, to a device for preserving samples for detection after CART cell therapy. Background Art

[0002] CAR-T cell therapy, also known as chimeric antigen receptor T cell immunotherapy, uses genetic engineering technology to modify the patient's own T cells in vitro, so that they express "GPS" on the cell membrane that can specifically recognize the target antigen, namely the CAR structure; the CAR-T cells are cultured in vitro to obtain a large number of proliferation and then infused back into the patient's body to play a role in targeted recognition and killing of cancer cells. In the past decade, CAR-T cell therapy has become a very promising treatment for blood tumors and solid tumors.

[0003] However, since patients need to undergo frequent blood tests after a period of time after CAR-T cell therapy in order to evaluate the treatment efficacy, prognosis and guide subsequent treatment in real time, and since there are many test items, a large number and variety of sampling tubes are needed to preserve blood samples. The existing storage devices for test samples after CART cell therapy lack the function of recording historical sample test conditions. Only preserving new samples is difficult to help doctors judge the patient's condition, and storing historical samples will significantly increase the volume and weight of the storage device, thereby reducing the practicability of the device. Summary of the invention

[0004] The present invention provides a storage device for samples detected after CART cell therapy, so as to solve the problem that the storage device for samples detected after CART cell therapy in the prior art lacks the function of recording the historical sample detection conditions, thereby reducing the practicality of the device.

[0005] In order to achieve the above object, the present invention provides the following technical solutions: A storage device for detection samples after CART cell therapy, comprising a box body and a statistical component, wherein a condensing compressor is arranged in the box body, and the statistical component comprises a plurality of pairs of rectangular grooves opened at the top of the box body, wherein a plurality of gauge blocks are slidably clamped in each of the rectangular grooves, and a plurality of groups of engraved lines are opened on one side of each of the gauge blocks, and the bottom end of the gauge block is connected to the bottom wall of the rectangular groove through an elastic plate, and a plurality of wedge blocks evenly arranged and connected in the vertical direction are arranged at the bottom end of the gauge block, a toothed plate is clamped on one side of the wedge block, and the toothed plate is slidably clamped in the rectangular groove through sliders arranged on both sides, and a control component is arranged in the box body.

[0006] Preferably, the control component includes a rotating rod passing through the box body, the free end of the rotating rod is connected to the control rod, one end of the rotating rod is connected to the side wall of the box body through a coil spring, a plurality of cams are coaxially connected to the rotating rod, and the outer edge of the cam is in contact with the smooth side of the toothed plate.

[0007] Preferably, a connecting block is provided at the top of the gauge block, a sliding sleeve is hinged on the gauge block, a sliding rod is slidingly provided in the sliding sleeve, the free end of the sliding rod is sleeved on one side of the adjacent connecting block, and a paddle is provided on the other side of the connecting block.

[0008] Preferably, a fixing hole is formed at one end of each rectangular groove, a buffer seat connected via a first spring is formed on the inner bottom wall of the fixing hole, a conical groove is formed on the buffer seat, and an elastic cushion membrane is formed on the inner wall of the conical groove.

[0009] Preferably, a clamping assembly is provided at the top of the fixing hole, and the clamping assembly includes a first clamping block and a second clamping block provided at the top of the fixing hole, the first clamping block and the second clamping block are arranged opposite to each other, the first clamping block is connected to the box body through a second spring, and the second clamping block is connected to a vertical plate provided at the top of the box body through a third spring.

[0010] Preferably, a first rack connected via an L-shaped plate is provided on one side of the first clamping block, a gear is rotatably provided on the box body, a second rack is provided on one side of the second clamping block, and the gear is meshed with the first rack and the second rack at the same time.

[0011] Preferably, a connecting rod is provided at one end of the first clamping block, the connecting rod is slidably clamped on the outside of the box body, a pull rod is rotatably clamped on the free end of the connecting rod, a pair of swing arms are slidably clamped on the pull rod, and fixed rods are provided at both ends of the box body, the two swing arms are hinged to the free end of the fixed rod at the same time, and the bottom ends of the two swing arms are commonly connected to a pressure plate.

[0012] Preferably, a top cover is rotatably mounted on the top of the box body, side panels are slidably mounted on both sides of the box body, a locking block is provided on a cover plate hinged at one end of the top cover, and the locking block is engaged with the box body.

[0013] The principle and beneficial effects of this technical solution: (1) The statistical component provided in the present invention can cooperate with the control component to record the historical test data of different test indicators, thereby reducing the amount of sample storage required by the device and more intuitively reflecting the changes in the current test indicators of the patient. When using the statistical component, the medical staff needs to select the gauge block whose position needs to be adjusted according to the recorded data batch. After selecting the gauge block, the medical staff selects the rotating rod corresponding to the position of the gauge block and rotates the rotating rod. The toothed plate releases the horizontal sliding restriction. At this time, the selected gauge block can be pulled up by the dial plate provided on the top of the gauge block. When the scale line indication on one side of the gauge block that is flush with the top surface of the box body is equal to the test data, the gauge block is stopped from moving up and the control rod is released. The vertical position of the gauge block where the wedge block is located will be re-locked. The doctor can intuitively observe the historical change trend of the patient on the indicator through the change in the inclination of the slide bar and the sleeve. At the same time, the specific data of the historical test can be directly obtained through the scale line observation, making the device easier to use while reducing the amount of samples required to be stored by the device, thereby improving the practicality of the device.

[0014] (2) The clamping assembly provided in the present invention can clamp the sample tube and prevent the sample tube from being damaged while moving with the device. When the sample tube needs to be fixed, the pressure plate connected to the free end of the swing arm is first pressed down. At this time, the swing arm will rotate along the pull rod, thereby pulling the pull rod backward. The pull rod will pull the connecting rod hinged at one end thereof backward, placing the sample tube in the fixing hole, pressing down the buffer seat connected to the bottom end of the sample tube through the first spring, and then releasing the pressure plate. The first spring and the second spring will drive the first clamp block and the second clamp block to reset, thereby clamping the sample tube.

[0015] (3) The top cover provided in the present invention can cooperate with the side panels to seal the box body. When the box body needs to be used to store samples in batches, the condensing compressor provided in the box body is turned off, the locking block and the box body are released, the top cover is rotated to move the cover plate, and the two side panels are slid and removed at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the structure after the present invention is split; Figure 3 for Figure 2 Schematic diagram of the enlarged structure of the A area in the middle; Figure 4 It is a schematic diagram of the structure after cutting of the present invention; Figure 5 for Figure 4 Schematic diagram of the enlarged structure of the middle B area; Figure 6 for Figure 4 Schematic diagram of the enlarged structure of the middle C region; The figure marks in the drawings of the specification include: 1, locking block; 2, top cover; 3, box body; 4, side plate; 5, gear; 6, control rod; 7, rotating rod; 8, cam; 9, conical groove; 10, first spring; 11, rectangular groove; 12, first rack; 13, L-shaped plate; 14, fixing rod; 15, second spring; 16, connecting rod; 17, pull rod; 18, swing arm; 19, second rack; 20, vertical plate; 21, engraved line; 22, gauge block; 23, third spring; 24, toothed plate; 25, slider; 26, wedge block; 27, elastic plate; 28, second clamping block; 29, first clamping block; 30, fixing hole; 31, pressure plate; 32, sliding rod; 33, sliding sleeve; 34, dial plate; 35, connecting block; 36, buffer seat. DETAILED DESCRIPTION

[0017] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments: Example:

[0018] like Figures 1 to 6 As shown, the present invention provides a storage device for detection samples after CART cell therapy, including a box body 3 and a statistical component, a condensing compressor is arranged in the box body 3, the statistical component includes a plurality of pairs of rectangular grooves 11 opened at the top of the box body 3, and a plurality of gauge blocks 22 are slidably clamped in each rectangular groove 11, and a plurality of groups of scale lines 21 are opened on one side of each gauge block 22. The bottom end of the gauge block 22 is connected to the bottom wall of the rectangular groove 11 through an elastic plate 27, and a plurality of wedge blocks 26 evenly arranged and connected in the vertical direction are arranged at the bottom end of the gauge block 22. A toothed plate 24 is clamped on one side of the wedge block 26, and the toothed plate 24 is slidably clamped in the rectangular groove 11 through sliders 25 arranged on both sides. A control component is arranged in the box body 3.

[0019] like Figure 1 , Figure 3 and Figure 5 As shown, the control assembly includes a rotating rod 7 passing through the box body 3, the free end of the rotating rod 7 is connected to the control rod 6, one end of the rotating rod 7 is connected to the side wall of the box body 3 through a coil spring, and a plurality of cams 8 are coaxially connected to the rotating rod 7, and the outer edge of the cam 8 is in smooth side contact with the toothed plate 26.

[0020] like Figure 5 and Figure 6 As shown, a connecting block 35 is provided at the top of the gauge block 22, a sliding sleeve 33 is hinged on the gauge block 22, a sliding rod 32 is slidably provided in the sliding sleeve 33, the free end of the sliding rod 32 is sleeved on one side of the adjacent connecting block 35, and a dial plate 34 is provided on the other side of the connecting block 35.

[0021] The statistical component can cooperate with the control component to record the historical test data of different test indicators, thereby reducing the amount of sample storage required by the device, and at the same time more intuitively reflecting the changes in the patient's current test indicators. When using the statistical component, medical staff need to select the gauge block 22 that needs to be adjusted according to the recorded data batch, and after selecting the gauge block 22, select the rotating rod 7 corresponding to the position of the gauge block 22, and rotate the rotating rod 7. Since the free end of the rotating rod 7 is connected to the control rod 6, and a plurality of cams 8 are coaxially connected to the rotating rod 7, after the rotating rod 7 is rotated so that the cam 8 does not contact one side of the toothed plate 24, the toothed plate 24 releases the horizontal sliding restriction. At this time, the selected gauge block 22 can be pulled up by the dial plate 34 set at the top of the gauge block 22, and the wedge block 26 set at the bottom of the gauge block 22 is The toothed plate 24 will be squeezed by the inclined surface to move the toothed plate 24 backward. When the number indicated by the scale line 21 on one side of the gauge block 22 that is flush with the top surface of the box body 3 is equal to the test data, the gauge block 22 stops moving up and the control rod 6 is released. The rotating rod 7 will be reset under the elastic force of the coil spring to restrict the movement of the toothed plate 24 again. At this time, the gauge block 22 where the wedge block 26 is located will be locked again in the vertical direction. At the same time, the sliding sleeve 33 and the sliding rod 32 set on the connecting block 35 will also move synchronously. The doctor can intuitively observe the patient's historical change trend in this indicator through the changes in the inclination of the sliding rod 32 and the sliding sleeve 33, and can directly obtain the specific data of the historical test through the scale line 21, making the device easier to use while reducing the amount of samples required to be stored in the device, thereby improving the practicality of the device.

[0022] like Figure 3 and Figure 5 As shown, a fixing hole 30 is formed at one end of each rectangular groove 11, a buffer seat 36 connected via a first spring 10 is formed on the inner bottom wall of the fixing hole 30, a conical groove 9 is formed on the buffer seat 36, and an elastic cushion membrane is formed on the inner wall of the conical groove 9.

[0023] like Figure 1 , Figure 3 and Figure 5 As shown, a clamping assembly is arranged at the top of the fixing hole 30, and the clamping assembly includes a first clamping block 29 and a second clamping block 28 arranged at the top of the fixing hole 30, the first clamping block 29 and the second clamping block 28 are arranged opposite to each other, the first clamping block 29 is connected to the box body 3 through the second spring 15, and the second clamping block 28 is connected to the vertical plate 20 arranged at the top of the box body 3 through the third spring 23.

[0024] like Figure 1 , Figure 3 and Figure 5 As shown, a first rack 12 connected by an L-shaped plate 13 is provided on one side of the first clamp 29, a gear 5 is rotatably provided on the box body 3, and a second rack 19 is provided on one side of the second clamp 28, and the gear 5 is meshed with the first rack 12 and the second rack 19 at the same time.

[0025] like Figure 3 and Figure 5 As shown, a connecting rod 16 is provided at one end of the first clamp 29, and the connecting rod 16 is slidably clamped on the outside of the box body 3. A pull rod 17 is rotatably clamped on the free end of the connecting rod 16, and a pair of swing arms 18 are slidably clamped on the pull rod 17. Fixed rods 14 are provided at both ends of the box body 3. The two swing arms 18 are hinged to the free ends of the fixed rod 14 at the same time, and the bottom ends of the two swing arms 18 are commonly connected to a pressure plate 31.

[0026] The clamping assembly can clamp the sample tube and prevent the sample tube from being damaged while moving with the device. When the sample tube needs to be fixed, the pressure plate 31 connected to the free end of the swing arm 18 is pressed down first. At this time, the swing arm 18 will rotate along the pull rod 17, thereby pulling the pull rod 17 to move backward. The pull rod 17 will pull the connecting rod 16 hinged at one end thereof to move backward, so that the first clamping block 29 will move backward synchronously. At this time, the L-shaped plate 13 set on one side of the first clamping block 29 will drive the first rack 12 to move, and the gear 5 meshing with the first rack 12 will rotate. Since the first rack 12 and the second rack 19 are meshed with the gear 5 at the same time, the second rack 19 will move backward under the drive of the gear 5. At this time, the third spring 23 of the second spring 15 is compressed, the sample tube is placed in the fixing hole 30, and the buffer seat connected to the bottom end of the sample tube through the first spring 10 is pressed down, and then the pressure plate 31 is released. The first spring 10 and the second spring 15 will drive the first clamping block 29 and the second clamping block 28 to reset, thereby clamping the sample tube.

[0027] like Figure 1 As shown, a top cover 2 is rotatably mounted on the top of the box body 3, side panels 4 are slidably mounted on both sides of the box body 3, and a locking block 1 is provided on a cover plate hinged at one end of the top cover 2, which is engaged with the box body 3.

[0028] The top cover 2 can cooperate with the side panels 4 to seal the box body 3. When the box body 3 needs to be used to store samples in batches, the condensing compressor provided in the box body 3 is turned off, the locking block 1 and the box body 3 are released, the top cover 2 is rotated to move the cover plate, and the two side panels 4 are slid and removed at the same time.

[0029] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A storage device for samples detected after CART cell therapy, characterized in that: The invention comprises a box body (3) and a statistical component, wherein a condensing compressor is arranged in the box body (3), and the statistical component comprises a plurality of pairs of rectangular grooves (11) opened at the top of the box body (3), wherein a plurality of gauge blocks (22) are slidably clamped in each of the rectangular grooves (11), and a plurality of groups of engraved lines (21) are opened on one side of each of the gauge blocks (22), and the bottom end of the gauge block (22) is connected to the bottom wall of the rectangular groove (11) through an elastic plate (27), and a plurality of wedge blocks (26) are arranged at the bottom end of the gauge block (22) and are evenly arranged and connected in the vertical direction, and a toothed plate (24) is clamped on one side of the wedge block (26), and the toothed plate (24) is slidably clamped in the rectangular groove (11) through sliders (25) arranged on both sides, and a control component is arranged in the box body (3).

2. A storage device for samples detected after CART cell therapy according to claim 1, characterized in that: The control assembly comprises a rotating rod (7) passing through the box body (3), the free end of the rotating rod (7) being connected to a control rod (6), one end of the rotating rod (7) being connected to a side wall of the box body (3) via a coil spring, a plurality of cams (8) being coaxially connected to the rotating rod (7), and the outer edges of the cams (8) being in contact with the smooth side of the toothed plate (26).

3. A storage device for samples detected after CART cell therapy according to claim 2, characterized in that: A connecting block (35) is arranged at the top of the gauge block (22), a sliding sleeve (33) is hingedly connected to the gauge block (22), a sliding rod (32) is slidingly arranged in the sliding sleeve (33), a free end of the sliding rod (32) is sleeved on one side of the adjacent connecting block (35), and a shift plate (34) is arranged on the other side of the connecting block (35).

4. A storage device for samples detected after CART cell therapy according to claim 3, characterized in that: A fixing hole (30) is formed at one end of each rectangular groove (11); a buffer seat (36) connected via a first spring (10) is formed on the inner bottom wall of the fixing hole (30); a conical groove (9) is formed on the buffer seat (36); and an elastic cushion membrane is formed on the inner wall of the conical groove (9).

5. A storage device for samples detected after CART cell therapy according to claim 4, characterized in that: A clamping assembly is arranged at the top of the fixing hole (30), and the clamping assembly comprises a first clamping block (29) and a second clamping block (28) arranged at the top of the fixing hole (30), the first clamping block (29) and the second clamping block (28) being arranged opposite to each other, the first clamping block (29) and the box body (3) being connected via a second spring (15), and the second clamping block (28) and a vertical plate (20) arranged at the top of the box body (3) being connected via a third spring (23).

6. A storage device for samples detected after CART cell therapy according to claim 5, characterized in that: A first rack (12) connected via an L-shaped plate (13) is provided on one side of the first clamping block (29); a gear (5) is rotatably provided on the box body (3); a second rack (19) is provided on one side of the second clamping block (28); and the gear (5) is meshed with both the first rack (12) and the second rack (19).

7. A storage device for samples detected after CART cell therapy according to claim 6, characterized in that: A connecting rod (16) is provided at one end of the first clamping block (29), and the connecting rod (16) is slidably mounted on the outside of the box body (3). A pull rod (17) is rotatably mounted on the free end of the connecting rod (16), and a pair of swing arms (18) are slidably mounted on the pull rod (17). Fixed rods (14) are provided at both ends of the box body (3), and the two swing arms (18) are hinged to the free ends of the fixed rod (14) at the same time. The bottom ends of the two swing arms (18) are commonly connected to a pressure plate (31).

8. A storage device for samples detected after CART cell therapy according to claim 7, characterized in that: The top of the box body (3) is rotatably clamped with a top cover (2), and both sides of the box body (3) are slidably clamped with side panels (4). A locking block (1) is provided on a cover plate hinged at one end of the top cover (2), and the locking block (1) is clamped with the box body (3).

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