3D-printed prosthesis for repairing large-segment bone defects and manufacturing method and mounting kit of 3D-printed prosthesis for repairing large-segment bone defects

Abstract

The invention discloses a 3D-printed prosthesis for repairing large-segment bone defects and a manufacturing method and an installation kit thereof. The upper end and the lower end of the prosthesis body are connected with a bone defect part and are matched with the bone defect part in size; the prosthesis body is composed of a plurality of porous printing units, the whole prosthesis body is in a tubular shape with two open ends, and annular hollow interlayers with the depth of 10-20 mm are inwards formed in the two end faces respectively; a plurality of reinforcing ribs are arranged on the annular cavity interlayer in the radial direction. A plurality of grooves are formed in the outer surface of the side wall of the middle part of the prosthesis body; the depth of the groove ranges from 1 mm to 3 mm. The pore structures capable of being filled with osteogenesis active substances are arranged at the two ends and the surface of the prosthesis, efficient bone ingrowth is achieved, and the prosthesis and the host bone are stably connected and efficiently fused. The prosthesis supports multiple modes of internal fixation and external fixation, is high in adaptability to physical signs of a patient, and can realize lightweight and accurate positioning of the prosthesis.

Description

Technical Field

[0001] The present invention relates to the technical field of orthopedic medical devices, and in particular to a 3D-printed prosthesis for repairing large bone defects, a manufacturing method thereof, and an installation kit. Background Art

[0002] Large bone defects caused by severe trauma, infection or malignant tumors, especially critical bone defects, require bone transplantation or bone replacement materials for clinical treatment. At present, the bone repair materials used in clinical practice mainly include bone, bioceramics, synthetic polymers and medical metal materials. Autologous bone transplantation has disadvantages such as pain and discomfort in the donor site, secondary bone defects in the donor site, limited available bone volume, and mismatch with the defect morphology. It still cannot meet the repair needs of large long bone defects.

[0003] In recent years, the use of 3D printed degradable metal bone repair materials has attracted more and more attention due to their high mechanical strength, degradability and osteogenic biological activity. For example, the invention patent applications with publication numbers CN 117752473 A and CN 117752472 A disclose two 3D printed degradable long bone defect repair devices and their manufacturing methods, which use the mechanical support and osteogenic activity of 3D printed zinc alloy porous scaffolds to promote the repair of bone defects. The invention patent application with publication number CN 118662281 A discloses a porous 3D printed femoral osteotomy prosthesis and a method of use, which improves the positioning method of the prosthesis, promotes blood drainage during wound healing through drainage holes, and uses an intramedullary rod to penetrate and fix the prosthesis.

[0004] However, 3D printing technology is currently used to manufacture a variety of large bone defect repair scaffolds or prostheses, which solve the problems of mechanical support, osteogenic activity and anti-infection, as well as the prosthesis fixation handle and porous design to increase blood and fluid flow to promote bone ingrowth and contact surface bone fusion. However, it does not fundamentally solve the problem of bone interface fusion and bone ingrowth, that is, it does not solve the problem of fusion stability between the prosthesis and the host bone. Summary of the invention

[0005] Due to the above-mentioned defects in the prior art, the present invention provides a 3D printed prosthesis for repairing large bone defects, a manufacturing method and an installation kit thereof, which solve the problems of the connection firmness between the prosthesis and the host bone, the poor bone ingrowth and bone integration on the surface of the prosthesis after implantation of the existing 3D printed prosthesis, and achieves a strong combination and stability between the prosthesis and the host bone.

[0006] To achieve the above-mentioned object, in a first aspect, the present invention provides a 3D printed prosthesis for repairing a large bone defect, comprising a prosthesis body; the upper and lower ends of the prosthesis body are connected to the bone defect part and match the size of the bone defect part; the prosthesis body is composed of a plurality of porous printing units;

[0007] The prosthesis body is in the shape of a tube with two openings at both ends, and an annular hollow interlayer with a depth of 10-20 mm is respectively opened inward on both ends; the wall thickness of the annular hollow interlayer is 2-5 mm, and a plurality of reinforcing ribs are arranged along the radial direction;

[0008] The outer surface of the side wall in the middle of the prosthesis body is provided with a plurality of grooves; the depth of the grooves is 1-3 mm.

[0009] In the second aspect, the present invention provides an installation kit for a 3D-printed prosthesis for repairing a large bone defect, comprising an intramedullary rod, a screw, a bone growth-promoting active material, and the prosthesis for repairing a large bone defect as described in the first aspect; the annular cavity interlayer of the prosthesis body is filled with the bone growth-promoting active material; the groove is filled with the bone growth-promoting active material; the intramedullary rod passes through the tubular hole of the prosthesis body and is inserted into the host bone to be connected up and down; the screw passes through the host bone and the intramedullary rod to fix the upper and lower ends. The intramedullary rod is a solid or hollow structure, which plays the role of positioning the prosthesis body and fixing the upper and lower ends of the connector. This technical solution uses internal fixation to fix the connection between the prosthesis and the host bone.

[0010] The prosthesis body composed of porous printing units provides effective mechanical support and osteogenic activity; the annular cavity interlayer at both ends of the prosthesis body is filled with bone growth-promoting active materials, which is conducive to bone ingrowth and realizes a firm connection of the prosthesis connection interface; the groove on the outer wall of the prosthesis body is filled with bone growth-promoting active materials, which is conducive to bone ingrowth, realizes bone ingrowth on the prosthesis surface and new bone formation on the entire prosthesis surface, and achieves the effect of complete fusion of new bone and prosthesis more quickly. The depth of the annular cavity interlayer and the thickness of the groove are designed according to the healing cycle of bone fusion to achieve the above technical effects.

[0011] In some embodiments, a first bone plate is provided on one side of the prosthesis body along the axial direction and is integrally formed with the prosthesis body by 3D printing; the top and bottom plate surfaces of the first bone plate respectively extend beyond the prosthesis body, and a first screw hole is provided in the exceeding portion; the first bone plate is a solid structure. With this technical solution, the prosthesis body and the bone plate are integrally formed by 3D printing technology, and the bone plate is a solid structure, which can effectively improve the structural strength of the prosthesis.

[0012] In some embodiments, the outer ring end surface of the annular cavity sandwich extends outwardly with a second bone plate integrally formed with the prosthesis body by 3D printing; the second bone plate has a thickness of 2-3 mm, a width of 10-25 mm, and a height of 30-80 mm, and a second screw hole is provided on its plate surface; the second bone plate is a solid structure. With this technical solution, the bone plate is only extended from the end surface of the annular cavity sandwich, which can reduce the mass of the prosthesis on the one hand, and facilitate the positioning of the host bone during bone setting on the other hand.

[0013] In some embodiments, the cross-section of the groove is rectangular, and the total cross-sectional area of ​​the groove accounts for 5-25% of the surface area of ​​the prosthesis body. With this technical solution, the shape and area ratio of the groove can achieve a better cortical bone growth effect.

[0014] In some embodiments, the annular cavity interlayer of the prosthesis body is filled with bone growth promoting active material; and the groove is filled with bone growth promoting active material.

[0015] In some embodiments, the pore distribution of the printing unit is uniform, or dense at the periphery and sparse in the middle, or the pore structure is divided by reinforcing ribs; the pore size range of the printing unit is 0.1 mm~2 mm, and the porosity range is 50~95%.

[0016] In some embodiments, the structure of the printing unit is selected from one or more of a tetrahedron, an octahedron, a dodecahedron, a spiral icosahedron, a minimal surface structure, an octahedron, and a three-dimensional Kogome.

[0017] In the third aspect, the present invention provides a 3D printed installation kit for a prosthesis for repairing a large bone defect, comprising screws, bone growth promoting active materials, and the prosthesis for repairing a large bone defect as described above; the annular cavity interlayer of the prosthesis body is filled with bone growth promoting active materials; the groove is filled with bone growth promoting active materials; the upper and lower host bones to be connected are respectively placed on the inner side of the bone plate and contact the prosthesis body; screws are used to penetrate the host bone and the screw holes on the bone plate to fix the upper and lower ends. This technical solution uses external fixation to fix the connection between the prosthesis and the host bone.

[0018] In the last aspect, the present invention provides a method for manufacturing a 3D-printed prosthesis for repairing a large bone defect, which is used to manufacture the prosthesis for repairing a large bone defect as described above, comprising the following steps:

[0019] Step S1, using high-resolution CT to scan the large bone defect, determining the length, diameter and shape of the large bone defect after three-dimensional reconstruction, and using the CT results as a reference to model and establish the size and shape of the prosthesis; designing and determining the final printing parameters;

[0020] Step S2, selecting suitable printing metal powder;

[0021] Step S3: Printing the prosthesis on a metal 3D printer using the printing metal powder selected in step S2.

[0022] The use of 3D printing technology to manufacture prostheses has the characteristics of high technical maturity, satisfactory quality, and low manufacturing cost.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] (1) The present invention achieves efficient bone ingrowth by providing pore structures that can be filled with osteogenic active substances at both ends and on the surface of the prosthesis, thereby achieving the effect of stable connection and efficient fusion between the prosthesis and the host bone.

[0025] (2) The prosthesis of the present invention supports multiple methods of internal fixation and external fixation, and has strong adaptability to the patient's physical signs; by adjusting the structural design parameters of the prosthesis, the prosthesis can be lightweight and accurately positioned.

[0026] (3) The prosthesis manufacturing method of the present invention is easy to implement and has low manufacturing cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The present invention and its features, appearance and advantages will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings. The same reference numerals indicate the same parts in all the drawings. The drawings are not drawn completely to scale, and emphasis is placed on illustrating the subject matter of the present invention.

[0028] Figure 1 is a schematic diagram of the three-dimensional structure of the prosthesis in Example 1 of the present invention;

[0029] Figure 2 is a schematic diagram of the front view structure of the prosthesis in Example 1 of the present invention;

[0030] Figure 3 is a schematic diagram of the top view of the prosthesis in Example 1 of the present invention;

[0031] Figure 4 is a schematic diagram of the axial cross-sectional structure of the prosthesis in Example 1 of the present invention;

[0032] Figure 5 This is a schematic diagram of the installation structure of the prosthesis in Example 1 of the present invention;

[0033] Figure 6 is a schematic diagram of the three-dimensional structure of the prosthesis in Example 2 of the present invention;

[0034] Figure 7 This is a schematic diagram of the installation structure of the prosthesis in Example 2 of the present invention;

[0035] Figure 8 is a schematic diagram of the three-dimensional structure of the prosthesis in Example 3 of the present invention;

[0036] Fig. 9 is a schematic diagram of the axial cross-sectional structure of the prosthesis in Example 3 of the present invention;

[0037] Among them, 1. prosthesis body; 11. annular cavity interlayer; 12. reinforcing ribs; 13. grooves; 2. first bone plate; 21. first screw hole; 3. second bone plate; 31. second screw hole; 4. intramedullary rod; 5. host bone; 6. screws. DETAILED DESCRIPTION

[0038] The exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. It should be understood that all of these exemplary embodiments described are only partial embodiments and examples of the present invention, rather than all of them. On the contrary, these exemplary embodiments are provided so that those skilled in the art can more thoroughly understand the present disclosure and can more completely convey the technical content of the present disclosure to those skilled in the art.

[0039] In the description of the present application, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present application, "plurality" means two or more, unless otherwise clearly and specifically defined.

[0040] Example 1

[0041] See also Figures 1 to 5 , this embodiment provides a 3D printed prosthesis for repairing large bone defects, including a prosthesis body 1; the upper and lower ends of the prosthesis body 1 are connected to the bone defect site, matching the size of the bone defect site; the prosthesis body 1 is composed of a plurality of porous printing units; the prosthesis body 1 is in the shape of a tube with two ends open, and the two ends are respectively provided with an annular cavity interlayer 11 with a depth of 10 to 20 mm; the interlayer wall thickness of the annular cavity interlayer 11 is 2 to 5 mm, and a plurality of reinforcing ribs 12 are provided radially; a plurality of grooves 13 are provided on the outer surface of the side wall in the middle of the prosthesis body 1; the depth of the groove 13 is 1 to 3 mm. More specifically, the depth of the annular cavity interlayer 11 is 15 mm, and bone ingrowth can be achieved in 90 days to achieve bone fusion; the thickness of the interlayer wall is 2 mm, which does not affect the structural strength of the prosthesis, and can be conveniently filled with bone growth-promoting active gel / powder. The depth of the groove 13 is 1.5 mm, and bone ingrowth can be achieved in 45 days to achieve bone cortical growth.

[0042] In some implementations of this embodiment, the cross section of the groove 13 is rectangular, and the total cross-sectional area of ​​the groove accounts for 5-25% of the surface area of ​​the prosthesis body, preferably 12%. With this technical solution, the shape and area ratio of the groove can achieve a better cortical bone growth effect.

[0043] In some implementations of this embodiment, the annular cavity interlayer 11 of the prosthesis body is filled with active bone growth promoting materials; and the groove 13 is filled with active bone growth promoting materials.

[0044] In some implementations of this embodiment, the pore distribution of the printing unit is uniform, or dense around and sparse in the middle, or the pore structure is divided by reinforcing ribs; the pore size range of the printing unit is 0.1mm~2mm, and the porosity range is 50~95%.

[0045] In some implementations of this embodiment, the structure of the printing unit is selected from one or more of a tetrahedron, an octahedron, a dodecahedron, a spiral icosahedron, a minimal surface structure, an octahedron, and a three-dimensional Kogome.

[0046] The manufacturing method of the above-mentioned prosthesis comprises the following steps:

[0047] S1. Use high-resolution CT to scan the large bone defect site, determine the length, diameter and shape of the large bone defect after three-dimensional reconstruction, and use the CT results as a reference to establish the size and shape of the large bone defect repair prosthesis; design and determine the final printing parameters;

[0048] S2. Select appropriate printing metal powder;

[0049] S3, using the printing powder selected in step S2 to print a large bone defect repair prosthesis on a metal 3D printer.

[0050] Furthermore, in step S1, the specific steps of modeling are as follows:

[0051] Based on CT imaging technology, the patient's large bone defect area is three-dimensionally reconstructed to simulate the size and shape of the bone defect area. According to the range and shape of the reconstructed bone defect area, the structure, pore size and pore design of the implant prosthesis for repairing large bone defects are carried out using computer-aided design (CAD) software. The designed three-dimensional structure model data is imported into the control software of the metal 3D printer in STL format.

[0052] Further, in step S2, the optional metal powders include: pure titanium metal powder, titanium aluminum alloy powder, titanium nickel alloy powder, titanium tantalum alloy powder, titanium magnesium alloy powder, titanium strontium alloy powder, titanium gallium alloy powder, titanium zinc alloy powder, tantalum metal powder, tantalum magnesium alloy powder, tantalum calcium alloy powder, tantalum strontium alloy powder, tantalum aluminum alloy powder, tantalum zinc alloy powder, and stainless steel metal powder. Pure titanium metal powder and titanium aluminum alloy powder are preferred.

[0053] Furthermore, in step S3, the 3D printing method includes L-PBF method. Furthermore, the specific steps of 3D printing a large bone defect repair prosthesis with titanium alloy material printing powder are as follows:

[0054] Using an L-PBF machine, an ytterbium laser with a wavelength of 1000 to 1100 nm was selected to print the prosthesis body layer by layer under argon protection, wherein the prosthesis body is a porous bracket with reinforcing ribs, composed of multiple printing units, the pore size range of the printing unit is 0.1 mm to 2 mm, and the porosity range of the printing unit is 50 to 95%.

[0055] See also Figure 5 , installing the above-mentioned prosthesis using the installation kit includes the following steps:

[0056] Step S21, the annular cavity interlayer 11 of the prosthesis body is filled with bone growth promoting active material; the groove 13 is filled with bone growth promoting active material;

[0057] Step S22, the intramedullary rod 4 is passed through the tube hole of the prosthesis body 1, and inserted into the host bone 5 to be connected up and down; the screw 6 is used to penetrate the host bone 5 and the intramedullary rod 4 to fix the upper and lower ends. Specifically, a plurality of screw holes are provided on the part of the intramedullary rod 4 beyond the two ends of the prosthesis body, and the screw holes penetrate the intramedullary rod, and the screws are passed through the intramedullary rod and connected to the two ends of the large bone defect of the host bone. The screw holes and screws 6 are used to fix the intramedullary rod in the normal bone marrow cavity at both ends of the large bone defect of the host bone. The intramedullary rod 4 is a solid or hollow structure, formed by traditional machining technology. The screws are conventional medical fixing screws purchased on the market.

[0058] Example 2

[0059] See also Figure 1 and Figure 6 This embodiment provides a 3D printed prosthesis for repairing large bone defects, and its structure is similar to that of embodiment 1. The difference from embodiment 1 is that one side of the prosthesis body 1 is also provided with a first bone plate 2 which is 3D printed and integrally formed with the prosthesis body along the axial direction; the top and bottom plate surfaces of the first bone plate 2 respectively exceed the prosthesis body 1, and the exceeding part is provided with a first screw hole 21; the first bone plate 2 is a solid structure. With this technical solution, the prosthesis body and the bone plate are integrally formed by 3D printing technology, and the bone plate is a solid structure, which can effectively improve the structural strength of the prosthesis. The contact between the prosthesis body and the bone plate can be set to a smooth transition, and the bone plate is obtained by extending the reinforcing ribs inside the prosthesis body.

[0060] The prosthesis manufacturing method of this embodiment is similar to the manufacturing method in Example 1, and the difference from Example 1 is that the printing unit of the first bone plate 2 is a solid structure.

[0061] See also Figure 7 , installing the above-mentioned prosthesis using the installation kit includes the following steps:

[0062] Step S31, the annular cavity interlayer 11 of the prosthesis body is filled with bone growth promoting active material; the groove 13 is filled with bone growth promoting active material;

[0063] Step S32: Place the upper and lower host bones 5 to be connected on the inner side of the first bone plate 2, respectively, to contact the prosthesis body 1; and use screws 6 to penetrate the host bone 5 and the first screw holes 21 on the bone plate to fix the upper and lower ends. The screws are conventional medical fixing screws purchased on the market.

[0064] Example 3

[0065] See also Figure 1 , 8 9. This embodiment provides a 3D printed prosthesis for repairing large bone defects, which has a similar structure to that of embodiment 1. The difference from embodiment 1 is that a second bone plate 3 integrally formed with the prosthesis body by 3D printing is extended outward from the outer ring end surface of the annular cavity sandwich 11; the second bone plate 3 has a thickness of 2-3 mm, a width of 10-25 mm, and a height of 30-80 mm, and a second screw hole 31 is provided on its plate surface; the second bone plate 3 is a solid structure. With this technical solution, the bone plate is only extended from the end surface of the annular cavity sandwich, which can reduce the mass of the prosthesis on the one hand, and facilitate the positioning of the host bone during bone setting on the other hand.

[0066] The prosthesis manufacturing method of this embodiment is similar to the manufacturing method in Example 1, and the difference from Example 1 is that the printing unit of the second bone plate 3 is a solid structure.

[0067] The prosthesis installation steps of this embodiment are similar to those in Embodiment 2.

[0068] From the structure and usage of the above prosthesis and its installation kit, it can be known that the prosthesis body composed of the porous printing unit in the present invention provides effective mechanical support and osteogenic activity; the annular cavity interlayer at both ends of the prosthesis body is filled with bone growth-promoting active materials, which is conducive to bone ingrowth and realizes a firm connection of the prosthesis connection interface; the grooves on the outer wall of the prosthesis body are filled with bone growth-promoting active materials, which is conducive to bone ingrowth, realizes bone ingrowth on the surface of the prosthesis and new bone formation on the entire prosthesis surface, and achieves the effect of complete fusion of new bone and prosthesis more quickly. The prosthesis supports multiple methods of internal fixation and external fixation, and has strong adaptability to the patient's physical signs; by adjusting the structural design parameters of the prosthesis, the effects of lightweight prosthesis and precise positioning can be achieved. The manufacturing method of the prosthesis is easy to implement and the manufacturing cost is low.

[0069] The above describes the preferred embodiments of the present invention. It should be understood that the present invention is not limited to the above-mentioned specific embodiments, and the devices and structures that are not described in detail should be understood to be implemented in a common manner in the art; any technician familiar with the art can use the above-disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments of equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solutions of the present invention are still within the scope of protection of the technical solutions of the present invention.

Claims

1. A 3D printed prosthesis for repairing a large bone defect, comprising a prosthesis body (1); the upper and lower ends of the prosthesis body (1) are connected to the bone defect site and match the size of the bone defect site; the prosthesis body (1) is composed of a plurality of porous printing units; characterized in that: The prosthesis body (1) is in the shape of a tube with two openings at both ends, and an annular hollow interlayer (11) with a depth of 10 to 20 mm is respectively opened inwardly on both ends; the wall thickness of the annular hollow interlayer (11) is 2 to 5 mm, and a plurality of reinforcing ribs (12) are provided along the radial direction; The outer surface of the side wall in the middle of the prosthesis body (1) is provided with a plurality of grooves (13); the depth of the grooves (13) is 1 to 3 mm.

2. The 3D printed prosthesis for repairing large bone defects according to claim 1, characterized in that: A first bone plate (2) is also provided on one side of the prosthesis body (1) along the axial direction and is integrally formed with the prosthesis body (1) by 3D printing; the top and bottom plate surfaces of the first bone plate (2) respectively extend beyond the prosthesis body (1), and a first screw hole (21) is provided in the extending portion; the first bone plate (2) is a solid structure.

3. The 3D printed prosthesis for repairing large bone defects according to claim 1, characterized in that: A second bone plate (3) is extended outwardly from the outer end surface of the annular hollow sandwich (11) and is formed integrally with the prosthesis body (1) by 3D printing; the second bone plate (3) has a thickness of 2 to 3 mm, a width of 10 to 25 mm, and a height of 30 to 80 mm, and a second screw hole (31) is provided on its plate surface; the second bone plate (3) is a solid structure.

4. The 3D printed prosthesis for repairing large bone defects according to any one of claims 1 to 3, characterized in that: The cross section of the groove (13) is rectangular, and the total cross-sectional area of ​​the groove accounts for 5-25% of the surface area of ​​the prosthesis body.

5. The 3D printed prosthesis for repairing large bone defects according to any one of claims 1 to 3, characterized in that: The annular hollow interlayer (11) of the prosthesis body is filled with active bone growth promoting material; and the groove (13) is filled with active bone growth promoting material.

6. The 3D printed prosthesis for repairing large bone defects according to any one of claims 1 to 3, characterized in that: The pore distribution of the printing unit is uniform, or dense at the periphery and sparse in the middle, or the pore structure is divided by reinforcing ribs; the pore diameter range of the printing unit is 0.1mm~2mm, and the porosity range is 50~95%.

7. The 3D printed prosthesis for repairing large bone defects according to claim 6, characterized in that: The structure of the printing unit is selected from one or more of a tetrahedron, an octahedron, a dodecahedron, a spiral icosahedron, a minimal surface structure, an octahedron, and a three-dimensional Kogome.

8. A method for manufacturing a 3D printed prosthesis for repairing a large bone defect, characterized in that: The method for manufacturing a prosthesis for repairing a large bone defect as claimed in any one of claims 1 to 7 comprises the following steps: Step S1, using high-resolution CT to scan the large bone defect, determining the length, diameter and shape of the large bone defect after three-dimensional reconstruction, and using the CT results as a reference to model and establish the size and shape of the prosthesis; designing and determining the final printing parameters; Step S2, selecting suitable printing metal powder; Step S3: Printing the prosthesis on a metal 3D printer using the printing metal powder selected in step S2.

9. A 3D printed installation kit for a prosthesis for repairing a large bone defect, characterized in that: The invention comprises an intramedullary rod (4), a screw, a bone growth promoting active material and a prosthesis for repairing a large bone defect as claimed in claim 1; the annular cavity interlayer (11) of the prosthesis body (1) is filled with the bone growth promoting active material; the groove (13) is filled with the bone growth promoting active material; the intramedullary rod (4) passes through the tubular hole of the prosthesis body (1) and is inserted up and down into the host bone to be connected; the screw passes through the host bone and the intramedullary rod (4) to fix the upper and lower ends.

10. A 3D printed installation kit for a prosthesis for repairing a large bone defect, characterized in that: The invention comprises screws, bone growth promoting active materials and a prosthesis for repairing a large bone defect as claimed in claim 2 or 3; the annular cavity interlayer (11) of the prosthesis body (1) is filled with bone growth promoting active materials; the groove (13) is filled with bone growth promoting active materials; the upper and lower host bones to be connected are respectively placed on the inner side of the bone plate and contact the prosthesis body (1); and the upper and lower ends are fixedly connected by screws penetrating the screw holes on the host bone and the bone plate.

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