A contrast agent injection device and a usage method

Abstract

The present invention discloses a contrast agent injection device and a using method, relating to the technical field of contrast agent injection. For this contrast agent injection device, the air cylinder extracts part of the physiological saline through an injection member. Additionally, the injection member is attached to the microfiltration membrane assembly. Regardless of the flow direction of the physiological saline, most of the air bubbles will gather near the microfiltration membrane assembly along with the flow direction. Therefore, the air cylinder will also extract the air bubbles synchronously. Then, the physiological saline mixed with gas is rapidly filled into the auxiliary cylinder, enabling the gas to mix with the flowing physiological saline again. By repeating these steps, microbubbles are formed, thereby preparing a microbubble contrast agent, solving the problem in the prior art that when preparing a microbubble contrast agent, the mixing of gas and physiological saline is uneven. Although the size of the air bubbles can be made uniform, there may be a problem of overly large air bubbles.

Description

Technical Field

[0001] The present invention relates to the technical field of contrast agent injection, and specifically to a contrast agent injection device and a using method thereof. Background Art

[0002] A contrast agent is a substance used to enhance the contrast of medical images. By changing the absorption, reflection, or scattering characteristics of certain components in the human body (such as blood vessels, organs, etc.) for imaging signals (such as X-rays, ultrasounds, magnetic resonance signals, etc.), tissues and lesions that were originally difficult to distinguish can be clearly displayed on the imaging images. Classified by physical state, it can include liquid contrast agents, solid contrast agents, and gas contrast agents.

[0003] The Chinese invention patent with the publication number CN108744113B discloses an automatic contrast agent synthesis and injection device. By setting the structural connection between the first air pump, the second air pump, the first electromagnetic air valve, the second electromagnetic air valve and the first cylinder and the second cylinder, the traditional manual operation of the contrast syringe is converted into an automatic contrast injection device, solving the technical problems of insufficient mixing times of the contrast agent and poor stability of microbubbles; by realizing the automation and standardization of this examination, the mixing frequency and times of the contrast agent are accurately mastered, and at the same time, the microbubbles in the syringe can be made to have uniform size and be more stable, making up for the influence of substandard frequency and insufficient times during manual operation, thereby improving the accuracy and repeatability of the contrast examination.

[0004] However, when preparing the microbubble contrast agent in the above-mentioned prior art, there is a problem that the gas and physiological saline are not evenly mixed. Although the bubble size can be made uniform, there may be a problem of too large bubbles. Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the present invention provides a contrast agent injection device and a using method thereof, solving the problem that when preparing the microbubble contrast agent in the prior art, the gas and physiological saline are not evenly mixed. Although the bubble size can be made uniform, there may be a problem of too large bubbles.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: A contrast agent injection device includes an injection cylinder. The bottom of the surface of the injection cylinder is connected with a liquid injection pipe through a connection valve, and the bottom of the surface of the injection cylinder is also connected with a sampling pipe through a connection valve; the bottom end of the injection cylinder is connected with a contrast agent classification and outflow assembly, and the contrast agent classification and outflow assembly is used for classifying and diverting pure liquid contrast agents and solid-liquid mixed contrast agents; the top of the injection cylinder is connected with two auxiliary cylinders through a diverter; the surface of the auxiliary cylinder is connected with a mixing and injection assembly, and the mixing and injection assembly is used for mixing additional materials into physiological saline to prepare a contrast agent.

[0007] The auxiliary cylinder comprises a reciprocating part and a receiving part, the mixed material injection assembly is connected to the receiving part, the bottom of the reciprocating part is movably connected to the top of the receiving part, two packaging rings are connected to the surface of the receiving part, the packaging rings are used to package the connection position between the reciprocating part and the receiving part, and the receiving part is connected to the diverter; a suction assembly is arranged inside the auxiliary cylinder, and an air pipe is connected to the surface of the injection cylinder through a connecting valve, and the air pipe and the suction assembly are used to make the physiological saline injected through the injection tube reciprocate in the injection tube and the auxiliary cylinder, so that the physiological saline is mixed with the additional material; the sampling tube is used to send the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device.

[0008] It also includes: a support frame and a cleaning cylinder, wherein the support frame is connected to a cleaning structure for cleaning the syringe, and when the cleaning structure cleans the syringe, the cleaning structure is connected to the receiving part through the cleaning cylinder; a limiting sleeve is movably sleeved on the surface of the syringe, and the limiting sleeve is fixedly connected to the support frame.

[0009] Furthermore, the contrast agent classification outflow component includes a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure, the syringe includes a columnar portion and an injection portion, the columnar portion is fixedly connected to the injection portion, and a first solenoid valve is fixedly connected to the outlet of the injection portion; the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion, and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve; the pure liquid contrast agent outflow structure is movably arranged inside the columnar portion.

[0010] Furthermore, the solid-liquid mixed contrast agent outflow structure includes a first electrically controlled valve and an outflow piece, wherein the first electrically controlled valve is fixedly connected to the surface of the columnar portion, and one end of the outflow piece is fixedly connected to the position of the columnar portion corresponding to the first electrically controlled valve; the other end of the outflow piece is fixedly connected to a connecting pipe, and the surface of the connecting pipe is fixedly connected to a second electrically controlled valve, one end of the connecting pipe is fixedly connected to the outlet of the first solenoid valve, and the other end of the connecting pipe is fixedly connected to the second solenoid valve; the top of the outflow piece is fixedly connected to an exhaust valve, and the exhaust valve is used to connect to an external exhaust device.

[0011] Further, the pure liquid contrast agent outflow structure includes a movable member, on the surface of which there are apertures and grooves, and a third electronic control valve is fixedly connected inside the apertures and grooves; on the surface of the movable member, there is also a placement groove, the inner side wall of which is movably connected to a guide post, one end of the guide post is fixedly connected to an apertures and grooves plate, on the surface of the apertures and grooves plate, there is a plug post, and the surface of the plug post is movably connected to the inner side wall of the apertures and grooves; at the bottom of the movable member, there is a wireless battery module fixedly connected, the wireless battery module is fixedly connected to an electromagnet, and the electromagnet is connected to the guide post; a return spring is sleeved on the surface of the guide post, one end of the return spring is fixedly connected to the surface of the apertures and grooves plate, and the other end of the return spring is fixedly connected to the surface of the movable member.

[0012] Further, the pure liquid contrast agent outflow structure is arranged above the trachea, the suction assembly includes a piston member and a threaded rod, the piston member is arranged above the mixing and injection assembly, and one end of the threaded rod is movably connected to the piston member; the other end of the threaded rod movably penetrates through the top of the auxiliary cylinder and is threadedly connected to a first straight gear, the first straight gear is movably connected to the auxiliary cylinder through a bearing, the top of the auxiliary cylinder is connected to a second straight gear through a fixing plate, the second straight gear is fixedly connected to a rotating motor, and the first straight gear meshes with the second straight gear; the piston member includes a piston column, a flexible connecting portion and a lifting portion, the piston column is fixedly connected to one end of the flexible connecting portion, the other end of the flexible connecting portion is fixedly connected to the lifting portion, and the lifting portion is movably connected to one end of the threaded rod.

[0013] Further, the mixing and injection assembly includes an air cylinder and two injection structures, the two injection structures are respectively connected to two receiving portions, and an air inlet valve is fixedly connected to the air cylinder; the injection structure includes a delivery pipe and two control valves connected to the delivery pipe, the end of the delivery pipe away from the control valves is connected to the air cylinder through a on-off valve, and the control valves are connected to an injection member; two microfiltration membrane assemblies are fixedly connected inside one of the receiving portions, and the two injection members are located between the two microfiltration membrane assemblies; the surface of the delivery pipe is connected to an auxiliary pipe through a shut-off valve.

[0014] Further, the injection member includes an annular pipe and an injection needle, the injection needle is fixedly connected to the annular pipe, the injection needle penetrates into the inside of the receiving portion, and the annular pipe is fixedly connected to the surface of the receiving portion.

[0015] Furthermore, the cleaning structure includes a liquid storage tank, which is fixedly installed on the top of the support frame, and a water pump is fixedly connected to one side of the liquid storage tank, and the water inlet end of the water pump is fixedly connected to a liquid inlet pipe; when the injection cylinder 1 is cleaned, the end of the liquid inlet pipe away from the water pump is connected to the connecting pipe through a sealing bearing; the interior of the liquid storage tank is fixedly connected to a driving motor, and the driving motor is transmission-connected to a threaded column through a gear box, and a movable plate is threadedly sleeved on the surface of the threaded column, and the surface of the movable plate is movably connected to the inner wall of the liquid storage tank, and the interior of the liquid storage tank is fixedly connected to a connecting column that movably passes through the movable plate; a liquid inlet valve and an exhaust valve are respectively provided on the top of the liquid storage tank, and a drain valve is also provided on the surface of the liquid storage tank.

[0016] Furthermore, the tops of the two reciprocating parts are movably connected to the connecting cover, the top of the connecting cover is provided with a through hole, the top of the cleaning cylinder is fixedly connected with a cleaning valve, and the size of the cleaning valve is adapted to the size of the through hole; the top of the connecting cover is fixedly connected with a centrifugal motor, the top of the centrifugal motor is fixedly connected with a mounting piece, the bottom of the liquid storage tank is provided with a liquid outlet valve, the bottom of the liquid storage tank is fixedly connected with a circular plate through a fixing column, the bottom of the circular plate is fixedly connected with an L-shaped plate, and the L-shaped plate is fixedly connected to the mounting piece through bolts; the circular plate is connected to the circular ring through a first connecting bearing, the circular ring is connected to the closing plate through a second connecting bearing, the closing plate is fixedly connected to the bottom of the liquid storage tank, a flushing valve is installed at the bottom of the circular ring, and when the injection cylinder is cleaned, the flushing valve is connected to the cleaning valve through a water pipe; the bottom of the circular ring is fixedly connected with a first connecting plate, the top of the connecting cover is fixedly connected with a second connecting plate, and the first connecting plate and the second connecting plate can be connected by screws.

[0017] A method for using a contrast agent injection device is applied to the above-mentioned contrast agent injection device, comprising the following steps: injecting physiological saline into the syringe through an injection tube, and a mixing injection component simultaneously extracting gas in the syringe, and stopping injection after the injection of physiological saline is completed; the suction component and the trachea are in action, and when the trachea injects gas into the syringe, the suction component moves upward to transfer the physiological saline to an auxiliary cylinder, and then the gas in the syringe is discharged through the trachea, and the suction component moves downward, and the physiological saline is transferred from the auxiliary cylinder to the syringe, so that the physiological saline flows back and forth; in the process of the reciprocating flow of the physiological saline, a mixture is injected into the auxiliary cylinder through the mixing injection component to mix the physiological saline with the mixture, wherein the mixture includes gas, radioactive raw materials and solid raw materials; after mixing for a period of time, the sampling tube sends part of the contrast agent into the detection device, and the detection device outputs the detection result. If the detection result is unqualified, the preparation is continued, and if the detection result is qualified, the preparation is stopped; the qualified contrast agent is output through the contrast agent classification outflow component; after the use of the contrast agent is finished, the syringe is cleaned by the cleaning structure.

[0018] The present invention has the following beneficial effects:

[0019] (1). For the contrast agent injection device, the air cylinder extracts part of the physiological saline through the injection member. In addition, the injection member is attached to the microfiltration membrane assembly. Regardless of the flow direction of the physiological saline, most of the air bubbles will gather near the microfiltration membrane assembly along with the flow direction. Therefore, the air cylinder will also extract the air bubbles synchronously. Then, the physiological saline mixed with gas is rapidly filled into the auxiliary cylinder, so that the gas is mixed with the flowing physiological saline again. By repeating these steps, microbubbles are formed, thereby preparing the microbubble contrast agent.

[0020] (2). For the contrast agent injection device, by injecting the microbubble contrast agent and the contrast agent containing solids separately, it can prevent the residual solids from puncturing the microbubbles when there is residue in the cleaning, resulting in the damage of the microbubble contrast agent.

[0021] (3). For the usage method of the contrast agent injection device, by detecting the parameters of the contrast agent, it is determined whether the prepared contrast agent is qualified, so as to determine whether to continue the preparation.

[0022] Of course, it is not necessary for any product implementing the present invention to achieve all the above-mentioned advantages simultaneously. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the overall structure of the contrast agent injection device of the present invention.

[0024] Figure 2 It is a schematic diagram of the structure at the vibrator of the contrast agent injection device of the present invention.

[0025] Figure 3 It is a schematic diagram of the internal structure of the injection cylinder of the contrast agent injection device of the present invention.

[0026] Figure 4 It is a schematic diagram of the structure at the second electromagnetic control valve of the contrast agent injection device of the present invention.

[0027] Figure 5 It is a schematic diagram of the structure at the electromagnet of the contrast agent injection device of the present invention.

[0028] Figure 6 It is a schematic diagram of the structure at the placement groove of the contrast agent injection device of the present invention.

[0029] Figure 7 It is a schematic diagram of the structure at the return spring of the contrast agent injection device of the present invention.

[0030] Figure 8 It is a schematic diagram of the structure at the microfiltration membrane assembly of the contrast agent injection device of the present invention.

[0031] Figure 9Schematic diagram of the structure at the flexible connection part of the contrast agent injection device of the present invention.

[0032] Figure 10 Schematic diagram of the structure at the delivery tube of the contrast agent injection device of the present invention.

[0033] Figure 11 Partial enlarged view of the microfiltration membrane assembly of the contrast agent injection device of the present invention.

[0034] Figure 12 Schematic diagram of the structure at the support frame of the contrast agent injection device of the present invention.

[0035] Figure 13 Schematic diagram of the structure at the connection cover of the contrast agent injection device of the present invention.

[0036] Figure 14 Schematic diagram of the internal structure of the liquid storage tank of the contrast agent injection device of the present invention.

[0037] Figure 15 Partial enlarged view of the receiving part of the contrast agent injection device of the present invention.

[0038] Figure 16 Schematic diagram of the structure at the liquid outlet valve of the contrast agent injection device of the present invention.

[0039] Figure 17 Schematic diagram of the cleaning cylinder of the contrast agent injection device of the present invention.

[0040] Figure 18 Flow chart of the usage method of the contrast agent injection device of the present invention.

[0041] In the figure, 1 is a syringe barrel; 101 is a cylindrical part; 102 is an injection part; 2 is a liquid injection tube; 3 is a sampling tube; 4 is a vibrator; 5 is an auxiliary cylinder; 501 is a reciprocating part; 502 is a receiving part; 6 is an air tube; 7 is an auxiliary tube; 8 is a first solenoid valve; 9 is a first electric control valve; 10 is an outflow part; 11 is a connecting tube; 12 is a second electric control valve; 13 is a second solenoid valve; 14 is an air extraction valve; 15 is a movable part; 16 is a hole groove; 17 is a third electric control valve; 18 is a placement groove; 19 is a guide post; 20 is a hole groove plate; 21 is an insertion post; 22 is a wireless charging battery module; 23 is an electromagnet; 24 is a return spring; 25 is a threaded rod; 26 is a microfiltration membrane assembly; 27 is a first spur gear; 28 is a second spur gear; 29 is a rotating motor; 30 is a piston rod; 31 is a flexible connection part; 32 is a lifting part; 33 is an air cylinder; 34 is an intake valve; 35 is a delivery pipe; 36 is a control valve; 37 is an injection part; 3701 is an annular pipe; 3702 is an injection needle; 38 is a sealing ring; 39 is a support frame; 40 is a cleaning cylinder; 41 is a limit sleeve; 42 is a liquid storage tank; 43 is a water pump; 44 is a liquid inlet pipe; 45 is a driving motor; 46 is a threaded column; 47 is a movable plate; 48 is a connecting column; 49 is a connecting cover; 50 is a perforation; 51 is a cleaning valve; 52 is a centrifugal motor; 53 is a mounting part; 54 is an outlet valve; 55 is a circular plate; 56 is an L-shaped plate; 57 is a ring; 58 is a closing plate; 59 is a flushing valve; 60 is a first connecting plate; 61 is a second connecting plate. Detailed implementation manners

[0042] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0043] In the description of the present invention, it should be understood that the terms "open hole", "upper", "lower", "thickness", "top", "middle", "length", "inner", "periphery", etc. indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation to the present invention.

[0044] Please refer to Figures 1-17The embodiment of the present invention provides a technical solution: a contrast agent injection device, comprising a syringe 1, the bottom of the surface of the syringe 1 is connected to a liquid injection tube 2 through a connecting valve, the bottom of the surface of the syringe 1 is also connected to a sampling tube 3 through a connecting valve, and the surface of the syringe 1 is fixedly connected to a vibrator 4; the bottom end of the syringe 1 is connected to a contrast agent classification outflow component, the contrast agent classification outflow component is used to classify and divert pure liquid contrast agents and solid-liquid mixed contrast agents, and the top of the syringe 1 is connected to two auxiliary cylinders 5 through a diverter; the surface of the auxiliary cylinder 5 is connected to a mixing injection component, the mixing injection component is used to mix additional materials into physiological saline to prepare contrast agents;

[0045] The auxiliary cylinder 5 includes a reciprocating part 501 and a receiving part 502, the mixed material injection assembly is connected to the receiving part 502, the bottom of the reciprocating part 501 is movably connected to the top of the receiving part 502, and two packaging rings 38 are connected to the surface of the receiving part 502. The packaging rings 38 are used to package the connection position between the reciprocating part 501 and the receiving part 502, and the receiving part 502 is connected to the diverter.

[0046] A suction assembly is provided inside the auxiliary tube 5, and an air tube 6 is connected to the surface of the injection tube 1 through a connecting valve. The air tube 6 and the suction assembly are used to make the physiological saline injected through the injection tube 2 flow back and forth in the injection tube 2 and the auxiliary tube 5 to mix the physiological saline with the additional material; the sampling tube 3 is used to deliver the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device.

[0047] It also includes: a support frame 39 and a cleaning cylinder 40. The support frame 39 is connected to a cleaning structure for cleaning the injection cylinder 1. When the cleaning structure cleans the injection cylinder 1, the cleaning structure is connected to the receiving portion 502 through the cleaning cylinder 40. The surface of the injection cylinder 1 is movably sleeved with a limiting sleeve 41, and the limiting sleeve 41 is fixedly connected to the support frame 39.

[0048] Specifically, the contrast agent classification outflow component includes a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure. The syringe 1 includes a columnar portion 101 and an injection portion 102. The columnar portion 101 is fixedly connected to the injection portion 102, and the outlet of the injection portion 102 is fixedly connected to a first solenoid valve 8; the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion 101, and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve 8; the pure liquid contrast agent outflow structure is movably arranged inside the columnar portion 101.

[0049] The outflow structure of the solid-liquid mixed contrast agent includes a first electrically controlled valve 9 and an outflow member 10. The first electrically controlled valve 9 is fixedly connected to the surface of the cylindrical portion 101, and one end of the outflow member 10 is fixedly connected to the position of the cylindrical portion 101 corresponding to the first electrically controlled valve 9; the other end of the outflow member 10 is fixedly connected with a connecting pipe 11, and a second electrically controlled valve 12 is fixedly connected to the surface of the connecting pipe 11. One end of the connecting pipe 11 is fixedly connected to the outlet of the first solenoid valve 8, and the other end of the connecting pipe 11 is fixedly connected to the second solenoid valve 13; an air extraction valve 14 is fixedly connected to the top of the outflow member 10, and the air extraction valve 14 is used to connect with an external air extraction device.

[0050] In this embodiment, for the contrast agent containing solid particles, the outflow structure of the solid-liquid mixed contrast agent is used for injection. The first electrically controlled valve 9 is opened, and at the same time, the injection member 37 injects gas into the auxiliary cylinder 5, and the air extraction valve 14 extracts gas to the outside at the same time, so that the contrast agent containing solid particles fills the outflow member 10. After that, the second electrically controlled valve 12 and the second solenoid valve 13 are opened, and injection can be carried out.

[0051] Two different methods are adopted to prevent the residual solids from piercing the microbubbles due to unclean cleaning, resulting in the damage of the microbubble contrast agent.

[0052] Specifically, the outflow structure of the pure liquid contrast agent includes a movable member 15. A hole groove 16 is formed on the surface of the movable member 15, and a third electrically controlled valve 17 is fixedly connected inside the hole groove 16; a placement groove 18 is also formed on the surface of the movable member 15, and the inner side wall of the placement groove 18 is movably connected with a guide post 19. One end of the guide post 19 is fixedly connected with a hole groove plate 20, and a plug post 21 is fixedly connected to the surface of the hole groove plate 20. The surface of the plug post 21 is movably connected with the inner side wall of the hole groove 16; the bottom of the movable member 15 is fixedly connected with a wireless rechargeable battery module 22, and the wireless rechargeable battery module 22 is fixedly connected with an electromagnet 23, and the electromagnet 23 is connected with the guide post 19; a return spring 24 is sleeved on the surface of the guide post 19, one end of the return spring 24 is fixedly connected to the surface of the hole groove plate 20, and the other end of the return spring 24 is fixedly connected to the surface of the movable member 15.

[0053] In this embodiment, at this time, the first solenoid valve 8 is opened, and the auxiliary pipe 7 on the auxiliary cylinder 5 without the microfiltration membrane assembly 26 injects air into the auxiliary cylinder 5 at the same time. The electromagnet 23 is powered off by the wireless rechargeable battery module 22. Under the action of the return spring 24, the guide post 19 drives the hole groove plate 20 and the plug post 21 to move upward, so that the hole groove 16 is exposed, the third electrically controlled valve 17 is opened, and the second solenoid valve 13 is opened. First, an air extraction device is connected to the bottom of the connecting pipe 11 to quickly extract the gas in the injection portion 102 to prevent the gas from moving upward and damaging the microbubbles. Then, the connecting pipe 11 is connected to the syringe, and the microbubble contrast agent can flow out of the injection cylinder 1, and injection can be carried out.

[0054] Specifically, the pure liquid contrast agent outflow structure is arranged above the trachea 6. The suction assembly includes a piston member and a threaded rod 25. The piston member is arranged above the mixing and injection assembly, and one end of the threaded rod 25 is movably connected to the piston member; the other end of the threaded rod 25 movably penetrates through the top of the auxiliary cylinder 5 and is threadedly connected to the first straight gear 27. The first straight gear 27 is movably connected to the auxiliary cylinder 5 through a bearing. The top of the auxiliary cylinder 5 is connected with a second straight gear 28 through a fixing plate. The second straight gear 28 is fixedly connected to the rotation motor 29, and the first straight gear 27 meshes with the second straight gear 28.

[0055] Specifically, the piston member includes a piston column 30, a flexible connection part 31 and a lifting part 32. The piston column 30 is fixedly connected to one end of the flexible connection part 31, the other end of the flexible connection part 31 is fixedly connected to the lifting part 32, and the lifting part 32 is movably connected to one end of the threaded rod 25.

[0056] In this implementation scheme, in order to reduce the pressure in the auxiliary cylinder 5 when gas is filled, the piston member includes a piston column 30, a flexible connection part 31 and a lifting part 32. When gas is filled into the auxiliary cylinder 5, the internal pressure will increase, and thus the flexible connection part 31 is squeezed by the piston column 30, causing the flexible connection part 31 to be compressed, and pressure reduction can be achieved.

[0057] Specifically, the mixing and injection assembly includes an air cylinder 33 and two injection structures. The two injection structures are respectively connected to two receiving parts 502. An air inlet valve 34 is fixedly connected to the air cylinder 33; the injection structure includes a delivery pipe 35 and two control valves 36 connected to the delivery pipe 35. One end of the delivery pipe 35 away from the control valve 36 is connected to the air cylinder 33 through a on-off valve. The control valve 36 is connected to an injection member 37; two microfiltration membrane assemblies 26 are fixedly connected inside one of the receiving parts 502, and the two injection members 37 are located between the two microfiltration membrane assemblies 26; the surface of the delivery pipe 35 is connected to the auxiliary pipe 7 through a shut-off valve.

[0058] The end of the delivery pipe 35 is sleeved on the input port of the control valve 36. When in use, the end of the delivery pipe 35 can be connected to the input port of the control valve 36, and when not in use, it can be disassembled. Similarly, the connection methods of the trachea 6 and the sampling pipe 3 to the connection valve are also detachable.

[0059] Specifically, the injection member 37 includes an annular pipe 3701 and an injection needle 3702. The injection needle 3702 is fixedly connected to the annular pipe 3701. The injection needle 3702 penetrates into the interior of the auxiliary cylinder 5, and the annular pipe 3701 is fixedly connected to the surface of the receiving part 502.

[0060] In this embodiment, in order to accelerate the generation of microbubbles, the gas cylinder 33 extracts part of the saline through the injection piece 37. In addition, the injection piece 37 is attached to the microfiltration membrane assembly 26. Regardless of the flow direction of the saline, most of the bubbles will gather near the microfiltration membrane assembly 26 along the flow direction, so the gas cylinder 33 will also extract the bubbles synchronously. Then, the saline mixed with gas is filled into the auxiliary cylinder 5 at a high speed, so that the gas is mixed with the flowing saline again, and these steps are repeated to form microbubbles with the gas, thereby preparing a microbubble contrast agent.

[0061] Specifically, the cleaning structure includes a liquid storage tank 42, which is fixedly installed on the top of the support frame 39, and a water pump 43 is fixedly connected to one side of the liquid storage tank 42, and a liquid inlet pipe 44 is fixedly connected to the water inlet end of the water pump 43; when the injection cylinder 1 is cleaned, the end of the liquid inlet pipe 44 away from the water pump 43 is connected to the connecting pipe 11 through a sealed bearing; a driving motor 45 is fixedly connected to the inside of the liquid storage tank 42, and the driving motor 45 is transmission-connected to a threaded column 46 through a gear box, and a movable plate 47 is threadedly sleeved on the surface of the threaded column 46, and the surface of the movable plate 47 is movably connected to the inner wall of the liquid storage tank 42, and a connecting column 48 that movably penetrates the movable plate 47 is fixedly connected to the inside of the liquid storage tank 42; a liquid inlet valve and an exhaust valve are respectively provided on the top of the liquid storage tank 42, and a drain valve is also provided on the surface of the liquid storage tank 42.

[0062] Specifically, the tops of the two reciprocating parts 501 are movably connected to the connecting cover 49, the top of the connecting cover 49 is provided with a through hole 50, the top of the cleaning cylinder 40 is fixedly connected with a cleaning valve 51, and the size of the cleaning valve 51 is adapted to the size of the through hole 50; the top of the connecting cover 49 is fixedly connected with a centrifugal motor 52, the top of the centrifugal motor 52 is fixedly connected with a mounting member 53, the bottom of the liquid storage tank 42 is provided with a liquid outlet valve 54, the bottom of the liquid storage tank 42 is fixedly connected with a circular plate 55 through a fixing column, the bottom of the circular plate 55 is fixedly connected with an L-shaped plate 56, and the L-shaped plate 56 It is fixedly connected to the mounting member 53 by bolts; the circular plate 55 is connected to the circular ring 57 by a first connecting bearing, the circular ring 57 is connected to the closing plate 58 by a second connecting bearing, the closing plate 58 is fixedly connected to the bottom of the liquid storage tank 42, a flushing valve 59 is installed at the bottom of the circular ring 57, when the injection cylinder 1 is cleaned, the flushing valve 59 is connected to the cleaning valve 51 through a water pipe; the bottom of the circular ring 57 is fixedly connected to the first connecting plate 60, the top of the connecting cover 49 is fixedly connected to the second connecting plate 61, and the first connecting plate 60 and the second connecting plate 61 can be connected by screws.

[0063] In this embodiment, the centrifugal motor 52 is started, and the auxiliary cylinder 5 and the syringe barrel 1 are driven to rotate synchronously through the connecting cover 49. The limit sleeve 41 can play a role in limiting. Under the action of centrifugal force, some unqualified impurity particles with a large density and undissolved solid raw materials can quickly settle to the bottom of the syringe barrel 1, realizing preliminary precipitation separation and improving the purity of the contrast agent.

[0064] For the contrast agent containing solid particles, when cleaning, the centrifugal motor 52 is required. The first solenoid valve 8 and the third electric control valve 17 are both closed, and the second electric control valve 12, the second solenoid valve 13 and the first electric control valve 9 are all opened. During the flow of the cleaning liquid, the centrifugal motor 52 is started synchronously. During the process of the cleaning liquid flushing the solid particles, the solid particles will also quickly settle under the action of centrifugal force and enter the inside of the liquid storage tank 42 through the water pump 43. Inside the liquid storage tank 42, filter cotton is installed through the installation cover, which can filter the solid particles.

[0065] A usage method of a contrast agent injection device is applied to the above-mentioned contrast agent injection device, as Figure 18 shown, and includes the following steps: Inject physiological saline into the syringe barrel 1 through the liquid injection tube 2. The mixing injection component simultaneously extracts the gas in the syringe barrel 1. After the injection of physiological saline is completed, stop the injection; The suction component and the air pipe 6 act. When the air pipe 6 injects gas into the syringe barrel 1, the suction component moves upward to transfer the physiological saline to the auxiliary cylinder 5. Then, the gas in the syringe barrel 1 is discharged through the air pipe 6, and the suction component moves downward, and the physiological saline is transferred from the auxiliary cylinder 5 to the syringe barrel 1 to make the physiological saline flow reciprocally; During the reciprocal flow of the physiological saline, the mixing injection component injects the mixture into the auxiliary cylinder 5 to mix the physiological saline with the mixture, where the mixture includes gas, radioactive raw materials and solid raw materials; After mixing for a period of time, the sampling tube 3 sends part of the contrast agent to the detection device, and the detection device outputs the detection result. If the detection result is unqualified, continue the preparation. If the detection result is qualified, stop the preparation; Output the qualified contrast agent through the contrast agent classification outflow component; After the contrast agent is used up, clean the syringe barrel 1 through the cleaning structure.

[0066] When it is necessary to prepare a microbubble imaging agent, the liquid injection tube 2 is connected to the physiological saline bottle, the connection valve is opened, and the physiological saline in the physiological saline bottle is sent into the syringe barrel 1 through the liquid supply device. At the same time, the separator acts to connect the syringe barrel 1 with the auxiliary cylinder 5 containing the microfiltration membrane assembly 26. The separator can be composed of three valves. One ends of the three valves are connected, and the other ends are respectively connected to the syringe barrel 1 and the two auxiliary cylinders 5.

[0067] While the physiological saline enters the interior of the syringe barrel 1, the upper control valve 36 on the delivery pipe 35 connected to the auxiliary cylinder 5 containing the microfiltration membrane module 26 is opened, and at the same time the shut-off valve is opened. The auxiliary pipe 7 is connected to an external air extraction device to extract the gas in the syringe barrel 1, enabling the smooth entry of the physiological saline and preventing excessive pressure in the syringe barrel 1.

[0068] After the physiological saline contacts the injection needle 3702 of the upper injection member 37, the injection of the physiological saline stops. Then the shut-off valve closes, and the control valve 36 also closes. The intake valve 34 is opened, and the air cylinder 33 draws in an appropriate amount of gas. Then the intake valve 34 closes. Both control valves 36 and the on-off valve are opened, and at the same time the physiological saline flows back and forth between the syringe barrel 1 and the auxiliary cylinder 5. The air cylinder 33 injects the gas into the flowing physiological saline through the annular pipe 3701 and the injection needle 3702. There are multiple injection needles 3702 with different lengths, which can achieve uniform gas injection.

[0069] In addition, both injection members 37 are arranged in the middle of the two microfiltration membrane modules 26. The air injected through the injection needle 3702 will generate bubbles and mix in the flowing physiological saline. However, the microfiltration membrane module 26 includes a microfiltration membrane and metal meshes on both sides of the microfiltration membrane. The microfiltration membrane can filter larger bubbles. Therefore, some bubbles will remain between the two microfiltration membrane modules 26, and the flowing physiological saline will squeeze these bubbles, forcing the large bubbles to burst and form microbubbles, which can then pass through the microfiltration membrane module 26.

[0070] To accelerate the generation of microbubbles, the air cylinder 33 extracts part of the physiological saline through the injection member 37. In addition, the injection member 37 is in contact with the microfiltration membrane module 26. Regardless of the flow direction of the physiological saline, most of the bubbles will gather near the microfiltration membrane module 26 along the flow direction. Therefore, the air cylinder 33 will also extract the bubbles synchronously. Then the physiological saline mixed with gas is rapidly filled into the auxiliary cylinder 5, enabling the gas to mix with the flowing physiological saline again. By repeating these steps, the gas forms microbubbles, thus preparing the microbubble contrast agent.

[0071] To relieve the pressure in the auxiliary cylinder 5 when the gas is filled, the piston member includes a piston column 30, a flexible connection portion 31, and a lifting portion 32. When the gas is filled into the auxiliary cylinder 5, the internal pressure will increase, and thus the flexible connection portion 31 is squeezed through the piston column 30, causing the flexible connection portion 31 to be compressed, which can achieve pressure reduction.

[0072] After repeating the above steps for a period of time, it is necessary to detect the microbubbles to determine whether the microbubbles meet the requirements. The detection method is as follows:

[0073] The detection device acquires microbubble data, compares the microbubble data with the calibrated microbubble data stored in the database to obtain a microbubble comparison coefficient. The microbubble data includes microbubble diameter, concentration, and scattering cross-section. The calibrated microbubble data includes calibrated microbubble diameter, calibrated concentration, and calibrated scattering cross-section:

[0074] ;

[0075] In the formula, is the microbubble comparison coefficient, is the microbubble diameter, is the concentration, is the scattering cross-section, is the calibrated microbubble diameter, is the calibrated concentration, is the calibrated scattering cross-section;

[0076] If the microbubble comparison coefficient is greater than the microbubble comparison threshold stored in the database, the detection result is unqualified. If the microbubble comparison coefficient is not greater than the microbubble comparison threshold stored in the database, the detection result is qualified.

[0077] The detection device will acquire three important data of the microbubble contrast agent, namely microbubble diameter, concentration, and scattering cross-section. Then, these actually measured data are compared with the corresponding standard calibrated data stored in the database, calibrated microbubble diameter, calibrated concentration, and calibrated scattering cross-section. The formula comprehensively obtains the microbubble comparison coefficient wb by calculating the deviation degree of the microbubble diameter and concentration respectively, and the relative difference of the scattering cross-section. The formula adopts an exponential function form for the deviation of the microbubble diameter and concentration, and a logarithmic function form for the scattering cross-section, making the detection method very sensitive to the changes of these parameters. Whether it is a small change in the microbubble diameter and concentration, or a relative change in the scattering cross-section, it can cause an obvious change in the microbubble comparison coefficient wb. This sensitivity helps to accurately detect whether the microbubble contrast agent meets the quality requirements and ensure the imaging quality.

[0078] After the detection result is qualified, in order to increase the storage time of the microbubbles, the microbubbles can be mixed with phospholipids so that a layer of phospholipids adheres to the surface of the microbubbles. The upper injection part 37 on the auxiliary cylinder 5 containing the microfiltration membrane module 26 injects air into the auxiliary cylinder 5 through the auxiliary tube 7 on the delivery tube 35. At the same time, the classifier connects another auxiliary cylinder 5 to the injection cylinder 1. This auxiliary cylinder 5 does not contain the microfiltration membrane module 26. The upper injection part 37 on the auxiliary cylinder 5 without the microfiltration membrane module 26 extracts air through the auxiliary tube 7 on the delivery tube 35, so as to transfer the microbubble contrast agent.

[0079] Subsequently, the auxiliary tube 7 on the auxiliary cylinder 5 without the microfiltration membrane module 26 slowly injects phospholipids into the two injection parts 37 on the auxiliary cylinder 5. At the same time, the piston part in the auxiliary cylinder 5 moves upward under the action of the threaded rod 25, and the pure liquid contrast agent outflow structure moves upward under the action of air pressure, realizing the mixing of the flowing microbubble contrast agent and phospholipids. After the microbubble contrast agent performs a reciprocating motion, it returns to the syringe barrel 1 to prepare for injection.

[0080] At this time, the first solenoid valve 8 is opened, and the auxiliary tube 7 on the auxiliary cylinder 5 without the microfiltration membrane module 26 injects air into the auxiliary cylinder 5 simultaneously. The electromagnet 23 is powered off by the wireless charging battery module 22. Under the action of the return spring 24, the guide post 19 drives the hole slot plate 20 and the plug post 21 to move upward, exposing the hole slot 16. The third electric control valve 17 is opened, and the second solenoid valve 13 is opened. First, a gas extraction device is connected to the bottom of the connecting tube 11 to quickly extract the gas in the injection part 102, preventing the gas from moving upward and damaging the microbubbles. Then, the connecting tube 11 is connected to the syringe, and the microbubble contrast agent can flow out of the syringe barrel 1 for injection.

[0081] When the mixed material is a radioactive raw material and a solid raw material, the same method is used to inject physiological saline into the syringe barrel 1, but the auxiliary cylinder 5 without the microfiltration membrane module 26 is connected to the syringe barrel 1. At the same time, the vibrator 4 arranged on the syringe barrel 1 vibrates, vibrating the gas in the physiological saline to flow upward, and thus being sucked away by the injection part 37. After the injection of physiological saline is completed, a radioactive raw material solution and a solid raw material solution are injected into the auxiliary cylinder 5 through the auxiliary tube 7 and mixed during the flow of the physiological saline. At the same time, the air cylinder 33 cooperates to accelerate the mixing.

[0082] Among them, when the mixed material is a solid raw material, the centrifugal motor 52 needs to be used for assistance in the final stage of mixing. Before starting the centrifugal motor 52, first close the connection valve connecting the air tube 6 and the sampling tube 3, then remove the air tube 6 and the sampling tube 3, and then turn off the control valve 36 and remove the delivery tube 35.

[0083] The centrifugal motor 52 starts, drives the auxiliary cylinder 5 and the injection cylinder 1 to rotate synchronously through the connecting cover 49, and the limit sleeve 41 can play a role in limiting. Under the action of centrifugal force, some unqualified impurity particles with a large density and undissolved solid raw materials can quickly settle to the bottom of the injection cylinder 1, realizing preliminary precipitation separation and improving the purity of the contrast agent. For the settled large impurity particles and undissolved solid raw materials, they can be discharged through the outflow structure of the solid-liquid mixed contrast agent. Specifically: the first electric control valve 9 is opened, and at the same time, the injection member 37 injects gas into the auxiliary cylinder 5, and the air extraction valve 14 extracts gas to the outside at the same time, so that the contrast agent containing large impurity particles and undissolved solid raw materials fills the outflow member 10. Then, the second electric control valve 12 and the second solenoid valve 13 are opened, and at the same time, the injection member 37 injects gas into the auxiliary cylinder 5, and this part of the waste liquid can be discharged.

[0084] For radioactive contrast agents, the same injection method as that of microbubble contrast agents can be adopted. For contrast agents containing solid particles, they are injected by using the outflow structure of the solid-liquid mixed contrast agent. The first electric control valve 9 is opened, and at the same time, the injection member 37 injects gas into the auxiliary cylinder 5, and the air extraction valve 14 extracts gas to the outside at the same time, so that the contrast agent containing solid particles fills the outflow member 10. Then, the second electric control valve 12 and the second solenoid valve 13 are opened, and injection can be carried out.

[0085] Two different methods are adopted to prevent the residual solids from piercing the microbubbles when there is residue in the cleaning, resulting in the damage of the microbubble contrast agent.

[0086] After the injection is completed, the residual contrast agent can be cleaned. For microbubble contrast agents and radioactive contrast agents, the same cleaning method can be adopted:

[0087] First, remove the bolts between the L-shaped plate 56 and the mounting member 53, then lift the centrifugal motor 52 and the connecting cover 49 upward and remove the connecting cover 49. Subsequently, remove the limit sleeve 41. The limit sleeve 41 is formed by fixing two symmetrical snap rings with screws. After removing the limit sleeve 41, the two reciprocating parts 501 can be removed. Then, connect the two cleaning cylinders 40 to the two receiving parts 502 respectively, and then install the limit sleeve 41 to fix the cleaning cylinders 40 and the receiving parts 502.

[0088] One of the cleaning cylinders 40 is fixedly connected with a cleaning valve 51. Cover the connecting cover 49 on the two cleaning cylinders 40 so that the cleaning valve 51 passes through the through hole 50, and fix the L-shaped plate 56 and the mounting member 53 with bolts. Then connect the flushing valve 59 and the cleaning valve 51 through a water pipe, and then fixedly connect the first connecting plate 60 and the second connecting plate 61 with screws.

[0089] The cleaning liquid is injected into the liquid storage tank 42 through the liquid inlet valve. The liquid outlet valve 54, the flushing valve 59, and the cleaning valve 51 are all opened. The cleaning liquid enters the cleaning cylinder 40, the receiving part 502, and the syringe 1. The first electromagnetic valve 8, the second electromagnetic valve 13, and the third electric control valve 17 are all opened, and the water pump 43 is started to pump water into the liquid storage tank 42 through the liquid inlet pipe 44. The movable plate 47 divides the liquid storage tank 42 into two parts. The new cleaning liquid is injected through the liquid inlet valve, and the cleaned cleaning liquid enters the other part of the liquid storage tank 42.

[0090] When both parts of the liquid storage tank 42 are filled with the cleaning liquid, the drive motor 45 is started to drive the movable plate 47 to reciprocate. When the movable plate 47 moves towards the direction close to the liquid inlet valve, the new cleaning liquid can be squeezed, so that the cleaning liquid flows quickly. When the movable plate 47 moves towards the direction away from the liquid inlet valve, the cleaned cleaning liquid can be squeezed to accelerate its discharge through the discharge valve.

[0091] It should be noted that by changing the positions of the two cleaning cylinders 40, the two receiving parts 502 can be cleaned.

[0092] For the contrast agent containing solid particles, a centrifugal motor 52 is required for cleaning, and the positions of the two cleaning cylinders 40 are not changed:

[0093] The first electromagnetic valve 8 and the third electric control valve 17 are both closed. The second electric control valve 12, the second electromagnetic valve 13, and the first electric control valve 9 are all opened. During the flow of the cleaning liquid, the centrifugal motor 52 is started synchronously. During the process of the cleaning liquid flushing the solid particles, the solid particles will also quickly settle under the action of centrifugal force and enter the interior of the liquid storage tank 42 through the water pump 43. A filter cotton is installed inside the liquid storage tank 42 through the installation cover to filter the solid particles.

[0094] For radioactive contrast agents and contrast agents containing solid particles, the method for detecting whether they are qualified is as follows:

[0095] The detection device obtains radiation data, compares the radiation data with the radiation reference data stored in the database to obtain a radiation comparison coefficient. The radiation data includes radioactivity, energy, and particle range. The radiation reference data includes reference radioactivity, reference energy, and reference particle range:

[0096] ;

[0097] In the formula, is the radiation comparison coefficient, is the radioactivity, is the energy, is the particle range, is the reference radioactivity, is the reference energy, is the reference particle range, is the natural constant;

[0098] If the radioactive ratio coefficient is greater than the radioactive ratio threshold stored in the database, the test result is unqualified. If the radioactive ratio coefficient is not greater than the radioactive ratio threshold stored in the database, the test result is qualified.

[0099] The radioactive activity, energy, and particle range of the radiopaque contrast agent, which are three key radiation data, are obtained respectively. Then they are compared with the corresponding reference data, namely the standard radioactive activity, energy, and particle range. The radioactive ratio coefficient fb is calculated through the above formula. The exponential function e and the absolute value operation are used in this formula, aiming to comprehensively consider the deviation degrees of the three parameters from the standard values. As long as the deviation of any one of the parameters from the standard value is large, it will cause the value of the exponential part to increase significantly, thus increasing the radioactive ratio coefficient fb. Finally, the test result is determined to be qualified or not according to the size relationship between fb and the radioactive ratio threshold.

[0100] The detection device obtains particle data, compares the particle data with the particle reference data stored in the database, and obtains the solid ratio coefficient. The particle data includes particle size and density, and the particle reference data includes reference particle size and reference density:

[0101] ;

[0102] In the formula, is the solid ratio coefficient, is the particle size, is the density, is the reference particle size, is the reference density;

[0103] If the solid ratio coefficient is greater than the solid ratio threshold stored in the database, the test result is unqualified. If the solid ratio coefficient is not greater than the solid ratio threshold stored in the database, the test result is qualified.

[0104] The detection device first obtains two key particle data, namely the particle size and density of the solid particle contrast agent. Then, these data are compared with the standard reference particle size and reference density pre-stored in the database. By using a set formula, the degree of difference between the particle size and density and the standard values is comprehensively considered to calculate the solid comparison coefficient gb. In the formula, absolute value operations are used to ensure the non-negativity of the difference between the particle data and the reference data. For the particle size, |gks - gkc| calculates the deviation degree of the actual particle size from the reference particle size; for the density, |gms - gmc| calculates the deviation degree of the actual density from the reference density. The sum of these two deviation degrees serves as the exponent part of the exponential function e, meaning that as long as there is any deviation between the particle size or density and the standard value, the value of the exponent part will increase, resulting in an increase in the solid comparison coefficient gb. Finally, the qualification of the detection result is determined based on the magnitude relationship between gb and the solid comparison threshold.

[0105] It should be noted that in this document, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variation thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device.

[0106] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification. These embodiments are selected and specifically described in this specification to better explain the principles and practical applications of the present invention, so that those skilled in the art can well understand and utilize the present invention. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. A contrast agent injection device, comprising a syringe (1), characterized in that: The bottom of the surface of the injection barrel (1) is connected to a liquid injection tube (2) via a connecting valve, the bottom of the surface of the injection barrel (1) is also connected to a sampling tube (3) via a connecting valve, and a vibrator (4) is fixedly connected to the surface of the injection barrel (1); The bottom end of the syringe (1) is connected to a contrast medium classification outflow component, which is used to classify and divert pure liquid contrast medium and solid-liquid mixed contrast medium. The top of the syringe (1) is connected to two auxiliary cylinders (5) via a diverter. The surface of the auxiliary cylinder (5) is connected to a mixing material injection assembly, and the mixing material injection assembly is used to mix additional materials into physiological saline to prepare a contrast agent; The auxiliary cylinder (5) comprises a reciprocating portion (501) and a receiving portion (502), the mixed material injection assembly is connected to the receiving portion (502), the bottom of the reciprocating portion (501) is movably connected to the top of the receiving portion (502), the surface of the receiving portion (502) is connected to two packaging rings (38), the packaging rings (38) are used to package the connection position between the reciprocating portion (501) and the receiving portion (502), and the receiving portion (502) is connected to the diverter; A suction assembly is provided inside the auxiliary cylinder (5), and a trachea (6) is connected to the surface of the injection cylinder (1) via a connecting valve. The trachea (6) and the suction assembly are used to allow the physiological saline injected through the injection tube (2) to flow back and forth in the injection tube (2) and the auxiliary cylinder (5), so that the physiological saline is mixed with the additional material; The sampling tube (3) is used to deliver the prepared contrast agent into the detection device, and determine whether the preparation is completed based on the detection result of the detection device; Also includes: A support frame (39) and a cleaning cylinder (40), wherein the support frame (39) is connected to a cleaning structure for cleaning the injection cylinder (1), and when the cleaning structure cleans the injection cylinder (1), the cleaning structure is connected to the receiving portion (502) via the cleaning cylinder (40); A limiting sleeve (41) is movably sleeved on the surface of the injection barrel (1), and the limiting sleeve (41) is fixedly connected to the support frame (39); The mixed material injection assembly comprises an air cylinder (33) and two injection structures, the two injection structures are respectively connected to two receiving portions (502), and an air intake valve (34) is fixedly connected to the air cylinder (33); The injection structure comprises a delivery pipe (35) and two control valves (36) connected to the delivery pipe (35); one end of the delivery pipe (35) away from the control valve (36) is connected to the gas cylinder (33) via an on-off valve; and the control valve (36) is connected to an injection member (37); Two microfiltration membrane assemblies (26) are fixedly connected inside one of the receiving parts (502), and the two injection pieces (37) are located between the two microfiltration membrane assemblies (26); The surface of the delivery pipe (35) is connected to the auxiliary pipe (7) via a shut-off valve; The injection member (37) comprises an annular tube (3701) and an injection needle (3702); the injection needle (3702) is fixedly connected to the annular tube (3701); the injection needle (3702) penetrates into the interior of the receiving portion (502); and the annular tube (3701) is fixedly connected to the surface of the receiving portion (502).

2. A contrast agent injection device according to claim 1, characterized in that: The contrast agent classification outflow component comprises a solid-liquid mixed contrast agent outflow structure and a pure liquid contrast agent outflow structure, the syringe (1) comprises a columnar portion (101) and an injection portion (102), the columnar portion (101) is fixedly connected to the injection portion (102), and a first solenoid valve (8) is fixedly connected to the outlet of the injection portion (102); The solid-liquid mixed contrast agent outflow structure is fixedly connected to the outside of the columnar portion (101), and the outlet of the solid-liquid mixed contrast agent outflow structure is fixedly connected to the outlet of the first solenoid valve (8); The pure liquid contrast agent outflow structure is movably arranged inside the columnar portion (101).

3. A contrast agent injection device according to claim 2, characterized in that: The solid-liquid mixed contrast agent outflow structure comprises a first electrically controlled valve (9) and an outflow piece (10), wherein the first electrically controlled valve (9) is fixedly connected to the surface of the columnar portion (101), and one end of the outflow piece (10) is fixedly connected to a position of the columnar portion (101) corresponding to the first electrically controlled valve (9); The other end of the outflow member (10) is fixedly connected to a connecting pipe (11), a surface of the connecting pipe (11) is fixedly connected to a second electrically controlled valve (12), one end of the connecting pipe (11) is fixedly connected to an outlet of the first solenoid valve (8), and the other end of the connecting pipe (11) is fixedly connected to a second solenoid valve (13); The top of the outflow piece (10) is fixedly connected to an air extraction valve (14), and the air extraction valve (14) is used to be connected to an external air extraction device.

4. A contrast agent injection device according to claim 3, characterized in that: The pure liquid contrast agent outflow structure comprises a movable part (15), a hole groove (16) is formed on the surface of the movable part (15), and a third electric control valve (17) is fixedly connected inside the hole groove (16); The surface of the movable part (15) is also provided with a placement groove (18), the inner side wall of the placement groove (18) is movably connected to a guide column (19), one end of the guide column (19) is fixedly connected to a hole groove plate (20), the surface of the hole groove plate (20) is fixedly connected to an insertion column (21), and the surface of the insertion column (21) is movably connected to the inner side wall of the hole groove (16); A wireless charging battery module (22) is fixedly connected to the bottom of the movable part (15), the wireless charging battery module (22) is fixedly connected to an electromagnet (23), and the electromagnet (23) is connected to a guide column (19); A return spring (24) is sleeved on the surface of the guide column (19), one end of the return spring (24) is fixedly connected to the surface of the hole slot plate (20), and the other end of the return spring (24) is fixedly connected to the surface of the movable member (15).

5. A contrast agent injection device according to claim 2, characterized in that: The pure liquid contrast agent outflow structure is arranged above the trachea (6); the suction assembly comprises a piston and a threaded rod (25); the piston is arranged above the mixed material injection assembly; one end of the threaded rod (25) is movably connected to the piston; The other end of the threaded rod (25) movably passes through the top of the auxiliary cylinder (5) and is threadedly connected to the first spur gear (27); the first spur gear (27) is movably connected to the auxiliary cylinder (5) via a bearing; the top of the auxiliary cylinder (5) is connected to a second spur gear (28) via a fixing plate; the second spur gear (28) is fixedly connected to a rotating motor (29); the first spur gear (27) meshes with the second spur gear (28); The piston member comprises a piston column (30), a flexible connection portion (31) and a lifting portion (32); the piston column (30) is fixedly connected to one end of the flexible connection portion (31); the other end of the flexible connection portion (31) is fixedly connected to the lifting portion (32); and the lifting portion (32) is movably connected to one end of the threaded rod (25).

6. A contrast agent injection device according to claim 3, characterized in that: The cleaning structure comprises a liquid storage tank (42), the liquid storage tank (42) being fixedly mounted on the top of the support frame (39), a water pump (43) being fixedly connected to one side of the liquid storage tank (42), and a liquid inlet pipe (44) being fixedly connected to the water inlet end of the water pump (43); When the syringe barrel (1) is cleaned, the end of the liquid inlet pipe (44) away from the water pump (43) is connected to the connecting pipe (11) via a sealing bearing; The interior of the liquid storage tank (42) is fixedly connected to a driving motor (45), the driving motor (45) is transmission-connected to a threaded column (46) via a gear box, a movable plate (47) is threadedly sleeved on the surface of the threaded column (46), the surface of the movable plate (47) is movably connected to the inner side wall of the liquid storage tank (42), and a connecting column (48) movably penetrating the movable plate (47) is fixedly connected to the interior of the liquid storage tank (42); A liquid inlet valve and an exhaust valve are respectively arranged on the top of the liquid storage tank (42), and a drain valve is also arranged on the surface of the liquid storage tank (42).

7. A contrast agent injection device according to claim 6, characterized in that: The tops of the two reciprocating parts (501) are movably connected to the connecting cover (49), the top of the connecting cover (49) is provided with a through hole (50), the top of the cleaning cylinder (40) is fixedly connected with a cleaning valve (51), and the size of the cleaning valve (51) is adapted to the size of the through hole (50); The top of the connection cover (49) is fixedly connected to a centrifugal motor (52), the top of the centrifugal motor (52) is fixedly connected to a mounting member (53), the bottom of the liquid storage tank (42) is provided with a liquid outlet valve (54), the bottom of the liquid storage tank (42) is fixedly connected to a circular plate (55) via a fixing column, the bottom of the circular plate (55) is fixedly connected to an L-shaped plate (56), and the L-shaped plate (56) is fixedly connected to the mounting member (53) via bolts; The circular plate (55) is connected to the circular ring (57) via a first connecting bearing, the circular ring (57) is connected to the closing plate (58) via a second connecting bearing, the closing plate (58) is fixedly connected to the bottom of the liquid storage tank (42), a flushing valve (59) is installed at the bottom of the circular ring (57), and when the syringe (1) is cleaned, the flushing valve (59) is connected to the cleaning valve (51) via a water pipe; A first connecting plate (60) is fixedly connected to the bottom of the circular ring (57), and a second connecting plate (61) is fixedly connected to the top of the connecting cover (49). The first connecting plate (60) and the second connecting plate (61) can be connected by screws.

8. A method for using a contrast medium injection device, applied to a contrast medium injection device according to any one of claims 1 to 7, characterized in that: The following steps are involved: Injecting physiological saline into the syringe (1) through the injection tube (2), and the mixing injection component simultaneously extracts the gas in the syringe (1), and after the injection of the physiological saline is completed, the injection is stopped; The suction assembly and the trachea (6) are in motion. When the trachea (6) injects gas into the syringe (1), the suction assembly moves upward to transfer the saline solution to the auxiliary cylinder (5). After that, the gas in the syringe (1) is discharged through the trachea (6). The suction assembly moves downward to transfer the saline solution from the auxiliary cylinder (5) to the syringe (1), so that the saline solution flows back and forth. In the process of reciprocating flow of the physiological saline, a mixed material is injected into the auxiliary cylinder (5) through the mixed material injection assembly to mix the physiological saline with the mixed material, wherein the mixed material includes gas, radioactive raw materials and solid raw materials; After mixing for a period of time, the sampling tube (3) delivers part of the contrast agent to the detection device, and the detection device outputs the detection result. If the detection result is unqualified, the preparation continues; if the detection result is qualified, the preparation stops; Outputting qualified contrast medium through the contrast medium classification outflow component; After the contrast agent is used, the syringe (1) is cleaned by the cleaning structure.

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