Noninvasive sphygmomanometer for rats

Abstract

The invention belongs to the technical field of rat sphygmomanometers, and particularly relates to a rat noninvasive sphygmomanometer which comprises a sphygmomanometer body, the sphygmomanometer body is provided with a detection mechanism, the detection mechanism comprises a static clamping plate fixedly installed at the bottom of the sphygmomanometer body, and a groove for installing a miniature electric push rod is formed in the bottom of the sphygmomanometer body. A movable clamping plate is fixedly mounted at the output end of the micro electric push rod; the static clamping plate and the movable clamping plate which are made of flexible silica gel materials can softly fix the tail artery of a mouse, and blood flow interference caused by traditional cuff type pressurization is avoided. A miniature high-frequency ultrasonic probe, a light source detector and a dual-wavelength light source detection instrument are used for measuring the blood vessel wall thickness, the blood vessel diameter and the blood flow velocity, a photoplethysmography sensor is used for monitoring pulse waveforms and blood vessel volume changes, and it is ensured that blood vessel anatomy and dynamic signals are stably collected.

Description

Technical Field

[0001] The invention belongs to the technical field of rat sphygmomanometers, in particular to a non-invasive sphygmomanometer for rats. Background Art

[0002] In biomedical research, non-invasive measurement of rat blood pressure is an important means of studying cardiovascular diseases, drug efficacy and physiological changes. A sphygmomanometer is used to monitor rat blood pressure. The commonly used one is the tail artery cuff sphygmomanometer, which measures blood pressure by wrapping a cuff around the rat's tail. When the cuff is inflated, blood flow is blocked. When the cuff pressure is gradually released, the instrument detects changes in blood flow through sensors to calculate blood pressure.

[0003] The traditional cuff-type blood pressure monitor uses a pressurization method, which not only easily interferes with the blood flow in the rat's caudal artery, but also causes unstable measurement data due to the rat's stress response. In addition, the adaptability and accuracy of a single technology (such as photoplethysmography or ultrasound) in small blood vessel measurements are limited, especially in the dynamic monitoring of small arteries in the rat's tail.

[0004] To this end, the present invention provides a non-invasive sphygmomanometer for rats. Summary of the invention

[0005] In order to make up for the deficiencies of the prior art, at least one technical problem raised in the background technology is solved.

[0006] The technical solution adopted by the present invention to solve its technical problems is: a non-invasive sphygmomanometer for rats described in the present invention comprises a sphygmomanometer body, the sphygmomanometer body is provided with a detection mechanism, the detection mechanism comprises a static clamping plate fixedly mounted on the bottom of the sphygmomanometer body, the bottom of the sphygmomanometer body is provided with a groove for mounting a micro-electric push rod, a dynamic clamping plate is fixedly mounted on the output end of the micro-electric push rod, the side of the static clamping plate and the dynamic clamping plate close to each other are made of flexible silicone material, photoelectric volumetric recording sensors are installed in the static clamping plate and the dynamic clamping plate, and the sphygmomanometer body has a built-in Bluetooth module; four pressure sensors are fixedly mounted on the side of the static clamping plate and the dynamic clamping plate close to each other, the four pressure sensors are respectively mounted on the static clamping plate and the dynamic clamping plate in groups of two, light source detectors are respectively mounted on the static clamping plate and the dynamic clamping plate, a dual-wavelength light source detection instrument is fixedly mounted on one side of the dynamic clamping plate, a micro-high-frequency ultrasonic probe is mounted on the dynamic clamping plate, and a display screen is arranged on the sphygmomanometer body.

[0007] Furthermore, the movable clamping plate is provided with a sliding mechanism, and the sliding mechanism includes a through groove on the movable clamping plate, a moving block is slidably connected in the through groove, two support arms are fixedly mounted on the moving block, and the miniature high-frequency ultrasonic probe is rotatably connected to the two support arms; a boss is fixedly mounted on one side of the moving block, a limiting rod is slidably connected in the boss, a fixed disk is fixedly mounted on one end of the limiting rod, a spring is fixedly mounted between the fixed disk and the boss, a plurality of through holes are provided on one side of the movable clamping plate, and a limiting groove is provided on one side of the moving block.

[0008] Furthermore, a positioning mechanism is provided on the limiting rod, and the positioning mechanism includes two positioning rods fixedly connected to the limiting rod, and one side of the boss is provided with a positioning groove matched with the positioning rod.

[0009] Furthermore, a plurality of elastic balls are fixedly mounted on one side of the support arm, the elastic balls are located between the support arm and the miniature high-frequency ultrasonic probe, a hollow ring is fixedly sleeved on the surface of the limit rod, a connecting tube connected to the inside of the ring is fixedly mounted on one end of the fixed plate, and one end of the connecting tube is connected to the plurality of elastic balls.

[0010] Furthermore, an air blowing mechanism is provided in the limiting groove, and the air blowing mechanism includes a hollow elastic block fixedly installed in the storage groove, an air duct connected to the interior is fixedly installed on one side of the elastic block, and an air outlet pipe is fixedly installed on one side of the support arm, and the air outlet pipe is connected to the interior of the air duct; an extension component is provided in the air outlet pipe.

[0011] Furthermore, the extension component includes a slide groove opened in the air outlet pipe, a slider is slidably connected to the slide groove through an elastic rope, a hollow slide tube is fixedly installed on one end of the slider, and two symmetrically arranged end covers are rotatably connected to the slide tube through a torsion spring; a fixing component is arranged in the slide tube.

[0012] Furthermore, the fixing assembly includes an arc-shaped fixing rod fixedly installed on one side of the end cover, the fixing rod is made of rubber, and the fixing rod gradually enlarges from the end close to the end cover to the end away from the end cover. A fixing groove adapted to the fixing rod is opened inside the sliding tube.

[0013] Furthermore, a disinfection mechanism is arranged in the movable splint, and the disinfection mechanism includes a storage groove opened in the movable splint, a disinfection box made of rubber material is installed in the storage groove, a plurality of hollow roll films connected with the interior and with a one-way valve are fixedly installed on one side of the disinfection box, a liquid inlet pipe connected with the interior and with a one-way valve is installed on one side of the disinfection box, a plurality of storage holes are opened on one side of the movable splint, the hollow roll film is in the storage frame, and a pressure plate is arranged on one side of the moving block.

[0014] Furthermore, two fixing plates are fixedly mounted on one side of the moving block, and both ends of the pressing plate are fixedly connected to the two pressing plates respectively, and the pressing plate is in an arc shape.

[0015] Furthermore, a liquid outlet component is provided on the hollow roll membrane, and the liquid outlet component includes a plurality of through holes opened on the hollow roll membrane, a flexible cloth is fixedly installed in the through holes, and a plurality of liquid outlet holes connected to the interior of the hollow roll membrane are opened on the surface of the flexible cloth, and the end of the hollow roll membrane away from the disinfection box is in a closed state.

[0016] The beneficial effects of the present invention are as follows:

[0017] 1. The non-invasive sphygmomanometer for rats described in the present invention is fitted with the rat's tail through a static splint and a dynamic splint. At this time, the pressure sensor can transmit the monitored pressure to the display screen for recording in real time. The static splint and the dynamic splint made of flexible silicone material can gently fix the rat's tail artery, avoiding blood flow interference caused by traditional cuff-type pressurization. A miniature high-frequency ultrasonic probe, a light source detector and a dual-wavelength light source detection instrument are used to measure the vascular wall thickness, vascular diameter and blood flow velocity. The photoelectric volumetric sensor monitors the pulse waveform and vascular volume changes to ensure stable collection of vascular anatomy and dynamic signals. Through the designed structure, when clamping the rat's tail for experiments, the compression of the rat's tail artery can be reduced, and at the same time, the stress response caused by compression to the experimental rat can be effectively avoided, thereby causing inaccurate experimental data. At the same time, the sphygmomanometer body designed in this application uses a combined acoustic and optical technology to significantly improve the measurement accuracy of the rat's tail artery blood pressure and related parameters, reducing the measurement error.

[0018] 2. A non-invasive sphygmomanometer for rats described in the present invention, when the miniature high-frequency ultrasonic probe moves to a suitable position, the limiting rod on the boss is loosened, so that the limiting rod passes through the through hole and enters the limiting groove of the moving block to be fixed, thereby locking the position that the miniature high-frequency ultrasonic probe needs to detect. When the limiting rod slides toward the through hole, it will slide with the collar on the surface, and when the limiting rod enters the through hole with the collar, the gas inside the collar will enter several elastic balls through the connecting pipe, causing the elastic balls to expand rapidly and abut against the miniature high-frequency ultrasonic probe, thereby increasing the friction between the miniature high-frequency ultrasonic probe and the miniature high-frequency ultrasonic probe, making it impossible to rotate easily. The designed sliding mechanism, positioning mechanism and collar can realize the rapid fixation of the miniature high-frequency ultrasonic probe and fine-tune its rotation. Its structure is simple and easy to operate, and it can monitor the rat coccygeal artery more accurately.

[0019] 3. The non-invasive sphygmomanometer for rats described in the present invention allows the limit rod to squeeze the elastic block when entering the limit groove, so that the gas in the elastic block enters the air outlet pipe through the connecting pipe. The end of the sliding tube is close to the miniature high-frequency ultrasonic probe, and the gas in the air outlet pipe is quickly blown to the miniature high-frequency ultrasonic probe through the sliding tube, thereby realizing rapid blowing and cleaning of the miniature high-frequency ultrasonic probe. The designed fixing component will not immediately reset the end cover with the end cover after the sliding tube is reset to the air outlet pipe. Instead, after the experiment is over, the end cover is slowly driven to reset under the action of the torsion spring, thereby facilitating the gas to inflate the elastic block through the sliding tube, the air outlet pipe and the connecting tube. The designed blowing mechanism can realize efficient and rapid cleaning of the miniature high-frequency ultrasonic probe, effectively remove dust and impurities on the surface of the miniature high-frequency ultrasonic probe, ensure that the probe surface is clean and smooth, and help maintain the clarity and accuracy of ultrasonic imaging. At the same time, air blowing cleaning helps to remove surface particles and prevent wear of the miniature high-frequency ultrasonic probe, thereby increasing the service life of the miniature high-frequency ultrasonic probe.

[0020] 4. The non-invasive sphygmomanometer for rats described in the present invention utilizes a moving block to drive the pressing plate and the fixed plate to slide excessively toward the receiving slot, so that the pressing plate squeezes the rubber disinfection box, and the disinfection box in the disinfection box is quickly filled into the hollow roll film, so that the hollow roll film expands and stretches. The disinfectant in the hollow roll film will spray out through a number of liquid outlet holes on a number of flexible cloths, and then quickly disinfect the moving splint and the static splint, so as to facilitate continued use in the next experiment. The designed fixed plate can prevent the pressing plate from completely squeezing the disinfection box, causing the disinfection box to rupture after being over-squeezed. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The present invention will be further described below in conjunction with the accompanying drawings.

[0022] Figure 1 It is a schematic diagram of the three-dimensional structure of the sphygmomanometer body of the present invention;

[0023] Figure 2 It is a schematic diagram of the structure of the sphygmomanometer body in the present invention when viewed from above;

[0024] Figure 3 It is a structural schematic diagram of the movable clamping plate in the present invention;

[0025] Figure 4 It is a schematic diagram of the structure of the through hole in the present invention;

[0026] Figure 5 It is a schematic diagram of the structure of the moving block in the present invention;

[0027] Figure 6 It is a partial cross-sectional structural schematic diagram of the movable clamping plate in the present invention;

[0028] Figure 7 The present invention Figure 3 A schematic diagram of the structure at A;

[0029] Figure 8 The present invention Figure 4 Schematic diagram of the structure at B;

[0030] Fig. 9 It is a schematic diagram of the structure of the limit groove in the present invention;

[0031] Fig.10 It is a partial cross-sectional structural schematic diagram of the air outlet pipe in the present invention;

[0032] Fig.11 It is a structural schematic diagram of the hollow film roll in the present invention in a rolled-up state;

[0033] Fig.12 It is a schematic diagram of the structure of the hollow roll film after stretching in the present invention;

[0034] Fig.13 It is a structural schematic diagram of the collar of the present invention.

[0035] In the figure: 1. Blood pressure monitor body;

[0036] 10. Detection mechanism; 11. Static clamping plate; 12. Moving clamping plate; 13. Groove; 14. Micro electric push rod; 15. Pressure sensor; 16. Light source detector; 17. Dual-wavelength light source detection instrument; 18. Micro high-frequency ultrasonic probe; 19. Display screen;

[0037] 20. Sliding mechanism; 21. Through slot; 22. Moving block; 23. Support arm; 24. Boss; 25. Fixed plate; 26. Limiting rod; 27. Through hole; 28. Limiting slot;

[0038] 30. Positioning mechanism; 31. Positioning rod; 32. Positioning slot;

[0039] 40. Elastic ball;

[0040] 50. Connecting pipe;

[0041] 60. blowing mechanism; 61. elastic block; 62. air guide tube; 63. air outlet tube;

[0042] 64, extension assembly; 641, slideway; 642, slider; 643, elastic rope; 644, slide tube; 645, end cap;

[0043] 65, fixing assembly; 651, fixing rod; 652, fixing slot;

[0044] 70. Sterilization mechanism; 71. Storage slot; 72. Sterilization box; 73. Storage hole; 74. Hollow film roll; 75. Pressing plate; 76. Fixing plate;

[0045] 77, liquid outlet component; 771, through hole; 772, flexible cloth; 773, liquid outlet hole;

[0046] 80. Ring. DETAILED DESCRIPTION

[0047] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0048] like Figures 1 to 13 As shown, a non-invasive sphygmomanometer for rats described in an embodiment of the present invention includes a sphygmomanometer body 1, and the sphygmomanometer body 1 is provided with a detection mechanism 10, the detection mechanism 10 includes a static clamping plate 11 fixedly installed at the bottom of the sphygmomanometer body 1, and a groove 13 for installing a micro electric push rod 14 is opened at the bottom of the sphygmomanometer body 1, and a dynamic clamping plate 12 is fixedly installed at the output end of the micro electric push rod 14, and the surfaces of the static clamping plate 11 and the dynamic clamping plate 12 close to each other are made of flexible silicone material, and photoplethysmography sensors are installed in the static clamping plate 11 and the dynamic clamping plate 12, and the sphygmomanometer body 1 has a built-in Bluetooth module. Four pressure sensors 15 are fixedly installed on the side where the static clamping plate 11 and the movable clamping plate 12 are close to each other. The four pressure sensors 15 are installed in groups of two on the static clamping plate 11 and the movable clamping plate 12 respectively. Light source detectors 16 are installed on the static clamping plate 11 and the movable clamping plate 12 respectively. A dual-wavelength light source detection instrument 17 is fixedly installed on one side of the movable clamping plate 12. A miniature high-frequency ultrasonic probe 18 is installed on the movable clamping plate 12. A display screen 19 is provided on the sphygmomanometer body 1.

[0049] During operation, when conducting experiments on the rat's tail, first apply a small amount of coupling agent to the rat's tail, and use the micro electric push rod 14 to drive the moving splint 12 to move, so that one side of the moving splint 12 fits with the rat's tail. At this time, the static splint 11 and the moving splint 12 fit with the rat's tail. At this time, the pressure sensor 15 can transmit the monitored pressure to the display screen 19 for recording in real time. The static splint 11 and the moving splint 12 made of flexible silicone material can gently fix the rat's tail artery to avoid blood flow interference caused by traditional cuff-type pressurization. The micro high-frequency ultrasonic probe 18, the light source detector 16 and the dual-wavelength light source detection instrument 17 are used to measure the vascular wall thickness, vascular diameter and blood flow velocity. The photoelectric volumetric sensor monitors the pulse waveform and vascular volume changes to ensure stable collection of vascular anatomy and dynamic signals. The above-mentioned collected signals can be displayed and recorded in real time through the display screen 19, which is convenient for the experimenters to observe and understand the experimental dynamics. At the same time, the experimental data can also be exported through Bluetooth.

[0050] Through the above-designed structure, when clamping the rat's tail for experiment, the compression of the rat's tail artery can be reduced, and at the same time, the stress response of the experimental rat due to compression can be effectively avoided, which leads to inaccurate experimental data. At the same time, the sphygmomanometer body 1 designed in this application uses the combined sound and light technology to significantly improve the measurement accuracy of the rat's tail artery blood pressure and related parameters, reducing the measurement error.

[0051] The movable clamping plate 12 is provided with a sliding mechanism 20, which includes a through slot 21 on the movable clamping plate 12, a moving block 22 is slidably connected in the through slot 21, two support arms 23 are fixedly installed on the moving block 22, and the miniature high-frequency ultrasonic probe 18 is rotatably connected to the two support arms 23. A boss 24 is fixedly installed on one side of the moving block 22, a limit rod 26 is slidably connected in the boss 24, a fixed disk 25 is fixedly installed on one end of the limit rod 26, and a spring is fixedly installed between the fixed disk 25 and the boss 24, a plurality of through holes 27 are opened on one side of the movable clamping plate 12, and a limit slot 28 is opened on one side of the moving block 22.

[0052] Specifically, the limiting rod 26 is provided with a positioning mechanism 30, which includes two positioning rods 31 fixedly connected to the limiting rod 26, and one side of the boss 24 is provided with a positioning groove 32 adapted to the positioning rod 31. A plurality of elastic balls 40 are fixedly installed on one side of the support arm 23, and the elastic balls 40 are located between the support arm 23 and the miniature high-frequency ultrasonic probe 18. A hollow collar 80 is fixedly sleeved on the surface of the limiting rod 26, and a connecting tube 50 connected to the inside of the collar 80 is fixedly installed at one end of the fixing plate 25, and one end of the connecting tube 50 is connected to the plurality of elastic balls 40.

[0053] During operation, when the moving clamping plate 12 and the static clamping plate 11 clamp the mouse tail, the moving block 22 in the sliding through slot 21 is moved with the micro high-frequency ultrasonic probe 18, so that the micro high-frequency ultrasonic probe 18 can find a suitable position for detection. When the moving block 22 is sliding, the fixed plate 25 is pulled, and the fixed plate 25 is used to bring the limiting rod 26 out of the limiting slot 28 and the through hole 27, and the positioning rod 31 on the limiting rod 26 is inserted into the positioning slot 32 of the boss 24 for temporary fixation, so that the limiting rod 26 will not be reset when the moving block 22 moves and affect the sliding.

[0054] When the miniature high-frequency ultrasonic probe 18 moves to a suitable position, the limiting rod 26 on the boss 24 is loosened, so that the limiting rod 26 passes through the through hole 27 and enters the limiting groove 28 of the moving block 22 to be fixed, thereby locking the position that the miniature high-frequency ultrasonic probe 18 needs to detect. When the limiting rod 26 slides toward the through hole 27, it will slide with the collar 80 on the surface, and when the limiting rod 26 enters the through hole 27 with the collar 80, the through hole 27 will continuously squeeze the collar 80 on the surface of the limiting rod 26, and the collar 80 will be deformed after being squeezed, and the gas inside it will enter the plurality of elastic balls 40 through the connecting pipe 50, so that the elastic balls 40 will expand rapidly and abut against the miniature high-frequency ultrasonic probe 18, thereby increasing the friction between the miniature high-frequency ultrasonic probe 18 and making it unable to rotate easily. At this time, the miniature high-frequency ultrasonic probe 18 is rotated again, so that the miniature high-frequency ultrasonic probe 18 can be rotated finely and accurately adjusted, so that the miniature high-frequency ultrasonic probe 18 can be adjusted to a suitable position for use. It should be noted that when the dynamic clamping plate 12 and the static clamping plate 11 clamp the rat's tail, the inner walls of the dynamic clamping plate 12 and the static clamping plate 11 are in close contact with the rat's tail. At this time, the end of the miniature high-frequency ultrasonic probe 18 will also be in close contact with the surface of the rat's tail, thereby facilitating the monitoring of the rat's tail.

[0055] The above-designed sliding mechanism 20, positioning mechanism 30 and collar 80 can realize fast fixing of the miniature high-frequency ultrasonic probe 18 and fine-tuning of its rotation. The structure is simple and easy to operate, and the rat coccygeal artery can be monitored more accurately.

[0056] A blowing mechanism 60 is arranged in the limiting groove 28, and the blowing mechanism 60 includes a hollow elastic block 61 fixedly installed in the storage groove 71, and an air guide pipe 62 connected to the interior is fixedly installed on one side of the elastic block 61, and an air outlet pipe 63 is fixedly installed on one side of the support arm 23, and the air outlet pipe 63 is connected to the interior of the air guide pipe 62.

[0057] Specifically, the extension assembly 64 includes a slide groove 641 provided in the air outlet pipe 63, a slider 642 is slidably connected in the slide groove 641 through an elastic rope 643, a hollow slide tube 644 is fixedly installed at one end of the slider 642, and two symmetrically arranged end caps 645 are rotatably connected in the slide tube 644 through a torsion spring. The fixing assembly 65 includes an arc-shaped fixing rod 651 fixedly installed on one side of the end cap 645, the fixing rod 651 is made of rubber, and the fixing rod 651 gradually enlarges from the end close to the end cap 645 to the end away from the end cap 645, and a fixing groove 652 adapted to the fixing rod 651 is provided inside the slide tube 644.

[0058] During operation, the limiting rod 26 will squeeze the elastic block 61 when entering the limiting groove 28, so that the gas in the elastic block 61 enters the outlet pipe 63 through the connecting pipe 50. The gas in the outlet pipe 63 will push the slide pipe 644 to slide toward the micro-high-frequency ultrasonic probe 18. When the slider 642 that drives the slide pipe 644 to move slides to the maximum in the slide groove 641 and cannot move anymore, the end of the slide pipe 644 is close to the micro-high-frequency ultrasonic probe 18, and the gas in the elastic block 61 is still continuously filled into the outlet pipe 63, and then rotates to push open the end cover 645 in the slide pipe 644, so that the end cover 645 rotates into the slide pipe 644 with the fixing rod 651, and the fixing rod 651 made of rubber rotates and inserts into the fixing groove 652, thereby temporarily fixing the end cover 645. At this time, the gas in the outlet pipe 63 is quickly blown toward the micro-high-frequency ultrasonic probe 18 through the slide pipe 644, so as to achieve rapid blowing and cleaning of the micro-high-frequency ultrasonic probe 18. Since the slide tube 644 slides out and approaches the micro-high frequency ultrasonic probe 18, the gas can be blown more accurately to the micro-high frequency ultrasonic probe 18, achieving an efficient and accurate cleaning effect. When the slide tube 644 no longer emits gas, the elastic rope 643 brings the slider 642 and the slide tube 644 back to their original positions, and the slide tube 644 shrinks into the outlet pipe 63, thereby not affecting the normal operation of the micro-high frequency ultrasonic probe 18. It should be noted that the designed fixing assembly 65 will not immediately bring the end cap 645 back to its original position after the slide tube 644 is reset to the outlet pipe 63, but after the experiment is over, the limit rod 26 is separated from the limit groove 28 and no longer squeezes the elastic block 61 (the rat tail artery experiment time is short, so the limit rod 26 only squeezes the elastic frame briefly), and the end cap 645 is slowly driven to reset under the action of the torsion spring, thereby facilitating the gas to inflate the elastic block 61 through the slide tube 644, the outlet pipe 63 and the connecting pipe 50.

[0059] The designed air blowing mechanism 60 can efficiently and quickly clean the micro high-frequency ultrasonic probe 18, effectively remove dust and impurities on the surface of the micro high-frequency ultrasonic probe 18, ensure that the probe surface is clean and smooth, and help maintain the clarity and accuracy of ultrasonic imaging. At the same time, air blowing cleaning helps to remove surface particles, prevent wear of the micro high-frequency ultrasonic probe 18, and thus increase the service life of the micro high-frequency ultrasonic probe 18.

[0060] A disinfection mechanism 70 is arranged in the movable splint 12, and the disinfection mechanism 70 includes a storage groove 71 opened in the movable splint 12, a rubber disinfection box 72 is installed in the storage groove 71, a plurality of hollow roll films 74 connected to the interior and with a one-way valve are fixedly installed on one side of the disinfection box 72, a liquid inlet pipe connected to the interior and with a one-way valve is installed on one side of the disinfection box 72, a plurality of storage holes 73 are opened on one side of the movable splint 12, the hollow roll film 74 is in the storage frame, and a pressure plate 75 is arranged on one side of the moving block 22.

[0061] Specifically, two fixed plates 76 are fixedly installed on one side of the moving block 22, and the two ends of the pressing plate 75 are fixedly connected to the two pressing plates 75 respectively, and the pressing plate 75 is in an arc shape. A liquid outlet component 77 is provided on the hollow roll film 74, and the liquid outlet component 77 includes a plurality of through holes 771 opened on the hollow roll film 74, and a flexible cloth 772 is fixedly installed in the through holes 771. The surface of the flexible cloth 772 is provided with a plurality of liquid outlet holes 773 connected to the inside of the hollow roll film 74, and the end of the hollow roll film 74 away from the disinfection box 72 is in a closed state.

[0062] During operation, when the experiment is over, the moving clamp 12 and the static clamp 11 no longer clamp the mouse tail, and the sliding block 22 is reset, and the moving block 22 is used to drive the pressing plate 75 and the fixed plate 76 to slide excessively toward the storage groove 71, so that the pressing plate 75 squeezes the rubber disinfection box 72, and the disinfection box 72 in the disinfection box 72 is quickly filled into the hollow roll film 74, so that the hollow roll film 74 expands and stretches. It should be noted that when the hollow roll film 74 is rolled up, the flexible cloth 772 is in a stacked state, so the liquid outlet 773 will not leak, which facilitates the disinfectant to quickly fill the hollow roll film 74, so that it expands and stretches. As the hollow film roll 74 is stretched, the flexible cloth 772 is in a tight state, and the liquid outlet holes 773 are fully opened. At this time, the disinfectant in the hollow film roll 74 will be sprayed out through the plurality of liquid outlet holes 773 on the plurality of flexible cloths 772, thereby quickly disinfecting the movable clamping plate 12 and the static clamping plate 11, so as to facilitate the next experiment. The designed fixing plate 76 can prevent the pressing plate 75 from completely squeezing the disinfection box 72, causing the disinfection box 72 to be broken after being over-squeezed.

[0063] Working principle: When conducting experiments on the rat's tail, first apply a small amount of coupling agent to the rat's tail, and use the micro electric push rod 14 to drive the moving splint 12 to move, so that one side of the moving splint 12 fits with the rat's tail. At this time, the static splint 11 and the moving splint 12 fit with the rat's tail. At this time, the pressure sensor 15 can transmit the monitored pressure to the display screen 19 for recording in real time. The static splint 11 and the moving splint 12 made of flexible silicone material can gently fix the rat's tail artery to avoid blood flow interference caused by traditional cuff-type pressurization. The micro high-frequency ultrasonic probe 18, the light source detector 16 and the dual-wavelength light source detection instrument 17 are used to measure the vascular wall thickness, vascular diameter and blood flow velocity. The photoelectric volumetric sensor monitors the pulse waveform and vascular volume changes to ensure stable collection of vascular anatomy and dynamic signals.

[0064] When the moving clamp 12 and the static clamp 11 clamp the mouse tail, the moving block 22 in the sliding slot 21 is moved with the miniature high-frequency ultrasonic probe 18, so that the miniature high-frequency ultrasonic probe 18 can find a suitable position for detection. When the moving block 22 is sliding, the fixed plate 25 is pulled, and the fixed plate 25 is used to bring the limiting rod 26 out of the limiting groove 28 and the through hole 27, and the positioning rod 31 on the limiting rod 26 is inserted into the positioning groove 32 of the boss 24 for temporary fixation. When the miniature high-frequency ultrasonic probe 18 moves to a suitable position, the limiting rod 26 on the boss 24 is released, so that the limiting rod 26 passes through the through hole 27 and enters the limiting groove 28 of the moving block 22 for fixation, thereby locking the position that the miniature high-frequency ultrasonic probe 18 needs to detect. When the limiting rod 26 slides toward the through hole 27, it will slide with the collar 80 on the surface, and when the limiting rod 26 enters the through hole 27 with the collar 80, the through hole 27 will continuously squeeze the collar 80 on the surface of the limiting rod 26, and the collar 80 will be deformed after being squeezed, and the gas inside it will enter the plurality of elastic balls 40 through the connecting tube 50, so that the elastic balls 40 will expand rapidly and abut against the miniature high-frequency ultrasonic probe 18, thereby increasing the friction between the miniature high-frequency ultrasonic probe 18 and the miniature high-frequency ultrasonic probe 18, so that it cannot be easily rotated. At this time, the miniature high-frequency ultrasonic probe 18 is rotated again, so that the miniature high-frequency ultrasonic probe 18 can be rotated finely and accurately adjusted, so that the miniature high-frequency ultrasonic probe 18 can be adjusted to a suitable position for use. It should be noted that when the moving clamp 12 and the static clamp 11 clamp the rat tail, the inner wall of the moving clamp 12 and the static clamp 11 is in close contact with the rat tail, and the end of the miniature high-frequency ultrasonic probe 18 is also in close contact with the surface of the rat tail, so as to facilitate the monitoring of the rat tail.

[0065] When the limiting rod 26 enters the limiting groove 28, it will squeeze the elastic block 61, so that the gas in the elastic block 61 enters the air outlet pipe 63 through the connecting pipe 50. The gas in the air outlet pipe 63 will push the slide pipe 644 to slide toward the micro-high-frequency ultrasonic probe 18. When the slider 642 that drives the slide pipe 644 to move slides to the maximum in the slide groove 641 and cannot move anymore, the end of the slide pipe 644 is close to the micro-high-frequency ultrasonic probe 18, and the gas in the elastic block 61 is still continuously filled into the air outlet pipe 63, and then rotates to push open the end cover 645 in the slide pipe 644, so that the end cover 645 rotates into the slide pipe 644 with the fixing rod 651, and the fixing rod 651 made of rubber rotates and inserts into the fixing groove 652, thereby temporarily fixing the end cover 645. At this time, the gas in the air outlet pipe 63 is quickly blown toward the micro-high-frequency ultrasonic probe 18 through the slide pipe 644, so as to achieve rapid blowing and cleaning of the micro-high-frequency ultrasonic probe 18. Since the slide tube 644 slides out close to the micro-high frequency ultrasonic probe 18, the gas can be blown more accurately to the micro-high frequency ultrasonic probe 18, achieving an efficient and accurate cleaning effect. When the slide tube 644 no longer discharges gas, the elastic rope 643 brings the slider 642 and the slide tube 644 back to their original position, and the slide tube 644 shrinks into the outlet pipe 63, thereby not affecting the normal operation of the micro-high frequency ultrasonic probe 18. It should be noted that the designed fixing component 65 will not immediately bring the end cover 645 back to its original position after the slide tube 644 is reset to the outlet pipe 63. Instead, after the experiment is over, the limit rod 26 is separated from the limit groove 28 and no longer squeezes the elastic block 61, and the end cover 645 is slowly driven to reset under the action of the torsion spring, thereby facilitating the gas to inflate the elastic block 61 through the slide tube 644, the outlet pipe 63 and the connecting pipe 50.

[0066] When the experiment is over, the moving clamp 12 and the static clamp 11 no longer clamp the mouse tail. At this time, the sliding moving block 22 is reset, and the moving block 22 is used to drive the pressing plate 75 and the fixed plate 76 to slide excessively toward the storage groove 71, so that the pressing plate 75 squeezes the rubber material disinfection box 72, and the disinfection box 72 in the disinfection box 72 is quickly filled into the hollow roll film 74, so that the hollow roll film 74 expands and stretches. It should be noted that when the hollow roll film 74 is rolled up, the flexible cloth 772 is in a stacked state, so the liquid outlet 773 will not leak, which facilitates the disinfectant to quickly fill the hollow roll film 74, so that it expands and stretches. As the hollow roll film 74 stretches, the flexible cloth 772 is in a tight state, and then the liquid outlet 773 is fully opened. At this time, the disinfectant in the hollow roll film 74 will spray out through the several liquid outlet holes 773 on the several flexible cloths 772, and then quickly disinfect the moving clamp 12 and the static clamp 11, so as to facilitate the next experiment to continue using.

[0067] The above-mentioned front, back, left, right, top and bottom are all based on the figures in the specification. Figure 1As a benchmark, according to the person's observation perspective, the side of the device facing the observer is defined as the front, the left side of the observer is defined as the left, and so on.

[0068] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the scope of protection of the present invention.

[0069] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A non-invasive sphygmomanometer for rats, characterized in that: The sphygmomanometer comprises a body (1), the body (1) being provided with a detection mechanism (10), the detection mechanism (10) comprising a static clamping plate (11) fixedly mounted on the bottom of the body (1), the bottom of the body (1) being provided with a groove (13) for mounting a micro electric push rod (14), the output end of the micro electric push rod (14) being fixedly mounted with a dynamic clamping plate (12), the surfaces of the static clamping plate (11) and the dynamic clamping plate (12) being close to each other being made of a flexible silicone material, the static clamping plate (11) and the dynamic clamping plate (12) being mounted with photoplethysmography sensors, and the body (1) being provided with a built-in Bluetooth module; Four pressure sensors (15) are fixedly mounted on the sides of the static clamping plate (11) and the dynamic clamping plate (12) close to each other. The four pressure sensors (15) are mounted in groups of two on the static clamping plate (11) and the dynamic clamping plate (12). Light source detectors (16) are mounted on the static clamping plate (11) and the dynamic clamping plate (12) respectively. A dual-wavelength light source detection instrument (17) is fixedly mounted on one side of the dynamic clamping plate (12). A miniature high-frequency ultrasonic probe (18) is mounted on the dynamic clamping plate (12). A display screen (19) is provided on the sphygmomanometer body (1).

2. The non-invasive sphygmomanometer for rats according to claim 1, characterized in that: The movable clamping plate (12) is provided with a sliding mechanism (20), the sliding mechanism (20) comprises a through slot (21) provided on the movable clamping plate (12), a moving block (22) is slidably connected in the through slot (21), two supporting arms (23) are fixedly mounted on the moving block (22), and the miniature high-frequency ultrasonic probe (18) is rotatably connected to the two supporting arms (23); A boss (24) is fixedly mounted on one side of the moving block (22), a limiting rod (26) is slidably connected inside the boss (24), a fixed disk (25) is fixedly mounted on one end of the limiting rod (26), a spring is fixedly mounted between the fixed disk (25) and the boss (24), a plurality of through holes (27) are provided on one side of the moving clamp (12), and a limiting groove (28) is provided on one side of the moving block (22).

3. The non-invasive sphygmomanometer for rats according to claim 2, characterized in that: The limiting rod (26) is provided with a positioning mechanism (30), the positioning mechanism (30) comprising two positioning rods (31) fixedly connected to the limiting rod (26), and one side of the boss (24) is provided with a positioning groove (32) matched with the positioning rod (31).

4. The non-invasive sphygmomanometer for rats according to claim 2, characterized in that: A plurality of elastic balls (40) are fixedly mounted on one side of the support arm (23), the elastic balls (40) are located between the support arm (23) and the miniature high-frequency ultrasonic probe (18), a hollow collar (80) is fixedly sleeved on the surface of the limit rod (26), a connecting tube (50) connected to the inside of the collar (80) is fixedly mounted on one end of the fixed plate (25), and one end of the connecting tube (50) is connected to the plurality of elastic balls (40).

5. The non-invasive sphygmomanometer for rats according to claim 2, characterized in that: An air blowing mechanism (60) is arranged in the limiting groove (28), and the air blowing mechanism (60) comprises a hollow elastic block (61) fixedly mounted in the storage groove (71), an air guide pipe (62) connected to the interior is fixedly mounted on one side of the elastic block (61), and an air outlet pipe (63) is fixedly mounted on one side of the support arm (23), and the air outlet pipe (63) is connected to the interior of the air guide pipe (62); An extension component (64) is arranged inside the air outlet pipe (63).

6. The non-invasive sphygmomanometer for rats according to claim 5, characterized in that: The extension component (64) comprises a slide groove (641) provided in the air outlet pipe (63), a slider (642) being slidably connected in the slide groove (641) via an elastic rope (643), a hollow slide tube (644) being fixedly mounted at one end of the slider (642), and two symmetrically arranged end covers (645) being rotatably connected in the slide tube (644) via a torsion spring; A fixing assembly (65) is arranged inside the sliding tube (644).

7. The non-invasive sphygmomanometer for rats according to claim 6, characterized in that: The fixing assembly (65) comprises an arc-shaped fixing rod (651) fixedly mounted on one side of the end cover (645); the fixing rod (651) is made of rubber material; the fixing rod (651) gradually enlarges from one end close to the end cover (645) to one end away from the end cover (645); and a fixing groove (652) adapted to the fixing rod (651) is provided inside the sliding tube (644).

8. The non-invasive sphygmomanometer for rats according to claim 2, characterized in that: A disinfection mechanism (70) is arranged in the movable clamping plate (12), and the disinfection mechanism (70) includes a storage groove (71) provided in the movable clamping plate (12), a rubber disinfection box (72) is installed in the storage groove (71), a plurality of hollow roll films (74) connected to the interior and provided with a one-way valve are fixedly installed on one side of the disinfection box (72), a liquid inlet pipe connected to the interior and provided with a one-way valve is installed on one side of the disinfection box (72), a plurality of storage holes (73) are opened on one side of the movable clamping plate (12), the hollow roll film (74) is in the storage frame, and a pressure plate (75) is arranged on one side of the movable block (22).

9. The non-invasive sphygmomanometer for rats according to claim 8, characterized in that: Two fixed plates (76) are fixedly mounted on one side of the moving block (22), and both ends of the pressing plate (75) are respectively fixedly connected to the two pressing plates (75), and the pressing plate (75) is in an arc shape.

10. The non-invasive sphygmomanometer for rats according to claim 8, characterized in that: The hollow membrane roll (74) is provided with a liquid outlet component (77), and the liquid outlet component (77) includes a plurality of through holes (771) opened on the hollow membrane roll (74), a flexible cloth (772) is fixedly installed in the through holes (771), and a plurality of liquid outlet holes (773) connected to the inside of the hollow membrane roll (74) are opened on the surface of the flexible cloth (772), and the end of the hollow membrane roll (74) away from the disinfection box (72) is in a closed state.

Images