Traditional Chinese medicine for treating Kaschin-Beck disease and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof, the preparation method comprises the following steps: preparing the following raw materials: prepared rehmannia root, Chinese angelica, wolfberry, parasitic loranthus, eucommia ulmoides, achyranthes bidentata, astragalus membranaceus, pseudo-ginseng, rhizoma drynariae, rheum officinale, kadsura pepper stem, rhizoma anemarrhenae and amber; the raw materials in the step S1 are completely purchased, the good quality of the traditional Chinese medicinal materials is ensured, and cleaning is conducted. Hard medicinal materials such as rheum officinale, pseudo-ginseng and amber can be soaked in water to be soft, effective components of the medicinal materials can be conveniently extracted, and meanwhile the medicinal materials need to be cut or smashed. The design of the prescription is based on the pathological characteristics of Kaschin-Beck disease, the compatibility of traditional Chinese medicines capable of nourishing liver and kidney, promoting blood circulation to remove blood stasis and strengthening tendons and bones is comprehensively utilized, and the effects of improving joint functions and promoting bone repair are achieved by adjusting bone metabolism of the body and relieving joint symptoms. Through conditioning of the traditional Chinese medicines, the bone health of a patient is expected to be fundamentally improved, the symptom of the Kaschin-Beck disease is relieved, and a relatively safe and effective treatment choice is provided.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine preparation, in particular to a Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof. Background Art

[0002] Kaschin-Beck disease is an endemic, deforming bone and joint disease that occurs in children and adolescents. Its primary lesions are mainly multiple symmetrical degeneration and necrosis of epiphyseal cartilage, epiphyseal cartilage and articular cartilage during bone development, as well as secondary degenerative bone and joint disease; clinical manifestations include pain, thickening, deformation, limited movement, muscle atrophy in the joints of the limbs, and in severe cases, short fingers, short limbs, and even dwarfism.

[0003] Kaschin-Beck disease is an endemic disease that seriously damages children's articular cartilage, leading to cartilage development disorders, joint deformities, and then osteoarthritis. The disease mostly occurs in school age. After the onset of the disease, the joints gradually thicken and become deformed, resulting in developmental disorders and short stature. In severe cases, it leads to disability and loss of ability to work. The disease was once prevalent in the Russian Far East, northern North Korea, and northern Japan, but is now rarely reported abroad. By the end of 2023, Kaschin-Beck disease was mainly distributed in 379 counties in 14 provinces, municipalities, and autonomous regions in my country, with 164,000 active patients;

[0004] The etiology of Kashin-Beck disease has been studied for more than 170 years, and a variety of environmental etiology theories have been proposed. The main theories are currently focused on the low-selenium theory, the food fungal toxin - T-2 toxin poisoning theory, and the T-2 toxin poisoning theory in a low-selenium environment. The environmental biological low-selenium theory believes that environmental selenium deficiency is related to the onset of Kashin-Beck disease; the water, soil, and grain in the areas affected by Kashin-Beck disease are all low in selenium, which leads to a low-selenium nutritional state in the people in the affected areas through the food chain. The selenium content in the bodies of children with the disease is even lower, which affects the function of selenoproteins or selenoenzymes, leading to the occurrence of Kashin-Beck disease;

[0005] After years of comprehensive prevention and control measures such as water improvement, food replacement, and selenium supplementation, my country has basically eliminated Kaschin-Beck disease. More than 95% of the disease-affected counties in the country have achieved the elimination target, including all disease-affected counties in nine provinces, including Hebei, Shanxi, Liaoning, Jilin, Heilongjiang, Shandong, Henan, Sichuan, and Shaanxi. The action goal of the "National Action Plan for Consolidation and Improvement of Endemic Disease Prevention and Control (2023-2025)" is to eliminate the harm of Kaschin-Beck disease by the end of 2025. All disease-affected counties in the country have achieved elimination from basic elimination;

[0006] The pathogenesis of KBD has evolved from suspected environmental factors, population, individual, organ, and tissue cell levels to chondrocyte differentiation regulatory factors and their related genes. Early studies have shown that KBD not only causes cartilage damage but is also accompanied by damage to the myocardium, bone marrow, skeletal muscle, vascular wall, stomach, endocrine glands, and peripheral nerves, and manifests as endogenous sulfur metabolism disorders, cartilage metabolism, lipid peroxidation, and selenium metabolism disorders. In the mid-20th century, Professor Mo Dongxu and others conducted systematic pathological studies and determined that KBD mainly invades the deep chondrocytes of the epiphyseal cartilage, epiphyseal cartilage, and articular cartilage of the developing endochondral ossification type of bones in children, followed by endochondral ossification disorders and deforming joint disease;

[0007] In the mid-20th century, my country found that the DNA content of cartilage in children with KBD was reduced, and plasma proteins and amino acids were abnormal. In recent years, gene chips and surface-enhanced laser desorption / ionization time-of-flight mass spectrometry proteomics chip technology have been used to find that the gene expression profile of cartilage cells and the protein expression profile of blood in patients with KBD are different from those in healthy people in diseased and non-disease areas, as well as other bone and joint diseases such as osteoarthritis.

[0008] The basis of KBD is the primary necrosis of articular chondrocytes and secondary osteoarthritis. Since it mainly occurs in the growth and development stage of children's bones, most patients can recover completely by blocking the cause and appropriate treatment in the early stage of the disease. Once the disease is not controlled in time, it will further develop into typical clinical signs of osteoarthritis such as destruction, proliferation, remodeling, and deformation of bone tissue. At the same time, bones and joints will undergo degenerative changes with aging, so that KBD will eventually develop into a bone and joint disease that is essentially the same as senile osteoarthritis and bone hyperplasia. Therefore, the prevention and treatment of KBD should focus on blocking the transmission route of the cause, controlling new cases, and proactive primary prevention. At the same time, attention should be paid to early detection, early intervention, and early treatment of children's cases to enable them to recover or avoid further development of KBD; attention should be paid to the clinical treatment of adult patients so that they can restore some of their mobility and labor capabilities and improve their quality of life;

[0009] In the existing technology, although the treatment of KBD can relieve symptoms and improve the quality of life of patients, there are still some shortcomings and challenges:

[0010] Delayed diagnosis: The symptoms of KBD are often subtle and similar to other bone and joint diseases, making them easy to be misdiagnosed or ignored. Patients may not be diagnosed until their condition is more serious, resulting in delayed treatment.

[0011] Limited treatment effects: Current treatments mainly rely on calcium supplements, vitamin D, nonsteroidal anti-inflammatory drugs (NSAIDs) and other drugs, as well as physical therapy and moderate exercise. However, these treatments can only relieve symptoms, but cannot cure the root cause or completely prevent further damage to bones and joints.

[0012] Dependence on long-term drug treatment: Since KBD is often accompanied by calcium-phosphorus metabolism disorders, patients need to take calcium and vitamin D supplements for a long time, but long-term dependence on drugs may cause side effects and have limited effects on some patients.

[0013] Local calcification cannot be reversed: For calcium salt deposition and joint calcification that have already occurred, existing treatments cannot completely reverse the damage, and calcified soft tissue or joint deformities may cause long-term functional impairment.

[0014] Insufficient individualized treatment: The cause and pathological mechanism of KBD may vary from person to person, but current treatment plans are usually relatively uniform and lack individualized treatment methods for different patients.

[0015] Lack of effective intervention techniques: Some studies have shown that physical therapy, joint orthotics and other methods can be helpful, but there is no completely effective intervention technique that can prevent the progression of the disease in the early stages.

[0016] Incomplete disease prevention measures: There is still a lack of targeted public health intervention measures for the prevention of KBD. Especially for children and adolescents, how to effectively prevent the occurrence of vitamin D or calcium deficiency and how to adjust diet and lifestyle are still challenges.

[0017] In general, existing treatments are helpful in alleviating symptoms and improving quality of life, but there are still major shortcomings in curing the causes, reversing pathological changes, and improving the level of individualized treatment.

[0018] For this reason, we propose a traditional Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof. Summary of the invention

[0019] To achieve the above object, the present invention provides the following technical solution: a Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof, comprising the following steps:

[0020] S1: Prepare raw materials: the raw materials include: Radix Rehmanniae Preparata, Angelica Sinensis, Fructus Lycii, Herba Mori, Eucommia Bark, Achyranthes Bidentatae, Radix Astragali, Radix Notoginseng, Rhizoma Drynariae, Radix Rhei, Caulis Piperis, Rhizoma Anemarrhenae and Amber;

[0021] S2: Preparing medicinal materials: Purchase all the raw materials in step S1, ensure the quality of the Chinese medicinal materials, and wash them. For hard medicinal materials such as rhubarb, Panax notoginseng, amber, etc., they can be softened with water first to facilitate the extraction of their effective ingredients. At the same time, the medicinal materials should be cut or crushed to facilitate decoction and release of medicinal effects;

[0022] S3: Decoction of medicinal materials: first mix all the medicinal materials, put them into a medicine pot, add clean water, the water volume is controlled to 500-600 ml, soak the medicinal materials for 30 minutes before decoction, boil the medicinal materials over high heat first, after the medicinal liquid boils, turn to low heat and slowly decoct for 40-60 minutes, filter out the decoction, add 300 ml of water again, decoct for 30 minutes, filter again, mix the decoctions after two decoctions, and after merging, take about 500 ml as one dose per day;

[0023] S4: Dosage: Daily use: Patients should take it twice a day, morning and evening, 250 ml each time. It is best to take it one hour after a meal to reduce gastrointestinal irritation. Treatment course: It is recommended to take it for 4-6 weeks as a course of treatment. After the symptoms are alleviated, the dosage can be appropriately reduced and continued for 2-3 weeks to consolidate the therapeutic effect;

[0024] S5: Precautions for use: During the period of taking this prescription, you should pay attention to a reasonable diet and avoid excessive intake of high-salt and high-fat foods. Patients should avoid strenuous exercise during the medication period and appropriately increase low-intensity exercise, such as walking, swimming, etc., to avoid excessive burden on the joints.

[0025] Preferably, the specific amounts of raw materials in step S1 are: 15g of Rehmannia root, 12g of Angelica sinensis, 10g of Lycium barbarum, 12g of Taxillus parasiticus, 10g of Eucommia ulmoides, 12g of Achyranthes bidentata, 15g of Astragalus, 6g of Panax notoginseng, 15g of Drynaria fortunei, 6g of Rhubarb, 15g of Piper mesenteriae serrata, 10g of Anemarrhena asphodeloides and 3g of Amber.

[0026] Preferably, in step S1, some medicinal materials (such as parasitic plants, wolfberries, etc.) need to be cleaned, but avoid scrubbing vigorously to avoid losing the active ingredients. After washing with clean water, use a clean towel or paper towel to absorb the water. Hard medicinal materials: such as amber, rhubarb, bone drynaria, etc., can be cut with a knife or crushed with a medicinal material crusher. The crushed medicinal materials help to release the active ingredients quickly. Soft medicinal materials: such as wolfberries, angelica, etc. do not need to be cut and can be used directly. According to the weight requirements of each medicinal material, the medicinal materials are packaged and marked clearly to avoid confusion. If there are many medicinal materials, it is recommended to record their weight one by one.

[0027] Preferably, in step S2, the decocting utensils are prepared: medicine pot: use a wide-mouthed deep pot, preferably a casserole or a stainless steel pot, so that the medicine liquid can be heated evenly, gauze bag: if there are substances with larger particles in the medicinal materials, such as amber, etc., they can be wrapped in a gauze bag to prevent the medicinal materials from scattering during the decoction process, filter: used to filter the medicinal liquid to prevent the dregs from entering the liquid for consumption, add water: after all the medicinal materials are placed in the medicine pot, add 500-600 ml of water (the amount of water is adjusted according to the size of the pot and the amount of medicinal materials) to ensure that the medicinal materials are completely soaked. Cold soaking with clean water for 30 minutes is conducive to the initial softening of the medicinal materials and the release of the active ingredients.

[0028] Preferably, the decoction process in step S3 is as follows: first decoction: boil the medicinal liquid with a high fire, turn to a low fire after the water boils, keep the water surface slightly open, and decoct for about 40-60 minutes. The pot lid can be covered, but a small gap should be left to prevent the medicinal liquid from overflowing. Second decoction: after the first decoction is completed, filter out the medicinal liquid. Then add about 300 ml of clean water, decoct again, adjust the firepower to medium and small fire, and the decoction time is 30 minutes. Filter: the medicinal liquid after the two decoctions is mixed, and the medicinal residue is filtered using gauze or a filter. Keep the medicinal liquid clear for drinking.

[0029] Preferably, the daily dosage in step S4 is: 250 ml of the medicine solution is taken each time, twice a day, morning and evening. The medicine solution is preferably taken within 1 hour after a meal to reduce irritation to the gastrointestinal tract. Taking temperature: the medicine solution should be taken warm, avoid overheating or overcooling, and the temperature between 40-50°C is more suitable. Overheated medicine solution may destroy some effective ingredients, and overcooling may cause gastrointestinal discomfort. Keep taking it: In order to obtain the best effect, it is recommended that patients continue to take it for 4-6 weeks. After the course of treatment, if the symptoms are relieved, the dosage can be reduced appropriately, and it should be continued for 2-3 weeks to consolidate the therapeutic effect, and diet and lifestyle adjustments should be made: During drug treatment, patients are advised to pay attention to calcium and vitamin D supplementation, avoid excessive fatigue, exercise moderately, and maintain healthy eating habits.

[0030] Preferably, during the treatment in step S5, the patient should avoid consuming spicy and irritating foods, greasy foods, and excessive caffeine, etc., so as not to affect the efficacy of the medicine. It is recommended that the patient have regular follow-up during the use of the prescription, especially for joint changes in KBD. If there is discomfort or worsening of symptoms, the treatment plan should be adjusted in time. While taking Chinese medicine, some physical therapy methods can be considered, such as hot compresses, massage, traction, etc., to relieve joint pain and stiffness.

[0031] Compared with the prior art, the present invention provides a traditional Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof, which has the following beneficial effects:

[0032] The Chinese medicine for treating Kashin-Beck disease and its preparation method are designed based on the pathological characteristics of Kashin-Beck disease, and comprehensively utilize the compatibility of Chinese medicines that nourish the liver and kidneys, promote blood circulation and remove blood stasis, and strengthen tendons and bones. It aims to improve joint function and promote bone repair by regulating the body's bone metabolism and relieving joint symptoms. Through the conditioning of Chinese medicine, it is expected to fundamentally improve the patient's bone health, alleviate the symptoms of Kashin-Beck disease, and provide a relatively safe and effective treatment option. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Example

[0035] A Chinese medicine for treating Kaschin-Beck disease and an embodiment of its preparation method

[0036] A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof, comprising the following steps:

[0037] S1: Prepare raw materials: the raw materials include: Radix Rehmanniae Preparata, Angelica Sinensis, Fructus Lycii, Herba Mori, Eucommia Bark, Achyranthes Bidentatae, Radix Astragali, Radix Notoginseng, Rhizoma Drynariae, Radix Rhei, Caulis Piperis, Rhizoma Anemarrhenae and Amber;

[0038] S2: Preparing medicinal materials: Purchase all the raw materials in step S1, ensure the quality of the Chinese medicinal materials, and wash them. For hard medicinal materials such as rhubarb, Panax notoginseng, amber, etc., they can be softened with water first to facilitate the extraction of their effective ingredients. At the same time, the medicinal materials should be cut or crushed to facilitate decoction and release of medicinal effects;

[0039] S3: Decoction of medicinal materials: first mix all the medicinal materials, put them into a medicine pot, add clean water, the water volume is controlled to 500-600 ml, soak the medicinal materials for 30 minutes before decoction, boil the medicinal materials over high heat first, after the medicinal liquid boils, turn to low heat and slowly decoct for 40-60 minutes, filter out the decoction, add 300 ml of water again, decoct for 30 minutes, filter again, mix the decoctions after two decoctions, and after merging, take about 500 ml as one dose per day;

[0040] S4: Dosage: Daily use: Patients should take it twice a day, morning and evening, 250 ml each time. It is best to take it one hour after a meal to reduce gastrointestinal irritation. Treatment course: It is recommended to take it for 4-6 weeks as a course of treatment. After the symptoms are alleviated, the dosage can be appropriately reduced and continued for 2-3 weeks to consolidate the therapeutic effect;

[0041] S5: Precautions for use: During the period of taking this prescription, you should pay attention to a reasonable diet and avoid excessive intake of high-salt and high-fat foods. Patients should avoid strenuous exercise during the medication period and appropriately increase low-intensity exercise, such as walking, swimming, etc., to avoid excessive burden on the joints.

[0042] Specifically, the specific amounts of raw materials in step S1 are: 15g of Rehmannia root, 12g of Angelica sinensis, 10g of Lycium barbarum, 12g of Viscum album, 10g of Eucommia ulmoides, 12g of Achyranthes bidentata, 15g of Astragalus membranaceus, 6g of Panax notoginseng, 15g of Drynaria fortunei, 6g of Rhubarb, 15g of Piper mesenteriae, 10g of Anemarrhena asphodeloides and 3g of Amber.

[0043] Specifically, in step S1, some medicinal materials (such as mistletoe, wolfberry, etc.) need to be cleaned, but avoid scrubbing hard to avoid losing the active ingredients. After washing with clean water, use a clean towel or paper towel to absorb the moisture. Hard medicinal materials: such as amber, rhubarb, bone drynaria, etc., can be cut with a knife or crushed with a medicinal material grinder. The crushed medicinal materials help to quickly release the active ingredients. Soft medicinal materials: such as wolfberry, angelica, etc. do not need to be cut and can be used directly. According to the weight requirements of each medicinal material, the medicinal materials should be packaged and marked clearly to avoid confusion. If there are many medicinal materials, it is recommended to record their weight one by one.

[0044] Specifically, in step S2, the decocting utensils are prepared: medicine pot: use a wide-mouthed deep pot, preferably a casserole or a stainless steel pot, so that the medicine liquid can be heated evenly, gauze bag: if there are substances with larger particles in the medicinal materials, such as amber, etc., they can be wrapped in a gauze bag to prevent the medicinal materials from scattering during the decoction process, filter: used to filter the medicinal liquid to prevent the dregs from entering the liquid for consumption, add water: after all the medicinal materials are placed in the medicine pot, add 500-600 ml of water (the amount of water is adjusted according to the size of the pot and the amount of medicinal materials) to ensure that the medicinal materials are completely immersed. Cold soaking with clean water for 30 minutes is conducive to the initial softening of the medicinal materials and the release of the active ingredients.

[0045] Specifically, the decoction process in step S3 is as follows: the first decoction: boil the liquid medicine with a high fire, turn to a low fire after the water boils, keep the water surface slightly open, and decoct for about 40-60 minutes. The pot lid can be covered, but a small gap should be left to prevent the liquid medicine from overflowing. The second decoction: after the first decoction is completed, the liquid medicine is filtered out. Then add about 300 ml of water, decoct again, adjust the firepower to medium and small fire, and the decoction time is 30 minutes. Filter: the liquid medicine after the two decoctions is mixed, and the residue is filtered using gauze or a filter. Keep the liquid medicine clear for drinking.

[0046] Specifically, the daily dosage in step S4: take 250 ml of liquid medicine each time, twice a day, morning and evening. The liquid medicine is best taken within 1 hour after a meal to reduce irritation to the gastrointestinal tract. Taking temperature: the liquid medicine should be taken warm, avoid overheating or overcooling, and the temperature between 40-50°C is more suitable. Overheated liquid medicine may destroy some effective ingredients, and overcooling may cause gastrointestinal discomfort. Keep taking it: For best results, it is recommended that patients continue to take it for 4-6 weeks. After the course of treatment, if the symptoms are relieved, the dosage can be reduced appropriately, and continue to take it for 2-3 weeks to consolidate the therapeutic effect, and cooperate with diet and lifestyle adjustments: During drug treatment, it is recommended that patients pay attention to calcium and vitamin D supplements, avoid excessive fatigue, exercise moderately, and maintain healthy eating habits.

[0047] Specifically, during the treatment in step S5, the patient should avoid consuming spicy and irritating foods, greasy foods, and excessive caffeine, etc., so as not to affect the efficacy of the medicine. It is recommended that the patient have regular follow-up during the use of the prescription, especially for joint changes in KBD. If there is discomfort or worsening symptoms, the treatment plan should be adjusted in time. While taking Chinese medicine, some physical therapy methods can be considered, such as hot compresses, massage, traction, etc., to relieve joint pain and stiffness.

[0048] Through the above technical scheme, in the present invention, the design of this prescription is based on the pathological characteristics of Kaschin-Beck disease, and comprehensively utilizes the compatibility of Chinese medicines that nourish the liver and kidney, promote blood circulation and remove blood stasis, and strengthen tendons and bones, aiming to improve joint function and promote bone repair by regulating the body's bone metabolism and relieving joint symptoms. Through the conditioning of Chinese medicine, it is expected to fundamentally improve the patient's bone health, alleviate the symptoms of Kaschin-Beck disease, and provide a relatively safe and effective treatment option.

[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof, characterized in that: Includes the following step: S1: Prepare raw materials: the raw materials include: Radix Rehmanniae Preparata, Angelica Sinensis, Fructus Lycii, Herba Mori, Eucommia Bark, Achyranthes Bidentatae, Radix Astragali, Radix Notoginseng, Rhizoma Drynariae, Radix Rhei, Caulis Piperis, Rhizoma Anemarrhenae and Amber; S2: Preparing medicinal materials: Purchase all the raw materials in step S1, ensure the quality of the Chinese medicinal materials, and wash them. For hard medicinal materials such as rhubarb, Panax notoginseng, amber, etc., they can be softened with water first to facilitate the extraction of their effective ingredients. At the same time, the medicinal materials should be cut or crushed to facilitate decoction and release of medicinal effects; S3: Decoction of medicinal materials: first mix all the medicinal materials, put them into a medicine pot, add clean water, the water volume is controlled to 500-600 ml, soak the medicinal materials for 30 minutes before decoction, boil the medicinal materials over high heat first, after the medicinal liquid boils, turn to low heat and slowly decoct for 40-60 minutes, filter out the decoction, add 300 ml of water again, decoct for 30 minutes, filter again, mix the decoctions after two decoctions, and after merging, take about 500 ml as one dose per day; S4: Dosage: Daily use: Patients should take it twice a day, morning and evening, 250 ml each time. It is best to take it one hour after a meal to reduce gastrointestinal irritation. Treatment course: It is recommended to take it for 4-6 weeks as a course of treatment. After the symptoms are alleviated, the dosage can be appropriately reduced and continued for 2-3 weeks to consolidate the therapeutic effect; S5: Precautions for use: During the period of taking this prescription, you should pay attention to a reasonable diet and avoid excessive intake of high-salt and high-fat foods. Patients should avoid strenuous exercise during the medication period and appropriately increase low-intensity exercise, such as walking, swimming, etc., to avoid excessive burden on the joints.

2. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: The specific amounts of the raw materials in step S1 are: 15g of Rehmannia root, 12g of Angelica sinensis, 10g of Lycium barbarum, 12g of Viscum album, 10g of Eucommia ulmoides, 12g of Achyranthes bidentata, 15g of Astragalus membranaceus, 6g of Panax notoginseng, 15g of Drynaria fortunei, 6g of Rhubarb, 15g of Piper mesenteriae serrata, 10g of Anemarrhena asphodeloides and 3g of Amber.

3. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: Cleaning in step S1: Some medicinal materials (such as mistletoe, wolfberry, etc.) need to be cleaned, but avoid scrubbing hard to avoid losing the active ingredients. After washing with clean water, use a clean towel or paper towel to absorb the moisture. Hard medicinal materials: such as amber, rhubarb, bone drynaria, etc., can be cut with a knife or crushed with a medicinal material crusher. The crushed medicinal materials help to quickly release the active ingredients. Soft medicinal materials: such as wolfberry, angelica, etc. do not need to be cut and can be used directly. According to the weight requirements of each medicinal material, the medicinal materials should be packaged and marked clearly to avoid confusion. If there are many medicinal materials, it is recommended to record their weight one by one.

4. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: In step S2, prepare the medicine decocting utensils: medicine pot: use a wide-mouthed deep pot, preferably a casserole or a stainless steel pot, so that the medicine liquid can be heated evenly, gauze bag: if there are substances with larger particles in the medicinal materials, such as amber, etc., they can be wrapped in a gauze bag to prevent the medicinal materials from scattering during the decocting process, filter: used to filter the medicinal liquid to prevent the dregs from entering the liquid for consumption, add water: after all the medicinal materials are placed in the medicine pot, add 500-600 ml of water (the amount of water is adjusted according to the size of the pot and the amount of medicinal materials) to ensure that the medicinal materials are completely immersed. Cold soaking with water for 30 minutes is conducive to the initial softening of the medicinal materials and the release of the active ingredients.

5. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: Decoction process in step S3: First decoction: boil the liquid medicine with high heat, turn to low heat after the water boils, keep the water surface slightly open, and decoct for about 40-60 minutes. The pot can be covered, but a small gap should be left to prevent the liquid medicine from overflowing. Second decoction: after the first decoction is completed, filter out the liquid medicine. Then add about 300 ml of water, decoct again, adjust the firepower to medium and small heat, and the decoction time is 30 minutes. Filter: the liquid medicine after the two decoctions is mixed, and the residue is filtered using gauze or a filter. Keep the liquid medicine clear for drinking.

6. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: Daily dosage in step S4: 250 ml of liquid medicine each time, taken twice a day, morning and evening. The liquid medicine is best taken within 1 hour after a meal to reduce irritation to the gastrointestinal tract. Taking temperature: The liquid medicine should be taken warm, avoid overheating or overcooling, and the temperature between 40-50°C is more suitable. Overheated liquid medicine may destroy some effective ingredients, and overcooling may cause gastrointestinal discomfort. Keep taking it: For best results, it is recommended that patients continue to take it for 4-6 weeks. After the course of treatment, if the symptoms are relieved, the dosage can be reduced appropriately, and it should be continued for 2-3 weeks to consolidate the therapeutic effect, and diet and lifestyle adjustments should be made: During drug treatment, patients are advised to pay attention to calcium and vitamin D supplementation, avoid excessive fatigue, exercise moderately, and maintain healthy eating habits.

7. A Chinese medicine for treating Kaschin-Beck disease and a preparation method thereof according to claim 1, characterized in that: During the treatment in step S5, the patient should avoid consuming spicy and irritating foods, greasy foods, and excessive caffeine, etc., so as not to affect the efficacy of the medicine. It is recommended that the patient have regular follow-up during the use of the prescription, especially for joint changes in KBD. If there is discomfort or worsening symptoms, the treatment plan should be adjusted in time. While taking Chinese medicine, some physical therapy methods can be considered, such as hot compresses, massage, traction, etc., to relieve joint pain and stiffness.