A blood component separation system and control method

Abstract

The present invention discloses a blood component separation system and a control method, belonging to the field of blood separation. The system includes a centrifugal device, a blood supply pipeline, an air detector valve, and a blood pump. The liquid outlet of the centrifugal device is connected to a separation pipeline, on which a first plasma bag and a second plasma bag are successively connected, a centrifugal pressure sensor, a centrifugal high-speed camera, and an erythrocyte sensor. It further includes a control center, which includes a data acquisition module, a data analysis module, and a centrifugal control module. The control method includes steps S1 - S4. The present invention realizes the dynamic intelligent regulation and automatic control of the blood component centrifugal separation system, uses image recognition technology to optimize the centrifugation effect, which is superior to the photoelectric recognition technology of the prior art, ensures the centrifugation quality while avoiding over-centrifugation, and effectively guarantees the quality and activity of the separated blood components.

Description

Technical Field

[0001] The present invention relates to the field of blood separation, and particularly to a blood component separation system and a control method thereof. Background Art

[0002] Blood component separation technology is widely used in multiple aspects such as blood transfusion therapy, diagnosis and treatment of blood diseases; traditional blood component separation methods often have many drawbacks, with low separation efficiency, poor precision, and being extremely likely to damage blood samples. Some early centrifugal separation devices, due to the lack of dynamic regulation of centrifugal force and the precise control of key parameters such as flow rate and tube pressure during the separation process, made the separation boundaries between different blood components unclear, and blood cells frequently ruptured during high-speed rotation, seriously affecting the quality and activity of the separated components. Moreover, the existing blood component separation systems have a low degree of automation, it is difficult to control the injection of anticoagulants, and manual intervention is frequent, which not only increases the workload of operators, but also easily introduces human errors, greatly reducing the overall reliability and stability. Summary of the Invention

[0003] In view of the above deficiencies in the prior art, the present invention provides a blood component separation system and a control method thereof to achieve dynamic intelligent control of the blood component separation process.

[0004] To achieve the above invention purpose, the technical solutions adopted by the present invention are as follows:

[0005] Provide a blood component separation system, which includes a centrifugal device. The liquid inlet of the centrifugal device is connected to the blood supply end through a blood supply pipeline. An air detector B, a valve A, and a blood pump are sequentially arranged on the blood supply pipeline. The liquid outlet of the centrifugal device is connected to a separation pipeline. A first bifurcation pipe and a second bifurcation pipe are sequentially connected to the separation pipeline. The first bifurcation pipe and the second bifurcation pipe are respectively connected to a first plasma bag and a second plasma bag, and valves B and C are respectively arranged on the first bifurcation pipe and the second bifurcation pipe. A centrifugal pressure sensor for detecting the pressure inside the centrifugal cavity and a centrifugal high-speed camera for taking images of the centrifugal separation effect of the components in the blood are arranged inside the centrifugal device. A red blood cell sensor is arranged at the liquid outlet of the centrifugal device;

[0006] It further includes a control center, which includes a data acquisition module, a data analysis module, and a centrifugal control module. The centrifugal high-speed camera, the air detector B, the centrifugal pressure sensor, and the red blood cell sensor are all electrically connected to the data acquisition module, and the centrifugal control module is electrically connected to the centrifugal device.

[0007] Furthermore, a tube pressure monitor is arranged on the blood supply pipeline, and the tube pressure monitor is electrically connected to the data acquisition module.

[0008] Further, an anticoagulant pump is connected between the air detector B and the blood supply end through an anticoagulant pipeline, and an air detector A is arranged on the anticoagulant pipeline between the anticoagulant pump and the air detector B. The anticoagulant pump is connected to an anticoagulant supply device, and a liquid level sensor is arranged in the anticoagulant supply device. Both the air detector A and the liquid level sensor are electrically connected to a data acquisition module.

[0009] Further, it further includes a fluid infusion device, the fluid infusion device is connected to a fluid infusion pump, the fluid infusion pump is connected to a separation pipeline through a fluid infusion pipeline, and a valve D is arranged on the separation pipeline.

[0010] Further, it further includes a reinfusion pump, the reinfusion pump is connected to the liquid outlet of the centrifugation device, and the reinfusion pump is connected to the blood supply pipeline at the blood supply end through a valve E, and the remaining blood components in the centrifugation device are reinfused to the blood donor through the reinfusion pump.

[0011] Provide a control method for a blood component separation system, which includes:

[0012] Step S1: During the process of collecting blood at the blood supply end, the blood pump transfuses blood into the centrifugation device, and the anticoagulant pump extracts anticoagulant and inputs it into the blood supply pipeline, so that the blood in the blood supply pipeline is mixed with the anticoagulant. The pipe pressure monitor collects the pipe pressure of the blood supply pipeline in real time, and constructs an optimal control model of the blood pump and an optimal control model of the anticoagulant pump based on the pipe pressure;

[0013] Step S2: Based on the optimal control model of the blood pump and the optimal control model of the anticoagulant pump, regulate the power of the blood pump and the anticoagulant pump, and input the collected blood into the centrifugation device;

[0014] Step S3: After the blood collection is completed, close valve A, start the centrifugation device to rotate, perform centrifugal separation on the blood components, the centrifugal high-speed camera takes the centrifugal image of the blood in real time, analyze the centrifugal effect of the blood components according to the centrifugal image, and regulate the centrifugal power of the centrifugation device;

[0015] Step S4: After the centrifugation device completes the separation of the blood components with the centrifugal power meeting the centrifugation requirements, open valve B and valve C in sequence, and discharge the separated blood components into the first plasma bag and the second plasma bag respectively.

[0016] Further, step S1 includes:

[0017] Step S11: During the process of collecting blood at the blood supply end, the blood pump transfuses blood into the centrifugation device, and the anticoagulant pump extracts anticoagulant and inputs it into the blood supply pipeline, so that the blood in the blood supply pipeline is mixed with the anticoagulant. The pipe pressure monitor collects the pipe pressure of the blood supply pipeline in real time , t is the moment of pipe pressure collection;

[0018] Step S12: According to the pipe pressure Construct the optimal control model of the blood pump;

[0019] ;

[0020] Among them, is t the tube pressure fluctuation value at the +1 moment, is the efficiency of the blood pump, is the rated flow rate of blood at the blood collection end, represents taking the minimum value, represents taking the maximum value, is t the tube pressure fluctuation value at the moment of, is t the tube pressure fluctuation value at the -1 moment, is t the power regulation value of the blood pump at the +1 moment, is t the tube pressure at the -1 moment, is t the tube pressure at the -2 moment, is the maximum power of the blood pump;

[0021] Step S13: According to the t power of the blood pump at the +1 moment output by the optimal control model of the blood pump , is the rated power of the blood pump, calculate the true flow rate of the blood in the blood transfusion pipeline;

[0022] ;

[0023] Among them, r is the radius of the blood transfusion pipeline, L is the length of the blood transfusion pipeline, is the viscosity of the blood flowing in the blood transfusion pipeline;

[0024] Step S14: According to the true flow rate of the blood, construct the optimal control model of the anticoagulant pump;

[0025] ;

[0026] Among them, is the power of the anticoagulant pump, is the density of the anticoagulant, g is the acceleration of gravity, is the proportionality coefficient of the anticoagulant to be added to the blood, H is the elevation during the anticoagulant delivery process, is the efficiency of the anticoagulant pump, is the influence coefficient of the tube pressure fluctuation of the blood transfusion pipeline on the anticoagulant delivery.

[0027] Further, step S3 includes:

[0028] Step S31: The centrifugal high-speed camera takes real-time centrifugal images of the blood, grayscales the centrifugal images to obtain grayscale images, and obtains the grayscale values of each pixel on the grayscale images. An identification area is established on the grayscale images. The identification area is a strip area perpendicular to the blood component stratification direction;

[0029] Step S32: Set the color grayscale value after the separation of the target component in the blood. According to the grayscale values of each pixel in the identification area, filter the pixel sets in the areas where each blood component is located;

[0030] ;

[0031] Among them, e is the type of blood component, is the e th pixel set in the area where the E th blood component is located, is the number of pixels in the pixel set, is the pixel in the pixel set is the grayscale value of the pixel is the color grayscale value after the separation of the e th blood component in the pixel set, is the color grayscale difference threshold;

[0032] Step S33: Establish a pixel coordinate set according to the coordinates of the pixels in the pixel set , filter the maximum coordinate and the minimum coordinate of the pixel coordinates in the pixel coordinate set in the length direction of the identification area, ;

[0033] Step S34: Draw two wide border lines of the blood component separation area that pass through the maximum coordinate and the minimum coordinate and are perpendicular to the long side of the identification area in the identification area. The two wide border lines and the long border lines on both sides of the identification area enclose the blood component separation area;

[0034] Step S35: Divide the blood component separation area of each blood component in the identification area, and calculate the centrifugation effect coefficient f according to the purity of the pixels in each blood component separation area;

[0035] ;

[0036] Among them, is the purity coefficient in the blood component separation area, W is the number of pixels in the blood component separation area that do not belong to the e th type of blood component pixel, U is the number of pixels in the blood component separation area, is the pixel in the blood component separation area that does not belong to the e th type of blood component, is the pixel set in the blood component separation area, is the weight of the centrifugation effect, X is the number of types of blood components separated by centrifugation;

[0037] Step S36: Set the threshold of the centrifugation effect coefficient f 阈值 ;

[0038] If , the centrifugal power of the centrifugal device reaches the centrifugation requirement;

[0039] If , the centrifugal power of the centrifugal device does not reach the centrifugation requirement. The centrifugal device needs to adjust the centrifugal power, and the centrifugal power adjustment of the centrifugal device satisfies , where is the adjustment coefficient of the centrifugal power, , n is the number of times of centrifugal image acquisition, is the n th centrifugal power of the centrifugal device after the centrifugal power adjustment, and return to step S31.

[0040] The beneficial effects of the present invention are as follows: The present invention realizes the dynamic intelligent regulation and automatic control of the blood component centrifugation separation system. By constructing the optimal control model of the blood pump and the anticoagulant pump, it adapts to the pressure fluctuation in the blood transfusion pipeline. By dynamically adjusting the power of the blood pump, the flow rate fluctuation is reduced, and by dynamically adjusting the power of the anticoagulant pump, it adapts to the blood flow rate fluctuation, improving the accuracy of anticoagulant delivery. Moreover, the image recognition technology is used to optimize the centrifugation effect, which is superior to the existing optoelectronic recognition technology. While avoiding over-centrifugation, it ensures the centrifugation quality, effectively guaranteeing the quality and activity of the separated blood components. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 is the schematic diagram of the blood component separation system.

[0042] Figure 2 is the control principle block diagram of the blood component separation system.

[0043] Figure 3Schematic diagram of the effect of blood component separation.

[0044] Among them, 1 is the liquid inlet, 2 is the liquid outlet, 3 is the centrifugal chamber, 4 is the plasma layer, 5 is the platelet layer, and 6 is the red blood cell layer. Specific implementation manners

[0045] The specific implementation manners of the present invention will be described below to facilitate those skilled in the art of this technical field to understand the present invention. However, it should be clear that the present invention is not limited to the scope of the specific implementation manners. For those of ordinary skill in the art of this technical field, as long as various changes are within the spirit and scope of the present invention defined and determined by the appended claims, these changes are obvious, and all inventions and creations using the concept of the present invention are within the scope of protection.

[0046] As Figure 1 shown, a blood component separation system includes a centrifugal device. The liquid inlet 1 of the centrifugal device is connected to the blood supply end through a blood supply pipeline. An air detector B, a valve A, and a blood pump are sequentially arranged on the blood supply pipeline. A separation pipeline is connected to the liquid outlet 2 of the centrifugal device. A first bifurcation pipe and a second bifurcation pipe are sequentially connected to the separation pipeline. The first bifurcation pipe and the second bifurcation pipe are respectively connected to a first plasma bag and a second plasma bag, and a valve B and a valve C are respectively arranged on the first bifurcation pipe and the second bifurcation pipe. A centrifugal pressure sensor for detecting the pressure in the internal centrifugal chamber 3 and a centrifugal high-speed camera for photographing the image of the centrifugal separation effect of the components in the blood are arranged in the centrifugal device. A red blood cell sensor is arranged on the liquid outlet 2 of the centrifugal device.

[0047] The air detector B is used to detect the air content in the blood transfusion pipeline to determine whether there is a large amount of air. The valve A controls the on-off of the blood transfusion pipeline, and the blood pump provides power for the blood transfusion process. Generally, the separation of blood components generally requires separating out the plasma layer 4, the platelet layer 5, and the red blood cell layer 6. As Figure 3 shown, the plasma has the largest mass. During the centrifugal separation process, the plasma layer 4 is located inside, the platelets are the second and located in the middle layer, and the red blood cells have the smallest mass, and the separated red blood cell layer 6 is located on the outermost side.

[0048] As Figure 2As shown in the figure, it further includes a control center, which includes a data acquisition module, a data analysis module, and a centrifugation control module. The centrifugal high-speed camera, air detector B, centrifugal pressure sensor, and red blood cell sensor are all electrically connected to the data acquisition module, and the centrifugation control module is electrically connected to the centrifugation device. The centrifugation control module is used to control the centrifugal power of the centrifugation device, and the data analysis module is used to analyze the data collected by the data acquisition module and output control instructions. The centrifugal pressure sensor is used to monitor the centrifugal pressure in the centrifugal chamber 3 during centrifugation to prevent the centrifugal chamber 3 from bursting due to excessive centrifugal speed. In this embodiment, the centrifugal chamber 3 can adopt a blood centrifugation cup of the prior art, and the centrifugation cup is made of a transparent material and used as a disposable consumable.

[0049] A tube pressure monitor is provided on the blood supply pipeline. The tube pressure monitor is electrically connected to the data acquisition module and is used to detect the pressure on the blood transfusion pipeline and feedback it to the data acquisition module in real time.

[0050] An anticoagulant pump is connected between the air detector B and the blood supply end through an anticoagulant pipeline, and an air detector A is provided on the anticoagulant pipeline between the anticoagulant pump and the air detector B to monitor whether there is air in the anticoagulant pipeline. The anticoagulant pump is connected to the anticoagulant supply device, and a liquid level sensor is provided in the anticoagulant supply device. The air detector A and the liquid level sensor are both electrically connected to the data acquisition module, and the liquid level sensor monitors the liquid level height of the anticoagulant in the anticoagulant supply device.

[0051] It further includes a fluid infusion device, which is connected to a fluid infusion pump. The fluid infusion pump is connected to the separation pipeline through a fluid infusion pipeline, and a valve D is provided on the separation pipeline. When the blood donor needs fluid infusion, after the blood component separation is completed, the residual components are emptied, and the fluid infusion pump can reverse the fluid infusion to the blood donor.

[0052] It further includes a reinfusion pump, which is connected to the liquid outlet of the centrifugation device. The reinfusion pump is connected to the blood supply pipeline at the blood supply end through a valve E. The remaining blood components in the centrifugation device are reinfused to the blood donor through the reinfusion pump, and the valve E is opened only during reinfusion and closed at other times.

[0053] A control method for a blood component separation system includes:

[0054] Step S1: During the process of collecting blood at the blood supply end, blood is transfused into the centrifugation device through a blood pump, and the anticoagulant pump extracts anticoagulant and inputs it into the blood supply pipeline to mix the blood in the blood supply pipeline with the anticoagulant. The tube pressure monitor collects the tube pressure of the blood supply pipeline in real time, and an optimal control model of the blood pump and an optimal control model of the anticoagulant pump are constructed based on the tube pressure. Step S1 specifically includes:

[0055] Step S11: During the process of blood collection at the blood supply end, the blood pump transfuses blood into the centrifugal device, and the anticoagulant pump extracts anticoagulant and inputs it into the blood supply pipeline, so that the blood in the blood supply pipeline is mixed with the anticoagulant, and the pipeline pressure monitor collects the pipeline pressure of the blood supply pipeline in real time , t is the moment of pipeline pressure collection;

[0056] Step S12: According to the pipeline pressure construct the optimal control model of the blood pump;

[0057] ;

[0058] Among them, is t the pipeline pressure fluctuation value at the +1 moment, is the efficiency of the blood pump, is the rated flow rate of the blood at the blood collection end, represents taking the minimum value, represents taking the maximum value, is t the pipeline pressure fluctuation value at the moment, is t the pipeline pressure fluctuation value at the -1 moment, is t the power regulation value of the blood pump at the +1 moment, is t the pipeline pressure at the -1 moment, is t the pipeline pressure at the -2 moment, is the maximum power of the blood pump;

[0059] Step S13: According to the power t of the blood pump at the +1 moment output by the optimal control model of the blood pump , is the rated power of the blood pump, and calculate the actual flow rate of the blood in the blood transfusion pipeline ;

[0060] ;

[0061] Among them, r is the radius of the blood transfusion pipeline, L is the length of the blood transfusion pipeline, is the viscosity of the blood flowing in the blood transfusion pipeline;

[0062] Step S14: According to the actual flow rate of the blood construct the optimal control model of the anticoagulant pump;

[0063] ;

[0064] Among them, is the power of the anticoagulant pump, is the density of the anticoagulant, g is the acceleration due to gravity, is the proportionality coefficient of the anticoagulant to be added to the blood, H is the elevation during the anticoagulant delivery process, is the efficiency of the anticoagulant pump, is the influence coefficient of the pressure fluctuation in the blood transfusion pipeline on the anticoagulant delivery. The pressure fluctuation in the blood transfusion pipeline will directly affect the blood flow rate. When the pressure in the mathematical pipeline increases, it will reverse the resistance to the anticoagulant and reduce the flow rate of the anticoagulant delivery. Generally, the influence coefficient takes a value of 0.1 - 0.5. The greater the pressure fluctuation in the blood transfusion pipeline, the greater the influence coefficient is. Using the optimal control model of the anticoagulant pump, according to the actual blood flow rate in the blood transfusion pipeline, dynamically regulate the power of the anticoagulant pump.

[0065] Step S2: Based on the optimal control model of the blood pump and the optimal control model of the anticoagulant pump, regulate the power of the blood pump and the anticoagulant pump, and input the collected blood into the centrifugal device.

[0066] Step S3: After the blood collection is completed, close valve A, start the centrifugal device to rotate, perform centrifugal separation on the blood components. The centrifugal high-speed camera takes real-time pictures of the centrifuged blood, analyzes the centrifugal effect of the blood components according to the centrifuged images, and regulates the centrifugal power of the centrifugal device. Step S3 specifically includes:

[0067] Step S31: The centrifugal high-speed camera takes real-time pictures of the centrifuged blood, performs grayscale processing on the centrifuged images to obtain grayscale images, and obtains the grayscale values of each pixel on the grayscale images. Establish a recognition area on the grayscale image. The recognition area is a strip area perpendicular to the direction of blood component stratification;

[0068] Step S32: Set the color grayscale value after the successful separation of the target component in the blood. According to the grayscale values of each pixel in the recognition area, screen the pixel sets of the areas where each blood component is located;

[0069] ;

[0070] Among them, e is the type of blood component, is the e th type of blood component, E is the number of pixels in the pixel set, is the pixel in the pixel set, is the pixel in the pixel set 's grayscale value, is the eThe color grayscale value after successful separation of a blood component is used as the standard value for evaluating the color grayscale values of different separated blood components. is the color grayscale difference threshold, serving as the allowable value for color grayscale differences. If the color grayscale value exceeds the threshold it indicates pixels that are not of the same blood component;

[0071] Step S33: Based on the pixels within the pixel set establish a pixel coordinate set , and screen the maximum coordinate and the minimum coordinate of the pixel coordinates within the pixel coordinate set in the length direction of the recognition area; ;

[0072] Step S34: Draw two width boundary lines of the blood component separation area that pass through the maximum coordinate and the minimum coordinate respectively and are perpendicular to the long side of the recognition area within the recognition area. The two width boundary lines and the long boundary lines on both sides of the recognition area enclose the blood component separation area; as Figure 3 shown, in this embodiment, the image areas of the separated plasma layer 4, platelet layer 5, and red blood cell layer 6 within the recognition area are distributed from left to right in sequence.

[0073] Step S35: Divide the blood component separation area of each blood component within the recognition area, and calculate the centrifugation effect coefficient based on the purity of the pixels within each blood component separation area f ;

[0074] ;

[0075] Among them, is the purity coefficient within the blood component separation area, W is the number of pixels in the blood component separation area that do not belong to the e th blood component, U is the number of pixels within the blood component separation area, are the pixels in the blood component separation area that do not belong to the e th blood component. In this embodiment, e = 3, is the pixel set within the blood component separation area, is the weight of the centrifugation effect, X is the number of types of blood components separated by centrifugation;

[0076] Step S36: Set the threshold f 阈值 of the centrifugation effect coefficient;

[0077] If , the centrifugal power of the centrifugal device reaches the centrifugation requirement;

[0078] If , the centrifugal power of the centrifugal device does not reach the centrifugation requirement. The centrifugal device needs to adjust the centrifugal power, and the centrifugal power adjustment of the centrifugal device satisfies , where is the adjustment coefficient of the centrifugal power, , n is the number of times of centrifugal image acquisition, is the n th centrifugal power of the centrifugal device after the centrifugal power adjustment, and return to step S31.

[0079] Step S4: After the centrifugal device completes the separation of blood components with the centrifugal power that meets the centrifugation requirement, open valve B and valve C in sequence, and discharge the separated blood components into the first plasma bag and the second plasma bag respectively. During centrifugation, the inner plasma layer 4 is first discharged into the first plasma bag, and the red blood cell sensor monitors the content of red blood cells in the plasma flowing into the first plasma bag in real time. When the content of red blood cells is too high, it indicates that the plasma and platelets have all entered the first plasma bag, then close valve B, and the first plasma bag obtains platelet-rich plasma. The remaining red blood cells can be returned to the blood donor. After the first plasma bag is full, valve C can be opened to input into the second plasma bag.

[0080] The present invention realizes the dynamic intelligent regulation and automatic control of the blood component centrifugation separation system. By constructing an optimal control model of the blood pump and the anticoagulant pump, it adapts to the pressure fluctuation in the blood transfusion pipeline, reduces the flow rate fluctuation by dynamically adjusting the power of the blood pump, and adapts to the blood flow rate fluctuation by dynamically adjusting the power of the anticoagulant pump, improving the accuracy of anticoagulant delivery. Moreover, the image recognition technology is used to optimize the centrifugation effect, which is superior to the existing optoelectronic recognition technology, ensuring the centrifugation quality while avoiding over-centrifugation, and effectively guaranteeing the quality and activity of the separated blood components.

Claims

1. A control method for a blood component separation system, the blood component separation system including a centrifugation device, the liquid inlet of the centrifugation device being connected to the blood supply end through a blood supply pipeline, an air detector B, a valve A, and a blood pump being sequentially arranged on the blood supply pipeline, a separation pipeline being connected to the liquid outlet of the centrifugation device, a first branch pipe and a second branch pipe being sequentially connected to the separation pipeline, the first branch pipe and the second branch pipe being respectively connected to a first plasma bag and a second plasma bag, and a valve B and a valve C being respectively arranged on the first branch pipe and the second branch pipe, a centrifugal pressure sensor for detecting the pressure inside the internal centrifugation cavity and a centrifugal high-speed camera for taking images of the centrifugal separation effect of the components in the blood being arranged inside the centrifugation device, and a red blood cell sensor being arranged at the liquid outlet of the centrifugation device; It further includes a control center, the control center including a data acquisition module, a data analysis module, and a centrifugation control module, the centrifugal high-speed camera, the air detector B, the centrifugal pressure sensor, and the red blood cell sensor being electrically connected to the data acquisition module, and the centrifugation control module being electrically connected to the centrifugation device; Analyze the centrifugation effect of blood components according to the centrifugation images and regulate the centrifugation power of the centrifugation device; After the centrifugation device completes the separation of blood components with a centrifugation power that meets the centrifugation requirements, sequentially open valve B and valve C, and discharge the separated blood components into the first plasma bag and the second plasma bag respectively. During centrifugation, the plasma layer located inside is first discharged into the first plasma bag. The red blood cell sensor monitors in real time the content of red blood cells in the plasma flowing into the first plasma bag. When the content of red blood cells is too high, it indicates that all the plasma and platelets have entered the first plasma bag. Then close valve B, and the first plasma bag obtains platelet-rich plasma, and the remaining red blood cells can be transfused back to the blood donor. After the first plasma bag is full, open valve C and input it into the second plasma bag; A pipe pressure monitor is arranged on the blood supply pipeline, and the pipe pressure monitor is electrically connected to the data acquisition module; An anticoagulation pump is connected between the air detector B and the blood supply end through an anticoagulation pipeline, and an air detector A is arranged on the anticoagulation pipeline between the anticoagulation pump and the air detector B. The anticoagulation pump is connected to an anticoagulant supply device, and a liquid level sensor is arranged inside the anticoagulant supply device. The air detector A and the liquid level sensor are both electrically connected to the data acquisition module; It further includes a liquid supplement device, the liquid supplement device being connected to a liquid supplement pump, the liquid supplement pump being connected to the separation pipeline through a liquid supplement pipeline, and a valve D being arranged on the separation pipeline; It further includes a reinfusion pump, the reinfusion pump being connected to the liquid outlet of the centrifugation device, and the reinfusion pump being connected to the blood supply pipeline of the blood supply end through a valve E. The remaining blood components in the centrifugation device are transfused back to the blood donor through the reinfusion pump; It is characterized in that including: Step S1: During the process of collecting blood at the blood supply end, the blood pump is used to transfuse blood into the centrifugation device, and the anticoagulation pump extracts anticoagulant and inputs it into the blood supply pipeline, so that the blood in the blood supply pipeline is mixed with the anticoagulant. The pipe pressure monitor collects the pipe pressure of the blood supply pipeline in real time, and constructs an optimal control model for the blood pump and an optimal control model for the anticoagulation pump based on the pipe pressure; Step S2: Based on the optimal control models of the blood pump and the anticoagulant pump, regulate the power of the blood pump and the anticoagulant pump, and input the collected blood into the centrifugal device; Step S3: After the blood collection is completed, close valve A, start the centrifugal device to rotate, centrifuge the blood components, the centrifugal high-speed camera takes real-time centrifugal images of the blood, analyze the centrifugal effect of the blood components according to the centrifugal images, and regulate the centrifugal power of the centrifugal device; Step S4: After the centrifugal device completes the separation of the blood components with the centrifugal power meeting the centrifugal requirements, open valve B and valve C in sequence, and discharge the separated blood components into the first plasma bag and the second plasma bag respectively; The said step S1 includes: Step S11: During the process of collecting blood at the blood supply end, blood is transfused into the centrifugal device through a blood pump, and an anticoagulant pump extracts anticoagulant and inputs it into the blood supply pipeline, so that the blood in the blood supply pipeline is mixed with the anticoagulant, and the tube pressure monitor collects the tube pressure of the blood supply pipeline in real time , t is the moment when the tube pressure is collected; Step S12: Construct an optimal control model of the blood pump according to the tube pressure ; ； Wherein, is t the tube pressure fluctuation value at the +1 moment, is the efficiency of the blood pump, is the rated flow rate of the blood at the blood collection end, means taking the minimum value, means taking the maximum value, is t the tube pressure fluctuation value at the moment of is t the tube pressure fluctuation value at the -1 moment, is t the power regulation value of the blood pump at the +1 moment, is t the tube pressure at the -1 moment, is t the tube pressure at the -2 moment, is the maximum power of the blood pump; Step S13: According to the power of the blood pump at the t +1 moment output by the optimal control model of the blood pump , which is the rated power of the blood pump, calculate the true blood flow in the blood transfusion pipeline ; ； Among them, r is the radius of the blood transfusion pipeline, L is the length of the blood transfusion pipeline, is the viscosity of blood flowing in the blood transfusion pipeline; Step S14: Based on the actual blood flow rate Construct an optimal control model for the anticoagulation pump; ； Among them, is the power of the anticoagulant pump, is the density of the anticoagulant, g is the acceleration of gravity, is the proportionality coefficient of the anticoagulant to be added to the blood, H is the elevation during the anticoagulant delivery process, is the efficiency of the anticoagulant pump, is the influence coefficient of the pressure fluctuation in the blood transfusion pipeline on the anticoagulant delivery; The said step S3 includes: Step S31: The centrifugal high-speed camera takes real-time centrifugal images of the blood, performs grayscale processing on the centrifugal images to obtain grayscale images, and obtains the grayscale values of each pixel on the grayscale images. Establish a recognition area on the grayscale image, and the recognition area is a strip area perpendicular to the blood component stratification direction; Step S32: Set the color grayscale value after the successful separation of the target components in the blood. According to the grayscale values of each pixel in the recognition area, screen the pixel sets of the areas where each blood component is located; ； Among them, e is the type of blood component, is the set of pixels in the area where the e th blood component is located, E is the number of pixels in the pixel set, is the pixel in the pixel set, is the pixel in the pixel set 's gray value, is the color gray value after the e th blood component in the pixel set is successfully separated, is the color gray difference threshold; Step S33: Based on the pixels inside the pixel set, establish a pixel coordinate set , and filter the maximum coordinate and the minimum coordinate in the length direction of the recognition area among the pixel coordinates in the pixel coordinate set , ; Step S34: Draw two lines perpendicular to the long side of the recognition area and passing through the maximum coordinate and the minimum coordinate within the recognition area to form the width boundary lines of the blood component separation area. The two width boundary lines and the long boundary lines on both sides of the recognition area enclose the blood component separation area; Step S35: Divide the blood component separation areas of each blood component within the recognition area, and calculate the centrifugation effect coefficient according to the purity of the pixels within each blood component separation area f ; ； Among them, is the purity coefficient in the blood component separation area, W is the number of pixels in the blood component separation area that do not belong to the e th type of blood component pixel, U is the number of pixels in the blood component separation area, is the pixel that does not belong to the e th type of blood component in the blood component separation area, is the pixel set in the blood component separation area, is the weight of the centrifugation effect, X is the number of types of blood components separated by centrifugation; Step S36: Set the threshold of the centrifugal effect coefficient f 阈值 ; If , the centrifugal power of the centrifugal device meets the centrifugal requirements; If , the centrifugal power of the centrifugal device does not meet the centrifugal requirement. The centrifugal device needs to adjust the centrifugal power, and the adjustment of the centrifugal power of the centrifugal device satisfies , where is the adjustment coefficient of the centrifugal power, , n is the number of times of centrifugal image acquisition, is the centrifugal power of the centrifugal device after the n th adjustment of the centrifugal power, and return to step S31.

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