A test reagent card for body composition metabolism
The modular body composition metabolism test kit solves the problem of the wide variety of test kits in multi-item joint testing, achieving standardization of test kits and automated instrument testing, reducing costs and improving assembly convenience.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- 北京中生金域诊断技术股份有限公司
- Filing Date
- 2024-12-30
- Publication Date
- 2026-06-26
AI Technical Summary
The existing dry chemical reagent cards are designed with a fixed structure, which means that multiple types of cards are needed for multi-item joint testing, making standardization difficult, increasing costs and hindering automated instrument testing.
A modular body composition metabolism detection reagent card is provided, including a reagent card base mechanism and a solid phase hole component, which are fixedly set by spacers to achieve flexible combination and standardized design of the reagent cards.
It enables standardized production of reagent cards, reduces costs, supports automated instrument testing, and improves flexibility and ease of assembly.
Smart Images
Figure CN119804775B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of dry chemical equipment technology, and in particular to a modular body composition metabolism detection reagent card. Background Technology
[0002] Dry chemistry analysis techniques and methods are important in clinical laboratory testing. As opposed to wet chemistry techniques, dry chemistry involves directly adding liquid test samples to commercially available, dried reagent strips specifically designed for different tests. The moisture in the sample acts as a solvent, triggering a specific chemical reaction for analysis. This enzymatic-based approach is also known as dry reagent chemistry or solid-phase chemistry. Due to its high accuracy, speed, and ease of operation, dry chemistry analysis techniques and methods are widely used in various clinical tests. Dry chemistry reagents require reagent cards as carriers, which solidify the reagents on the card for ease of use and transport. The reagent card also serves as the reaction carrier in dry chemistry detection, playing a crucial role in the process.
[0003] With the increasing development of dry chemistry clinical projects and the growing application of multi-project combined testing, most commercially available reagent cards are designed with a fixed structure to meet the needs of specific projects. One reagent card can only be used for one combined testing project. For multiple combined testing projects, multiple different reagent cards are required, resulting in a wide variety of dry chemistry reagent cards that are difficult to standardize. This leads to higher reagent card costs and hinders the realization of automated instrument testing. Summary of the Invention
[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a modular body composition metabolism detection reagent card that can be used in combined body composition metabolism testing projects. It can realize the free combination of reagent cards according to the number of indicators of the combined testing projects, and realize the standardization of the reagent card's external size, thereby reducing costs and facilitating instrument automation.
[0005] The first aspect of the present invention is to provide an assemblable body component metabolism detection reagent card, comprising: a reagent card base mechanism (A) and a plurality of solid phase orifice components (B), wherein the plurality of solid phase orifice components (B) are fixedly disposed side by side at intervals on the upper surface of the reagent card base mechanism (A) by spacers, and are respectively used to carry single detection reagent cards including the same or a plurality of different body component metabolism detection reagents; the upper surface of the plurality of solid phase orifice components (B) is flush with the upper surface of the reagent card base mechanism (A).
[0006] Preferably, the plurality of solid phase pores (B) are uniformly arranged at equal intervals on the upper surface of the reagent card base mechanism (A).
[0007] Preferably, the plurality of solid phase holes (B) are uniformly arranged in a fan shape and in an equally spaced ring shape on the upper surface of the reagent card base mechanism (A), or in an equally spaced rectangular, semi-circular, single-ring, or multi-ring shape on the upper surface of the reagent card base mechanism (A).
[0008] Preferably, the plurality of solid phase holes (B) are disposed on one side of the upper surface of the reagent card base mechanism (A) rather than in the center; or disposed in the center of the upper surface of the reagent card base mechanism (A), while other components are arranged on both sides of the upper surface; or arranged in a semi-circular manner on both sides of the upper surface of the reagent card base mechanism (A), while other components are arranged in the center of the reagent card base mechanism (A).
[0009] Preferably, the reagent card base mechanism (A) and the solid phase orifice (B) are made of plastic, ceramic, glass, or inert polymer. The front of the reagent card is defined from top to bottom. If the reagent card is inspected from the front, the reagent card base mechanism (A) and the solid phase orifice (B) are made of transparent or opaque materials. If the reagent card is inspected from the back, the reagent card base mechanism (A) and the solid phase orifice (B) are made of transparent materials.
[0010] Preferably, the solid phase orifice (B) is a concave orifice, comprising a reagent solid phase portion (B1) and a solid phase orifice positioning handle (B2). The reagent solid phase portion (B1) is disposed at the bottom of the inner hole of the solid phase orifice (B), and the bottom of the inner hole is not connected to the outside. The reagent solid phase portion (B1) is used to solidify dry chemical reagents at the bottom of the inner hole. The solid phase orifice positioning handle (B2) is disposed on one side of the solid phase orifice (B) and extends outward, and is used to position the solid phase orifice (B) by engaging with the base fixing groove at the corresponding position during reagent card assembly.
[0011] Preferably, the reagent solid phase section (B1) includes a solid phase hole (B11) and a reagent solid phase surface (B12); the reagent solid phase is on the reagent solid phase surface (B12), and the solid phase hole (B11) is used to hold the liquid sample during the reaction.
[0012] Preferably, the solid phase pore (B11) is circular, rectangular, square, elliptical, or other irregular in shape.
[0013] Preferably, the reagent card base mechanism (A) includes an assembly hole (A1) and a base fixing groove (A2). After the solid phase hole component (B) is placed into the assembly hole (A1), the solid phase hole component positioning handle (B2) is engaged in the base fixing groove (A2) to perform the installation and positioning of the solid phase hole component (B).
[0014] Preferably, the reagent card base mechanism (A) is circular, rectangular, or square in shape.
[0015] A second aspect of the present invention is to provide the application of the modular body composition metabolism detection reagent card of the first aspect in both non-dry chemical body composition metabolism detection projects and dry chemical body composition metabolism detection projects.
[0016] The beneficial effects of the modular body composition metabolism detection reagent card of the present invention and its application are as follows:
[0017] (1) The modular design reduces the types of reagent cards for dry chemical joint testing items, realizes production standardization, and is conducive to promoting the automation of dry chemical instrument joint testing.
[0018] (2) The modular design can be added or reduced according to the needs of dry chemical joint inspection items. It has a simple structure, is easy to assemble, has good flexibility, reduces material waste, and helps to reduce manufacturing costs. Attached Figure Description
[0019] To more clearly illustrate the technical solutions in the specific embodiments or related technologies of the present invention, the drawings used in the description of the specific embodiments or related technologies will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.
[0020] Figure 1 This is a schematic diagram of a combined reagent card structure provided according to an embodiment of the present invention;
[0021] Figure 2 This is a schematic diagram of a solid-state hole structure provided according to an embodiment of the present invention;
[0022] Figure 3 This is a cross-sectional view of the reagent solid phase structure provided in an embodiment of the present invention;
[0023] Figure 4 This is a schematic diagram of the base structure provided according to an embodiment of the present invention;
[0024] Figure 5 This is a schematic diagram of the exploded structure of a combined reagent card assembly according to an embodiment of the present invention;
[0025] Figure 6 This is a schematic diagram illustrating an example structure of a three-item combined test kit provided according to an embodiment of the present invention;
[0026] Figure 7 This is a schematic diagram of an example structure of a five-item combined test kit provided according to an embodiment of the present invention;
[0027] Figure 8This is a schematic diagram of the modified design structure of a single-ring ten-well assembled reagent card according to an embodiment of the present invention;
[0028] Figure 9 This is a schematic diagram of the structure of a double-ring twelve-well reagent card provided according to an embodiment of the present invention. Detailed Implementation
[0029] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0030] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.
[0031] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.
[0032] Example 1
[0033] like Figure 1 As shown, this embodiment provides an assemblable body component metabolism detection reagent card, including: a base (A) and multiple solid phase orifice components (B), wherein the multiple solid phase orifice components (B) are fixedly arranged side by side at intervals on the upper surface of the base (A) by spacers, and are respectively used to carry single detection reagent cards including the same or multiple different body component metabolism detection reagents; the upper surface of the multiple solid phase orifice components (B) is flush with the upper surface of the base (A).
[0034] In a preferred embodiment, the plurality of solid phase holes (B) are uniformly arranged on the upper surface of the base (A) at equal intervals.
[0035] In this embodiment, multiple solid-phase orifice elements (B) are fan-shaped and evenly distributed in a ring-like arrangement on the upper surface of the base (A), positioned on one side of the upper surface rather than in the center. This facilitates the placement of other components in the areas where solid-phase orifice elements are not located. A total of six solid-phase orifice elements are provided, labeled with numbers 1-6, improving the compactness of the entire modular body component metabolism detection reagent card and facilitating miniaturized production. Of course, those skilled in the art should understand that they can also be arranged in a rectangular or semi-circular pattern with equal spacing, or placed in the center of the upper surface, with other components arranged on either side. Alternatively, two semi-circles can be arranged on either side of the upper surface, with other components placed in the center; all of these are within the scope of this invention.
[0036] In a preferred embodiment, both the base A and the solid-phase aperture B are made of plastic, ceramic, glass, or inert polymer. This embodiment uses transparent acrylic, and the bottom transmittance of the solid-phase aperture B is required to be above 95%. Depending on the actual needs of the testing equipment and reagents, testing can be performed from either the front or back of the reagent card. For front-side testing, an opaque material can be used to make the reagent card, such as... Figure 1 As shown, the front of the reagent card is defined from top to bottom, and the back is from bottom to top. If testing is performed from the back, the reagent card must be made of a transparent material. Transparency is not required for testing from the front. The material of the reagent card can be flexibly selected from plastic, ceramic, glass, or inert polymer according to the specific reagent test and the testing requirements of the equipment.
[0037] For a detailed schematic diagram of the solid phase hole structure, please refer to [link / reference]. Figure 2 .
[0038] In a preferred embodiment, the solid phase orifice B is a concave orifice shape, including a reagent solid phase portion B1 and a solid phase orifice positioning handle B2. The reagent solid phase portion B1 is located at the bottom of the inner hole of the solid phase orifice B, and the bottom of the inner hole is not open to the outside. The reagent solid phase portion B1 is used to solidify dry chemical reagents at the bottom of the inner hole. Figure 2 As shown in B1. The solid phase orifice positioning handle B2 is disposed on one side of the solid phase orifice B and extends outward, and is used to position the solid phase orifice B by engaging with the base fixing groove at the corresponding position during reagent card assembly.
[0039] See the example of the structure of the reagent solid phase B1. Figure 3In a cross-sectional view, the reagent solid phase section B1 includes a solid phase hole (B11) and a reagent solid phase surface (B12); the reagent solid phase is on the reagent solid phase surface (B12), and the solid phase hole (B11) is used to hold the liquid sample during the reaction. The solid phase hole (B11) is circular in shape, but those skilled in the art should know that the actual implementation is not limited to a circle, and can also be rectangular, square, elliptical or other irregular shapes, all of which are within the protection scope of this invention.
[0040] See Figure 4 The schematic diagram of reagent card base mechanism A is shown. Reagent card base mechanism A is rectangular in shape and includes an assembly hole A1 and a base fixing groove A2, both being the main functional features of the base. The solid-phase hole component B is placed into the assembly hole A1 according to the direction shown in the diagram. The solid-phase hole component positioning handle B2 engages with the base fixing groove A2, achieving the installation and positioning of the solid-phase hole component B. The example base has 6 assembly holes, numbered 1-6 counterclockwise for hole identification. Figure 5 As shown, in actual use, reagent cards should be assembled as needed based on the number of indicators for the joint inspection items. The order of assembly wells is not required and can be flexibly determined according to the usage requirements.
[0041] This modular reagent card can be freely combined and arranged according to the different numbers of indicators in the joint inspection items, realizing the universal standardization of reagent card devices for different joint inspection items, reducing the types of reagent cards, and thus reducing the types of molds, greatly reducing processing costs.
[0042] This reagent card example uses a 6-indicator combination, but the number of wells in this combination is not limited to 6 and can be increased or decreased depending on the number of indicators to be tested.
[0043] The preferred embodiments of the reagent card base mechanism A and the solid phase orifice B are rectangular and fan-shaped structures. However, this invention is not limited to these shapes and can be modified to other shapes and combinations according to actual needs. For example:
[0044] like Figure 6 The diagram shows an example structure of a three-item test kit assembly, which includes three holes (three holes are empty), a fan-shaped solid phase hole component, and a rectangular kit base mechanism A.
[0045] like Figure 7 The diagram shows an example structure of a five-item test kit assembly, which has five holes (one of which is empty), a fan-shaped solid phase hole component, and a rectangular kit base mechanism A.
[0046] like Figure 8 The diagram shows a modified design of a single-ring, ten-hole reagent card assembly, which includes ten holes in a single-ring layout, a circular solid-phase hole component, and a circular reagent card base mechanism A.
[0047] like Figure 9 The diagram shows a double-ring twelve-well reagent card structure, which has twelve wells with a double-ring layout, a circular solid phase well component, and a circular reagent card base mechanism A.
[0048] Example 2
[0049] This embodiment provides the application of the modular body component metabolism detection reagent card of Embodiment 1 in both dry chemical body component metabolism joint detection projects and dry chemical body component metabolism joint detection projects.
[0050] Through the above description of the embodiments, those skilled in the art can clearly understand that the above embodiments can be implemented by software, or by using software plus necessary general-purpose hardware platforms. Based on this understanding, the technical solutions of the above embodiments can be embodied in the form of a software product, which can be stored in a non-volatile storage medium (such as AD-ROM, USB flash drive, mobile hard drive, etc.), including several instructions to cause a computer device (such as a personal computer, server, or network device, etc.) to execute the methods described in the various embodiments of the present invention.
[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.
Claims
1. A modular body composition metabolism detection reagent card, characterized in that, include: The reagent card base mechanism (A) and a plurality of solid phase orifice components (B) are fixedly arranged side by side at intervals on the upper surface of the reagent card base mechanism (A) by spacers, and are used to carry single test reagent cards including the same or multiple different body component metabolism detection reagents; the upper surface of the plurality of solid phase orifice components (B) is flush with the upper surface of the reagent card base mechanism (A); The plurality of solid phase pores (B) are evenly distributed on the upper surface of the reagent card base mechanism (A) in a equidistant manner; The plurality of solid-phase orifice components (B) are disposed on one side of the upper surface of the reagent card base mechanism (A) rather than in the center; or disposed in the center of the upper surface of the reagent card base mechanism (A), while other components are arranged on both sides of the upper surface; or disposed in two semi-circular arrangements on both sides of the upper surface of the reagent card base mechanism (A), while other components are arranged in the center of the reagent card base mechanism (A). The reagent card base mechanism (A) and the solid phase orifice (B) are made of plastic, ceramic, glass, or inert polymer. The upper surface of the reagent card is defined as the front of the reagent card. If the reagent card is inspected from the front, the reagent card base mechanism (A) and the solid phase orifice (B) are made of transparent or opaque materials. If the reagent card is inspected from the back, the reagent card base mechanism (A) and the solid phase orifice (B) are made of transparent materials. The solid phase orifice (B) is a concave orifice, comprising a reagent solid phase portion (B1) and a solid phase orifice positioning handle (B2). The reagent solid phase portion (B1) is located at the bottom of the inner hole of the solid phase orifice (B), and the bottom of the inner hole is not open to the outside. The reagent solid phase portion (B1) is used to solidify dry chemical reagents at the bottom of the inner hole. The solid phase orifice positioning handle (B2) is located on one side of the solid phase orifice (B) and extends outward. It is used to position the solid phase orifice (B) by engaging with the corresponding base fixing groove during reagent card assembly. The reagent solid phase section (B1) includes a solid phase hole (B11) and a reagent solid phase surface (B12); the reagent is solidified on the reagent solid phase surface (B12), and the solid phase hole (B11) is used to hold the liquid sample during the reaction; The solid phase pore (B11) can be circular, rectangular, square, elliptical, or irregular in shape; The reagent card base mechanism (A) includes an assembly hole (A1) and a base fixing groove (A2). After the solid phase hole component (B) is placed into the assembly hole (A1), the solid phase hole component positioning handle (B2) is engaged in the base fixing groove (A2) to install and position the solid phase hole component (B). The reagent card base mechanism (A) is circular, rectangular, or square in shape.