Detection device, detection system, and detection method

Abstract

The invention provides a detection device, a detection system and a detection method which can improve reliability of detection results while realizing miniaturization and low cost of the device. This detection device is provided with: a container for accommodating a sample to be measured; the bearing mechanism is used for detachably bearing the container; a film coating mechanism which is used for arranging a film covering the interior of the container on the container loaded on the loading mechanism; a sample injection mechanism for injecting the sample into the container covered with the film; and a measurement mechanism that measures the sample in the container.

Description

Technical Field

[0001] The invention relates to a detection device, a detection system and a detection method. Background Art

[0002] Regarding detection devices for detecting samples such as blood and slices, it is generally necessary to prepare empty containers in advance. After the containers are provided to a working area such as a reaction disk by a feeding mechanism, a liquid mixed with the sample and a reagent or the sample is injected into the container as a sample, and the sample is tested by photometry and other tests.

[0003] Taking the blood coagulation device as an example, a liquid mixed with blood and a reagent is injected into a container such as a sample bottle as a sample, so as to perform various tests such as blood coagulation detection. The sample bottle used in the blood coagulation device is difficult to clean due to the coagulation properties of blood, so disposable sample bottles are generally used at present. After the test is completed, the entire sample bottle and the sample in it are discarded together, so that the sample bottle becomes a consumable, resulting in a considerable amount of waste, and also a burden on energy and the environment.

[0004] In addition, during the flow process of automatic testing using a reaction disk, it is necessary to continuously replenish the sample bottles, and the amount of sample bottles used is large, so it is necessary to set up a space for storing the sample bottles in the testing device. The existing blood coagulation device includes a storage unit, a direction adjustment unit, a sorting unit, and a sample bottle picking unit to ensure the correct feeding of the sample bottles. The structure of each unit is relatively complex and the number of components is large, which makes the testing device large-scale and increases the cost.

[0005] Furthermore, when loading the sample bottles into such a detection device, an operator is required to lift the messy sample bottles and dump them into the storage unit, which brings inconvenience to the operator and has the risk of spilling the sample bottles. Summary of the invention

[0006] The present invention has been made in view of the above problems, and an object of the present invention is to provide a detection device, a detection system, and a detection method that can improve the reliability of detection results while achieving miniaturization and cost reduction of the device.

[0007] The present invention is a detection device, which comprises: a container for accommodating a sample to be measured; a carrying mechanism for detachably carrying the container; a coating mechanism for providing a film covering the interior of the container on the container carried on the carrying mechanism; a sample injection mechanism for injecting the sample into the interior of the container covered with the film; and a measuring mechanism for measuring the sample in the container.

[0008] In addition, in the detection device of the above technical solution, the supporting mechanism may also include: a plurality of detachable container holders, the container holders being used to accommodate and support the containers; and a driving unit driving the supporting mechanism to move the plurality of container holders in the same direction.

[0009] Furthermore, in the detection device of the above technical solution, it is also possible to further include a film taking mechanism, and after the measurement of the sample by the measuring mechanism is completed, the film taking mechanism takes out the film from the container.

[0010] In addition, in the detection device of the above technical solution, it may be that the carrying mechanism transports the container in a manner that allows the container to circulate on a circular moving path, and the circular moving path at least includes a coating position where the coating mechanism coats the container, a dispensing position where the sample is injected by the sample injection mechanism, and a film taking position where the film is taken by the film taking mechanism, so that the container is coated again by the coating mechanism after the film is taken by the film taking mechanism.

[0011] In addition, in the detection device of the above technical solution, the film taking mechanism may also include: a packaging part, which packages the film covering the sample after the measuring mechanism completes the measurement of the sample; and a separation part, which separates the packaged film from the container and takes out the film.

[0012] In addition, in the detection device of the above technical solution, the coating mechanism may also include: a film feeding section, which provides the container with a film covering the upper part of the opening of the container; a film cutting section, which cuts the film; a film softening section, which softens and deforms the film covering the upper part of the opening of the container; and a film molding section, which molds the softened film by fitting it to the interior of the container.

[0013] In addition, the present invention can also be a detection system, which includes: a reagent library for storing reagents used to form samples; a detection device as described in the above technical solution; and a control unit for controlling the actions of various parts of the detection device.

[0014] In addition, the present invention can also be a detection method in a detection device, which includes: a loading step, placing a container for accommodating a sample to be measured on a loading mechanism; a coating step, providing a film covering the interior of the container on the container loaded on the loading mechanism; a sample injection step, injecting the sample into the interior of the container covered with the film; and a measuring step, measuring the sample in the container.

[0015] According to the present invention, the container used in the detection device can be reused, so that the storage and transfer mechanisms of the container can be reduced or omitted, the volume of the detection device can be reduced, miniaturization can be achieved, and energy consumption can be reduced. In addition, by reducing the replacement of containers, the labor intensity of operators is reduced. At the same time, the problem of dust caused by friction and electrostatic adsorption dust during the transfer of the container affecting the measurement results is avoided, so that the measurement accuracy and reliability of the detection device can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is an overall schematic diagram of the detection device involved in the first embodiment.

[0017] Figure 2 This is a flowchart of the detection method in the detection device according to the first embodiment.

[0018] Figure 3 It is a cross-sectional view showing a sample bottle in the detection device according to the first embodiment.

[0019] Figure 4 It is a perspective schematic diagram showing a container holder for accommodating a sample bottle in the detection device according to the first embodiment.

[0020] Figure 5 It is a schematic diagram of the structure related to the coating process in the detection device according to the first embodiment.

[0021] Figure 6 1 is a schematic diagram showing the structure of a cutting arm in the detection device according to the first embodiment.

[0022] Figure 7 It is a cross-sectional view showing a cutting arm in the detection device according to the first embodiment.

[0023] Figure 8 It is a perspective schematic diagram showing a container holder to which a film packaging module is mounted in the detection device according to the first embodiment.

[0024] Fig. 9 (a) is a perspective schematic diagram showing a first link of a membrane packaging assembly in a detection device according to a first embodiment, Fig. 9 (b) is a perspective schematic diagram showing the second link of the film packaging assembly in the detection device involved in the first embodiment.

[0025] Fig.10 It is a cross-sectional schematic diagram of the state in which the cutting arm and the container holder are engaged after the coating process is completed in the first embodiment.

[0026] Fig.11 It is a perspective schematic diagram showing a reel around which a film tape is wound in the detection device according to the first embodiment.

[0027] Fig.12 It is a perspective schematic diagram showing a molded film attached to a sample bottle in the detection device according to the first embodiment.

[0028] Fig.13 It is a perspective schematic diagram showing a state of the film packaging assembly in the detection device according to the first embodiment before packaging.

[0029] Fig.14 It is a perspective schematic diagram showing a state in which the film packaging assembly in the detection device according to the first embodiment is packaged.

[0030] Fig.15 1 is a schematic diagram showing an arrangement state of film package modules on a reaction disk in the detection device according to the first embodiment.

[0031] Fig.16 1 is a schematic diagram showing a state after packaging of the molding film according to the first embodiment is completed.

[0032] Fig.17 It is a perspective schematic diagram showing the molded film after packaging in the detection device according to the first embodiment.

[0033] Fig.18 It is a schematic diagram showing a package detection mechanism in the detection device according to the first embodiment.

[0034] Fig.19 Schematic diagram showing the membrane removal assembly in the detection device according to the first embodiment.

[0035] Fig. 20 This is a detailed flowchart of a single photometry detection in the detection device according to the first embodiment.

[0036] Fig.21 It is a schematic diagram of the structure related to the coating process in the detection device according to the second embodiment.

[0037] Fig. 22 It is a perspective schematic diagram showing a push rod in the detection device according to the second embodiment.

[0038] Fig.23 It is a cross-sectional schematic diagram of a state where a cutting arm and a container holder are engaged in a coating process according to a second embodiment.

[0039] Fig.24 It is a cross-sectional schematic diagram of a state where a sealing arm and a container holder are engaged in a coating process according to a third embodiment.

[0040] Fig.25It is a cross-sectional schematic diagram of a state where a sealing arm and a container holder are engaged in a coating process according to a fourth embodiment.

[0041] Fig.26 It is a schematic diagram of the simplified structure of the detection device involved in the fifth embodiment.

[0042] Fig. 27 This is a flowchart of a detection method in the detection device according to the fifth embodiment.

[0043] Description of reference numerals:

[0044] 1...sample bottle; 11...through hole; 2...molding film; 3...movable component; 10...film covering component; 20...film taking component; 30...reaction plate; 40, 203...optical sensor; 50...dispensing component; 60...measuring component; 70...actuator; 101...arm support; 102, 113...cutting arm; 103, 206...air blowing tube; 104...roller; 105...roller support; 106...blade; 107, 307,...heating plate; 108...hollow pipe; 109...film belt; 110, 310...pump; 201... Rack; 202...driving rod; 80, 204...grabbing arm; 205, 308...electromagnet; 301...container holder; 302...detection port; 303...first connecting rod; 304...driving wheel; 305...second connecting rod; 306...driven wheel; 309...suction pipe; 51...light measuring part; 112...push rod; 114...spring; 120, 130...guide pipeline; 121...wire; 122...heater; 131...first passage; 132...second passage; 133...mixing area; 134...discharging port; 310...seal. DETAILED DESCRIPTION

[0045] Hereinafter, a plurality of embodiments of the present invention will be described in detail based on the drawings. In addition, in each embodiment, substantially the same components are denoted by the same reference numerals, and detailed descriptions thereof are appropriately omitted.

[0046] In the description of the embodiment, a blood coagulation device is described as an example of a detection device. However, the present invention is not limited to the blood coagulation device, and the present invention can be applied to any device that performs a test on a subject using a container.

[0047] In addition, the various drawings schematically show structures for the convenience of explanation, and the specific sizes of the parts and the proportional and positional relationships between different parts are not necessarily consistent with the actual products, but have been appropriately deformed.

[0048] (First Embodiment)

[0049] The detection device involved in the first embodiment is a blood coagulation device that automatically performs blood coagulation detection by arranging multiple components in the same housing. For the convenience of description, only the structure related to the improvement of the present invention is extracted for description, and other structures and electrical equipment can use existing components, and the housing of the entire device can also be designed according to space requirements.

[0050] Figure 1 The blood coagulation device as the detection device mainly includes a sample bottle 1 , a film covering assembly 10 , a film removal assembly 20 , a reaction disk 30 , an optical sensor 40 , a dispensing assembly 50 , and a measuring assembly 60 .

[0051] The sample bottle 1 is used to contain a sample to be measured. In this embodiment, the photometric detection of a blood coagulation device is used as an example for explanation. Therefore, in order to be able to perform photometry on the sample contained in the sample bottle 1 from the outside of the sample bottle 1, the sample bottle 1 is a transparent container that can transmit light.

[0052] Figure 3 1 is a cross-sectional view showing a sample bottle 1 in the detection device according to the first embodiment. The sample bottle 1 is a bottomed container with one side open, and has an edge extending outward around the opening. The size and shape of the edge match the container holder 301 on the reaction disk 30 for carrying the sample bottle 1, so that the sample bottle 1 can be accommodated and supported in the container holder 301. A through hole 11 is provided at the bottom of the sample bottle 1. In addition, the shape of the sample bottle 1 is not limited thereto, and any container with one side open can be used, and its cross-sectional shape and appearance can be arbitrarily set according to the supporting mechanism.

[0053] The reaction disk 30 is in the shape of a ring and can be composed of a movable inner ring and a fixed outer ring like the existing reaction disk mechanism. A plurality of container holders 301 arranged in a ring shape are provided on the movable inner ring. The container holders 301 can be detachably mounted on the movable inner ring of the reaction disk 30 for accommodating the sample bottles 1 as containers. Figure 4 FIG. 1 is a perspective view showing a container holder 301 for accommodating a sample bottle 1 in the detection device according to the first embodiment. Figure 4 As shown, the container holder 301 is configured as a square cylinder, with a detection port 302 for a light measuring device to pass through on at least one side, and a step is provided around the upper opening for supporting the edge of the sample bottle 1. The container holder 301 can be detachably mounted on the reaction disk 30, or can be fixed on the reaction disk 30.

[0054] Figure 4The container holder 301 is only an example, and the present invention is not limited thereto. The container holder 301 may also be in other shapes such as a cylinder, as long as it can support the sample bottle 1. In addition, the reaction disk 30 may also support the sample bottle 1 in other ways and omit the container holder 301.

[0055] The reaction disk 30 is connected to a driver 70, and a movable inner ring on which a plurality of container holders 301 are arranged can be driven by the driver 70 to move along the Figure 1 The container holder 301 rotates clockwise in the direction of the arrow in the figure, thereby driving the container holder 301 along the Figure 1 Move in the direction of the arrow.

[0056] The coating assembly 10 is provided at a coating position along the rotation direction of the reaction disk 30 , and a film covering the inside of the sample bottle 1 is provided on the sample bottle 1 placed on the reaction disk 30 passing through the coating assembly 10 . The detailed structure will be described later.

[0057] The optical sensor 40 is arranged downstream of the film coating assembly 10 in the rotation direction of the reaction disk 30, and performs a pre-lighting on the sample bottle 1, and detects whether a film is attached or whether the attached film (hereinafter referred to as a formed film) meets the conditions required for measurement based on the refractive index or light energy of the detected light. In the case where the conditions required for measurement cannot be met, for example, when no film is detected or the film shape is unqualified, the sample bottle 1 is not used for subsequent dispensing processing and the like. The sample bottle 1 can be discarded or the sample bottle 1 can be moved to the next film coating assembly 10 as an empty bottle as the reaction disk 30 rotates to be re-filmed.

[0058] The optical sensor 40 is provided to improve the success rate of measurement. Depending on the specific content of the measurement process and the required success rate, the optical sensor 40 may sometimes be omitted.

[0059] The dispensing assembly 50 is arranged downstream of the optical sensor 40 in the rotation direction of the reaction disk 30, and injects the sample required for measurement into the interior of the sample bottle 1 covered with a membrane. In blood coagulation detection, it is generally necessary to inject blood as a sample and a reagent that can react with the blood into the sample bottle in steps. However, the present invention is not limited to this. In other measuring devices, sometimes only the sample is injected or a mixture of the sample and the reagent is injected. Here, the substances injected into the sample bottle are collectively referred to as samples. The so-called sample can be a sample, or a mixture of a sample and a reagent, or a composite of a sample and a reagent. The dispensing assembly 50 can utilize an existing dispensing mechanism, so that a detailed description is omitted.

[0060] The measuring unit 60 measures the sample after the sample bottle 1 is dispensed. Figure 1The position is set downstream of the dispensing assembly 50 in the rotation direction of the reaction disk 30, but the setting position is not limited to the position according to different detection contents of the detection device. Figure 1 For example, in the blood coagulation device of this embodiment, since the photometry of the sample is used as an example for explanation, the measurement component 60 can also be set on the container holder 301 and move with the container holder 301, as long as it can measure the sample.

[0061] The film removal assembly 20 is disposed upstream of the film coating assembly 10 in the rotation direction of the reaction disk 30 , and takes out the molded film from the sample bottle 1 after the measurement of the sample by the measurement assembly 60 is completed.

[0062] Each of the film covering assembly 10 , the film removing assembly 20 , the optical sensor 40 , the dispensing assembly 50 and the measuring assembly 60 can be provided with one or more components respectively. In this embodiment, one component is provided as an example for description.

[0063] Through Figure 1 In the arrangement shown, an empty sample bottle 1 accommodated in the container holder 301 can pass through the film covering assembly 10, the dispensing assembly 50, and the film removal assembly 20 in sequence to become an empty sample bottle 1 again after completing one measurement, so that the sample bottle 1 can be recycled.

[0064] Figure 2 FIG. 1 is a flow chart of a detection method in a detection device according to a first embodiment. Figure 2 As shown, when starting detection by the detection device, the sample bottles 1 are placed on the container holders 301 on the reaction disk in the preparation stage (step S201), and then the reaction disk 30 is driven to start the automatic detection process (step S202).

[0065] As the reaction disk 30 rotates, the coating assembly 10 coats the inside of the sample bottle 1 moved to the coating position (step S203). The coated sample bottle 1 continues to move to the dispensing position, and the dispensing assembly 50 sequentially injects various samples into the inside of the sample bottle 1 (step S204), and the measuring assembly 60 performs various measurement processes (step S205). After the measurement is completed, the sample bottle 1 is moved to the film removal position, and the film removal assembly 20 takes out the molded film together with the sample therein (step S206), and confirms whether all the measurement tasks to be performed are completed (step S207).

[0066] When all the measurement tasks are completed (step S207: Yes), the operation of the detection device is terminated. When all the measurement tasks are not completed (step S207: No), the process returns to step S202, and the sample bottle 1 after the film is removed returns to the film-coating position as the reaction disk 30 rotates, and the film-coating assembly 10 re-coats the inside of the sample bottle 1 moved to the film-coating position to perform the next measurement task.

[0067] The detailed structures of the film covering assembly 10 and the film removing assembly 20 can be arbitrarily designed according to the type of container used, the requirements and conditions of the measurement task, as long as the functions of covering the inside of the container and removing the film can be achieved. As an example, the following describes in detail the various components of the film covering assembly 10 and the film removing assembly 20 used in this embodiment.

[0068] Figure 5 FIG. 1 is a schematic diagram of the structure related to the coating process in the detection device involved in the first embodiment. Figures 3 to 5 As shown, the coating assembly 10 mainly includes: a reel 104 for feeding a film tape 109 above the sample bottle 1 moved to the coating position, a reel holder 105 for supporting the reel 104, a hollow cutting arm 102 arranged above the film tape 109 and capable of moving up and down, an air blowing pipe 103 connected to the hollow part of the cutting arm 102, a pump 110 for inputting high-pressure gas to the air blowing pipe 103, an arm holder 101 for supporting the cutting arm 102, an air suction pipe 309, an electromagnet 308 for controlling the connection and disconnection between the air suction pipe 309 and the through hole 11 of the sample bottle 1 moved to the coating position, and a pump 310 for sucking air from the air suction pipe 309.

[0069] In addition, Figure 5 The photometric unit 51 is also shown in the detection port 302 provided on the side of the container holder 301. The photometric unit 51 can directly irradiate light into the interior of the sample bottle 1 through the detection port 302 to perform photometry. By directly mounting the photometric unit 51 on the container holder 301, photometry can be performed at any time, so that the photometric unit 51 can be used instead of Figure 1 The optical sensor 40 in the embodiment performs the prediction light for detecting the presence or absence of the film. In this case, the optical sensor 40 is omitted.

[0070] The film tape 109 is a strip-shaped film formed of a transparent resin, and both ends of the strip are respectively wound on two reels 104 , so that the film tape 109 can be transmitted between the pair of reels 104 by driving the pair of reels 104 to rotate in the same direction.

[0071] Figure 6 1 is a schematic diagram showing the structure of the cutting arm 102 in the detection device according to the first embodiment. Figure 7FIG. 1 is a cross-sectional view showing the cutting arm 102 in the detection device according to the first embodiment. Figure 6 , 7 As shown, the cutting arm 102 is integrally formed into a shape in which an upper cylinder is connected to a lower rectangular parallelepiped, a hollow pipe 108 is formed in the middle and passes through the middle, and blades 106 are formed downwardly around the rectangular parallelepiped. In addition, a heating plate 107 having a hole connected to the hollow pipe 108 is formed on the lower surface of the cutting arm 102 facing the film belt 109.

[0072] The blade 106 on the cutting arm 102 is arranged around the lower surface of the cutting arm 102, and is used to cut the film formed in the sample bottle 1 from the film strip 109. In this embodiment, the film can be cut along the outer circumference of the upper surface of the container holder 301. In order to facilitate the removal of the film, a mechanism for separating or packaging the formed film is sometimes installed on the container holder 301, and the blade 106 can be arranged in accordance with various settings on the upper surface of the container holder 301. For example, Figure 8 An example of a vessel holder 301 with a membrane packaging assembly mounted thereon is shown.

[0073] like Figure 8 As shown, a first link 303 and a second link 305 are rotatably provided around the upper opening of the container holder 301 in this embodiment. The shape of the first link 303 is as shown in FIG. Fig. 9 As shown in (a), a U-shape is formed around the container support 301, and a driving wheel 304 is fixed at one end. When the driving wheel 304 rotates, it can drive the first connecting rod 303 to rotate around the rotating axis of the driving wheel 304. The shape of the second connecting rod 305 is as shown in Fig. 9 As shown in (b), a U-shape is formed around the container support 301, and a driven wheel 306 meshing with the driving wheel 304 is fixed at one end. When the driven wheel 306 rotates, the second connecting rod 305 can be driven to rotate around the rotation axis of the driven wheel 306. In addition, one of the first connecting rod 303 and the second connecting rod 305 ( Figure 8 A heating plate 307 is also attached to the upper surface of the first connecting rod 303 (in the middle).

[0074] Figure 8 The sample bottle 1 is placed in the container holder 301. When the container holder 301 moves to the film coating position, the first connecting rod 303 and the second connecting rod 305 are in a state of Figure 8 In the state, the first connecting rod 303 and the second connecting rod 305 surround the opening of the sample bottle 1, and the upper surfaces of the heating plate 307 and the second connecting rod 305, the upper surface of the container holder 301 and the upper surface of the sample bottle 1 are roughly in the same plane.

[0075] When the container holder 301 moves to the film coating position, the container holder 301 moves to the bottom of the film strip 109 so that the film strip 109 covers the container holder 301. Figure 8 The container holder 301 and the upper surface of the heating plate 307 and the second connecting rod 305 shown in the figure. At this time, the cutting arm 102 moves downward to cut the film covering the upper part of the container holder 301 from the film belt 109. In addition, the heating plate 107 heats the film between the container holder 301 and the cutting arm 102 to soften the film. Furthermore, the air blowing pipe 103 blows high-pressure gas into the inside of the sample bottle 1 through the film under the action of the pump 110, so that the softened film bulges into the inside of the sample bottle 1 and deforms. At this time, the electromagnet 308 can be driven to make the air suction pipe 309 rise and connect to the sample bottle 1. The air suction pipe 309 sucks air from the inside of the sample bottle 1, so that the softened film is attached to the inner wall of the sample bottle 1 to form a molded film 2.

[0076] Fig.10 FIG. 1 is a cross-sectional schematic diagram of the cutting arm and the container holder in the first embodiment after the film coating process is completed. Fig.10 As shown, the blade 106 at the lower end of the cutting arm 102 is engaged with the outer periphery of the container holder 301 to cut the film, and the film is deformed by the high-pressure gas and the original gas in the sample bottle 1 is extracted, so that the inside of the sample bottle 1 is formed as shown in FIG. Fig.12 The molding film 2 shown in the figure has a main body in the shape of a container similar to the inner shape of the sample bottle 1, and can contain a liquid sample therein. The opening of the molding film 2 extends outwardly to cover the upper surface of the sample bottle 1, the upper surface of the container holder 301, the heating plate 307 and the upper surface of the second connecting rod.

[0077] In addition, in order to ensure the supply of the film, the formed film 2 may be cut off from the film tape 109 after the formed film 2 is formed. Fig.11 As shown, the opening has a shape corresponding to the cutting line of the blade 106. After the cutting arm 102 is separated from the container holder 301, the cut portion of the film strip 109 can be left from the film covering position and covered with a continuous film above the next container holder 301 by the co-rotation of the pair of reels 104.

[0078] Back to Fig.10 As shown in the figure, through the blowing of high-pressure gas and the suction of the suction pipe 309, the molded film 2 is tightly attached to the inner wall of the sample bottle 1. The inner wall of the sample bottle 1 is preferably smooth to prevent wrinkles when the film is attached. The optical sensor 40 can also be used to detect whether the shape of the formed molded film 2 meets the detection requirements, such as whether there is a missing part of the film. Fig.10FIG. 3 also shows a state where the sample bottle 1 is accommodated in the container holder 301 and the distribution of the heating plate 307 , the first connecting rod 303 and the second connecting rod 305 .

[0079] After the forming film 2 is cut, the cutting arm 102 rises and separates from the container holder 301, and the coated sample bottle 1 continues to rotate with the container holder 301 to other positions for dispensing and testing. Fig.10 A light measuring unit 51 for measuring light of the sample in the sample bottle 1 is provided in the detection port, and light measurement can be performed at any time. In addition, it is preferred that the light measuring unit 51 measures light through the flat surface of the sample bottle 1. According to the principle of vacuum forming, the film will not have wrinkles on the flat surface after forming, so the formed film 2 will not affect the light measurement.

[0080] After the predetermined measurement process is completed, that is, after the use of the sample bottle 1 is finished, the sample bottle 1 moves to the film removal position along with the container holder 301 , and the molded film 2 is removed from the sample bottle 1 by the film removal assembly 20 .

[0081] After the test is completed, the sample bottle 1 often still contains liquid samples. If the molded film is taken out directly, there is a risk of the sample splashing to the outside and causing contamination. Therefore, preferably, the film removal component 20 includes a membrane packaging component for packaging the molded film 2 and a film removal component for separating the packaged molded film 2 from the sample bottle 1 and taking out the molded film 2.

[0082] In this embodiment, the film packaging assembly includes Figure 8 The heating plate 307, the first connecting rod 303, the second connecting rod 305 and the sealing start mechanism provided at the sealing position described in the previous section are provided on the container holder 301. The sealing start mechanism is provided at the sealing position for sealing the molding film 2 on the reaction disk 30. When the sample bottle 1 moves to the sealing position along with the container holder 301, the sealing start mechanism changes the first connecting rod 303 and the second connecting rod 305 from the open state to the closed state. Fig.13 An example of the package activation mechanism is shown in FIG.

[0083] Fig.13 1 is a perspective schematic diagram showing the state of the film packaging assembly in the detection device according to the first embodiment before packaging. Fig.13 As shown, the shaded portion above represents the molding film 2, which covers the heating plate 307, the first connecting rod 303 and the second connecting rod 305, and the driving wheel 304 is engaged with the driven wheel 306. In addition, the packaging start mechanism includes a rack 201 and a driving rod 202 fixedly connected to the rack 201. The rack 201 and the driving rod 202 are arranged at a position corresponding to the packaging position of the reaction disk 30 (for example, a fixed outer ring, not shown in the figure) in a manner that they do not move with the container holder 301, and can move up and down.

[0084] When the container holder 301 that needs to take the film moves to the packaging position, the driving rod 202 rises to drive the rack 201 to the position where it meshes with the driving wheel 304. After the driving wheel 304 meshes with the rack 201, the container holder 301 continues to move so that the driving wheel 304 is on the rack 201. Fig.13 The first connecting rod 303 rotates from left to right in the middle of the driving wheel 304, and as the driving wheel 304 rotates, the first connecting rod 303 rotates around the rotation axis of the driving wheel 304. Fig.13 The driven wheel 306 also rotates, driving the second connecting rod 305 to rotate around the rotation axis of the driven wheel 306. Fig.13 The first connecting rod 303 and the second connecting rod 305 move the edges of the formed film 2 covered thereon to the middle, and the driving wheel 304 just leaves the rack 201. Fig.14 The state shown is that the edges of the molded film 2 are merged together (the driving rod 202 is not shown).

[0085] exist Fig.14 In the state of the first connecting rod 303 and the second connecting rod 305, the first connecting rod 303 and the second connecting rod 305 stand up and clamp the edge of the molding film 2 and the heating plate 307. At this time, the heating plate 307 heats the edge of the molding film 2 to form a seal, thereby sealing the inside of the molding film 2. Thus, the packaging of the molding film 2 is completed.

[0086] Fig.15 The membrane packaging assembly is shown on the reaction plate. Fig.14 When the packaging of the molding film 2 is completed, the driving rod 202 drives the rack 201 to descend, and the container support 301 becomes Fig.16 The molded film 2 is Fig.17 The shape shown stands in the sample bottle 1, and the seal of the encapsulated molded film 2 protrudes from the top of the container holder 301.

[0087] In this embodiment, it is also possible to Fig.18 As shown, a light sensor 203 for detecting whether packaging is completed is provided as a packaging detection mechanism downstream of the packaging start mechanism on the moving route of the container holder 301. Fig.18 2 is a schematic diagram showing a packaging detection mechanism in the detection device according to the first embodiment. The optical sensor 203 irradiates light above the container holder 301 to confirm whether there is a seal of the molded film 2 after packaging above the container holder 301, thereby detecting whether the packaging is completed. The optical sensor 203 can be set on the fixed outer ring of the reaction disk 30. In the case where the optical sensor 203 fails to detect the seal of the molded film 2, the molded film 2 is not removed, and the sample bottle 1 is moved to the next packaging position in an unsealed state as the reaction disk 30 rotates to re-package the molded film 2.

[0088] Fig.19 2 is a schematic diagram showing a film removal assembly in the detection device according to the first embodiment. The film removal assembly includes a gripping arm 204 disposed downstream of the packaging start mechanism on the moving route of the container holder 301, an air blowing pipe 206, and an electromagnet 205 for controlling the connection and disconnection between the air blowing pipe 206 and the through hole 11 of the sample bottle 1 moved to the gripping position of the gripping arm 204.

[0089] When the sample bottle 1 containing the packaged molding film 2 moves to the grabbing position of the grabbing arm 204, the grabbing arm 204 descends to clamp the seal of the packaged molding film and then stretches it upward. At the same time, the electromagnet 205 is driven to make the blowing tube 206 rise and connect with the sample bottle 1. The blowing tube 206 blows air from the bottom of the sample bottle 1 to the inside to promote the separation of the molding film 2 and the inner wall of the sample bottle 1. As a result, the molding film 2 is separated from the inner wall of the sample bottle 1 and detaches from the sample bottle 1 as the grabbing arm 204 rises.

[0090] After the gripping arm 204 grips the molded film 2 from the sample bottle 1, it is transferred to a collection position for waste liquid treatment or discarding of the molded film.

[0091] Furthermore, the electromagnet 205 and the air blowing pipe 206 may be omitted if it is possible to ensure that the molded film 2 is not damaged.

[0092] Through the cooperation of the film covering assembly 10 and the film removing assembly 20 described above, the detection device does not need to replace the sample bottle from the reaction disk each time when performing automatic detection in a cycle, but can reuse the sample bottle. The following describes the process of a single detection process of a sample bottle in this embodiment.

[0093] Fig. 20 Detailed flowchart of the primary photometric detection in the detection device according to the first embodiment. When the container holder 301 carrying the reaction disk 30 and containing the empty sample bottle 1 moves to the right below the cutting arm 102 (step S501), the Figure 5 The sensor not shown in the figure detects whether there is a film strip just below the cutting arm 102 (step S502). When no film strip is detected (step S502: No), the process proceeds to step S509 to perform a pre-illumination on the sample bottle 1 to detect whether there is a molded film inside the sample bottle 1.

[0094] When the film tape is detected (step S502: yes), the cutting arm 102 descends and cuts the film tape (step S503). Then, in step S504, the electromagnet 308 operates to connect the air suction pipe 309 to the sample bottle 1, and the heating plate 307 heats the film (step S505), and the air blowing pipe 103 fills the inside of the sample bottle 1 with gas from above through the film through the hollow pipe 108 of the cutting arm 102, and the air suction pipe 309 extracts the gas in the sample bottle 1 from below (step S506).

[0095] Thus, after the coating is integrally adhered to the inner wall of the sample bottle 1 and the upper surface of the container holder 301 to form a molded film 2, the blowing of the blowing pipe 103 and the suction of the suction pipe 309 are stopped, the cutting arm 102 rises and the container holder 301 continues to move and leaves the coating position (step S507).

[0096] Next, the reel 104 rotates to shift the remaining film strip after cutting (step S508), and the light measuring unit 51 performs pre-lighting on the sample bottle 1 (step S509) to detect whether the molded film 2 is attached to the inside of the sample bottle 1 (step S510).

[0097] If the molded film 2 is not detected, the sample bottle 1 passes through the subsequent dispensing position and other positions as an empty bottle only as the reaction disk 30 rotates (step S510: No). When it moves to the next coating position, the process returns to step S501 and the sample bottle 1 is coated again.

[0098] When the molding film 2 is detected, step S511 is entered, the container holder 301 moves to the dispensing position, and the dispensing component 50 injects the sample into the interior of the molding film 2 in the bonded sample bottle 1, and then injects the reagent into the interior of the molding film 2 (step S512), so that the sample and the reagent react inside the molding film 2 (step S513).

[0099] Next, the process proceeds to step S514, where the measuring assembly 60 performs photometry and other detection tasks. After the photometry is completed, the container holder 301 moves to the sealing position (step S515), and after the sealing of the molding film 2 is completed at the sealing position (step S516), the optical sensor 203 is used to detect whether the molding film 2 has been sealed (step S517). If the sealing is not completed (step S517: No), the sample bottle 1 passes through the subsequent film taking position and other positions as the molding film 2 is not sealed, and when it moves to the next sealing position as it is, it returns to step S515 to re-seal the molding film 2.

[0100] When the sealing is detected to be completed (step S517: Yes), the container holder 301 moves to the film taking position, and the gripper arm 204 takes out the molded film 2 after sealing, so that the sample bottle 1 becomes an empty sample bottle 1 again and can be used for the next detection process.

[0101] According to this embodiment, the container used in the detection device can be reused, so that the storage, transfer and other mechanisms of the container can be reduced or removed, the volume of the detection device is reduced, miniaturization is achieved, and energy consumption is reduced. In addition, by reducing the replacement of containers, the labor intensity of operators is reduced. At the same time, the problem of dust caused by friction and electrostatic adsorption of dust during the transfer of the container affecting the measurement results is avoided, thereby improving the measurement accuracy and reliability of the detection device. In addition, by packaging the used molded film, the sample after the reaction is sealed, reducing pollution to the environment.

[0102] (Modification of the first embodiment)

[0103] In the first embodiment, an example of automatically performing blood coagulation detection in a detection device by recycling containers such as sample bottles is mainly described. However, the present invention is not limited to this. When measuring manually, of course, the configuration of each component can be dispersed and the container can be moved between the components manually. Moreover, the carrying mechanism for carrying the sample bottle is not limited to the structure and movement method of the reaction disk, and can be arbitrarily designed according to the position of each treatment and the process of the detection method.

[0104] Furthermore, the present invention can be implemented by simply modifying an existing detection device by adding a mechanism for coating and a mechanism for removing the film.

[0105] In addition, when a mechanism for detecting an error such as the optical sensor 40 and the optical sensor 203 is provided, a warning mechanism for giving an alarm based on the result of the error detection may also be provided. For example, when it is detected that the film is not packaged after the processing by the packaging unit, the warning mechanism issues a warning sound or the like to the user indicating that an error has occurred, or when it is detected that the film is not covered after the processing by the film coating mechanism, the warning mechanism issues a warning sound or the like to the user indicating that an error has occurred.

[0106] Furthermore, the number of times the warning mechanism issues a warning may be counted, and when the number of warnings exceeds a predetermined threshold, or when the number of warnings within a certain period of time exceeds a predetermined threshold, the detection of the detection device may be stopped, that is, the rotation of the reaction disk 30 may be stopped and maintenance personnel may be called for inspection.

[0107] In addition, a control unit for controlling the actions of various parts of the detection device can also be installed in an external device such as a user terminal, and the control unit, the detection device, and external devices such as a reagent library can be integrated into a detection system. The control unit can be implemented by a CPU (Central Processing Unit) and a program executed by the CPU, or it can be implemented as hardware based on wired logic. The reagent library is used to store various reagents used in the detection process to form a sample.

[0108] In addition, in the first embodiment, the method of removing the film after packaging the formed film attached to the inside of the container using the film removal assembly is described. However, the present invention is not limited to this, and other methods can also be used to remove the film, for example, the sample in the container can be extracted first and then the film can be removed, or the film can be removed by adsorption, etc., or the packaging step can be omitted and the film can be directly removed. In addition, in the detection device that does not require the reuse of the container, the film removal assembly can also be omitted.

[0109] In addition, in order to prevent the film from wrinkling in the sample bottle and affecting the light measurement, the inner edges of the transparent sample bottle can also be rounded.

[0110] In addition, in the first embodiment, the film is formed by blowing high-pressure gas into the sample bottle 1 through the film using the air blowing tube 103. A pressure sensor can also be set in the passage of the air blowing tube 103 to control the film so that it will not be blown apart due to excessive pressure. The pressure sensor can also simultaneously detect whether the formed film 2 after forming has leaked. If there is a leak, the pressure inside the formed film 2 decreases and the value of the pressure sensor changes. The measurement result of the pressure sensor is fed back to the control unit of the control pump 110, which can better control the supply of high-pressure gas. For example, when the pressure sensor detects that the pressure inside the formed film 2 has reached a preset value, the gas supply is stopped through feedback. The pressure sensor can also replace the function of the optical sensor 40.

[0111] In addition, in the first embodiment, the film for coating is continuously provided to the upper part of the sample bottle 1 by the structure of feeding the film tape 109. In this case, a monitoring mechanism such as a sensor for monitoring the number of films that have not been used by the film tape 109, that is, the number of films that can be provided, can also be additionally provided, so as to grasp the use of the fed film at any time. When it is detected that the number of films that can be provided is less than a predetermined first threshold value (for example, only a single digit of the sample bottles 1 are provided for coating), a report indicating that the remaining amount is too small is issued to the user, urging the replacement or additional film tape 109. In addition, when it is detected that the number of films that can be provided is less than a predetermined second threshold value (for example, the remaining film cannot complete the coating of one sample bottle 1), the rotation of the reaction disk 30 or the coating of the sample bottle 1 can be stopped, waiting for the replacement or additional film tape 109.

[0112] Furthermore, in the first embodiment, a transparent sample bottle and a molded film are used because photometry is required, but the present invention is not limited thereto, and the sample bottle or the molded film may be non-transparent.

[0113] (Second Embodiment)

[0114] The following uses the attached Figures 21 to 23 A second embodiment of the present invention will be described.

[0115] The second embodiment differs from the first embodiment in that the coating method is changed. The other structures can refer to or refer to the description of the first embodiment, so only the differences are described in detail.

[0116] Fig.21 FIG. 2 is a schematic diagram of the structure related to the coating process in the detection device according to the second embodiment. Fig.21 As shown, the coating assembly 10 mainly includes: a reel 104 for feeding a film tape 109 above the sample bottle 1 moved to the coating position, a reel holder 105 for supporting the reel 104, a hollow cutting arm 113 provided above the film tape 109 and capable of moving up and down, a push rod 112 capable of moving in the hollow pipe of the cutting arm 113, an arm holder 101 for supporting the cutting arm 102, a spring 114 connecting the cutting arm 113 and the arm holder 101 as a retractable suspension mechanism, an air suction pipe 309, an electromagnet 308 for controlling the connection and disconnection between the air suction pipe 309 and the through hole 11 of the sample bottle 1 moved to the coating position, and a pump 310 for sucking air from the air suction pipe 309.

[0117] The structure of the cutting arm 113 is also as follows Figure 6 , Figure 7As described above, a heating plate 107 having a hole communicating with the hollow pipe 108 is also formed on the lower surface of the cutting arm 113 facing the film strip 109, similar to the cutting arm 102 in the first embodiment.

[0118] In addition, in this embodiment, a spring 114 can also be set between the cutting arm 113 and the arm bracket 101. When the arm bracket 101 moves downward with the cutting arm 113, the cutting arm 113 first contacts the film strip 109 and presses the film strip 109 to the upper surface of the container bracket 301. Then the spring 114 is squeezed, and under the action of the spring force, the film is pressed and sealed, and the film strip 109 is cut at the same time.

[0119] In addition, Fig.21 Also shown is a photometric unit 51 provided in the detection port 302 on the side of the container holder 301 . The photometric unit 51 can directly irradiate light into the inside of the sample bottle 1 through the detection port 302 to perform photometry.

[0120] In this embodiment, when the container holder 301 moves to the film coating position, the container holder 301 moves to the bottom of the film strip 109, so that the film strip 109 covers the Figure 8 The container holder 301 and the upper surface of the heating plate 307 and the second connecting rod 305 are shown. At this time, the cutting arm 113 moves downward to cut the film covering the upper part of the container holder 301 from the film belt 109. In addition, the heating plate 107 heats the film between the container holder 301 and the cutting arm 113 to soften the film.

[0121] Furthermore, the push rod 112 directly pushes along the hollow pipe 108 toward the inside of the sample bottle 1, thereby pushing and extending the softened film into the inside of the sample bottle 1. At the same time, the electromagnet 308 can be driven to make the air suction pipe 309 rise and connect to the sample bottle 1, and the air suction pipe 309 sucks air from the inside of the sample bottle 1, so that the softened film is attached to the inner wall of the sample bottle 1 to form a molded film 2.

[0122] Fig. 22 1 is a perspective schematic diagram showing a push rod in the detection device according to the second embodiment. The shape of the push rod 112 matches the shape of the interior of the sample bottle 1, and the push rod 112 is set so that when the push rod 112 is pushed into the interior of the sample bottle 1, there is a gap between the push rod 112 and the inner wall of the sample bottle 1 that can be filled with a film.

[0123] In addition, in this embodiment, since the film is stretched and shaped directly by the push rod 112, auxiliary molding structures such as the electromagnet 308 and the suction pipe 309 can also be omitted.

[0124] Fig.23FIG. 2 is a cross-sectional schematic diagram of a state in which a cutting arm and a container holder are engaged in a coating process according to a second embodiment. Fig.23 As shown, the blade 106 at the lower end of the cutting arm 113 is engaged with the outer periphery of the container holder 301 to cut the film, and the push rod 112 is pressed into the interior of the sample bottle 1 to directly stretch and shape the softened film so that the film is between the push rod 112 and the inner wall of the sample bottle 1, thereby forming a film inside the sample bottle 1. Fig.12 The formed film 2 is shown.

[0125] After the forming film 2 is formed, the cutting arm 113 and the push rod 112 rise and separate from the container holder 301 , and the coated sample bottle 1 continues to rotate with the container holder 301 to other positions for dispensing and testing.

[0126] According to this embodiment, the same technical effects as those of the first embodiment described above can be obtained. In addition, by molding the film using the push rod 112, the accuracy of forming the molded film 2 can be improved.

[0127] (Third Embodiment)

[0128] The following uses the attached Fig.24 A third embodiment of the present invention will be described.

[0129] The third embodiment is different from the first embodiment in that the coating method is changed, and the molded film is formed by melting the wire material composed of transparent resin. The other structures can be referred to or referred to the description of the first embodiment, so only the differences are described in detail.

[0130] Fig.24 FIG. 2 is a cross-sectional schematic diagram of a state where the sealing arm and the container holder are engaged in the coating process according to the third embodiment. Fig.24 As shown, the first embodiment Fig.10 The difference is that the roll 104 for feeding the film tape 109 and the roll holder 105 for supporting the roll 104 are omitted. In addition, the cutting arm 113 is replaced with a hollow sealing arm 113 that can move up and down.

[0131] The coating assembly in this embodiment mainly includes: a hollow sealing arm 113, a guide pipe 120 passing through the hollow part of the sealing arm 113, a wire feeding mechanism (not shown) for feeding the wire 121 into the guide pipe 120, and a heater 122 arranged at the front end of the guide pipe 120.

[0132] Specifically, the lower surface of the sealing arm 113 does not have a blade, but instead has a sealing member 310 capable of sealing the gap between the sealing arm 113 and the upper surface of the container holder 30 when the sealing arm 113 is lowered to be close to the upper surface of the container holder 30. The sealing member 310 may be a sealing band provided on the sealing arm 113 and surrounding the lower edge of the sealing arm 113. In addition, the sealing member 310 may be provided separately, and after the sealing arm 113 is lowered to be close to the upper surface of the container holder 30, the sealing member 310 may be installed between the sealing arm 113 and the container holder 30 using an additional mechanism.

[0133] A tubular guide pipe 120 is passed through the hollow portion of the sealing arm 113. A heater 122 is provided at the front end of the guide pipe 120, and a wire 121 made of a melt-deformable transparent resin is inserted into the center tube of the guide pipe 120. The wire 121 is provided to the guide pipe 120 by an external wire feeding mechanism (not shown).

[0134] The outer shape of the guide tube 120 matches the inner shape of the sample bottle 1 , and the outer shape of the guide tube 120 is set so that a gap capable of being filled with a film exists between the guide tube 120 and the inner wall of the sample bottle 1 when the guide tube 120 enters the sample bottle 1 .

[0135] In addition, in the present embodiment, the sample bottle 1 does not have a through hole at the bottom, and the sample bottle 1 may be used after the through hole at the bottom is sealed by the sealing member 310 , thereby eliminating the need for structures related to the suction pipe.

[0136] In this embodiment, when the container holder 301 moves to the film coating position, the sealing arm 113 is lowered to close the gap between the sealing arm 113 and the upper surface of the container holder 30. Fig.24 As shown, the guide tube 120 having the wire 121 passing through it passes through the hollow part of the sealing arm 113 and gradually reaches the bottom of the sample bottle 1. In the process of the guide tube 120 moving downward, the heater 122 heats the wire 121 to melt it, and the melted transparent resin material is squeezed and moves along the guide tube 120 under the pushing action of the guide tube 120 moving toward the bottom of the sample bottle 1. Fig.24 The liquid overflows from the gap between the guide pipe 120 and the bottom wall of the sample bottle 1 to the gap between the guide pipe 120 and the inner wall of the sample bottle 1 in the direction of the arrow, and then overflows into the gap between the closed sealing arm 113 and the upper surface of the container holder 30, thereby forming a molded film 2.

[0137] In order to ensure the supply of resin material, the wire 121 needs to be continuously supplied during the formation of the molding film 2. A barb structure (not shown) can also be provided on the feeding path of the wire 121 to prevent the wire 121 from reversing so that the wire will not break when heated.

[0138] According to this embodiment, the same technical effects as those of the first embodiment described above can be obtained. In addition, the film is formed by feeding the wire material, which can reduce the number of parts of the film coating assembly.

[0139] (Fourth Embodiment)

[0140] The following uses the attached Fig.25 A fourth embodiment of the present invention will be described.

[0141] The fourth embodiment is different from the third embodiment in that the coating method is changed, and a transparent resin liquid is directly injected into the container through a liquid passage to form a molded film instead of using a solid wire. Other structures can refer to or refer to the description of the third embodiment, so only the differences are described in detail.

[0142] Fig.25 FIG. 4 is a cross-sectional schematic diagram of a state where the sealing arm and the container holder are engaged in the coating process according to the fourth embodiment. Fig.25 As shown in the third embodiment Fig.24 In comparison, the difference is that a guide line 130 is provided instead of the guide line 120 .

[0143] The coating assembly in this embodiment mainly includes: a hollow sealing arm 113, a guide pipe 130 that passes through the hollow part of the sealing arm 113, a first passage 131 arranged in the guide pipe 130 to provide liquid transparent resin to the interior of the sample bottle 1, a second passage 132 arranged in the guide pipe 130 to provide a curing agent capable of curing the liquid transparent resin to the interior of the sample bottle 1, and a mixing area 133 arranged in the guide pipe 130 and respectively connecting the first passage 131 and the second passage 132.

[0144] The outer shape of the guide tube 130 matches the inner shape of the sample bottle 1 , and the outer shape of the guide tube 130 is set so that a gap capable of being filled with a film exists between the guide tube 130 and the inner wall of the sample bottle 1 when the guide tube 130 enters the sample bottle 1 .

[0145] In this embodiment, when the container holder 301 moves to the film coating position, the sealing arm 113 is lowered to close the gap between the sealing arm 113 and the upper surface of the container holder 30. Fig.25As shown, the guide pipe 130 passes through the hollow part of the sealing arm 113 and gradually reaches the bottom of the sample bottle 1. In the process of the guide pipe 130 moving downward, a liquid transparent resin is input into the first passage 131 by a conveying mechanism such as a high-pressure pump, and a curing agent for the transparent resin is input into the second passage 132 independent of the first passage 131 by another conveying mechanism. The liquid transparent resin and the curing agent flow into the mixing area 133 connected to the first passage 131 and the second passage 132 along the first passage 131 and the second passage 132 respectively, and are mixed in the mixing area 133. The mixed liquid is ejected from the discharge port 134 connecting the mixing area 133 and the outside, and is squeezed and discharged along the discharge port 134 under the pushing action of the guide pipe 130 moving toward the bottom of the sample bottle 1. Fig.25 The liquid overflows from the gap between the guide pipe 130 and the bottom wall of the sample bottle 1 to the gap between the guide pipe 130 and the inner wall of the sample bottle 1 in the direction of the arrow, and then overflows into the gap between the closed sealing arm 113 and the upper surface of the container holder 30, thereby forming a molded film 2.

[0146] According to this embodiment, it is also possible to obtain the same technical effects as those of the first and third embodiments described above.

[0147] (Fifth Embodiment)

[0148] The following uses the attached Figures 26-27 A fifth embodiment of the present invention will be described.

[0149] The fifth embodiment is different from the first embodiment in that the sample bottle 1 is not coated or removed when it is carried on the reaction disk, but is moved outside the reaction disk for coating or removal. Other structures can refer to or refer to the description of the first embodiment, so only the differences are described in detail.

[0150] Fig.26 In the fifth embodiment, a coating position or a film removal position is not provided on the rotation path of the reaction disk 30, but a grabbing arm 80 capable of grabbing the sample bottle 1 (or the movable component 3 including the sample bottle 1) carried on the reaction disk 30 is provided.

[0151] For example, Fig.26 In that way, a coating mechanism capable of coating an empty sample bottle 1 disposed in the movable component 3 individually using the coating method described in the first to fourth embodiments is disposed outside the reaction disk 30 and after the sample bottle 1 is coated by such a coating mechanism, the movable component 3 including the coated sample bottle 1 is placed on the reaction disk 30 using the grabbing arm 80 for dispensing and detection processing.

[0152] In addition, as described in the first embodiment, a sealing mechanism may be provided on the rotation path of the reaction disk 30, and after sealing the molded film 2 in the sample bottle 1 that has been used in the detection process, the sample bottle 1 that has been sealed is taken out by the grab arm 80, so that contamination of the sample can be prevented. In this case, after the measurement process of the detection device is completed and the molded film 2 is sealed, the sample bottle 1 that has been sealed is taken out from the reaction disk 30 by the grab arm 80, and is moved to the film taking mechanism that can take the film from the sample bottle 1 alone by the film taking method described in the first to fourth embodiments, and the sample bottle 1 that has been taken out is coated again by the coating mechanism, and the sample bottle 1 (or the movable component 3) that has been coated again is put back on the reaction disk 30 by the grab arm 80. In this way, the sample bottle 1 is reused.

[0153] Fig. 27 FIG. 5 is a flow chart of a detection method in a detection device according to a fifth embodiment. Fig. 27 As shown, when the detection device starts to be used for detection, the inside of the sample bottle 1 is coated at the coating mechanism (step S271). After coating, the grab arm 80 places the coated sample bottle 1 on each container holder on the reaction disk (step S272), and then drives the reaction disk 30 to rotate (step S273).

[0154] As the reaction disk 30 rotates, the coated sample bottle 1 moves to the dispensing position, various samples are injected into the sample bottle 1 (step S274), and various measurement processes are performed (step S275). After the measurement, the sample bottle 1 is moved to the film sealing position for packaging (step S276), and the packaged sample bottle 1 moves to the grabbing position, and the grabbing arm 80 grabs the sample bottle 1 at the grabbing position to the film taking mechanism for film taking (step S277).

[0155] Next, it is confirmed whether all the measurement tasks to be performed are completed (step S278). If all the measurement tasks are completed (step S278: yes), the operation of the detection device is terminated. If all the measurement tasks are not completed (step S278: no), it returns to step S271 and continues the laminating of the laminating mechanism to perform the next measurement task.

[0156] In the present embodiment, as described above, the sample bottle 1 can be directly taken out or put into the container holder 30 on the reaction disk 30 by the grasping arm 80, or the movable unit 3 including the sample bottle 1 can be taken out or put into the reaction disk 30 by the grasping arm 80. The movable unit 3 is a unit that can accommodate the sample bottle 1 and can be moved independently, such as the container holder 30. Therefore, the sample bottle 1 can be replaced by the movable unit 3 including the sample bottle 1 and taken out or put into the reaction disk 30 by the grasping arm 80.

[0157] In addition, it is also possible to configure that the sealing mechanism is not provided on the rotation path of the reaction disk 30, but a film taking mechanism with a sealing function is provided outside the reaction disk 30. In this case, the unsealed sample bottle 1 is directly grasped by the grasping arm 80 and moved to the film taking mechanism with a sealing function, and the molded film is sealed and taken.

[0158] For example, in the shape of the formed film Fig.12 In the case as shown in the molded film 2, the film removal mechanism with a sealing function has, for example, a clamp that can be inserted between the sample bottle 1 and the molded film 2 from the outside while clamping the sample bottle 1 so that the edge of the molded film 2 is lifted from the sample bottle 1, and the molded film 2 is sealed by sealing the lifted edge.

[0159] According to this embodiment, the same technical effect as the first embodiment described above can be obtained. In addition, by additionally providing a film coating mechanism or a film removal mechanism, it is avoided to provide complex components related to film coating, packaging, film removal, etc. at various positions on the reaction disk, and it is easier to modify the existing detection device, thereby simplifying the structure of the reaction disk and saving costs.

[0160] Several embodiments of the present invention have been described above, but these embodiments are presented as examples and are not intended to limit the scope of the invention. These new embodiments can be implemented in various other ways, and various omissions, substitutions and changes can be made without departing from the scope of the invention. These embodiments or their variations are included in the scope or spirit of the invention, and are also included in the invention recorded in the claims and the scope of their equivalents.

Claims

1. A detection device, characterized in that: have: A container for containing a sample to be measured; A carrying mechanism for detachably carrying the container; a film covering mechanism for providing a film covering the interior of the container to the container placed on the carrier mechanism; a sample injection mechanism for injecting the sample into the interior of the container covered with the film; as well as The measuring mechanism measures the sample in the container.

2. The detection device according to claim 1, characterized in that: The supporting mechanism comprises: A plurality of detachable container supports, wherein the container supports are used to receive and support the containers; The driving unit drives the carrying mechanism to move the plurality of container supports in the same direction.

3. The detection device according to claim 1, characterized in that: The film is composed of a transparent resin.

4. The detection device according to claim 1, characterized in that: The device further comprises a film taking mechanism for taking out the film from the container after the measurement of the sample by the measurement mechanism is completed.

5. The detection device according to claim 4, characterized in that: The carrying mechanism transports the container in a manner that allows the container to circulate on a circular moving path, and the circular moving path at least includes a coating position for coating by the coating mechanism, a dispensing position for injecting a sample by the sample injection mechanism, and a film taking position for taking a film by the film taking mechanism, so that the container is coated again by the coating mechanism after being filmed by the film taking mechanism.

6. The detection device according to claim 4, characterized in that: It also has a storage mechanism for taking out or putting in the container placed on the carrying mechanism. The storage mechanism places the container coated by the coating mechanism into the carrying mechanism. The sample injection mechanism performs dispensing and the measurement mechanism performs measurement in a state where the container is carried by the carrying mechanism. The storage mechanism takes out the container after measurement from the carrying mechanism.

7. The detection device according to claim 4, characterized in that: The film taking mechanism comprises: a sealing unit that seals the film covering the sample after the measurement of the sample by the measuring mechanism is completed; and The separation unit separates the packaged film from the container to take out the film.

8. The detection device according to claim 7, characterized in that: The packaging unit includes: a packaging support member, which is disposed on the carrying mechanism and moves with the container, supports the opening of the film formed into a container shape inside the container in an open state, and closes the opening of the formed film in a closed state; and The sealing heating unit heats the closed opening of the film to seal the inside of the film.

9. The detection device according to claim 8, characterized in that: The packaging unit further includes: The starting mechanism is arranged at a packaging position on the carrying mechanism for packaging the film. When the container moves to the packaging position, the starting mechanism causes the packaging support to change from the open state to the closed state.

10. The detection device according to claim 4, characterized in that: The device further comprises a sealing detection mechanism for detecting whether the sealing of the film by the sealing section is completed. Before the sealing detection mechanism detects that the sealing of the film is completed, the film is not taken out.

11. The detection device according to claim 10, characterized in that: The invention further comprises a warning mechanism for issuing a warning indicating that an error has occurred when the sealing detection mechanism detects that the sealing of the film is not completed after the processing by the sealing unit.

12. The detection device according to claim 1, characterized in that: The device further comprises a film detection mechanism for detecting whether the interior of the container is covered with a film or the shape of the film, and does not perform injection of the sample until the film is detected to be covered.

13. The detection device according to claim 12, characterized in that: The device further includes a warning mechanism for issuing a warning indicating that an error has occurred when the film detection mechanism detects that the film is not coated after being processed by the film coating mechanism.

14. The detection device according to claim 11 or 13, characterized in that: When the number of times the warning is issued by the warning mechanism exceeds a predetermined threshold, the detection by the detection device is stopped.

15. The detection device according to claim 1, characterized in that: The laminating mechanism comprises: a film feeding section, providing a film covering an opening of the container to the container; A film cutting section for cutting the film; A film softening portion, which softens and deforms the film covering the opening of the container; as well as The film forming unit forms the softened film by bonding it to the inside of the container.

16. The detection device according to claim 15, characterized in that: The film feeding unit further includes a monitoring device for monitoring the amount of film that can be supplied by the film feeding unit and issuing a report indicating that the remaining amount is too small when the amount of film that can be supplied is less than a predetermined first threshold value.

17. The detection device according to claim 16, characterized in that: When the number of films that can be provided is less than a prescribed second threshold, the detection of the detection device is stopped, and the second threshold is smaller than the first threshold.

18. The detection device according to claim 15, characterized in that: The film forming unit comprises: an air blowing unit, disposed above the opening of the container, for blowing air toward the bottom of the container through the film; and The air suction unit is arranged at the bottom of the container and is used for sucking air from the inside of the container.

19. The detection device according to claim 15, characterized in that: The film forming unit comprises: The push rod has a shape that matches the interior of the container and can be pressed into the container through the film.

20. The detection device according to claim 1, characterized in that: The laminating mechanism comprises: A wire feeding portion, providing the container with a wire capable of melting and deforming; a heating unit for heating the wire material to melt the wire material inside the container; as well as The extrusion unit extrudes and deforms the melted wire material to form a film that is bonded to the inside of the container.

21. The detection device according to claim 1, characterized in that: The laminating mechanism comprises: A liquid supply unit for supplying a liquid film-forming material to the container; a curing agent supplying unit for supplying a curing agent for curing the film-forming material to the container; A mixing area for mixing the film-forming material and the curing agent inside the container; as well as The extrusion unit squeezes and deforms the mixed liquid to form a film that adheres to the inside of the container.

22. The detection device according to claim 1, characterized in that: The bottom of the container is provided with a through hole.

23. The detection device according to claim 1, characterized in that: The detection device is a blood coagulation device.

24. A detection system, characterized in that: include: A reagent storehouse, storing reagents used to form test materials; The detection device according to any one of claims 1 to 23; as well as The control unit controls the actions of various parts of the detection device.

25. A detection method in a detection device, characterized in that: include: a loading step of loading a container for accommodating a sample to be measured on a loading mechanism; a coating step of providing a film covering the interior of the container on the container placed on the carrier mechanism; a sample injection step of injecting the sample into the interior of the container covered with the film; as well as The measuring step measures the sample in the container.

Images