Polygonatum sibiricum and ginseng peptide tablet as well as preparation method and application thereof

Abstract

The invention provides a rhizoma polygonati and ginseng peptide tablet and a preparation method and application thereof, and the rhizoma polygonati and ginseng peptide tablet comprises the following raw materials: rhizoma polygonati, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblic leafflower fruit and magnesium stearate. By adopting the raw materials, the rhizoma polygonati and ginseng peptide tablet disclosed by the invention can have very good effects of tonifying qi and yin and tonifying kidney and spleen, so that the problem of deficiency of kidney essence of a human body can be improved.

Description

Technical Field

[0001] The present invention relates to the technical field of preparations, and in particular to a polygonatum ginseng peptide tablet. The present invention also relates to a preparation method of the polygonatum ginseng peptide tablet. At the same time, the present invention also relates to an application of the polygonatum ginseng peptide tablet. Background Art

[0002] Kidney deficiency is a term in traditional Chinese medicine, which refers to the deficiency of kidney essence, yin and yang. There are many types of kidney deficiency, each with different symptoms. Many people will have symptoms of kidney deficiency. Kidney deficiency makes people age quickly and is one of the important causes of aging. Kidney qi has the function of promoting the normal function of various organs. Kidney qi deficiency can cause dysfunction of the heart, liver, gallbladder, spleen, stomach and other organs, and induce pathological factors such as wind, fire, phlegm, and blood stasis. The two interact with each other in the blood vessels, leading to the disorder of the body's qi, blood, body fluids, imbalance of supply and demand, and disorder of qi and blood. Therefore, it is necessary to develop a product that can replenish qi and nourish yin, benefit the kidney and strengthen the spleen. Summary of the invention

[0003] In view of this, the present invention aims to provide a polygonatum ginseng peptide tablet to improve the problem of kidney essence deficiency in the human body.

[0004] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0005] A polygonatum ginseng peptide tablet, wherein the raw materials for preparing the polygonatum ginseng peptide tablet include: polygonatum ginseng, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblica fruit and magnesium stearate.

[0006] Furthermore, the weight proportions of each of the raw materials are respectively: 25 to 40 parts of polygonatum, 30 to 40 parts of wheat oligopeptides, 16 to 28 parts of sorbitol, 4 to 10 parts of ginseng, 0.1 to 0.2 parts of ginseng peptide, 1 to 2 parts of emblica, and 1 to 2 parts of magnesium stearate.

[0007] Compared with the prior art, the present invention has the following advantages:

[0008] The Polygonatum sibiricum and ginseng peptide tablets of the present invention adopt a specific ratio of Polygonatum sibiricum and ginseng, and cooperate with wheat oligopeptides, emblica fruit, etc., so that the Polygonatum sibiricum and ginseng peptide tablets of the present invention have significant effects of replenishing qi and nourishing yin, invigorating the kidney and strengthening the spleen, thereby improving the problem of kidney essence deficiency in the human body.

[0009] In the formula of the polygonatum ginseng peptide tablet of the present invention, polygonatum ginseng is sweet in taste and neutral in nature. It enters the spleen, lung and kidney meridians and has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs and benefiting the kidneys. It is also used for spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, dry cough due to lung deficiency, hemoptysis due to fatigue, insufficient essence and blood, soreness of waist and knees, premature graying of hair and beard, internal heat and thirst, and the like.

[0010] Wheat oligopeptides can promote the enhancement of skeletal muscle SOD activity, accelerate the removal of free radicals, effectively protect cells from sports damage, and effectively maintain the body's athletic ability. At the same time, wheat oligopeptides themselves have antioxidant activity and strong reducing ability, and can directly combine with free radicals to fight free radical damage. In addition, wheat oligopeptides can protect the normal functioning of the spleen and stomach while promoting the absorption of nutrients.

[0011] Sorbitol has multiple functions such as excipient, adhesive, hygroscopicity, etc. It can be used as a binder, disintegrant and filler for direct tableting, and is widely used in the preparation of chewable tablets, laminated tablets, sugar-coated tablets and film-coated tablets. In addition, sorbitol has a sweet taste, which can effectively improve the taste of the product and enhance the comfort of taking it.

[0012] Ginseng tastes sweet, slightly bitter, and slightly warm. It enters the spleen, lung, heart, and kidney meridians. It has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, replenishing spleen and lung, promoting body fluid and nourishing blood, calming the mind and improving intelligence. It is often used to treat symptoms such as physical weakness and fainting, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and coughing, thirst due to loss of body fluid, internal heat and thirst, qi and blood deficiency, long-term illness and weakness, palpitations and insomnia, impotence and cold uterus.

[0013] Ginseng peptide is an active polypeptide substance extracted from ginseng, rich in superoxide dismutase, glutathione peroxidase and other antioxidants. It can not only inhibit platelet aggregation, improve blood fluidity, and reduce the risk of thrombosis, but also stimulate gastric acid secretion, thereby promoting digestion and absorption. On the basis of protecting the spleen and stomach, it can further improve the body's intake and utilization efficiency of nutrients.

[0014] Phyllanthus emblica tastes sweet, sour, astringent and cool in nature. It enters the lung and stomach meridians. It has the effects of clearing heat and cooling blood, promoting digestion and strengthening the stomach, promoting body fluid and relieving cough. It can be used to improve and treat symptoms such as blood heat and blood stasis, indigestion, abdominal distension, cough, sore throat, and dry mouth. At the same time, while Phyllanthus emblica has the function of strengthening the spleen and stomach, it also helps to promote digestion and absorption, and cooperates with other ingredients to maintain the healthy balance of the human digestive system.

[0015] Magnesium stearate is mainly used as a glidant in the preparation process. It can effectively improve the fluidity of the material, ensure that the material can flow and fill evenly and smoothly in production processes such as tableting, and ensure the product molding quality and production efficiency.

[0016] Both Polygonatum and Ginseng belong to the kidney meridian, and both have the effects of replenishing qi and nourishing yin, tonifying the kidney and strengthening the spleen. Wheat oligopeptides, ginseng peptides, and Phyllanthus emblica can promote the absorption of various nutrients by the human body while playing a role in protecting the spleen and stomach. In the Polygonatum ginseng peptide tablets of the present invention, the various raw materials cooperate with each other, so that the prepared Polygonatum ginseng peptide tablets show relatively excellent effects in replenishing qi and nourishing yin, tonifying the kidney and strengthening the spleen, thereby effectively improving the problem of kidney essence deficiency in the human body.

[0017] Another object of the present invention is to provide a method for preparing a polygonatum ginseng peptide tablet, the preparation method comprising:

[0018] Weigh polygonatum, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblica fruit and magnesium stearate according to weight parts;

[0019] The weighed wheat oligopeptide is evenly divided into two portions, one portion of the wheat oligopeptide is taken and mixed with the weighed sorbitol, the ginseng powder, the ginseng peptide powder and the emblica fruit to obtain a first mixed powder; the other portion of the wheat oligopeptide is evenly mixed with the weighed polygonatum to obtain a second mixed powder;

[0020] Forming the first mixed powder and the second mixed powder into uniform first wet granules and second wet granules respectively;

[0021] Drying the first wet granules and the second wet granules respectively to obtain dried first premixed granules and second premixed granules;

[0022] Mixing the first premixed granules and the second premixed granules with magnesium stearate to obtain a total mixed powder;

[0023] The total mixed powder is tableted according to a preset weight to prepare polygonatum ginseng peptide tablets.

[0024] Furthermore, the binder used to prepare the first wet granules is 90% ethanol; and / or the binder used to prepare the second wet granules is 95% ethanol.

[0025] Furthermore, the moisture content of the first premixed particles after drying and / or the second premixed particles after drying is not greater than 7.5%.

[0026] Furthermore, the preset weight is 0.55 g / tablet, and the weight difference limit requirement is ±5%.

[0027] Furthermore, the first wet particles and the second wet particles have different drying temperatures.

[0028] Furthermore, the particle size of the first premixed particles is not larger than 20 meshes; and / or the particle size of the second premixed particles is not larger than 20 meshes.

[0029] Compared with the prior art, the present invention has the following advantages:

[0030] The preparation method of the polygonatum ginseng peptide tablets of the present invention comprises accurately weighing polygonatum ginseng, wheat oligopeptides, sorbitol, ginseng, ginseng peptides, emblica and magnesium stearate according to specific weight portions, which can ensure that the proportions of the components are accurate and the content of the effective components of the final product is stable, thereby ensuring that the polygonatum ginseng peptide tablets have stable and expected effects of replenishing qi and nourishing yin, tonifying the kidney and strengthening the spleen, and maintaining the consistency and reliability of product quality.

[0031] In the mixing step, the wheat oligopeptide is divided into two parts and mixed with other raw materials respectively, which is conducive to the uniform dispersion and preliminary fusion of different raw materials. Among them, one part of wheat oligopeptide is mixed with sorbitol, ginseng powder, ginseng peptide powder, and emblica, which can make the ingredients with antioxidant and absorption-promoting functions fully contact first, which is conducive to the formation of a uniform first mixed powder in the subsequent granulation process, ensuring that the functional ingredients in the product are evenly distributed, so that the efficacy of each piece of product can be stably exerted. Another part of wheat oligopeptide is mixed with Polygonatum sibiricum to form a second mixed powder. Considering the characteristics of Polygonatum sibiricum, it can be better combined with wheat oligopeptide, laying the foundation for the synergistic effect of subsequent processing and the efficacy of the final product.

[0032] In the wet granulation step, 90% ethanol is used as a binder for the first wet granules and 95% ethanol is used as a binder for the second wet granules. Different concentrations of ethanol can adjust the formability and viscosity of the granules according to the characteristics of different raw material combinations. The appropriate binder concentration can make the raw material powders better bond together to form granules, ensure the integrity and strength of the granules, and facilitate subsequent drying, mixing and other operations. At the same time, it will not affect other properties such as solubility due to excessive viscosity, which is conducive to the disintegration of the product in the body and the release of active ingredients.

[0033] In the drying step of the wet granules, the moisture content of the first premixed granules and the second premixed granules after drying is controlled to be no more than 7.5%, which can prevent the granules from becoming moldy and deteriorating due to excessive moisture content, thereby extending the shelf life of the product. The appropriate moisture content is also conducive to the subsequent mixing with magnesium stearate and tableting operations, ensuring the stability and molding quality of the product.

[0034] In the step of mixing the premixed particles with magnesium stearate, magnesium stearate is used as a glidant, and after being mixed with the first premixed particles and the second premixed particles, the fluidity of the particles can be significantly improved. During the tableting process, the material can be evenly filled into the mold, which is conducive to ensuring that each piece of Polygonatum ginseng peptide tablet is tableted according to a preset weight, which is conducive to meeting the quality standard requirements, and is also conducive to improving the tableting efficiency and the integrity and aesthetics of the tablet shape.

[0035] When tableting, the tablets are pressed according to the preset weight, which can accurately control the specifications and dosage of the product, making it convenient for consumers to take it according to the prescribed dosage, ensuring the effectiveness and safety of the product, and enabling the Polygonatum ginseng peptide tablets to play a regulatory role on human health according to the expected efficacy and mode of action, such as improving problems such as kidney essence deficiency.

[0036] In addition, different drying temperatures are set for the first wet granules and the second wet granules, taking into account the possible differences in thermal sensitivity and drying characteristics of different raw material combinations. This can maximize the retention of the effective ingredients and activity of each raw material while ensuring the drying effect of the granules, avoiding the inactivation of certain ingredients due to excessively high temperatures, thereby ensuring that the quality and efficacy of the Polygonatum ginseng peptide tablets are not affected.

[0037] In addition, the particle size of the first premixed granules and the second premixed granules is controlled to be no larger than 20 meshes, and the appropriate particle size is beneficial to the fluidity, mixing uniformity and tableting operation of the granules. Smaller and uniform particle sizes can make the granules easier to mix when mixed with magnesium stearate, and can be more closely arranged and formed during tableting, thereby improving the density uniformity and tablet quality of the product and ensuring the stability of the product during storage, transportation and administration.

[0038] Another object of the present invention is to provide an application of the above-mentioned Polygonatum ginseng peptide tablets, which are used to prepare foods for improving kidney essence deficiency, health foods or special diets.

[0039] In the present invention, the polygonatum ginseng peptide tablets are used in the preparation of foods for improving kidney essence deficiency, health foods or special diets, so that the prepared foods for improving kidney essence deficiency, health foods and special diets have significant effects of replenishing qi and nourishing yin, benefiting the kidney and strengthening the spleen, thereby improving the problem of kidney essence deficiency in the human body. DETAILED DESCRIPTION

[0040] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0041] The present invention will be described in detail below with reference to examples.

[0042] This embodiment relates to a polygonatum ginseng peptide tablet, which can improve the problem of kidney essence deficiency in the human body.

[0043] In terms of overall design, the raw materials for preparing the polygonatum ginseng peptide tablets of this embodiment include polygonatum ginseng, wheat oligopeptides, sorbitol, ginseng, ginseng peptides, emblica and magnesium stearate.

[0044] As a preferred implementation of this embodiment, in the formula of the Polygonatum ginseng peptide tablets of this embodiment, the weight portions of each preparation raw material are respectively: 25 to 40 parts of Polygonatum sibiricum, 30 to 40 parts of wheat oligopeptides, 16 to 28 parts of sorbitol, 4 to 10 parts of ginseng, 0.1 to 0.2 parts of ginseng peptide, 1 to 2 parts of emblica fruit, and 1 to 2 parts of magnesium stearate.

[0045] At this time, the Polygonatum sibiricum and ginseng peptide tablets of this embodiment, by adopting a specific ratio of Polygonatum sibiricum and ginseng, and coordinating with wheat oligopeptides, emblica fruit, etc., can make the Polygonatum sibiricum and ginseng peptide tablets of the present invention have significant effects of replenishing qi and nourishing yin, invigorating the kidney and strengthening the spleen, thereby improving the problem of kidney essence deficiency in the human body.

[0046] In the formula of Polygonatum ginseng peptide tablets, Polygonatum sibiricum is sweet and flat in nature. It enters the spleen, lung and kidney meridians, and has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs and benefiting the kidneys. And it is used for spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, dry cough due to lung deficiency, hemoptysis due to fatigue, insufficient essence and blood, soreness of waist and knees, premature graying of hair, internal heat and thirst, etc. In the specific preparation, the weight of Polygonatum sibiricum can be set to 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 37 parts or 40 parts, etc.

[0047] In addition, wheat oligopeptides can promote the improvement of skeletal muscle SOD activity, accelerate the removal of free radicals, effectively protect cells from sports injuries, and effectively maintain the body's athletic ability. At the same time, wheat oligopeptides themselves have antioxidant activity and strong reducing ability, and can directly combine with free radicals to combat free radical damage. Moreover, wheat oligopeptides can promote the absorption of nutrients while protecting the normal functioning of the spleen and stomach. In the specific preparation, the weight portions of wheat oligopeptides can be set to, for example, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts or 40 parts, etc.

[0048] Secondly, sorbitol has multiple functions such as excipient, adhesiveness, hygroscopicity, etc., and can be used as a binder, disintegrant and filler for direct tableting, and is widely used in the preparation process of chewable tablets, laminated tablets, sugar-coated tablets and film-coated tablets. In addition, sorbitol has a sweet taste, which can effectively improve the taste of the product and enhance the comfort of taking. In the specific preparation, the weight of sorbitol can be set to 16 parts, 18 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts or 28 parts, etc.

[0049] In the formula of Huangjing Ginseng Peptide Tablets, ginseng tastes sweet, slightly bitter, and is slightly warm in nature. It enters the spleen, lung, heart, and kidney meridians. It has the effects of greatly replenishing vital energy, restoring pulse and consolidating deficiency, replenishing spleen and lung, promoting body fluid and nourishing blood, calming the mind and improving intelligence. It is often used to treat symptoms such as physical weakness and weakness, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and coughing, thirst due to loss of body fluid, internal heat and thirst, qi and blood deficiency, long-term illness and weakness, palpitations and insomnia, impotence and cold uterus. In the specific preparation, the weight of ginseng can be set to 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc.

[0050] Ginseng peptide is an active polypeptide substance extracted from ginseng, rich in superoxide dismutase, glutathione peroxidase and other antioxidants. It can not only inhibit platelet aggregation, improve blood fluidity, and reduce the risk of thrombosis, but also stimulate gastric acid secretion, thereby promoting digestion and absorption, and on the basis of protecting the spleen and stomach, it can further improve the body's intake and utilization efficiency of nutrients. In the specific preparation, the weight of ginseng peptide can be set to 0.1 parts, 0.15 parts or 0.2 parts, etc.

[0051] Phyllanthus emblica is sweet, sour, astringent and cool in nature. It enters the lung and stomach meridians. It has the effects of clearing away heat and cooling blood, promoting digestion and strengthening the stomach, promoting body fluid and relieving cough. It can be used to improve and treat symptoms such as blood heat and blood stasis, indigestion, abdominal distension, cough, sore throat, and dry mouth. At the same time, while Phyllanthus emblica has the function of strengthening the spleen and stomach, it also helps to promote digestion and absorption, and cooperates with other ingredients to jointly maintain the healthy balance of the human digestive system. In the specific preparation, the weight portions of Phyllanthus emblica can be set to 1 part, 1.5 parts or 2 parts, etc.

[0052] In addition, magnesium stearate is mainly used as a glidant in the preparation process, which can effectively improve the fluidity of the material, ensure that the material can flow and fill evenly and smoothly in the production process such as tableting, and ensure the molding quality and production efficiency of the product. In the specific preparation, the weight of magnesium stearate can be set to 1 part, 1.5 parts or 2 parts, for example.

[0053] In the present invention, both Polygonatum and Ginseng belong to the kidney meridian, and both have the effects of replenishing Qi and nourishing Yin, and tonifying the kidney and spleen. Wheat oligopeptides, ginseng peptides, and Phyllanthus emblica can promote the absorption of various nutrients by the human body while playing the role of protecting the spleen and stomach. In the Polygonatum ginseng peptide tablets of the present invention, the various raw materials cooperate with each other, so that the prepared Polygonatum ginseng peptide tablets show relatively excellent effects in replenishing Qi and nourishing Yin, tonifying the kidney and spleen, thereby effectively improving a series of health problems caused by human kidney essence deficiency, and providing comprehensive and in-depth nourishment and care for human health.

[0054] In addition, this embodiment also relates to a method for preparing the above-mentioned Polygonatum ginseng peptide tablets, which comprises the following steps:

[0055] Step S1, weighing polygonatum, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblica fruit and magnesium stearate according to weight parts.

[0056] During the specific preparation, the particle size of polygonatum, emblica and sorbitol is not greater than 40 mesh. When the particle size of the raw materials such as polygonatum, emblica and sorbitol is relatively large, for example, these raw materials can be crushed by a pulverizer, and then sieved through a 40-mesh screen, and the raw materials with a particle size of no more than 40 mesh are taken for standby use.

[0057] Step S2, dividing the weighed wheat oligopeptide into two equal parts, taking one of the wheat oligopeptide and mixing it evenly with the weighed sorbitol, ginseng powder, ginseng peptide powder and emblica to obtain a first mixed powder; mixing the other wheat oligopeptide and the weighed polygonatum to obtain a second mixed powder.

[0058] In this step, the wheat oligopeptide is divided into two parts and mixed with other raw materials respectively, which is conducive to the uniform dispersion and preliminary fusion of different raw materials. Among them, one part of wheat oligopeptide is mixed with sorbitol, ginseng powder, ginseng peptide powder, and emblica, which can make the ingredients with antioxidant and absorption-promoting functions fully contact first, which is conducive to the formation of a uniform first mixed powder in the subsequent granulation process, ensuring that the functional ingredients in the product are evenly distributed, so that the efficacy of each piece of product can be stably exerted. Another part of wheat oligopeptide is mixed with Polygonatum to form a second mixed powder. Considering the characteristics of Polygonatum, it can be better combined with wheat oligopeptide, laying the foundation for the synergistic effect of subsequent processing and the efficacy of the final product.

[0059] At the same time, the wheat oligopeptide is divided into two equal parts to prepare the premix, which is conducive to the uniform dispersion and preliminary fusion of different raw materials. Among them, one part of wheat oligopeptide is mixed with sorbitol, ginseng powder, ginseng peptide powder, and emblica, which can make the ingredients with antioxidant and absorption-promoting functions fully contact first, which is conducive to the formation of a uniform first mixed powder in the subsequent granulation process, ensuring that the functional ingredients in the product are evenly distributed, so that the efficacy of each piece of product can be stably exerted. Another part of wheat oligopeptide is mixed with Polygonatum sibiricum to form a second mixed powder. Considering the characteristics of Polygonatum sibiricum, it can be better combined with wheat oligopeptide, laying the foundation for the synergistic effect of subsequent processing and the efficacy of the final product.

[0060] Step S3, preparing the first mixed powder and the second mixed powder into uniform first wet granules and second wet granules respectively.

[0061] In this step, the binder for preparing the first wet granules is 90% ethanol, and the binder for preparing the second wet granules is 95% ethanol. When specifically implemented, 90% ethanol is added to the first mixed powder to make uniform first wet granules, and 95% ethanol is added to the second mixed powder to make uniform second wet granules. At this time, 90% ethanol is used as the binder for the first wet granules and 95% ethanol is used as the binder for the second wet granules. Ethanol of different concentrations can adjust the formability and viscosity of the granules according to the characteristics of different raw material combinations. Suitable binder concentration can make the raw material powders better bond together to form granules, ensure the integrity and strength of the granules, facilitate subsequent drying, mixing and other operations, and will not affect other properties such as solubility due to excessive viscosity, which is conducive to the disintegration of the product in the body and the release of active ingredients.

[0062] Step S4, drying the first wet granules and the second wet granules respectively to obtain dried first premixed granules and second premixed granules.

[0063] In this step, the first wet granules and the second wet granules are placed in an oven for drying respectively. During the specific preparation, the drying temperatures of the first wet granules and the second wet granules are different. The drying temperature of the first wet granules is 55°C, and the drying temperature of the second wet granules is 40°C. At this time, different drying temperatures are set for the first wet granules and the second wet granules, taking into account the possible differences in the thermal sensitivity and drying characteristics of different raw material combinations. In this way, while ensuring the drying effect of the particles, the effective ingredients and activity of each raw material can be retained to the maximum extent, avoiding the inactivation of certain ingredients due to excessively high temperatures, thereby ensuring that the quality and efficacy of the Polygonatum ginseng peptide tablets are not affected.

[0064] After the first wet granules and the second wet granules are dried, dried first premixed granules and second premixed granules are obtained. The particle size of the first premixed granules is not greater than 20 mesh, and the particle size of the second premixed granules is not greater than 20 mesh. In the specific preparation, for example, the dried first premixed granules and the second premixed granules are sieved through a 20-mesh screen to obtain dry materials with a desired particle size.

[0065] In addition, in this step, the moisture content of the dried first premixed particles and the dried second premixed particles is no more than 7.5%. This can prevent the particles from becoming moldy and deteriorating due to excessive moisture content, thereby extending the shelf life of the product. The appropriate moisture content is also conducive to subsequent mixing with magnesium stearate and tableting operations, ensuring the stability and molding quality of the product.

[0066] It should be noted that in step S4, only the water content of the first premixed particles after drying may be limited to no more than 7.5%, or only the water content of the second premixed particles after drying may be limited to no more than 7.5%. In this case, the total water content of the first premixed particles and the second premixed particles should be ensured to be no more than 7.5% as much as possible, and this setting is also feasible.

[0067] Step S5: mixing the first premixed granules and the second premixed granules with magnesium stearate to obtain a total mixed powder.

[0068] In this step, magnesium stearate is used as a glidant, which can significantly improve the fluidity of the particles after being mixed with the first premixed particles and the second premixed particles. During the tableting process, the material can be evenly filled into the mold, which is conducive to ensuring that each piece of Polygonatum ginseng peptide tablet is tableted according to the preset weight, which is conducive to meeting the quality standard requirements, and is also conducive to improving the tableting efficiency and the integrity and aesthetics of the tablet shape.

[0069] Step S6: Compress the total mixed powder into tablets according to a preset weight to obtain polygonatum ginseng peptide tablets. In this step, the preset weight is 0.55 g / tablet, and the weight difference limit is ±5%.

[0070] When tableting, the tablets are pressed according to the preset weight, which can accurately control the specifications and dosage of the product, making it convenient for consumers to take it according to the prescribed dosage, ensuring the effectiveness and safety of the product, and enabling the Polygonatum ginseng peptide tablets to play a regulatory role on human health according to the expected efficacy and mode of action, such as improving problems such as kidney essence deficiency.

[0071] The present invention will be further described below in conjunction with specific embodiments:

[0072] Example 1

[0073] A polygonatum ginseng peptide tablet comprises the following raw materials in parts by weight: 35 parts of polygonatum ginseng, 35 parts of wheat oligopeptides, 20.9 parts of sorbitol, 7 parts of ginseng, 0.1 parts of ginseng peptide, 1 part of emblica fruit and 1 part of magnesium stearate.

[0074] The preparation method of the above-mentioned Polygonatum ginseng peptide tablets adopts the following production process: raw material weighing → premixing → granulation → total mixing → tableting. And the preparation method specifically includes the following steps:

[0075] Step S1, weighing polygonatum, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblica fruit and magnesium stearate according to weight proportions. The particle size of polygonatum, emblica fruit and sorbitol is not greater than 40 meshes.

[0076] Step S2, dividing the weighed wheat oligopeptide into two equal parts, taking one of the wheat oligopeptide and mixing it evenly with the weighed sorbitol, ginseng powder, ginseng peptide powder and emblica to obtain a first mixed powder; mixing the other wheat oligopeptide and the weighed polygonatum to obtain a second mixed powder.

[0077] Step S3, preparing the first mixed powder and the second mixed powder into uniform first wet granules and second wet granules respectively. Specifically, adding 90% ethanol to the first mixed powder to prepare uniform first wet granules, and adding 95% ethanol to the second mixed powder to prepare uniform second wet granules.

[0078] Step S4, drying the first wet granules and the second wet granules respectively to obtain dried first premixed granules and second premixed granules. Specifically, the first wet granules and the second wet granules are placed in an oven for drying, the drying temperature of the first wet granules is 55° C., and the drying temperature of the second wet granules is 40° C. The water content of the dried first premixed granules and the water content of the dried second premixed granules are both not greater than 7.5%.

[0079] Step S5, mixing the first premixed granules and the second premixed granules with magnesium stearate for a certain time, for example, 20 minutes, to obtain a total mixed powder.

[0080] Step S6, the total mixed powder is loaded into a tablet press and tableted according to a preset weight to obtain a polygonatum ginseng peptide tablet. The preset weight is 0.55 g / tablet, and the weight difference limit is required to be ±5%. In addition, during the pressing process, the obtained polygonatum ginseng peptide tablet is regularly checked to ensure that the quality of the obtained polygonatum ginseng peptide tablet meets the preparation standard.

[0081] Example 2

[0082] A polygonatum ginseng peptide tablet comprises the following raw materials in parts by weight: 30 parts of polygonatum ginseng, 40 parts of wheat oligopeptides, 22.8 parts of sorbitol, 4 parts of ginseng, 0.2 parts of ginseng peptide, 1 part of emblica fruit and 2 parts of magnesium stearate.

[0083] The preparation method of the Polygonatum ginseng peptide tablets in this example is the same as that in Example 1.

[0084] Example 3

[0085] A polygonatum ginseng peptide tablet comprises the following raw materials in weight fractions: 25 parts of polygonatum ginseng, 40 parts of wheat oligopeptide, 21.9 parts of sorbitol, 10 parts of ginseng, 0.1 parts of ginseng peptide, 2 parts of emblica fruit and 1 part of magnesium stearate.

[0086] The preparation method of the Polygonatum ginseng peptide tablets in this example is the same as that in Example 1.

[0087] Example 4

[0088] A polygonatum ginseng peptide tablet comprises the following raw materials in parts by weight: 40 parts of polygonatum ginseng, 30 parts of wheat oligopeptide, 16.8 parts of sorbitol, 10 parts of ginseng, 0.2 parts of ginseng peptide, 1 part of emblica fruit and 2 parts of magnesium stearate.

[0089] The preparation method of the Polygonatum ginseng peptide tablets in this example is the same as that in Example 1.

[0090] Example 5

[0091] A polygonatum ginseng peptide tablet comprises the following raw materials in parts by weight: 30 parts of polygonatum ginseng, 35 parts of wheat oligopeptide, 27.9 parts of sorbitol, 4 parts of ginseng, 0.1 part of ginseng peptide, 2 parts of emblica fruit and 1 part of magnesium stearate.

[0092] The preparation method of the Polygonatum ginseng peptide tablets in this example is the same as that in Example 1.

[0093] Example 6

[0094] A polygonatum ginseng peptide tablet comprises the following raw materials in parts by weight: 25 parts of polygonatum ginseng, 40 parts of wheat oligopeptide, 24.8 parts of sorbitol, 7 parts of ginseng, 0.2 parts of ginseng peptide, 1 part of emblica fruit and 2 parts of magnesium stearate.

[0095] The preparation method of the Polygonatum ginseng peptide tablets in this example is the same as that in Example 1.

[0096] Comparative Example 1

[0097] A composition comprises the following raw materials in parts by weight: 35 parts of wheat oligopeptide, 20.9 parts of sorbitol, 7 parts of ginseng, 0.1 parts of ginseng peptide, 1 part of emblica fruit and 1 part of magnesium stearate.

[0098] The preparation method of the composition of this comparative example comprises the following steps:

[0099] Step S1, weigh wheat oligopeptides, sorbitol, ginseng, ginseng peptides, emblica fruit and magnesium stearate according to weight proportions, wherein the particle size of emblica fruit and sorbitol is not greater than 40 meshes.

[0100] Step S2, dividing the weighed wheat oligopeptide into two equal parts, taking one of the wheat oligopeptide and mixing it evenly with the weighed sorbitol, ginseng powder, ginseng peptide powder and emblica to obtain a first mixed powder.

[0101] Step S3, preparing uniform first wet granules from the first mixed powder. Specifically, 90% ethanol is added to the first mixed powder to prepare uniform first wet granules.

[0102] Step S4, drying the first wet particles to obtain dried first premixed particles. Specifically, the first wet particles are placed in an oven for drying, and the drying temperature of the first wet particles is 55° C. The moisture content of the dried first premixed particles is not greater than 7.5%.

[0103] Step S5: Mix the first premixed particles with magnesium stearate for a certain period of time, for example, 20 minutes, to obtain a total mixed powder.

[0104] Step S6, the total mixed powder is loaded into a tablet press and tabletted according to a preset weight to obtain a composite tablet. The preset weight is 0.55 g / tablet, and the weight difference limit is required to be ±5%. In addition, during the pressing process, the obtained composite tablet is regularly inspected to ensure that the quality of the obtained composite tablet meets the preparation standard.

[0105] Comparative Example 2

[0106] A composition comprises the following raw materials in parts by weight: 35 parts of polygonatum, 35 parts of wheat oligopeptide, 20.9 parts of sorbitol, 0.1 parts of ginseng peptide, 1 part of emblica fruit and 1 part of magnesium stearate.

[0107] The preparation method of the composition of this comparative example comprises the following steps:

[0108] Step S1, weighing polygonatum, wheat oligopeptide, sorbitol, ginseng peptide, emblica fruit and magnesium stearate according to weight proportions. The particle sizes of polygonatum, emblica fruit and sorbitol are not greater than 40 meshes.

[0109] Step S2, dividing the weighed wheat oligopeptide into two equal parts, taking one of the wheat oligopeptide and mixing it evenly with the weighed sorbitol, ginseng peptide powder and emblica to obtain a first mixed powder; mixing the other wheat oligopeptide and the weighed polygonatum to obtain a second mixed powder.

[0110] Step S3, preparing the first mixed powder and the second mixed powder into uniform first wet granules and second wet granules respectively. Specifically, adding 90% ethanol to the first mixed powder to prepare uniform first wet granules, and adding 95% ethanol to the second mixed powder to prepare uniform second wet granules.

[0111] Step S4, drying the first wet granules and the second wet granules respectively to obtain dried first premixed granules and second premixed granules. Specifically, the first wet granules and the second wet granules are placed in an oven for drying, the drying temperature of the first wet granules is 55° C., and the drying temperature of the second wet granules is 40° C. The water content of the dried first premixed granules and the water content of the dried second premixed granules are both not greater than 7.5%.

[0112] Step S5, mixing the first premixed granules and the second premixed granules with magnesium stearate for a certain time, for example, 20 minutes, to obtain a total mixed powder.

[0113] Step S6, the total mixed powder is loaded into a tablet press and tabletted according to a preset weight to obtain a composite tablet. The preset weight is 0.55 g / tablet, and the weight difference limit is required to be ±5%. In addition, during the pressing process, the obtained composite tablet is regularly inspected to ensure that the quality of the obtained composite tablet meets the preparation standard.

[0114] The following is an evaluation of the ability of the Polygonatum ginseng peptide tablets prepared in the above examples to improve kidney essence deficiency:

[0115] The present invention explains in detail the mechanism of the effect of Polygonatum ginseng peptide tablets on improving kidney essence deficiency in mice through indicators such as body weight, number of autonomous activities, swimming activity time and the like of mice with kidney yang deficiency.

[0116] First, the model was prepared. 70 ICR mice with a body weight of about 20 g were selected and randomly divided into 7 groups, namely control group 1, control group 2, comparative example group 1, comparative example group 2, low-dose group, medium-dose group, and high-dose group, with 10 mice in each group.

[0117] Next, except for the control group 1 and the control group 2, the mice in the comparative example group 1, the comparative example group 2, the low-dose group, the medium-dose group, and the high-dose group were administered with the Polygonatum ginseng peptide tablets.

[0118] The administration method is as follows: the dosage is calculated according to the "equivalent conversion ratio of experimental animals and humans based on body surface area", and the low-dose group, medium-dose group, and high-dose group are respectively given 7 mg / kg, 35 mg / kg, and 70 mg / kg by gavage. The comparative example group 1 and the comparative example group 2 are both given 70 mg / kg by gavage. The control group 1 and the control group 2 are given an equal volume of distilled water by gavage. The administration starts on the day of grouping, once a day, and is continued for 10 days.

[0119] Then, starting from the 7th day of administration, except for the control group 1, the other groups were injected with hydrocortisone injection at the same time, and the injection was continued for 3 days. It should be noted that the injection of hydrocortisone to prepare the mouse kidney yang deficiency animal model is to use exogenous glucocorticoids to inhibit the release of adrenocorticotropic hormone in the anterior pituitary gland, so as to reduce the secretion of steroid hormones by the adrenal cortex. The mice injected with hydrocortisone showed symptoms such as reduced body weight, weakened activity, and decreased cold and fatigue resistance.

[0120] One hour after the last administration on the 10th day, the body weight, number of spontaneous activities and swimming survival time of the mice with kidney yang deficiency were measured, and the body weight, number of spontaneous activities (within 10 minutes) and low temperature (18°C) swimming survival time of each group of animals were recorded.

[0121] Table 1 Effects on body weight of mice

[0122] Group Before administration (g) After administration (g) Difference(g) Control group 1 20.49±0.51 28.06±1.23 7.57 Control group 2 20.60±0.26 24.69±1.16 4.06 Comparative Example 1 20.51±0.42 25.13±1.29 4.62 Comparative Example 2 20.53±0.48 25.42±1.21 4.89 Low dose group 20.56±0.46 25.23±1.71 4.67 Medium dose group 20.55±0.39 25.35±1.53 4.80 High dose group 20.33±0.53 25.29±1.96 4.96

[0123] Table 2 Effects on mice with kidney yang deficiency

[0124]

[0125]

[0126] From the above results, it can be seen that by comparing the body weight, number of spontaneous activities, and swimming survival time of mice with kidney yang deficiency, the mice in the control group 2 had the largest weight loss, and the least number of spontaneous activities and low-temperature swimming survival time; the mice in the high-dose group taking high-dose Polygonatum ginseng peptide tablets had the least weight loss, and the number of spontaneous activities and low-temperature swimming survival time were slightly longer than those in the control group 1, control group 2, low-dose group, and medium-dose group; under the same dose (70 mg / kg), that is, the high-dose group, control group 1 lacking the Polygonatum component, and control group 2 lacking the ginseng component, compared with the three groups, the mice in the high-dose group had the least weight loss, the longest number of spontaneous activities and low-temperature swimming survival time, and the effect was more obvious.

[0127] It can be seen that Polygonatum ginseng peptide tablets can increase the number of spontaneous activities of mice with kidney yang deficiency and prolong the low-temperature swimming time, and the effect of the high-dose group is more significant, and it has the effect of delaying the trend of body weight decline in mice with kidney yang deficiency caused by hydrocortisone.

[0128] That is to say, after the Polygonatum ginseng peptide tablets of the present invention are taken by animals with kidney yang deficiency, the various symptoms of kidney yang deficiency in the animals with kidney yang deficiency, i.e. mice, are alleviated. This shows that the Polygonatum ginseng peptide tablets have the effect of replenishing kidney yang, can enhance the body functions of animals and improve tolerance to adverse external stimuli.

[0129] In addition, from the data in the above table, it can be clearly seen that the Polygonatum sibiricum Ginseng Peptide Tablets, which contain Polygonatum sibiricum, wheat oligopeptides, sorbitol, ginseng, ginseng peptides, emblica fruit and magnesium stearate, utilize the combination of Polygonatum sibiricum, ginseng and ginseng peptides in the raw materials, and cooperate with wheat oligopeptides, sorbitol, emblica fruit, etc., to show more outstanding effects in replenishing qi and nourishing yin, benefiting the kidney and strengthening the spleen, thereby effectively improving the problem of kidney essence deficiency in the human body.

[0130] In addition, the present invention also proposes an application of the above-mentioned Polygonatum ginseng peptide tablets, which are used in the preparation of foods for improving kidney essence deficiency, health foods or special diets.

[0131] In the present invention, the polygonatum ginseng peptide tablets are used in the preparation of foods for improving kidney essence deficiency, health foods or special diets, so that the prepared foods for improving kidney essence deficiency, health foods and special diets have significant effects of replenishing qi and nourishing yin, benefiting the kidney and strengthening the spleen, thereby improving the problem of kidney essence deficiency in the human body.

[0132] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A polygonatum ginseng peptide tablet, characterized in that: The raw materials for preparing the polygonatum ginseng peptide tablets include: polygonatum ginseng, wheat oligopeptides, sorbitol, ginseng, ginseng peptides, emblica fruit and magnesium stearate.

2. The Polygonatum ginseng peptide tablet according to claim 1, characterized in that: The weight parts of each of the preparation raw materials are respectively: 25 to 40 parts of polygonatum, 30 to 40 parts of wheat oligopeptides, 16 to 28 parts of sorbitol, 4 to 10 parts of ginseng, 0.1 to 0.2 parts of ginseng peptide, 1 to 2 parts of emblica fruit, and 1 to 2 parts of magnesium stearate.

3. A method for preparing polygonatum ginseng peptide tablets, characterized in that: The preparation method comprises: Weigh polygonatum, wheat oligopeptide, sorbitol, ginseng, ginseng peptide, emblica fruit and magnesium stearate according to weight parts; The weighed wheat oligopeptide is evenly divided into two portions, one portion of the wheat oligopeptide is taken and mixed with the weighed sorbitol, the ginseng powder, the ginseng peptide powder and the emblica fruit to obtain a first mixed powder; the other portion of the wheat oligopeptide is evenly mixed with the weighed polygonatum to obtain a second mixed powder; Forming the first mixed powder and the second mixed powder into uniform first wet granules and second wet granules respectively; Drying the first wet granules and the second wet granules respectively to obtain dried first premixed granules and second premixed granules; Mixing the first premixed granules and the second premixed granules with magnesium stearate to obtain a total mixed powder; The total mixed powder is tableted according to a preset weight to prepare polygonatum ginseng peptide tablets.

4. The method for preparing the polygonatum ginseng peptide tablets according to claim 3, characterized in that: The binder for preparing the first wet granules is 90% ethanol; and / or, The binder for preparing the second wet granulation was 95% ethanol.

5. The method for preparing the polygonatum ginseng peptide tablets according to claim 3, characterized in that: The moisture content of the first premixed particles after drying and / or the second premixed particles after drying is not more than 7.5%.

6. The method for preparing the polygonatum ginseng peptide tablets according to claim 3, characterized in that: The preset weight is 0.55 g / tablet, and the weight difference limit is required to be ±5%.

7. The method for preparing the polygonatum ginseng peptide tablets according to claim 3, characterized in that: The first wet granules and the second wet granules are dried at different temperatures.

8. The method for preparing the polygonatum ginseng peptide tablets according to claim 3, characterized in that: The particle size of the first premixed particles is not greater than 20 mesh; and / or, The particle size of the second premixed particles is no greater than 20 meshes.

9. The use of the Polygonatum ginseng peptide tablets according to claim 1 or 2, characterized in that: The polygonatum ginseng peptide tablets are used for preparing foods for improving kidney essence deficiency, health foods or special diets.

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