Multi-angle adjustable centrifugal device

Abstract

The invention relates to the technical field of microfluidic detection, in particular to a multi-angle adjustable centrifugal device. The centrifugal device comprises a first detection rotating disc and a second detection rotating disc, the first detection rotating disc comprises a first center part and a first rotating structure, the first center part is provided with a limiting piece and a first positioning hole, the first rotating structure is provided with an angle adjusting gear assembly, the angle adjusting gear assembly comprises a base and at least one adjusting gear, and the adjusting gear is provided with a sample loading part; a first motor; and the second detection rotating disc is arranged on the first detection rotating disc and comprises a second central part and a second rotating structure, the second central part is provided with a second positioning hole corresponding to the first positioning hole, the periphery of the second rotating structure is provided with a tooth adjusting part, and the tooth adjusting part comprises at least one angle adjusting tooth. According to the invention, items with different detection requirements can be synchronously detected, and the detection time and the detection operation are saved.

Description

Technical Field

[0001] The invention relates to the technical field of microfluidic detection, and in particular to a centrifugal device with multi-angle adjustment. Background Art

[0002] Microfluidics technology is a miniaturized analytical platform that integrates sample preparation and detection processes. It can use centrifugal action on the same device to cause the liquid on the microfluidic chip to mix, separate or react with drugs, thereby completing the corresponding detection project.

[0003] For different types of testing items, the required testing conditions need to be set adaptively.

[0004] For example, patent application CN112444518A discloses a blood type reagent card centrifugal detection device, comprising: a box body with a first opening, a box cover with a second opening, a control module in the box body comprising a servo motor and a controller, a centrifugal disk located above the control module, and connected to the servo motor through a centrifugal shaft; the centrifugal disk comprises a chassis and a saw-shaped ring, the chassis has a plurality of clamping positions, the saw-shaped ring is clamped on the chassis, and the saw-shaped depressions of the saw-shaped ring are aligned with the clamping positions to fix the reagent card on the clamping position; a card loading module is located below the second opening, has a third opening and a sliding door, the sliding door is slid to expose the clamping position, the reagent card is loaded into the clamping position from the inside and abuts against the saw-shaped ring; a waste card bin is provided in the first opening for storing the reagent card withdrawn by the card ejection module; the card ejection module is located above the waste card bin, and the reagent card is ejected by a push-pull rod controlled by an electromagnet, and the reagent card falls into the waste card bin below; an image acquisition module is located above the clamping position to acquire an image of the reagent card in the clamping position. For another example, patent application CN114509575A also discloses a microfluidic detection device.

[0005] However, with the diversification of the structural design of microfluidic chips, for example, patent application CN114563583A discloses a high-throughput micro-reaction blood type positive determination detection device. For another example, patent application CN114324958A discloses a sample adding card and a sample adding component. This diversification of structural design also puts forward higher requirements on the detection capability of microfluidic detection devices.

[0006] Therefore, there is an urgent need for a centrifugal detection device that can be applied to a variety of microfluidic detection chips. Summary of the invention

[0007] The object of the present invention is to provide a centrifugal device with multi-angle adjustment to partially solve or alleviate the above-mentioned deficiencies in the prior art.

[0008] In order to solve the above-mentioned technical problems, the present invention specifically adopts the following technical solutions: The present invention provides a centrifugal device with multi-angle adjustment, which is used to detect microfluidic chips and includes: a first detection turntable that can rotate around a rotation axis, the first detection turntable includes a first central part and a first rotating structure that are connected, a limit piece and a first positioning hole are provided on the first central part, an angle adjustment gear assembly is provided on the first rotating structure, the angle adjustment gear assembly includes a base and at least one adjustment gear, the adjustment gear is provided on the base, a sample loading part is provided on the adjustment gear, and the sample loading part is used to load the microfluidic chip.

[0009] The first motor is used to drive the first detection turntable to rotate around the rotation axis.

[0010] A second detection turntable, the second detection turntable is arranged on the first detection turntable and can rotate coaxially with the first detection turntable around the rotating axis, the second detection turntable includes a second central portion and a second rotating structure connected to each other, the second central portion is provided with a second positioning hole corresponding to the first positioning hole, the outer periphery of the second rotating structure is provided with a tooth adjustment portion that cooperates with the angle adjustment gear assembly, and the tooth adjustment portion includes at least one angle adjustment tooth.

[0011] A second motor, the second motor is used to drive the second detection turntable to rotate around the rotating axis, a pressure block is arranged below the second motor, the second motor and the pressure block are connected by a telescopic rod, the pressure block reciprocates through the telescopic rod under the drive of the second motor, and at least one pressure strip is arranged below the pressure block.

[0012] When the limiting member extends into the second positioning hole through the first positioning hole, the adjusting gear and the angle adjusting teeth engage with each other. At this time, the second detection turntable and the first detection turntable can rotate around the rotating axis under the drive of the first motor, the second detection turntable and the first detection turntable remain relatively stationary, and the sample loading part remains relatively stationary at the first detection angle.

[0013] When the pressure strip moves downward and extends into the second positioning hole under the drive of the second motor, the limit piece is squeezed out of the second positioning hole, and the second detection turntable and the pressure block can rotate synchronously. When the second detection turntable rotates under the drive of the second motor, the adjustment gear rotates relative to the second detection turntable under the drive of the angle adjustment teeth, and the sample loading part also rotates accordingly under the drive of the angle adjustment teeth.

[0014] In some embodiments, at least one first zone and at least one second zone are provided on the adjusting gear, a plurality of first teeth are provided on the first zone with a first distribution density, and a plurality of second teeth are provided on the second zone with a second distribution density, and the first distribution density is different from the second distribution density; correspondingly, the angle adjustment teeth include first angle adjustment teeth and second angle adjustment teeth arranged along the axial direction of the second rotating structure, the density of the first angle adjustment teeth is the same as the first distribution density, and the density of the second angle adjustment teeth is the same as the second distribution density.

[0015] In some embodiments, a first limiting area is further provided on the adjusting gear, and the first limiting area is located between the first area and the second area.

[0016] In other embodiments, a first lifting rod is provided under the second detection turntable, and the second detection turntable automatically rises or falls under the drive of the first lifting rod. When the second detection turntable is in a lifting state at a first height, the first angle adjustment teeth can engage with the first teeth; when the second detection turntable is in a lifting state at a second height, the second angle adjustment teeth can engage with the second teeth.

[0017] In other embodiments, the adjusting gear includes a first adjusting gear and a second adjusting gear, and the centrifugal radius of the first adjusting gear is different from the centrifugal radius of the second adjusting gear.

[0018] In some other embodiments, the adjusting gear further includes a third adjusting gear, and a centrifugal radius of the third adjusting gear is different from the centrifugal radius of the first adjusting gear and the second adjusting gear.

[0019] In other embodiments, a rotating shaft is disposed on the base, and the base rotates around the rotating shaft so that the first adjusting gear, the second adjusting gear and the third adjusting gear can respectively mesh with the angle adjusting teeth.

[0020] In other embodiments, at least one fixed gear is further provided on the first rotating structure, and the fixed gear is provided with a first fixed tooth that matches the adjusting gear. When the fixed gear and the adjusting gear are located at the same height, the fixed gear can mesh with the adjusting gear.

[0021] In other embodiments, at least one first adjustment zone and at least one second adjustment zone are arranged on the angle adjustment teeth, a plurality of first adjustment teeth are arranged on the first adjustment zone with a first adjustment density, a plurality of second adjustment teeth are arranged on the second adjustment zone with a second adjustment density, and the first adjustment density is different from the second adjustment density.

[0022] In some other embodiments, a position detector is further provided on the adjusting gear, and the position detector can detect the rotation angle of the adjusting gear.

[0023] In some other embodiments, the sample loading part includes: a carrier, and at least one fixing member is disposed on the carrier, and the fixing member is used to mount the chip to be tested.

[0024] Beneficial technical effects: The present invention provides a limit-type adjustment mechanism for performing multiple conversions on gear specifications to be suitable for different detection scenarios.

[0025] Specifically, the present invention provides a multi-angle adjustable centrifugal device capable of restrictive multi-position adjustment based on this limiting adjustment mechanism. This limiting adjustment mechanism realizes the adjustment of the centrifugal radius of the microfluidic chip (that is, the adjustment of the centrifugal force) on the one hand through the flexible conversion and regulation of the gear specifications (tooth distribution density or gear radius), and can synchronously change the centrifugal angle of the chip on the other hand, so as to meet the detection requirements of different detection items at the same time, save the operator's time, and improve work efficiency. Specifically, the present invention realizes the synchronous change of the centrifugal angle and centrifugal radius of the microfluidic chip during the centrifugal detection process through the synchronous rotation of the first detection turntable and the second detection turntable driven by the motor, and the relative rotation of the adjustment gear driven by the angle adjustment teeth, and, through the graded setting of the adjustment gear (that is, the gear radius size setting and the gear position setting), it can perform synchronous detection of different items on batch chips.

[0026] Based on this limited adjustment mechanism, the present invention also designs a gear matching assembly for restrictive partition adjustment (i.e., the adjustment gear matches the angle adjustment teeth and the fixed gear, respectively). Specifically, by flexibly zoning the adjustment gear and the angle adjustment teeth, i.e., setting the density of the tooth distribution, it is possible to select a suitable tooth meshing area according to the requirements of the test item for the centrifugal angle, and at the same time improve the accuracy of the angle adjustment to a certain extent, ensure the relative reliability of the centrifugal detection process, avoid inaccurate detection results caused by excessive angle rotation, and this restrictive partition matching design also ensures the stability of the device during angle adjustment, centrifugal radius adjustment and the entire centrifugal detection process. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, each element or part is not necessarily drawn according to the actual scale. Obviously, the drawings described below are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without paying creative labor.

[0028] Figure 1 is a schematic diagram of a first partial structure of a centrifugal device in an exemplary embodiment of the present invention; Figure 2 is a second partial structural schematic diagram of a centrifugal device in an exemplary embodiment of the present invention; Figure 3 A top view of a first partial structure of a centrifugal device in an exemplary embodiment of the present invention; Figure 4 A top view of a second partial structure of a centrifugal device in an exemplary embodiment of the present invention; Figure 5 is a front view of a centrifugal device in an exemplary embodiment of the present invention; Figure 6 is a third partial structural schematic diagram of a centrifugal device in an exemplary embodiment of the present invention; Figure 7 is a fourth partial structural schematic diagram of a centrifugal device in an exemplary embodiment of the present invention; Figure 8 is a fifth partial structural schematic diagram of a centrifugal device in an exemplary embodiment of the present invention; Fig. 9 A top view of a third partial structure of a centrifugal device in an exemplary embodiment of the present invention; Fig.10 A conceptual diagram of a first partition of an adjusting gear in an exemplary embodiment of the present invention; Fig.11 A schematic diagram showing a second partition concept of an adjusting gear in an exemplary embodiment of the present invention; Fig.12 is a schematic diagram of a cross-sectional structure of a second rotating structure in an exemplary embodiment of the present invention; Fig.13 A schematic diagram of the concept of zoning of angle-adjustable teeth in an exemplary embodiment of the present invention; Fig.14 is a schematic structural diagram of a fixed leaf in an exemplary embodiment of the present invention; Fig.15 A top view of a fourth partial structure of a centrifugal device in an exemplary embodiment of the present invention; Fig.16 is a sixth partial structural schematic diagram of a centrifugal device in an exemplary embodiment of the present invention; Fig.17 It is a schematic diagram of the partial structure of an angle adjustment gear assembly in an exemplary embodiment of the present invention.

[0029] Summary of the accompanying drawings: 10, first detection turntable, 101, base, 102, adjustment gear, 102-1, first tooth, 102-2, second tooth, 103, first center portion, 104 first rotating structure, 105, limiter, 106, first positioning hole, 107, positioning mark, 108, bracket structure; 11, rotating shaft; 12, first motor, 121, output shaft; 13, carrier; 14, fixed leaf; 15, shield, 151, opening; 16, upper cover; 20, second detection turntable, 2 01. second center portion, 202. second rotating structure, 203. second positioning hole, 204. angle adjustment teeth, 204-1. first angle adjustment teeth, 204a. first adjustment area, 204b. second adjustment area, 204c. third adjustment area, 204d. fourth adjustment area, 204-2. second angle adjustment teeth, 205. fixed gear; 21. second motor; 22. pressure block, 221. pressure strip; 301. first adjustment gear, 302. second adjustment gear, 303. third adjustment gear. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0031] Herein, suffixes such as "module", "component" or "unit" used to represent elements are only used to facilitate the description of the present invention, and have no specific meanings by themselves. Therefore, "module", "component" or "unit" can be used mixedly.

[0032] In this document, the terms "upper", "lower", "inner", "outer", "front", "back", "one end", "the other end" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0033] In this document, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0034] Herein "and / or" includes any and all combinations of one or more of the associated listed items.

[0035] Herein, "plurality" means two or more than two, ie, it includes two, three, four, five, etc.

[0036] As used in this specification, the term "about" typically means + / - 5% of the stated value, more typically + / - 4% of the stated value, more typically + / - 3% of the stated value, more typically + / - 2% of the stated value, even more typically + / - 1% of the stated value, and even more typically + / - 0.5% of the stated value.

[0037] In this specification, some embodiments may be disclosed in a format of being in a range. It should be understood that this description of "being in a range" is only for convenience and brevity, and should not be interpreted as a rigid limitation on the disclosed range. Therefore, the description of the range should be considered to have specifically disclosed all possible sub-ranges and independent numerical values ​​within this range. For example, the description of the range 1-6 should be considered to have specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as individual numbers within this range, such as 1, 2, 3, 4, 5 and 6. Regardless of the breadth of the range, the above rules apply.

[0038] In the actual testing process, for the testing of different types of items, such as blood type testing and nucleic acid testing, which have different requirements for testing conditions, such as centrifugal force and centrifugal angle, existing centrifugal testing equipment often needs to perform centrifugal testing separately. Usually, the parameters can only be set once during one centrifugation process, which can only meet the centrifugation requirements of one test item. Therefore, when it is urgent to test multiple items at the same time, centrifugation needs to be performed in sequence. Especially when the sample size is large and the centrifugal equipment is limited, it is more likely to waste time. In addition, during the long waiting time for centrifugation, the prepared test samples may also face the risk of failure. Therefore, there is an urgent need for a centrifugal device that can detect multiple items at the same time.

[0039] Gear specification: In this article, "gear specification" refers to the gear radius or tooth distribution density of the adjustment gear on the one hand, and the tooth distribution density of the angle adjustment gear on the other hand.

[0040] See also Figure 1-Figure 17 As shown, the present invention provides a centrifugal device with multi-angle adjustment.

[0041] Embodiment 1 See also Figure 2 The present invention provides a centrifugal device with multi-angle adjustment, which is used to detect microfluidic chips, and includes: a first detection turntable 10 that can rotate around a rotation axis 11, the first detection turntable 10 includes a first central portion 103 and a first rotating structure 104 that are connected, a limiting member 105 and a first positioning hole 106 are provided on the first central portion 103, an angle adjustment gear assembly is provided on the first rotating structure 104, the angle adjustment gear assembly includes a base 101 and at least one adjustment gear 102, the adjustment gear is provided on the base, a sample loading portion is provided on the adjustment gear, and the sample loading portion is used to load the microfluidic chip.

[0042] The first motor 12 is used to drive the first detection turntable 10 to rotate around the rotation axis 11 .

[0043] The second detection turntable 20, see Figure 1 The second detection turntable 20 is arranged on the first detection turntable 10 and can rotate coaxially with the first rotation axis 11 together with the first rotation axis 10. The second detection turntable includes a second central portion 201 and a second rotation structure 202 connected to each other. The second central portion is provided with a second positioning hole 203 corresponding to the first positioning hole. The outer periphery of the second rotation structure 202 is provided with a tooth adjustment portion that cooperates with the angle adjustment gear assembly, and the tooth adjustment portion includes at least one angle adjustment tooth 204.

[0044] The second motor 21 is used to drive the second detection turntable to rotate around the rotating shaft 11. A pressure block 22 is arranged below the second motor. The second motor and the pressure block are connected by a telescopic rod. The pressure block 22 reciprocates through the telescopic rod under the drive of the second motor. At least one pressure strip 221 is arranged below the pressure block 22.

[0045] When the stopper 105 extends into the second positioning hole through the first positioning hole, the adjusting gear 102 and the angle adjusting teeth 204 mesh with each other, and at this time, the second detection turntable 20 and the first detection turntable 10 can rotate around the rotation axis under the drive of the first motor 12, and the second detection turntable 20 and the first detection turntable 10 remain relatively stationary, and the sample loading part remains relatively stationary at the first detection angle; When the pressure bar 221 moves downward and extends into the second positioning hole 203 under the drive of the second motor, the limit member is squeezed out of the second positioning hole, and the second detection turntable and the pressure block can rotate synchronously. When the second detection turntable rotates under the drive of the second motor, the adjusting gear 102 rotates relative to the second detection turntable driven by the angle adjustment teeth 204, and the sample loading part also rotates accordingly under the drive of the adjusting gear.

[0046] In some other embodiments, an elastic member is disposed below the limiting member 105 , and when the limiting member is squeezed by the pressure strip, the elastic member may be compressed in the first positioning hole.

[0047] Furthermore, in some embodiments, the limiting member is a fixed top bead, and the elastic member is a spring.

[0048] In some embodiments, see Fig.10 , the adjusting gear is provided with at least one first zone I and at least one second zone II, the first zone is provided with a plurality of first teeth 102-1 with a first distribution density, the second zone is provided with a plurality of second teeth 102-2 with a second distribution density, the first distribution density is different from the second distribution density; correspondingly, see Fig.12 The angle adjustment teeth include a first angle adjustment tooth 204-1 and a second angle adjustment tooth 204-2 arranged along the axial direction of the second rotating structure, the density of the first angle adjustment tooth 204-1 is the same as the first distribution density, and the density of the second angle adjustment tooth 204-2 is the same as the second distribution density, so that the first zone rotates a first angle under the drive of the first angle adjustment tooth, and the second zone rotates a second angle under the drive of the second angle adjustment tooth, and the first angle is different from the second angle.

[0049] That is to say, the first angle adjustment teeth can mesh with the first area, and the second angle adjustment teeth can mesh with the second area. Since the first teeth and the second teeth have different densities, when the first angle adjustment teeth and the second angle adjustment teeth are respectively meshed with the first area and the second area, under the condition that the angle adjustment teeth 204 rotate at the same angle, the adjustment gear can rotate at different angles (i.e., the first angle and the second angle), thereby causing the sample loading portion to rotate at corresponding angles.

[0050] Specifically, in some embodiments, the first distribution density of the first zone is greater than the second distribution density of the second zone. For example, the angle of a tooth in the first zone changes by 1° each time a tooth rotates, and the angle of a tooth in the second zone changes by 10° each time a tooth rotates. When the detection chip needs to be slightly adjusted in angle, such as when it needs to be rotated 5-10° to meet the centrifugal force requirement, the first zone can be selected to engage with the first angle adjustment teeth to achieve precise angle control of the chip; when the detection chip needs a larger angle adjustment, such as when it needs to be rotated 50-100°, the second zone can be selected to engage with the second angle adjustment teeth. Compared with selecting the first zone to engage with the first angle adjustment teeth, selecting the second zone for adjustment can greatly improve the efficiency of the angle adjustment while ensuring the accuracy of the angle change, save the time for angle adjustment, reduce the number of rotations of the angle adjustment teeth, and reduce the wear of the angle adjustment teeth.

[0051] In some embodiments, a first limiting area III is further provided on the adjusting gear 102. The first limiting area may be a concave surface obtained by inwardly recessing the edge of the adjusting gear. The first limiting area is located between the first area I and the second area II.

[0052] Further, in some embodiments, the first limiting area can be a smooth curved surface. In other words, any structure that can prevent the adjusting gear from engaging with the angle adjusting teeth can be the first limiting area. The first limiting area is used to limit the rotation angle of the adjusting gear driven by the angle adjusting teeth to prevent the adjusting gear from rotating too much, that is, to avoid excessive rotation causing improper friction on the teeth at the edge of the first zone or the second zone, thereby affecting the service life of the adjusting gear and the tooth adjustment part.

[0053] In other embodiments, a second limiting area may be provided on the angle adjustment tooth, for example, the second limiting area may be provided on the first angle adjustment tooth 204-1, and the formation method thereof is similar to that of the first limiting area. The provision of the second limiting area is conducive to avoiding tooth wear caused by excessive rotation of the angle adjustment tooth, thereby ensuring the consistency of the rotation angle of each tooth, and helping to maintain the accuracy of angle adjustment during the centrifugation process.

[0054] The centrifugal device of the present invention can select appropriate partitions for different microfluidic chip detection projects (especially detection projects with different centrifugal angles) to accurately control the centrifugal angle while ensuring the angle adjustment efficiency through the partition conversion setting of the tooth distribution density on the adjustment gear and the adaptive setting of the angle adjustment teeth matched therewith.

[0055] In other embodiments, a positioning mark 107 is further provided on the adjusting gear, and the positioning mark can be used in conjunction with a camera. When the camera detects that the tooth area corresponding to the positioning mark 107 is engaged with the angle adjustment tooth, a signal is sent to a control system on the first motor. At this time, the limit member can extend into the second positioning hole through the first positioning hole, and the second detection turntable can rotate coaxially around the rotating axis 11 together with the first detection turntable under the drive of the first motor, and the chip on the sample loading part performs centrifugal motion at the first detection angle.

[0056] In some embodiments, a first lifting rod is provided under the second detection turntable 20, and the second detection turntable automatically rises or falls under the drive of the first lifting rod. When the second detection turntable is in a lifting state at a first height, the first angle adjustment tooth 204-1 is engaged with the first tooth 102-1; when the second detection turntable is in a lifting state at a second height, the second angle adjustment tooth 204-2 is engaged with the second tooth 102-2.

[0057] In some embodiments, the adjusting gear includes a first adjusting gear 301 and a second adjusting gear 302 , and the radius of the first adjusting gear is different from the radius of the second adjusting gear, that is, the sizes of the first adjusting gear and the second adjusting gear are inconsistent.

[0058] In other embodiments, the adjustment gear also includes a third adjustment gear 303, and the radius of the third adjustment gear is different from the radius of the first adjustment gear and the radius of the second adjustment gear, so that when the first adjustment gear, the second adjustment gear and the third adjustment gear are respectively engaged with the angle adjustment teeth, the corresponding first centrifugal radius, the second centrifugal radius and the third centrifugal radius are all different. That is to say, when adjustment gears of different sizes are engaged with the angle adjustment teeth, the centrifugal radii of the chip are different.

[0059] In other embodiments, a rotating shaft is provided on the base 101, and the base rotates around the rotating shaft so that the first adjusting gear, the second adjusting gear and the third adjusting gear can respectively engage with the angle adjusting teeth, thereby being able to intelligently adjust the centrifugal radius of the chip as needed.

[0060] In other embodiments, one base may include only one adjustment gear, while another base may include multiple adjustment gears (see Fig.15 ), for example, two, three or four adjusting gears, each adjusting gear is provided with a sample loading part, wherein the gear radius and tooth distribution density of each adjusting gear can be different, so the centrifugal radius and rotation angle of the chip on the carrier on different adjusting gears are different, which can meet the synchronous centrifugation requirements of detection items requiring different centrifugal forces and centrifugal angles, such as blood type detection and nucleic acid detection, etc., saves detection operation time and improves work efficiency. Therefore, the specific number and setting position of the adjusting gears can be selected according to actual needs, and there is no strict restriction on this.

[0061] The centrifugal device of the present invention can be adapted to detection scenarios with different detection conditions by performing multiple conversion settings on the radius of the adjustment gear and the tooth distribution density (i.e., the gear specifications), and can perform synchronous centrifugal detection on different detection items, thereby improving the efficiency of centrifugal detection while ensuring accurate centrifugation.

[0062] Further, in some other embodiments, the first detection turntable 10 is detachably connected to the first motor 12. For details, see Fig.16 As shown, the first detection turntable 10 is connected to the output shaft 121 of the first motor through the support structure 108.

[0063] In some embodiments, the outer side of the end of the support structure is provided with an external thread, the inner side of the output shaft is provided with an internal thread, and the support structure is threadedly connected to the output shaft. The detachable connection between the first detection turntable and the first motor allows the selection and use of a first detection turntable with different numbers of adjustment gears according to actual centrifugal requirements. For example, when performing a test item requiring a small centrifugal force, such as a blood type test, a first detection turntable with only an adjustment gear of a smaller radius can be selected. When performing a test item such as nucleic acid testing, which is complex and requires a large difference in centrifugal force during the entire test process, a first detection turntable with multiple adjustment gears of different radii on the base can be selected to achieve it.

[0064] In some other embodiments, at least one mounting column 109 is further provided on the base, and the adjusting gear is detachably connected to the base via the mounting column.

[0065] In some embodiments, the outer surface of the first end of the mounting post is provided with a thread, the lower surface of the adjusting gear is recessed inward to form a space for the first end of the mounting post to extend into, the peripheral side wall of the space is provided with a thread, and the mounting post is threadedly connected to the adjusting gear. Specifically, in some embodiments, for example, the mounting posts 109 on the base can be arranged in a straight line (such as Fig.17As shown), it can also be arranged in a triangular manner. Specifically, the adjusting gear can be connected to the mounting column at different positions according to the actual centrifugal needs (such as the centrifugal radius and the centrifugal angle) (that is, the number and position of teeth of different specifications can be flexibly adjusted). The detachable connection between the adjusting gear and the base allows the centrifugal device of the present invention to flexibly perform centrifugal tests on different test items.

[0066] In other embodiments, at least one fixed gear 205 is further provided on the first rotating structure 104, and the fixed gear is provided with a first fixed tooth matched with the adjusting gear, and when the fixed gear and the adjusting gear are at the same height, the fixed gear 205 can mesh with the adjusting gear. Here, "matching" means that the shape and density of the first fixed tooth match the shape and density of the tooth on the adjusting gear, so that the fixed gear can mesh with the adjusting gear.

[0067] In other embodiments, a second lifting rod is provided on the fixed gear, and the fixed gear 205 automatically rises or falls under the drive of the second lifting rod; when the centrifugal angle of the sample loading part needs to change, the fixed gear is driven by the second lifting rod to be at a third height so as to be away from the adjusting gear and not hinder the rotation of the sample loading part; when the second detection turntable 20 and the first detection turntable 10 remain relatively stationary for synchronous centrifugal movement, the fixed gear is driven by the second lifting rod to be at a fourth height so that the fixed gear and the adjusting gear are engaged with each other.

[0068] Specifically, in some embodiments, when it is necessary to simultaneously perform centrifugation on items (such as blood type testing and nucleic acid testing) with different centrifugal requirements (i.e., different centrifugal force magnitudes and centrifugal angles), a plurality of adjustment gears with different radii can be respectively arranged on the base, for example, three. When one of the adjustment gears (the first adjustment gear) is meshed with the angle adjustment teeth, the fixed gear rises to the same height as the other two adjustment gears (the second adjustment gear and the third adjustment gear) under the action of the second lifting rod, and meshes with the other two adjustment gears respectively, so as to ensure the working stability of the device during the centrifugation process, and the gears are not prone to slippage and misalignment. When the centrifugal requirements change (i.e., the centrifugal radius and the centrifugal angle are changed), the fixed gear first descends to a height different from the second adjustment gear and the third adjustment gear, and the base rotates under the action of the rotating shaft, and at this time the second or third adjustment gear is meshed with the angle adjustment teeth.

[0069] In some other embodiments, a position detector is further provided on the adjusting gear 102, and the position detector can detect the rotation angle of the adjusting gear driven by the angle adjusting teeth.

[0070] In some other embodiments, the sample loading part includes: a carrier 13, and at least one fixing member is disposed on the carrier 13, and the fixing member is used to install the chip to be tested.

[0071] In other embodiments, at least one fixed leaf 14 is arranged around the rotating shaft 11 between the first center portion 103 and the second center portion 201 , and the fixed leaf is connected to the first motor. The fixed leaf 14 is used to drive the first detection turntable 10 to perform centrifugal motion under the drive of the first motor 12 .

[0072] In other embodiments, the centrifugal device further includes: a shield 15, and an upper cover 16 cooperating with the shield 15, wherein the shield 15 is configured to surround the first detection turntable 10 and the second detection turntable 20, and the second motor 21 is disposed below the inner center of the upper cover.

[0073] Furthermore, in some embodiments, at least one opening 151 is provided on the shield to facilitate observation of the centrifugal state of the sample loading portion.

[0074] In some embodiments, the angle adjustment teeth 204 are provided with at least one first adjustment area 204a and at least one second adjustment area 204b (eg, Fig.13 As shown in FIG. 1 ), a plurality of first adjustment teeth are arranged on the first adjustment area at a first adjustment density, and a plurality of second adjustment teeth are arranged on the second adjustment area at a second adjustment density. The first adjustment density is different from the second adjustment density. Correspondingly, matching adjustment gears are arranged on the base 101. Further, in other embodiments, a third adjustment area 204c and a fourth adjustment area 204d are also arranged on the angle adjustment teeth (as shown in FIG. Fig.13 As shown), a plurality of third adjustment teeth are arranged on the third adjustment area with a third adjustment density, and a plurality of fourth adjustment teeth are arranged on the fourth adjustment area with a fourth adjustment density. The third adjustment density is different from the fourth adjustment density, and correspondingly, corresponding adjustment gears are also arranged on the base.

[0075] The teeth of the four adjustment zones have different adjustment densities (i.e., tooth distribution densities). When the angle adjustment teeth rotate once, the four adjustment zones can rotate and adjust different angles respectively. In other words, the four adjustment zones on the angle adjustment teeth can adjust four different angle ranges. For example, the first adjustment zone can adjust 5° by rotating one tooth, the second adjustment zone can adjust 10° by rotating one tooth, the third adjustment zone can adjust 25° by rotating one tooth, and the fourth adjustment zone can adjust 40° by rotating one tooth, which is equivalent to generating multiple adjustment scales of different sizes when the angle adjustment teeth rotate once. In other words, the setting of adjustment zones with different tooth distribution densities on the angle adjustment teeth enables the present invention to achieve angle control of different scales through one rotation, and can simultaneously meet the centrifugal requirements of detection items with different centrifugal angles, avoiding multiple centrifugation due to the need for different centrifugal angles, greatly saving centrifugation time, and improving work efficiency.

[0076] In some embodiments, the centrifugal device further includes a differential speed adjustment module, which includes a first working unit and a second working unit.

[0077] The first working unit is configured to regulate the adjusting gear to rotate relative to each other at a first speed during the angle adjustment process when the number of specifications of the enabled adjusting gear is less than or equal to a preset first adjustment number; the specification refers to the tooth distribution density or radius of the adjusting gear. For example, a gear with teeth of two distribution densities is used at the same time, and the number of specifications can be 2.

[0078] The second working unit is configured to, when the number of specifications of the enabled adjusting gear is greater than the first adjustment number, regulate the adjusting gear to rotate relative to each other at a second speed during the angle adjustment process; the second speed is greater than the first speed, and the specification refers to the tooth distribution density or radius of the adjusting gear.

[0079] The setting of the differential adjustment module makes it possible to automatically adjust the speed of the adjustment gear during the angle adjustment process according to the change in the centrifugal angle when performing synchronous inspections on different inspection items. On the one hand, it can appropriately speed up the angle adjustment process and reduce the operation time as a whole. On the other hand, the appropriate reduction in the speed during the multi-angle adjustment process is also conducive to ensuring the accuracy of the angle adjustment and avoiding angle adjustment errors caused by gear slippage due to excessive speed.

[0080] The present invention provides a limit-type adjustment mechanism for performing multiple conversions on gear specifications to be suitable for different detection scenarios.

[0081] Specifically, the present invention provides a multi-angle adjustable centrifugal device capable of restrictive multi-position adjustment based on this limiting adjustment mechanism. This limiting adjustment mechanism realizes the adjustment of the centrifugal radius of the microfluidic chip (that is, the adjustment of the centrifugal force) on the one hand through the flexible conversion and regulation of the gear specifications (tooth distribution density or gear radius), and can synchronously change the centrifugal angle of the chip on the other hand, so as to meet the detection requirements of different detection items at the same time, save the operator's time, and improve work efficiency. Specifically, the present invention realizes the synchronous change of the centrifugal angle and centrifugal radius of the microfluidic chip during the centrifugal detection process through the synchronous rotation of the first detection turntable and the second detection turntable driven by the motor, and the relative rotation of the adjustment gear driven by the angle adjustment teeth, and, through the graded setting of the adjustment gear (that is, the gear radius size setting and the gear position setting), it can perform synchronous detection of different items on batch chips.

[0082] Based on this limited adjustment mechanism, the present invention also designs a gear matching assembly for restrictive partition adjustment (i.e., the adjustment gear matches the angle adjustment teeth and the fixed gear, respectively). Specifically, by flexibly zoning the adjustment gear and the angle adjustment teeth, i.e., setting the density of the tooth distribution, it is possible to select a suitable tooth meshing area according to the requirements of the test item for the centrifugal angle, and at the same time improve the accuracy of the angle adjustment to a certain extent, ensure the relative reliability of the centrifugal detection process, avoid inaccurate detection results caused by excessive angle rotation, and this restrictive partition matching design also ensures the stability of the device during angle adjustment, centrifugal radius adjustment and the entire centrifugal detection process.

[0083] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0084] Through the description of the above implementation methods, those skilled in the art can clearly understand that the above-mentioned embodiment methods can be implemented by means of software plus a necessary general hardware platform, and of course by hardware, but in many cases the former is a better implementation method. Based on such an understanding, the technical solution of the present invention, in essence, or the part that contributes to the prior art, can be embodied in the form of a software product, which is stored in a storage medium (such as ROM / RAM, a magnetic disk, or an optical disk), and includes a number of instructions for a computer terminal (which can be a mobile phone, a computer, a server, or a network device, etc.) to execute the methods described in each embodiment of the present invention.

[0085] The embodiments of the present invention are described above in conjunction with the accompanying drawings, but the present invention is not limited to the above-mentioned specific implementation modes, which are merely illustrative rather than restrictive. Under the guidance of the present invention, ordinary technicians in this field can also make many forms without departing from the scope of protection of the present invention and the claims, all of which are within the protection of the present invention.

Claims

1. A centrifugal device with multi-angle adjustment, characterized in that: The centrifugal device is used to detect the microfluidic chip, and the centrifugal device comprises: A first detection turntable (10) rotatable about a rotation axis (11), the first detection turntable (100) comprising a first central portion (103) and a first rotation structure (104) connected to each other, a limit member (105) and a first positioning hole (106) being provided on the first central portion (103), an angle adjustment gear assembly being provided on the first rotation structure (104), the angle adjustment gear assembly comprising a base (101) and at least one adjustment gear (102), the adjustment gear being provided on the base, a sample loading portion being provided on the adjustment gear, the sample loading portion being used for loading the microfluidic chip; A first motor (12) for driving the first detection turntable (10) to rotate around the rotation axis (11); a second detection turntable (20), the second detection turntable (20) being arranged on the first detection turntable and being capable of coaxially rotating with the first detection turntable around the rotation axis (11), the second detection turntable comprising a second central portion (201) and a second rotation structure (202) connected to each other, the second central portion being provided with a second positioning hole (203) corresponding to the first positioning hole, the outer periphery of the second rotation structure (202) being provided with a tooth adjustment portion cooperating with the adjustment gear, the tooth adjustment portion comprising at least one angle adjustment tooth (204); a second motor (21), the second motor (21) being used for driving the second detection turntable to rotate around the rotation axis (11), a pressing block (22) being arranged below the second motor, the second motor and the pressing block being connected via a telescopic rod, the pressing block (22) being driven by the second motor to reciprocate via the telescopic rod, and at least one pressing strip (221) being arranged below the pressing block (22); When the limiting member (105) extends into the second positioning hole through the first positioning hole, the adjusting gear (102) and the angle adjusting teeth (204) mesh with each other, and at this time, the second detection turntable (20) and the first detection turntable (10) can rotate around the rotation axis under the drive of the first motor (12), the second detection turntable (20) and the first detection turntable (10) remain relatively still, and the sample loading portion remains relatively still at the first detection angle; When the pressure strip (221) moves downward and extends into the second positioning hole (203) under the drive of the second motor, the limiting member is squeezed out of the second positioning hole, and the second detection turntable and the pressure block can rotate synchronously. When the second detection turntable rotates under the drive of the second motor, the adjustment gear (102) rotates relative to the second detection turntable under the drive of the angle adjustment teeth (204), and the sample loading unit also rotates accordingly under the drive of the adjustment gear.

2. The centrifugal device according to claim 1, characterized in that The adjusting gear (102) is provided with at least one first zone (I) and at least one second zone (II), the first zone is provided with a plurality of first teeth (102-1) at a first distribution density, the second zone is provided with a plurality of second teeth (102-2) at a second distribution density, the first distribution density being different from the second distribution density; correspondingly, the angle adjustment teeth (204) include first angle adjustment teeth (204-1) and second angle adjustment teeth (204-2) arranged along the axial direction of the second rotating structure, the density of the first angle adjustment teeth (204-1) being the same as the first distribution density, and the density of the second angle adjustment teeth (204-2) being the same as the second distribution density.

3. The centrifugal device according to claim 2, characterized in that The adjusting gear (102) is also provided with a first limiting area (III), and the first limiting area is located between the first area (I) and the second area (II).

4. The centrifugal device according to claim 2, characterized in that A first lifting rod is arranged below the second detection turntable (20), and the second detection turntable automatically rises or falls under the drive of the first lifting rod; when the second detection turntable is in a lifting state at a first height, the first angle adjustment teeth (204-1) can mesh with the first teeth (102-1); when the second detection turntable is in a lifting state at a second height, the second angle adjustment teeth (204-2) can mesh with the second teeth (102-2).

5. The centrifugal device according to claim 1, characterized in that The adjusting gear comprises a first adjusting gear (301) and a second adjusting gear (302), and the radius of the first adjusting gear is different from the radius of the second adjusting gear.

6. The centrifugal device according to claim 5, characterized in that The adjusting gear further comprises a third adjusting gear (303), the radius of the third adjusting gear being different from the radius of the first adjusting gear and the radius of the second adjusting gear.

7. The centrifugal device according to claim 6, characterized in that The base (101) is provided with a rotating shaft, and the base rotates around the rotating shaft so that the first adjusting gear (301), the second adjusting gear (302) and the third adjusting gear (303) can respectively mesh with the angle adjusting teeth.

8. The centrifugal device according to claim 1, characterized in that At least one fixed gear (205) is also provided on the first rotating structure (104), and a first fixed tooth matched with the adjusting gear is provided on the fixed gear; when the fixed gear and the adjusting gear are located at the same height, the fixed gear (205) can mesh with the adjusting gear.

9. The centrifugal device according to claim 1, characterized in that The angle adjustment teeth (204) are provided with at least one first adjustment area (204a) and at least one second adjustment area (204b), the first adjustment area being provided with a plurality of first adjustment teeth at a first adjustment density, the second adjustment area being provided with a plurality of second adjustment teeth at a second adjustment density, the first adjustment density being different from the second adjustment density.

10. The centrifugal device according to claim 1, characterized in that The adjusting gear (102) is also provided with a position detector, and the position detector is capable of detecting the rotation angle of the adjusting gear.

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