Microfluidic portable food safety analyzer

Abstract

The application relates to a microfluidic portable food safety analyzer, a machine core comprises a base, and a top shell, an optical acquisition module, a pressing assembly, a heating module and a centrifugal assembly which are arranged on the base, and the top shell covers the optical acquisition module, the heating module and the centrifugal assembly; the centrifugal assembly is arranged to bear a disc-type chip to be detected, the optical acquisition module is arranged to be close to a first preset position of the disc-type chip, and the heating module is arranged to be close to a second preset position of the disc-type chip. The chemiluminescence detection is realized, qualitative, semi-quantitative or full-quantitative detection can be realized, the detection sensitivity is wider, and the accuracy is higher; no complex optical path design is adopted, and the precision required by positioning is relatively reduced, so that the requirement of positioning precision is met, and a relatively large error of a detection result is avoided; the device is suitable for detecting the disc-type chip, and detection results of multiple items can be obtained at a time, so that the requirement of high throughput is met; the device has the advantages of simple structure, small overall size, light weight and the like, and is convenient to carry and maintain.

Description

Technical Field

[0001] The present application relates to the field of detection, and in particular to a microfluidic portable food safety analyzer. Background Art

[0002] Food safety is a matter of great concern to human health. How to quickly and accurately detect pathogenic substances such as residual hormones or viruses in food has become a matter of concern to everyone, and as a result, a variety of food safety machine products have appeared on the market. Most existing food safety machines use the immunochromatographic colloidal gold method, which uses reagent strips for qualitative analysis. This can lead to problems with insensitive detection and inaccurate results. Some also use optical mass spectrometry detection technology, utilizing the principle of colorimetry for analysis and testing. However, these instruments can only perform single-project, single-channel testing and analysis, and cannot meet the throughput requirements of multiple projects. They also have a relatively complex structure and are relatively expensive.

[0003] Chinese patent application publication number CN111693471A discloses a food safety machine comprising a housing, an image acquisition module, a core control module, a rotating loading module, and a photoelectric sensor. The patent utilizes colloidal gold technology to integrate four functions: high-throughput test strips, biochips, bacterial colony slides, and culture dish reaction solutions. The device uses a CMOS image sensor for image acquisition, a stepper motor drives the rotation of a multifunctional rotating loading stage, and a photoelectric sensor detects the loading stage's position, which is then used in conjunction with the stepper motor for precise positioning.

[0004] However, the technical solution disclosed in the patent document uses the colloidal gold method. Although it can analyze multiple T lines and C lines, the instrument can only perform qualitative analysis and has shortcomings in detection sensitivity and accuracy.

[0005] In addition, the instrument relies on the accuracy of the stepper motor itself for positioning, while the optical acquisition module has very high requirements for mechanical positioning, which will have a relatively large impact on the result error. Utility Model Content

[0006] Based on this, it is necessary to provide a microfluidic portable food safety analyzer.

[0007] In one embodiment, a microfluidic portable food safety analyzer includes a housing and a core;

[0008] The box includes a shell and an upper cover connected to the shell, the movement is detachably arranged in the shell, and the upper cover is used to cover the shell and expose the movement when opened;

[0009] The movement includes a base and a top shell arranged on the base, an optical collection module, a pressing assembly, a heating module, and a centrifugal assembly, and the top shell is covered on the optical collection module, the pressing assembly, the heating module, and the centrifugal assembly;

[0010] The centrifugal assembly is configured to carry a disc chip to be detected, the optical collection module is configured to be located at a first preset position adjacent to the disc chip, and the heating module is configured to be located at a second preset position adjacent to the disc chip;

[0011] The pressing assembly is arranged on the base or under the top shell, and the pressing assembly is arranged at a third preset position adjacent to the disc chip, so that when the top shell covers the disc chip, the pressing assembly is triggered to be pressed on the disc chip at the third preset position.

[0012] The above-mentioned microfluidic portable food safety analyzer, through the design of an optical acquisition module in conjunction with a heating module and a centrifugal component, realizes chemiluminescence detection on the one hand, and can perform qualitative, semi-quantitative or fully quantitative detection, with a wider detection sensitivity and higher accuracy; on the other hand, it has no complex optical path design, and the accuracy required for positioning is relatively reduced, thereby meeting the requirements of positioning accuracy and avoiding large errors in the detection results; on the other hand, it is suitable for the detection of disc chips, and can realize the simultaneous detection of multiple items, and obtain the detection results of multiple items at one time, thereby meeting the needs of high throughput; on the other hand, it has the advantages of simple structure, small size and light weight of the whole machine, which is easy to carry and easy to maintain.

[0013] In one embodiment, the movement further includes a magnetic module disposed on the base, and the top shell is located above the magnetic module to cover the magnetic module;

[0014] The magnetic attraction module is arranged at a fourth preset position adjacent to the disc chip.

[0015] In one embodiment, the magnetic module is driven by a screw motor and moves up and down relative to the centrifugal assembly.

[0016] In one embodiment, the magnetic module moves up and down relative to the centrifugal assembly under the drive of the screw motor through a guide shaft in conjunction with an oil-free bushing mechanism, or through a guide rail in conjunction with a synchronous belt mechanism, a gear rack mechanism or a cam mechanism.

[0017] In one embodiment, the pressing assembly, the heating module and the magnetic module are respectively arranged around the rotating output shaft of the centrifugal assembly.

[0018] In one embodiment, the optical collection module and / or the pressing assembly is installed on the base or under the top shell through a linear guide rail, and a screw motor is used to drive a cam mechanism or a gear rack structure to drive the linear guide rail to move up and down relative to the centrifugal assembly.

[0019] In one embodiment, the centrifugal component is a synchronous belt transmission mechanism, a hollow shaft motor direct drive mechanism or a gear two-stage reduction mechanism.

[0020] In one embodiment, the heating module includes an upper heating component disposed under the top shell and a lower heating component disposed on the base, so that the second preset position of the disc chip is located between the upper heating component and the lower heating component.

[0021] In one embodiment, the box includes a heat dissipation component, a communication unit, a handle, a consumables placement area, and a touch screen display;

[0022] The heat dissipation component is disposed in the housing and / or in the upper cover;

[0023] The communication unit is arranged in the housing or the upper cover;

[0024] The handle is arranged outside the shell or outside the upper cover;

[0025] The consumable material placement area is arranged in the shell or in the upper cover;

[0026] The touch display screen is arranged outside the shell, outside the upper cover or inside the upper cover.

[0027] In one embodiment, the box further includes a battery assembly, which is detachably disposed in the housing and electrically connected to the communication unit and the touch screen display. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the conventional technology, the following briefly introduces the drawings required for use in the embodiments or the conventional technology descriptions. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0029] Figure 1 This is a structural schematic diagram of an embodiment of the microfluidic portable food safety analyzer described in this application.

[0030] Figure 2 for Figure 1 Another schematic diagram of the identification of the illustrated embodiment.

[0031] Figure 3 for Figure 1 Schematic diagram of the movement of the illustrated embodiment.

[0032] Figure 4 for Figure 3 An enlarged schematic diagram of point A of the illustrated embodiment.

[0033] Figure 5 for Figure 4 The illustrated embodiment is a schematic structural diagram on one side of the top shell.

[0034] Figure 6 for Figure 3 A partial structural diagram of the embodiment shown.

[0035] Figure 7 for Figure 6 A partial structural diagram of the embodiment shown.

[0036] Figure 8 for Figure 6 A schematic cross-sectional view of one direction of the embodiment shown.

[0037] Figure numerals: box body 100, movement 200, microfluidic portable food safety analyzer 300, shell 110, heat dissipation component 120, communication unit 130, handle 140, consumables placement area 150, touch display screen 160, upper cover 170, top shell 210, optical collection module 220, pressing component 230, upper heating component 241, lower heating component 242, centrifugal component 250, magnetic suction module 260, base 270, upper cover 211, lower cavity 212, positioning button 213, pot body 214, upper shell 215, motor 251, transmission belt 252, centrifugal table 253. DETAILED DESCRIPTION

[0038] To make the above-mentioned objects, features, and advantages of the present application more clearly understood, the specific embodiments of the present application are described in detail below with reference to the accompanying drawings. The following description sets forth many specific details to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways than those described herein, and those skilled in the art can make similar improvements without violating the scope of the present application. Therefore, the present application is not limited to the specific embodiments disclosed below.

[0039] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this application are for illustrative purposes only and do not represent the only implementation method.

[0040] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of such features. Throughout the description of this application, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0041] In this application, unless otherwise expressly specified or limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or that the first feature and the second feature are indirectly in contact through an intermediate medium. Furthermore, a first feature being “above,” “above,” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below,” “below,” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0042] Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used in the specification of this application includes any and all combinations of one or more of the relevant listed items.

[0043] The present application discloses a microfluidic portable food safety analyzer, which includes some or all of the technical features of the following embodiments; that is, the microfluidic portable food safety analyzer includes some or all of the following structures. In one embodiment of the present application, a microfluidic portable food safety analyzer includes a housing and a movement; the housing includes a shell and an upper cover connected to the shell, the movement is detachably arranged in the shell, the upper cover is used to seal the shell and reveal the movement in an open state; the movement includes a base and a top shell, an optical collection module, a pressing assembly, a heating module, and a centrifugal assembly arranged on the base, and the top shell is covered on the optical collection module, the pressing assembly, the heating module and the centrifugal assembly; the centrifugal assembly is configured to carry a disc chip to be detected, the optical collection module is configured to be adjacent to a first preset position of the disc chip, and the heating module is configured to be adjacent to a second preset position of the disc chip; the pressing assembly is configured on the base or under the top shell, and the pressing assembly is configured to be adjacent to a third preset position of the disc chip, so that when the top shell covers the disc chip, the pressing assembly is triggered to be pressed on the disc chip at the third preset position. The above-mentioned microfluidic portable food safety analyzer, through the design of an optical acquisition module in conjunction with a heating module and a centrifugal component, realizes chemiluminescence detection on the one hand, and can perform qualitative, semi-quantitative or fully quantitative detection, with a wider detection sensitivity and higher accuracy; on the other hand, it has no complex optical path design, and the accuracy required for positioning is relatively reduced, thereby meeting the requirements of positioning accuracy and avoiding large errors in the detection results; on the other hand, it is suitable for the detection of disc chips, and can realize the simultaneous detection of multiple items, and obtain the detection results of multiple items at one time, thereby meeting the needs of high throughput; on the other hand, it has the advantages of simple structure, small size and light weight of the whole machine, which is easy to carry and easy to maintain.

[0044] The following combination Figures 1 to 8 , the microfluidic portable food safety analyzer is described in detail.

[0045] This application is based on microfluidic technology and uses the principle of chemiluminescence to detect microfluidic portable food safety analyzer. In one embodiment, a microfluidic portable food safety analyzer 300 is as follows: Figure 1As shown, it includes a housing 100 and a movement 200, with the housing 100 protecting the movement 200. The housing 100 includes a shell 110 and an upper cover 170 connected to the shell 110. The movement 200 is detachably disposed in the shell 110. The upper cover 170 is used to cover the shell 110 and expose the movement 200 when opened. The microfluidic portable food safety analyzer 300 can be applied to multiple testing fields. When applied to the food testing field, the microfluidic portable food safety analyzer 300 can be referred to as a portable food safety analyzer, and the same applies to other fields.

[0046] In order to realize the portable function of the microfluidic portable food safety analyzer 300, Figure 2 In one embodiment, the box body 100 includes a heat dissipation component 120, a communication unit 130, a handle 140, a consumable material placement area 150 and a touch screen display 160; in this embodiment, the heat dissipation component 120 is arranged in the shell 110, the communication unit 130 is arranged in the shell 110, the handle 140 is arranged outside the shell 110, the consumable material placement area 150 is arranged in the shell 110, and the touch screen display 160 is arranged in the upper cover 170; specifically, the heat dissipation component 120 is used for heat dissipation, the communication unit 130 is used for data communication, and the handle 140 is used for data communication. The hand 140 is used to lift and carry the microfluidic portable food safety analyzer 300, the consumables placement area 150 is used to accommodate consumables, and the touch screen 160 is used for display and touch control. It can be understood that the communication unit 130 is not the invention point of the present application. The embodiments of the present application directly adopt the communication unit 130 to apply the original function of the communication unit 130. The communication unit 130 can be self-developed and produced, or it can be directly purchased on the market; the touch screen 160 is the same, it can be self-developed and produced, or it can be directly purchased on the market; the remaining embodiments are similar and will not be elaborated on.

[0047] In other embodiments, the heat dissipation component 120 may also be disposed in the upper cover portion 170; or, the heat dissipation component 120 may be partially disposed in the shell 110, and the remaining portion may be disposed in the upper cover portion 170. In other embodiments, the communication unit 130 may also be disposed in the upper cover portion 170. The communication unit 130 is used to implement data communication. In other embodiments, the handle portion 140 may also be disposed outside the upper cover portion 170. In other embodiments, the consumables placement area 150 may also be disposed in the upper cover portion 170; or, the consumables placement area 150 may be partially disposed in the shell 110, and the remaining portion may be disposed in the upper cover portion 170. In other embodiments, the touch screen display 160 may also be disposed outside the shell 110 or outside the upper cover portion 170. That is, the above-mentioned structure, including the positions of the heat dissipation component 120, the communication unit 130, the handle 140, the consumables placement area 150 and the touch screen 160, can be changed to a certain extent, as long as it does not affect the overall structure and function of the microfluidic portable food safety analyzer 300.

[0048] To achieve portable power supply, in one embodiment, the housing 100 further includes a battery assembly, which is detachably disposed within the housing 110 and electrically connected to the communication unit 130 and the touch screen display 160. For embodiments having an optical acquisition module 220, a pressing assembly 230, a heating module, a centrifugal assembly 250, and / or a magnetic module 260, the battery assembly is further electrically connected to the control device of the optical acquisition module 220, the drive device of the pressing assembly 230, the control device of the heating module, the drive device of the centrifugal assembly 250, and / or the drive device of the magnetic module 260. This structural design facilitates the implementation of portable mobile detection functions.

[0049] In each embodiment, Figure 3 As shown, the movement 200 includes a base 270 and a top shell 210 disposed on the base 270, Figure 4 and Figure 5The movement 200 further includes an optical collection module 220, a pressing assembly 230, a heating module, and a centrifugal assembly 250 arranged on the base 270, and the top shell 210 is covered on the optical collection module 220, the pressing assembly 230, the heating module, and the centrifugal assembly 250, that is, the top shell 210 is arranged on the optical collection module 220, the pressing assembly 230, the heating module, and the centrifugal assembly 250, and the top shell 210 covers the optical collection module 220, the pressing assembly 230, the heating module, and the centrifugal assembly 250, so that the movement 200 forms a relatively integral structure, and also makes the movement 200 as a whole relative to the box 100, so that it can be placed in the box 100 as a whole, such as the shell 110, and can also be taken out of the box 100 as a whole. Such a structural design not only enables the microfluidic portable food safety analyzer 300 to realize the chemiluminescence detection function, which can perform qualitative, semi-quantitative or fully quantitative detection, with a wider detection sensitivity and higher accuracy, but also makes it easy to replace the movement 200, meeting the requirements of easy portability and easy maintenance.

[0050] The centrifugal assembly 250 is configured to carry the disc chip to be tested and is used to process the sample carried by the disc chip by centrifugation; the centrifugal assembly 250 is usually stationary. In one embodiment, the centrifugal assembly 250 is a synchronous belt transmission mechanism, a hollow shaft motor direct drive mechanism or a gear two-stage reduction mechanism. The above are only examples, and the centrifugal assembly 250 is not limited to these mechanisms and other similar transmissions. In one embodiment, the centrifugal assembly 250 is as follows Figure 7 As shown, combined Figure 8 The centrifugal assembly 250 includes a motor 251, a transmission belt 252 and a centrifugal table 253. The centrifugal table 253 is configured to carry the disc chip to be detected. The motor 251 drives the centrifugal table 253 to rotate through the transmission belt 252 to achieve the centrifugal function of the disc chip. In this embodiment, the pressing assembly 230, the heating module and the magnetic module 260 and other functional components are arranged adjacent to the centrifugal table 253. In other embodiments, the centrifugal assembly 250 may also include other structures, and this application does not impose additional restrictions on this. Such a structural design not only realizes chemiluminescence detection, but is also suitable for the detection of disc chips. It can realize the simultaneous detection of multiple items and obtain the detection results of multiple items at one time, thereby meeting the needs of high throughput.

[0051] The optical collection module 220 is positioned at a first preset position adjacent to the disc chip and is used to perform optical collection, such as fluorescence or infrared detection, at or within a certain range of the first preset position. In other words, the first preset position provides an optical collection area. The optical collection module 220 can be fixed or repositioned. Because optical collection is performed directly at the first preset position, there are no complex optical channels or structures, or in other words, no complex optical path design. Consequently, positioning accuracy requirements are relatively low, maintenance is relatively simple, and equipment costs are relatively low.

[0052] In one embodiment, the optical collection module 220 is mounted on the base 270 or below the top housing 210 via a linear guide. A screw motor drives a cam mechanism or a rack-and-pinion structure to drive the linear guide for vertical movement relative to the centrifugal assembly 250. It will be appreciated that the use of the optical collection module 220 utilizes the conventional, universal chemiluminescence detection principle. The embodiments of this application do not involve improvements to the principles or method innovations of the optical collection module 220; they simply utilize the optical collection function of the optical collection module 220. This structural design enables the optical collection module 220 to move up and down relative to the centrifugal assembly 250 and the disc-shaped chip it carries to be detected, thereby achieving a better optical collection position and performing optical collection operations, thereby enabling chemiluminescence detection. Compared to traditional colloidal gold and colorimetric methods, this method can achieve qualitative, semi-quantitative, or fully quantitative detection, with a wider range of detection sensitivity and higher accuracy. Furthermore, due to the lack of a complex optical path design, the positioning accuracy required is relatively reduced, thereby meeting the positioning accuracy requirements and avoiding significant errors in the detection results.

[0053] The heating module is positioned adjacent to a second preset position of the disc chip and is configured to control heating at or within a certain range of the second preset position. Specifically, the second preset position provides a temperature-controlled zone. It is understood that the disc chip can be a complete disc chip or an incomplete disc chip, such as one, two, or multiple disc chips that are at least partially sector-shaped. The first and second preset positions can be set or adjusted based on the specifications of the disc chip. The same applies to the remaining embodiments and is not further elaborated.

[0054] In order to ensure the heating effect and achieve rapid heating and temperature change, in one embodiment, as Figure 5 As shown, the heating module includes an upper heating component 241 disposed under the top shell 210, as shown in FIG. Figure 8As shown, the heating module further includes a lower heating assembly 242 disposed on the base 270, so that the second preset position of the disc chip is located between the upper heating assembly 241 and the lower heating assembly 242; in one embodiment, the upper heating assembly 241 and the lower heating assembly 242 are separately disposed and together constitute the heating module. Such a structural design is conducive to improving the heating and temperature change efficiency. In order to facilitate assembly, further, in one embodiment, as Figure 3 As shown, the top shell 210 includes an upper shell 215 and an upper cover plate 211, the upper shell 215 is covered on the optical collection module 220, the heating module and the centrifugal assembly 250, the optical collection module 220 and the pressing assembly 230 are arranged on the upper cover plate 211, and the heating module is arranged on the upper cover plate 211 or at least partially located in the upper cover plate 211; or, the upper shell 215 is covered on the upper cover plate 211, the optical collection module 220 and the pressing assembly 230 are arranged on the upper cover plate 211, and the heating module is arranged on the upper cover plate 211 or at least partially located in the upper cover plate 211. Furthermore, in one embodiment, the heating module 240 includes an upper heating component 241 and a lower heating component 242, the upper heating component 241 is arranged in the upper cover plate 211 as a first heating module, and the lower heating component 242 is arranged in the centrifugal component 250 as a second heating module.

[0055] Furthermore, in one embodiment, Figure 3 As shown, the movement 200 further includes an upper cover plate 211, a lower cavity 212 and a positioning button 213. The upper cover plate 211 is used to close the gap between the top shell 210 and the lower cavity 212. The positioning button 213 is used to coordinate the positioning installation and fix the top shell 210 to the lower cavity 212. Figure 6 and Figure 8 The core 200 also includes a pot 214. The lower chamber 212 houses the pot 214 and partially accommodates the centrifugal assembly 250. The pot 214 cooperates with the heating module to provide a heating environment for the disc chip or its second predetermined position. This design not only facilitates the formation of a cohesive reaction environment for optical inspection but also forms a cohesive core 200, making replacement and maintenance easier. Furthermore, it offers advantages such as a simple structure, compact size, and light weight, making it easy to carry and maintain.

[0056] In order to facilitate magnetic control of some magnetic adsorption structures in the internal chamber of the disc chip, such as the lysis chamber, in one embodiment, as Figure 6 and Figure 7As shown, the movement 200 further includes a magnetic module 260 disposed on the base 270. The top case 210 is positioned above the magnetic module 260 to cover the magnetic module 260. The magnetic module 260 is positioned at a fourth predetermined position adjacent to the disc chip. The fourth predetermined position may correspond to the location of an internal chamber of the disc chip, such as a lysis chamber, and may also be set or adjusted based on the specifications of the disc chip.

[0057] In actual application, in order to facilitate the adjustment of the position of the magnetic module 260, in one embodiment, the magnetic module 260 is driven by a screw motor, and is moved up and down relative to the centrifugal assembly 250 through a guide shaft and an oil-free bushing mechanism. Alternatively, the magnetic module 260 is driven by a screw motor, and is moved up and down relative to the centrifugal assembly 250 through a guide rail and a synchronous belt mechanism, a rack and pinion mechanism or a cam mechanism. For example, the movement 200 also includes the screw motor, and the magnetic module 260 is installed on the oil-free bushing matched with the guide shaft of the screw motor, so that under the drive of the screw motor, the magnetic module 260 moves up and down relative to the centrifugal assembly 250, thereby achieving approach and distance relative to the disc chip and its fourth preset position, so as to ensure the magnetic adsorption effect of the magnetic adsorption structure carried by the disc chip at the fourth preset position.

[0058] Considering that some of the disc chips have a storage structure, some detection substances are stored in the storage structure, including reaction substances and cleaning substances, etc. The reaction substances can be liquid, powder or solid, and the cleaning substances are usually liquid, so the storage structures are generally collectively referred to as liquid capsules. In one embodiment, the pressing assembly 230 is arranged on the base 270 or under the top shell 210, that is, the movement 200 also includes a pressing assembly 230 arranged on the base 270 or under the top shell 210, that is, the top shell 210 is located above the pressing assembly 230, so as to trigger or start the pressing assembly 230 when the top shell 210 covers the disc chip. The pressing assembly 230 can be enabled directly when the top shell 210 covers the disc chip to realize the release of the detection substance at the corresponding position of the disc chip. The pressing assembly 230 can also be started when the top shell 210 covers the disc chip to start the release operation. The detection substance can be released immediately or slowly, or the detection substance can be released after a certain period of time.

[0059] Furthermore, the pressing assembly 230 is positioned adjacent to a third preset position of the disc chip, so that when the top shell 210 covers the disc chip, the pressing assembly 230 is triggered to press against the disc chip at the third preset position. Specifically, the pressing assembly 230 is configured to release the storage structure at the third preset position of the disc chip under controlled conditions, thereby releasing the detection substance in the storage structure to mix with, for example, react with, the sample or reactant carried by the disc chip. Similarly, the third preset position can correspond to the location of an internal chamber of the disc chip, such as a reaction chamber, a buffer chamber, or an elution chamber, and can also be configured or adjusted according to the specifications of the disc chip. Furthermore, the pressing assembly 230 can be configured to release all detection substances from the storage structure at once, or it can be configured to release various detection substances from the storage structure in multiple stages, such as releasing a cleaning solution first and a substrate solution second.

[0060] Regarding the position distribution of the pressing assembly 230, the heating module and the magnetic module 260, in one embodiment, the pressing assembly 230, the heating module and the magnetic module 260 are respectively arranged around the rotating output shaft of the centrifugal assembly 250; further, the surrounding includes fully surrounding, for example, forming a ring or a circle, such as Figure 6 As shown, the magnetic module 260 completely surrounds the rotating output shaft of the centrifugal assembly 250 to form a ring; the surrounding also includes partially surrounding, for example, forming a partial ring or a partial circle. For an embodiment in which only one pressing assembly 230 is provided, as shown in FIG. Figure 5 As shown, the pressing assembly 230 can be arranged at a position with a certain distance from the rotating output shaft of the centrifugal assembly 250, so that the pressing assembly 230 is set to a third preset position adjacent to the disc chip, thereby releasing the detection substance according to the design plan or detection requirements under certain conditions.

[0061] Considering that different sizes of disc chips may have different liquid capsule thicknesses, to ensure effective release and avoid detection failures, in one embodiment, the press-fit assembly 230 is mounted on the base 270 or under the top shell 210 via a linear guide. A screw motor drives a cam mechanism or a rack-and-pinion structure to drive the linear guide to move up and down relative to the centrifugal assembly 250. This structural design improves the applicability of the microfluidic portable food safety analyzer 300 and ensures the effectiveness of detection results.

[0062] The following combination Figures 1 to 8, a specific application example is given to illustrate the microfluidic portable food safety analyzer 300, which includes a case 100 and a movement 200, the movement 200 includes an upper cover 211, an optical collection module 220, a pressing assembly 230, a heating module, a centrifugal assembly 250, and a magnetic suction module 260, the case 100 includes a shell 110, a touch display screen 160, a heat dissipation assembly 120, a communication unit 130, a handle 140 and a consumables placement area 150, and the case 100 also includes a battery pack located inside the shell 110. The optical collection module 220 and the pressing assembly 230 in the movement 200 are fixed on the top shell 210, and are respectively moved up and down by cam transmission; the heating module includes an upper heating assembly 241 and a lower heating assembly 242. The upper heating assembly 241 is fixed in the top shell 210, and the lower heating assembly 242 is fixed on the outside of the pot body 214 at the lower cavity 212; the centrifugal assembly 250 is installed in the pot body 214 at the lower cavity 212 with the help of a bearing. Through the synchronous belt transmission, the motor 251, i.e., the centrifugal motor, drives the centrifugal table 253 and the disc chip thereon to perform high-speed centrifugal motion; the magnetic attraction module 260 is fixed in the pot body 214 by a guide rod and a sliding sleeve. Other motors drive the magnetic attraction module 260 up and down to achieve the adsorption and cleaning of the magnetic beads inside the disc chip. The working process is to press or manually rotate the positioning button 213 to separate the top shell 210 and the lower cavity 212, open the lower cavity 212, put in the chip reagent disc, i.e. the disc chip, add the sample to the sample port, and then fix the top shell 210. Through laser scanning positioning, the origin position of the reagent disc is determined, and the upper cam motor drives the pressing assembly 230 to successively crush the liquid capsule on the chip disc, i.e. the disc chip, and release the cleaning liquid inside. The centrifugal assembly 250 turns on high-speed centrifugation, goes through three-stage cleaning, and finally releases the substrate liquid in the liquid capsule. During the cleaning process, the magnetic suction module 260 plays an adsorption role on the reaction liquid in the chip disc, so that the antigen and antibody are fully combined. Finally, the optical acquisition module 220 reads the number of photons in the reaction chamber through the PMT, converts the optical signal into an electrical signal, and obtains the concentration value of the antigen or antibody in the reaction liquid. The shell 110 of the box 100 is made of a lightweight polymer material and is molded in one piece. A heat dissipation component 120, a consumables placement area 150 and a communication unit 130 are provided inside. The heat dissipation component 120 provides heat dissipation for the entire machine. The consumables placement area 150 can be used to place structures including a TIP head box and a barcode scanner gun. The communication unit 130 provides signal transmission and reception functions for the entire machine. The built-in battery pack is a 48V battery pack, which can maintain 2 hours of whole-machine testing on a single charge.

[0063] It is understandable that the centrifugal assembly 250 adopts a synchronous belt drive, which can be replaced by other forms, such as a hollow shaft motor direct drive or a gear two-stage reduction and other motion modes. The optical collection module 220 and the pressing assembly 230 can be respectively installed on the base plate through linear guide rails, driven by a screw motor, and rely on a cam mechanism to achieve their own up and down movement; they can also be replaced by other forms, such as a gear rack structure and other motion modes. The magnetic suction module 260 can adopt a nephrite iron boron permanent magnet, or an electromagnet or other magnetic elements. The driving method of the magnetic suction module 260 can adopt a guide shaft with an oil-free bushing, and realize up and down movement through a screw motor drive. It can also be replaced by other motion forms, including but not limited to guide rails with synchronous belts, gear racks, cam mechanisms and other methods.

[0064] It should be noted that other embodiments of the present application also include a microfluidic portable food safety analyzer that can be implemented by combining the technical features in the above embodiments, which can also be called a microfluidic portable detection device or a portable chemiluminescence detection device.

[0065] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0066] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that a person of ordinary skill in the art may make various modifications and improvements without departing from the spirit of the present application, all of which fall within the scope of protection of the present application. Therefore, the scope of patent protection for the present application shall be determined by the appended claims.

Claims

1. A microfluidic portable food safety analyzer (300), characterized in that: It includes a box (100) and a movement (200); The box (100) comprises a shell (110) and an upper cover (170) connected to the shell (110); the movement (200) is detachably arranged in the shell (110); the upper cover (170) is used to cover the shell (110) and expose the movement (200) in an open state; The movement (200) comprises a base (270), a top shell (210) arranged on the base (270), an optical collection module (220), a pressing assembly (230), a heating module, and a centrifugal assembly (250), and the top shell (210) is covered on the optical collection module (220), the pressing assembly (230), the heating module, and the centrifugal assembly (250); The centrifugal assembly (250) is configured to carry a disc chip to be detected, the optical collection module (220) is configured to be located at a first preset position adjacent to the disc chip, and the heating module is configured to be located at a second preset position adjacent to the disc chip; The pressing assembly (230) is arranged on the base (270) or under the top shell (210), and the pressing assembly (230) is arranged at a third preset position adjacent to the disc chip, so as to trigger the pressing assembly (230) to press on the disc chip at the third preset position when the top shell (210) covers the disc chip.

2. The microfluidic portable food safety analyzer (300) according to claim 1, characterized in that: The movement (200) further includes a magnetic module (260) disposed on the base (270), and the top shell (210) is located above the magnetic module (260) to cover the magnetic module (260); The magnetic attraction module (260) is arranged at a fourth preset position adjacent to the disc chip.

3. The microfluidic portable food safety analyzer (300) according to claim 2, characterized in that: The magnetic attraction module (260) is driven by a screw motor and moves up and down relative to the centrifugal assembly (250).

4. The microfluidic portable food safety analyzer (300) according to claim 3, characterized in that: The magnetic attraction module (260) moves up and down relative to the centrifugal assembly (250) under the drive of the screw motor via a guide shaft in conjunction with an oil-free bushing mechanism, or via a guide rail in conjunction with a synchronous belt mechanism, a gear rack mechanism, or a cam mechanism.

5. The microfluidic portable food safety analyzer (300) according to claim 2, characterized in that: The pressing assembly (230), the heating module, and the magnetic attraction module (260) are respectively arranged around the rotating output shaft of the centrifugal assembly (250).

6. The microfluidic portable food safety analyzer (300) according to claim 1, characterized in that: The optical collection module (220) and / or the pressing assembly (230) are mounted on the base (270) or under the top shell (210) via a linear guide rail, and a screw motor is used to drive a cam mechanism or a gear rack structure to drive the linear guide rail to move up and down relative to the centrifugal assembly (250).

7. The microfluidic portable food safety analyzer (300) according to claim 1, characterized in that: The centrifugal assembly (250) is a synchronous belt transmission mechanism, a hollow shaft motor direct drive mechanism, or a gear two-stage reduction mechanism.

8. The microfluidic portable food safety analyzer (300) according to claim 1, characterized in that: The heating module comprises an upper heating component (241) disposed under the top shell (210) and a lower heating component (242) disposed on the base (270), so that the second preset position of the disc chip is located between the upper heating component (241) and the lower heating component (242).

9. The microfluidic portable food safety analyzer (300) according to any one of claims 1 to 8, characterized in that: The box (100) includes a heat dissipation component (120), a communication unit (130), a handle (140), a consumable material placement area (150), and a touch screen display (160); The heat dissipation component (120) is disposed in the housing (110) and / or in the upper cover (170); The communication unit (130) is disposed in the housing (110) or in the upper cover (170); The handle portion (140) is arranged outside the shell (110) or outside the upper cover portion (170); The consumable material placement area (150) is arranged in the housing (110) or in the upper cover (170); The touch display screen (160) is arranged outside the housing (110), outside the upper cover (170), or inside the upper cover (170).

10. The microfluidic portable food safety analyzer (300) according to claim 9, characterized in that: The box (100) further includes a battery assembly, which is detachably disposed in the housing (110) and electrically connected to the communication unit (130) and the touch display screen (160).

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