Cartridge loading driving system and method

Abstract

The embodiment of the invention provides a card box loading driving system and method. The card box loading driving system comprises a base, a driving device and a driving device, the card box tray is mounted on the base in a sliding manner, and the card box tray is used for placing a card box for accommodating a reagent; the card box end side driving structure is fixedly mounted on the base, and the card box end side driving structure comprises driving equipment for treating a reagent and / or a sample; wherein when the card box is placed at the placing position of the card box tray, the card box tray moves towards the card box end side driving structure under the control of the card box end side driving structure, and when the card box tray reaches a preset target position, the card box and the card box end side driving structure are in paired connection. According to the card box loading driving system provided by the embodiment of the invention, the card box loading efficiency is improved.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of motor drive technology, and specifically to a card box loading drive system and method. Background Art

[0002] The cartridge is a container for storing and processing reagents and / or samples. When processing the reagents and / or samples stored in the cartridge, the cartridge needs to be paired with a driving device for processing the reagents. This process is called cartridge loading, so that the reagents and / or samples in the cartridge can be processed automatically later.

[0003] Currently, manual intervention is required for loading the cartridge, for example, the cartridge needs to be manually moved to a position where it is paired with a driving device for processing reagents. This method of loading the cartridge requires manual operation to move the cartridge, which is inefficient. Therefore, how to provide a technical solution to improve the efficiency of cartridge loading has become an urgent problem to be solved by those skilled in the art. Summary of the invention

[0004] In view of this, an embodiment of the present application provides a cartridge loading drive system and method to improve the efficiency of cartridge loading.

[0005] To achieve the above objectives, the embodiments of the present application provide the following technical solutions.

[0006] In a first aspect, an embodiment of the present application provides a cartridge loading drive system, comprising:

[0007] Base;

[0008] A cartridge tray, the cartridge tray being slidably mounted on the base, and the cartridge tray being used to place a cartridge containing a reagent;

[0009] A cartridge end side drive structure, the cartridge end side drive structure is fixedly mounted on the base, the cartridge end side drive structure comprises a drive device for processing reagents and / or samples;

[0010] Among them, when the card box is placed at the placement position of the card box tray, the card box tray moves toward the card box end side driving structure under the control of the card box end side driving structure, and when the card box tray reaches the preset target position, the card box is paired and connected with the card box end side driving structure.

[0011] Optionally, the card box tray includes:

[0012] A driving motor, the driving motor being mounted on a side of the cartridge tray close to the cartridge end side driving structure;

[0013] belt;

[0014] Wherein, the driving motor, under the control of the cartridge end side driving structure, rotates the belt through the shaft of the driving motor and the pulley, so that the cartridge tray moves toward the cartridge end side driving structure.

[0015] Optionally, the card box tray further comprises: a position sensor, the position sensor being used to detect the position of the card box tray;

[0016] Wherein, the card box end side driving structure controls the movement of the card box tray based on the position of the card box tray.

[0017] Optionally, the position sensor includes a first position sensor and a second position sensor; the first position sensor is arranged at the head end of the base, and the second position sensor is arranged at the end end of the base;

[0018] The end is an end of the card box tray close to the card box end side driving structure, and the head end is an end of the card box tray away from the card box end side driving structure.

[0019] Optionally, the first position sensor is used to detect the moving starting point position of the cartridge tray; the second position sensor is used to detect the hard point position of the cartridge tray, and the hard point position is the preset target position;

[0020] Wherein, when the position of the card box tray reaches the hard point position, the card box end side driving structure controls the card box tray to stop moving.

[0021] Optionally, the cartridge end-side driving structure further includes:

[0022] Motor for pairing;

[0023] A rotating drive shaft, wherein the rotating drive shaft is driven by the pairing motor to perform rotational pairing with the card box;

[0024] a pump driving rod, wherein the pump driving rod is moved by the driving of the pairing motor;

[0025] A Hall sensor is used to detect the position of the rotating drive shaft.

[0026] Optionally, there are multiple rotating drive shafts and multiple Hall sensors; wherein, on the bracket of the cartridge end side drive structure, one rotating drive shaft corresponds to one Hall sensor.

[0027] Optionally, the cartridge end-side driving structure further includes:

[0028] A circuit board is arranged above the card box end side driving structure; the circuit board is used for signal transmission between electronic components of the card box loading driving system.

[0029] Optionally, the cartridge comprises at least a pipette tip, a pipette tip box and a pipette pump;

[0030] Among them, when the card box is paired with the card box end side driving structure, the driving rod of the pipette tip is moved in the Z direction of the pipette tip to be paired with the rotating driving shaft; the driving rod of the pipette tip box is moved in the Y direction of the pipette tip box to be paired with the rotating driving shaft; the pump driving rod is moved to the side close to the pipette pump to be paired with the piston push rod of the pipette pump.

[0031] Optionally, the rotary drive shaft comprises: a magnet, a spring and a matching slot; the magnet and the spring are arranged inside the rotary drive shaft, and the matching slot is arranged at the end of the rotary drive shaft.

[0032] Optionally, when the card box is paired with the card box end-side driving structure, the driving rod of the pipette tip and the driving rod of the pipette tip box are first paired with the matching card slot.

[0033] Optionally, before the first pairing connection is performed, the magnet is away from the Hall sensor corresponding to the rotating drive shaft; when the first pairing connection is successful, the magnet moves toward the side close to the pairing motor, and the spring is compressed, and the Hall sensor corresponding to the rotating drive shaft detects the magnet; when the first pairing connection is unsuccessful, the Hall sensor corresponding to the rotating drive shaft does not detect the magnet, and the rotating drive shaft is controlled to rotate so that the driving rod of the pipette tip and the driving rod of the pipette tip box perform the first pairing connection with the pairing slot again.

[0034] Optionally, when the cartridge is paired with the cartridge end-side drive structure, the piston push rod of the liquid transfer pump is second paired with the pump drive rod;

[0035] Before the second pairing connection is performed, the piston of the pipetting pump of the cartridge and the pump driving rod of the cartridge end side driving structure have an initial gap; when the second pairing connection is performed, the pump driving rod moves toward the side close to the piston to eliminate the initial gap, and the pump driving rod pushes the piston to move toward the side away from the cartridge end side driving structure and to the extreme position, wherein the extreme position is the position where the piston cannot move further.

[0036] Optionally, when moving to the extreme position, the pump drive rod maintains contact with the piston; when the driving device needs to absorb reagent, the pairing motor absorbs the reagent by the required volume and drives the pump drive rod to retreat to move toward the side where the card box end side drive structure is located; when the driving device needs to push out the reagent, the pairing motor pushes out the liquid by the required volume and drives the pump drive rod to move toward the side away from the card box end side drive structure.

[0037] In a second aspect, an embodiment of the present application provides a cartridge loading and driving method, which is applied to a controller, comprising:

[0038] When the card box is placed at the placement position of the card box tray, a drive control instruction is output, wherein the drive control instruction is used to control the card box tray to move toward the card box end side drive structure;

[0039] When it is detected that the cartridge tray reaches a preset target position, a drive stop instruction is output, wherein the drive stop instruction is used to control the cartridge tray to stop moving;

[0040] Wherein, after the card box tray reaches a preset target position, the card box is matched and connected with the card box end-side driving structure.

[0041] An embodiment of the present application provides a cartridge loading drive system, which includes: a base; a cartridge tray, which is slidably mounted on the base and is used to place a cartridge containing a reagent; and a cartridge end side drive structure, which is fixedly mounted on the base and includes a drive device for processing reagents and / or samples.

[0042] Since the driving device for processing reagents and / or samples is located in the cartridge end-side driving structure, the cartridge loading driving system provided in the embodiment of the present application needs to pair and connect the cartridge with the cartridge end-side driving structure when loading the cartridge; in order to achieve the pairing and connection between the cartridge and the cartridge end-side driving structure, the cartridge end-side driving structure can be configured with the ability to control the movement of the cartridge tray, and when the cartridge tray is configured to move to a preset target position, the cartridge and the cartridge end-side driving structure can be paired and connected. Based on this, when the cartridge is placed at the placement position of the cartridge tray, the cartridge tray can move toward the cartridge end-side driving structure under the control of the cartridge end-side driving structure, so that when the cartridge tray reaches the preset target position, the cartridge is paired and connected with the cartridge end-side driving structure.

[0043] It can be seen that the cartridge loading drive system provided in the embodiment of the present application is provided by slidingly installing the cartridge tray on the base, and fixing the cartridge end-side drive structure on the base, so that when the cartridge is placed in the placement position of the cartridge tray, the cartridge end-side drive structure can control the cartridge tray to move toward the cartridge end-side drive structure, and when the cartridge tray reaches the preset target position, the cartridge is paired with the cartridge end-side drive structure. Therefore, the embodiment of the present application can realize automated cartridge loading through the setting relationship and mutual cooperation between the base, the cartridge tray, and the cartridge end-side drive structure, reduce the manual operation of the cartridge loading process, and improve the efficiency of cartridge loading. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0045] Figure 1 is a structural diagram of a cartridge loading drive system according to an embodiment of the present application;

[0046] Figure 2 is a structural example diagram of a card box tray according to an embodiment of the present application;

[0047] Figure 3 is a partially enlarged example diagram of a position sensor according to an embodiment of the present application;

[0048] Figure 4 is an example diagram of a cartridge end-side driving structure of an embodiment of the present application;

[0049] Figure 5 This is a structural example diagram of a card box according to an embodiment of the present application;

[0050] Figure 6 This is a pairing example diagram of the cartridge end-side drive structure of an embodiment of the present application;

[0051] Figure 7 is a structural example diagram of a rotating drive shaft according to an embodiment of the present application;

[0052] Figure 8 is a pairing example diagram of the rotating drive shaft of an embodiment of the present application;

[0053] Fig. 9 is an example diagram of pairing a cartridge transfer pump and a pump drive rod according to an embodiment of the present application;

[0054] Fig.10 It is a flow chart of the card box loading and driving method according to an embodiment of the present application. DETAILED DESCRIPTION

[0055] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0056] Cartridge loading is the process of installing a cartridge already loaded with reagents into a drive device for processing specific reagents and / or samples, during which the cartridge and the drive device need to be paired. One way to achieve cartridge loading may be to manually move the cartridge to a position for pairing with the drive device. Although the above implementation method can achieve cartridge loading, it requires manual participation, wastes a lot of labor, and is inefficient. In addition, during the manual participation process, there may be human subjective factors that lead to cartridge loading failure, affecting the subsequent reagent processing process.

[0057] In view of this, an embodiment of the present application provides a card box loading drive system, which realizes automated card box loading through the setting relationship and mutual coordination between various structures within the card box loading drive system, thereby reducing manual participation in the card box loading process and achieving the purpose of improving the card box loading efficiency.

[0058] Figure 1 This is a structural diagram of the card box loading drive system of the embodiment of the present application, refer to Figure 1 The card box loading drive system may include: a base 1, a card box tray 2, and a card box end side drive structure 3.

[0059] The cartridge tray 2 is slidably mounted on the base 1 , and the cartridge tray 2 is used to place a cartridge 4 containing a reagent.

[0060] The card box end side drive structure 3 is fixedly mounted on the base 1; the card box end side drive structure 3 is a structure with motor control capability (for example, the card box end side drive structure may include a drive device for processing reagents and / or samples), and is located on one side (i.e., the end side) relative to the card box 4 in the card box loading drive system.

[0061] When loading the card box, the card box can be placed in the placement position of the card box tray, so that when the card box is placed in the placement position of the card box tray, based on the motor control capability of the card box end side drive structure, the card box tray can move toward the card box end side drive structure under the control of the card box end side drive structure, and when the card box tray reaches the preset target position, the card box is paired and connected with the card box end side drive structure.

[0062] The preset target position can be regarded as the preset position where the card box is paired with the drive device.

[0063] In the embodiment of the present application, since the driving device for processing reagents and / or samples is located in the cartridge end-side driving structure, the cartridge loading driving system provided in the embodiment of the present application needs to pair and connect the cartridge with the cartridge end-side driving structure when loading the cartridge; in order to achieve the pairing and connection between the cartridge and the cartridge end-side driving structure, the cartridge end-side driving structure can be configured with the ability to control the movement of the cartridge tray, and when the cartridge tray is configured to move to a preset target position, the cartridge and the cartridge end-side driving structure can be paired and connected. Based on this, when the cartridge is placed at the placement position of the cartridge tray, the cartridge tray can move toward the cartridge end-side driving structure under the control of the cartridge end-side driving structure, so that when the cartridge tray reaches the preset target position, the cartridge is paired and connected with the cartridge end-side driving structure.

[0064] The cartridge loading drive system provided in the embodiment of the present application is provided by slidingly installing the cartridge tray on the base, and fixing the cartridge end side drive structure on the base, so that when the cartridge is placed in the placement position of the cartridge tray, the cartridge end side drive structure can control the cartridge tray to move toward the cartridge end side drive structure, and when the cartridge tray reaches the preset target position, the cartridge is paired with the cartridge end side drive structure. Therefore, the embodiment of the present application can realize automatic cartridge loading through the setting relationship and mutual cooperation between the base, the cartridge tray, and the cartridge end side drive structure, reduce the manual operation of the cartridge loading process, and improve the efficiency of cartridge loading.

[0065] In an optional implementation, Figure 2 The structure of the card tray of the embodiment of the present application is shown as an example. Figure 2 The card box tray may include: a driving motor 21 and a belt 22.

[0066] In an optional embodiment, the driving motor is a driving stepping motor, and the belt is a timing belt.

[0067] A stepper motor is a type of electric motor, which is characterized by rotating in a certain step length according to an input electric pulse signal. The driving function of the stepper motor can be realized by a special driving circuit and a controller, which is used to achieve accurate position control and motion control. Therefore, the driving stepper motor is arranged in the structure of the cartridge tray, which can achieve more accurate control of the moving position and movement of the cartridge tray. Among them, the driving stepper motor is installed on the side of the cartridge tray close to the cartridge end side driving structure.

[0068] The timing belt is an elastic belt-like transmission element characterized by evenly spaced teeth that precisely engage the driving wheel or driven wheel (the driven wheel, for example, Figure 2 The timing pulley 23 in the cartridge tray is slotted into the slot on the timing pulley 23 to achieve reliable power transmission and transmission synchronization. The timing pulley is used to connect the driving stepper motor and the timing belt to ensure a stable connection between the driving stepper motor and the timing belt, so that the driving stepper motor can stably drive the timing belt. In addition, the timing pulley also has a supporting and guiding function to help maintain the stable operation of the timing belt. Therefore, the timing pulley is arranged in the structure of the cartridge tray to ensure the stability and reliability of the entire cartridge loading drive system.

[0069] In a specific example, the driving stepper motor can be controlled by the cartridge end side driving structure to rotate through the shaft of the driving stepper motor and the timing pulley, and the timing belt can move the cartridge tray toward the cartridge end side driving structure. For example, when the cartridge needs to be loaded and the cartridge is paired with the cartridge end side driving structure, the cartridge tray can be controlled to move toward the cartridge end side driving structure.

[0070] In another optional example, the driving stepper motor, under the control of the cartridge end side driving structure, rotates the timing belt through the shaft of the driving stepper motor and the timing pulley, so that the cartridge tray moves away from the cartridge end side driving structure. For example, when the cartridge needs to be removed from the cartridge loading drive system, the cartridge tray can be controlled to move away from the cartridge end side driving structure. It should be noted that Figure 2 The direction of the arrow shown in is an example of the direction when the cartridge tray moves away from the cartridge end side drive structure.

[0071] In an optional implementation, the cartridge tray may further include a position sensor 24, see Figure 3 The position sensor 24 is a partially enlarged example diagram. The position sensor is a sensor that can sense the position of the object to be measured and convert it into a usable output signal, which is used to detect the position of the cartridge tray. The cartridge end side drive structure can control the movement of the cartridge tray based on the position of the cartridge tray.

[0072] In a specific example, referring specifically to Figure 3 The position sensor 24 includes a first position sensor 241 and a second position sensor 242; the first position sensor is arranged at the head end of the base, and the second position sensor is arranged at the tail end of the base. The tail end is the end of the cartridge tray close to the cartridge end side driving structure, and the head end is the end of the cartridge tray away from the cartridge end side driving structure.

[0073] Position sensors are respectively arranged at the head and tail ends of the base to detect the travel position of the card box tray. The controller of the card box loading drive system can send instructions (for example, control the driving motor to continue moving, or stop driving the driving motor) according to the position detection signal received from the position sensor.

[0074] Furthermore, the first position sensor is used to detect the starting position of the movement of the cartridge tray, and the second position sensor is used to detect the hard point position of the cartridge tray; it should be noted that the hard point position is a preset target position. When the position of the cartridge tray reaches the hard point position, the cartridge end side drive structure can control the cartridge tray to stop moving, and when the first position sensor detects that the cartridge tray moves to the starting position, the cartridge loading drive system can also control the cartridge tray to stop moving.

[0075] When the card cartridge tray is located at the starting position of movement, at this time, the user can operate the control button (optionally, the control button can be set on the operation panel of the card cartridge loading drive system), thereby instructing the card cartridge loading drive system to control the card cartridge tray to move toward the card cartridge end side drive structure, so that the card cartridge tray drives the card cartridge to move toward the card cartridge end side drive structure; when the card cartridge tray moves to the hard point position, the second position sensor detects that the card cartridge tray is located at the hard point position and outputs a position detection signal, at this time, the card cartridge loading drive system judges that the card cartridge has reached the pairing position based on the position detection signal of the second position sensor, thereby controlling to stop the movement of the card cartridge tray, that is, the card cartridge end side drive structure controls the card cartridge tray to stop moving.

[0076] In an optional implementation, Figure 4 An exemplary diagram showing the end-side drive structure of the cartridge of the present application is shown. Figure 4 The cartridge end side driving structure may include a pairing motor 31 , a rotating driving shaft 32 , a pump driving rod 33 , and a Hall sensor 34 .

[0077] In a specific example, the pairing motor is a pairing stepping motor. The stepping motor can rotate according to a certain step length according to the input electrical pulse signal, so as to realize accurate position control and motion control. The pairing stepping motor is arranged in the cartridge end side driving structure, and can be used to drive and control the rotating driving shaft and the pump driving rod in the cartridge end side driving structure to pair with the cartridge.

[0078] The rotary drive shaft is a mechanical component that drives or rotates an axis to rotate, and is used for the cartridge end side drive structure to connect and mate with the cartridge;

[0079] The pump driving rod is an important connecting component between the pairing stepping motor and the liquid transfer pump of the cartridge. The pairing stepping motor can drive the pump driving rod to connect and pair with the cartridge, thereby performing liquid transfer.

[0080] The Hall sensor is a component that uses magnetic force to feed back the position information of an object to the controller. It is a position detection sensor.

[0081] In an optional embodiment, the rotating drive shaft 32 is driven by the pairing motor 31 to rotationally pair with the card box 4; the pump drive rod 33 is driven by the pairing motor to move; and the Hall sensor 34 is used to detect the position of the rotating drive shaft.

[0082] In an optional implementation, in the cartridge end side drive structure, there are multiple rotation drive shafts and multiple Hall sensors; on the bracket of the cartridge end side drive structure, one rotation drive shaft corresponds to one Hall sensor. A Hall sensor is provided corresponding to each rotation drive shaft, and the position of each rotation drive shaft is detected, so that it can be confirmed in time whether each rotation drive shaft is successfully paired.

[0083] In an optional implementation, combined with Figure 4 As shown, the cartridge end side driving structure may further include: a circuit board 35, wherein the circuit board is disposed above the cartridge end side driving structure.

[0084] The circuit board, also known as a printed circuit board, is used to connect and support electronic components (such as the Hall sensor 34, the position sensor 24, and the controller in the cartridge loading drive system) and provide electrical connections between the electronic components. The wiring and tracking design on the circuit board provides electrical connections between the various electronic components and between the external power supply and / or the controller, so that signals and power can be transmitted between the electronic components. In an optional example, the circuit board can be used for signal transmission between the electronic components of the cartridge loading drive system.

[0085] In an optional implementation, Figure 5 The structural diagram of the card box of the embodiment of the present application is shown as an example. Figure 5 The card box at least includes: a pipette tip 41, a pipette tip box 42, and a pipette pump 43.

[0086] The pipette tip is a type of pipette, used to conveniently and accurately transfer reagent liquid; one end of the pipette tip 41 is connected to the pipette pump 43, and the other end is used to absorb and release liquid. The pipette tip box is a structure for storing and protecting the pipette tip. The pipette pump is a pipetting tool used to control the capacity and flow rate of the pipette, and can provide an accurate volume of the pipette. The pipette pump can control the volume and flow rate of the pipette, and the pipette tip is used to absorb and release the pipette. Using the two together can make the pipetting operation more convenient and accurate.

[0087] In an alternative embodiment, Figure 6 An exemplary diagram of the pairing of the card box end side drive structure is shown, combined with Figure 4 , Figure 5 and Figure 6 ,based on Figure 6 In the three-dimensional spatial directions of X, Y and Z shown, when the cartridge is paired with the cartridge end-side drive structure, the pipette tip moves the drive rod of the pipette tip in the Z direction to be paired with the rotating drive shaft; the pipette tip box moves the drive rod of the pipette tip box in the Y direction to be paired with the rotating drive shaft; the pump drive rod moves to the side close to the pipette pump to be paired with the piston push rod of the pipette pump. It should be noted that the dotted line in the figure represents the paired connection relationship between the cartridge end-side drive structure and the cartridge.

[0088] In an optional implementation, Figure 7 The structure of the rotating drive shaft is shown as an example. Figure 7 The rotating drive shaft includes: a magnet 321, a spring 322, and a matching slot 323;

[0089] The magnet is used for the Hall sensor to detect the position of the rotating drive shaft. When the Hall sensor detects the magnet, it detects the position of the rotating drive shaft. The spring is used to provide resilience and buffer vibration when the rotating drive shaft is paired with the card box, which can achieve flexible connection and maintain a tight connection, thereby enhancing the stability, adaptability and reliability of the pairing structure. The pairing slot can provide accurate positioning and alignment functions to ensure that the drive rod of the pipette tip of the card box and the drive rod of the pipette tip box are accurately paired and connected with the rotating drive shaft. The pairing slot plays an important connecting and supporting role in the pairing structure.

[0090] In a specific example, the magnet and the spring are arranged inside the rotation drive shaft, and the matching slot is arranged at the end of the rotation drive shaft.

[0091] In an optional implementation, when the card box is paired with the card box end-side driving structure, the driving rod of the pipette tip and the driving rod of the pipette tip box are first paired with the matching card slot.

[0092] When the card box is paired with the card box end drive structure, the pairing slot at the end of the rotating drive shaft needs to be paired with each drive rod of the card box. This process mainly uses the Hall sensor to detect whether the pairing connection is completed. When the drive rod of the card box is successfully paired with the pairing slot, the magnet in the rotating drive shaft will be detected by the Hall sensor; if the Hall sensor does not detect the magnet, that is, the drive rod of the card box is not paired with the pairing slot, the rotating drive shaft is controlled to rotate so that the drive rod of the card box is paired with the pairing slot again.

[0093] In an alternative embodiment, Figure 8 The example diagram of the pairing of the rotating drive shaft is shown as an example. Figure 8 Before the first pairing connection is performed, the magnet 321 is away from the Hall sensor corresponding to the rotating drive shaft; when the first pairing connection is successful, the magnet 321 moves toward the side close to the pairing motor, and the spring 322 is compressed, and the Hall sensor corresponding to the rotating drive shaft detects the magnet; when the first pairing connection is unsuccessful, refer to Figure 8 The Hall sensor corresponding to the rotating drive shaft does not detect the magnet 321, and the rotating drive shaft is controlled to rotate so that the driving rod of the pipette tip or the driving rod of the pipette tip box and the pairing slot 323 perform the first pairing connection again.

[0094] It should be noted that Figure 8 The arrow direction in the figure is the rotation direction and movement direction of the rotary drive shaft.

[0095] In an optional implementation, when the cartridge is paired with the cartridge end side drive structure, the piston push rod of the pipette pump is second paired with the pump drive rod. When the cartridge is paired with the cartridge end side drive structure, the pump drive rod needs to be paired with the piston push rod of the pipette pump to determine the initial position of the pump drive rod before the pipetting operation.

[0096] Based on this, in an optional embodiment, before the second pairing connection is performed, the piston of the pipetting pump of the card box and the pump drive rod of the card box end side drive structure have an initial gap; when the second pairing connection is performed, the pump drive rod moves toward the side close to the piston to eliminate the initial gap, and the pump drive rod pushes the piston to move toward the side away from the card box end side drive structure and moves to the extreme position, and the extreme position is the position where the piston cannot continue to move (i.e., the initial position of the pump drive rod before starting the pipetting operation).

[0097] In a specific example, Fig. 9The exemplary diagram of the pairing of the cartridge transfer pump and the pump drive rod is shown in FIG. Fig. 9 Before the pump driving rod 33 is paired and connected, there is an initial gap 901 between the cartridge pipetting pump and the pump driving rod 33. Assuming that the value of the initial gap is a, the pump driving rod 33 moves toward the piston 431 of the pipetting pump and first moves a+b to eliminate the initial gap; where b is the value of the error gap. Then, the piston is pushed to move to the side away from the cartridge end side drive structure (i.e., the direction of the bold arrow shown in the figure) until the piston cannot move further, which is the limit position. This position is also the initial position of the pump driving rod before the pipetting operation.

[0098] Furthermore, when moving to the extreme position, the pump drive rod maintains contact with the piston; when the driving device needs to absorb reagent, the matching motor absorbs the reagent by the required volume and drives the pump drive rod to retreat to move toward the side where the cartridge end drive structure is located; when the driving device needs to push out the reagent, the matching motor pushes out the liquid by the required volume and drives the pump drive rod to move toward the side away from the cartridge end drive structure.

[0099] In a specific example, when the piston moves to the limit, the pump drive rod is kept in contact with the piston; when the driving device needs to absorb the reagent, the paired motor drives the pump drive rod to retreat, and the retreat direction is close to the side where the cartridge end drive structure is located; optionally, the retreat distance includes the initial gap and the distance corresponding to the volume of the reagent to be absorbed. When the driving device needs to push out the reagent, the paired motor drives the pump drive rod to move away from the cartridge end drive structure, and the movement direction is Fig. 9 Optionally, the moving distance at least includes the distance corresponding to the volume of the reagent to be drawn.

[0100] The following is an introduction to the cartridge loading drive method of the embodiment of the present application from the perspective of the controller. The cartridge loading drive method described below can be considered as a control process executed by the controller when implementing cartridge loading. The cartridge loading drive method described below can be referenced to the contents of the cartridge loading drive system described above.

[0101] Optional, Fig.10 A flowchart of a cartridge loading and driving method provided in an embodiment of the present application is shown, which is applied to a controller. The controller can be arranged in a cartridge end-side driving structure. Fig.10 , the card box loading drive method may include:

[0102] Step S1001: when the card box is placed at the placement position of the card box tray, a drive control instruction is output;

[0103] Wherein, the drive control instruction is used to control the card box tray to move toward the card box end side drive structure.

[0104] Step S1002: when it is detected that the cartridge tray reaches a preset target position, outputting a drive stop instruction;

[0105] Wherein, the drive stop instruction is used to control the card box tray to stop moving; after the card box tray reaches a preset target position, the card box is paired and connected with the card box end-side drive structure.

[0106] It can be seen that the cartridge loading drive system provided in the embodiment of the present application is provided by slidingly installing the cartridge tray on the base, and fixing the cartridge end-side drive structure on the base, so that when the cartridge is placed in the placement position of the cartridge tray, the cartridge end-side drive structure can control the cartridge tray to move toward the cartridge end-side drive structure, and when the cartridge tray reaches the preset target position, the cartridge is paired with the cartridge end-side drive structure. Therefore, the embodiment of the present application can realize the automatic loading of the cartridge through the setting relationship and mutual cooperation between the base, the cartridge tray, and the cartridge end-side drive structure, reduce the manual operation of the cartridge loading process, and improve the efficiency of the cartridge loading.

[0107] The above describes multiple implementation schemes provided by the embodiments of the present application. The various optional methods introduced in each implementation scheme can be combined and cross-referenced with each other without conflict, thereby extending a variety of possible implementation schemes, which can all be considered as implementation schemes disclosed and open in the embodiments of the present application.

[0108] Although the embodiments of the present application are disclosed above, the present application is not limited thereto. Any person skilled in the art may make various changes and modifications without departing from the spirit and scope of the present application. Therefore, the scope of protection of the present application shall be subject to the scope defined by the claims.

Claims

1. A cartridge loading drive system, characterized in that: include: Base; A cartridge tray, the cartridge tray being slidably mounted on the base, and the cartridge tray being used to place a cartridge containing a reagent; A cartridge end side drive structure, the cartridge end side drive structure is fixedly mounted on the base, the cartridge end side drive structure comprises a drive device for processing reagents and / or samples; Among them, when the card box is placed at the placement position of the card box tray, the card box tray moves toward the card box end side driving structure under the control of the card box end side driving structure, and when the card box tray reaches the preset target position, the card box is paired and connected with the card box end side driving structure.

2. The cartridge loading drive system according to claim 1, characterized in that: The card box tray comprises: A driving motor, the driving motor being mounted on a side of the cartridge tray close to the cartridge end side driving structure; belt; Wherein, the driving motor, under the control of the cartridge end side driving structure, rotates the belt through the shaft of the driving motor and the pulley, so that the cartridge tray moves toward the cartridge end side driving structure.

3. The cartridge loading drive system according to claim 2, characterized in that: The card box tray further comprises: a position sensor, the position sensor being used to detect the position of the card box tray; Wherein, the card box end side driving structure controls the movement of the card box tray based on the position of the card box tray.

4. The cartridge loading drive system according to claim 3, characterized in that: The position sensor comprises a first position sensor and a second position sensor; the first position sensor is arranged at the head end of the base, and the second position sensor is arranged at the end end of the base; The end is an end of the card box tray close to the card box end side driving structure, and the head end is an end of the card box tray away from the card box end side driving structure.

5. The cartridge loading drive system according to claim 4, characterized in that: The first position sensor is used to detect the moving starting point position of the cartridge tray; the second position sensor is used to detect the hard point position of the cartridge tray, and the hard point position is the preset target position; Wherein, when the position of the card box tray reaches the hard point position, the card box end side driving structure controls the card box tray to stop moving.

6. The cartridge loading drive system according to any one of claims 1 to 5, characterized in that: The cartridge end side driving structure further comprises: Motor for pairing; A rotating drive shaft, wherein the rotating drive shaft is driven by the pairing motor to perform rotational pairing with the card box; a pump driving rod, wherein the pump driving rod is moved by the driving of the pairing motor; A Hall sensor is used to detect the position of the rotating drive shaft.

7. The cartridge loading drive system according to claim 6, characterized in that: There are multiple rotating drive shafts and multiple Hall sensors; wherein, on the bracket of the cartridge end side driving structure, one rotating drive shaft corresponds to one Hall sensor.

8. The cartridge loading drive system according to claim 7, characterized in that: The cartridge end side driving structure further comprises: A circuit board is arranged above the card box end side driving structure; the circuit board is used for signal transmission between electronic components of the card box loading driving system.

9. The cartridge loading drive system according to claim 7, characterized in that: The card box at least includes a pipette tip, a pipette tip box and a pipette pump; Among them, when the card box is paired with the card box end side driving structure, the driving rod of the pipette tip is moved in the Z direction of the pipette tip to be paired with the rotating driving shaft; the driving rod of the pipette tip box is moved in the Y direction of the pipette tip box to be paired with the rotating driving shaft; the pump driving rod is moved to the side close to the pipette pump to be paired with the piston push rod of the pipette pump.

10. The cartridge loading drive system according to claim 9, characterized in that: The rotary drive shaft comprises: a magnet, a spring and a matching slot; the magnet and the spring are arranged inside the rotary drive shaft, and the matching slot is arranged at the end of the rotary drive shaft.

11. The cartridge loading drive system according to claim 10, characterized in that: When the card box is mated and connected with the card box end-side driving structure, the driving rod of the pipette tip and the driving rod of the pipette tip box are first mated and connected with the mating card slot.

12. The cartridge loading drive system according to claim 11, characterized in that: Before the first pairing connection is performed, the magnet is away from the Hall sensor corresponding to the rotating drive shaft; when the first pairing connection is successful, the magnet moves to the side close to the pairing motor, and the spring is compressed, and the Hall sensor corresponding to the rotating drive shaft detects the magnet; when the first pairing connection is unsuccessful, the Hall sensor corresponding to the rotating drive shaft does not detect the magnet, and the rotating drive shaft is controlled to rotate so that the driving rod of the pipette tip and the driving rod of the pipette tip box perform the first pairing connection with the pairing slot again.

13. The cartridge loading drive system according to claim 9, characterized in that: When the cartridge is mated with the cartridge end-side drive structure, the piston push rod of the liquid transfer pump is second mated with the pump drive rod; Before the second pairing connection is performed, the piston of the pipetting pump of the cartridge and the pump driving rod of the cartridge end side driving structure have an initial gap; when the second pairing connection is performed, the pump driving rod moves toward the side close to the piston to eliminate the initial gap, and the pump driving rod pushes the piston to move toward the side away from the cartridge end side driving structure and to the extreme position, wherein the extreme position is the position where the piston cannot move further.

14. The cartridge loading drive system according to claim 13, characterized in that: When moving to the extreme position, the pump drive rod maintains contact with the piston; when the driving device needs to absorb reagent, the matching motor absorbs the reagent by the required volume and drives the pump drive rod to retreat to move toward the side where the cartridge end side driving structure is located; when the driving device needs to push out reagent, the matching motor pushes out the liquid by the required volume and drives the pump drive rod to move toward the side away from the cartridge end side driving structure.

15. A cartridge loading and driving method, characterized in that: Applied to a controller, the cartridge loading drive method comprises: When the card box is placed at the placement position of the card box tray, a drive control instruction is output, wherein the drive control instruction is used to control the card box tray to move toward the card box end side drive structure; When it is detected that the cartridge tray reaches a preset target position, a drive stop instruction is output, wherein the drive stop instruction is used to control the cartridge tray to stop moving; Wherein, after the card box tray reaches a preset target position, the card box is matched and connected with the card box end-side driving structure.

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