X-ray imaging plate for pixelated isolation of optical crosstalk and application of X-ray imaging plate
By using rare earth doped nanoscintifiers and photochromic molecules in X-ray imaging plates, the problem of weak light scattering and absorption in traditional X-ray imaging technology is solved, and high-resolution imaging and visual imaging are achieved, with reusability and efficient information storage capabilities.
Patent Information
- Application Number
- CN202411805886.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-04-15
AI Technical Summary
Traditional X-ray imaging scintillation screens have light scattering problems, which makes it difficult to balance resolution and brightness, and organic photochromic materials have weak absorption and poor response to X-rays, which limits their application in X-ray imaging.
The pixelated structure of the optical fiber panel is filled with rare earth doped nanoscintels and covered with a layer of photochromic molecules. The X-ray imaging plate formed can effectively reduce light interference, achieve high-resolution imaging, and solve the problem of weak X-ray absorption of photochromic molecules through the strong absorption capacity of rare earth doped nanoscintels.
It realizes high-resolution imaging of fine structures and visual imaging of objects, solves the problems of weak light scattering and absorption in traditional X-ray imaging technology, and has reusability and efficient information storage capabilities.
Smart Images
Figure CN119828197A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of X-ray imaging in optical imaging, and in particular to an X-ray imaging plate for pixelated isolation of optical crosstalk and application thereof. Background Art
[0002] As the mainstream choice in the current market, scintillator-based X-ray imaging detectors play an important role in scientific research and real-world applications such as medical imaging diagnosis, food and device quality inspection, and safety monitoring. A relevant example of X-ray imaging scintillators is non-destructive testing in the huge and rapidly developing market of microelectronic components. In this case, the diameter of the bonding wires in electronic chips is usually less than 30 μm, which requires scintillators with sufficiently high spatial resolution to identify such fine structural features. In general, in order to balance the spatial resolution of X-ray imaging and the scintillation brightness, it is desirable to maintain low lateral light crosstalk on a sufficiently thick scintillator screen. However, traditional scintillator screens composed of polycrystals with non-oriented crystal structures inevitably have inherent light scattering problems. Although the development of nanoscale emitters has alleviated light scattering, this problem still exists and worsens as the thickness of the scintillator screen increases. Therefore, the contradiction between scintillator thickness and high resolution remains a huge challenge in X-ray imaging related applications. In order to effectively solve this challenge, a core idea is to develop pixelated array scintillators, which make the scintillation photons propagate in the vertical direction to weaken unwanted lateral photon leakage, or guide the photons to be fully reflected in a specified space.
[0003] Simplifying X-ray imaging and enabling direct visualization of color and luminescence readouts can improve the convenience of modern detection and has the potential to replace some traditional technologies in a simplified manner. Photochromic materials are a class of compounds that can reversibly light-switch between two different states or isomers with significantly different properties, and have been widely used in the fields of data storage and molecular photoswitches. Although there are reports that X-rays can be used to activate photochromic materials, they are limited to inorganic photochromic materials. Because the carbon chain skeleton of organic molecules has a small attenuation coefficient for X-rays, there are disadvantages such as weak absorption and poor response, which severely limits the integration of X-rays in organic photochromic materials. Therefore, it is of great scientific significance to develop a photochromic system that can actively respond to X-rays.
[0004] The present invention fills rare earth doped nano scintillators into the pixelated structure of the optical fiber panel and covers a layer of photochromic molecules to obtain an imaging plate. Under X-ray irradiation, the rare earth doped nano scintillators convert X-ray photons into visible photons, and after being transmitted to the photochromic molecules, the photochromic molecules are isomerized, thereby storing the X-ray information in the structure of the photochromic molecules. The pixelated structure thus formed can effectively reduce light crosstalk and achieve the effect of high-resolution imaging, and by utilizing the effective absorption of X-rays by rare earth doped nano scintillators, it can effectively solve the shortcomings of photochromic molecules such as weak response to X-ray absorption. During real-time imaging, the information can be recorded and converted into a digital image by a digital camera to complete high-resolution imaging; during visual imaging, the pixelated imaging plate presents color differences on a macro scale, and the information is recorded and converted into a digital image by a digital camera to complete information reading. In summary, the present invention has developed a method for preparing a pixelated X-ray imaging plate with isolated light crosstalk, which can achieve high-resolution imaging of fine structures and visual imaging of some objects, providing ideas for developing new X-ray imaging modes. Summary of the invention
[0005] The purpose of the present invention is to provide a pixelated X-ray imaging plate for isolating light crosstalk and its application. The present invention integrates the pixelated structure for preventing light crosstalk, the strong X-ray absorption ability of rare earth doped nano scintillators and the information storage ability of photochromic materials through an optical fiber panel to obtain a panel that can be used for X-ray imaging.
[0006] In order to achieve the above-mentioned invention object, the present invention adopts the following technical scheme: A pixelated X-ray imaging plate for isolating optical crosstalk is formed by filling rare earth doped nano scintillator NaYF4:Tb into an optical fiber panel by filtration, and covering the surface of the optical fiber panel with photochromic molecules.
[0007] The method for preparing the pixelated X-ray imaging plate for isolating optical crosstalk comprises the following steps: 1) Synthesis of rare earth doped nano scintillator NaYF4:Tb: Ethanol and oleic acid were stirred and mixed, and then sodium hydroxide solution was added. After stirring evenly, sodium fluoride solution, yttrium nitrate aqueous solution and terbium nitrate aqueous solution were added successively, and stirred separately to completely mix the above reactants. Then, the reaction was carried out at 200 °C for 12 h, washed with ethanol, and centrifuged to obtain rare earth doped nano scintillator NaYF4:Tb; 2) Preparation of pixelated isolated light crosstalk imaging plate: Ultrasonic dispersion of the rare earth doped nanoscintillator obtained in step 1) in ethanol to obtain a dispersion; then placing the optical fiber panel on a suction filtration bottle for suction filtration, and dripping the obtained dispersion on the optical fiber panel with a dropper, after the suction filtration is completed, placing the optical fiber panel to allow the ethanol to evaporate completely; then dripping the ethanol solution of the photochromic molecule on the evaporated surface of the optical fiber panel, and drying at room temperature to obtain the X-ray imaging plate.
[0008] Furthermore, the concentration of the sodium hydroxide solution in step 1) is 2.5 mol / L.
[0009] Furthermore, the concentration of the sodium fluoride solution in step 1) is 0.5 mol / L.
[0010] Furthermore, the concentrations of the yttrium nitrate aqueous solution and the terbium nitrate aqueous solution in step 1) are both 0.2 mol / L.
[0011] Furthermore, the volume ratio of ethanol, oleic acid, sodium hydroxide solution, sodium fluoride solution, yttrium nitrate aqueous solution and terbium nitrate aqueous solution used in step 1) is 2.5:2.5:1.5:2:0.96:0.24.
[0012] Furthermore, in step 1), the stirring time for ethanol and oleic acid is 10 min, and the stirring time for the remaining solutions after addition is 20 min.
[0013] Furthermore, the centrifugation speed in step 1) is 8000 rpm and the time is 5 min.
[0014] Furthermore, the nanoparticles of the rare earth doped nanoscintillator NaYF4:Tb obtained in step 1) are in a hexagonal phase and have a size of 150 nm±15 nm.
[0015] Furthermore, in step 2), the ratio of the rare earth doped nano scintillator to ethanol is 10 mg:3 mL.
[0016] Furthermore, in step 2), the amount of dispersion added to the optical fiber panel is 20-26 mL / cm 2 .
[0017] Furthermore, in step 2), the content of the photochromic molecule in the ethanol solution of the photochromic molecule is 3 mg / mL.
[0018] Furthermore, the photochromic molecule is a dithienylethylene photochromic compound, such as 1,2-bis(2,4-dimethyl-5-phenyl-3-thienyl)-3,3,4,4,5,5-hexafluoro-1-cyclopentene (DTE) and the like.
[0019] Furthermore, the amount of the ethanol solution of the photochromic molecules added to the optical fiber panel in step 2) is 0.1-0.15 mL / cm 2 .
[0020] One of the applications of the pixelated X-ray imaging plate with isolated optical crosstalk is for real-time X-ray imaging, which specifically involves placing the imaging target between the X-ray imaging plate and the X-rays for imaging, and recording the imaging pattern with a camera to achieve high-resolution imaging. The specific mechanism is that after the X-rays irradiate the scintillator to emit light, the pixelated structure causes the scintillation photons to propagate in the vertical direction to reduce the unwanted lateral photon leakage and guide the photons to be fully reflected in the specified space, thereby achieving high-resolution imaging.
[0021] The second application of the pixelated X-ray imaging plate with isolated light crosstalk is for visualization imaging, which is to irradiate the X-ray imaging plate with ultraviolet light, then place the imaging target between the imaging plate and the X-ray for imaging, and use a camera to record the imaging pattern to achieve visualization imaging of the object. Its specific mechanism is: the photochromic molecules will undergo isomerization after absorbing ultraviolet photons, and the emission peak positions of molecules with different structures in the visible light region are different, thus showing different colors; the X-ray fluorescence emission range of the prepared rare earth doped nanoscintillator coincides with the visible light absorption peak of the photochromic molecules, but does not coincide with the ultraviolet absorption peak of the photochromic molecules. Therefore, when the prepared rare earth doped nanoscintillator absorbs high-energy X-rays, the emitted visible light photons can be absorbed by the photochromic molecules, thereby inducing their color to change. Due to the different absorption capacity of objects of different densities and thicknesses to X-rays, the X-ray energy received by the imaging film is significantly different, thereby leaving pattern information.
[0022] The significant advantages of the present invention are: (1) The pixelated isolated light crosstalk X-ray imaging plate prepared by the present invention can perform high-resolution imaging of precise objects.
[0023] (2) The photochromic visualization imaging plate prepared by the present invention can completely separate the two steps of memory and reading, so there is no need for a real-time signal transmission device for image recording.
[0024] (3) The present invention introduces photochromic molecules with structural reversibility, so that the obtained imaging plate can be reused. BRIEF DESCRIPTION OF THE DRAWINGS
[0025] Figure 1 This is a transmission electron microscope image of the rare earth-doped nano-scintillator NaYF4:Tb prepared in Example 1.
[0026] Figure 2This is the X-ray excited luminescence spectrum of the rare earth doped nano scintillator NaYF4:Tb prepared in Example 1.
[0027] Figure 3 This is an optical microscope image of the pixelated isolated light crosstalk X-ray imaging plate prepared in Example 2.
[0028] Figure 4 These are the absorption spectra of DTE molecules with different configurations in Example 2 and the X-ray emission spectra of NaYF4:Tb nanoscintillator.
[0029] Figure 5 Schematic diagram of X-ray imaging using an X-ray imaging plate in Example 3 (A) and the obtained real-time imaging diagram (B).
[0030] Figure 6 This is the photochromic imaging image obtained by using an X-ray imaging plate in Example 3. DETAILED DESCRIPTION
[0031] In order to make the contents of the present invention easier to understand, the technical solution of the present invention is further described below in conjunction with specific implementation methods, but the present invention is not limited thereto.
[0032] Example 1 Synthesis of rare earth doped nano-scintillator NaYF4:Tb 2.5 mL of ethanol and 2.5 mL of oleic acid were added to the inner lining of the hydrothermal reactor and stirred for 10 min, then 1.5 mL of 2.5 mol / L sodium hydroxide solution was added and stirred for 20 min, then 2 mL of 0.5 mol / L sodium fluoride solution was added and stirred for 20 min, then 960 μL of 0.2 mol / L yttrium nitrate aqueous solution and 240 μL of 0.2 mol / L terbium nitrate aqueous solution were added and stirred for 20 min respectively, and finally the reactor was sealed and placed in an oven at 200 °C for 12 h. After the reaction, the product was washed with ethanol several times by centrifugation at 8000 rpm for 5 min to obtain the rare earth doped nano-scintillator NaYF4:20%Tb.
[0033] The prepared nanoscale NaYF4:Tb white powder was analyzed using a transmission electron microscope. Figure 1 The transmission electron microscope image is obtained. Figure 1 It can be seen that the obtained nanoparticles are hexagonal, well dispersed and uniform in size, which is 150nm±15nm.
[0034] The prepared nanoscale NaYF4:Tb white powder was analyzed using X-ray induced luminescence spectroscopy. Figure 2 The obtained X-ray excitation luminescence spectrum is shown in Figure 2. Figure 2It can be seen that the fluorescence emission pattern of NaYF4:Tb material corresponds to Tb 3+ Four characteristic emission peaks 5 D4→ 7 F6, 5 D4→ 7 F5, 5 D4→ 7 F4 and 5 D4→ 7 F3.
[0035] Example 2 Preparation of pixelated X-ray imaging plate for isolating optical crosstalk 60 mg of the NaYF4:Tb nanoscintillator prepared in Example 1 was dispersed in 180 mL of ethanol, and ultrasonicated in an ultrasonic machine until the nanoscintillator was evenly dispersed. Then, a through-hole optical fiber panel with a diameter of 30 mm, a thickness of 400 μm, and an aperture of 10 μm was placed on a suction filtration bottle for suction filtration, and 180 mL of NaYF4:Tb dispersion was dripped onto the optical fiber panel with a dropper. After the filtration was completed, the optical fiber panel was placed for a period of time to allow the ethanol to evaporate completely, and then 15 mg of the photochromic molecule DTE was added to 5 mL of ethanol. After ultrasonication, 1 mL was taken and dripped onto the surface of the evaporated optical fiber panel and dried at room temperature. The prepared pixelated imaging plate is white, and this color mainly comes from the color of the NaYF4:Tb nanoscintillator.
[0036] Figure 3 This is an image of the resulting pixelated, isolated optical crosstalk X-ray imaging plate under an optical microscope. Figure 3 It can be seen that the pixelated structure makes the scintillation photons propagate in the vertical direction to reduce the unwanted lateral photon leakage.
[0037] Figure 4 The absorption spectra of DTE molecules with different configurations and the X-ray emission spectra of NaYF4:Tb nanoscintillator are shown in Figure 2. Figure 4 As shown in the figure, the X-ray fluorescence emission range of NaYF4:Tb nanoscintillator is 450-650 nm. This broad spectrum emission can overlap well with the visible light absorption peak of the closed-ring DTE molecule, but does not overlap with the ultraviolet absorption peak of the DTE molecule. Therefore, when the NaYF4:Tb nanoscintillator absorbs high-energy X-rays, the emitted visible light photons can be absorbed by the photochromic molecules, thereby inducing their color to change.
[0038] Example 3 Construction of pixelated isolated optical crosstalk X-ray imaging technology 1. If Figure 5, the imaging object is placed between the X-ray source and the X-ray imaging plate prepared in Example 2. Under X-ray irradiation (50 kV, 200 μA), the scintillator material in the imaging plate continuously emits visible light. Since different parts of the imaging object have different X-ray blocking abilities, the light emitted from different positions of the imaging plate is different, so that the pattern can be recorded in real time with a digital camera.
[0039] 2. Place the X-ray imaging plate prepared in Example 2 in a box-type UV lamp and irradiate it with a 365 nm UV lamp for 90 s, so that the open-ring DTE molecules absorb ultraviolet light and isomerize into closed-ring DTE molecules. At this time, the imaging plate appears purple. Then, place the imaging object between the X-ray source and the imaging plate. Under continuous X-ray irradiation (50 kV, 200 μA, 5 min), the scintillator material in the imaging plate continuously emits visible light photons, causing the surface closed-loop DTE molecules to re-isomerize and transform into open-loop DTE molecules. Due to the different materials and thicknesses of various parts of the imaging object, there are differences in the X-ray energy received by the imaging plate, thereby leaving pattern information. After the X-ray irradiation stops, the pattern on the imaging plate is recorded and stored as an image by a digital camera. The imaging effect is as follows. Figure 6 shown.
[0040] The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made according to the scope of the patent application of the present invention should fall within the scope of the present invention.
Claims
1. An X-ray imaging plate with pixelated isolation of optical crosstalk, characterized in that: The X-ray imaging plate is formed by filling rare earth doped nano scintillator NaYF4:Tb into an optical fiber panel by filtration, and covering the surface of the optical fiber panel with photochromic molecules.
2. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 1, characterized in that: The preparation method comprises the following steps: 1) Synthesis of rare earth doped nano scintillator NaYF4:Tb: Ethanol and oleic acid were stirred and mixed, and then sodium hydroxide solution was added. After stirring evenly, sodium fluoride solution, yttrium nitrate aqueous solution and terbium nitrate aqueous solution were added successively under continuous stirring to completely mix the above reactants. Then, the mixture was reacted at 200 °C for 12 h, washed with ethanol, and centrifuged to obtain rare earth doped nano scintillator NaYF4:Tb. 2) Preparation of pixelated isolated light crosstalk imaging plate: Ultrasonic dispersion of the rare earth doped nanoscintillator obtained in step 1) in ethanol to obtain a dispersion; then filter the optical fiber panel, and drip the obtained dispersion on the optical fiber panel with a dropper, and after the filtration is completed, place the optical fiber panel to allow the ethanol to evaporate completely; then drip the ethanol solution of the photochromic molecule on the evaporated surface of the optical fiber panel, and dry it at room temperature to obtain the X-ray imaging plate.
3. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: The volume ratio of ethanol, oleic acid, sodium hydroxide solution, sodium fluoride solution, yttrium nitrate aqueous solution and terbium nitrate aqueous solution used in step 1) is 2.5:2.5:1.5:2:0.96:0.24; wherein the concentration of the sodium hydroxide solution is 2.5 mol / L; the concentration of the sodium fluoride solution is 0.5 mol / L; the concentrations of the yttrium nitrate aqueous solution and the terbium nitrate aqueous solution are both 0.2 mol / L.
4. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: In step 1), the stirring time of ethanol and oleic acid is 10 min, and the stirring time of the remaining solutions after addition is 20 min.
5. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: The centrifugation speed in step 1) is 8000 rpm and the time is 5 min.
6. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: In step 2), the ratio of rare earth doped nano scintillator to ethanol is 10 mg:3 mL.
7. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: In step 2), the amount of dispersion added to the optical fiber panel is 20~26 mL / cm 2 .
8. The pixelated X-ray imaging plate for isolating optical crosstalk according to claim 2, characterized in that: Step 2) The content of the photochromic molecule in the ethanol solution of the photochromic molecule is 3 mg / mL, and the amount of the photochromic molecule added to the optical fiber panel is 0.1-0.15 mL / cm 2 ; The photochromic molecule is a dithienylethylene photochromic compound.
9. Application of the pixelated X-ray imaging plate with isolated optical crosstalk as claimed in claim 1 in real-time X-ray imaging.
10. An application of the pixelated X-ray imaging plate with isolated optical crosstalk as claimed in claim 1 in visual imaging, characterized in that: The X-ray imaging plate is irradiated with ultraviolet light, and then the imaging target is placed between the imaging plate and the X-rays for imaging and recording.