Compound oil with functions of regulating blood fat and relaxing bowel as well as preparation method and application of compound oil

Abstract

The invention discloses compound oil with functions of regulating blood fat and relaxing bowel as well as a preparation method and application of the compound oil. The invention aims at solving the health problems of human body hyperlipidemia, constipation and the like. The preparation method of the compound oil with the functions of regulating blood fat and relaxing bowel comprises the following steps: 1, respectively filtering the krill oil and the cannabis oil at low temperature to remove impurities, and mixing the filtered krill oil and cannabis oil according to the mass ratio of (10-90): (90-10); dissolving and uniformly dispersing astaxanthin by using an organic solvent to obtain an astaxanthin solution; 2, uniformly stirring and mixing the filtered krill oil and cannabis oil with the astaxanthin solution at the temperature of 40-50 DEG C; the compound oil disclosed by the invention can regulate blood fat and relax bowel, wherein the blood fat regulation is embodied by reducing the levels of cholesterol and triglyceride and increasing the level of high-density lipoprotein cholesterol; intestine moistening and bowel relaxing are embodied in improving intestinal functions, enhancing intestinal peristalsis, relieving constipation and maintaining intestinal microecological balance.

Description

Technical Field

[0001] The invention belongs to the technical field of health food, and specifically relates to an astaxanthin krill oil hemp oil composite oil and a preparation method thereof. The composite oil has the functions of regulating blood lipids and moisturizing the intestines and facilitating bowel movements. Background Art

[0002] The change of modern lifestyle has made health problems such as high blood lipids and constipation more common, which has had an adverse impact on people's quality of life. Therefore, it is of great significance to develop health foods with the functions of regulating blood lipids and moisturizing the intestines.

[0003] Antarctic krill oil is rich in a variety of nutrients, such as unsaturated fatty acids (especially EPA and DHA), phospholipids, astaxanthin, etc. Among them, unsaturated fatty acids help lower blood lipid levels and reduce the risk of cardiovascular diseases; phospholipids have good emulsifying properties and can promote lipid metabolism; astaxanthin, as a strong antioxidant, can reduce the damage of oxidative stress to the body, assist in regulating the inflammatory response in the process of blood lipid metabolism, and enhance the overall effect of regulating blood lipids.

[0004] Hemp oil is rich in unsaturated fatty acids (such as linoleic acid and linolenic acid), vitamin E and a variety of active ingredients. Its unsaturated fatty acids can improve lipid metabolism and reduce the cholesterol and triglyceride levels in the blood; its rich nutrients can nourish the intestinal mucosa, enhance intestinal motility, and play a role in moisturizing the intestines and facilitating bowel movements. It also works synergistically with the nutrients in krill oil to further improve the effect of improving blood lipids and intestinal function.

[0005] Although there are various products for regulating blood lipids or moistening the intestines and relieving constipation on the market, there is no product that scientifically combines Antarctic krill oil, hemp oil and astaxanthin. The present invention aims to fill this gap and provide a new type of health food that is rich in nutrition and has significant effects. Summary of the invention

[0006] The purpose of the present invention is to improve health problems such as hyperlipidemia and constipation in the human body, and to provide an astaxanthin krill oil hemp oil composite oil with the functions of regulating blood lipids and moistening the intestines and relieving constipation, as well as a preparation method and application thereof.

[0007] The composite oil with the function of regulating blood lipid and moistening intestines and relieving constipation comprises astaxanthin, krill oil and hemp oil, wherein the mass ratio of krill oil to hemp oil is (10-90):(90-10), and the astaxanthin content in the composite oil is ≥500ppm.

[0008] The main raw materials of the composite oil with the function of regulating blood lipids and moistening the intestines and relieving constipation of the present invention are (Antarctic) krill oil and hemp oil, the ratio of the two is 1:1, and the astaxanthin content is ≥500ppm. Antarctic krill oil is rich in unsaturated fatty acids (EPA and DHA), phospholipids and astaxanthin. Unsaturated fatty acids reduce blood lipids, phospholipids promote lipid metabolism, and astaxanthin is antioxidant and assists in regulating blood lipid metabolism and inflammatory response. The unsaturated fatty acids in hemp oil can improve lipid metabolism, and the nutrients nourish the intestinal mucosa, promote peristalsis, and synergize with krill oil. Optimizing the content of astaxanthin can inhibit lipid peroxidation, reduce intestinal inflammation, optimize the intestinal microenvironment, and coordinate krill oil and hemp oil to improve efficacy.

[0009] The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation of the present invention is achieved by the following steps:

[0010] Step 1: Raw material pretreatment:

[0011] The krill oil and hemp oil are filtered at low temperature to remove impurities, and the filtered krill oil and hemp oil are mixed in a mass ratio of (10-90):(90-10); astaxanthin is dissolved and evenly dispersed in an organic solvent to obtain an astaxanthin solution;

[0012] Step 2: Mixing:

[0013] The filtered krill oil, hemp oil and astaxanthin solution are stirred and mixed evenly at a temperature of 40-50° C. to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines and facilitating bowel movements.

[0014] The application of the composite oil with the functions of regulating blood lipids and moistening the intestines and relieving constipation of the present invention is to use the composite oil with the functions of regulating blood lipids and moistening the intestines and relieving constipation as a functional food or a health food.

[0015] The composite oil described in the present invention can regulate blood lipids and moisten the intestines and promote bowel movements, wherein regulating blood lipids is manifested in lowering cholesterol and triglyceride levels and increasing high-density lipoprotein cholesterol (HDL-C) levels; moisturizing the intestines and promoting bowel movements is manifested in improving intestinal function, enhancing intestinal peristalsis, relieving constipation, and maintaining intestinal microecological balance.

[0016] The composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation, as well as the preparation method and application thereof, of the present invention have the following beneficial effects:

[0017] 1. Regulate blood lipids: Multiple ingredients synergistically lower cholesterol and triglycerides, increase high-density lipoprotein cholesterol (HDL-C) levels, and prevent cardiovascular diseases.

[0018] 2. Lubricate the intestines and promote bowel movements: improve intestinal function, enhance peristalsis, relieve constipation, and maintain the balance of intestinal microecology.

[0019] 3. Antioxidant: Antioxidant ingredients such as astaxanthin can remove free radicals, reduce oxidative stress damage, and protect cell tissues.

[0020] 4. Easy to eat: The compound oil dosage form can be taken directly or added to food. It is convenient and flexible, and suitable for daily health care for people with dyslipidemia and constipation. DETAILED DESCRIPTION

[0021] Specific implementation method 1: In this implementation method, the composite oil with the function of regulating blood lipids and moisturizing the intestines and promoting bowel movements includes astaxanthin, krill oil and hemp oil, wherein the mass ratio of krill oil to hemp oil is (10-90):(90-10), and the astaxanthin content in the composite oil (system) is ≥500ppm.

[0022] In addition to its antioxidant effect, astaxanthin in this embodiment can also inhibit lipid peroxidation, reduce the oxidative modification of low-density lipoprotein cholesterol, and reduce the risk of atherosclerosis in regulating blood lipids. In terms of intestinal health, it can reduce intestinal inflammation, improve the intestinal microenvironment, and help moisturize the intestines and promote bowel movements. Together with krill oil and hemp oil, it can build a comprehensive protection system for blood lipids and intestinal health.

[0023] Specific implementation method 2: This implementation method is different from specific implementation method 1 in that the krill oil is Antarctic krill oil.

[0024] Specific implementation method three: This implementation method is different from specific implementation methods one or two in that the astaxanthin content in the composite oil is ≥500ppm, and the astaxanthin content is ≤1000ppm.

[0025] Specific embodiment 4: This embodiment is different from any one of specific embodiments 1 to 3 in that the mass ratio of krill oil to hemp oil is (30-70):(70-30).

[0026] In this embodiment, the mass ratio of krill oil and hemp oil is optimized to 50:50.

[0027] Specific embodiment 5: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0028] Step 1: Raw material pretreatment:

[0029] The krill oil and hemp oil are filtered at low temperature to remove impurities, and the filtered krill oil and hemp oil are mixed in a mass ratio of (10-90):(90-10); astaxanthin is dissolved and evenly dispersed in an organic solvent to obtain an astaxanthin solution;

[0030] Step 2: Mixing:

[0031] The filtered krill oil, hemp oil and astaxanthin solution are stirred and mixed evenly at a temperature of 40-50° C. to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines and facilitating bowel movements.

[0032] Specific embodiment 6: This embodiment is different from specific embodiment 5 in that the temperature of low temperature filtration in step 1 is 4-20° C., and a filter membrane is used for filtration, and the pore size of the filter membrane is 0.1-0.3 μm.

[0033] Specific embodiment 7: This embodiment is different from specific embodiment 5 or 6 in that the organic solvent described in step 1 is anhydrous ethanol, and the amount of anhydrous ethanol used is 10 to 20 times the mass of astaxanthin.

[0034] Specific embodiment eight: This embodiment differs from any one of specific embodiments five to seven in that in step two, stirring is performed at a temperature of 40 to 50° C. and a speed of 400 to 600 r / min for 20 to 40 min.

[0035] Specific embodiment nine: This embodiment differs from any one of specific embodiments five to eight in that the mixing and blending process in step two is replaced by: dissolving the filtered krill oil and hemp oil in anhydrous ethanol to obtain a krill oil and hemp oil solution, mixing the krill oil and hemp oil solution with the astaxanthin solution, and then removing the anhydrous ethanol by reduced pressure distillation to obtain a composite oil having the function of regulating blood lipids and moisturizing the intestines.

[0036] Embodiment 1: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0037] Step 1: Raw material pretreatment:

[0038] Antarctic krill oil and hemp oil were filtered through a 0.2 μm filter membrane at 4° C. to remove impurities, and 90 g of the filtered krill oil and 10 g of hemp oil were mixed; astaxanthin was dissolved and dispersed evenly with anhydrous ethanol to obtain an astaxanthin solution, and ethanol was removed by vacuum distillation;

[0039] Step 2: Mixing:

[0040] The filtered krill oil, hemp oil and astaxanthin solution were stirred and mixed at a temperature of 40° C. and a speed of 500 r / min for 30 minutes to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines.

[0041] Embodiment 2: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0042] Step 1: Raw material pretreatment:

[0043] Antarctic krill oil and hemp oil were filtered through a 0.2 μm filter membrane at 4° C. to remove impurities, and 70 g of the filtered krill oil and 30 g of hemp oil were mixed; astaxanthin was dissolved and dispersed evenly with anhydrous ethanol to obtain an astaxanthin solution, and ethanol was removed by vacuum distillation;

[0044] Step 2: Mixing:

[0045] The filtered krill oil, hemp oil and astaxanthin solution were stirred and mixed at a temperature of 42° C. and a speed of 550 r / min for 35 minutes to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines.

[0046] Embodiment 3: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0047] Step 1: Raw material pretreatment:

[0048] Antarctic krill oil and hemp oil were filtered through a 0.2 μm filter membrane at 4° C. to remove impurities, and 50 g of the filtered krill oil and 50 g of hemp oil were mixed; astaxanthin was dissolved and dispersed evenly with anhydrous ethanol to obtain an astaxanthin solution, and ethanol was removed by vacuum distillation;

[0049] Step 2: Mixing:

[0050] The filtered krill oil, hemp oil and astaxanthin solution were stirred and mixed at a temperature of 45° C. and a speed of 500 r / min for 40 minutes to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines.

[0051] The content of astaxanthin in the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is 557 ppm.

[0052] Embodiment 4: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0053] Step 1: Raw material pretreatment:

[0054] Antarctic krill oil and hemp oil were filtered through a 0.2 μm filter membrane at 4° C. to remove impurities, and 30 g of the filtered krill oil and 70 g of hemp oil were mixed; astaxanthin was dissolved and dispersed evenly with anhydrous ethanol to obtain an astaxanthin solution, and ethanol was removed by vacuum distillation;

[0055] Step 2: Mixing:

[0056] The filtered krill oil, hemp oil and astaxanthin solution were stirred and mixed at a temperature of 48° C. and a speed of 450 r / min for 30 minutes to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines.

[0057] Embodiment 5: The preparation method of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation in this embodiment is implemented according to the following steps:

[0058] Step 1: Raw material pretreatment:

[0059] Antarctic krill oil and hemp oil were filtered through a 0.2 μm filter membrane at 4° C. to remove impurities, and 10 g of the filtered krill oil and 90 g of hemp oil were mixed; astaxanthin was dissolved and dispersed evenly with anhydrous ethanol to obtain an astaxanthin solution, and ethanol was removed by vacuum distillation;

[0060] Step 2: Mixing:

[0061] The filtered krill oil, hemp oil and astaxanthin solution were stirred and mixed at a temperature of 50° C. and a speed of 400 r / min for 20 minutes to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines.

[0062] Experimental data and analysis

[0063] 1. Blood lipid regulation experiment

[0064] Experimental grouping and treatment: 40 mice were divided into four groups, blank control group, A high-fat model group, B astaxanthin plus krill oil group, C astaxanthin plus krill oil plus hemp oil group (i.e., the composite oil prepared in Example 3), and the indicators were measured after 8 weeks of corresponding treatment.

[0065] Test indicators and results:

[0066] TG (triglyceride): The level was higher in Group A, lower in Group B, and most significantly lower in Group C.

[0067] TC (cholesterol): The content in Group A was higher, and the reduction in Group B was smaller than that in Group C, and Group C showed the best reduction effect.

[0068] Arteriosclerosis index (AI): AI = (TC-HDL-C) / HDL-C. The higher the HDL-C and the lower the TC, the lower the AI ​​and the lower the risk of atherosclerosis. The AI ​​value of group A was higher, group B decreased, and group C decreased the most, indicating that group C had the strongest preventive effect on atherosclerosis.

[0069] 2. Bowel-moistening and laxative experiment

[0070] Experimental grouping and treatment: 40 mice were divided into four groups, namely A astaxanthin plus krill oil group, B astaxanthin plus krill oil plus hemp oil group, rhubarb water extract group, and normal control group.

[0071] Test indicators and results: The group of the present invention had increased bowel movement frequency, good properties, and excellent intestinal function indicators, reflecting the product's excellent intestinal moisturizing and laxative effects.

[0072] Animal testing

[0073] Purpose

[0074] Evaluate the effects of astaxanthin, krill oil and hemp oil compound oil on animal blood lipids and intestinal function, verify its blood lipid regulating and intestinal moisturizing and laxative effects, and provide a scientific basis for the application of the product.

[0075] Experimental Materials

[0076] 1. Experimental animals: Kunming mice (weight 20-22 g, half male and half female, SPF grade) were used.

[0077] 2. Test drugs: In the experiment, they were divided into astaxanthin plus krill oil group and astaxanthin plus krill oil plus hemp oil group (i.e., the composite oil prepared in Example 3).

[0078] 3. Control drugs

[0079] Blank control: normal saline.

[0080] Positive control drug (intestinal laxative experiment): Rhubarb (before the experiment, add 10 times the amount of water to its powder and boil it for 30 minutes, twice in total, combine the decoction, concentrate it to a solution containing 1.0g of crude drug per 1mL, and store it in the refrigerator for later use). Rhubarb water extract has the effects of purging and attacking accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredge menstruation, etc. It is often used in the field of traditional Chinese medicine to treat symptoms such as excess heat stagnation and constipation.

[0081] Model group (lipid-lowering experiment): hyperlipidemia model mice were selected and fed with normal saline as a control during the experiment.

[0082] Experimental groups and dosage

[0083] 1. Experimental grouping of mice (blood lipid regulation experiment): The mice were divided into 4 groups, with 10 mice in each group, namely blank control group, A high-fat model group, B astaxanthin plus krill oil group, C astaxanthin plus krill oil plus hemp oil group.

[0084] 2. Dosage (blood lipid regulation experiment): The blank control group was fed with normal saline, the A high-fat model group was fed with normal saline, the B group was fed with astaxanthin plus krill oil, and the C group was fed with astaxanthin plus krill oil plus hemp oil. According to the experimental design, a dose of 0.01 mL / g / d was given.

[0085] 3. Experimental grouping of mice (intestinal lubrication and laxative experiment): 40 mice fasted for 24 hours were divided into 4 groups, with 10 mice in each group, namely A astaxanthin plus krill oil group (10mL / kg), B astaxanthin plus krill oil plus hemp oil group (10mL / kg), rhubarb water extract group (10mL / kg), and normal control group (10mL / kg of normal saline).

[0086] 4. Dosage (laxative experiment): The dosage of group A astaxanthin plus krill oil was 10 mL / kg, the dosage of group B astaxanthin plus krill oil plus hemp oil was 10 mL / kg, the dosage of rhubarb water extract group was 10 mL / kg, and the dosage of normal saline in the normal control group was 10 mL / kg.

[0087] Experimental methods and index detection

[0088] 1. Blood lipid index detection (blood lipid regulation experiment)

[0089] After the experiment, the blood of the mice was collected and the serum was separated by centrifugation. The concentrations of triglyceride (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured using a biochemical analyzer. At the same time, the arteriosclerosis index (AI) was calculated to evaluate the changes in blood lipid levels.

[0090] 2. Observation of defecation time and amount (intestinal lubrication and laxative experiment)

[0091] After fasting for 24 hours, the mice were divided into groups and given drugs by gavage, and then placed in a bell jar covered with filter paper for observation. The defecation time, feces morphology and quantity of the mice were recorded. The observation lasted for 6 hours, and the average value of each group was taken for analysis and comparison.

[0092] 3. Small intestinal motility test (intestinal lubrication and laxative test)

[0093] After fasting for 24 hours, the mice were divided into groups and given drugs, and ink solution (0.1 mL / 10 g) was injected through a stomach tube. After 30 minutes, the mice were killed and dissected, and the intestinal segment between the pylorus and the ileocecal part was removed, and the total length of the intestinal segment (M) and the distance of ink advancement (N) were measured. The percentage of ink advancement (=N / M×100%) was calculated by the formula to evaluate the motor function of the small intestine.

[0094] 4. Small Intestine Volume Measurement (Intestinal Lubrication and Laxative Test)

[0095] After fasting for 24 hours, the mice were divided into groups and killed 2 hours after administration. The abdominal cavity was opened to remove the intestinal tube, and the lower end of the pylorus and the end of the rectum were ligated with silk thread. The mesentery and fat were carefully removed to avoid damaging blood vessels. The whole intestine was weighed and the relative weight coefficient of the small intestine was calculated (= small intestine weight / body weight).

[0096] 5. Colon motility test (intestinal laxative test)

[0097] After fasting for 24 hours, the mice were divided into groups and given drugs. Under mild anesthesia, the ileocecal region was located and normal saline (2 mL / kg) containing ink was injected into the ileocecal region of the mice using a syringe. The ileocecal segment was double-ligated and the ileum was cut, and the intestine was reset and the abdominal incision was sutured after timing. The mice were killed 2 hours later, the colon was cut and its total length and ink advancement distance were measured, and the advancement percentage was calculated and statistically analyzed.

[0098] Experimental Results

[0099] 1. Results of blood lipid regulation experiment

[0100] TG (triglyceride): Group A had a higher TG level, Group B had a lower TG level than Group A, and Group C had the largest decrease, showing the best TG lowering effect.

[0101] TC (cholesterol): The TC content in Group A was higher, that in Group B was lower than that in Group A, and that in Group C was the most significantly reduced, indicating that Group C had the best effect in lowering cholesterol.

[0102]

[0103] Note: * P<0.05, ** P<0.01, compared with the model group.

[0104] Arteriosclerosis index (AI): The AI ​​value of group A was higher, that of group B was lower, and that of group C was the largest, indicating that group C had the strongest effect in preventing atherosclerosis.

[0105]

[0106] Note: * P<0.05, ** P<0.01, compared with the model group.

[0107] 2. Results of the laxative test

[0108] Defecation time and number of defecation: Compared with the normal control group, mice in each dose group of the compound oil excreted more feces, the surface of the feces was shiny, soft and formed; the A astaxanthin plus krill oil group began to excrete black feces faster, and the number of black feces excreted within 6 hours was significantly more than that of the blank group, and the B astaxanthin plus krill oil plus hemp oil group had the most significant effect.

[0109]

[0110] Note: * P<0.05, ** P<0.01, compared with the normal control group.

[0111] Small intestinal motility function: Group A astaxanthin plus krill oil can significantly promote the small intestinal motility of mice, enhance propulsive peristalsis, and increase the ink propulsion rate. Group B astaxanthin plus krill oil plus hemp oil has better effect than Group A astaxanthin plus krill oil.

[0112]

[0113] Note: * P<0.05, ** P<0.01, compared with the normal control group.

[0114] Small intestine volume: Group A astaxanthin plus krill oil can increase the volume of the small intestine of mice to a certain extent, thereby improving the small intestine coefficient. Group B astaxanthin plus krill oil plus hemp oil showed a more obvious increase in the small intestine coefficient.

[0115]

[0116] Note: * P<0.05, ** P<0.01, compared with the normal control group.

[0117] Large intestine motility function: Group A astaxanthin plus krill oil can significantly promote the motility of the mouse large intestine, enhance propulsive peristalsis, and increase the ink propulsion rate. Group B astaxanthin plus krill oil plus hemp oil has a more significant effect.

[0118]

[0119]

[0120] Note: * P<0.05, ** P<0.01, compared with the normal control group.

[0121] Experimental conclusion

[0122] The above animal experiments have proven that astaxanthin krill oil hemp oil compound oil has significant effects on regulating blood lipids and moistening the intestines. In terms of regulating blood lipids, its mechanism of action is related to the synergistic reduction of blood lipid-related indicators by multiple components; in terms of moistening the intestines, it is closely related to stimulating intestinal peristalsis and increasing intestinal volume. This provides a strong experimental basis for the application of this product in improving blood lipids and intestinal function, and further reflects its potential application value in the field of health food.

Claims

1. A composite oil having the function of regulating blood lipids and moistening the intestines and relieving constipation, characterized in that The composite oil comprises astaxanthin, krill oil and hemp oil, wherein the mass ratio of the krill oil to the hemp oil is (10-90):(90-10), and the astaxanthin content in the composite oil is ≥500ppm.

2. The composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 1, characterized in that The krill oil is Antarctic krill oil.

3. The composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 1, characterized in that The astaxanthin content in the composite oil is ≥500ppm, and the astaxanthin content is ≤1000ppm.

4. The composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 3, characterized in that The mass ratio of krill oil to hemp oil is (30-70):(70-30).

5. The method for preparing the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation as claimed in claim 1, characterized in that The preparation method is achieved by following the steps: Step 1: Raw material pretreatment: The krill oil and hemp oil are filtered at low temperature to remove impurities, and the filtered krill oil and hemp oil are mixed in a mass ratio of (10-90):(90-10); astaxanthin is dissolved and evenly dispersed in an organic solvent to obtain an astaxanthin solution; Step 2: Mixing: The filtered krill oil, hemp oil and astaxanthin solution are stirred and mixed evenly at a temperature of 40-50° C. to obtain a composite oil with the functions of regulating blood lipids and moisturizing the intestines and facilitating bowel movements.

6. The method for preparing the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 5, characterized in that In step 1, the temperature of low-temperature filtration is 4-20° C., and filtration is performed using a filter membrane with a pore size of 0.1-0.3 μm.

7. The method for preparing the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 5, characterized in that The organic solvent described in step 1 is anhydrous ethanol, and the amount of anhydrous ethanol used is 10 to 20 times the mass of astaxanthin.

8. The method for preparing the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 5, characterized in that Step 2: Stirring at a temperature of 40 to 50° C. and a speed of 400 to 600 r / min for 20 to 40 minutes.

9. The method for preparing the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation according to claim 5, characterized in that The mixing and blending process of step 2 is replaced by: dissolving the filtered krill oil and hemp oil in anhydrous ethanol to obtain a krill oil and hemp oil solution, mixing the krill oil and hemp oil solution with the astaxanthin solution, and then removing the anhydrous ethanol through reduced pressure distillation to obtain a composite oil with the function of regulating blood lipids and moisturizing the intestines.

10. The use of the composite oil having the functions of regulating blood lipids and moistening the intestines and relieving constipation as claimed in claim 1, characterized in that The composite oil with the functions of regulating blood lipids and moistening the intestines and relieving constipation is used as a functional food or a health food.

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