Traditional Chinese medicine composition for treating myocardial hypertrabeclization

Abstract

The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 5 to 10 parts of uncaria rhynchophylla, 8 to 12 parts of glabrous sarcandra herb, 12 to 20 parts of radix ranunculi ternati, 1 to 6 parts of dragon's blood, 3 to 8 parts of frankincense, 10 to 15 parts of trichosanthes kirilowii maxim root, 3 to 8 parts of radix bupleuri, 5 to 10 parts of wine-treated rhubarb, 5 to 10 parts of inula flower, 3 to 8 parts of polygala tenuifolia and 5 to 10 parts of tangerine pith. The traditional Chinese medicine composition has the characteristics of sufficient medicinal material source, low cost and higher safety, various medicines are mutually cooperated, both symptoms and root causes are treated, deficiency and excess are regulated, and the whole formula is based on the principle of monarch, minister, assistant and guide, and is rigorous and reasonable in compatibility and distinct in gradation. The core purpose of the traditional Chinese medicine is to reduce phlegm, resolve masses, promote qi circulation, relieve arthralgia, harmonize heart and kidney, enable qi and blood to flow smoothly and blood stasis to automatically disperse, jointly play the effects of promoting blood circulation, removing blood stasis, dredging channels and calming heart, and closely conform to the pathological mechanism of myocardial trabecula, so as to realize the cause-to-cause treatment.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicine compositions, and in particular is a Chinese medicine composition for treating excessive myocardial trabeculation. Background Art

[0002] Excessive myocardial trabeculation is a cardiomyopathy with abnormal cardiac structure. There are abnormally increased trabeculae on the inner wall of the heart. These trabeculae are usually deep and complex in structure, resulting in a spongy structure of the ventricular wall. Its clinical manifestations are non-specific and can range from no obvious symptoms to progressive heart failure symptoms such as chest tightness, fatigue, palpitations, decreased mobility, arrhythmias, embolism, and even sudden death. Some patients usually have systolic or relaxation dysfunction caused by left ventricular hypertrophy, and the condition is complicated.

[0003] At present, modern medicine mainly treats excessive myocardial trabeculation with symptomatic treatments such as improving fluid retention, inhibiting ventricular remodeling, anticoagulation, and antiarrhythmic treatment, but is relatively lacking in causal treatment. Studies have suggested that traditional Chinese medicine may have certain advantages in improving clinical symptoms of patients with excessive myocardial trabeculation, delaying the progression of heart failure, improving quality of life, and prolonging life expectancy. Summary of the invention

[0004] 1. Technical issues to be resolved In order to solve the problems existing in the prior art, a Chinese medicine composition for treating excessive myocardial trabeculation is proposed. The Chinese medicine composition has the characteristics of sufficient source of medicinal materials, low cost and high safety. It is used to give full play to the role of traditional Chinese medicine in excessive myocardial trabeculation and make up for the shortcomings of the prior art.

[0005] (II) Technical solution The technical solution adopted by the present invention is as follows: A traditional Chinese medicine composition for treating excessive myocardial trabeculation is prepared from the following traditional Chinese medicines in parts by weight: 5-10 parts of Uncaria rhynchophylla, 8-12 parts of Sarcandra chinensis, 12-20 parts of Ranunculaceae, 1-6 parts of Sanguisorba officinalis, 3-8 parts of frankincense, 10-15 parts of Trichosanthes root, 3-8 parts of Bupleurum chinense, 5-10 parts of Rheum officinale, 5-10 parts of Inula japonica, 3-8 parts of Polygala tenuifolia, and 5-10 parts of Citrus aurantium.

[0006] As a preferred embodiment, the Chinese medicine composition for treating excessive myocardial trabeculation of the present invention is made of the following Chinese medicinal materials in parts by weight: 10 parts of Uncaria rhynchophylla, 12 parts of Sarcandra scabra, 20 parts of Herba Lycopodii, 6 parts of Sanguisorba officinalis, 8 parts of Olibanum, 15 parts of Root of Trichosanthes, 8 parts of Radix Bupleuri, 10 parts of Rheum officinale, 10 parts of Inula japonicae, 8 parts of Polygala tenuifolia, 10 parts of Citrus aurantium; or, Uncaria rhynchophylla 8 parts, Sarcandra scabra 10 parts, Herba Lycopodii 15 parts, Sanguisorba officinalis 2 parts, Olibanum 6 parts, Root of Trichosanthes kirilowii 12 parts, Radix Bupleuri 6 parts, Rheum officinale 8 parts, Flos Inulae 7 parts, Radix Polygalae 6 parts, Pilosulae citri reticulatae 8 parts; or, Uncaria rhynchophylla 6 parts, Sarcandra scabra 9 parts, Herba Lycopodii 13 parts, Sanguisorba officinalis 1 part, Olibanum 5 parts, Root of Trichosanthes kirilowii 10 parts, Radix Bupleuri 5 parts, Rheum officinale 6 parts, Flos Inulae 6 parts, Tenuifolia tenuifolia 5 parts, Pilosula citri reticulatae 7 parts; or, Uncaria rhynchophylla 7 parts, Sarcandra scabra 11 parts, Herba Lycopodii 18 parts, Sanguisorba officinalis 2 parts, Olibanum 7 parts, Root of Trichosanthes kirilowii 13 parts, Radix Bupleuri 7 parts, Rheum officinale 9 parts, Flos Inulae 8 parts, Radix Polygalae 7 parts, Pilosulae citri reticulatae 9 parts; or, Uncaria rhynchophylla 5 parts, Sarcandra scabra 8 parts, Herba Lycopodii 12 parts, Sanguisorba officinalis 1 part, Olibanum 3 parts, Root of Trichosanthes kirilowii 10 parts, Radix Bupleuri 3 parts, Rheum officinale 5 parts, Flos Inulae 5 parts, Radix Polygalae 3 parts, Pilosulae citri reticulatae 5 parts; or, 9 parts of Uncaria rhynchophylla, 10 parts of Sarcandra scabra, 16 parts of Herba Lycopodii, 3 parts of Sanguisorba officinalis, 5 parts of Olibanum, 14 parts of Radix Trichosanthis, 6 parts of Radix Bupleuri, 7 parts of Radix Rhei, 6 parts of Flos Inulae, 6 parts of Radix Polygalae, 8 parts of Pilosulae Citrus.

[0007] The Chinese medicine composition is Chinese medicine granules or decoction.

[0008] The preparation method of the Chinese medicine granules is as follows: after cleaning and drying the medicinal materials, the medicinal materials are chopped, put into a casserole for decoction, filtered, and the filtrate is harvested, the filtrate is concentrated into an extract, and the extract is mixed with a flavoring agent and an excipient and then granulated; the excipient is dextrin or starch; The preparation method of the decoction is as follows: after cleaning, drying and chopping the medicinal materials, soaking the processed raw materials in water for 30-60 minutes, boiling them with high fire, decocting them for the first time at 80-100° C. for 10-15 minutes, pouring out 1 / 3-1 / 2 of the medicinal liquid; then adding water to the original volume, decocting them for the second time for 10-15 minutes, the decoction temperature range is 60-80° C., then pouring out all the medicinal liquid, mixing the two medicinal liquids to obtain the decoction.

[0009] In the preparation process of the decoction, the amount of water added during decoction is enough to cover all the Chinese medicinal materials by 3-5 cm; specifically, the medicinal materials are first fully absorbed with water and then put into the casserole, and water is added until all the Chinese medicinal materials are covered by 3-5 cm.

[0010] In the present invention, the pretreatment and processing methods of various medicinal materials are detailed in the "Chinese Pharmacopoeia 2010 Edition".

[0011] The medicinal materials that need to be pre-processed or pre-processed are as follows: Wine rhubarb: Wine rhubarb is rhubarb processed with rice wine through special techniques. Take rhubarb slices or pieces, spray with rice wine and mix well, and let it simmer for a while. After the wine is absorbed, put it in a frying container and fry it over a slow fire until it is dry. The color deepens, take it out and let it cool, sieve out the debris, and you will get wine rhubarb. After processing, the laxative effect is slightly slowed down, and the wine can be used to guide the medicine upward by the lifting nature of wine, and it is used to treat diseases of the upper part of the body.

[0012] (III) Beneficial effects This prescription integrates the essence of Huoluo Xielingdan in "Medical Records of Chinese and Western Medicine", Xuanfuhua Decoction in "Golden Chamber", and Chaihuyin in "Shengji Zonglu", and combines it with modern pharmacological research to form a four-dimensional treatment method of promoting blood circulation and relieving pain, clearing away heat and detoxifying, resolving phlegm and dispersing nodules, and promoting qi and relieving numbness.

[0013] The above-mentioned formula can promote blood circulation and relieve pain, clear away heat and detoxify, resolve phlegm and disperse nodules, and promote qi and relieve numbness.

[0014] The beneficial effects of the present invention are: 1. The Chinese medicine composition of the present invention, from the aspect of nature and flavor, is mainly bitter and sweet, with pungent, salty and sour, and the medicinal property is slightly warm, cold and cool, and various drugs cooperate with each other, treat both the symptoms and the root causes, and adjust the deficiency and excess. The whole prescription is based on the principle of monarch, minister, assistant and envoy, and the compatibility is rigorous and reasonable, with clear levels. Its core purpose is to resolve phlegm and dissipate stagnation, promote qi and relieve numbness, and reconcile the heart and kidney, so that qi and blood can flow freely, blood stasis can be dispersed, and the effects of promoting blood circulation and removing blood stasis, dredge the meridians and calm the mind are played together, which is closely consistent with the pathological mechanism of myocardial trabeculation, and achieves cause treatment.

[0015] 2. Experiments have shown that the Chinese medicine composition of the present invention can effectively enhance myocardial contractility, improve myocardial microcirculation, significantly relieve myocardial ischemia and hypoxia, and then fully regulate cardiac function, greatly alleviating clinical symptoms such as palpitations and chest tightness in patients when treating myocardial trabeculosis. DETAILED DESCRIPTION

[0016] In order to better explain the present invention and facilitate understanding, the present invention is described in detail through specific implementation methods.

[0017] The invention provides a traditional Chinese medicine composition for treating excessive myocardial trabeculation. The composition is prepared from the following traditional Chinese medicines in parts by weight: 5-10 parts of Uncaria rhynchophylla, 8-12 parts of Sarcandra scabra, 12-20 parts of Ranunculaceae, 1-6 parts of Sanguisorba officinalis, 3-8 parts of frankincense, 10-15 parts of Trichosanthes root, 3-8 parts of Bupleurum chinense, 5-10 parts of Rheum officinale, 5-10 parts of Inula japonica, 3-8 parts of Polygala tenuifolia and 5-10 parts of Citrus aurantium.

[0018] The present invention is solved as follows: Patients with myocardial trabeculosis have symptoms such as insufficient heart and spleen, stagnation of liver qi, spleen dysfunction, insufficient source of qi and blood biochemical transformation, poor qi and blood circulation, inability to transform water and dampness, endogenous phlegm and dampness, insufficient heart qi and blood, and phlegm stasis and evil qi blocking the heart meridian for a long time. Therefore, the Chinese medicine composition of the present invention uses Uncaria rhynchophylla, Sarcandra chinensis, and Herba Cat's Claw as the main medicine, Sanguisorba officinalis, Olibanum, and Root of Trichosanthes as the ministerial medicine, Bupleurum, Rhubarb, and Flos Inulae as the adjuvant medicine, and Polygala tenuifolia and Citrus aurantium as the guiding medicine.

[0019] Among them, the main herb Uncaria rhynchophylla is an important medicine for calming the liver and extinguishing wind. Modern research shows that its Uncarine can regulate the calcium ion channels of myocardial cells, and has a significant effect on the pathogenesis of "liver wind disturbing the collaterals" caused by abnormal myocardial hyperplasia; Sarcandra chinensis: bitter and pungent in nature, it can both promote blood circulation and eliminate symptoms as well as clear away heat and detoxify. The isoflurane contained in it can inhibit abnormal collagen deposition; Cat's Claw: salty and pungent in nature, it can resolve phlegm and disperse nodules. Its polysaccharide components can regulate myocardial cell apoptosis. The three main herbal medicines are used together to eliminate phlegm and blood stasis, calm wind and inhibit hyperplasia. The three medicines work together to promote blood circulation, dredge collaterals, resolve phlegm and disperse nodules.

[0020] The frankincense in the auxiliary medicine can promote blood circulation, remove blood stasis and relieve pain. Its fat-soluble components penetrate the blood-brain barrier and reach the myocardial microcirculation directly. Sanguisorba officinalis also has the effect of promoting blood circulation, removing blood stasis and relieving pain. Its water extract inhibits platelet aggregation. Sanguisorba officinalis and frankincense work together to achieve the effect of "removing blood stasis and promoting new blood". Trichosanthes root: also known as Trichosanthes kirilowii, can both clear away heat and promote fluid production as well as remove blood stasis and disperse nodules. Its Trichosanthes kirilowii protein can regulate myocardial energy metabolism, forming a "blood stasis and heat treatment" pattern with Sanguisorba officinalis and frankincense. The three auxiliary medicines work together to promote blood circulation, remove blood stasis, disperse nodules and clear heat.

[0021] The adjuvants, bupleurum and rhubarb, constitute the ascending and descending pivot. Bupleurum relieves liver qi and leads the medicine into the meridians, while rhubarb clears the bowels and relieves heat, and the blood circulation is enhanced after being processed with wine, which is in line with the pathological characteristics of "liver depression transforming into fire, and obstruction of bowel qi". Inula flower can eliminate phlegm and lower qi, and contains inula flower extract to promote myocardial microvascular regeneration. The three adjuvants work together to relieve liver evil heat and clear blood stasis.

[0022] Auxiliary drug: Polygala tenuifolia: It is an important drug for resolving phlegm and connecting the heart and kidneys. Its polygala tenuifolia saponins can regulate the autonomic nervous function and improve the symptoms related to arrhythmia; Citrus reticulatae can dredge the meridians, and citrus flavonoids can improve myocardial compliance. The two auxiliary drugs work together to achieve the effects of resolving phlegm, unblocking the meridians and relieving arthritis.

[0023] The functions of the above components in the Chinese medicine composition of the present invention are as follows: Uncaria rhynchophylla: "Compendium of Materia Medica" states that "Uncaria rhynchophylla can dispel wind and resolve phlegm, calm epilepsy, soothe guests, and treat smallpox." "New Compilation of Materia Medica" states that "Uncaria rhynchophylla can dispel wind very quickly, and it is a must-have for those with wind diseases." This medicine tastes sweet and bitter, and is slightly cold. It enters the heart and liver meridians. It has the effects of clearing heat and calming the liver, extinguishing wind and calming convulsions. Pharmacological studies have shown that it has the effects of lowering blood pressure, calming and anticonvulsant.

[0024] Sarcandra glabra: The dried whole plant of Sarcandra glabra of the family Chrysanthemiaceae is recorded in the Classification of Herbal Medicinal Properties as "treating all injuries from falls, rheumatism, numbness, and pain in the tendons and bones." This medicine tastes pungent, bitter, and flat. It enters the heart and liver meridians. It has the effects of clearing away heat and cooling blood, promoting blood circulation and removing spots, and dispelling wind and unblocking collaterals. Pharmacological studies have shown that it has anti-inflammatory, anti-cancer, and immune-regulating effects.

[0025] Cat's Claw: This medicine is sweet, spicy and warm. It enters the liver and lung meridians. It has the effects of resolving phlegm and dispersing nodules, detoxifying and reducing swelling. Pharmacological studies have shown that it has anti-inflammatory, blood pressure lowering, anti-tumor, and anti-tuberculosis effects.

[0026] Xuejie: ​​"Jingyue Complete Works" records that it "tastes sweet, salty, slightly astringent, and is neutral in nature. It is good at breaking up blood stasis, relieving pain and promoting tissue regeneration. It can treat wounds, fractures, blood stasis and pain, internal injuries, blood reversal, and blood stagnation in women. It can also promote blood production and replenish deficiency. It can be ground into powder and taken with wine. It can also treat all kinds of malignant sores, scabies, and long-term discomfort. However, it can induce pus, so it should not be used too much." This medicine tastes sweet, salty, and neutral. It enters the heart and liver meridians. Efficacy: It promotes blood circulation and relieves pain, removes blood stasis and stops bleeding, promotes tissue regeneration and heals sores. Pharmacological studies have shown that its extract has the effect of dilating blood vessels and increasing vascular permeability.

[0027] Frankincense: "Jingyue Complete Works" records that it "tastes bitter and pungent, is warm in nature, and slightly hot. It can ward off evil spirits, treat cholera, unclog blood vessels, stop the pain of bloody diarrhea in the large intestine, and women's qi reversal and blood stasis, heart and stomach pain, eliminate carbuncle poisons, protect the heart, promote blood circulation and relieve pain, relax tendons and veins, and treat fractures. Decoction of the ointment can relieve pain and grow flesh." This medicine tastes pungent, bitter, and warm, and it enters the heart, liver, and spleen meridians. Efficacy: promoting blood circulation and relieving pain, reducing swelling and promoting tissue regeneration. Pharmacological studies have shown that its extract has the effect of dilating blood vessels and increasing vascular permeability.

[0028] Trichosanthes root: The sliced ​​root of Trichosanthes root is Radix Trichosanthis. The "Medical Records of Chinese and Western Medicine" states that "it can produce body fluids and quench thirst, so it can moisten the lungs, resolve dry phlegm in the lungs, calm the lungs and stop coughs, treat lung tuberculosis, and is good at clearing the meridians and relieving all heat toxins in sores." "Ben Jing Feng Yuan" states that "Trichosanthes root can reduce hot phlegm on the diaphragm, moisten the heart and relieve thirst, eliminate seasonal fever, eliminate alcohol and dampness, treat carbuncle, detoxify and discharge pus." This medicine tastes sweet, slightly bitter, and slightly cold. It belongs to the lung and stomach meridians. Efficacy: clearing heat and producing body fluids, moistening the lungs and resolving phlegm, reducing swelling and discharging pus. Pharmacological studies show that it has anti-tumor, immune regulation, and antiviral effects.

[0029] Bupleurum: Compendium of Materia Medica states that "there are five types of fatigue, and the diseases are in the five internal organs. If the fatigue is in the liver, gallbladder, heart and pericardium with heat, or if the Shaoyang meridian is cold or hot, then Bupleurum is a must-use medicine for the Jueyin and Shaoyang meridians of the hands and feet." "Explanation of Materia Medica" states that "Bupleurum is used to treat qi stagnation in the heart, abdomen, intestines and stomach. The heart, abdomen, intestines and stomach are the five zang organs and six fu organs. There are twelve meridians in the zang fu organs, and all eleven zang organs depend on the gallbladder. Bupleurum is light and clear, and it can promote the gallbladder qi. When the gallbladder qi is smooth, the eleven zang organs will follow it. Therefore, all qi stagnation in the heart, abdomen, intestines and stomach can be dispersed." This medicine tastes bitter and cool, and it belongs to the heart, liver and spleen meridians. It has the effect of reconciling the exterior and interior, soothing the liver and raising yang. Pharmacological studies have shown that its extract has anticonvulsant, blood pressure lowering, and anti-inflammatory effects.

[0030] Wine rhubarb: Shennong's Herbal Classic states that it "can relieve blood stasis, blood stasis, cold and heat, break up accumulation of tumors, retain food and drink, cleanse the intestines and stomach, remove the old and bring in the new, promote the flow of water and food, regulate the digestion of food, and calm the five internal organs." Rihuazi's Herbal Classic states that it "can promote the flow of all qi, regulate blood vessels, benefit joints, relieve plastic stagnation, water vapor, cold and hot limbs, warm miasma and hot phlegm, promote urination and defecation, and remove sores, carbuncle and carbuncle poison." This medicine tastes bitter and cold. It enters the pericardium, spleen, stomach, and large intestine meridians, and has the effects of clearing blood in the upper jiao and separating heat and poison. Pharmacological studies have shown that it has the effects of stopping bleeding, lowering blood lipids, and improving microcirculation.

[0031] Inula flower: "Shennong's Herbal Classic" records that it "mainly treats qi stagnation, hypochondrium, palpitations, water removal, cold and heat between the five internal organs, tonifying the middle and lowering qi." "Bencao Jing Jizhu" "mainly treats qi stagnation, hypochondrium, palpitations, water removal, cold and heat between the five internal organs, tonifying the middle and lowering qi. Eliminate phlegm in the chest, saliva like glue, phlegm and water in the heart and hypochondrium, bladder retention, wind and dampness, dead flesh between the skin, mucus in the eyes, benefit the large intestine, dredge blood vessels, and improve color." This medicine tastes bitter, pungent, and salty, and is slightly warm in nature. It belongs to the lung, spleen, stomach, and large intestine meridians. It descends qi, eliminates phlegm, promotes water flow, and stops vomiting. Pharmacological studies have shown that it has expectorant and antibacterial effects, and the quercetin it contains can increase coronary flow.

[0032] Polygala: "Shennong's Herbal Classic" records that it "treats cough, reverses the body, injures the middle, replenishes deficiency, removes evil spirits, benefits the nine orifices, improves wisdom, makes the ears and eyes sharp, prevents forgetfulness, strengthens the will and doubles strength." "New Compilation of Materia Medica" records that it "can detoxify, calm the mind, calm the mind and improve intelligence. Taking more can improve memory and stop nocturnal emissions. It is a medicine for the heart meridian and can cure all heart meridian deficiency diseases. However, it is not limited to treating the heart. It can also cure diseases of the liver, spleen, and lungs." This medicine tastes bitter, pungent, warm, and enters the heart and kidney meridians. Efficacy: calms the mind, improves intelligence, removes phlegm, relieves depression, and connects the heart and kidney. Pharmacological studies have shown that its extract has anticoagulant, sedative, anti-cancer, and diuretic effects.

[0033] Tangerine peel: "Compendium of Materia Medica" records that it "can clear the meridians and stagnate qi, distend the pulse, drive away the phlegm accumulated outside the skin and membrane, and activate blood circulation." "Compendium of Materia Medica Chongyuan" records that "the fascia on the tangerine pulp can cure thirst and vomiting of alcohol, and it is very effective to drink it in decoction, because it can move the drink in the chest to the skin." This medicine tastes bitter, sweet, and flat, and it belongs to the spleen and lung meridians. It has the effect of clearing the meridians, promoting qi and resolving phlegm. Pharmacological studies have shown that its extract has the effects of lowering blood lipids, anti-tumor, improving microcirculation, and anti-oxidation.

[0034] The Chinese medicine composition of the present invention, i.e. the decoction of the present application, is analyzed from the aspect of nature and flavor, and the taste of the medicine is mainly bitter and sweet, with pungent, salty and sour, and the property of the medicine is slightly warm, and cold and cool are also used. Various types of medicines cooperate with each other, treat both the symptoms and the root causes, and adjust the deficiency and excess together. The whole prescription is based on the principle of monarch, minister, assistant and messenger, and the compatibility is rigorous and reasonable, with clear levels. Its core purpose is to resolve phlegm and dissipate stagnation, promote qi and relieve numbness, and reconcile the heart and kidney, so that qi and blood can flow freely, and blood stasis can be dispersed by itself, and the effects of promoting blood circulation and removing blood stasis, dredge the meridians and calm the heart are played together, and the pathological mechanism of myocardial trabeculation is closely matched. Experiments show that the Chinese medicine composition of the present invention can effectively enhance myocardial contractility, improve myocardial microcirculation, significantly alleviate myocardial ischemia and hypoxia, and then fully regulate cardiac function, greatly reducing the clinical symptoms such as palpitations and chest tightness of patients.

[0035] The following is an explanation of the preferred embodiments and technical effects of the present invention. The decoction or granules prepared according to the dosage given in each embodiment and comparative example are all one dose.

[0036] Example 1 This embodiment provides a Chinese medicine decoction of a Chinese medicine composition for treating excessive myocardial trabeculation, and the preparation method thereof is as follows: S1. Weigh: Uncaria rhynchophylla 10g, Sarcandra sylvestris 12g, Cat's Claw 20g, Sanguisorba officinalis 6g, Frankincense 8g, Trichosanthes root 15g, Bupleurum 8g, Rhubarb 10g, Inula flower 10g, Polygala tenuifolia 8g, Citrus aurantium 10g.

[0037] S2. The preparation method of the decoction is as follows: After cleaning, drying and chopping each medicinal material, soak the processed raw materials in water for 60 minutes, put the medicinal materials into a casserole after saturating them with water, and add water until all the Chinese medicinal materials are submerged by 5 cm. After boiling over high heat, decoct at 90°C for 15 minutes for the first time, pour out 1 / 2 of the liquid medicine; then add water to the original volume, decoct for a second time for 15 minutes, the decoction temperature range is 70°C, and then pour out all the liquid medicine, mix the two liquid medicines, filter, and obtain a clear and transparent decoction.

[0038] Example 2 This embodiment provides a Chinese medicine decoction for treating excessive myocardial trabeculation, and the preparation method thereof is as follows: S1. Weighing: Uncaria rhynchophylla 8g, Sarcandra scabra 10g, Radix catnip 15g, Sanguisorba officinalis 2g, Frankincense 6g, Trichosanthes root 12g, Bupleurum 6g, Rheum officinale 8g, Inula 7g, Polygala tenuifolia 6g, Citrus aurantium 8g; S2. After cleaning, drying and chopping the herbs, soak the treated raw materials in water for 30 minutes, let the herbs absorb water first and then put them into the casserole, add water to cover all the herbs by 5 cm. After boiling over high heat, boil at 80℃ for 15 minutes for the first time, pour out 1 / 2 of the liquid medicine; add water to the original volume, boil for the second time for 15 minutes, the boiling temperature range is 80℃, and then pour out all the liquid medicine, mix the two liquid medicines, filter, and obtain a clear and transparent decoction.

[0039] Example 3 This embodiment provides a Chinese medicine decoction for treating excessive myocardial trabeculation, and the preparation method thereof is as follows: S1. Weigh: Uncaria rhynchophylla 6g, Sarcandra scabra 9g, Cat's claw herb 13g, Sanguisorba officinalis 1g, Frankincense 5g, Trichosanthes root 10g, Bupleurum 5g, Rheum officinale 6g, Inula 6g, Polygala tenuifolia 5g, Citrus aurantium 7g; S2. The preparation method of the decoction is as follows: After cleaning, drying and chopping each medicinal material, soak the processed raw materials in water for 40 minutes, put the medicinal materials into a casserole after saturating them with water, and add water until all the Chinese medicinal materials are submerged by 4 cm. After boiling over high heat, decoct at 90°C for 10 minutes for the first time, pour out 1 / 3 of the liquid medicine; then add water to the original volume, decoct for a second time for 10 minutes, the decoction temperature range is 75°C, and then pour out all the liquid medicine, mix the two liquid medicines, filter, and obtain a clear and transparent decoction.

[0040] Example 4 This embodiment provides a Chinese medicine decoction for treating excessive myocardial trabeculation, and the preparation method thereof is as follows: S1. Weighing: Uncaria rhynchophylla 7g, Sarcandra scabra 11g, Cat’s Claw 18g, Sanguisorba officinalis 2g, Frankincense 7g, Trichosanthes root 13g, Bupleurum 7g, Rhubarb 9g, Inula 8g, Polygala tenuifolia 7g, Citrus aurantium 9g; S2. The preparation method of the decoction is as follows: After cleaning, drying and chopping each medicinal material, soak the processed raw materials in water for 50 minutes, put the medicinal materials into a casserole after saturating them with water, and add water until all the Chinese medicinal materials are submerged by 5 cm. After boiling over high heat, boil at 80°C for 15 minutes for the first time, pour out 1 / 2 of the liquid medicine; then add water to the original volume, boil for the second time for 10 minutes, the boiling temperature range is 70°C, and then pour out all the liquid medicine, mix the two liquid medicines, filter, and obtain a clear and transparent decoction.

[0041] Example 5 This embodiment provides a Chinese medicine granule for treating excessive myocardial trabeculation, and the preparation method thereof is as follows: S1. Weigh: Uncaria rhynchophylla 5g, Sarcandra scabra 8g, Cat’s Claw 12g, Sanguisorba officinalis 1g, Frankincense 3g, Trichosanthes root 10g, Bupleurum 3g, Rheum officinale 5g, Inula 5g, Polygala tenuifolia 3g, Citrus aurantium 5g; S2. The preparation method of the granules is as follows: after cleaning and drying each medicinal material, chop it into pieces, put it into a casserole, boil it, filter it, harvest the filtrate, concentrate the filtrate into an extract, mix the extract with white sugar and dextrin, and then granulate it.

[0042] Example 6 This embodiment provides a Chinese medicine granule for treating excessive myocardial trabeculation, wherein the drug ingredients are 9g of Uncaria rhynchophylla, 10g of Sarcandra scabra, 16g of Radix Ranunculi, 3g of Sanguisorba officinalis, 5g of Olibanum, 14g of Trichosanthes root, 6g of Bupleurum chinense, 7g of Rheum officinale, 6g of Inula japonica, 6g of Polygala tenuifolia, and 8g of Citrus aurantium. The preparation method is the same as that of Example 5.

[0043] Comparative Example 1 This comparative example provides a Chinese medicine decoction for treating excessive myocardial trabeculation, and the preparation method thereof is as described in Example 1, but the ministerial drug does not contain "Xuejiu and Frankincense", and the ministerial drug only retains "Trichosanthes root"; the adjuvant drug does not contain "Bupleurum", and the wine rhubarb uses ordinary rhubarb instead of wine rhubarb. The Chinese medicine decoction is prepared according to the method of Example 1.

[0044] Clinical trials 1. Case source Case sources: A total of 240 patients with excessive myocardial trabeculation who visited the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine and the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 1, 2014 to December 31, 2024 were collected.

[0045] 2. Diagnostic criteria: 1) Western medicine diagnostic criteria: The Jenni cardiac ultrasound diagnostic criteria, which is currently the most widely used in the world, can be diagnosed only if the following four conditions are met: ① Two different myocardial layers appear; ②Prominent myocardial trabeculae and deep intertrabecular recesses; ③ The ratio of trabecular myocardium to compact myocardium at the end of systole is >2:1; ④No other cardiac malformations.

[0046] 2) TCM diagnostic criteria: According to the "Guidelines for Clinical Research of New Chinese Medicines (2002)", the TCM diagnostic criteria for excessive myocardial trabeculation are as follows: Main symptoms: chest tightness; fatigue; palpitations; Secondary symptoms: spontaneous sweating; fear of cold; shortness of breath; dark purple lips; difficulty urinating; Tongue and pulse: The tongue is dark purple, enlarged or has teeth marks, and the pulse is thin, slow and weak; Note: The patient must have at least 2 of the main symptoms and at least 1 of the secondary symptoms, and the diagnosis can be made based on the tongue and pulse.

[0047] 3) TCM Syndrome Points Table: Each of the above symptoms is divided into four levels: asymptomatic, mild, moderate, and severe. The main symptoms are assigned 0, 2, 4, and 6 points, and the secondary symptoms are assigned 0, 1, 2, and 3 points. For those with tongue and pulse conditions, each item is scored as 1 point.

[0048] 3. Inclusion criteria: ① Meet the above-mentioned Western medical diagnostic criteria; ②Meet the above-mentioned TCM diagnostic criteria; ③New York Heart Association (NYHA) heart function grade II to IV; ④Age 18-75, no gender limitation; ⑤ Have complete clinical treatment data; ⑥ Voluntarily participate in this clinical trial, understand and sign the informed consent form.

[0049] 4. Exclusion criteria: ① Patients with acute coronary syndrome within 30 days before enrollment; ② Patients who have received or are expected to receive implantable devices such as ICD, CRT during the trial period, or undergo revascularization within 3 months, such as PCI, CABG, and other cardiac or cardiovascular surgeries; ③Combined with severe primary diseases of the liver, kidney, hematopoietic system, tumors, mental illness, or other uncontrolled systemic diseases; ④ The patient has uncontrollable arrhythmia, active myocarditis, constrictive pericarditis, immune and inflammatory-mediated myocardial damage, etc.; ⑤ ALT, AST ≥ 1.5 times the upper limit of normal value, Scr > 1.2 times the upper limit of normal value, and abnormal blood potassium that is difficult to correct; ⑥ Patients with hypertension that is difficult to control with medication, systolic blood pressure ≥ 180 mmHg and / or diastolic blood pressure ≥ 110 mmHg; ⑦ Women who are pregnant or preparing to become pregnant or breastfeeding; ⑧People with allergic constitution or known allergy to the ingredients of the treatment drugs; ⑨Participating in other drug clinical research within 3 months.

[0050] 5. Elimination, falling off and termination standards: ①Those who were lost to follow-up or did not come to the hospital for follow-up on time; ② During the treatment period, the condition is not well controlled and additional medication is required: 1) patients with pleural effusion, ascites, and pericardial effusion; 2) patients with heart function grade increased by more than 2 grades; ③ Those who receive other drug treatment during the trial; ④ Those who develop serious complications during the trial; ⑤ Serious safety issues occur during the trial; ⑥ During the trial, serious deviations occur from the research plan.

[0051] 6. Test methods (1) Grouping method: According to the random principle, the patients were divided into a control group of 80 cases, an experimental group of 80 cases, and a comparison group of 80 cases. During the trial, due to various reasons, the patients were excluded, dropped out, or terminated. Finally, the number of effective cases in the control group, experimental group, and comparison group was 72, 68, and 64, respectively. For the convenience of research, 60 cases were randomly selected from each of the three groups as statistical objects and the experimental results were given.

[0052] (2) Treatment methods: 1) General treatment: Basic treatment is given, including disease-related education, low-salt and low-fat diet, smoking cessation and alcohol restriction, moderate exercise, avoidance of wind and cold, emotional regulation, and careful daily life.

[0053] 2) Drug treatment: Treatment plan for the control group: conventional symptomatic treatment to improve fluid retention, inhibit ventricular remodeling, etc. to solve the cause: ① Bisoprolol fumarate tablets, manufacturer: Beijing Huasu Pharmaceutical Co., Ltd., specifications: 5 mg × 10 tablets, dosage: maintenance dose is 10 mg, once a day; medication time: around 7:00 in the morning.

[0054] ②Sacubitril / valsartan sodium tablets, manufacturer: Beijing Novartis Pharmaceuticals Co., Ltd., specifications: 100 mg × 14 tablets, dosage: 1 tablet each time, once a day; time of taking medicine: around 7:00 in the morning.

[0055] ③ Spironolactone tablets, manufacturer: Hangzhou Minsheng Pharmaceutical Co., Ltd., specifications: 20 mg × 100 tablets, dosage: 20 mg each time, twice a day; medication time: around 7:00 in the morning and around 19:00 in the evening.

[0056] The experimental group was given the Chinese medicine decoction of Example 1 on the basis of the control group. The decoction prepared according to this example was one dose, and the usage was one dose per day, divided into two times, taken warm in the morning and evening.

[0057] The control group was given the Chinese medicine decoction of comparative example 1 on the basis of the control group. The decoction prepared according to the comparative example 1 was one dose. Usage: one dose per day, divided into two times, taken warm in the morning and evening.

[0058] Treatment course: One treatment cycle is 8 weeks. Clinical data are collected at the beginning and end of the treatment to observe the changes before and after taking the medicine.

[0059] (3) Observation indicators 1) Safety indicators: Blood routine, liver and kidney function, electrolytes, blood lipids, urine and stool routine tests (once before and after treatment).

[0060] 2) Efficacy indicators: ①Echocardiographic examination; ②Serum amino-terminal pro-brain natriuretic peptide NT-proBNP; ③TCM syndrome score; ④NYHA new functional classification level; 3) Criteria for determining efficacy: ① Criteria for judging the efficacy of TCM syndromes: According to the nimodipine efficacy evaluation criteria: efficacy index = [(total score of symptoms before treatment - total score of symptoms after treatment) / total score of symptoms before treatment] X 100% Markedly effective: clinical symptoms and signs are significantly improved, and the therapeutic index is reduced by ≥70%; Effective: clinical symptoms and signs improved, 70%>therapeutic index decreased ≥30%; Ineffective: Clinical symptoms and signs did not improve, or even worsened, and the therapeutic index decreased by <30%.

[0061] ② Evaluation criteria for cardiac function efficacy obtained according to NYHA classification standards: Markedly effective: The patient's symptoms are basically relieved and / or the cardiac function improves by ≥2 levels; Effective: The patient's cardiac function improved by more than 1 grade but less than 2 grades; Ineffective: The patient's cardiac function improved by ≤1 grade; Aggravation: The patient's heart function declines by ≥ 1 grade.

[0062] 7. Statistical analysis: SPSS 25.0 statistical software was used for analysis and processing, and the quantitative data were t Test, expressed as mean ± standard deviation, rank sum test for unequal variance, rank sum test for ranked data, and chi-square test for count data. P <0.05 was considered to be significantly different.

[0063] 8. Test results ① Comparison of general information of patients in the control group, experimental group and comparison group is shown in Table 1.

[0064] Table 1: Comparison of general information between the control group and the experimental group ; Table 1 shows that there was no statistically significant difference in gender and age among the control group, experimental group and comparison group (P>0.05), and the three groups were comparable.

[0065] ② Comparison of the main TCM symptom scores of patients before and after treatment, see Table 2.

[0066] Table 2: Comparison of the main TCM symptom scores of the three groups of patients before and after treatment: control group, experimental group and comparison group ( ±s) ; Note: a: The main TCM symptom scores after treatment were compared with those in the control group, P < 0.05; b: The main TCM symptom scores after treatment were compared with those in the control group, P < 0.05; c: The main TCM symptom scores of each group were compared before and after treatment, P < 0.05.

[0067] Before treatment, there was no statistically significant difference in the scores of the main TCM symptoms (chest tightness, fatigue, palpitations) of the three groups of patients in the control group, the experimental group, and the comparison group, and they were comparable (P>0.05). After treatment, the scores of the main TCM symptoms (chest tightness, fatigue, palpitations) of the three groups of patients were lower than before, and the TCM syndrome scores of the experimental group and the comparison group were significantly lower than those of the control group, and the TCM syndrome scores of the experimental group were significantly lower than those of the comparison group, and the difference was statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can better improve the main TCM clinical symptoms of patients with excessive myocardial trabeculation, namely chest tightness, fatigue, and palpitations.

[0068] ③ Comparison of the minor TCM symptom scores of patients before and after treatment, see Table 3.

[0069] Table 3: Comparison of minor TCM symptom scores before and after treatment in the control group, experimental group and comparison group ( ±s) ; Note: a: After treatment, the minor TCM symptom scores were compared with those of the control group, P < 0.05; b: After treatment, the minor TCM symptom scores were compared with those of the control group, P < 0.05; c: Comparison of the minor TCM symptom scores of each group before and after treatment, P < 0.05.

[0070] Before treatment, there was no significant difference in the scores of the minor TCM symptoms of the control group, the experimental group, and the comparison group, and they were comparable (P>0.05). After treatment, the scores of the minor TCM symptoms of spontaneous sweating, fear of cold, shortness of breath, purple lips, and difficulty urinating in the control group, the experimental group, and the comparison group were all lower than before. The scores of the minor TCM syndromes in the experimental group and the comparison group were significantly lower than those in the control group, and the scores of the minor TCM syndromes in the experimental group were significantly lower than those in the comparison group, and the differences were statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can better improve the minor TCM clinical symptoms of patients with excessive myocardial trabeculation, namely, spontaneous sweating, fear of cold, shortness of breath, purple lips, and difficulty urinating.

[0071] ④ Comparison of TCM syndrome scores before and after treatment in the control group, experimental group and comparison group, see Table 4.

[0072] Table 4: Comparison of TCM syndrome scores among the three groups of patients before and after treatment ( ±S) ; Note: a: TCM symptom scores after treatment were compared with those in the control group, P < 0.05; b: TCM symptom scores after treatment were compared with those in the control group, P < 0.05; c: TCM symptom scores of each group were compared before and after treatment, P < 0.05.

[0073] Before treatment, there was no significant difference in the TCM symptom scores of the three groups of patients, which were comparable (P>0.05). After treatment, the TCM symptom scores of the three groups of patients were lower than before, and the TCM symptom scores of the experimental group and the control group were significantly lower than those of the control group, and the TCM symptom scores of the experimental group were significantly lower than those of the control group, and the difference was statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can better improve the clinical symptoms of patients with excessive myocardial trabeculation and improve the quality of life of patients.

[0074] ⑤ Comparison of the efficacy of TCM syndromes in the control group, experimental group and comparison group before and after treatment, see Table 5.

[0075] Table 5: Comparison of the efficacy of TCM syndromes in the control group, experimental group and comparison group before and after treatment Table 5: Comparison of the efficacy of TCM syndromes in the three groups of patients before and after treatment ; Note: a: The efficacy of TCM syndrome after treatment was compared with that of the control group, P < 0.05; b: The efficacy of TCM syndrome after treatment was compared with that of the control group, P < 0.05.

[0076] As can be seen from the above table, after 8 weeks of treatment, the total effective rate of TCM syndrome efficacy in the experimental group was 83.33% (50 / 60), which was higher than 71.67% (43 / 60) in the comparison group and 56.67% (34 / 60) in the control group. The difference was statistically significant (P<0.05).

[0077] ⑥ Comparison of NYHA cardiac function efficacy among the control group, experimental group and comparison group, see Table 6.

[0078] Table 6: Comparison of NYHA cardiac function efficacy among the three groups of patients before and after treatment ; Note: a: The NYHA cardiac function efficacy after treatment was compared with that in the control group, P < 0.05; b: The NYHA cardiac function efficacy after treatment was compared with that in the control group, P < 0.05.

[0079] As can be seen from the above table, after 8 weeks of treatment, the total effective rate of NYHA cardiac function in the experimental group was 93.33% (56 / 60), which was higher than 78.33% (47 / 60) in the comparison group and 66.67% (40 / 60) in the control group. The difference was statistically significant (P<0.05).

[0080] ⑦ Comparison of NT-proBNP levels in the control group, experimental group and comparison group before and after treatment, see Table 7.

[0081] Table 7: Comparison of NT-proBNP among three groups of patients ( ±S) ; Note: a: NT-proBNP after treatment was compared with that in the control group, P < 0.05; b: NT-proBNP after treatment was compared with that in the control group, P < 0.05; c: NT-proBNP before and after treatment in each group, P < 0.05.

[0082] Before treatment, there was no significant difference in the NT-proBNP levels among the three groups of patients, and they were comparable (P>0.05). After treatment, the NT-proBNP levels in the three groups of patients were lower than before, and the NT-proBNP levels in the experimental group and the control group were significantly lower than those in the control group, and the NT-proBNP level in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can effectively reduce the NT-proBNP level in patients with excessive myocardial trabeculation.

[0083] ⑧ Comparison of echocardiograms among the control group, experimental group and comparison group, see Table 8.

[0084] Table 8: Comparison of echocardiograms among the three groups of patients ( ±S) ; Note: LVEF: left ventricular ejection fraction; LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter. a: After treatment, the echocardiographic indexes were compared with those in the control group, P < 0.05; b: After treatment, the echocardiographic indexes were compared with those in the control group, P < 0.05; c: Comparison of echocardiographic indexes before and after treatment in each group, P < 0.05.

[0085] Before treatment, there were no significant differences in the levels of echocardiographic indices (LVEF, LVEDD, LVESD) among the three groups of patients in the control group, experimental group and comparison group, and they were comparable (P>0.05). After treatment, the LVEF levels of the three groups of patients in the control group, experimental group and comparison group were all higher than before, and the LVEF levels of the experimental group and the comparison group were significantly higher than those in the control group, and the LVEF level of the experimental group was significantly higher than that in the comparison group, and the difference was statistically significant (P<0.05). After treatment, the LVEDD and LVESD levels of the three groups of patients in the control group, experimental group and comparison group were all lower than before, and the LVEDD and LVESD levels of the experimental group and the comparison group were significantly lower than those in the control group, and the LVEDD and LVESD levels of the experimental group were significantly lower than those in the comparison group, and the difference was statistically significant (P<0.05). In summary, the Chinese medicine composition of the present invention can better improve the cardiac function of patients with excessive myocardial trabeculation, increase the LVEF level of patients, and reduce the LVEDD and LVESD levels of patients.

[0086] ⑨Safety evaluation: During the four-week treatment period, the biochemical examination indicators, liver function, kidney function, blood routine, urine routine, blood lipids, blood creatinine and other routine examination indicators of the three groups of patients were compared within the group. There was no situation where the indicators were normal before treatment and abnormal after treatment, and the patients did not experience allergic reactions and other adverse reactions.

[0087] Typical treatment cases Case 1: Patient 1, male, 54 years old, was treated for "limited activity with chest tightness and edema for more than 3 months". Symptoms: pale complexion, poor spirit, low voice, chest tightness and breathlessness, aggravation after activity, backache and fatigue, fear of cold and cold limbs, edema of both lower limbs, no dizziness and headache, no chest pain, no dry mouth and bitter mouth, poor appetite, poor sleep, urination, difficult defecation, once every 2 days. Pale tongue, thin white fur, and slow pulse. Check cardiac color Doppler ultrasound: no echo chamber in the left ventricular cavity, myocardial dysplasia, consider excessive myocardial trabeculation. Diagnosed as excessive trabeculation of the left myocardium. Use the Chinese medicine decoction of Example 1, one dose per day, take twice a day, and follow up after 2 months of treatment. The patient's symptoms improved, chest tightness and breathlessness improved, backache and fatigue were alleviated, and there was no edema in both lower limbs. Recheck cardiac color Doppler ultrasound: left ventricular diastolic function decreased and aortic elasticity decreased.

[0088] Case 2: Patient 2, female, 78 years old, was diagnosed with "chest tightness and shortness of breath for more than 2 months, with edema of both lower limbs for 2 weeks". Symptoms: fatigue, chest tightness and shortness of breath, aggravated by movement, unable to lie flat, accompanied by palpitations, cough and sputum, white and sticky sputum, edema of both lower limbs, no dizziness and headache, no dry mouth and bitter taste, good appetite, poor sleep at night, flat bowel movements, pale red tongue, white and greasy fur, slippery pulse. Check the heart color Doppler ultrasound: left ventricular wall echo changes, indicating excessive myocardial trabeculation and left ventricular enlargement. Diagnosed as excessive trabeculation of the left myocardium. Use the Chinese medicine decoction of Example 1, one dose per day, take twice a day, morning and evening, follow up after 2 months of treatment, the patient's spirit is good, occasional chest tightness and shortness of breath, palpitations are better than before, no cough and sputum, no dry mouth and bitter taste, and edema of both lower limbs is alleviated. Recheck the heart color Doppler ultrasound: left ventricular diastolic function is reduced, aortic elasticity is reduced, and the aortic valve is mildly calcified.

[0089] Case 3: Patient 3, female, 36 years old, came to the hospital for "chest tightness and palpitations for more than 3 months". Symptoms: The patient is clear-headed and mentally tired. She often feels chest tightness, as if there is a heavy object pressing on her, and palpitations occur frequently. The symptoms are aggravated after activities and can be slightly relieved by rest. Occasionally, there will be dull pain in the precordial area, which is tingling and fixed in location. Each attack lasts for several minutes. She feels that her breathing is not smooth, her activity endurance is reduced, and she is easily tired. She has no aversion to cold or fever, and no cough or sputum. She has a general appetite, sleeps with many dreams at night, has normal bowel movements, and has normal urination. Her complexion is slightly pale, her tongue is light purple, with petechiae on the edges, her tongue coating is thin and white, and her pulse is thin and astringent. Cardiac ultrasound examination showed: decreased left ventricular diastolic function; thinning of the local myocardium of the right ventricle, thickening of the trabeculae, and excessive trabeculation of the local myocardium. The diagnosis was excessive trabeculation of the myocardium. The Chinese medicine decoction of Example 1 was used, one dose per day, taken twice a day, morning and evening. Follow-up after 2 months of treatment: the patient's self-reported chest tightness and palpitation symptoms were significantly alleviated, the number of precordial stabbing attacks decreased, activity endurance was enhanced, breathing was smoother than before, sleep quality improved, and night dreams decreased. The complexion was ruddy than before, the tongue was still light purple, the color of the petechiae became lighter, the fur was thin and white, and the pulse was thin. Re-examination of cardiac color Doppler ultrasound: left ventricular relaxation function decreased.

[0090] Case 4: Patient 4, male, 42 years old, was treated for "palpitations for more than 1 year". Symptoms: The patient was clear-headed and mentally OK, but often felt palpitations, which worsened after activity, occasional chest pain, fixed pain, shortness of breath, decreased activity tolerance, easy fatigue, no fever and chills, no cough and sputum, normal appetite, frequent dreams at night, regular bowel movements, normal urination, dark purple tongue, ecchymosis on the edges, thin white fur, and astringent pulse. Cardiac ultrasound showed: left heart enlargement, a small amount of mitral valve regurgitation; reduced aortic elasticity, mild calcification of the aortic valve and a small amount of regurgitation; excessive myocardial trabeculation of the posterior wall of the left ventricle. Diagnosed as excessive myocardial trabeculation. The Chinese medicine granules of Example 5 were used, one dose per day, taken twice, and followed up after 2 months of treatment: the self-reported palpitations were significantly alleviated, the number of chest pain attacks decreased, activity tolerance was improved, shortness of breath improved, sleep quality improved, and night dreams decreased. The tongue is slightly darker, the ecchymosis is lighter than before, the fur is thin and white, and the pulse is stringy and thin. Re-examination of the heart color Doppler ultrasound: left heart enlargement, a small amount of mitral valve regurgitation; aortic elasticity is reduced, aortic valve is slightly calcified and has a small amount of regurgitation.

[0091] Case 5: Patient 5, male, 43 years old, was diagnosed with "lower limb edema for 1 month, chest tightness and shortness of breath for 1 day". Symptoms: The patient was conscious and mentally sound, with moderate edema of both lower limbs, chest tightness and shortness of breath, and could not lie flat, accompanied by palpitations, cough, a small amount of sputum, no nasal congestion and runny nose, no dizziness and headache, dry mouth and bitter mouth, poor appetite, poor sleep, normal bowel movements, pale and dark tongue, white and greasy fur, and a stringy and slippery pulse. Check the heart color Doppler ultrasound: left ventricular wall echo changes, indicating excessive myocardial trabeculation; four-leaf aortic valve and a small amount of regurgitation; left ventricular enlargement. Diagnosed as congenital palpitation and incomplete compactness, the Chinese medicine granules of Example 5 were used, one dose per day, taken twice a day, and followed up after 2 months of treatment. The patient's symptoms improved, chest tightness and shortness of breath improved compared with before, occasional palpitations, no cough and sputum, no edema of both lower limbs, and re-examination of the heart color Doppler ultrasound showed: left ventricular diastolic function decreased, aortic valve degeneration and a small amount of regurgitation.

[0092] It can be seen from the above typical cases that the Chinese medicine composition of the present invention has a significant effect on improving patients with excessive myocardial trabeculation after treatment, and cardiac color Doppler ultrasound shows that excessive myocardial trabeculation disappears after treatment.

[0093] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating excessive myocardial trabeculation, characterized in that: The invention is prepared from the following Chinese medicinal materials in parts by weight: 5-10 parts of Uncaria rhynchophylla, 8-12 parts of Sarcandra chinensis, 12-20 parts of Radix Catnip, 1-6 parts of Sanguisorba officinalis, 3-8 parts of frankincense, 10-15 parts of Trichosanthes root, 3-8 parts of Bupleurum chinense, 5-10 parts of Rhubarb extract, 5-10 parts of Inula japonica, 3-8 parts of Polygala tenuifolia and 5-10 parts of Citrus aurantium.

2. A Chinese medicine composition for treating excessive myocardial trabeculation according to claim 1, characterized in that: Made from the following Chinese medicinal materials in parts by weight: 10 parts of Uncaria rhynchophylla, 12 parts of Sarcandra scabra, 20 parts of Herba Lycopodii, 6 parts of Sanguisorba officinalis, 8 parts of Olibanum, 15 parts of Root of Trichosanthes, 8 parts of Radix Bupleuri, 10 parts of Rheum officinale, 10 parts of Inula flower, 8 parts of Polygala tenuifolia, 10 parts of Citrus aurantium; or, Uncaria rhynchophylla 8 parts, Sarcandra scabra 10 parts, Herba Lycopodii 15 parts, Sanguisorba officinalis 2 parts, Olibanum 6 parts, Root of Trichosanthes kirilowii 12 parts, Radix Bupleuri 6 parts, Rheum officinale 8 parts, Flos Inulae 7 parts, Radix Polygalae 6 parts, Pilosulae citri reticulatae 8 parts; or, Uncaria rhynchophylla 6 parts, Sarcandra scabra 9 parts, Herba Lycopodii 13 parts, Sanguisorba officinalis 1 part, Olibanum 5 parts, Root of Trichosanthes kirilowii 10 parts, Radix Bupleuri 5 parts, Rheum officinale 6 parts, Flos Inulae 6 parts, Tenuifolia tenuifolia 5 parts, Pilosula citri reticulatae 7 parts; or, Uncaria rhynchophylla 7 parts, Sarcandra scabra 11 parts, Herba Lycopodii 18 parts, Sanguisorba officinalis 2 parts, Olibanum 7 parts, Root of Trichosanthes kirilowii 13 parts, Radix Bupleuri 7 parts, Rheum officinale 9 parts, Flos Inulae 8 parts, Radix Polygalae 7 parts, Pilosulae citri reticulatae 9 parts; or, Uncaria rhynchophylla 5 parts, Sarcandra scabra 8 parts, Herba Lycopodii 12 parts, Sanguisorba officinalis 1 part, Olibanum 3 parts, Root of Trichosanthes kirilowii 10 parts, Radix Bupleuri 3 parts, Rheum officinale 5 parts, Flos Inulae 5 parts, Radix Polygalae 3 parts, Pilosulae citri reticulatae 5 parts; or, 9 parts of Uncaria rhynchophylla, 10 parts of Sarcandra scabra, 16 parts of Herba Lycopodii, 3 parts of Sanguisorba officinalis, 5 parts of Olibanum, 14 parts of Radix Trichosanthis, 6 parts of Radix Bupleuri, 7 parts of Radix Rhei, 6 parts of Flos Inulae, 6 parts of Radix Polygalae, 8 parts of Pilosulae Citrus.

3. A Chinese medicine composition for treating excessive myocardial trabeculation according to claim 1 or 2, characterized in that: The Chinese medicine composition is Chinese medicine granules or decoction.

4. A Chinese medicine composition for treating excessive myocardial trabeculation according to claim 3, characterized in that: The preparation method of the Chinese medicine granules is as follows: after cleaning and drying the medicinal materials, the medicinal materials are chopped, put into a casserole for decoction, filtered, and the filtrate is harvested, the filtrate is concentrated into an extract, and the extract is mixed with a flavoring agent and an excipient and then granulated; the excipient is dextrin or starch; The preparation method of the decoction is as follows: after cleaning, drying and chopping the medicinal materials, soaking the processed raw materials in water for 30-60 minutes, boiling them with high fire, decocting them for the first time at 80-100° C. for 10-15 minutes, pouring out 1 / 3-1 / 2 of the medicinal liquid; then adding water to the original volume, decocting them for the second time for 10-15 minutes, the decoction temperature range is 60-80° C., then pouring out all the medicinal liquid, mixing the two medicinal liquids to obtain the decoction.

5. A Chinese medicine composition for treating excessive myocardial trabeculation according to claim 4, characterized in that: In the preparation process of the decoction, the amount of water added during decoction is enough to cover all the Chinese medicinal materials by 3-5 cm; specifically, the medicinal materials are first fully absorbed with water and then put into the casserole, and water is added until all the Chinese medicinal materials are covered by 3-5 cm.