Traditional Chinese medicine composition and traditional Chinese medicine preparation for improving sleep quality as well as preparation method and application of traditional Chinese medicine composition and traditional Chinese medicine preparation

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for improving sleep quality, a traditional Chinese medicine preparation and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from spina date seeds, rhizoma anemarrhenae, poria with hostwood, honey-fried licorice roots, glossy privet fruits and eclipta, and can further comprise platycladi seeds, polygala tenuifolia, schisandra chinensis and the like. The traditional Chinese medicine composition can be prepared into decoction, granules, pills, capsules or oral liquid, and is suitable for improving the sleep quality. The preparation method comprises the steps of raw material weighing, crushing, extraction, concentration, preparation forming and the like. The traditional Chinese medicine preparation disclosed by the invention is reasonable in compatibility and standard in preparation process, has the effects of mildly calming, soothing the nerves, helping sleep and improving the sleep structure, and has no obvious adverse reaction in long-term application. The invention is suitable for clinical popularization and can be widely applied to the pharmaceutical industry.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for improving sleep quality, a traditional Chinese medicine preparation, and a preparation method and application thereof. Technical Background

[0002] The incidence of insomnia in my country is increasing year by year. People spend one-third of their lives sleeping, and good sleep quality is one of the indicators of health. Long-term insomnia has a great impact on the patient's quality of life, physical, mental and mental state.

[0003] Currently, there are two main aspects of modern medicine for the treatment of insomnia, namely drug treatment and non-drug treatment.

[0004] Drug treatment mainly involves the use of hypnotic drugs, which are suitable for short-term treatment. Such drugs have the characteristics of fast hypnotic effect and obvious curative effect. However, side effects are also very common, including hangover reaction of varying degrees, memory impairment, dependence, and rebound insomnia after drug withdrawal.

[0005] Non-drug treatments mainly include cognitive therapy, hyperbaric oxygen therapy, sleep restriction, transcranial magnetic stimulation therapy, and sleep hygiene education. Non-drug treatments have the advantages of obvious efficacy and no side effects. In particular, cognitive therapy is recommended by the European Association of Sleep Physicians as a first-line treatment for chronic insomnia. However, this type of therapy has disadvantages such as long onset time, low patient compliance, and lack of professional clinicians to implement it, so it has not been widely used in the treatment of insomnia.

[0006] Modern medicine has not yet found an ideal treatment method for both drug treatment and non-drug treatment, which means that many chronic insomnia patients cannot properly solve their long-term insomnia problems. In view of the many toxic side effects of insomnia drugs, many insomnia patients in China are resistant or afraid of taking Western medicine to treat insomnia, especially the elderly. Long-term oral use of sleeping pills can cause the risk of sudden collapse and fractures. Therefore, it is of great significance to develop an efficient and safe Chinese medicine composition for improving sleep. Summary of the invention

[0007] The purpose of the present invention is to overcome the above-mentioned problems existing in the current methods of improving sleep quality, and to provide a Chinese medicine composition, a Chinese medicine preparation and a preparation method and application thereof for improving sleep quality.

[0008] To achieve the above object, the present invention is implemented through the following technical solutions:

[0009] The present invention provides a Chinese medicine composition for improving sleep quality, characterized in that the medicine composition comprises: Ziziphus jujuba seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae Preparata, Fructus Ligustri Lucidi and Ecliptae;

[0010] The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

[0011] Furthermore, the content of Ziziphus jujuba seeds is 12 parts by weight, the content of Anemarrhena asphodeloides is 10 parts by weight, the content of Poria cocos is 10 parts by weight, the content of Glycyrrhiza uralensis is 8 parts by weight, the content of Ligustrum lucidum is 10 parts by weight, and the content of Eclipta prostrata is 10 parts by weight.

[0012] The present invention provides a method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that the medicine combination comprises: a Chinese medicine decoction prepared from Chinese jujube seeds, rhizoma anemarrhenae, rhizoma poriae, licorice root, fructus ligustri lucidi and herba ecliptae, and the method comprises the following steps:

[0013] (1) After accurate weighing, add Ziziphus jujuba seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid;

[0014] (2) Add water again, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid;

[0015] (3) Mix the two liquids to obtain a Chinese medicine decoction.

[0016] The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

[0017] The present invention provides a method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that the medicine combination comprises: granules prepared from spiny jujube seeds, rhizoma anemarrhenae, rhizoma poriae, licorice root, fructus ligustri lucidi and herba ecliptae, and the method comprises the following steps:

[0018] (1) After accurate weighing, crush the seeds of Ziziphus jujuba, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae Herba into powder and put them into a decoction container;

[0019] (2) Add clean water and soak for 2 hours, boil for a certain period of time and pour out the liquid, repeat the decoction twice, and collect the liquid obtained three times;

[0020] (3) collecting the liquid, centrifuging it, and concentrating it at low temperature, and integrating the concentrate with the auxiliary materials to obtain granules;

[0021] The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

[0022] The present invention provides a method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that the medicine combination comprises: pills made from spiny jujube seeds, rhizoma anemarrhenae, rhizoma poriae, licorice root, fructus ligustri lucidi and ecliptae, and the method comprises the following steps:

[0023] (1) After accurate weighing, crush the Chinese date seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae into fine powder;

[0024] (2) sieving, mixing, adding honey or other adhesives, rolling into pills, and drying to obtain pills;

[0025] The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

[0026] The present invention also provides a traditional Chinese medicine preparation prepared by the preparation method.

[0027] The present invention also provides the use of the above-mentioned Chinese medicine composition, or the Chinese medicine preparation prepared by the above-mentioned preparation method in improving sleep quality.

[0028] The efficacy of each component in the formula of the present invention is described as follows:

[0029] Ziziphus jujuba seed: the seed of the plant Ziziphus jujuba of the Rhamnaceae family. It is sweet and neutral in nature. Functions and indications: nourish the liver, calm the mind, soothe the nerves, and astringe sweat. "Bie Lu": It is used to treat restlessness and insomnia, pain above and below the navel, prolonged blood circulation, sweating and thirst, tonify the middle, benefit the liver qi, strengthen the tendons and bones, help the yin qi, and make people fat and healthy. "Ben Cao Hui Yan": It can astringe qi and soothe the mind, nourish the tendons and marrow, and harmonize the stomach and spleen.

[0030] Anemarrhena: It is the dried rhizome of the monocotyledonous plant Anemarrhena of the Liliaceae family. It tastes bitter and is cold in nature. Functions and indications: Clearing away heat and purging fire, nourishing yin and moistening dryness.

[0031] Fu Shen: It is the part of the sclerotium of the plant Poria cocos of the Polyporaceae family with pine roots. It tastes sweet and has a mild nature. Functions and indications: dispelling dampness, strengthening the spleen, and calming the mind.

[0032] Roasted Licorice: It is a plant of the Leguminosae family, licorice, stir-fried with honey, and has a sweet taste and a neutral nature. Functions and indications: tonifying the middle and replenishing qi, moistening the lungs and relieving cough, relieving acute pain.

[0033] Ligustrum lucidum: Ligustrum lucidum is the dried mature fruit of Ligustrum lucidum of Oleaceae, sweet, bitter and cool in nature. Functions and indications: nourishes liver and kidney, improves eyesight and blackens hair, and clears away heat.

[0034] Eclipta prostrata: It is the dried aerial part of the plant Channa sphaerocephala of the Asteraceae family. It tastes sweet and sour, and is cold in nature. Functions and indications: nourishes the liver and kidneys, cools blood and stops bleeding.

[0035] Through many years of clinical efficacy observation, the Chinese medicine preparation of the present invention can significantly improve sleep quality. DETAILED DESCRIPTION

[0036] The technical solutions in the embodiments of the present invention are described clearly and completely below. It is obvious that the described embodiments are only a part of the present invention, rather than all embodiments.

[0037] The relevant specific embodiments of the present invention are as follows:

[0038] Example 1

[0039] A traditional Chinese medicine preparation for improving sleep quality has the following mass ratios: 12 parts by weight of Semen Ziziphi Spinosae, 10 parts by weight of Rhizoma Anemarrhenae, 10 parts by weight of Radix Poriae, 8 parts by weight of Radix Glycyrrhizae Preparata, 10 parts by weight of Fructus Ligustri Lucidi, and 10 parts by weight of Eclipta Prostrata.

[0040] preparation:

[0041] (1) After accurate weighing, add Ziziphus jujuba seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid;

[0042] (2) Add water again, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid;

[0043] (3) Mix the two liquids to obtain a Chinese medicine decoction.

[0044] Example 2

[0045] A traditional Chinese medicine preparation for improving sleep quality has the following mass ratios: 12 parts by weight of Semen Ziziphi Spinosae, 10 parts by weight of Rhizoma Anemarrhenae, 10 parts by weight of Radix Poriae, 8 parts by weight of Radix Glycyrrhizae Preparata, 10 parts by weight of Fructus Ligustri Lucidi, and 10 parts by weight of Eclipta Prostrata.

[0046] preparation:

[0047] (1) After accurate weighing, crush the seeds of Ziziphus jujuba, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae Herba into powder and put them into a decoction container;

[0048] (2) Add clean water and soak for 2 hours, boil for a certain period of time and pour out the liquid, repeat the decoction twice, and collect the liquid obtained three times;

[0049] (3) After collecting the liquid and centrifuging it, it is concentrated at low temperature, and the concentrate is integrated with the auxiliary materials to obtain granules.

[0050] Example 3

[0051] A traditional Chinese medicine preparation for improving sleep quality has the following mass ratios: 12 parts by weight of Semen Ziziphi Spinosae, 10 parts by weight of Rhizoma Anemarrhenae, 10 parts by weight of Radix Poriae, 8 parts by weight of Radix Glycyrrhizae Preparata, 10 parts by weight of Fructus Ligustri Lucidi, and 10 parts by weight of Eclipta Prostrata.

[0052] preparation:

[0053] (1) After accurate weighing, crush the Chinese date seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae into fine powder;

[0054] (2) Sieve, mix well, add honey or other adhesives, roll into pills, and dry to obtain pills.

[0055] Typical Cases

[0056] Case 1: Qi, male, 48 years old, main complaint: repeated insomnia for 1 year, aggravated for 7 days. The patient sleeps more than 3-4 hours every night, has difficulty falling asleep, is sensitive to external stimuli, has strict requirements on sleeping conditions, has difficulty falling asleep with a little sound and light stimulation, lacks sleep depth, is easily awakened, has difficulty falling asleep after waking up, is upset, daytime fatigue, weakness, palpitations, diet is OK, stool is normal, small yellow, red tongue, thin yellow fur, and fine pulse. Diagnosis: insomnia. 7 pairs of relevant Chinese medicine decoctions in Example 1 are given, and they are taken orally half an hour after meals in the morning and evening. After a week, the patient's sleep quality has improved significantly, and he can tolerate external stimuli and sleep about 5 hours every night. After 14 days of follow-up treatment with the previous prescription, the patient's sleep quality has further improved, and he can fall asleep in bed for about 20 minutes, almost without awakening, and has no palpitations and upset symptoms. Continue to consolidate the therapeutic effect with 14 pairs of this prescription, and no follow-up. After half a year, the follow-up patient's insomnia has returned to normal, and he is energetic during the day.

Claims

1. A Chinese medicine composition for improving sleep quality, characterized in that: The drug combination includes: Ziziphus jujuba seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae Preparata, Fructus Ligustri Lucidi, Eclipta prostrata; The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

2. The Chinese medicine composition according to claim 1, characterized in that: The content of Semen Ziziphi Spinosae is 12 parts by weight, the content of Rhizoma Anemarrhenae is 10 parts by weight, the content of Radix Poriae Root is 10 parts by weight, the content of Radix Glycyrrhizae Preparata is 8 parts by weight, the content of Fructus Ligustri Lucidi is 10 parts by weight, and the content of Eclipta Prostrata is 10 parts by weight.

3. A method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that: The drug combination comprises: a Chinese medicinal decoction prepared from spiny jujube seeds, rhizoma anemarrhenae, root of poria, roasted liquorice root, fruit of glossy privet and herba ecliptae; the method comprises the following steps: (1) After accurate weighing, add Ziziphus jujuba seeds, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid; (2) Add water again, bring to a boil over high heat, then simmer for 30 minutes over low heat, and pour out the liquid; (3) mixing the two liquids to obtain a Chinese medicine decoction; The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

4. A method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that: The drug combination comprises: granules prepared from spiny jujube seeds, rhizoma anemarrhenae, root of poria, roasted liquorice root, fruit of glossy privet and herba ecliptae. The method comprises the following steps: (1) After accurate weighing, crush the seeds of Ziziphus jujuba, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae Herba into powder and put them into a decoction container; (2) Add clean water and soak for 2 hours, boil for a certain period of time and pour out the liquid, repeat the decoction twice, and collect the liquid obtained three times; (3) collecting the liquid, centrifuging it, and concentrating it at low temperature, and integrating the concentrate with the auxiliary materials to obtain granules; The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

5. A method for preparing a Chinese medicine preparation for improving sleep quality, characterized in that: The drug combination comprises: pills prepared from spiny jujube seeds, rhizoma anemarrhenae, root of poria, roasted liquorice root, fruit of glossy privet and herba ecliptae. The method comprises the following steps: (1) After accurate weighing, crush the seeds of Ziziphus jujuba, Rhizoma Anemarrhenae, Radix Poriae, Radix Glycyrrhizae, Fructus Ligustri Lucidi, and Ecliptae into fine powder; (2) sieving, mixing, adding honey or other adhesives, rolling into pills, and drying to obtain pills; The raw material composition is 10-15 parts by weight of Ziziphus jujuba seeds, 6-12 parts by weight of Rhizoma Anemarrhenae, 10-15 parts by weight of Poria, 2-10 parts by weight of Radix Glycyrrhizae Preparata, 6-12 parts by weight of Fructus Ligustri Lucidi and 6-12 parts by weight of Eclipta prostrata.

6. A Chinese medicine preparation obtained by the preparation method according to any one of claims 3 to 5.

7. Use of the Chinese medicine composition according to claim 1 or 2, or the Chinese medicine preparation prepared by the preparation method according to any one of claims 3 to 5.