Traditional Chinese medicine preparation for treating diabetes and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine preparation for treating diabetes mellitus. The traditional Chinese medicine preparation is a medicament prepared from the following raw medicinal materials in parts by weight: 52 medicines such as astragalus membranaceus, rhizoma polygonati, Chinese yam, pulp of dogwood fruit and the like. The preparation method 1 comprises the following steps: (1) preparing the raw material medicines into a water extracting solution, (2) preparing the water extracting solution into oral liquid, (3) drying, crushing and sieving the water extracting solution to obtain medicine extracting powder, and (4) preparing the medicine extracting powder into tablets, granules, pills, electuary or capsules. The preparation method 2 comprises the following steps: (1) drying the fresh pig pancreas, and grinding into powder; (2) crushing other raw material medicines, and sieving to obtain medicinal powder; (3) uniformly mixing the pig pancreas powder and the medicinal powder, and disinfecting and sterilizing to obtain raw powder; and (4) preparing the raw powder into tablets, granules, pills, electuary or capsules in oral preparations. The medicine is organically combined according to the principle of monarch, minister, assistant and guide, has a synergistic effect, treats both symptoms and root causes, has a better curative effect on diabetes and has an obvious effect on severe diabetes. The raw material medicines adopted by the invention are common traditional Chinese medicines, are low in preparation cost and basically have no toxic or side effect.

Description

Technical Field

[0001] The invention relates to a medicine prepared from traditional Chinese medicine and a preparation method thereof, in particular to a traditional Chinese medicine preparation for treating diabetes and a preparation method thereof. Background Art

[0002] Diabetes is a metabolic disease characterized by high blood sugar caused by multiple factors such as genetics, environment and immune system. It is mainly caused by disordered insulin secretion or defective insulin action in the body. With the improvement of people's living standards and the gradual change of lifestyle and work style, the number of diabetes patients in my country has also increased significantly. Diabetes is a syndrome with persistent high blood sugar as its basic feature. It is mainly divided into insulin-dependent type (type 1) and insulin-independent type (type 2), and about 90% of clinical cases are type 2. Its basic physiological and pathological features are relative or absolute lack of insulin in the body, which causes metabolic disorders of sugar, protein, fat, water and electrolytes, characterized by high blood sugar, urine sugar, impaired glucose tolerance and abnormal insulin release test. Symptoms include polydipsia, polyphagia, polyuria, thirst, hunger, weight loss, fatigue and weakness. It is often complicated or accompanied by acute infection, arteriosclerosis, renal and retinal microvascular lesions and neuropathy. Since there is no drug to cure diabetes, especially the complications of diabetes cannot be effectively controlled, the world is exploring new treatment methods from different ways. Traditional Chinese medicine believes that diabetes is a "thirst" disease. Symptoms of diabetes include polydipsia, polyphagia, polyuria, weight loss, or turbid or sweet urine. The name of diabetes was first mentioned in the Neijing. Summary of the invention

[0003] The purpose of the present invention is to provide a new Chinese medicine preparation that can effectively treat diabetes, specifically a Chinese medicine preparation for treating diabetes and a technical solution for its preparation method.

[0004] The technical scheme of the present invention is a Chinese medicine preparation for treating diabetes, which is a medicine prepared from the following raw medicinal materials in proportion by weight: 6-60 parts of Astragalus, 6-30 parts of Polygonatum, 6-60 parts of Dioscorea, 6-30 parts of Cornus, 6-60 parts of Salvia, 6-60 parts of Pueraria, 6-60 parts of Gallus Gallus, 6-60 parts of Lycium, 6-30 parts of Perilla, 6-60 parts of Pollen, 6-90 parts of Gypsum, 6-90 parts of Anemarrhena, 6-90 parts of Ophiopogon, 6-90 parts of Radix Rehmanniae, 6-60 parts of Burdock, 6-60 parts of Coptis, 6-30 parts of Phellodendron, 6-30 parts of Scrophularia, 6-60 parts of White Peony, 6-30 parts of Schisandra, 6-60 parts of American Ginseng, 6-60 parts of Cortex Lycii, 6-60 parts of Morus Albizia, 6-60 parts of Polygonatum, -60, Achyranthes bidentata 6-60, Cortex Moutan 6-60, Fructus Trichosanthis 6-60, Rhubarb 6-60, Poria 6-30, Leech 6-30, Dendrobium 6-60, Tribulus terrestris 6-30, Kochia scoparia 6-30, Spica Prunellae 6-30, Pheretima 6-30, Plum ebony 6-30, Poria powder 6-120, Fructus Ligustri Lucidi 6-90, Bitter Melon 6-90, Celery Seed 6-60, Coix Seed 6-60, Millettia Spatholobi 6-60, Flos Lonicerae 6-30, Taraxacum mongolica 6-30, Hawthorn 6-30, Semen Cassiae 6-30, Polygonum multiflorum 6-60, Lilium 6-30, Pseudostellariae Pseudostellariae 6-30, Atractylodes 6-30, Polygonum cuspidatum 6-50, Silkworm Cooter 6-30.

[0005] The medicine is oral liquid, powder, capsule, granule, tablet or pill.

[0006] A method for preparing a Chinese medicine preparation for treating diabetes, comprising the following steps: (1) preparing the raw material medicine of claim 1 into a water extract having a water content of 10% by conventional methods; (2) preparing an oral liquid by using the water extract prepared in step (1) by conventional methods; (3) drying, crushing, and passing the water extract obtained in step (1) through a sieve of at least 200 meshes, and taking the sieve residue as a drug extract powder; and (4) preparing tablets, pills, granules or capsules by using the drug extract powder prepared in step (3) by conventional methods.

[0007] A method for preparing a Chinese medicine preparation for treating diabetes, comprising the following steps: (1) drying fresh pig pancreas and grinding it into powder; (2) sieving the dust from other raw materials of claim 1, crushing them, passing them through a sieve of at least 200 meshes, and taking the sieved material as medicine powder; (3) uniformly mixing the pig pancreas powder obtained in steps (1) and (2) with the medicine powder, and sterilizing them according to conventional methods to obtain a raw powder powder; and (4) preparing tablets, pills, granules or capsules for oral administration using the raw powder powder obtained in step (3) according to conventional methods.

[0008] According to traditional Chinese medicine, diabetes is mostly caused by uncontrolled diet, excessive consumption of fatty and sweet food, spicy and dry food, excessive emotions, anger and depression, or mental fatigue, excessive sexual intercourse, excessive desire, genetic inheritance, infection with evil toxins, and fever, which damage the lungs, stomach, and kidneys, internal heat, loss of yin essence, abnormal qi transformation, and abnormal distribution of body fluids, which overflow into the blood vessels or go directly downward. The disease can be divided into upper, middle, and lower "three consumptions", and the differences are lung dryness, stomach heat, and kidney deficiency. Lung dryness is the main cause, and those who drink a lot are "upper consumption"; stomach heat is the main cause, and those who eat a lot are "middle consumption"; kidney deficiency is the main cause, and those who urinate a lot are "lower consumption". The disease is mainly characterized by excess at the beginning, both deficiency and excess are seen in the middle stage, and deficiency is the main cause in the late stage. Diabetes is generally divided into lung dryness and fluid deficiency syndrome, stomach heat and fluid damage syndrome, kidney yin deficiency syndrome, and yin and yang deficiency syndrome according to traditional Chinese medicine syndrome differentiation and treatment. The disorder of transportation and transformation, the loss of normal distribution of body fluid essence, overflow of blood vessels, or direct discharge. The present invention is mainly based on the principle of traditional Chinese medicine to differentiate and treat, gathers the strengths of many doctors, widely collects wonderful medicines and prescriptions from various ethnic regions in Yunnan, based on the understanding and treatment principles of the pathogenesis of diabetes in traditional Chinese medicine, and refers to the achievements of ancient and modern pharmacological research, screens natural Chinese medicines that can activate blood circulation and remove blood stasis, soothe the liver and extinguish wind, and nourish blood and open the orifices, formulates according to the theory of traditional Chinese medicine, extracts the essence, and is summarized through the clinical practice of long-term diagnosis and treatment of cases.

[0009] The prescription of the present invention is analyzed as follows: American ginseng, adenophora, astragalus, coix seed, yam, pollen, kudzu root, chicken gizzard lining and pseudostellaria in the prescription can nourish qi, yin and produce body fluid; gypsum, rhubarb, raw rehmannia and ophiopogon can nourish yin and clear heat, and are all monarch medicines; burdock fruit, coptis chinensis, phellodendron, mulberry leaf, rhubarb, bitter melon, honeysuckle and clear heat are ministers; wolfberry, schisandra chinensis, Achyranthes bidentata, Ligustrum lucidum, cornus fruit and white peony root can nourish liver and kidney as adjuvants; Achyranthes bidentata, salvia miltiorrhiza, moutan bark, hawthorn and earthworm can promote blood circulation and remove blood stasis as messengers; all the medicines can work together to relieve thirst for a long time, deficiency of both qi and yin, deficiency of both lung, spleen and kidney, dry mouth and tongue, thirst and frequent urination, inability of qi to distribute body fluid, inability to retain body fluid, damage to body fluid and dryness, drowsiness and fatigue, and weak and powerless pulse.

[0010] The dialectical guide of the present invention: replenishing qi and nourishing yin, clearing away heat, promoting the production of body fluid and quenching thirst, removing blood stasis and consolidating. It is used for deficiency of both qi and yin, deficiency of both lung, spleen and kidney, long-term illness will lead to blood stasis, qi cannot distribute body fluid, yin damage and qi consumption, inability to consolidate, body fluid damage and dryness, drowsiness and fatigue, weak pulse and weakness. This disease lasts for a long time, qi and yin are damaged, yin deficiency and dryness and heat will occur, multiple syndromes will occur, yin body fluid is extremely depleted, and finally coma may be seen due to yin exhaustion and yang death. Lungs lose moisture, and tuberculosis may occur over time. Kidney yin is deficient, liver loses nourishment, liver and kidney essence and blood cannot carry ears and eyes, then cataracts, night blindness, deafness may occur. Dry heat and internal yin are burned, collaterals are blocked, and toxins are accumulated to form pus, which is caused by sores, furuncles, and carbuncles. Yin damage and yang, spleen and kidney failure, water retention, flooding the skin, then edema. Long-term illness and blood stasis may be complicated by severe diseases such as stroke, hemiplegia, chest pain and heart pain. If the prognosis is poor, it may lead to death.

[0011] Pharmacological action of the present invention: Diabetes is a complex disease with complex etiology, and the heterogeneity of etiology leads to the diversity of clinical manifestations. Western medicine believes that tension or psychological emotional factors can cause endocrine axis immune network secretion disorders, and anxiety reduces blood insulin content, which can induce diabetes. Dietary control leading to obesity and insulin resistance can induce diabetes. Increased secretion of adrenaline and adrenal cortex hormones in the body resists insulin, promotes gluconeogenesis and increases blood sugar to cause diabetes. Studies have confirmed that hyperlipidemia, abnormal blood flow, slow blood flow, and tissue hypoxia are both the pathogenic factors of diabetes and its pathological products, and are the causes of complications caused by aggravation of the disease. Insulin is the driving force for human energy utilization and the starting link for glycogen decomposition and synthesis. Insulin deficiency can cause sugar to be unusable. Increased decomposition of fat and protein, accumulation of lactic acid, and production of ketone bodies lead to clinical occurrence. Astragalus promotes insulin secretion to facilitate the utilization and metabolism of various nutrients. Blood stasis and the high viscosity and high coagulation state of blood are closely related to the formation of diabetes and microvascular complications. Activating blood circulation and removing blood stasis are important therapeutic principles for preventing and treating various complications of diabetes. Blood sugar accumulation in the body can cause sugar poisoning, and fat accumulation can cause hyperlipidemia. Astragalus is one of the traditional Chinese medicines that increase insulin secretion. Astragalus promotes the secretion of insulin by pancreatic β cells in diabetes. Astragalus has a two-way regulation of immune function. The main functions of Astragalus are vasodilation, lowering blood pressure, increasing renal blood flow, reducing platelet adhesion rate, improving microcirculation, resisting hypoxia, regulating immunity, and scavenging free radicals. Astragalus has a protective effect on the kidneys. Astragalus can reduce permeability proteinuria and has a reducing and eliminating effect on renal proteinuria. Astragalus can significantly reduce the levels of platelet α granule membrane protein, thromboxane B2 and endothelin in patients with diabetic nephropathy, and has a protective effect on patients with early diabetic nephropathy. American ginseng, astragalus, coix seed, yam, and wolfberry are rich in plant polysaccharides, water-soluble cellulose, multiple amino acids, and essential trace elements such as zinc, chromium, and selenium. Chromium and zinc deficiency in the human body can easily lead to decreased glucose tolerance and diabetes. These trace elements can enhance and improve insulin sensitivity, promote insulin secretion, increase biological activity, promote sugar metabolism, reduce fat, protein decomposition, improve microcirculation, and promote the gradual reduction of blood sugar and blood lipids. Cornus can promote insulin secretion, pollen can reduce blood sugar activity, and gypsum, Anemarrhena, and American ginseng can reduce blood sugar more significantly. Pueraria root, Salvia miltiorrhiza, and Achyranthes bidentata all have the effect of lowering blood pressure and blood sugar. This prescription can control complications and improve their symptoms until a significant effect is achieved, so that the quality of life can be improved, insulin resistance can be improved, and insulin secretion and tissue sensitivity to insulin can be increased.

[0012] The medicine of the present invention is organically combined according to the principle of monarch, minister, assistant and envoy, synergistically, treating both the symptoms and the root causes, having a good curative effect on diabetes, and having an obvious effect on severe diabetes. The raw material medicine used in the present invention is a commonly used common Chinese medicine, with low production cost and basically no toxic side effects.

[0013] The oral liquid of the present invention is taken orally 3 times a day, 5-100 ml each time, or one of tablets, granules, pills, powders, capsules, granules, etc. is selected, 3-10 grams each time, 3 times a day, various dosage forms can be used alternately, and the extraction powder and various dosage forms prepared therefrom are the same as the raw powder powder and various dosage forms prepared therefrom. 20 days of treatment is a course of treatment, 1-3 courses of treatment for mild cases, and 3-5 courses of treatment for severe cases. The combined treatment with western medicine has a better effect.

[0014] Taboos: No sugary foods, fatty foods, fried and grilled foods. No smoking or drinking.

[0015] Note: Diet control, physical exercise, moderate sexual life. Check blood sugar regularly. Use under the guidance of a physician.

[0016] Clinical trial data of the present invention:

[0017] A total of 100 cases of diabetes were followed up and treated by the present invention, including 57 males and 43 females, aged 40-80 years old, and 1-20 years after the onset of the disease. Patient symptoms include thirst and drinking, good digestion and hunger, itching with ants, numbness of limbs, cold extremities, pain or tingling in limbs, fatigue, spontaneous sweating, fever in the five hearts, constipation, enlarged tongue, dark purple tongue or ecchymosis, and fine or astringent pulse. Fasting blood sugar ≥7.8mmol / L, blood sugar ≥11.1mmol / L 2 hours after meal. Among them, there were 9 patients with type 1 diabetes and 91 patients with type 2 diabetes.

[0018] Treatment method: Oral liquid 10-20ml each time, 3 times a day, granules, powders, capsules, granules, pills, etc. 3-10g each time, 3 times a day. One course of treatment is 10 days. Usually 1-3 courses of treatment, 4-5 courses of treatment for severe cases.

[0019] After 1-3 courses of treatment, 34 patients had significant improvement in their clinical symptoms, with a total significant improvement rate of 34%. 57 patients had partial improvement in their clinical symptoms, with a total improvement rate of 57%. 9 patients had no improvement in their clinical symptoms, with a total ineffective rate of 9%. No obvious adverse drug reactions or side effects were observed during the treatment, and no discomfort in the liver, kidney, lung, spleen, or stomach was found. DETAILED DESCRIPTION

[0020] Table 1

[0021]

[0022] 1. A method for preparing a Chinese medicine preparation for treating diabetes. The raw materials are prepared according to Table 1. All the medicines are dry products. The specific preparation method is composed of the following steps:

[0023] (1) The raw materials in Table 1 are prepared into a water extract having a water content of 10% by conventional methods.

[0024] (2) preparing an oral solution using the water extract obtained in step (1) according to a conventional method,

[0025] (3) drying, crushing, and passing the aqueous extract obtained in step (1) through a sieve of at least 200 meshes, and taking the sieve residue as a drug extract powder;

[0026] (4) The drug extract powder prepared in step (3) is prepared into tablets, pills, granules or capsules for oral administration according to conventional methods. Pills and granules contain 3-5 grams of drug powder per bag; tablets contain 0.2-0.5 grams of drug powder per tablet; capsules contain 0.2-0.5 grams of drug powder per capsule; powders contain 3-5 grams per bag.

[0027] 2. A method for preparing a Chinese medicine preparation for treating diabetes, wherein the raw materials are prepared according to Table 1, the pig pancreas is fresh, and the other medicines are dry products, and the preparation is made by the following steps:

[0028] (1) Dry the fresh pig pancreas and grind it into powder.

[0029] (2) The raw materials except fresh porcine pancreas listed in Table 1 are sieved to remove dust, crushed, and passed through a sieve of at least 200 meshes. The sieved material is taken.

[0030] (3) The pig pancreas powder obtained in steps (1) and (2) and the drug powder are mixed evenly, and sterilized by conventional methods such as high temperature and ultraviolet light to obtain a raw powder powder.

[0031] (4) The raw powder prepared in step (3) is prepared into tablets, granules, pills, granules or capsules for oral administration according to conventional methods. For pills and granules, each bag contains 3-5 grams of drug powder; for tablets, each tablet contains 0.2-0.5 grams of drug powder; for capsules, each granule contains 0.2-0.5 grams of drug powder; for powders, each bag contains 3-5 grams of drug powder.

Claims

1. A Chinese medicine preparation for treating diabetes, characterized in that It is a medicine made from raw medicinal materials in the following weight proportions:

2. A Chinese medicine preparation for treating diabetes according to claim 1, characterized in that: The medicine is oral liquid, powder, capsule, granule, tablet or pill.

3. The method for preparing a Chinese medicine preparation for treating diabetes according to claim 1, characterized in that It consists of the following steps: (1) The raw material drug of claim 1 is prepared into a water extract having a water content of 10% by conventional methods, (2) preparing an oral solution using the water extract obtained in step (1) according to a conventional method, (3) drying, crushing, and passing the aqueous extract obtained in step (1) through a sieve of at least 200 meshes, and taking the sieve residue as a drug extract powder; (4) The drug extract powder prepared in step (3) is prepared into tablets, pills, granules or capsules according to conventional methods.

4. The method for preparing a Chinese medicine preparation for treating diabetes according to claim 1, characterized in that: Made by the following steps: (1) Dry the fresh pig pancreas and grind it into powder. (2) The other raw materials described in claim 1 are sieved to remove dust, crushed, and passed through a sieve of at least 200 meshes, and the sieved material is taken as the drug powder. (3) The pig pancreas powder and the drug powder obtained in steps (1) and (2) are mixed evenly, and sterilized by conventional methods to obtain a raw powder powder. (4) The raw powder prepared in step (3) is prepared into tablets, pills, granules or capsules according to conventional methods.

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