Traditional Chinese medicine composition, preparation and medicine for treating phlegm-dampness stasis type obesity

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition, preparation and medicine for treating phlegm-dampness stasis type obesity, and the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of rhizoma alismatis, 20-30 parts of poria cocos and 10-12 parts of polyporus umbellatus. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-12 parts of roasted rhizoma atractylodis macrocephalae, 20-30 parts of coix seeds, 10-12 parts of cassia twigs, 12-15 parts of lotus leaves, 20-30 parts of exocarpium benincasae, 10-12 parts of rhizoma acori graminei, 10-12 parts of haws, 12-15 parts of radix salviae miltiorrhizae, 6-10 parts of radix notoginseng and 3-5 parts of leeches. The traditional Chinese medicine composition for treating the phlegm-dampness stasis type obesity is good in phlegm-dampness stasis type obesity treatment effect and small in side effect, and when the traditional Chinese medicine composition is prepared into a preparation, more stable medicine release is provided, medicine degradation in gastric acid is avoided, and it is ensured that the medicine reaches the effective treatment concentration in the body. The preparation and pharmaceutically acceptable auxiliary materials are used for preparing the medicine, so that the safety of the medicine is improved, and the adverse reaction is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and more specifically to a traditional Chinese medicine composition, preparation and medicine for treating phlegm-dampness and blood stasis type obesity. Background Art

[0002] With the improvement of living standards and unreasonable dietary structure, the number of overweight and obese people has increased year by year, and it is more obvious among middle-aged and elderly patients with cardiovascular and cerebrovascular diseases.

[0003] Studies have shown that obese people have a significantly increased risk of developing type 2 diabetes, cardiovascular disease, hypertension, stroke, and certain cancers, such as breast cancer, colon cancer, and prostate cancer. In addition, obesity may also cause complications such as bone and joint diseases and sleep apnea syndrome, which seriously affect patients' daily lives and health. From a physiological mechanism perspective, obesity is closely related to metabolic syndrome. Metabolic syndrome is a group of metabolic disorders centered on insulin resistance, including hypertension, hyperlipidemia, hyperglycemia, etc. These metabolic disorders further increase patients' risk of chronic diseases. Therefore, low body weight is a protective factor for cardiovascular metabolic diseases. Overweight, obesity, and abdominal obesity are risk factors for cardiovascular metabolic diseases. Overweight, obesity and hyperlipidemia are important risk factors for cardiovascular and cerebrovascular diseases, especially in patients with obesity and hyperlipidemia of phlegm-dampness and blood stasis type. The main manifestations are: obesity, fatigue, dizziness, drowsiness, swollen eyelids, heavy lower limbs or edema; sticky mouth, no desire to drink water, poor appetite, excessive phlegm or inability to cough up; frequent bowel movements per day, unformed bowel movements that disperse with water; pale and fat tongue, slippery or greasy white tongue coating, with teeth marks on the edges; and a soft, slippery and slow pulse.

[0004] In recent years, traditional Chinese medicine has gradually received widespread attention. The core idea of ​​Chinese medicine is prevention first, which coincides with the core principle of preventive medicine in modern medicine, reflecting the core value of Chinese medicine culture. In the face of obesity, a cross-disciplinary disease with blurred boundaries, the holistic concept of Chinese medicine provides a solid theoretical basis for its understanding and diagnosis; and the dialectical treatment of Chinese medicine is the key method for the treatment of obesity. In terms of drug selection, the diversity of Chinese medicine and the exquisiteness of compound compatibility provide a powerful means for the prevention and treatment of obesity.

[0005] As obesity becomes increasingly common, modern medicine has not yet clearly classified obesity. Treatment mainly focuses on the complications caused by obesity, and there is a lack of systematic classification and medication guidance for obesity itself. Common weight loss drugs on the market currently include the following categories: First, appetite suppressants, which reduce food intake by stimulating the central nervous system and increasing satiety, but may cause side effects such as insomnia and anxiety, and should not be used for a long time or at night. Secondly, gastrointestinal lipase inhibitors, which help lose weight by inhibiting the absorption of fat, have relatively small side effects, but may cause indigestion or respiratory infections. Finally, hormone-based weight loss drugs achieve weight loss by accelerating metabolism and fat decomposition, but excessive use may cause symptoms such as arrhythmia, insomnia, and sweating, so they should be used with caution.

[0006] In summary, it is necessary to provide a Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity. Summary of the invention

[0007] In order to solve the above problems, the present invention provides a Chinese medicine composition, preparation and medicine for treating phlegm-dampness and blood stasis type obesity.

[0008] The present invention is achieved through the following technical solutions: A Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity, which is prepared from the following Chinese medicine raw materials by weight: 20-30 portions of Alisma orientalis, 20-30 portions of Poria cocos, 10-12 portions of Polyporus umbellatus, 10-12 portions of stir-fried Atractylodes macrocephala, 20-30 portions of Coix seeds, 10-12 portions of cinnamon twigs, 12-15 portions of lotus leaves, 20-30 portions of wax gourd peel, 10-12 portions of Acorus calamus, 10-12 portions of hawthorn, 12-15 portions of Salvia miltiorrhiza, 6-10 portions of Panax notoginseng, and 3-5 portions of leeches.

[0009] Preferably, it is made from the following Chinese medicinal materials by weight: 25 parts of orientalis, 25 parts of tuckahoe, 11 parts of umbellatus, 11 parts of stir-fried atractylodes, 25 parts of coix seeds, 11 parts of cassia twig, 13 parts of lotus leaves, 25 parts of wax gourd peel, 11 parts of calamus, 11 parts of hawthorn, 13 parts of salvia miltiorrhiza, 8 parts of panax notoginseng, and 4 parts of leech.

[0010] Preferably, the preparation method of the Chinese medicine composition for treating phlegm-dampness stasis type obesity comprises: (1) Mixing the Chinese medicinal materials according to weight to obtain a mixture.

[0011] (2) Add water equivalent to 8 to 10 times the volume of the mixture.

[0012] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 6 to 8 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 6 to 8 times the volume of the residue.

[0013] (4) Repeat step (3) at least once, and combine all the filtrates to obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0014] A preparation prepared from the Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity, wherein the preparation is an oral preparation.

[0015] Preferably, the preparation prepared from the Chinese medicine composition for treating phlegm-dampness stasis type obesity is a decoction.

[0016] A medicine for treating phlegm-dampness and blood stasis type obesity, comprising the preparation and pharmaceutically acceptable excipients.

[0017] Preferably, the drug is made from the preparation and pharmaceutically acceptable excipients.

[0018] Preferably, the pharmaceutically acceptable excipient is one or more of a diluent, a disintegrant, a precipitation inhibitor, a glidant, a binder, a dispersant, a suspending agent, an isotonic agent, a thickener, an emulsifier, a preservative and a stabilizer.

[0019] Preferably, the diluent is one or more of microcrystalline cellulose, lactose, starch and calcium hydrogen phosphate.

[0020] Preferably, the disintegrant is one or more of cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, corn starch and its derivatives, and sodium alginate.

[0021] Preferably, the precipitation inhibitor is one or more of polycarboxylates, phosphates, organic phosphates, polyepoxysuccinic acid, polyaspartic acid and citric acid.

[0022] The effects of the raw materials involved in the embodiments of the present invention are as follows: Alisma: promotes diuresis and eliminates dampness, dispels heat, clears away heat and promotes urination, and relieves stranguria.

[0023] Poria: diuretic and dampness-eliminating, spleen-strengthening, calming the mind, soothing the nerves, stomachic, and diuretic.

[0024] Poria: promotes diuresis and eliminates dampness, relieves stranguria and reduces swelling.

[0025] Stir-fried Atractylodes macrocephala: strengthens the spleen and replenishes Qi, dries dampness and promotes diuresis, stops sweating, calms the fetus, strengthens the stomach, and harmonizes the middle burner.

[0026] Coix seed: promotes diuresis and eliminates dampness, strengthens the spleen and stops diarrhea, eliminates arthralgia, discharges pus, detoxifies and disperses stagnation, and clears away heat.

[0027] Cinnamon twig: induces sweat and relieves muscles, warms the meridians and dredges blood vessels, assists yang and transforms qi, warms the middle and dispels cold, and relieves exterior symptoms and dispels cold.

[0028] Lotus leaf: clears away heat and relieves summer heat, promotes the development of clear yang, cools blood and stops bleeding, clears the heart and reduces fire, and promotes the elimination of dampness.

[0029] Winter melon peel: diuretic and anti-edema, clears away heat and relieves summer heat, diuretic, clears heat and detoxifies.

[0030] Acorus calamus: invigorates the mind, eliminates dampness and harmonizes the stomach, soothes the mind and improves intelligence, dispels wind and dampness, and clears away heat.

[0031] Hawthorn: helps digestion and eliminates stagnation, promotes qi and disperses blood stasis, eliminates stagnation and eliminates stagnation, lowers blood lipids, and promotes blood circulation.

[0032] Salvia miltiorrhiza: promotes blood circulation and removes blood stasis, promotes menstruation and relieves pain, clears the heart and relieves restlessness, cools blood and eliminates carbuncle, regulates menstruation and calms the mind.

[0033] Panax notoginseng: dissipates blood stasis and stops bleeding, reduces swelling and relieves pain, stops bleeding, promotes blood circulation, and dredges the meridians.

[0034] Leeches: break up blood and remove blood stasis, unblock menstruation, promote blood circulation and reduce swelling.

[0035] Compared with the prior art, the present invention has the following beneficial effects: The invention provides a traditional Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials by weight: 20-30 parts of oriental rhizome, 20-30 parts of tuckahoe, 10-12 parts of umbellatus, 10-12 parts of stir-fried atractylodes macrocephala, 20-30 parts of coix seeds, 10-12 parts of cassia twig, 12-15 parts of lotus leaf, 20-30 parts of wax gourd peel, 10-12 parts of calamus, 10-12 parts of hawthorn, 12-15 parts of salvia miltiorrhiza, 6-10 parts of panax notoginseng and 3-5 parts of leech. The present invention aims at the characteristics of phlegm dampness stasis type obesity, and develops a Chinese medicine composition for treating phlegm dampness stasis type obesity. The prescription of the present invention is composed of 13 Chinese medicines, with oriental rhizome as the main medicine, directly reaching the kidney and bladder, promoting water and removing dampness; with Poria cocos and Polyporus as the ministerial medicine, the main and ministerial medicines are combined to enhance the power of promoting water and removing dampness; therefore, stir-fried atractylodes macrocephala and coix seed are used to strengthen the spleen to transport and transform water and dampness, cinnamon twig warms yang and transforms qi to promote water and dampness, lotus leaf promotes dampness and raises yang, wax gourd peel promotes water and reduces swelling, calamus resolves phlegm and opens the mind, removes dampness and harmonizes the stomach, hawthorn promotes qi and removes blood stasis and eliminates accumulation, salvia miltiorrhiza promotes blood circulation and removes blood stasis, Panax notoginseng disperses blood stasis and reduces swelling, and leeches break blood and remove blood stasis; licorice is used as the guiding medicine to coordinate various medicines so that all medicines can play their strengths. The whole prescription can promote yang and transform qi, promote dampness and promote water, promote blood circulation and remove blood stasis, and blood stasis can be unblocked, and it is effective in treating both the symptoms and the root causes of phlegm dampness stasis type obesity, with significant efficacy and small side effects. The Chinese medicine composition is prepared into an oral preparation, which provides a more stable drug release, avoids drug degradation in gastric acid, and ensures that the drug reaches an effective therapeutic concentration in the body. The preparation is used with pharmaceutically acceptable excipients to prepare a drug, thereby improving the safety of the drug and reducing adverse reactions. DETAILED DESCRIPTION

[0036] In order to facilitate the understanding of the present invention, the present invention will be described more comprehensively below, and preferred embodiments of the present invention are provided. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0037] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0038] The inventive concept of the present invention is as follows: Common weight loss drugs on the market currently include the following categories: First, appetite suppressants, which reduce food intake by stimulating the central nervous system and increasing satiety, but may cause side effects such as insomnia and anxiety, and should not be used for a long time or at night. Second, gastrointestinal lipase inhibitors, which help lose weight by inhibiting fat absorption, have relatively small side effects, but may cause indigestion or respiratory infections. Finally, hormone-based weight loss drugs achieve weight loss by accelerating metabolism and fat decomposition, but excessive use may cause symptoms such as arrhythmia, insomnia, and sweating, so they should be used with caution.

[0039] Based on this, the present invention provides a first aspect of a Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity, which is made of the following Chinese medicinal raw materials by weight: 20 to 30 parts of Alisma orientalis, 20 to 30 parts of Poria cocos, 10 to 12 parts of Polyporus umbellatus, 10 to 12 parts of stir-fried Atractylodes macrocephala, 20 to 30 parts of Coix seeds, 10 to 12 parts of cinnamon twigs, 12 to 15 parts of lotus leaves, 20 to 30 parts of wax gourd peel, 10 to 12 parts of Acorus calamus, 10 to 12 parts of hawthorn, 12 to 15 parts of Salvia miltiorrhiza, 6 to 10 parts of Panax notoginseng, and 3 to 5 parts of leeches.

[0040] The second aspect provides a preparation prepared from a traditional Chinese medicine composition for treating phlegm-dampness and blood stasis type obesity, wherein the preparation is an oral preparation.

[0041] The third aspect provides a drug for treating phlegm-dampness and blood stasis type obesity, the drug comprising the preparation and pharmaceutically acceptable excipients.

[0042] The present invention aims at the characteristics of phlegm dampness stasis type obesity, and develops a Chinese medicine composition for treating phlegm dampness stasis type obesity. The prescription of the present invention is composed of 13 Chinese medicines, with oriental rhizome as the main medicine, directly reaching the kidney and bladder, promoting water and removing dampness; with Poria cocos and Polyporus as the ministerial medicine, the main and ministerial medicines are combined to enhance the power of promoting water and removing dampness; therefore, stir-fried atractylodes macrocephala and coix seed are used to strengthen the spleen to transport and transform water and dampness, cinnamon twig warms yang and transforms qi to promote water and dampness, lotus leaf promotes dampness and raises yang, wax gourd peel promotes water and reduces swelling, calamus resolves phlegm and opens the mind, removes dampness and harmonizes the stomach, hawthorn promotes qi and removes blood stasis and eliminates accumulation, salvia miltiorrhiza promotes blood circulation and removes blood stasis, Panax notoginseng disperses blood stasis and reduces swelling, and leeches break blood and remove blood stasis; licorice is the guiding medicine, and all the medicines are harmonized so that all the medicines can play their strengths. The whole prescription can promote yang and transform qi, promote dampness and promote water, promote blood circulation and remove blood stasis, so that water and dampness cannot be hidden, and blood stasis can be unblocked, and the symptoms and root causes of phlegm dampness stasis type obesity are treated, and the curative effect is remarkable and the side effects are small. The Chinese medicine composition is prepared into an oral preparation, which provides a more stable drug release, avoids drug degradation in gastric acid, and ensures that the drug reaches an effective therapeutic concentration in the body. The preparation is used with pharmaceutically acceptable excipients to prepare a drug, thereby improving the safety of the drug and reducing adverse reactions.

[0043] The technical solution of the present invention will be further described below in conjunction with specific embodiments.

[0044] Example 1 (7) The following Chinese medicinal materials in parts by weight: 20 parts of oriental rhizome, 20 parts of tuckahoe, 10 parts of umbellatus, 10 parts of stir-fried atractylodes macrocephala, 20 parts of coix seed, 10 parts of cinnamon twig, 12 parts of lotus leaf, 20 parts of wax gourd peel, 10 parts of calamus, 10 parts of hawthorn, 12 parts of salvia miltiorrhiza, 6 parts of panax notoginseng, and 3 parts of leech, are mixed to obtain a mixture.

[0045] (8) Add water to the mixture in an amount equivalent to 8 times the volume of the mixture.

[0046] (9) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 6 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 6 times the volume of the residue to the residue.

[0047] (10) Repeat step (3) once, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0048] Example 2 (1) The following Chinese medicinal materials in parts by weight: 20 parts of oriental rhizome, 20 parts of tuckahoe, 10 parts of umbellatus, 10 parts of stir-fried atractylodes macrocephala, 20 parts of coix seed, 10 parts of cinnamon twig, 12 parts of lotus leaf, 20 parts of wax gourd peel, 10 parts of calamus, 10 parts of hawthorn, 12 parts of salvia miltiorrhiza, 6 parts of panax notoginseng, and 3 parts of leech, are mixed to obtain a mixture.

[0049] (2) Add water to the mixture in an amount equivalent to 9 times the volume of the mixture.

[0050] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 7 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 7 times the volume of the residue to the residue.

[0051] (4) Repeat step (3) twice, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0052] Example 3 (1) The following Chinese medicinal materials in parts by weight: 20 parts of oriental rhizome, 20 parts of tuckahoe, 10 parts of umbellatus, 10 parts of stir-fried atractylodes macrocephala, 20 parts of coix seed, 10 parts of cinnamon twig, 12 parts of lotus leaf, 20 parts of wax gourd peel, 10 parts of calamus, 10 parts of hawthorn, 12 parts of salvia miltiorrhiza, 6 parts of panax notoginseng, and 3 parts of leech, are mixed to obtain a mixture.

[0053] (2) Add water to the mixture in an amount equivalent to 10 times the volume of the mixture.

[0054] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 8 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 8 times the volume of the residue to the residue.

[0055] (4) Repeat step (3) three times, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0056] Example 4 (1) The following Chinese medicinal materials in parts by weight: 25 parts of oriental rhizome, 25 parts of tuckahoe, 11 parts of umbellatus, 11 parts of stir-fried atractylodes macrocephala, 25 parts of coix seed, 11 parts of cinnamon twig, 13 parts of lotus leaf, 25 parts of wax gourd peel, 11 parts of calamus, 11 parts of hawthorn, 13 parts of salvia miltiorrhiza, 8 parts of panax notoginseng, and 4 parts of leech, are mixed to obtain a mixture.

[0057] (2) Add water to the mixture in an amount equivalent to 8 times the volume of the mixture.

[0058] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 6 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 6 times the volume of the residue to the residue.

[0059] (4) Repeat step (3) once, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0060] Example 5 (1) The following Chinese medicinal materials in parts by weight: 25 parts of oriental rhizome, 25 parts of tuckahoe, 11 parts of umbellatus, 11 parts of stir-fried atractylodes macrocephala, 25 parts of coix seed, 11 parts of cinnamon twig, 13 parts of lotus leaf, 25 parts of wax gourd peel, 11 parts of calamus, 11 parts of hawthorn, 13 parts of salvia miltiorrhiza, 8 parts of panax notoginseng, and 4 parts of leech, are mixed to obtain a mixture.

[0061] (2) Add water to the mixture in an amount equivalent to 9 times the volume of the mixture.

[0062] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 7 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 7 times the volume of the residue to the residue.

[0063] (4) Repeat step (3) twice, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0064] Example 6 (1) The following Chinese medicinal materials in parts by weight: 25 parts of oriental rhizome, 25 parts of tuckahoe, 11 parts of umbellatus, 11 parts of stir-fried atractylodes macrocephala, 25 parts of coix seed, 11 parts of cinnamon twig, 13 parts of lotus leaf, 25 parts of wax gourd peel, 11 parts of calamus, 11 parts of hawthorn, 13 parts of salvia miltiorrhiza, 8 parts of panax notoginseng, and 4 parts of leech, are mixed to obtain a mixture.

[0065] (2) Add water to the mixture in an amount equivalent to 10 times the volume of the mixture.

[0066] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 8 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 8 times the volume of the residue to the residue.

[0067] (4) Repeat step (3) three times, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0068] Example 7 (1) The following Chinese medicinal materials in parts by weight: 30 parts of oriental rhizome, 30 parts of tuckahoe, 12 parts of umbellatus, 12 parts of stir-fried atractylodes macrocephala, 30 parts of coix seeds, 12 parts of cinnamon twig, 15 parts of lotus leaf, 30 parts of wax gourd peel, 12 parts of calamus, 12 parts of hawthorn, 15 parts of salvia miltiorrhiza, 10 parts of panax notoginseng, and 5 parts of leech, are mixed to obtain a mixture.

[0069] (2) Add water to the mixture in an amount equivalent to 8 times the volume of the mixture.

[0070] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 6 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 6 times the volume of the residue to the residue.

[0071] (4) Repeat step (3) once, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0072] Example 8 (1) The following Chinese medicinal materials in parts by weight: 30 parts of oriental rhizome, 30 parts of tuckahoe, 12 parts of umbellatus, 12 parts of stir-fried atractylodes macrocephala, 30 parts of coix seeds, 12 parts of cinnamon twig, 15 parts of lotus leaf, 30 parts of wax gourd peel, 12 parts of calamus, 12 parts of hawthorn, 15 parts of salvia miltiorrhiza, 10 parts of panax notoginseng, and 5 parts of leech, are mixed to obtain a mixture.

[0073] (2) Add water to the mixture in an amount equivalent to 9 times the volume of the mixture.

[0074] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 7 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 7 times the volume of the residue to the residue.

[0075] (4) Repeat step (3) twice, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0076] Example 9 (1) The following Chinese medicinal materials in parts by weight: 30 parts of oriental rhizome, 30 parts of tuckahoe, 12 parts of umbellatus, 12 parts of stir-fried atractylodes macrocephala, 30 parts of coix seeds, 12 parts of cinnamon twig, 15 parts of lotus leaf, 30 parts of wax gourd peel, 12 parts of calamus, 12 parts of hawthorn, 15 parts of salvia miltiorrhiza, 10 parts of panax notoginseng, and 5 parts of leech, are mixed to obtain a mixture.

[0077] (2) Add water to the mixture in an amount equivalent to 10 times the volume of the mixture.

[0078] (3) Heat, and after boiling, change to low heat and simmer until the remaining liquid is 8 times the volume of the mixture. After stopping the heat, cool down, filter, collect the residue and filtrate, and add water equivalent to 8 times the volume of the residue to the residue.

[0079] (4) Repeat step (3) three times, combine all the filtrates, and obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

[0080] Clinical Trials 1. Diagnostic criteria: Body mass index, also known as BMI, in kg / m 2 , less than 18.5kg / m 2 It is in a low body mass state, reaching 18.5kg / m 2 And less than 24kg / m 2 Normal body mass, reaching 24kg / m 2 And less than 28kg / m 2Overweight: reaching or exceeding 28kg / m 2 For obesity.

[0081] To guide clinical diagnosis and treatment, the degree of obesity needs to be further classified. According to the international obesity classification standards and the characteristics of the Asian population, the Chinese Obesity Diagnosis and Treatment Guidelines, 2024 Edition, recommends that the BMI should reach 28.0 kg / m 2 And less than 32.5kg / m 2 Mild obesity; up to 32.5 kg / m 2 And less than 37.5kg / m 2 Moderate obesity; up to 37.5 kg / m 2 And less than 50kg / m 2 Severe obesity; reaching or exceeding 50kg / m 2 It is extremely severe obesity.

[0082] 2. Inclusion and exclusion criteria: Inclusion criteria: BMI reaches or exceeds 28 kg / m 2 , and meet the main manifestations of phlegm-dampness and stasis-type obesity; Exclusion criteria: BMI less than 28kg / m 2 , or BMI reaches or exceeds 28kg / m 2 , but it does not meet the main manifestations of phlegm-dampness and blood stasis type obesity.

[0083] 3. Clinical research design: 60 cases that met the inclusion criteria were randomly divided into a control group and an observation group, including 30 cases in the control group and 30 cases in the observation group.

[0084] 4. Treatment Methods Control group: Use the dual control method of "exercise + diet" to lose weight.

[0085] (1) Exercise: Calculate the maximum amount of exercise that the patient can tolerate each day, and arrange aerobic exercises such as jogging for the patient within the limit of the maximum amount of exercise. To prevent excessive exercise from causing damage or additional burden to the body, the patient should be informed of the principle of gradual exercise, that is, to exercise in appropriate amounts and at appropriate times every day.

[0086] (2) Diet: Limit starch intake, calculate the calories and sugar content of various foods, and limit calorie and sugar intake while ensuring nutritional balance.

[0087] Observation group: Based on the dual control method of "exercise + diet" of the control group, the Chinese medicine formula disclosed in this application is added, and the dosage is adjusted according to clinical symptoms. Usage: 200 mL of conventional water decoction, 1 dose / d, divided into morning and evening, and taken continuously for 3 months as a course of treatment.

[0088] 5. Observation Project (1) To compare the clinical efficacy between the two groups of patients.

[0089] (2) Compare the body mass index (BMI) of the two groups of patients before and after treatment.

[0090] 6. Observation of therapeutic effects 1) Clinical efficacy evaluation criteria: total effective rate = marked effective rate + effective rate.

[0091] (1) Significant effect: After treatment, the patient's body weight decreased by >5 kg.

[0092] (2) Effective: After treatment, the patient's body weight decreased by 2.5 kg to 5.0 kg.

[0093] (3) Ineffective: After treatment, the patient's body weight loss is <2.5 kg.

[0094] 2) BMI assessment criteria Underweight: BMI<18.5; Normal: BMI between 18.5 and 23.9.

[0095] Overweight: BMI between 24.0 and 27.9; Obese: BMI between 28.0 and 32.0.

[0096] Very obese: BMI>32.0.

[0097] 7. Statistical methods: SPSS 26.0 software was used to process the data. ± standard deviation s indicates t test; count data is X 2 Test. P The difference was statistically significant when the value was <0.05.

[0098] 8. Results 8.1 The effective rate of the observation group was 93.33%, which was higher than 86.67% in the control group. The difference was statistically significant. P <0.05, as shown in Table 1.

[0099] Table 1 Comparison of clinical efficacy between the two groups of patients 8.2 BMI Before treatment, there was no significant difference in BMI between the two groups. P >0.05; after treatment, the BMI of the observation group was lower than that of the control group, and the difference was statistically significant. P <0.05, as shown in Table 2.

[0100] Table 2 Comparison of BMI between the two groups before and after treatment, x±s, kg / m 2 Note: “ / ” means no item.

[0101] The results of the present invention show that the total effective rate of the observation group is higher than that of the control group, indicating that the prescription has a definite clinical efficacy in treating phlegm-dampness and blood stasis type, can effectively reduce the patient's weight, achieve the purpose of treatment, and no side effects are found, which is worthy of clinical promotion and application.

[0102] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0103] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A Chinese medicine composition for treating phlegm-dampness stasis type obesity, characterized in that: It is made from the following Chinese medicinal materials by weight: 20-30 portions of Alisma orientalis, 20-30 portions of Poria cocos, 10-12 portions of Polyporus umbellatus, 10-12 portions of stir-fried Atractylodes macrocephala, 20-30 portions of Coix seeds, 10-12 portions of cinnamon twigs, 12-15 portions of lotus leaves, 20-30 portions of wax gourd peel, 10-12 portions of Acorus calamus, 10-12 portions of hawthorn, 12-15 portions of Salvia miltiorrhiza, 6-10 portions of Panax notoginseng, and 3-5 portions of leeches.

2. The Chinese medicine composition for treating phlegm-dampness stasis type obesity according to claim 1, characterized in that: It is made from the following Chinese medicinal materials by weight: 25 parts of orientalis, 25 parts of tuckahoe, 11 parts of umbellatus, 11 parts of stir-fried atractylodes, 25 parts of coix seeds, 11 parts of cassia twig, 13 parts of lotus leaves, 25 parts of wax gourd peel, 11 parts of calamus, 11 parts of hawthorn, 13 parts of salvia miltiorrhiza, 8 parts of panax notoginseng, and 4 parts of leech.

3. The method for preparing the Chinese medicine composition for treating phlegm-dampness stasis type obesity according to claim 1, characterized in that: include: (1) mixing the Chinese medicinal materials according to weight to obtain a mixture; (2) Add water equivalent to 8 to 10 times the volume of the mixture to the mixture; (3) heating, and then changing to a low heat after boiling until the remaining liquid is 6 to 8 times the volume of the mixture, stopping the heat and cooling, filtering, collecting the residue and the filtrate, and adding water equivalent to 6 to 8 times the volume of the residue; (4) Repeat step (3) at least once, and combine all the filtrates to obtain the Chinese medicine composition for treating phlegm-dampness stasis type obesity.

4. A preparation prepared from the Chinese medicine composition for treating phlegm-dampness stasis type obesity as claimed in claim 1, characterized in that: The preparation is an oral preparation.

5. A preparation prepared from the Chinese medicine composition for treating phlegm-dampness stasis type obesity as claimed in claim 4, characterized in that: The oral preparation is a decoction.

6. A drug for treating phlegm-dampness stasis type obesity, characterized in that: The drug comprises the preparation according to claim 4 or claim 5, and further comprises pharmaceutically acceptable excipients.

7. The drug for treating phlegm-dampness stasis type obesity according to claim 6, characterized in that: The medicine is prepared from the preparation and pharmaceutically acceptable auxiliary materials.

8. The drug for treating phlegm-dampness stasis type obesity according to claim 6, characterized in that: The pharmaceutically acceptable drug excipient is one or more of a diluent, a disintegrant, a precipitation inhibitor, a glidant, a binder, a dispersant, a suspending agent, an isotonic agent, a thickener, an emulsifier, a preservative and a stabilizer.

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