Traditional Chinese medicine compound preparation for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Abstract

The invention relates to the technical field of medicine preparation, and discloses a traditional Chinese medicine compound preparation for dredging cardiovascular and cerebrovascular diseases and a preparation method thereof.The traditional Chinese medicine compound preparation is prepared from, by weight, 8-15 parts of pseudo-ginseng, the pseudo-ginseng has the effects of dissipating blood stasis, stopping bleeding, diminishing swelling and relieving pain, and by increasing the dosage of the pseudo-ginseng, blood circulation can be strengthened, blood stasis can be removed, blood circulation can be promoted, and the remarkable effect on dredging cardiovascular and cerebrovascular diseases is achieved; 6-12 parts of Dendrobium candidum, which can enhance the ability of nourishing yin and clearing heat, is helpful for improving the sticky state of blood, and provides a better nourishing environment for heart and cerebral vessels; the ligusticum wallichii can activate blood, promote qi circulation, dispel wind and relieve pain, the qi and blood circulation promoting effect can be further improved by increasing the dosage, and qi and blood circulation of heart and cerebral vessels is improved. The medicinal materials in the formula are reasonably proportioned and prepared, blood circulation can be promoted, qi and blood circulation of heart and cerebral vessels can be improved, the risk of blood vessel blockage can be reduced, three composite medicinal material extracts are added for auxiliary matching, the heart and cerebral vessel dredging capacity can be remarkably enhanced, and blood pressure and blood fat can be remarkably reduced.

Description

Technical Field

[0001] The invention relates to the technical field of drug preparation, in particular to a Chinese medicine compound preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background Art

[0002] Cardiovascular and cerebrovascular diseases are a common disease that seriously threatens human health, with the characteristics of high morbidity, high disability rate and high mortality rate. In the field of traditional medicine, Chinese herbal compound preparations play an important role in the prevention and treatment of cardiovascular and cerebrovascular diseases. At present, there are many Chinese herbal compound preparations for cardiovascular and cerebrovascular diseases on the market. These preparations are usually made up of a variety of Chinese medicinal materials. According to the theory of traditional Chinese medicine, by regulating the balance of human qi and blood, yin and yang, they can achieve the effects of promoting blood circulation and removing blood stasis, dredge meridians and relieve pain, and regulate qi and resolve phlegm. However, there are still differences in the rationality and effectiveness of the existing Chinese herbal compound preparations. Different compatibility combinations and dosages of medicinal materials lead to uneven therapeutic effects.

[0003] When preparing these traditional Chinese medicine compound preparations, commonly used mechanical technologies include crushing, mixing, and granulation. Crushing equipment such as high-speed crushers and universal crushers use high-speed rotating blades or hammers to crush the medicinal materials into fine powder to increase the surface area of ​​the medicinal materials and facilitate the dissolution of the active ingredients. Mixing equipment uses stirring, tumbling, etc. to evenly mix the fine powders of different medicinal materials to ensure that the content of each ingredient in the preparation is consistent.

[0004] In actual application scenarios, for example, a patient who has suffered from cardiovascular and cerebrovascular diseases for a long time, after taking the existing Chinese medicine compound preparation, although the symptoms are relieved, the ideal therapeutic effect is still not achieved. This is mainly because the prior art has the following problems. In terms of formula, some preparations fail to fully consider the synergistic effect between medicinal materials, and cannot fully exert the effects of clearing cardiovascular and cerebrovascular vessels, dissolving nodules, and dissolving arterial plaques. The present invention provides a Chinese medicine compound preparation for clearing cardiovascular and cerebrovascular diseases and a preparation method thereof to solve the deficiencies in the prior art. Summary of the invention

[0005] In view of the deficiencies of the prior art, the present invention provides a Chinese herbal compound preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, which solves the problems that the Chinese herbal compound preparation for treating cardiovascular and cerebrovascular diseases in the prior art has a single effect, is difficult to provide a comprehensive therapeutic effect, and is difficult to balance between efficacy and cost.

[0006] To achieve the above purpose, the present invention is implemented by the following technical scheme: a Chinese medicine compound preparation for treating cardiovascular and cerebrovascular diseases, comprising the following components in parts by weight:

[0007] Panax notoginseng: 8-15 parts. Panax notoginseng has the effects of dispersing blood stasis, stopping bleeding, reducing swelling and relieving pain. Increasing its dosage can enhance blood circulation and blood stasis, promote blood circulation, and has a significant effect on cardiovascular and cerebrovascular clearance.

[0008] Tiepi Fengdou: 6-12 servings, which can enhance the ability to nourish yin and clear away heat, help improve blood viscosity, and provide a better nourishing environment for the cardiovascular and cerebrovascular systems;

[0009] Chuanxiong: 8-15 servings. Chuanxiong can invigorate blood circulation, dispel wind and relieve pain. Increasing the dose can further enhance the effect of invigorating blood circulation and improve the circulation of qi and blood in the cardiovascular and cerebrovascular systems.

[0010] American ginseng: 6-12 servings, to enhance the effect of replenishing qi and nourishing yin, provide sufficient qi and blood support for the operation of cardiovascular and cerebrovascular vessels, and reduce blood vessel obstruction caused by insufficient qi and blood;

[0011] Curcuma: 6-12 parts, which can enhance the effects of promoting qi and removing blood stasis, clearing the heart and relieving depression, help to clear the stagnation of cardiovascular and cerebrovascular vessels, and improve blood supply to the heart and brain;

[0012] Salvia miltiorrhiza: 8-15 servings. Salvia miltiorrhiza can invigorate blood circulation, remove blood stasis, relieve menstruation and relieve pain. Increasing the dosage can significantly enhance the ability to open the cardiovascular and cerebrovascular system and improve microcirculation.

[0013] Leeches: 2-6 servings. Leeches have a strong effect in removing blood stasis. Appropriate additions can better eliminate blood stasis in blood vessels and promote cardiovascular and cerebrovascular function.

[0014] Hawthorn: 8-15 servings, which can enhance the effects of digestion, promoting blood circulation and removing blood stasis, help lower blood lipids, reduce the risk of blood vessel blockage, and indirectly protect the cardiovascular and cerebrovascular systems;

[0015] Cat’s Claw: 6-12 parts, enhances the effect of resolving phlegm and dispersing nodules, helps dissipate abnormal accumulation in blood vessels, and plays a certain auxiliary role in opening up the cardiovascular and cerebrovascular system;

[0016] Tangerine peel: 5-10 servings, which can enhance the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and help regulate qi and create good conditions for the circulation of qi and blood in the cardiovascular and cerebrovascular systems;

[0017] Chicken gizzard lining: 8-12 servings, enhances the effects of strengthening the stomach and digestion, relieving stranguria and relieving constipation, promotes digestion and absorption, improves the body's overall nutritional status, and indirectly supports cardiovascular and cerebrovascular health;

[0018] Clove: 3-6 parts, which can warm the middle and lower adverse reactions, dispel cold and relieve pain, improve blood circulation, and have a certain warming effect on the cardiovascular and cerebrovascular systems;

[0019] Earthworm: 6-10 portions, which can enhance the effects of clearing away heat and calming nerves, unblocking meridians and relieving asthma, and help dredge meridians and improve cardiovascular and cerebrovascular blood circulation;

[0020] Paris polyphylla: 4-9 parts, enhances the effects of clearing away heat and detoxification, reducing swelling and relieving pain, improves the intravascular environment, and has a certain auxiliary effect on cardiovascular and cerebrovascular function;

[0021] Buffalo horn: 6-10 servings, which can enhance the effects of clearing heat and cooling blood, detoxifying and calming nerves, helping to improve the heat signs of the blood and prevent vascular inflammation and blockage;

[0022] Vinegar vine: 5-10 portions, enhances the effects of dispelling wind and dampness, promoting blood circulation and detoxification, plays an auxiliary role in opening up the cardiovascular and cerebrovascular vessels, and improves local blood circulation;

[0023] Blood-activating auxiliary materials: 8-15 parts. Ginkgo biloba can activate blood circulation, dissipate blood stasis and dredge collaterals, while astragalus can replenish qi, raise yang, consolidate the exterior and stop sweating. The combination of the two can enhance the effect of replenishing qi and activating blood circulation, which is beneficial for cardiovascular and cerebrovascular diseases.

[0024] Antipyretic auxiliary materials: 6-12 parts, Pueraria root can relieve muscle and reduce fever, promote body fluid and quench thirst, raise yang and stop diarrhea, while Angelica sinensis can replenish blood and activate blood circulation, regulate menstruation and relieve pain, and moisten the intestines and promote bowel movements. The combination of the two can enhance the effects of activating blood circulation and replenishing blood, unblocking meridians, and is beneficial to improving cardiovascular and cerebrovascular circulation;

[0025] Blood stasis-removing auxiliary materials: 6-10 parts. Safflower can promote blood circulation, relieve menstruation, dissipate blood stasis and relieve pain, while peach kernel can promote blood circulation, remove blood stasis and moisten the intestines to promote bowel movements. The combination of the two can enhance the ability to promote blood circulation and remove blood stasis, and help dissolve arterial plaques.

[0026] Preferably, the preparation of the blood-activating auxiliary material comprises: mixing ginkgo biloba leaves and astragalus in a ratio of 1:1; adding supercritical CO 2 Extraction equipment, extraction according to parameters; the extract is concentrated by vacuum concentration equipment, and then dried into powder by freeze drying machine. In the preparation step of the blood-activating auxiliary material, supercritical CO 2 The extraction pressure is 30-40 MPa, the temperature is 40-50°C, and the extraction time is 3-3.5 h; the vacuum concentration temperature is 50-60°C, and the vacuum degree is -0.08-0.1 MPa; the pre-freezing temperature of freeze drying is -40-30°C, the sublimation temperature is -20-10°C, the decomposition temperature is 30-40°C, and the supercritical CO 2 Extraction equipment (model: HA221-50-06, extraction kettle volume 50L), vacuum concentration equipment (model: SZ-1000, evaporation area 1000㎡), freeze dryer (model: LGJ-10, freeze drying area 10㎡).

[0027] Preferably, the preparation of the antipyretic auxiliary material includes: mixing Pueraria root and Angelica sinensis in a ratio of 2:1 and then adding an appropriate amount of water; placing in an ultrasonic-assisted extraction device for extraction; centrifuging the extract through a high-speed centrifugal device, taking the supernatant, and drying it into a powder using a spray drying device. In the preparation step of the antipyretic auxiliary material, the ratio of medicinal materials to water during ultrasonic-assisted extraction is 1:10, and the extraction time is 30 to 40 minutes; the centrifugation time of high-speed centrifugation is 15 to 30 minutes; the feed rate of spray drying is 50 to 60 mL / min, ultrasonic-assisted extraction equipment (model: KQ-500DE, power 500W, frequency 40kHz), high-speed centrifugal equipment (model: TDL-5-A, speed 5000r / min), spray drying equipment (model: LPG-50, air inlet temperature 180°C, air outlet temperature 80°C).

[0028] Preferably, the preparation of the stasis-removing auxiliary material includes: mixing safflower and peach kernel in a ratio of 1:1, adding an appropriate amount of ethanol; extracting in a microwave-assisted extraction device; concentrating the extract by a rotary evaporation device, and then drying it into a powder in a vacuum drying oven. In the preparation steps of the stasis-removing auxiliary material, the extraction time of the microwave-assisted extraction is 10 to 15 minutes; the temperature of the rotary evaporation is 60 to 70°C; the drying time of the vacuum drying is 5 to 5.5 hours, and the microwave-assisted extraction device (model: MAS-II, power 600W), the rotary evaporation device (model: RE-52AA, evaporation flask volume 500mL), and the vacuum drying oven (model: DZF-6020, temperature 50°C, vacuum degree -0.09MPa).

[0029] The present invention also provides a method for preparing a Chinese medicine compound preparation for treating cardiovascular and cerebrovascular diseases, comprising the following steps:

[0030] S1. Grind all the medicinal materials and three auxiliary materials with a universal grinder;

[0031] S2. Put the crushed fine powder into a three-dimensional motion mixer and mix for 30 to 40 minutes;

[0032] S3, adding a binder to the mixed powder, and placing it into a high-efficiency wet granulator for granulation;

[0033] S4, drying the prepared wet granules with a fluidized bed dryer to remove moisture;

[0034] S5. The dried granules are sieved to remove adhesion and fine powder;

[0035] S6, pressing the granules into tablets using a rotary tablet press;

[0036] S7. Coat the compressed tablets using a high-efficiency coating machine.

[0037] Preferably, in the step S1, all the medicinal materials and three auxiliary materials are put into a universal grinder, and the materials are crushed by a high-speed rotating blade. This step is intended to reduce the particle size of the material, increase the specific surface area, and improve the efficiency of subsequent mixing, extraction and other operations. The crushing particle size can be adjusted between 80 and 200 meshes according to the characteristics of the medicinal materials. For medicinal materials with a hard texture, a smaller crushing particle size (150 to 200 meshes) can be selected to ensure sufficient crushing; for medicinal materials with a softer texture, a larger crushing particle size (80 to 120 meshes) can be selected to avoid excessive crushing to produce too much fine powder.

[0038] Preferably, in the step S2, the crushed fine powder is placed in a three-dimensional motion mixer. This mixer uses a unique three-dimensional motion mode to make the materials tumble and mix in multiple directions, thereby achieving a uniform mixing effect. The mixing time is generally set to 30 minutes. On this basis, it can be appropriately adjusted between 20 and 40 minutes according to the total amount of materials and the mixing uniformity requirements. When the total amount of materials is large, the mixing time can be appropriately extended to 35 to 40 minutes; if the mixing uniformity requirements are extremely high, the mixing time can also be appropriately extended.

[0039] Preferably, in the step S3, a proper amount of binder is added to the mixed powder, and the mixture is placed in a high-efficiency wet granulator. The powder is made into wet granules with a certain size and shape through the synergistic effect of the stirring paddle and the granulating knife. The stirring speed is generally 300 r / min, which can be adjusted between 200 and 400 r / min according to the properties of the powder and the amount of binder. When the powder is more viscous, the stirring speed can be appropriately reduced to 200 to 250 r / min; when the powder is less viscous, the stirring speed can be appropriately increased to 350 to 400 r / min. The granulation time is generally 15 minutes, which can be adjusted between 15 and 30 minutes according to the particle forming conditions.

[0040] Preferably, in the step S4, the prepared wet granules are fed into a fluidized bed dryer, and hot air enters from the bottom, so that the granules are fully in contact with the hot air in a fluidized state, thereby quickly removing moisture. The inlet air temperature is generally set to 80°C, and can be adjusted between 60 and 100°C according to the thermal sensitivity of the material. For medicinal extracts with higher thermal sensitivity, the inlet air temperature can be controlled at 60 to 70°C; for materials with lower thermal sensitivity, the inlet air temperature can be appropriately increased to 90 to 100°C, the outlet air temperature is 40 to 50°C, and the drying time is 20 minutes.

[0041] Preferably, in the step S5, the dried particles are adhered and have fine powder, and a sieve is used to perform granulation, and the particles and fine powder that do not meet the particle size requirements are removed by screening with the sieve to make the particle size more uniform. The mesh number of the sieve can be selected between 10 and 40 meshes according to the dosage form of the drug and the particle requirements. When preparing capsules, a 16-20 mesh sieve can be selected; when preparing tablets, a 20-30 mesh sieve can be selected.

[0042] Preferably, in the step S6, the whole granules are pressed into tablets using a rotary tablet press, and the granules are compacted and formed in a mold by adjusting the pressure. The pressure range is generally 10 to 80 kN, and can be adjusted between 8 and 100 kN according to the hardness requirements of the tablets and the properties of the particles. For tablets with higher hardness requirements, the pressure can be controlled at 50 to 80 kN; for granules with a loose texture, the pressure can be appropriately reduced to 10 to 20 kN.

[0043] Preferably, in the step S7, the compressed tablets are coated with a high-efficiency coating machine, and a layer of coating material is evenly applied on the surface of the tablets to increase the stability and aesthetics of the tablets and improve the release performance of the drug. The coating time is generally 30 minutes, which can be adjusted between 20 and 40 minutes according to the type of coating material and the coating thickness requirement. When a water-soluble coating material is used, the coating time can be appropriately shortened to 20 to 25 minutes; when an enteric coating material is used, the coating time can be appropriately extended to 35 to 40 minutes. The coating temperature is generally 40°C and can be adjusted between 35 and 45°C.

[0044] The present invention provides a Chinese medicine compound preparation for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. It has the following beneficial effects:

[0045] 1. The present invention can promote blood circulation, improve the circulation of qi and blood in the cardiovascular and cerebrovascular systems, and reduce the risk of blood vessel blockage by rationally proportioning and preparing the medicinal materials in the formula. Adding three composite medicinal material extracts for auxiliary coordination can significantly enhance the ability to clear the cardiovascular and cerebrovascular systems, and can significantly lower blood pressure and blood lipids. For cardiovascular and cerebrovascular diseases such as hypertension and arteriosclerosis caused by abnormal blood pressure and blood lipids, the condition can be alleviated from the root and the risk of the disease can be reduced.

[0046] 2. The present invention, through the synergistic effect of various medicinal materials, is helpful to dissipate abnormal accumulation in blood vessels, resolve phlegm and resolve nodules, regulate body functions, and achieve the effect of dissolving nodules and arterial plaques. Five medicinal materials such as hawthorn, cat's claw, tangerine peel, chicken's gizzard lining, and clove play a key auxiliary role in this process, which can significantly improve the efficacy of the medicine, effectively improve blood rheology, enhance blood fluidity, reduce blood viscosity, and reduce the possibility of thrombosis. It has a positive preventive and therapeutic effect on thrombosis-related diseases such as cerebral infarction.

[0047] 3. The present invention can replenish qi and nourish yin, regulate qi and strengthen the spleen, strengthen the stomach and aid digestion, promote digestion and absorption, improve the body's overall nutritional status, provide support for cardiovascular and cerebrovascular health, and indirectly maintain the body in good condition. A higher content of effective ingredients helps to promote the dissolution of arterial plaques, restore vascular elasticity, improve vascular stenosis, and has a good therapeutic effect on cardiovascular diseases such as coronary heart disease caused by arterial plaques. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 It is a process flow chart of the present invention. DETAILED DESCRIPTION

[0049] The following will be combined with the drawings in the specification of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0050] Please see attached Figure 1 :

[0051] Embodiment 1:

[0052] Medicinal material ratio:

[0053] Notoginseng: 10 parts, Cangzhu: 8 parts, Chuanxiong: 10 parts, American ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Crataegus: 10 parts, Cat's Claw: 8 parts, Tangerine peel: 8 parts, Chicken gizzard lining: 10 parts, Clove: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo horn: 8 parts, Vajrapani: 8 parts.

[0054] Preparation process:

[0055] Put all medicinal materials into a universal grinder, set the grinding particle size to 120 mesh, grind the material with a high-speed rotating blade, put the crushed fine powder into a three-dimensional motion mixer, set the mixing time to 30 minutes, add an appropriate amount of starch slurry as a binder to the mixed powder, put it into a high-efficiency wet granulator, set the stirring speed to 300r / min, and the granulation time to 15 minutes. Send the prepared wet granules into a fluidized bed dryer, set the inlet air temperature to 80°C, the outlet air temperature to 40°C, and the drying time to 20 minutes. Use a 25-mesh screen to sieve the dried granules, press the sized granules into tablets with a rotary tablet press, set the pressure to 40kN, and adjust the pressure to compact and shape the granules in the mold. Use an efficient coating machine to coat the compressed tablets, set the coating time to 30 minutes, and the coating temperature to 40°C to obtain a finished drug product.

[0056] Comparative Example 1:

[0057] Medicinal material ratio:

[0058] Notoginseng: 15 parts, Cangzhu: 6 parts, Chuanxiong: 8 parts, American ginseng: 12 parts, Curcuma: 6 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Crataegus: 10 parts, Cat's Claw: 8 parts, Tangerine Peel: 8 parts, Chicken Gizzard Stone: 10 parts, Clove: 4 parts, Pheretima: 6 parts, Paris polyphylla: 9 parts, Buffalo Horn: 6 parts, Vajrapani: 5 parts.

[0059] The amounts of hawthorn, cat's claw, tangerine peel, chicken's gizzard lining, and cloves are kept consistent with those in Example 1, and the amounts of other medicinal materials are adjusted.

[0060] Preparation process:

[0061] The preparation process of this comparative example is completely consistent with the preparation process of Example 1.

[0062] Embodiment 2:

[0063] Medicinal material ratio:

[0064] Notoginseng: 10 parts, Officinal Maple: 8 parts, Chuanxiong: 10 parts, American Ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Hawthorn: 10 parts, Cat's Claw: 8 parts, Tangerine Peel: 8 parts, Chicken Gizzard Stone: 10 parts, Clove: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo Horn: 8 parts, Vajrapani: 8 parts, Blood Activating Supplementary Materials: 10 parts.

[0065] The medicinal material ratio of this embodiment is consistent with the type and number of medicinal materials in Example 1, and 10 parts of blood-activating auxiliary materials are added.

[0066] Preparation process:

[0067] When preparing the blood-activating auxiliary material, ginkgo leaves and astragalus are mixed in a ratio of 1:1; supercritical CO is added 2 Extraction equipment, the extract is concentrated by vacuum concentration equipment, and then dried into powder extract by freeze drying machine, in which supercritical CO 2 The extraction pressure is 30MPa, the temperature is 40°C, and the extraction time is 3h; the temperature of vacuum concentration is 50°C, and the vacuum degree is -0.08MPa; the pre-freezing temperature of freeze-drying is -40°C, the sublimation temperature is -20°C, and the decomposition temperature is 30°C; the overall preparation process of this embodiment is consistent with the preparation process of Example 1.

[0068] Comparative Example 2:

[0069] Medicinal material ratio:

[0070] The types and quantities of medicinal materials in this comparative example are consistent with the medicinal material proportions in Example 2.

[0071] Preparation process:

[0072] When preparing the blood-activating auxiliary material, ginkgo leaves and astragalus are mixed in a ratio of 1:1; supercritical CO is added 2 Extraction equipment, the extract is concentrated by vacuum concentration equipment, and then dried into powder extract by freeze drying machine, in which supercritical CO 2 The extraction pressure was 25 MPa, the temperature was 35 ° C, and the extraction time was 2.5 h; the vacuum concentration temperature was 50 ° C, and the vacuum degree was -0.08 MPa; the pre-freezing temperature of freeze drying was -40 ° C, the sublimation temperature was -20 ° C, and the decomposition temperature was 30 ° C; the overall preparation process of this comparative example was consistent with the preparation process of Example 2, except that supercritical CO was used in the preparation of the blood-activating auxiliary material. 2 Adjust the extraction pressure, temperature and extraction time.

[0073] Embodiment 3:

[0074] Medicinal material ratio:

[0075] Notoginseng: 10 parts, Officinal Maple: 8 parts, Chuanxiong: 10 parts, American Ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Hawthorn: 10 parts, Cat's Claw: 8 parts, Tangerine Peel: 8 parts, Chicken Gizzard Stone: 10 parts, Clove: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo Horn: 8 parts, Vajrapani: 8 parts, Blood Activating Supplementary Materials: 10 parts, Antipyretic Supplementary Materials: 8 parts.

[0076] The medicinal material ratio of this embodiment is consistent with the type and number of medicinal materials in Example 2, and 8 portions of antipyretic auxiliary materials are added.

[0077] Preparation process:

[0078] When preparing the antipyretic auxiliary material, Pueraria root and Angelica sinensis are mixed in a ratio of 2:1 and then an appropriate amount of water is added; the mixture is placed in an ultrasonic-assisted extraction device for extraction; the extract is centrifuged through a high-speed centrifugal device, the supernatant is taken, and the extract is dried into a powdered extract using a spray drying device, wherein the ratio of medicinal materials to water during ultrasonic-assisted extraction is 1:10, and the extraction time is 40 minutes; the centrifugation time of the high-speed centrifugation is 30 minutes; the feed rate of the spray drying is 60 mL / min, and the overall preparation process of this embodiment is consistent with the preparation process of Example 2.

[0079] Comparative Example 3:

[0080] Medicinal material ratio:

[0081] The types and quantities of medicinal materials in this comparative example are consistent with the medicinal material proportions in Example 3.

[0082] Preparation process:

[0083] When preparing the antipyretic auxiliary material, Pueraria lobata and Angelica sinensis are mixed in a ratio of 2:1 and then an appropriate amount of water is added; the mixture is placed in an ultrasonic-assisted extraction device for extraction; the extract is centrifuged through a high-speed centrifuge, the supernatant is taken, and the extract is dried into a powdered extract using a spray drying device, wherein the ratio of medicinal materials to water during ultrasonic-assisted extraction is 1:8, and the extraction time is 35 minutes; the centrifugation time of high-speed centrifugation is 25 minutes; the feed rate of spray drying is 60 mL / min, and the overall preparation process of this comparative example remains consistent with the preparation process of Example 3, and only the ratio of medicinal materials to water, the extraction time, and the centrifugation time of high-speed centrifugation are adjusted during ultrasonic-assisted extraction.

[0084] Embodiment 4:

[0085] Medicinal material ratio:

[0086] Notoginseng: 10 parts, Cangzhu: 8 parts, Chuanxiong: 10 parts, American ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Hawthorn: 10 parts, Cat's Claw: 8 parts, Tangerine Peel: 8 parts, Chicken Gizzard Stone: 10 parts, Clove: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo Horn: 8 parts, Vajrapani: 8 parts, Blood circulation auxiliary materials: 10 parts, Antipyretic auxiliary materials: 8 parts, Blood stasis auxiliary materials: 6 parts.

[0087] The medicinal material ratio of this embodiment is consistent with the type and number of medicinal materials in Example 3, and 6 parts of blood stasis-removing auxiliary materials are added.

[0088] Preparation process:

[0089] When preparing the stasis-removing auxiliary material, safflower and peach kernel are mixed in a ratio of 1:1, and an appropriate amount of ethanol is added; the mixture is put into a microwave-assisted extraction device for extraction; the extract is concentrated by a rotary evaporation device, and then dried into a powdered extract in a vacuum drying oven, wherein the extraction time of the microwave-assisted extraction is 15 minutes; the temperature of the rotary evaporation is 70°C; the drying time of the vacuum drying is 5.5 hours, and the overall preparation process of this embodiment is consistent with the preparation process of Example 3.

[0090] Comparative Example 4:

[0091] Medicinal material ratio:

[0092] The types and quantities of medicinal materials in this comparative example are consistent with the medicinal material proportions in Example 4.

[0093] Preparation process:

[0094] When preparing the stasis-removing auxiliary material, safflower and peach kernel are mixed in a ratio of 1:1, and an appropriate amount of ethanol is added; the mixture is put into a microwave-assisted extraction device for extraction; the extract is concentrated by a rotary evaporation device, and then dried into a powdered extract in a vacuum drying oven, wherein the extraction time of the microwave-assisted extraction is 15 minutes; the temperature of the rotary evaporation is 65°C; the drying time of the vacuum drying is 5 hours. The overall preparation process of this comparative example remains consistent with the preparation process of Example 4, and only the temperature of the rotary evaporation and the drying time of the vacuum drying are adjusted when preparing the stasis-removing auxiliary material.

[0095] Embodiment 5:

[0096] Medicinal material ratio:

[0097] Notoginseng: 10 parts, Cangzhu: 8 parts, Chuanxiong: 10 parts, American ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Hawthorn: 10 parts, Cat's Claw: 8 parts, Tangerine Peel: 8 parts, Chicken Gizzard Stone: 10 parts, Clove: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo Horn: 8 parts, Vajrapani: 8 parts, Blood circulation auxiliary materials: 12 parts, Antipyretic auxiliary materials: 10 parts, Blood stasis auxiliary materials: 8 parts.

[0098] Preparation process:

[0099] The preparation process of this comparative example is completely consistent with the preparation process of Example 4.

[0100] Comparative Example 5:

[0101] Medicinal material ratio:

[0102] Notoginseng: 10 parts, Cangzhu: 8 parts, Chuanxiong: 10 parts, American ginseng: 8 parts, Curcuma: 8 parts, Salvia miltiorrhiza: 10 parts, Leech: 4 parts, Pheretima: 8 parts, Paris polyphylla: 6 parts, Buffalo horn: 8 parts, Vajrapani: 8 parts, blood circulation auxiliary materials: 12 parts, fever-removing auxiliary materials: 10 parts, blood stasis-removing auxiliary materials: 8 parts.

[0103] The types and quantities of medicinal materials in this comparative example are consistent with those in Example 5, except that five medicinal materials, namely, hawthorn, cat's claw, tangerine peel, chicken's gizzard lining, and clove, are removed.

[0104] Preparation process:

[0105] The preparation process of this comparative example is completely consistent with the preparation process of Example 5.

[0106] Materials included in the experiment:

[0107] Medicinal materials: Panax notoginseng, officinal maple, Chuanxiong, American ginseng, Curcuma, Salvia miltiorrhiza, leech, earthworm, Paris polyphylla, buffalo horn, Vajra vine, blood-activating auxiliary materials, fever-removing auxiliary materials, blood-stasis-removing auxiliary materials

[0108] Equipment: universal pulverizer (model: FW100), three-dimensional motion mixer (model: SYH-500), high-efficiency wet granulator (model: GHL-500), fluidized bed dryer (model: FBD-100), rotary tablet press (model: ZP-35A), high-efficiency coating machine (model: BGB-150), supercritical CO 2 Extraction equipment (model: HA221-50-06), vacuum concentration equipment (model: SZ-1000), freeze dryer (model: LGJ-10), ultrasonic assisted extraction equipment (model: KQ-500DE), high-speed centrifuge equipment (model: TDL-5-A), spray drying equipment (model: LPG-50), microwave assisted extraction equipment (model: MAS-II), rotary evaporation equipment (model: RE-52AA), vacuum drying oven (model: DZF-6020), high performance liquid chromatograph (for detecting the content of active ingredients in drugs), animal experimental equipment (such as mouse cages, gavage apparatus, etc., for animal experimental efficacy verification)

[0109] Experimental steps:

[0110] 1. Preparation of medicinal materials and extracts: Prepare medicinal materials according to the formulas of the above examples and comparative examples, prepare three composite medicinal material extracts (blood circulation auxiliary material, fever-removing auxiliary material, and blood stasis-removing auxiliary material), and strictly control the preparation process parameters.

[0111] 2. Drug preparation:

[0112] Crush the medicinal materials with a universal grinder;

[0113] Mix the crushed medicinal materials and extracts with a three-dimensional motion mixer;

[0114] Add a binder and granulate using a high-efficiency wet granulator;

[0115] Drying the wet granules with a fluid bed dryer;

[0116] Use a sieve to sieve the grains;

[0117] Tablets are pressed using a rotary tablet press;

[0118] Coating with a high-efficiency coating machine.

[0119] 3. Drug testing: Use high performance liquid chromatography to detect the content of active ingredients in drugs.

[0120] 4. Animal experiment: Healthy mice were selected and randomly divided into 10 groups, with 10 mice in each group. The 10 groups of mice were gavaged with drugs prepared with different formulas, and the control group was gavaged with normal saline. The blood pressure, blood lipids, blood rheology and other indicators of the mice were regularly tested, and the behavior and physical signs of the mice were observed. Finally, the following data were obtained as shown in the table.

[0121]

[0122]

[0123] Summary: Through the detection of the content of active ingredients in drugs with different formulas and the verification of the efficacy of animal experiments, the results show that the formula of Example 5 has significant advantages in the treatment of cardiovascular and cerebrovascular diseases. The increased number of composite medicinal extracts is reasonable and can cooperate with other medicinal materials to exert better efficacy. In the comparative example, changing the number of medicinal materials, the preparation process parameters of the composite medicinal extracts or removing some medicinal materials all led to a decrease in the efficacy of the drugs to varying degrees. This experiment provides a strong experimental basis for the optimization of the formula of drugs for the treatment of cardiovascular and cerebrovascular diseases.

[0124] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases, characterized in that: The Chinese medicine compound preparation comprises the following components in parts by weight: Panax notoginseng: 8-15 parts, Cangzhu: 6-12 parts, Chuanxiong: 8-15 parts, American ginseng: 6-12 parts, Curcuma: 6-12 parts, Salvia miltiorrhiza: 8-15 parts, Leech: 2-6 parts, Crataegus: 8-15 parts, Cat's Claw: 6-12 parts, Tangerine peel: 5-10 parts, Chicken gizzard lining: 8-12 parts, Clove: 3-6 parts, Pheretima: 6-10 parts, Paris polyphylla: 4-9 parts, Buffalo horn: 6-10 parts, Vajrapani: 5-10 parts, Blood circulation promoting auxiliary material: 8-15 parts, Antipyretic auxiliary material: 6-12 parts, Blood stasis removing auxiliary material: 6-10 parts.

2. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The preparation of the blood-activating auxiliary material comprises: Mix Ginkgo biloba and Astragalus in a 1:1 ratio; Put it into supercritical CO2 extraction equipment for extraction; The extract is concentrated by a vacuum concentration device and then dried by a freeze dryer to obtain a powdered blood-activating auxiliary material.

3. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 2, characterized in that: In the preparation steps of the blood-activating auxiliary material, the pressure of supercritical CO2 extraction is 30-40MPa, the temperature is 40-50°C, and the extraction time is 3-3.5h; the temperature of vacuum concentration is 50-60°C, and the vacuum degree is -0.08-0.1MPa; the pre-freezing temperature of freeze-drying is -40--30°C, the sublimation temperature is -20--10°C, and the decomposition temperature is 30-40°C.

4. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The preparation of the antipyretic auxiliary material comprises: Mix Pueraria root and Angelica sinensis in a ratio of 2:1 and add appropriate amount of water; Place in ultrasonic assisted extraction equipment for extraction; The extract is centrifuged through a high-speed centrifugal device, the supernatant is taken, and dried through a spray drying device to obtain a powdered antipyretic auxiliary material.

5. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 4, characterized in that: In the preparation steps of the antipyretic auxiliary material, the ratio of medicinal materials to water during ultrasound-assisted extraction is 1:10, and the extraction time is 30 to 40 minutes; the centrifugation time of high-speed centrifugation is 15 to 30 minutes; and the feed rate of spray drying is 50 to 60 mL / min.

6. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The preparation of the stasis-removing auxiliary material comprises: Mix safflower and peach kernel in a ratio of 1:1 and add appropriate amount of ethanol; Place in microwave-assisted extraction equipment for extraction; The extract is concentrated by a rotary evaporation device and then dried in a vacuum drying oven to obtain a powdered stasis-removing auxiliary material.

7. The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 6, characterized in that: In the preparation step of the stasis-removing auxiliary material, the extraction time of microwave-assisted extraction is 10 to 15 minutes; the temperature of rotary evaporation is 60 to 70° C.; and the drying time of vacuum drying is 5 to 5.5 hours.

8. The method for preparing the Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 1, characterized in that: The Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases as claimed in any one of claims 1 to 7 comprises the following steps: S1. Grind all the medicinal materials and three auxiliary materials with a universal grinder; S2. Put the crushed fine powder into a three-dimensional motion mixer and mix for 30 to 40 minutes; S3, adding a binder to the mixed powder, and placing it into a high-efficiency wet granulator for granulation; S4, drying the prepared wet granules with a fluidized bed dryer to remove moisture; S5. The dried granules are sieved to remove adhesion and fine powder; S6, pressing the granules into tablets using a rotary tablet press; S7. Coat the compressed tablets using a high-efficiency coating machine.

9. The method for preparing the Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 8, characterized in that: The stirring speed of the high-efficiency wet granulator in step S3 is 300-400 r / min, and the granulation time is 15-30 min; the air inlet temperature of the fluidized bed dryer in step S4 is 60-100° C., the air outlet temperature is 40-50° C., and the drying time is 20-30 min; the pressure range of the rotary tablet press in step S6 is 10-80 kN; the coating time of the high-efficiency coating machine in step S7 is 30-40 min, and the temperature is 40-50° C.

10. The method for preparing the Chinese medicinal compound preparation for treating cardiovascular and cerebrovascular diseases according to claim 8, characterized in that: The crushing particle size in the step S1 is 80-200 meshes; the sieve mesh number in the step S5 is 10-40 meshes.

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